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  • Artikel  (10)
  • calcium  (9)
  • heart
  • Springer  (10)
  • National Academy of Sciences
  • 1995-1999
  • 1975-1979  (10)
  • 1979  (10)
  • Medizin  (10)
Sammlung
  • Artikel  (10)
Datenquelle
Schlagwörter
Verlag/Herausgeber
Erscheinungszeitraum
  • 1995-1999
  • 1975-1979  (10)
Jahr
Thema
  • 1
    Digitale Medien
    Digitale Medien
    Influence of milk products on fluoride bioavailability in man (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 211-215 
    Details
    ISSN: 1432-1041
    Schlagwort(e): fluoride ; bioavailability ; calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of milk products on the gastrointestinal absorption of fluoride from sodium fluoride tablets was studied in five healthy subjects. Two different diets were tested: (1) 250 ml standardized milk (3% fat) and (2) 500 ml of milk, 3 pieces of white bread with cheese and 150 ml of yoghurt. The 100% bioavailability of sodium fluoride tablets during fasting was greatly decreased by coadministration of milk products: with Diet 1 the absolute bioavailability calculated from combined plasma and urine data was in the range 50–79% and with Diet 2 it ranged from 50–71%. It is suggested that the decreased bioavailability produced by dairy products should be taken into account when establishing fluoride dosage regimens for prophylaxis of caries.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00562063
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Sarcoplasmic reticulum Ca2+-pump density is higher in distal than in proximal segments of porcine left coronary artery (1979)
    Springer
    Molecular and cellular biochemistry 158 (1979), S. 91-95 
    Details
    ISSN: 1573-4919
    Schlagwort(e): smooth muscle ; vascular ; ATPase ; calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract Densities of sarcoplasmic reticulum (SR) Ca2+-pump were compared in proximal and distal segments of pig left coronary artery using two biochemical methods: acylphosphate formation and immunoreactivity in Western blots, and a functional assay based on contraction to SR Ca2+-pump inhibitors. In the microsomes prepared from smooth muscle, the level of the 115 kDa SR Ca2+-pump acylphosphate was 7.1 ± 0.3 -fold greater in distal than in proximal segments. Similarly in Western blots using these microsomes, the reactivity of the 115 kDa band to an anti-SR Ca2+-pump antibody was 5.3 ± 0.8 -fold greater in distal than in proximal segments. Endothelium free coronary artery rings contracted to the SR Ca2+-pump inhibitors Cyclopiazonic acid (CPA, EC50 = 0.19 ± 0.06 μM) and thapsigargin (EC50 = 0.0095 ± 0.0035 μM). With 10 μM CPA, the force of contraction per tissue wet weight was 4.2 ± 0.5-fold greater in distal than in proximal rings, and with 1 μM thapsigargin it was 4.0 ± 1.0 -fold greater. The contractions produced by 60 mM KCl were used as a control. In contrast to the CPA and thapsigargin, the force per mg tissue weight produced by 60 mM KCl did not differ significantly between the proximal and distal segments. Thus, the results from the two biochemical methods and those from the contractility data were all consistent with the smooth muscle in the distal segments of the coronary artery containing a higher density of the SR Ca2+-pump than the proximal segments.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225887
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Characterization of calcium accumulation in the brain of rats administered orally calcium: The significance of energy-dependent mechanism (1979)
    Springer
    Molecular and cellular biochemistry 158 (1979), S. 1-7 
    Details
    ISSN: 1573-4919
    Schlagwort(e): calcium ; calcium transport ; brain ; calcium-regulating hormone ; calcium-antagonist ; energy dependency
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie , Medizin
    Notizen: Abstract The characterization of calcium accumulation in the brain of rats administered orally calcium chloride solution was investigated. Rats received a single oral administration of calcium (15–50 mg/100 g body weight), and they were sacrificed by bleeding-between 15 and 120 min after the administration. The administration of calcium (50 mg/100 g) produced a significant increase in serum calcium concentration and a corresponding elevation of brain calcium content, indicating that the transport of calcium into the brain is associated with the elevation of serum calcium levels. The increase in brain calcium content by calcium administration was not appreciably altered by the pretreatment with Ca2+ channel blockers (verapamil or diltiazem with the doses of 1.5 and 3.0 mg/100 g). In thyroparathyroidectomized rats, the administration of calcium (50 mg/100 g) caused a significant increase in brain calcium content, indicating that calcium-regulating hormones do not participate in the brain calcium transport. Now, brain