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  • Cell Line  (23)
  • American Association for the Advancement of Science (AAAS)  (23)
  • American Meteorological Society
  • Blackwell Publishing Ltd
  • Elsevier
  • Springer Nature
  • 1980-1984
  • 1975-1979  (23)
  • 1978  (23)
Collection
Keywords
Publisher
  • American Association for the Advancement of Science (AAAS)  (23)
  • American Meteorological Society
  • Blackwell Publishing Ltd
  • Elsevier
  • Springer Nature
Years
  • 1980-1984
  • 1975-1979  (23)
Year
  • 11
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    Magnetic microspheres prepared by redox polymerization used in a cell separation based on gangliosides (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-02
    Description: A facile method is described for making magnetic microspheres that bind specifically to cell surfaces, in order to separate cells magnetophoretically. Control over the sizes of the spheres is effected by using their magnetic cores as part of a redox polymerization system. The use of the microspheres is demonstrated with a separation involving C-1300 neuroblastoma cells, 10% of which express the ganglioside GM1 in their membranes. The GM1-containing cells were separated with better than 99% purity, while the deficient cells were obtained at least 98% pure. The separation, which was carried out under sterile conditions, required only 6 minutes.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Kronick, P L -- Campbell, G L -- Joseph, K -- New York, N.Y. -- Science. 1978 Jun 2;200(4345):1074-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/653356" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cell Separation/*methods ; *Gangliosides ; Magnetics ; Microspheres ; Neoplasms, Experimental/pathology ; Neuroblastoma/pathology ; Oxidation-Reduction
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 12
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    Histamine H1 receptor-mediated guanosine 3',5'-monophosphate formation by cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-07
    Description: Incubation of cultured mouse neuroblastoma cells with histamine caused a rapid and marked increase in the formation of guanosine 3',5'-monophosphate (cyclic GMP) by these cells. Receptor agonists for H1, but not H2, caused this effect which was reduced by H1 but not by H2 or muscarinic acetylcholine receptor antagonists. These results indicate that activation of H1 receptors in these cultured nerve cells stimulated cyclic GMP formation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Richelson, E -- New York, N.Y. -- Science. 1978 Jul 7;201(4350):69-71.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/26974" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Calcium/pharmacology ; Carbachol/pharmacology ; Cell Line ; Cyclic GMP/*metabolism ; Histamine/*pharmacology ; Histamine H1 Antagonists/pharmacology ; Mice ; Neuroblastoma ; Neurons/*drug effects/metabolism ; Receptors, Histamine/*drug effects ; Receptors, Histamine H1/*drug effects
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 13
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    Myosin: immunofluorescent localization in neuronal and glial cultures (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-31
    Description: The distribution of intracellular myosin was studied by the double antibody immunofluorescence method in primary organotypic neuronal cultures and two established neuronal and glial cell lines. An array of parallel filaments aligned with the major cellular axis and a three-dimensional subsurface network were shown to react with two different myosin antibodies. The presence of myosin-rich filaments in regions known to contain actin filaments suggests that these proteins interact to generate the motive force in nonmuscle contractile systems.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Roisen, F -- Inczedy-Marcsek, M -- Hsu, L -- Yorke, W -- New York, N.Y. -- Science. 1978 Mar 31;199(4336):1445-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/343252" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Line ; Cytoplasm/ultrastructure ; Fluorescent Antibody Technique ; Ganglia, Spinal/cytology ; Myosins/*metabolism ; Neuroglia/*metabolism/ultrastructure ; Neurons/*metabolism/ultrastructure
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 14
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    Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: A 172-base pair segment of DNA that is repeated several million times in the genome of the African green monkey has been characterized. Sequence analysis revealed that the many repeats of this complex unit are not all identical but represent a set of closely related segments: Sequence divergence occurs at various positions in the segment in a nonrandom manner. The uncloned segment obtained from monkey DNA is compared with a cloned segment of the same DNA which was recombined into the genome of simian virus 40 during permissive infection.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Rosenberg, H -- Singer, M -- Rosenberg, M -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):394-402.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/205944" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Base Sequence ; Biological Evolution ; Cell Line ; Cercopithecus/*genetics ; Cercopithecus aethiops/*genetics ; DNA/*genetics ; DNA Restriction Enzymes ; DNA, Recombinant ; Haplorhini ; Molecular Weight ; Recombination, Genetic ; Simian virus 40/genetics
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 15
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    Human breast cancer: androgen action mediated by estrogen receptor (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: Growth of the human breast cancer cell line MCF-7 is enhanced by androgens, but only at pharmacological concentrations. Although physiological concentrations of androgens translocate the androgen receptor into the nucleus, no mitogenic effects are observed. By contrast, pharmacological androgens translocate not only the androgen receptor but also the estrogen receptor, and at these high doses significantly increase both DNA and estrogen-dependent protein synthesis. We therefore propose that androgens stimulate MCF-7 cell growth not through the androgen receptor but rather through the estrogen receptor.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Zava, D T -- McGuire, W L -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):787-8.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622569" target="_blank"〉PubMed〈/a〉
    Keywords: Androgens/*pharmacology ; Breast Neoplasms/*metabolism ; Cell Line ; Cell Nucleus/drug effects/metabolism ; Cytoplasm/drug effects/metabolism ; Dihydrotestosterone/pharmacology ; Humans ; Receptors, Androgen/drug effects ; Receptors, Estrogen/drug effects/*physiology ; Receptors, Glucocorticoid/drug effects/metabolism ; Receptors, Progesterone/drug effects/metabolism ; Stimulation, Chemical ; Translocation, Genetic
