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  • Articles  (71)
  • liver  (50)
  • Chlorella
  • Springer  (71)
  • American Institute of Physics
  • Cell Press
  • 2010-2014
  • 2005-2009
  • 1985-1989  (28)
  • 1975-1979  (43)
  • 1945-1949
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  • 1989  (28)
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  • Biology  (71)
  • Nature of Science, Research, Systems of Higher Education, Museum Science
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  • Articles  (71)
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  • 2010-2014
  • 2005-2009
  • 1985-1989  (28)
  • 1975-1979  (43)
  • 1945-1949
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  • 1
    Electronic Resource
    Electronic Resource
    The effects of vitamin A nutritional status on microsomal lipid peroxidation and α-tocopherol level in rat liver (1989)
    Springer
    Cellular and molecular life sciences 45 (1989), S. 342-343 
    Details
    ISSN: 1420-9071
    Keywords: Vitamin A ; vitamin E ; liquid peroxidation ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In vitamin A-deficient rats, liver glutathione peroxidase activity was decreased, α-tocopherol content was strongly enhanced, but microsomal liquid peroxidation remained unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01957471
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  • 2
    Electronic Resource
    Electronic Resource
    Photoregulation of transfer and 5S ribosomal RNA synthesis in Chlorella (1977)
    Springer
    Planta 137 (1977), S. 139-144 
    Details
    ISSN: 1432-2048
    Keywords: Chlorella ; Chloroplast ; Light regulation ; Nucleus ; RNA synthesis ; Transcription
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract The effect of blue and red light on the synthesis of transfer and 5S ribosomal RNA in autotrophic cultures of Chlorella pyrenoidosa was studied by pulse labeling experiments with tritiated guanosine. Compared with darkness or red light (679 nm), blue light (457 nm) of low intensities (quantum flux: 0.5–5×10−10 mol photons cm−2 s−1) stimulated incorporation of guanosine into transfer and 5S ribosomal RNA within the first 5 min of illumination. This blue light effect was abolished by cycloheximide, an inhibitor of protein synthesis on 80S ribosomes, but not by rifampicin, an inhibitor of chloroplastic transcription, nor by lincomycin, an inhibitor of chloroplastic translation. The rifampicin-insensitive synthesis of transfer and 5S ribosomal RNA was nuclear transcription as shown by RNA-DNA hybridization. The blue light effect on nuclear RNA synthesis was not inhibited by 3-(3,4-dichlorophenyl)-1,1-dimethyl-urea, an inhibitor of photosynthesis electron transport. Further evidence for a photosynthesis-independent photocontrol of RNA synthesis was provided by experiments with the colorless mutant 125a of Chlorella vulgaris. Blue light stimulated incorporation of guanosine into cytoplasmic 25S and 18S ribosomal RNA as well as into transfer and 5S ribosomal RNA, whereas incorporation in red light was the same as that of the dark control.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387550
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of permeant acids and bases on net potassium uptake by Chlorella (1978)
    Springer
    Planta 138 (1978), S. 243-248 
    Details
    ISSN: 1432-2048
    Keywords: Chlorella ; Permeant acids and bases ; pH-stat ; Potassium uptake ; Proton transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Salts of membrane-permeant acids and bases strongly influence net K uptake by Chlorella fusca. Na phenylacetate, acetate, isobutyrate, propionate, and butyrate added to buffered algal suspensions containing 0.1–0.2 mM KCl increasingly stimulated net K uptake. In contrast, K release was induced by the chlorides of imidazole, ammonia and methylamine. All these effects were found in the light and, less pronounced, in the dark. The dependence of the net K movements on the concentrations of the salts added and on the pH of the medium suggests that the free acids or bases are the effective agents. Between net uptake of K and uptake of labeled propionate a molar ratio close to 1 was found. It is concluded that the internal pH of the cell is changed by the permeants. Acidification of the cytoplasm stimulates extrusion of protons coupled to uptake of K. Alcalization brings about proton uptake and K extrusion. Apparently K/H exchange serves as a pH-stat of the cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386818
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  • 4
    Electronic Resource
    Electronic Resource
    Nitrate reductase of Chlorella fusca: Partial purification, cytochrome content and presence of HCN after in vivo inactivation (1978)
    Springer
    Planta 141 (1978), S. 323-328 
    Details
    ISSN: 1432-2048
    Keywords: Chlorella ; Cyanide ; Cytochrome b557 ; Nitrate reductase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract An inactivated nitrate reductase (EC 1.6.6.1) formed in vivo by the green alga Chlorella fusca Shihira and Kraus is shown to be a cyanide complex. The partially purified inactive enzyme releases 0.048 nmol of HCN per unit of enzyme activated. This compares with 0.066 nmol of HCN liberated in similar previous measurements with the inactivated enzyme from Chlorella vulgaris. The nitrate reductase from C. fusca has been purified to a level of 67 μmol nitrate reduced per min per mg enzyme. It contains a cytochrome b557, at a level 1.9-fold higher per unit of active enzyme, than the nitrate reductase from C. vulgaris.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388351
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of ammonium and ferricyanide on nitrate utilization by Chlorella vulgaris (1978)
    Springer
    Planta 141 (1978), S. 279-282 
    Details
    ISSN: 1432-2048
    Keywords: Ammonium ; Chlorella ; Ferricyanide ; Nitrate reductase ; HCN-Inactivation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract It has been shown previously that added ammonium salts cause a cessation of nitrate utilization in some Chlorella species. It has also been shown that Chlorella vulgaris can form an inactivated nitrate reductase which is an HCN complex. In the present study, a comparison has been made of the rate of nitrate utilization and the rate of nitrate reductase inactivation in Chlorella vulgaris in response to the addition of ammonium salts and light-dark changes. The rate of formation of HCN-inactivated enzyme is too slow to account for the prompt inhibition of nitrate utilization caused by adding ammonium. In contrast, when nitrate utilization is inhibited by addition of ferricyanide to intact cells, the HCN-inactivated enzyme is promptly formed in vivo, and might account for the inhibition of nitrate utilization, though inhibition of nitrate uptake can not be excluded.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388344
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  • 6
    Electronic Resource
    Electronic Resource
    Sulfite: Preferential sulfur source and modifier of CO2 fixation in Chlorella vulgaris (1978)
    Springer
    Planta 143 (1978), S. 225-231 
    Details
    ISSN: 1432-2048
    Keywords: Chlorella ; CO2 fixation ; Growth yield ; Methionine ; O2 evolution ; Sulfolipids ; Sulfite action
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Sulfite was added at the time of inoculation to a standard and to a sulfate deficient medium of Chlorella vulgaris. It was not only used as a sulfur source, but besides this, at concentrations 〈1.0 mmol l−1, the growth yield was enhanced up to 30% compared to sulfate saturated conditions. Higher sulfite concentrations increasingly inhibited cell growth. Growth rate determinations indicated that the enhancement, and the inhibition respectively, were confined to the very beginning of culture growth; the time period during which the sulfite was not yet oxidized (5–10 h). In contrast, an increased CO2 fixation rate/unit of protein, occurring up to 5.0 mmol l−1 sulfite and a shift towards the β-carboxylation pathway, are persisting at least during the growth period of 4 days. The preferential uptake of sulfite, also indicated by a marked increase in methionine content of algal protein, presumably causes an increase in thylakoidal sulfolipids, and is such modifying the CO2 fixation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387793
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  • 7
    Electronic Resource
    Electronic Resource
    Incorporation of 14CO2 in prenylquinones of Chlorella pyrenoidosa (1978)
    Springer
    Planta 141 (1978), S. 253-258 
    Details
    ISSN: 1432-2048