calcium content was clearly elevated by fasting (overnight), although serum calcium level was not significantly altered. Calcium administration to fasted rats induced a further elevation of brain calcium content as compared with that of control (fasted) rats. The fasting-induced increase in brain calcium content was appreciably restored by refeeding. This restoration was also seen by the oral administration of glucose (0.4 g/100 g) to fasted rats. The present study demonstrates that serum calcium is transported to brain, and that the increased brain calcium is released promptly. The release of calcium from brain may be involved in energy metabolism, and this release may be weakened by the reduction of glucose supply into brain. The finding suggests a physiological significance of energy-dependent mechanism in the regulation of brain calcium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00225876
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Dependence of activity of cholinergic mechanisms of the heart on the state of its sympathetic innervation and noradrenalin content in hypoxia (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 542-544 
    Details
    ISSN: 1573-8221
    Schlagwort(e): hypoxia ; heart ; sympathetic and parasympathetic regulation ; interaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Removal of the inferior cervical and stellate ganglia abolishes the property of moderate hypoxia (7–8% O2 in N2) to increase the reserves of acetylcholine (ACh) and acetylcholine-like substances in the heart and leads to exhaustion of these reserves during deep hypoxia (3–4% O2 in N2). Under hypoxic conditions reduction of the noradrenaline (NA) reserves in the heart by reserpine weakens, whereas perfusion of the heart with Krebs-Henseleit solution containing NA, potentiates the action of ACh on the isolated heart. In hypoxia, exogenous NA raises the potassium level in the myocardium. It is suggested that NA stimulates cholinergic mechanisms and modified potassium metabolism in the myocardium. Exhaustion of the NA reserves in hypoxia leads to functional isolation of the heart not only from sympathetic, but also from parasympathetic influences.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00801379
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Increased sensitivity of adipose tissue of spontaneously hypertensive rats to ACTH (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 696-699 
    Details
    ISSN: 1573-8221
    Schlagwort(e): hypertension ; ACTH ; lipolysis ; calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The action of ACTH on lipolysis was studied in the adipose tissue of rats with spontaneous and renal hypertension and also in normotensive rats of corresponding control groups. The sensitivity of the adipose tissue of SHR rats to ACTH was shown to be higher than in the normotensive control. Evidence was obtained that this increase in sensitivity is due to the state or quantity of intracellular calcium. In rats with renal hypertension no such increase in sensitivity of their adipose tissue to ACTH was found.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00804767
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Tissue-specific uncouplers of oxidative phosphorylation of mitochondria from the rat heart, kidney, thymus, and lung (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 128-130 
    Details
    ISSN: 1573-8221
    Schlagwort(e): tissue-specific uncouplers ; calcium ; phospholipase A ; DNase I
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The effect of microsome-free cytoplasmic fractions from the rat heart, kidney, thymus, and lung on oxidative phosphorylation (OP) of mitochondria (MCH) from these tissues and also of MCH from liver and brain was investigated. Crossed experiments showed the existence of tissue-specific uncouplers of OP in these fractions, similar in their properties to that found oreviously in rat liver. The possible role of these regulators in the initiation of enzymic degradation of MCH through activation of phospholipase A during the outflow of calcium ions from MCH is discussed. Activation of DNase I associated with the mitochondrial membrane is postulated under these conditions.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00833967
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Effect of presynaptic neurotoxins from bee and cobra venom on spontaneous mediator secretion from mouse motor nerve ending (1979)
    Springer
    Bulletin of experimental biology and medicine 87 (1979), S. 402-405 
    Details
    ISSN: 1573-8221
