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  • Inorganic Chemistry  (720)
  • Organic Chemistry  (689)
  • Humans  (276)
  • 550 - Earth sciences
  • SPACE SCIENCES
  • Statistical Physics
  • 2015-2019
  • 1975-1979  (1,699)
  • 1979  (1,699)
Collection
Keywords
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  • 2015-2019
  • 1975-1979  (1,699)
Year
  • 1
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    Sleeping pills and insomnia (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-06
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Anylan, W G -- Gillin, C -- Solomon, F -- New York, N.Y. -- Science. 1979 Jul 6;205(4401):6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/451580" target="_blank"〉PubMed〈/a〉
    Keywords: Flurazepam/adverse effects/therapeutic use ; Humans ; Hypnotics and Sedatives/adverse effects/*therapeutic use ; Sleep Initiation and Maintenance Disorders/*drug therapy
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Metabolism of theophylline to caffeine in human fetal liver (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: Caffeine (1,3,7-trimethylxanthine) is a biotransformation product of theophylline (1,3-dimethylxanthine) in the human fetus. Liver explants, obtained from human fetuses with gestational ages of 12 to 20 weeks, were incubated with theophylline and produced caffeine and, in lesser amounts, 1,3-dimethyluric acid and 3-methylxanthine. These findings suggest that the predominant pathway in theophylline metabolism in the fetus and newborn infant is the methylation reaction producing caffeine. This may contribute to the neonate's exceedingly slower elimination of caffeine relative to theophylline. Caffeine produced from theophylline may add to the pharmacologic effects of theophylline in newborn infants with apnea.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Aranda, J V -- Louridas, A T -- Vitullo, B B -- Thom, P -- Aldridge, A -- Haber, R -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1319-21.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515734" target="_blank"〉PubMed〈/a〉
    Keywords: Apnea/drug therapy ; Biotransformation ; Caffeine/*biosynthesis/metabolism/therapeutic use ; Cells, Cultured ; Gestational Age ; Humans ; Infant, Newborn ; Liver/*embryology/metabolism ; Methylation ; Theophylline/*metabolism/therapeutic use
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    Regional localization of the gene for human phosphoribosylpyrophosphate synthetase on the X chromosome (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-03-09
    Description: Sixty-eight independent hybrid clones were isolated after irradiated normal human lymphocytes were fused with Chinese hamster fibroblasts lacking hypoxanthine-guanine phosphoribosyltransferase activity. The cells were grown under selective conditions requiring retention of the X chromosome-linked locus for human hypoxanthine-guanine phosphoribosyltransferase. The frequency and patterns of cotransference of human phosphoribosylpyrophosphate synthetase with the selected marker and with additional X-linked enzymatic markers confirm X linkage of the structural gene for human phosphoribosylpyrophosphate synthetase and support assignment of this gene to a position on the long arm of the X, between the loci for alpha-galactosidase and hypoxanthine-guanine phosphoribosyltransferase.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Becker, M A -- Yen, R C -- Itkin, P -- Goss, S J -- Seegmiller, J E -- Bakay, B -- New York, N.Y. -- Science. 1979 Mar 9;203(4384):1016-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218284" target="_blank"〉PubMed〈/a〉
    Keywords: Chromosome Mapping ; Female ; Genetic Linkage ; Humans ; Hybrid Cells ; Hypoxanthine Phosphoribosyltransferase/genetics ; Phosphotransferases/*genetics ; Ribose-Phosphate Pyrophosphokinase/*genetics ; *Sex Chromosomes ; *X Chromosome
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Food additives (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-12-14
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Benarde, M A -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1256-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/515730" target="_blank"〉PubMed〈/a〉
    Keywords: *Carcinogens ; Food Additives/*adverse effects ; Humans ; Public Opinion
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Pituitary-brain vascular relations: a new paradigm (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-06
    Description: Vascular casts of the pituitary gland have demonstrated a paucity of veins extending from the adenohypophysis to the systemic circulation and have suggested that some adenohypophyseal venous blood returns to the neurohypophysis. The neurohypophyseal capillary bed may function as a vascular switch and in this article a series of 14 questions are proposed regarding the vascular dynamics of the pituitary. Together these questions raise the larger question, namely, whether pituitary hormones are transported directly to the brain to modify brain function?〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Bergland, R M -- Page, R B -- New York, N.Y. -- Science. 1979 Apr 6;204(4388):18-24.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/373118" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arteriovenous Anastomosis/anatomy & histology ; Capillaries/anatomy & histology ; Cats ; *Cerebrovascular Circulation ; Dogs ; Humans ; Hypothalamo-Hypophyseal System/blood supply ; Pituitary Gland/*blood supply ; Pituitary Gland, Anterior/blood supply ; Rats ; Species Specificity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    New strength in the diet-disease link? (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-11-09
    Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Broad, W J -- New York, N.Y. -- Science. 1979 Nov 9;206(4419):666-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/493971" target="_blank"〉PubMed〈/a〉
    Keywords: Diet/*adverse effects ; Disease/*etiology ; Humans ; Legislation as Topic ; National Institutes of Health (U.S.) ; Nutritional Physiological Phenomena ; Peer Review ; Preventive Medicine/methods ; Research Support as Topic ; United States
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Metabolism of americium-241 in man: an unusual case of internal contamination of a child and his father (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-10-05
    Description: The metabolism of americium-241 has been studied during an 8-year period in an adult male and his son who, at the ages of 50 and 4 years, respectively, were accidentally and unknowingly contaminated within their home by means of inhalation. Chelation therapy with calcium trisodium pentetate was more effective in enhancing the removal of americium-241 from the child than from the father.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, N -- Sasso, T L -- Wrenn, M E -- New York, N.Y. -- Science. 1979 Oct 5;206(4414):64-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/482925" target="_blank"〉PubMed〈/a〉
    Keywords: Age Factors ; Americium/*metabolism/poisoning ; Body Burden ; Body Height ; Body Weight ; Bone and Bones/metabolism ; Chelating Agents/*therapeutic use ; Child, Preschool ; Humans ; Liver/metabolism ; Lung/metabolism ; Male ; Middle Aged
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Comparative biochemistry and drug design for infectious disease (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-09-07
    Description: In the past two decades, biochemistry and molecular biology have demonstrated the existence of potentially exploitable biochemical differences between etiologic agents of disease and their hosts. Known differences between organism and host with respect to metabolism and polymer structure point to the detailed characterization of key proteins as the focus for the development of potential inhibitors. In the last decade, the methodology of the isolation, characterization, and inactivation of proteins and enzymes has been advanced. The present scientific and technological base suggests that new efforts toward the development of selective chemotherapeutic agents for infections caused by bacteria, viruses, protozoa, and higher eukaryotes should exploit the known differences in proteins or other specific biopolymers serving crucial structural or metabolic roles in the economy of the parasite.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cohen, S S -- New York, N.Y. -- Science. 1979 Sep 7;205(4410):964-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/382357" target="_blank"〉PubMed〈/a〉
    Keywords: *Anti-Bacterial Agents ; *Antiviral Agents ; Communicable Diseases/*drug therapy ; Humans ; Mycobacterium leprae/metabolism ; Polysaccharides, Bacterial/metabolism ; Species Specificity ; Structure-Activity Relationship ; Trypanosomiasis/drug therapy ; Vidarabine/pharmacology ; Viral Proteins/biosynthesis ; Virus Replication/drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Ingested mineral fibers: elimination in human urine (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-04-13
    Description: Sediment in human urine examined by transmission electron microscopy contains amphibole fibers which originate from the ingestion of drinking water contaminated with these mineral fibers. The ingestion of filtered water results in the eventual disappearance of amphibole fibers from urine. These observations provide the first direct evidence for the passage of mineral fibers through the human gastro-intestinal mucosa under normal conditions of the alimentary canal.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Cook, P M -- Olson, G F -- New York, N.Y. -- Science. 1979 Apr 13;204(4389):195-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/219478" target="_blank"〉PubMed〈/a〉
    Keywords: Adult ; Aged ; Female ; Gastric Mucosa/metabolism ; Humans ; Intestinal Absorption ; Intestinal Mucosa/metabolism ; Male ; Middle Aged ; Silicon Dioxide/metabolism/*urine ; *Water Pollutants ; *Water Pollutants, Chemical
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Preferential transmission of the Z deficient allele of alpha 1-antitrypsin (1979)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1979-07-27
    Description: The transmission of the Z deficient allele of alpha 1-antitrypsin was studied in 23 families, each with a single parent heterozygous for this allele. When the mother carried the Z allele, the distribution of phenotypes in the children did not differ significantly from the expected frequency. In contrast, when the father was the carrier, a significant increase of heterozygous phenotypes was observed in the children. This observation suggests that a selective advantage is associated with the expression of the Z allele in male gametes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chapuis-Cellier, C -- Arnaud, P -- New York, N.Y. -- Science. 1979 Jul 27;205(4404):407-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/313077" target="_blank"〉PubMed〈/a〉
    Keywords: *Alleles ; Child ; Female ; Heterozygote Detection ; Humans ; Male ; *Polymorphism, Genetic ; Sex Factors ; alpha 1-Antitrypsin/genetics ; *alpha 1-Antitrypsin Deficiency
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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