    Keywords: Chlorella ; Photosynthesis (prenylquinone synthesis) ; Prenylquinones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Incorporation and release of 14C-label in prenylquinones of Chlorella was investigated under steady state conditions. After one hour of 14CO2-photosynthesis all plastid quinones investigated were labeled. The highest label was found in phylloquinone (18%) while α-tocopherol exhibits the lowest label (0.38%). Among the plastoquinones, plastohydroquinone-9 shows a higher labeling degree (5.1%) and a faster labeling kinetic than plastoquinone-9 (1.6%). After replacement of 14CO2 against 12CO2 the total radioactivity in plastohydroquinone-9, α-tocopherol and phylloquinone decreases but in α-tocoquinone and plastoquinone-9 proceeds further. From this labeling kinetic we conclude, that newly synthesized [14C]α-tocopherol molecules are converted to [14C]α-tocoquinone and [14C]plastohydroquinone-9 molecules to [14C]plastoquinone-9. From their 14C-incorporation kinetic half-lives could be calculated for all prenylquinones in the same ranges as previously found for the chlorophylls and carotenoids (Grumbach et al., 1978). Half-lives are shorter in plastohydroquinone-9 (30 min) and plastoquinone-9 (40 min) than in phylloquinone (55 min), α-tocoquinone (50 min) and α-tocopherol (220 min). This means that all prenyl-lipids such as chlorophyll a, α-and β-carotene, plastohydroquinone-9 and plastoquinone-9 which are more directly involved in the process of photosynthesis are subject to a continuous and higher turnover than the xanthophyll and α-tocopherol. From the fast labeling kinetic and short half-lives of α-tocoquinone and especially phylloquinone with a labeling degree of 12% after one hour of 14CO2 photosynthesis we suppose that perhaps these two prenylquinones are also involved in the photosynthetic activity of chloroplasts.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388340
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  • 8
    Electronic Resource
    Electronic Resource
    Incorporation of 14CO2 in photosynthetic pigments of Chlorella pyrenoidosa (1978)
    Springer
    Planta 140 (1978), S. 37-43 
    Details
    ISSN: 1432-2048
    Keywords: Carotenoids ; Chlorophylls ; Chlorella ; Photosynthetic pigments ; Turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Tracer kinetic studies of chloroplast pigments of Chlorella pyrenoidosa were carried out in a special steady-state apparatus which allowed the simultaneous recording of oxygen evolution, CO2-fixation and 14CO2-incorporation. A special cylindrical vessel which permits labeling experiments with larger algae suspensions (800 ml) is described.-1. After 2 h of 14CO2-photosynthesis (fixation rate 100–160 μmol CO2/μmol chlorophyllxh) 3.3% of the total 14C-uptake (5.66 mCi) was found in the Chlorella lipid fraction. Total and specific radioactivity were higher in total carotenoids than in the chlorophylls. Chlorophyll a gave a higher labeling degree (2.4%) than chlorophyll b (1.3%).-2. Among the carotenoids α-and β-carotene were labeled after 2 h 14CO2 exposure with the same specific radioactivity and with a particular high labeling degree of c. 19%. The xanthophylls exhibit lower labeling degree (violaxanthin 5.1%, zeaxanthin 1.9%, lutein 1.4%, antheraxanthin 1.3%, and neoxanthin 0.7%).-3. During the 4 h 12CO2-exposure period, which followed the 2 h 14CO2-incorporation time, the specific and total radioactivity of the α-and β-carotene pools decrease with a concomitant increase in the α-ionone-(lutein) and β-ionone xanthophylls (violaxanthin, zeaxanthin, antheraxanthin). The possibility, that the decrease of 14C label in the carotenes may in part be due to a photo-oxidative degradation, is discussed.-4. Calculation of biological half-life-times from the 14C-incorporation kinetics during the first hour of the experiment, when the pigment concentration is almost unchanged, results in times from 30 to 60 min. Half lives are shorter in the precursor pools such as chlorophyll a (30 min), α-carotene (40 min) and β-carotene (50 min) and violaxanthin (60 min) respectively.
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    URL: http://dx.doi.org/10.1007/BF00389377
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  • 9
    Electronic Resource
    Electronic Resource
    Studies on Chlorella protoplasts (1978)
    Springer
    Planta 139 (1978), S. 257-260 
    Details
    ISSN: 1432-2048
    Keywords: Cell wall staining ; Cell wall regeneration ; Chlorella ; Protoplasts
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Protoplasts of Chlorella saccharophila (Krüger) Nadson were obtained by cellulase digestion of the microfibrillar inner compount of the cell wall after the resistant outermost layer had been scratched with sea sand. The absence of the cell wall was demonstrated immunologically, electron microscopically and by staining, thus confirming the protoplastic nature of the treated cells. After transfer to an enzyme-free medium regeneration of a thin cell wall was observed. The regeneration of the cell wall obviously followed the same steps as does the cell wall development of the autospores. At least 50% of the protoplasts were able to form colonies when plated on a suitable agar medium.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00388638
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  • 10
    Electronic Resource
    Electronic Resource
    The cell content and secretion of water-soluble vitamins by several freshwater algae (1977)
    Springer
    Archives of microbiology 112 (1977), S. 57-59 
    Details
    ISSN: 1432-072X
    Keywords: Water soluble vitamins (secretion, cell content) ; Chlamydomonas ; Chlorella ; Scenedesmus ; Anabaena
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Three green algae, Chlamydomonas reinhardii, Chlorella vulgaris and Scenedesmus obliquus, and one blue-green alga, Anabaena cyclindrica, were grown in chemically defined media. All the algac examined contained folates, β-carotene and vitamins C and E; several of the B-vitamins and vitamin A were found in varying amounts in some but not in all the algae examined. All the green algae secreted significant amounts of folate and biotin and all but Scenedesmus secreted pantothenate into their growth medium; Anabaena secreted folate and pantothenate.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00446654
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  • 11
    Electronic Resource
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    Physiological and biochemical contributions to the taxonomy of the genus prototheca (1977)
    Springer
    Archives of microbiology 113 (1977), S. 139-141 
    Details
    ISSN: 1432-072X
    Keywords: Biochemical taxonomy ; Prototheca ; Chlorella ; Hydrogenase ; Acid tolerance ; Salt tolerance ; Sodium chloride ; Thermophily ; Gelatin liquefaction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Five physiological and biochemical characters, which had proved to be valuable for the taxonomy of the genus Chlorella, were studied in the genus Prototheca. There is no hydrogenase activity and no liquefaction of gelatin. Most strains are very acidtolerant (limit of growth at pH 2.0 or 2.5) and very salt-tolerant (limit of growth at 4 or 5% NaCl). Two strains grow well at 38°C. The 16 strains, which were previously assigned to seven taxa, fall into four different groups. Our results tend to support the assumption that Prototheca might be related to Chlorella protothecoides.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428593
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  • 12
    Electronic Resource
    Electronic Resource
    Physiological and biochemical contributions to the taxonomy of the genus Chlorella (1978)
    Springer
    Archives of microbiology 119 (1978), S. 13-16 
    Details
    ISSN: 1432-072X
    Keywords: Biochemical taxonomy ; Chlorella ; Starch hydrolysis ; Amylase ; Extracellular enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Starch hydrolysis, i.e., the production of extracellular amylolytic enzymes, was found to be a specific character for most species of the genus Chlorella. C. fusca var. vacuolata, C. spec. 211-30, and C. spec. 211-11r hydrolyse starch, whereas C. vulgaris, C. fusca var. rubescens, C. zofingiensis, C. fusca var. fusca, C. minutissima, C. homosphaera, C. kessleri, C. luteoviridis, and C. protothecoides are unable to hydrolyse starch. Only C. sorokiniana and C. saccharophila appear heterogenous; within C. sorokiniana, 7 strains hydrolyse starch and 9 do not; and within C. saccharophila, 6 strains exhibit amylolytic activity and 2 do not. — A key for the identification, according to 9 easily determined physiological and biochemical characters, of the Chlorella species is presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00407921
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  • 13
    Electronic Resource
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    The cryopreservation ofChlorella (1978)
    Springer
    Archives of microbiology 119 (1978), S. 153-156 
    Details
    ISSN: 1432-072X
    Keywords: Chlorella ; Cryopreservation ; Fatty acids analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Following growth under sub-optimal concentrations of nutrients, cells ofChlorella emersonii accumulated lipid and became more resistant to the damage caused by freezing and thawing. These results suggest that the factor responsible for the cold hardening of someChlorella spp is not the effect of low temperatures per se but simply that of the reduced metabolic rate. Evidence is given that the post-thaw injury observed following rapid rates of cooling is associated with the vacuole.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964266
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  • 14
    Electronic Resource
    Electronic Resource
    Physiological and biochemical contributions to the taxonomy of the genus Chlorella (1978)
    Springer
    Archives of microbiology 116 (1978), S. 97-103 
    Details
    ISSN: 1432-072X
