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1

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Benzo(a)pyrene-7,8-dihydrodiol 9,10-oxide adenosine and deoxyadenosine adducts: structure and stereochemistry (1979)

A. M. Jeffrey ; K. Grzeskowiak ; I. B. Weinstein ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 206(4424): 1309-11.

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Publication Date: 1979-12-14

Description: The structure and absolute stereoconfigurations of four adenosine adducts with (+/-)-7 alpha,8 beta-dihydroxy-9 beta, 10 beta-epoxy-7,8,9,10-tetrahydrobenzo(a)pyrene (BPDE) and their deoxyadenosine analogs have been determined. They result from both cis and trans addition of the N6 amino group of ademine to the 10 position of both enantiomers of BDPE. This was determined from studies of the nuclear magnetic resonance spectra, mass spectra, and circular dichroism spectra, as well as from their pKa values and chemical reactivities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jeffrey, A M -- Grzeskowiak, K -- Weinstein, I B -- Nakanishi, K -- Roller, P -- Harvey, R G -- New York, N.Y. -- Science. 1979 Dec 14;206(4424):1309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/316186" target="_blank"〉PubMed〈/a〉

Keywords: *Benzopyrenes ; Chemical Phenomena ; Chemistry ; Circular Dichroism ; Dna ; *Deoxyadenosines/analogs & derivatives ; Magnetic Resonance Spectroscopy ; Mass Spectrometry ; Molecular Conformation ; Mutation ; Stereoisomerism

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

Published by American Association for the Advancement of Science (AAAS)

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Alpha-substituted gamma-butyrolactones: new class of anticonvulsant drugs (1982)

W. E. Klunk ; A. McKeon ; D. F. Covey ; [et al.]

American Association for the Advancement of Science (AAAS)

In: Science. 217(4564): 1040-2.

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Publication Date: 1982-09-10

Description: Alkyl-Substituted gamma-butyrolactones were synthesized and tested for their convulsant and anticonvulsant actions in mice and guinea pigs. The alpha-substituted compounds, alpha, alpha-dimethyl-, and alpha-ethyl-alpha-methyl-gamma-butyrolactone were anticonvulsant compounds with a spectrum of activity similar to that of ethosuximide. In contrast, beta-substituted compounds were convulsant agents similar to picrotoxinin. The alpha-substituted-gama-butyrolactones represent a new class of anticonvulsant drug with experimental and clinical potential.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klunk, W E -- McKeon, A -- Covey, D F -- Ferrendelli, J A -- GM-07200/GM/NIGMS NIH HHS/ -- GM-24483/GM/NIGMS NIH HHS/ -- NS-14834/NS/NINDS NIH HHS/ -- etc. -- New York, N.Y. -- Science. 1982 Sep 10;217(4564):1040-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6810462" target="_blank"〉PubMed〈/a〉

Keywords: *4-Butyrolactone/analogs & derivatives/*therapeutic use/toxicity ; Animals ; *Anticonvulsants ; Chemical Phenomena ; Chemistry ; Convulsants ; Drug Evaluation, Preclinical ; Electroencephalography ; Epilepsy, Absence/drug therapy ; Ethosuximide/pharmacology ; *Furans/*therapeutic use ; Guinea Pigs ; Mice ; Structure-Activity Relationship ; Trimethadione/pharmacology

Print ISSN: 0036-8075

Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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Boradeption: a new procedure for transferring water-insoluble agents across cell membranes (1982)

P. M. Gallop ; M. A. Paz ; E. Henson

American Association for the Advancement of Science (AAAS)

In: Science. 217(4555): 166-9.

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Publication Date: 1982-07-09

Description: A new process has been developed which is called "Boradeption" to signify boronic acid--dependent phase transfer of water-insoluble agents. Highly fluorescent boronic acid dervatives, FluoroBoras, are solubilized with a physiologically compatible carrier buffer containing a receptor group for boronate adduct formation. The system can be used to stain living cells. In another variation of the Boradeption concept, an insoluble reporter molecule containing a boronate receptor is solubilized with a carrier buffer containing a boronic acid functional group. The boronate-receptor complexes, which are in dynamic equilibrium, can be designed as vital stains and reagents for a variety of biological and medical applications.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Gallop, P M -- Paz, M A -- Henson, E -- AG-00376-07/AG/NIA NIH HHS/ -- HL-20764-04A1/HL/NHLBI NIH HHS/ -- New York, N.Y. -- Science. 1982 Jul 9;217(4555):166-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6178158" target="_blank"〉PubMed〈/a〉

Keywords: Animals ; *Biological Transport ; *Boron Compounds/therapeutic use ; *Boronic Acids/therapeutic use ; *Cell Membrane Permeability ; Cells, Cultured ; Chemical Phenomena ; Chemistry ; Chromogenic Compounds/metabolism ; Cricetinae ; Fibroblasts ; Fluorescent Dyes/metabolism ; Humans ; Rats ; Staining and Labeling

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Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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4

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New chemistry of an old molecule: cis-[Pt(NH3)2Cl2] (1982)

S. J. Lippard

American Association for the Advancement of Science (AAAS)

In: Science. 218(4577): 1075-82.