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 16
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    Tumor promoters inhibit morphological differentiation in cultured mouse neuroblastoma cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-05-05
    Description: When added to mouse neuroblastoma cultures, the potent tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) inhibits spontaneous neurite formation as well as that induced in response to serum deprivation, prostaglandin E1, 5-bromo-2'-deoxyuridine, and papaverine. Other tumor-promoting macrocyclic plant diterpenes also inhibit neurite formation, whereas nonpromoting diterpenes do not. Inhibition by TPA was reversible and was unrelated to toxicity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Ishii, D N -- Fibach, E -- Yamasaki, H -- Weinstein, I B -- New York, N.Y. -- Science. 1978 May 5;200(4341):556-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644318" target="_blank"〉PubMed〈/a〉
    Keywords: Bromodeoxyuridine/antagonists & inhibitors ; Cell Differentiation/drug effects ; Cell Line ; Diterpenes/pharmacology ; Dose-Response Relationship, Drug ; Neuroblastoma/pathology ; Neurons/*cytology ; Papaverine/antagonists & inhibitors ; Phorbols/*pharmacology ; Prostaglandins E/antagonists & inhibitors ; Tetradecanoylphorbol Acetate/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 17
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    Chick embryonic skin as a rapid organ culture assay for cellular neoplasia (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: We used chick embryonic skin (CES) in organ culture to assess the neoplastic potential of a variety of cultured human and nonhuman cell lines. Cells derived from cancer tissues grew in CES and formed tumors in nude mice while cells derived from normal tissues grew in neither system. The CES proved to be more sensitive than the nude mouse when used to assay SV40 transformed human cells; each of four such lines grew in CES while only one of the four lines grew and formed tumors in nude mice. In addition, the patterns of invasion by inoculated cells can be easily studied in the CES. These results suggest that CES in organ culture offers an inexpensive, rapid, and reliable alternative to the nude mouse as a tumorigenicity test.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Noguchi, P D -- Johnson, J B -- O'Donnell, R -- Petricciani, J C -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):980-3.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203036" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Division ; Cell Line ; Cell Survival ; *Cell Transformation, Neoplastic ; *Chick Embryo/metabolism ; Mice ; Mice, Nude ; Mitosis ; Neoplasm Invasiveness ; Neoplasms/*metabolism/pathology ; *Organ Culture Techniques ; Simian virus 40 ; Skin/*embryology/metabolism/pathology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 18
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    Histidine transfer RNA levels in Friend leukemia cells: stimulation by histidine deprivation (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-08-11
    Description: Friend leukemia cells incubated with sublethal concentrations of histidinol for 5 to 6 days show up to twofold increases in their relative concentrations of histidine transfer RNA and no change in the relative concentrations of leucine transfer RNA. A similar effect is seen when cells are grown to stationary phase in the presence of 0.2 times the amount of histidine in Eagle's minimum essential medium. These observations support the theory that the concentrations of specific transfer RNA's are regulated by a mechanism that is sensitive to the extent of their aminoacylation.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Litt, M -- Weiser, K -- New York, N.Y. -- Science. 1978 Aug 11;201(4355):527-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/248241" target="_blank"〉PubMed〈/a〉
    Keywords: Cell Division ; Cell Line ; Histidine/metabolism ; Histidine-tRNA Ligase/antagonists & inhibitors ; Histidinol/pharmacology ; Leucine/metabolism ; RNA, Transfer/*metabolism ; RNA, Transfer, Amino Acyl/*metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 19
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    Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: Exogenously added prostaglandins E1 and E2, but not F2alpha, inhibited the tumoricidal activity of interferon-activated macrophages of mice. A role for adenosine 3',5'-monophosphate (cyclic AMP) in modulating macrophage functional activity was suggested because prostaglandins of the E series increase intracellular concentrations of cyclic AMP in macrophages and because treatment of interferon-activated macrophages with dibutyryl cyclic AMP consistently inhibits expression of cytotoxicity. Since the activated macrophage releases high concentrations of prostaglandin E2, it is postulated that this prostaglandin could act locally in negative feedback inhibition to limit cell activities.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Schultz, R M -- Pavlidis, N A -- Stylos, W A -- Chirigos, M A -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):320-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/694537" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Cell Line ; Cytotoxicity, Immunologic/drug effects ; Immunity, Cellular/*drug effects ; Interferons/*antagonists & inhibitors ; Macrophages/*immunology ; Male ; Mice ; Neoplasms, Experimental/*immunology ; Nucleotides, Cyclic/pharmacology ; Prostaglandins E/*pharmacology ; Prostaglandins F/pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
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  • 20
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    L-Dopa methyl ester: prolongation of survival of neuroblastoma-bearing mice after treatment (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-02-17
    Description: L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. Since melanocytes arise from the neural crest embryologically, the effect of L-dopa methyl ester, a soluble analog, on the murine C1300 neuroblastoma was studied. There was significant antitumor activity against the neuroblastoma, which was enhanced by combination with a dopa decarboxylase inhibitor, Ro4-4602. In vitro studies suggested inhibition of DNA synthesis as the principal site of action. A mechanism involving sulfhydryl compound scavenging is postulated.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Wick, M M -- New York, N.Y. -- Science. 1978 Feb 17;199(4330):775-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/622565" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Benserazide/pharmacology ; Cell Line ; Drug Synergism ; Leucine/metabolism ; Levodopa/*analogs & derivatives/pharmacology/therapeutic use ; Male ; Mice ; Neoplasms, Experimental/drug therapy/metabolism ; Neuroblastoma/*drug therapy/metabolism ; Thymidine/metabolism ; Uridine/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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