    Keywords: Biochemical taxonomy ; Chlorella ; DNA hybridization ; DNA homology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 1. DNA homology was studied in 12 Chlorella species. The DNA of 88 strains was hybridized with 3H-labelled DNA from C. fusca var. vacuolata 211-8b and from C. vulgaris 211-8m. The results indicate that the genus Chlorella is a heterogenous taxon which consists of several groups of species. 2. The “C. fusca group” comprises C. fusca var. vacuolata, C. fusca var. rubescens, and C. zofingiensis. Within this group, C. zofingiensis appears to be more closely related to C. fusca var. vacuolata than is C. fusca var. rubescens. C. fusca var. fusca does not belong to this group of taxa. 3. The “C. vulgaris group” consists of C. vulgaris, C. sorokiniana, and C. saccharophila. There are several strains which seem to assume a position intermediate between C. vulgaris and C. saccharophila. C. protothecoides is not related to this group of species. 4. Several groups of strains of C. sorokiniana with different base compositions (guanine + cytosine content) of their DNA appear to belong to the same taxon. 5. In addition to C. fusca var. fusca and C. protothecoides, also C. luteoviridis, C. minutissima, C. kessleri, and C. homosphaera seem to have so little relationship with the other species that their assignment to the genus Chlorella appears questionable.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00408739
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  • 15
    Electronic Resource
    Electronic Resource
    The cryopreservation of Chlorella (1977)
    Springer
    Archives of microbiology 114 (1977), S. 249-254 
    Details
    ISSN: 1432-072X
    Keywords: Chlorella ; Cryopreservation ; Fatty acid analysis ; Preeze-fracture electron microscopy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Following a shift from autotrophic to heterotrophic nutrition, cells of Chlorella protothecoides become sensitive to the stresses of freezing and thawing. The injury then observed at slow rates of cooling cannot be explained by the cellular response to hypertonic solutions, and at faster cooling rates intracellular ice formation was not demonstrated to be damaging. These findings are at variance with suggested mechanisms of injury in other cellular systems. The results are compared with alterations in ultrastructure and in the composition of the cellular fatty acids.
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    URL: http://dx.doi.org/10.1007/BF00446869
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  • 16
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    Physiological and biochemical contributions to the taxonomy of the genus Prototheca (1978)
    Springer
    Archives of microbiology 116 (1978), S. 105-107 
    Details
    ISSN: 1432-072X
    Keywords: Biochemical taxonomy ; Prototheca ; Chlorella ; Starch hydrolysis ; DNA ; Base composition ; GC content
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract 16 strains of the genus Prototheca do not produce extracellular amylolytic enzymes. The base composition of their DNA shows rather continuous values from 62% to 78% GC (guanine + cytosine). Their assignment to four species and their possible relationship with Chlorella protothecoides are discussed.
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    URL: http://dx.doi.org/10.1007/BF00408740
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  • 17
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    Effects of warm and cold ischemia on mitochondrial functions in brain, liver and kidney (1989)
    Springer
    Molecular and cellular biochemistry 87 (1989), S. 137-145 
    Details
    ISSN: 1573-4919
    Keywords: mitochondria ; brain ; liver ; kidney ; ischemia ; hypothermia
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract The purpose of this work was to study the effects of warm (37°C) and cold (4°C) ischemia on different mitochondrial functions in rat brain, liver and kidney. After l0 to 60 minutes of ischemia at 37°C the energy coupled respiration as well as the ADP-induced malate-aspartate shuttle activity in brain and liver mitochondria or the rate of mitochondrial ATP synthesis in kidney were significantly decreased. However, the respiratory rates and the shuttle activity in the absence of ADP remained unchanged. These data suggest that ischemia primarily affects electron transport in the respiratory chain rather than the hydrogen shuttle and the energy coupling system. When the temperature during the indicated ischemic periods was decreased to 4°C, in brain and liver no significant alterations of these mitochondrial functions were found in comparison with the non-ischemic controls. When rat kidneys were stored for 36 hours at 4°C according to Collins mimicing transplantation conditions, the mitochondrial respiration and ATP synthesis were only slightly decreased. It therefore appears that hypothermia can prevent effectively mitochondrial dysfunction due to ischemia.
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    URL: http://dx.doi.org/10.1007/BF00219256
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  • 18
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    Purification, cloning and nucleotide sequence determination of cynomolgus monkey apolipoprotein C-11: comparison to the human sequence (1989)
    Springer
    Molecular and cellular biochemistry 90 (1989), S. 69-79 
    Details
    ISSN: 1573-4919
    Keywords: protein purification ; lipoprotein ; isoelectric focusing ; immunoblotting ; liver ; cDNA library
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Abstract We have purified apolipoprotein C-II (apo C-II) from cynomolgus monkey plasma, prepared antibody against it and used the antibody to isolate a cDNA containing the complete coding sequence for cynomolgus monkey apo C-11. Sequence analysis indicated that the monkey apo C-11 cDNA was 200 by longer than the human and the difference in size was all in the 5° untranslated region of the mRNA. This was confirmed by Northern analysis of human and monkey RNA. There was an open reading frame in the monkey apo C-11 cDNA sequence encoding a preprotein of 101 amino acids — identical in size to the human protein. The carboxyl terminal 44 amino acids of the protein were 100% homologous to the human apo C-11 amino acid sequence indicating evolutionary conservation of both structure and function. However, the amino terminal 35 amino acids of the protein were only 75% homologous and the amino terminal 19 amino acids were only 58% homologous to the human sequence. The amino acid sequence derived from the nucleotide sequence predicts a more basic protein than the human apo C-11 and this is confirmed by isoelectric focusing and immunoblotting.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225222
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  • 19
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    Genetics of aryl hydrocarbon hydroxylase induction in mice: Response of the lung to cigarette smoke and 3-methylcholanthrene (1977)
    Springer
    Biochemical genetics 15 (1977), S. 723-740 
    Details
    ISSN: 1573-4927
    Keywords: aryl hydrocarbon hydroxylase, gene loci controlling ; cigarette smoke ; mice ; lung ; liver ; 3-methylcholanthrene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract When mice from different inbred strains are injected intraperitoneally with 3-methylcholanthrene (MC), the activity of aryl hydrocarbon hydroxylase (AHH) rapidly increases in livers of some strains but not others. AHH plays a role in the metabolism of polycyclic hydrocarbons. Alleles at a small number of loci account for most of the variation in inducibility of hepatic AHH among mice, when MC is used as the inducing agent. Cigarette smoke is a common source of carcinogenic polycyclic hydrocarbons in the environment. Since some of the hydrocarbons in cigarette smoke are metabolized by AHH, the activity of AHH in tissues may affect the carcinogenicity of smoke in those tissues. The purpose of these experiments was to see whether induction of AHH in lung in response to cigarette smoke is regulated by the same genes that regulate induction of AHH in liver in response to MC. Mouse strains AKR/J and C57L/J and six recombinant inbred (RI) lines derived from them were tested for the response of AHH in lung and liver to parenteral MC or inhalation of cigarette smoke. Inducibility (the ratio of MC-induced AHH activities to basal AHH activities) in liver from MC-treated RI lines is bimodal and compatible with Mendelian segregation of genes at a small number of loci. Increased activities of AHH in MC-treated liver are associated with increased ability to metabolize BP and whole smoke condensates to mutagens detected by Salmonella typhimurium TA1538. Inducibility of AHH in lung in response to MC is not bimodal, and no definite conclusion about the number of loci can be made. When actual levels of AHH activity are considered, following the administration of MC as inducing agent, there is a correlation (r=0.89, p〈0.01) between AHH levels in liver and lung, suggesting that some genes affecting liver also affect lung. Basal and MC-induced AHH levels in lung are also correlated (r=0.86, p〈0.01). Mice with high basal activities have two to threefold higher levels of AHH after MC treatment than do mice with low basal activities. Induction of AHH in pulmonary tissues occurs in all mice after either parenteral MC or smoke inhalation. In contrast to MC treatment, AHH activities in lungs following smoke inhalation are not correlated with AHH levels in liver after MC (r=0.49) and are only weakly correlated with basal (r=0.66, 0.05〈p〈0.10) pulmonary levels. The correlation between MC-induced and smoke-induced AHH activities in lung is weak (r=0.63, 0.05〈p〈0.10). We conclude that the genetic regulation of AHH activity in lung is not as simple as the genetic regulation of AHH activity in liver, especially when complex inducing agents such as cigarette smoke are used.
