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  • Chemistry  (6,963)
  • Angiosperms
  • CR: 5.17
  • Coleoptera
  • pharmacokinetics
  • 2020-2024
  • 2010-2014
  • 2005-2009
  • 1980-1984  (7,089)
  • 1945-1949
  • 1935-1939
  • 1982  (7,089)
  • 1979
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  • 2020-2024
  • 2010-2014
  • 2005-2009
  • 1980-1984  (7,089)
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  • 1
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    Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-09-10
    Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉
    Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-07-09
    Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 3
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    New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-10
    Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉
    Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 4
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    The chemistry of vision (1982)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1982-12-03
    Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 5
    Electronic Resource
    Electronic Resource
    Behandlung steifer Anfangswertprobleme gewöhnlicher Differentialgleichungen mit adaptiven Runge-Kutta-Methoden (1982)
    Springer
    Computing 29 (1982), S. 153-165 
    Details
    ISSN: 1436-5057
    Keywords: 65L05 ; CR: 5.17 ; Numer. Analysis ; verallgemeinerte Runge-Kutta-Methoden ; steife Probleme
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract Adaptive Runge-Kutta-methods are considered. Investigations of stability for these linear implicit methods are studied. For the application a LS-stable method of order four with an adaptive stepsize control is proposed. Test results for 25 stiff initial value problems for different tolerances are discussed.
    Notes: Zusammenfassung Es werden adaptive Runge-Kutta-Verfahren betrachtet und Stabilitätsuntersuchungen für diese linear impliziten Methoden durchgeführt. Für die Anwendung wird ein LS-stabiles Verfahren vierter Ordnung mit einer angepaßten Schrittweitenkontrolle vorgeschlagen. Testergebnisse von 25 stiff Anfangswertproblemen für verschiedenen Toleranzen werden diskutiert.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02249938
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  • 6
    Electronic Resource
    Electronic Resource
    Approximation of time-dependent free boundaries (1982)
    Springer
    Numerische Mathematik 40 (1982), S. 179-199 
    Details
    ISSN: 0945-3245
    Keywords: AMS(MOS) ; Primary 65N30 ; Secondary 35R35 ; CR: 5.17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary Two problems are considered in the paper: the first of them is connected with elliptic variational inequalities and consists in developing a moving obstacle algorithm for approximating the unknown free boundary; the other problem is linked with numerical solution of the Stefan problem, which is formulated in the similar way as in the elliptic case. Some computational aspects are also discussed in the paper.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400538
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  • 7
    Electronic Resource
    Electronic Resource
    Finite elements for parabolic equations backwards in time (1982)
    Springer
    Numerische Mathematik 40 (1982), S. 207-227 
    Details
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65M30 ; CR: 5.17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary Several regularization methods for parabolic equations backwards in time together with the usual additional constraints for their solution are considered. The error of the regularization is estimated from above and below. For a “boundary value problem in time”-method, finite elements as well as a time discretization are introduced and the error with respect to the regularized solution is estimated, thus giving an overall error of the discrete regularized problem. The algorithm is tested in simple numerical examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01400540
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  • 8
    Electronic Resource
    Electronic Resource
    Adams methods for neutral functional differential equations (1982)
    Springer
    Numerische Mathematik 39 (1982), S. 221-230 
    Details
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65L05 ; CR: 5.17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary In this paper Adams type methods for the special case of neutral functional differential equations are examined. It is shown thatk-step methods maintain orderk+1 for sufficiently small step size in a sufficiently smooth situation. However, when these methods are applied to an equation with a “non-smooth” solution the order of convergence is only one. Some computational considerations are given and numerical experiments are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01408695
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  • 9
    Electronic Resource
    Electronic Resource
    Improvement of numerical solution of boundary layer problems by incorporation of asymptotic approximations (1982)
    Springer
    Numerische Mathematik 39 (1982), S. 309-324 
    Details
    ISSN: 0945-3245
    Keywords: AMS (MOS): 65L10 ; CR: 5.17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary A method for improvement of the numerical solution of differential equations by incorporation of asymptotic approximations is investigated for a class of singular perturbation problems. Uniform error estimates are derived for this method when implemented in known difference schemes and applied to linear second order O.D.E.'s. An improvement by a factor ofε n+1 can be obtained (where ɛ is the “small” parameter andn is the order of the asymptotic approximation) for a small amount of extra work. Numerical experiments are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407865
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  • 10
    Electronic Resource
    Electronic Resource
    Finite difference methods and their convergence for a class of singular two point boundary value problems (1982)
    Springer
    Numerische Mathematik 39 (1982), S. 341-350 
    Details
    ISSN: 0945-3245
    Keywords: AMS(MOS): 65L10 ; CR: 5.17
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mathematics
    Notes: Summary We discuss the construction of three-point finite difference approximations and their convergence for the class of singular two-point boundary value problems: (x α y′)′=f(x,y), y(0)=A, y(1)=B, 0〈α〈1. We first establish a certain identity, based on general (non-uniform) mesh, from which various methods can be derived. To obtain a method having order two for all α∈(0,1), we investigate three possibilities. By employing an appropriate non-uniform mesh over [0,1], we obtain a methodM 1 based on just one evaluation off. For uniform mesh we obtain two methodsM 2 andM 3 each based on three evaluations off. For α=0,M 1 andM 2 both reduce to the classical second-order method based on one evaluation off. These three methods are investigated, theirO(h 2)-convergence established and illustrated by numerical examples.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01407867
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