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  • Articles  (33)
  • In Vitro Techniques  (33)
  • 1975-1979  (33)
  • 1978  (33)
  • 1977
  • Computer Science  (33)
  • Geosciences
  • Technology
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  • Articles  (33)
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  • 1975-1979  (33)
Year
  • 1978  (33)
  • 1977
  • 1979  (14)
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  • 1
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    Excitation-contraction coupling in skeletal muscle: blockade by high extracellular concentrations of calcium buffers (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-16
    Description: High concentrations (80 to 90 millimolar) of the calcium buffers EGTA and citrate (less than 10(-7) molar free calcium ion) reversibly block excitation-contraction coupling in intact frog skeletal fibers, but do not block caffeine-induced contractures. Solutions containing the same free calcium concentration but lower concentrations of calcium buffer (1 millimolar) do not block excitation-contraction coupling. These results suggest that excitation-contraction coupling requires the presence of calcium in a "protected" extracellular compartment, probably the transverse tubular network, and that calcium is actively transported into this compartment from the muscle cell cytoplasm.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Barrett, N -- Barrett, E F -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1270-2.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/96524" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials/drug effects ; Animals ; Anura ; Biological Transport, Active ; Calcium/*physiology ; Citrates/pharmacology ; Egtazic Acid/pharmacology ; Extracellular Space/metabolism ; In Vitro Techniques ; *Muscle Contraction/drug effects ; Muscles/*physiology ; Rana pipiens ; Sarcoplasmic Reticulum/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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  • 2
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    Fallopian tube isthmic mucus and ovum transport (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: The oviduct isthmus is capable of transporting spermatozoa and ova in opposite directions. A column of tenacious mucus that occupies the lumen of the rabbit oviduct isthmus during estrus may permit sperm transport. After ovulation the mucus disappears, with subsequent efforescence of cilia, which probably assist transport of ova to the uterus.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Jansen, R P -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):349-51.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/580814" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chorionic Gonadotropin/pharmacology ; Cilia/physiology ; Estradiol/pharmacology ; Fallopian Tubes/*physiology ; Female ; In Vitro Techniques ; Male ; Microscopy, Electron, Scanning ; Mucous Membrane/physiology ; Mucus/physiology ; Ovulation/drug effects ; *Ovum Transport ; Rabbits ; *Sperm Transport
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 3
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    Pineal serotonin N-acetyltransferase activity: abrupt decrease in adenosine 3',5'-monophosphate may be signal for "turnoff" (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-01-20
    Description: Dispersed pinealocytes have been used to study the role of adenosine 3',5'-monophosphate (cyclic AMP) in the "turnoff" of N-acetyltransferace activity. Activity was first stimulated 100-fold by treating cells with 1-norepinephrine. 1-Propranolol acted stereospecifically to rapidly reverse this, resulting in a 70 percent loss of enzyme activity within 15 minutes. An even more rapid 1-propranolol-induced decreased in cyclic AMP also occurred. This together with the observation that the inhibitory effect of 1-propranolol on N-acetyltransferase was blocked by dibutyryl cyclic AMP and phosphodiesterase inhibitors indicate that an abrupt decrease in cyclic AMP may be the signal for the rapid decrease in pineal N-acetyltransferase activity.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Klein, D C -- Buda, M J -- Kapoor, C L -- Krishna, G -- New York, N.Y. -- Science. 1978 Jan 20;199(4326):309-11.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/202027" target="_blank"〉PubMed〈/a〉
    Keywords: Acetyltransferases/antagonists & inhibitors/*metabolism ; Animals ; Bucladesine/pharmacology ; Cyclic AMP/*metabolism ; In Vitro Techniques ; Phosphodiesterase Inhibitors/pharmacology ; Pineal Gland/*metabolism ; Propranolol/antagonists & inhibitors/pharmacology ; Rats ; Serotonin
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 4
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    Cyclic adenosine monophosphate production by embryonic chick cells (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-03-03
    Description: Cells dissociated from 1-day-old chick embryos produce a pulse of cyclic adenosine monophosphate (cyclic AMP) when stimulated with cyclic AMP. There is a stimulus threshold concentration of about 10(-8) molar cyclic AMP and an upper limit, above which the response is suppressed, of about 6 X 10(-6) molar. The response occurs within 5 seconds of stimulation and corresponds to an average pulse size in the range of 10(7) molecules per cell.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Robertson, A -- Grutsch, J F -- Gingle, A R -- New York, N.Y. -- Science. 1978 Mar 3;199(4332):990-1.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/203037" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Chick Embryo/cytology/*metabolism ; Cyclic AMP/*biosynthesis/pharmacology ; In Vitro Techniques ; Radioisotope Dilution Technique
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 5
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    Is pump stimulation associated with positive inotropy of the heart? (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-06-16
    Description: A purified sodium and potassium dependent adenosinetriphosphatase isolated from cat heart was not stimulated by any concentration of ouabain that produced positive inotropy of cat papilliary muscle. Only inhibition of enzyme activity was observed. Concentrations of ouabain used ranged from 3.3 x 10(-10) molar to 5 x 10(-7) molar and produced an increased force of contraction without any evidence of toxicity. The results are inconsistent with a concept that stimulation of sodium pump activity is associated with positive inotropy.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Michael, L -- Pitts, B J -- Schwartz, A -- New York, N.Y. -- Science. 1978 Jun 16;200(4347):1287-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/149369" target="_blank"〉PubMed〈/a〉
    Keywords: Adenosine Triphosphatases/*antagonists & inhibitors ; Animals ; Biological Transport, Active/drug effects ; Cats ; Dose-Response Relationship, Drug ; In Vitro Techniques ; Myocardial Contraction/*drug effects ; Myocardium/*enzymology ; Ouabain/*pharmacology ; Potassium/metabolism ; Sodium/metabolism