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    An increase of collagen biosynthesis in livers of rats submitted to chronic intoxication with ethanol (1989)
    Springer
    Molecular and cellular biochemistry 85 (1989), S. 43-48 
    Details
    ISSN: 1573-4919
    Keywords: alcohol ; intoxication ; collagen ; ethanol ; rat ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology , Medicine
    Notes: Summary It was found that chronic intoxication of rats with ethanol results in a dictinct, progressive increase of 53H-proline incorporation into collagen synthesized by liver. At the same time biosynthesis of other proline-containing proteins in rat liver slightly decreases. These effects precede the morphological symptoms of liver damage induced by ethanol.
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    Identification of thetrans-stilbene oxide-active glutathione transferase in human mononuclear leukocytes and in liver as GST1 (1989)
    Springer
    Biochemical genetics 27 (1989), S. 253-261 
    Details
    ISSN: 1573-4927
    Keywords: glutathione transferases ; genetics ; liver ; blood ; leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A glutathione transferase from human mononuclear leukocytes with a high activity towardtrans-stilbene oxide (GT-tSBO) has been studied in liver and blood from fetus and adults and in blood from neonates. Using starch gel electrophoresis, different phenotypes of GST1 have been determined, GST1 0, GST1 1, and GST1 2. As judged from activity measurements and the fact that only those individuals who express the null allele of GST1, the GST1 0, which has a low activity towardtrans-stilbene oxide, it is concluded that the hepatic transferase GST1 is identical to GT-tSBO, as well as to hepatic transferase μ. In addition, it has been shown that the different genotypes of GST1 1 (GST1 1-1, GST1 1-0) and GST1 2 (GST1 2-2, GST1 2-0) can be separated by measuring the GT-tSBO activity in whole blood from the same individual. It is also demonstrated that GT-tSBO activity is much lower in fetal liver, approximately 10 times, compared with adult liver, while this activity seems to be unchanged in the blood from fetus and adults, as well as in neonates.
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  • 22
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    Identification of thetrans-stilbene oxide-active glutathione transferase in human mononuclear leukocytes and in liver as GST1 (1989)
    Springer
    Biochemical genetics 27 (1989), S. 253-261 
    Details
    ISSN: 1573-4927
    Keywords: glutathione transferases ; genetics ; liver ; blood ; leukocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract A glutathione transferase from human mononuclear leukocytes with a high activity towardtrans-stilbene oxide (GT-tSBO) has been studied in liver and blood from fetus and adults and in blood from neonates. Using starch gel electrophoresis, different phenotypes of GST1 have been determined, GST1 0, GST1 1, and GST1 2. As judged from activity measurements and the fact that only those individuals who express the null allele of GST1, the GST1 0, which has a low activity towardtrans-stilbene oxide, it is concluded that the hepatic transferase GST1 is identical to GT-tSBO, as well as to hepatic transferase μ. In addition, it has been shown that the different genotypes of GST1 1 (GST1 1-1, GST1 1-0) and GST1 2 (GST1 2-2, GST1 2-0) can be separated by measuring the GT-tSBO activity in whole blood from the same individual. It is also demonstrated that GT-tSBO activity is much lower in fetal liver, approximately 10 times, compared with adult liver, while this activity seems to be unchanged in the blood from fetus and adults, as well as in neonates.
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    Evidence for a plasma-membrane-bound nitrate reductase involved in nitrate uptake of Chlorella sorokiniana (1989)
    Springer
    Planta 178 (1989), S. 19-24 
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    ISSN: 1432-2048
    Keywords: Chlorella ; Nitrate reductase (plasma membrane bound) ; Nitrate uptake ; Plasma membrane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Anti-nitrate-reductase (NR) immunoglobulin-G (IgG) fragments inhibited nitrate uptake into Chlorella cells but had no affect on nitrite uptake. Intact anti-NR serum and preimmune IgG fragments had no affect on nitrate uptake. Membrane-associated NR was detected in plasma-membrane (PM) fractions isolated by aqueous two-phase partitioning. The PM-associated NR was not removed by sonicating PM vesicles in 500 mM NaCl and 1 mM ethylenediaminetetraacetic acid and represented up to 0.8% of the total Chlorella NR activity. The PM NR was solubilized by Triton X-100 and inactivated by Chlorella NR antiserum. Plasma-membrane NR was present in ammonium-grown Chlorella cells that completely lacked soluble NR activity. The subunit sizes of the PM and soluble NRs were 60 and 95 kDa, respectively, as determined by sodium-dodecyl-sulfate electrophoresis and western blotting.
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    URL: http://dx.doi.org/10.1007/BF00392522
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    Changes in pigment content, lipid pattern and ultrastructure of synchronous Chlorella after heat and cold shocks (1978)
    Springer
    Planta 139 (1978), S. 29-33 
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    ISSN: 1432-2048
    Keywords: Carotenoids ; Chlorella ; Chlorophyll ; Chloroplasts ; Lipids ; Temperature shocks ; Thylakoids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Completely synchronous Chlorella cultures were treated with heat (45°C) or cold shocks (4° C) of different lengths at the sixth hour of the 14:10 h lightdark-cycle. After the treatment the cells were grown under normal conditions. Analysis at the end of the cycle showed a direct connection between pigment bleaching, reduction of lipid content, loss of thylakoid stacking and a shift of the fluorescence emission maximuminto a region of shorter wavelength. The thylakoid stacking was completely loosened after a heat shock while two thylakoids remained in contact after cold treatment. This probably explains the different regeneration capacities in temperature shock treated cells. None of the described effects could be observed directly after the shocks. From the parallel decay of chlorophyll a, monogalactosyl diglyceride and carotenoids an intimate correlation with the photosystem II complex is suggested.