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Publication Date: 1982-12-10

Description: The discovery that cis-diamminedichloroplatinum(II) (cis-DDP) has clinically useful antitumor properties and can form platinum blues spawned an extensive investigation of its chemistry in water. Several new molecules have been synthesized, some rather old ones have been characterized for the first time, and clues have begun to emerge about the chemical interaction of cis-DDP with its likely biological target, DNA.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Lippard, S J -- New York, N.Y. -- Science. 1982 Dec 10;218(4577):1075-82.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6890712" target="_blank"〉PubMed〈/a〉

Keywords: Chemical Phenomena ; Chemistry ; *Cisplatin ; *Dna ; Hydrolysis ; Pigments, Biological

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Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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5

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The chemistry of vision (1982)

D. F. O'Brien

American Association for the Advancement of Science (AAAS)

In: Science. 218(4576): 961-6.

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Publication Date: 1982-12-03

Description: The visual response is initiated by light reception and transduction into chemical and electrical energy in the outer-segment membranes of rod and cone cells. Recent research on the molecular events controlled by light has clarified the roles of some of the rod outer-segment biomolecules. These developments and the current unresolved questions are described.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉O'Brien, D F -- New York, N.Y. -- Science. 1982 Dec 3;218(4576):961-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291153" target="_blank"〉PubMed〈/a〉

Keywords: Animals ; Blood Proteins/metabolism ; Calcium/metabolism ; Chemical Phenomena ; Chemistry ; Enzyme Activation ; Enzymes/metabolism ; GTP-Binding Proteins ; Light ; Membranes/metabolism ; Models, Biological ; Phosphoric Diester Hydrolases/biosynthesis ; Photoreceptor Cells/*metabolism ; Receptors, Cell Surface/metabolism ; Rhodopsin/metabolism ; Rod Cell Outer Segment/*metabolism ; Vision, Ocular/*physiology

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Electronic ISSN: 1095-9203

Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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6

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N-formyliminodiacetic acid, a new compound from the reaction of nitrilotriacetic acid and chlorine (1979)

R. J. Spanggord ; C. A. Tyson

American Association for the Advancement of Science (AAAS)

In: Science. 204(4397): 1081-2.

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Publication Date: 1979-06-08

Description: It has been proposed that nitrilotriacetic acid be substituted for trisodium polyphosphates in detergents as a way to reduce the rate of eutrophication in the Great Lake Basin. The reaction of nitrilotriacetic acid with chlorine-containing solutions produces a hitherto unknown degradation production, N-formyliminodiacetic acid, in high yield. The toxicological and environmental implications of this reaction are unclear.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Spanggord, R J -- Tyson, C A -- New York, N.Y. -- Science. 1979 Jun 8;204(4397):1081-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/36659" target="_blank"〉PubMed〈/a〉

Keywords: *Acetates ; Chemical Phenomena ; Chemistry ; *Chlorine ; Dicarboxylic Acids ; Environmental Pollutants ; Hydrogen-Ion Concentration ; *Imino Acids ; Mutagens ; *Nitrilotriacetic Acid

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Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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HCN did not condense to give heteropolypeptides on the primitive earth (1979)

J. P. Ferris

American Association for the Advancement of Science (AAAS)

In: Science. 203(4385): 1135-7.

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Publication Date: 1979-03-16

Description: 〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ferris, J P -- New York, N.Y. -- Science. 1979 Mar 16;203(4385):1135-7.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/218287" target="_blank"〉PubMed〈/a〉

Keywords: Chemical Phenomena ; Chemistry ; *Hydrogen Cyanide ; *Peptides

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Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics

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Precise determination of the distances of galaxies (1979)

Tammann, G. A.

In: CASI

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Publication Date: 2006-01-16

Description: The use of the Space Telescope in the determination of the distances of galaxies is examined. The Space Telescope can check the local extragalactic distance scale to within 10-15 percent. The determination of relative distances of cosmic standard candles, viz. brightest M-supergiants and SNe I in E galaxies, is discussed. The M-supergiants map the velocity field out to v sub o approx. 3000 km s(-1) thus providing a firm basis for the determination of H sub o (global) from local distances, and the possibility to derive precise distances of all nearby field galaxies from their recession velocities. Photometry of the SNe I out to z = 0.5 leads to a direct determination of q sub o via the Hubble diagram, and the form of their light curves offers a fundamental test on the nature of redshifts. Other calculations are discussed.

Keywords: ASTROPHYSICS

Type: NASA. Marshall Space Flight Center Sci. Res. with the Space Telescope; p 263-293

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Requirements for predictions and real-time monitoring for the study of travelling interplanetary phenomena (1979)

Dryer, M. ; Shea, M. A.

In: CASI

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Publication Date: 2006-01-16

Description: Physical processes within quiescent as well as disturbed flows of solar wind plasma, energetic particles, and magnetic and electric fields from the Sun are considered. Specifically, travelling interplanetary phenomena to be studied during the years of the solar maximum of solar cycle 21 are covered. It is noted that predictions, while needed for long range, logistical planning, is secondary to the requirements of synoptic real time monitoring over a wide range of particle energies and spectral bandwidths.

Keywords: ASTROPHYSICS

Type: NASA. Marshall Space Flight Center Solar-Terrest. Predictions Proc., Vol. 2; p 340-345

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Kinetic theory in astrophysics and cosmology (1982)

Ray, J. R.

In: CASI

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Publication Date: 2006-02-14

Description: Results associated with exact solution of the Einstein-Boltzmann and Einstein-Maxwell-Boltzmann equations are presented. The generalization of Ehler's killing vector approach for the distribution function to charged particles is considered.

Keywords: ASTROPHYSICS

Type: Alabama Univ. in Huntsville The 1981 NASA(ASEE Summer Fac. Fellowship Program; 21 p

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