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 6
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    Bursting neural networks: a reexamination (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-04-28
    Description: Many of the motor neurons in the lobster (Panulirus interruptus) stomatogastric ganglion exhibit plateau potentials; that is, prolonged regenerative depolarizations resulting from active membrane properties, that drive the neurons to fire impulses during bursts. Plateaus are latent in isolated ganglia but are unmasked by central input. These findings emphasize the role of cellular properties as compared to synaptic wiring in the production of cyclic motor patterns by ensembles of neurons.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Russell, D F -- Hartline, D K -- New York, N.Y. -- Science. 1978 Apr 28;200(4340):453-6.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/644309" target="_blank"〉PubMed〈/a〉
    Keywords: Action Potentials ; Animals ; Cell Membrane/physiology ; In Vitro Techniques ; Membrane Potentials ; Motor Neurons/physiology ; Nephropidae ; Nerve Net/*physiology ; *Nervous System Physiological Phenomena ; Periodicity
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 7
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    Secretion in mast cells induced by calcium entrapped within phospholipid vesicles (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-09-22
    Description: Purified mast cells secreted histamine when fused to phospholipid vesicles containing calcium but not magnesium or potassium. Microscopic observation revealed highly localized exocytotic responses involving punctate extrusion of individual granules. Calcium delivered from the vesicles to the cytoplasm is apparently a sufficient stimulus to initiate exocytosis. The results support the calcium hypothesis of stimulus-secretion coupling.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Theoharides, T C -- Douglas, W W -- New York, N.Y. -- Science. 1978 Sep 22;201(4361):1143-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/684435" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Ascitic Fluid/cytology ; Calcium/*pharmacology ; Exocytosis ; In Vitro Techniques ; Liposomes/*pharmacology ; Mast Cells/cytology/drug effects/*secretion ; Rats ; Ruthenium Red
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 8
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    Brain edema: induction in cortical slices by polyunsaturated fatty acids (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-07-28
    Description: The presence of polyunsaturated and saturated fatty acids in leukocytic membranes prompted study of their possible role in the induction of brain edema. Polyunsaturated fatty acids including sodium arachidonate, sodium linoleate, sodium linolenate, and docasahexaenoic acids induced edma in slices of rat brain cortex. This cellular edema was specific, since neither saturated fatty acids nor a fatty acid containing a single double bond had such effect.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Chan, P H -- Fishman, R A -- New York, N.Y. -- Science. 1978 Jul 28;201(4353):358-60.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/663662" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Arachidonic Acids ; Brain Edema/*chemically induced ; Cerebral Cortex ; Detergents ; Dose-Response Relationship, Drug ; *Fatty Acids, Unsaturated ; Granulocytes/physiology ; Hydroxy Acids ; In Vitro Techniques ; Prostaglandins ; Rats ; Sodium Dodecyl Sulfate ; Water-Electrolyte Imbalance/chemically induced
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 9
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    Serotonin shifts the phase of the circadian rhythm from the Aplysia eye (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-12-01
    Description: A putative neurotransmitter, serotonin, may be used to transmit temporal information in the eye of Aplysia, because it can shift the phase of the circadian rhythm of spontaneous optic nerve impulses from the eye and the eye contains a significant quantity of serotonin. Serotonin acts either directly on the cell, or cells, containing the circadian pacemaker or on cells electronically coupled to the pacemaker cells.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Corrent, G -- McAdoo, D J -- Eskin, A -- New York, N.Y. -- Science. 1978 Dec 1;202(4371):977-9.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/309655" target="_blank"〉PubMed〈/a〉
    Keywords: 5-Hydroxytryptophan/pharmacology ; Animals ; Aplysia ; Circadian Rhythm/*drug effects ; Dopamine/pharmacology ; Eye/metabolism ; In Vitro Techniques ; *Ocular Physiological Phenomena ; Serotonin/metabolism/*pharmacology
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
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  • 10
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    Presynaptic alpha-receptor subsensitivity after long-term antidepressant treatment (1978)
    American Association for the Advancement of Science (AAAS)
    Details
    Publication Date: 1978-10-20
    Description: After 3 weeks of twice-daily administration of desipramine to rats, the frequency-response curve for field stimulation of adrenergic neurons in isolated left atrial strips was shifted markedly to the left and the efflux of [3H]norepinephrine was enhanced greatly. After 1 day of treatment, only slight shifts in the frequency-response curve and small increases in [3H]norepinephrine efflux occurred although inhibition of [3H]norepinephrine uptake was already maximal, and phenoxybenzamine caused a further shift to the left in the frequency-response curve similar to that which occurred after 3 weeks of desipramine treatment alone. A gradual decrease in the sensitivity of the presynaptic alpha receptor would explain the delay in the onset of the linical effect of the tricyclic antidepressants.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Crews, F T -- Smith, C B -- New York, N.Y. -- Science. 1978 Oct 20;202(4365):322-4.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/211589" target="_blank"〉PubMed〈/a〉
    Keywords: Animals ; Desipramine/*pharmacology ; In Vitro Techniques ; Kinetics ; Neuromuscular Junction/drug effects ; Norepinephrine/*metabolism/pharmacology ; Phenoxybenzamine/pharmacology ; Rats ; Receptors, Adrenergic/*drug effects ; Receptors, Adrenergic, alpha/*drug effects ; Receptors, Adrenergic, beta/drug effects ; Synaptic Membranes/drug effects ; Synaptic Transmission/*drug effects ; Time Factors
    Print ISSN: 0036-8075
    Electronic ISSN: 1095-9203
    Topics: Biology , Chemistry and Pharmacology , Computer Science , Medicine , Natural Sciences in General , Physics
    Published by American Association for the Advancement of Science (AAAS)
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