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  • 25
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    Effects of monensin on ATP levels and cell functions in rat liver and lung in vitro (1989)
    Springer
    The journal of membrane biology 108 (1989), S. 235-246 
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    ISSN: 1432-1424
    Keywords: monensin ; cell ATP ; cell ions ; water ; liver ; lung ; fetal liver ; fetal lung
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Summary Effects of the proton-alkali cation-exchanging ionophore, monensin, on aspects of cellular metabolism and ionic exchanges have been studied in rat tissues in vitro. Incubation of liver slices at 38°C with 0.1 μm monensin induced timedependent vesiculation, initially in the Golgi region, reduction of ATP content and of protein synthesis. At 1 νm, monensin also reduced net, active movements of K+, Na+, Cl− and water in liver slices and inhibited state 3 respiration in isolated mitochondria. The respiratory inhibitor, amytal, similarly reduced ATP content and protein synthesis at concentrations lower than those inhibiting ion transport in slices. Low concentrations of monensin (0.1–1.0 μm) had similar effects on ATP and ion transport in slices of adult lung. By contrast, late-fetal liver and lung were much less sensitive to monensin; in these tissues, glycolysis sustained substantial levels of ATP. Monensin also induced vesiculation of the Golgi apparatus in fetal lung cells. It is concluded that by lowering ATP levels, monensin can markedly alter various metabolic activities in those cells which depend primarily on oxidative phosphorylation for their metabolic energy.
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    Deoxyribonucleic acid reassociation and interspecies relationships of the genusChlorella (Chlorophyceae) (1989)
    Springer
    Plant systematics and evolution 168 (1989), S. 71-82 
    Details
    ISSN: 1615-6110
    Keywords: Algae ; Chlorococcales ; Chlorophyceae ; Chlorella ; Scenedesmus ; Taxonomy ; phylogeny ; DNA reassociation ; DNA/DNA hybridization ; DNA homology ; DNA base composition ; thermal stability
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Phylogenetic relationships within the genusChlorella were studied by means of DNA/DNA hybridization under both optimal and relaxed reassociation conditions as well as by determination of the thermal stability of hybrid DNA duplexes. The results indicate a relationship betweenC. fusca var.fusca, C. fusca var.rubescens, C. fusca var.vacuolata, and the genusScenedesmus. In addition, the strains endosymbiotic withParamecium bursaria seem to be related with theC. vulgaris/sorokiniana group. The relations between most other species, however, could not be sufficiently resolved by the above methods. This implies considerable phylogenetic divergency within the genusChlorella.
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    Effect of benzo(a)pyrene on monolayer cultures of normal and malignant mouse liver cells (1977)
    Springer
    Bulletin of experimental biology and medicine 84 (1977), S. 1331-1334 
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    ISSN: 1573-8221
    Keywords: benzo(a)pyrene ; liver ; hepatoma ; tissue culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cells of a monolayer culture of embryonic mouse liver, like cells of a culture of highly malignant hepatoma 22A, maintained by transplantation for 20 years, actively metabolized the carcinogenic hydrocarbon benzo(a)pyrene and are highly sensitive to its toxic action. Considering that liver tissue in vivo is resistant to carcinogenic hydrocarbons, the authors suggest that this resistance is due to factors acting at the organ or organism level but not at the cell level. The problem of the mechanism of preservation of the sensitivity of hepatoma 22A to the toxic action of benzo(a)pyrene also is discussed.
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    Effect of enteral oxygen therapy on liver function in acute degeneration (1977)
    Springer
    Bulletin of experimental biology and medicine 84 (1977), S. 1413-1415 
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    ISSN: 1573-8221
    Keywords: carbon tetrachloride ; oxygen ; liver ; bile acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of enteral oxygen therapy was studied in rats with acute degeneration of the liver caused by CCl4. Intragastric injection of oxygen foam reduced the severity of poisoning and led to more rapid and complete recovery of the intensity of bile secretion, synthesis of primary bile acids, and their conjugation with amino acids, and improved the stabilizing properties of the bile.
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    Effect of alcohol on hepatocyte mitochondria (1977)
    Springer
    Bulletin of experimental biology and medicine 84 (1977), S. 1783-1784 
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    ISSN: 1573-8221
    Keywords: mitochondria ; liver ; alcohol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Ultrastructural changes in the hepatocytes under the influence of alcohol were studied. The greatest changes were found in the mitochondria. Physical exertion and a low protein diet have a marked effect on the degree of alcohol poisoning. The first factor reduces whereas the second aggravates the harmful action of alcohol.
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    Method of combined histological staining of the liver with alcian blue and carbol fuchsin (1978)
    Springer
    Bulletin of experimental biology and medicine 85 (1978), S. 254-256 
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    ISSN: 1573-8221
    Keywords: liver ; hepatocytes ; alcian blue
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A modification of Novelli's combined histological staining method whereby the functional state of hepatocytes can be determined is suggested.
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    Some features of growth of an organ culture of the liver from mice infected with coxsackie A13 virus (1978)
    Springer
    Bulletin of experimental biology and medicine 85 (1978), S. 477-479 
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    ISSN: 1573-8221
    Keywords: Coxsackie A13 virus ; organ culture ; proliferation ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Features of growth and proliferation of organ cultures of the liver from noninbred albino mice infected with a single dose of Coxsackie A13 virus were investigated. A marked zone of growth mainly of epithelial cells was found early in explants of the liver of the experimental group of mice, whereas growth of cells around the liver explants of the control mice either was absent or was very weak. Moreover, many lymphocytes uniformly distributed in the zone of growth of the liver cells were found in preparations of the liver of the experimental mice. In some explants the picture of adhesion of lymphocytes to the hepatocytes of the culture was seen, and in places where lymphocytes accumulated death of the liver cells and marked thinning of the cellular layer were observed on the 21st and 28th days of growth of the culture.
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    Localization of albumin, transferrin, andα-fetoprotein in normal and regenerating mouse liver (1978)
    Springer
    Bulletin of experimental biology and medicine 85 (1978), S. 689-693 
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    ISSN: 1573-8221
    Keywords: α-fetoprotein ; albumin ; transferrin ; immunofluorescence ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A technique of tissue fixation with a mixture of acetone and formalin followed by embedding in paraffin wax, enabling good detection of antigens, including serum proteins, is described. By means of this method the distribution of albumin, transferrin, andα-fetoprotein was described in normal and regenerating mouse liver. Both under normal conditions and during regeneration albumin and transferrin are contained by strictly the same hepatocytes.α-Fetoprotein is found in the regenerating liver independently of the other two proteins, although it is found in the same zones. Albumin and transferrin are found only in the perinecrotic zone in each cell containingα-fetoprotein.
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    Immunohistochemical study of cardiolipin and phosphatidylinositol in mouse liver (1978)
    Springer
    Bulletin of experimental biology and medicine 86 (1978), S. 1206-1209 
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    ISSN: 1573-8221
    Keywords: immunofluorescence ; cardiolipin ; phosphatidylinositol ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The localization of phospholipid haptens (cardiolipin and phosphatidylinositol) in frozen and paraffin sections of mouse liver fixed in acetone and in an acetone-buffer-formalin mixture was studied by the indirect fluorescent antibodies method. Antiphospholipid sera specifically stained the plasma membranes of the hepatocytes, especially the region of the membrane facing the blood sinus. Detection of phospholipid haptens in liver sections with the aid of antiphospholipid sera depends on the method of obtaining and fixing the sections. Depending on the method of immunization, two types of antiphospholipid sera are obtained; they differ in their stability, in the possibility of isolating antibodies on lipid immunosorbents from them, and in their ability to stain liver sections.