    Schlagwort(e): presynaptic toxins ; mouse diaphragm ; spontaneous liberation of mediator ; phospholipases ; calcium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Phosphorylases A2 (PLA) from bee and cobra venoms cause triphasic changes in the frequency of miniature endplate potentials (MEPPs) recorded in the mouse diaphragm: an initial decrease of liberation of mediator followed by an increase, followed in turn by complete blocking of liberation. Removal of Ca++ from the perfusing solution (to concentrations below 10−9M) prevented the presynaptic effect of the two PLAs. If the PLA was washed off with calcium-free solution, subsequent treatment with standard solution (2 mM Ca++) caused an increase in the frequency of MEPPs. Agents increasing the Ca++ concentration in the axoplasm (K+ ions, hypertonic sucrose, and the uncoupling agent 4, 5, 6, 7-tetra-2-trifluoromethylbenzimidazole) caused an increase in the MEPP frequency in muscles poisoned with PLA. Blocking the liberation of mediator evidently was not caused by exhaustion of its reserves.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00806665
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    The role of calcium in the mechanism of changes in vascular reactivity due to reserpine (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 722-727 
    Details
    ISSN: 1573-8221
    Schlagwort(e): calcium ; reserpine ; reactivity of blood vessels
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract Under the influence of reserpine there is a marked decrease in the calcium concentration in segments of the distal aorta and femoral arteries of rabbits, incubated in salt solution. These changes develop parallel with changes in the character of responses of the vascular segments to direct electrical stimulation (weakening of the effects of contraction, followed by relaxation). A decrease in the calcium concentration in the vascular wall is suggested as one cause of the change in vascular reactivity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00804776
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  • 9
    Digitale Medien
    Digitale Medien
    Respiration-stimulated activation of deoxyribonuclease I associated with mitochondria (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 1275-1278 
    Details
    ISSN: 1573-8221
    Schlagwort(e): Mitochondria ; DNase I ; calcium ; respiration ; phospholipase A
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The effect of respiration and calcium transport in the liver mitochondria on activation of DNase I associated with the organelles was investigated. It was shown that 96% of the total activity of this enzyme in the mitochondria is in a latent state. Aeration of a suspension of mitochondria leads to a sharp rise in its activity. Activation of DNase I is inhibited by the addition of EGTA and stimulated in mitochondria releasing calcium. The pH optimum of EGTA-inhibited activation of DNase I was shown to be 8.0. It is concluded that activation of this enzyme depends on the state of cellular energetics. It is suggested that a role is played by mitochondrial phospholipase A, activated during release of calcium from the mitochondria in the process of activation of DNase I.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00835570
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  • 10
    Digitale Medien
    Digitale Medien
    Action of the presynaptic neurotoxin notechis II-5 from the venom of Notechis scutatus scutatus on mouse motor nerve endings (1979)
    Springer
    Bulletin of experimental biology and medicine 88 (1979), S. 1132-1134 
    Details
    ISSN: 1573-8221
    Schlagwort(e): Presynaptic neurotoxins ; mamalian motor nerve endings ; spontaneous liberation of mediator ; calcium ; phospholipases
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Abstract The neurotoxin notechis II-5 (N-II-5) from the venom of the Australian tiger snake (Viperidae family) gave rise to changes in the frequency of miniature end-plate potentials (MEPP) in the mouse diaphragm in three distinct phases: An initial decrease in frequency, then an increase, and finally a decrease in the frequency of MEPP or even a complete block. The effect of N-II-5 was enhanced with a rise in the temperature of the solution from 20 to 30 and 35°C. There was no effect if Ca++ was removed from the solution. Addition of Ca++ to the solution after washing the muscle to remove N-II-5 effect. In the presence of N-II-5, an increase in the K+ concentration in the solution to 20 mM did not lead to a sharp increase in the frequency of MEPP typical of depolarized nerve endings. Agents which increased the intracellular Ca++ concentration, not through depolarization of the nerve endings (hypertonic solution, ionophore A 23187), preserved the ability to increase the frequency of MEPP. It is suggested that the presynaptic effect of N-II-5 is connected with its phosphorylase activity and can be explained by the disturbance of the activity of the liberation sites and not by exhaustion of mediator reserves.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00838185
    Standort Signatur Erwartet Verfügbarkeit
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