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    Changes in rat liver mitochondria after bilateral subdiaphragmatic vagotomy (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 487-490 
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    ISSN: 1573-8221
    Keywords: mitochondrion ; liver ; vagotomy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Changes in the liver mitochondria of rats after bilateral subdiaphragmatic vagotomy were studied. Two stages were distinguished in the dynamics of the response of the mitochondrial system to denervation. During the first stage (0.5–3 days after vagotomy) reversible functional disturbances due to postoperative stress took place in the mitochondria. The second stage (7–60 days after denervation) is characterized by more marked structural and functional changes with some common features with those observed in hypoxia and resulting from vagotomy itself.
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    Effect of absence of polyploid hepatocytes on regeneration in the liver (1977)
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    Bulletin of experimental biology and medicine 84 (1977), S. 1183-1186 
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    ISSN: 1573-8221
    Keywords: liver ; polyploidy ; mitotic index ; index of labeled nuclei ; guinea pig
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract An autoradiographic study with [3H]thymidine showed that the hepatocytes of young sexually mature guinea pigs commence the phase of DNA synthesis 25 h after partial hepatectomy. Peaks of the number of labeled nuclei were found 30, 45, and 60 h after the operation. Two waves of mitoses were found by counting mitotic figures in squash preparations: 40 and 55 h after hepatectomy. A cytophotometric study of the DNA content showed that practically all the mononuclear and binuclear hepatocytes contained diploid nuclei 3 and 5 days after the operation. By the end of the 7th day of regeneration there were 6% of mononuclear tetraploid cells. The number of binuclear cells fell during the period of regeneration studied from 16 to 8%. It is concluded that the principal cytological mechanism of liver regeneration in guinea pigs is normal mitosis terminating in separation of the cells.
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    Effect of gnotobiotic conditions on the histophysiology of liver and spleen tissues (1978)
    Springer
    Bulletin of experimental biology and medicine 85 (1978), S. 95-98 
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    ISSN: 1573-8221
    Keywords: germfree animals ; liver ; spleen ; histochemical changes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The liver and spleen of gnotobiotic Wistar rats were studied by histochemical methods and the liver electron-microscopically. Under germfree conditions of existence of the animal the succinate dehydrogenase and nonspecific esterase activity in the liver decreased, fatty infiltration of the cytoplasm of the hepatocytes and Kupffer cells increased, and some of the cells developed fatty degeneration. Meanwhile acid phosphatase activity and the number of lysosomes increased in the biliary poles of the hepatocytes, whereas in the spleen destruction of erythrocytes and the liberation of free iron and pigments, which stimulate the excretion of bile in germfree animals, were increased.
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    Effect of o,p-dichlorodiphenyldichloroethane and perthane in vitro on glutathione reductase activity in the adrenals of dogs and guinea pigs (1978)
    Springer
    Bulletin of experimental biology and medicine 85 (1978), S. 152-154 
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    ISSN: 1573-8221
    Keywords: glutathione reductase ; o,p′-dichlorodiphenyldichloroethane ; p,p′-diethyldiphenyldi-chloroethane (Perthane) ; adrenals ; liver ; kidneys
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract o,p′-Dichlorodiphenyldichloroethane (o,p′-DDD) and Perthane, when added in a concentration of 312 μM to homogenate and cytoplasmic fraction of dog adrenals, activate glutathione reductase. In a concentration of 156 μM, o,p′-DDD and Perthane do not affect glutathione reductase activity of the dog adrenals. When given in vitro, o,p′-DDD and Perthane activate glutathione reductase of the guinea pig adrenals. o,p′-DDD has no effect on glutathione reductase activity of the cytoplasmic fraction of dog liver and kidney, thus confirming the high specificity of its effect on the adrenal cortex.
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    Effect of chronic carbon tetrachloride poisoning on the turnover of RNA fractions in rat liver tissue (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 490-494 
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    ISSN: 1573-8221
    Keywords: carbon tetrachloride ; liver ; RNA metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Changes in the content and incorporation of 5-3H-uridine after brief exposure to its labeled precursor were studied in the individual liver RNA fractions of rats during administration of carbon tetrachloride for 24 weeks. These fractions were obtained by preparative electrophoresis in 2.5% polyacrylamide gel from previously isolated nuclear and cytoplasmic RNA. Administration of CCl4 to rats was shown to reduce the quantity of transfer and ribosomal RNA in the liver tissue. Chronic CCl4 poisoning also disturbs the synchronization of the turnover of the individual components of fast-labeled RNA.
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    Tissue distribution of unusual rat estrogen-binding protein studied by immunoblotting (1989)
    Springer
    Bulletin of experimental biology and medicine 108 (1989), S. 1168-1171 
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    ISSN: 1573-8221
    Keywords: unusual estrogen-binding protein ; tissue distribution ; steroid hormones ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    URL: http://dx.doi.org/10.1007/BF00840667
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    Effect of strenuous physical exercise on destructive and reparative processes in the rat liver (1989)
    Springer
    Bulletin of experimental biology and medicine 108 (1989), S. 1239-1242 
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    ISSN: 1573-8221
    Keywords: liver ; hepatocyte ; physical exercise
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    Ultrastructural changes in the tissue-blood barrier in the liver in the early period after endotoxin injection (1989)
    Springer
    Bulletin of experimental biology and medicine 108 (1989), S. 1346-1349 
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    ISSN: 1573-8221
    Keywords: endotoxin ; liver ; ultrastructure ; endotheliocytes ; stellate reticuloendotheliocytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    Immunohistochemical study of insulin receptors of the liver (1989)
    Springer
    Bulletin of experimental biology and medicine 108 (1989), S. 1502-1505 
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    ISSN: 1573-8221
    Keywords: insulin ; insulin receptors ; liver ; regulation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    Some aspects of glycosylation in rat liver during pregnancy (1989)
    Springer
    Bioscience reports 9 (1989), S. 565-572 
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    ISSN: 1573-4935
    Keywords: glycoprotein ; dolichol ; glycosyl transferase ; liver ; pregnancy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The aim of the present report was to analyze the pattern of glycoprotein synthesis in rat liver on 19th and 22nd day of pregnancy by following the incorporation of14C-glucosamine and3H-galactose into isolated rat hepatocytes, the N-acetylglucosaminyl-1-P and galactosyl transferase activities, and the liver content of dolichol and dolichyl-phosphate. The data obtained show a decrease of precursor incorporation into glycoproteins during the last period of pregnancy; this decrease is independent of enzyme activities. The dolichol content increases and the dolichyl-phosphate content, usually considered as rate limiting for glycosylation, decreases. These results, present in other conditions of proliferation and differentiation of rat liver, could explain the differences in membrane organization, the increase of hepatic proteolysis and the alteration in secretory activity during the last phase of gestation.
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    Hepatic endothelial lipase activity in neonatal rat liver (1989)
    Springer
    Bioscience reports 9 (1989), S. 559-564 
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    ISSN: 1573-4935
    Keywords: lipase ; liver ; heparin perfusion ; hepatocytes ; hemopoietic cells ; neonate ; rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Hepatic endothelial lipase (HEL) activity is as high in the neonatal (1-day old) rat liver as in adults. Most of the HEL activity is located at the capillaries since 75% of the total activity is released by heparin or collagenase perfusion. The residual activity (non-releasable) is located in hepatocytes and not in hemopoietic cells, which are the major cell type in neonatal liver. Per mg of protein, the HEL activity is 50% higher in neonatal than in adult hepatocytes. We suggest that neonatal hepatocytes have an increased capacity to synthesize and secrete HEL activity, so maintaining a high activity in the whole organ. it might contribute to the hepatic uptake of cholesterol from circulating lipoproteins, in a period in which endogenous cholesterol synthesis is known to be inhibited in the liver.
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    Modulation of asialoglycoprotein binding activity in livers of pregnant or estrogen-treated rats (1989)
    Springer
    Bioscience reports 9 (1989), S. 701-707 
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    ISSN: 1573-4935
    Keywords: asialoglycoprotein ; receptor ; liver ; pregnant rat ; estrogen-treated rat
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract This report deals with the modulation of activity and expression of the hepatic asialoglycoprotein receptor, in pregnant or diethylstilbestrol-treated rats. The results show a two-fold increase in the total cell associated binding activity, both in pregnant and in estrogen-treated animals, with respect to normal values. On the contrary the surface expression was shown to be strongly enhanced only in the liver of pregnant rat. Therefore the modulation shown by this receptor system in pregnancy seems to be only partially estrogen-dependent.
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    Über denChlorella-Phycobionten vonTrapelia coarctata (1978)
    Springer
    Plant systematics and evolution 130 (1978), S. 253-263 
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    ISSN: 1615-6110
    Keywords: Lichens ; Trapeliaceae ; Trapelia coarctata ; Chlorophyta ; Oocystaceae ; Chlorella ; Cellular organization ; development
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Trapelia coarctata is lichenized withChlorella saccharophila var.ellipsoidea; this is in accordance with one of two former statements. The cells of the isolated alga may be covered individually by a gelatinous envelope; they also can be embedded in confluent mucilage. The course of succedanous divisions leading to the formation of autospores starts with the appearance of a second, new pyrenoid and goes on with bipartioning of the chloroplast, nuclear division and cytokinesis. Starch grains identical to those in the stroma surround the pyrenoid more or less loosely and not in the form of saucer-shaped parts constituting a coherent shell.
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    Identification of two forms of PFK and a fructose-2,6-bisphosphate independent form of PFP in a green alga (1989)
    Springer
    Photosynthesis research 21 (1989), S. 123-128 
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    ISSN: 1573-5079
    Keywords: fructose-2,6-bisphosphate ; PFK ; PFP ; Chlorella ; green algae ; carbon metabolism
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Cell-free preparations from the green alga, Chlorella pyrenoidosa, contained two forms of phosphofructokinase (PFK), designated PFK I and PFK II. This represents the first evidence for a second form of PFK in green algae. A pyrophosphate D-fructose-6-phosphate, 1-phosphotransferase (PFP) activity, that was unaffected by the regulatory metabolite, fructose-2,6-bisphosphate, co-purified with PFK II through several steps. The data suggest that Chlorella pyrenoidosa resembles higher plants in containing two forms of PFK, but differs in containing an atypical form of PFP.
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    Intensive rotifer cultures using chemostats (1989)
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    Hydrobiologia 186-187 (1989), S. 423-430 
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    ISSN: 1573-5117
    Keywords: Brachionus plicatilis ; production ; Chlorella ; Nannochloropsis ; fatty acids
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Continuous production of the rotifer Brachionus plicatilis rotundiformis (S-type) in an intensive chemostat culture system has been investigated. The production dynamics of rotifers in relation to different flow rates and feed regimes show that the growth rate and production depends on the type of algal feed and flow rate utilized in the culture system. It was possible to achieve a mean production of up to 318.84 × 106 rotifers m−3 d−1 at a flow rate of 6 1 h−1 in 100 1 chemostats and up to 261.21 × 106 rotifers m−3 d−1 at a flow rate of 40 1 h −1 while using 1 m3 capacity rotifer chemostats as production units. The ω 3 fatty acid composition of rotifers while using Chlorella and Nannochloropsis in the culture system has been described. The results of this investigation show that the rotifer productivity in the continuous culture system is considerably higher than in any of the conventional culture systems described to date for aquacultural purposes.
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    Creatine turnover in the starry flounder,Platichthys stellatus (1989)
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    Fish physiology and biochemistry 6 (1989), S. 1-9 
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    ISSN: 1573-5168
    Keywords: Platichthys stellatus ; creatine ; turnover ; phosphocreatine ; creatinine ; white muscle ; liver ; gills
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Starry flounder (Platichthys stellatus) were cannulated and a bolus of 9 μCi14C-creatine in saline was injected into the caudal vein. The fish were sacrificed at intervals ranging from 1h to 36d after label injection. Creatine pool size (PCr+Cr) and creatinine (Crn) content in blood, muscle, gills and liver were analyzed and specific activities (SA) determined. Mean concentrations of PCr+Cr/Crn in PCA-extracts of muscle, gills, liver and blood of experimental fish (at rest) were 38.1/2.40, 4.1/0.25, 5.6/0.45 and 0.3/n.d. μmol.g−1 respectively. Within 10 min, plasma SA had decreased by approximately 90%. In white muscle, the rate of14C−Cr appearance as well as label disappearance was slow compared to gills and liver. In fish examined 36d postinjection, mean SA in muscle had decreased to 23% of maximum SA which occurred 24h after injection.14C−Cr was incorporated into the liver tissue at a very high rate, SA being two orders of magnitude higher in liver than in white muscle. Over the first 6d, retention of label was observed in liver; after 36d only 3% of the original label was detected. Creatine pool size (PCr+Cr) in white muscle decreased with food deprivation. In flounder sacrificed after 36d, PCr+Cr was only 52% that of fed control fish, suggesting that creatine or precursors for its biosynthesis are supplied with the diet.
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    The liver parenchymal cells of rainbow trout (Salmo gairdneri) endocytose mannose-terminated glycoproteins (1989)
    Springer
    Fish physiology and biochemistry 6 (1989), S. 367-375 
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    ISSN: 1573-5168
    Keywords: rainbow trout ; liver ; endocytosis ; mannose receptor
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract A mannose-terminated glycoprotein,125I-invertase, was taken up and degraded by isolated rainbow trout liver cells at 12°C. The uptake was inhibited by EGTA and no degradation occurred in the presence of ammonium ions. The liver cell suspension was fractionated by differential centrifugation in parenchymal and nonparenchymal cells, respectively. The parenchymal liver cells seemed to be the most active cells in uptake of labelled invertase bothin vitro andin vivo. Only negligible amounts of ligand were recovered in the nonparenchymal cells. Internalization of125I-invertase at different temperatures was demonstrated indirectly by releasing surface-bound ligand with EGTA. Ligand was internalized even at 0°C in trout liver cells.In vitro uptake of125I-invertase was inhibited by excess unlabelled invertase, by mannan and by N-acetylglucosamine. These data suggest that invertase is endocytosed by a mannose-specific pathway by the parenchymal liver cells of rainbow trout.
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    Induction of metallothionein synthesis in rainbow trout,Salmo gairdneri, during long-term exposure to waterborne cadmium (1989)
    Springer
    Fish physiology and biochemistry 6 (1989), S. 221-229 
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    ISSN: 1573-5168
    Keywords: metallothionein ; rainbow trout ; cadmium ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Rainbow trout were exposed to 200 μg cadmium/l in the water during four months at 6–10°C. The liver, kidney and gills were analyzed for cadmium, copper, zinc, metallothionein and metallothionein mRNA. Cadmium accumulated in all three organs and reached the highest concentration in the kidney. The tissue zine and copper concentrations showed no major alterations during the experiment. The cytosolic distribution of cadmium, copper and zinc was followed during four months of exposure by Sephadex G-75 chromatography. It was found that cadmium was predominantly associated with proteins of an apparent molecular vieght of 10,000 daltons. These proteins were further identified as metallothioneins after fast protein liquid chromatography on a Mono-Q column. The metallothionein concentration was significantly higher in liver of exposed fish than in control fish after only one month. The kidneys reached significantly elevated levels of metallothionein in the exposed group after three months. In the gills, elevated metallothionein concentrations were observed after four months of exposure. After four months of exposure, the metallothionein mRNA content of liver and kidney was analyzed using a rainbow trout anti-sense RNA probe. Elevated MT mRNA levels were observed in both kidney and liver. These results demonstrate thatde novo synthesis of metallothionein is induced by cadmium in rainbow trout after exposure to the metalvia water.
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    Oxidoreductase activity of an unusual estrogen-binding protein of rat liver (1989)
    Springer
    Bulletin of experimental biology and medicine 107 (1989), S. 373-375 
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    ISSN: 1573-8221
    Keywords: unusual estrogen-binding protein ; oxidoreductase activity ; steroid hormones ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
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    Ultrastructural basis of intravascular thrombosis in the liver in obstructive jaundice (1989)
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    Bulletin of experimental biology and medicine 107 (1989), S. 417-421 
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    ISSN: 1573-8221
    Keywords: liver ; biliary cirrhosis ; intravascular blood clotting ; ultrastructure ; thrombus
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    Correction of metabolic disturbances in experimental cirrhosis of the liver by cryosurgical destruction and plasma flow resection (1989)
    Springer
    Bulletin of experimental biology and medicine 107 (1989), S. 698-701 
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    ISSN: 1573-8221
    Keywords: liver ; cirrhosis ; cryosurgical destruction ; metabolic disturbances
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    Effect of preliminary fasting on development of acute liver damage by D-galactosamine in rats (1989)
    Springer
    Bulletin of experimental biology and medicine 107 (1989), S. 38-41 
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    ISSN: 1573-8221
    Keywords: liver ; galactosamine hepatitis ; nutrition ; preliminary fasting
    Source: Springer Online Journal Archives 1860-2000
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    Effect of an atherogenic diet on age differences in cholesterol biosynthesis in the rat liver (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 143-145 
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    ISSN: 1573-8221
    Keywords: liver ; cholesterol biosynthesis ; age
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    Topics: Biology , Medicine
    Notes: Abstract After intraperitoneal injection of radioactive sodium acetate into rats of two age groups (6–8 and 28–32 months) the dynamics of cholesterol biosynthesis in the liver was observed to be slower in the older animals. The specific liver cholesterol activity of the older rats was lower at the maximum of uptake of the label than in the younger rats. An atherogenic diet for 20 days (0.25 g cholesterol/100 g body weight) led to an increase in the total cholesterol content but to inhibition of its biosynthesis in the liver, and this effect was most marked in the younger rats. Continued administration of cholesterol depressed its biosynthesis still more, especially in the older animals.
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    A multicomponent system of estradiol-binding proteins in rat liver cytosol and its dependence on sex steroids (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 647-650 
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    ISSN: 1573-8221
    Keywords: estrogens ; estradiol-binding proteins ; liver ; sex steroids
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    Topics: Biology , Medicine
    Notes: Abstract The marked sex differences in the ratio between the hormonal capacity of estradiol-binding components with Stokes' radii (a) of 7.0 and 2.5 nm observed in sexually mature animals are somewhat reduced but do not disappear completely after gonadectomy. Prolonged administration of estradiol (50 μg, 8days) to gonadectomized rats leads to depression of the estradiol-binding activity of all components of liver cytosol of females and males. Injection of testosterone propionate (2 mg, 8 days) into gonadectomized animals leads to selective stimulation of a special estrogen-binding protein with a=2.5 nm, normally characteristic of males alone, in both males and females. It is postulated that sex differences in the system of estradiol-binding proteins of the rat liver cytosol are due to sexual differentiation of the system in the early stages of development, on the one hand, and to the active regulatory influence of androgens and estrogens in the late stages of development, on the other hand.
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    Reflex mechanism of maintenance of magnesium homeostasis (1977)
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    Bulletin of experimental biology and medicine 84 (1977), S. 925-928 
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    ISSN: 1573-8221
    Keywords: magnesium ; reflex ; liver ; receptors ; kidney
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Local stimulation of the liver by MgCl2 solution in unanesthetized dogs caused reflex excretion of magnesium through a change in tubular processes. The presence of receptors selectively sensitive to Mg in the liver is postulated. Information from these receptors was shown to spread among the vagus nerves.
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    Antithrombin activity after blockage of the reticuloendothelial system, splenectomy, and partial hepatectomy (1977)
    Springer
    Bulletin of experimental biology and medicine 84 (1977), S. 1249-1251 
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    ISSN: 1573-8221
    Keywords: antithrombins ; reticuloendothelial system ; liver ; spleen
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    Topics: Biology , Medicine
    Notes: Abstract After destruction or removal of part of the liver in rats the levels of antithrombins II, III, and IV fell proportionally to the extent of the interference. Destruction of the spleen led to depression, but splenectomy led to activation of antithrombin IV. Blockade of the reticuloendothelial system caused a smaller decrease in the antithrombin level than partial hepatectomy. It is suggested that the spleen produces an inhibitor of antithrombin IV.
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    Morphological and functional changes in the immune system during reparative regeneration of the liver (1977)
    Springer
    Bulletin of experimental biology and medicine 84 (1977), S. 1491-1495 
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    ISSN: 1573-8221
    Keywords: liver ; regeneration ; immune system ; splenic colonies
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    Topics: Biology , Medicine
    Notes: Abstract During reparative regeneration in the liver functional activity of the immune system is increased. Resection of the liver is accompanied by sharp changes in the structure of the thymus and spleen. The thymus-dependent parts of the spleen are particularly reactive. Resection of the liver in rats is accompanied by an increase in the number of stem cells in the bone marrow, as determined by the splenic colonies method. The number of colony-forming cells in the spleen of recipients of lymphocytes taken from the hepatectomized animals is significantly greater than in the spleen of recipients of lymphocytes from intact rats. If the limb is screened, ability to form endogenous colonies also is increased in partially hepatectomized rats compared with intact animals. Resection of the liver in rabbits is accompanied by a significant increase in immunological reactivity on the first to third days after the operation. The reactions of leukergia and leukocytolysis are sharply intensified during this period.
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    Comparative study of some structural and functional indices of the liver and adrenal cortex in physiologically normal mice of different genetic lines (1978)
    Springer
    Bulletin of experimental biology and medicine 85 (1978), S. 226-229 
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    ISSN: 1573-8221
    Keywords: interlinear differences ; liver ; adrenals ; steroid hormones
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    Notes: Abstract Interlinear differences with respect to morphometric characteristics of the subcellular organization of the hepatocytes and also to indices of adrenocortical function and rate of metabolism of steroid hormones in the liver were found in adult male CBA and C57BL mice. Steroid hormone production by the adrenals and the rate of their metabolism in the liver were found to be inversely proportional in the animals of the two lines. The pattern of structural and functional sponses of the liver of animals of these two strains to pathogenic factors.
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    Electron-microscopic autoradiography of the liver after administration of [3H]corticosterone (1978)
    Springer
    Bulletin of experimental biology and medicine 85 (1978), S. 668-670 
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    Keywords: electron-microscopic autoradiography ; liver ; corticosterone
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    Notes: Abstract Distribution of [3H]corticosterone in the liver cells after adrenalectomy was studied by electron-microscopic autoradiography. The deficiency of endogenous glucocorticoids led to more rapid incorporation of [3H]corticosterone into the liver cells, as shown by the appearance of tracks above the nuclei of the hepatocytes and by an increase in their number above the various cytoplasmic formations.
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    Effect of antihepatocytotoxic serum on DNA synthesis in the rat (1978)
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    Bulletin of experimental biology and medicine 86 (1978), S. 921-924 
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    ISSN: 1573-8221
    Keywords: liver ; antihepatocytotoxic serum ; carbon tetrachloride ; index of labeled nuclei
    Source: Springer Online Journal Archives 1860-2000
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    Notes: Abstract Incorporation of thymidine-3H into parenchymatous and reticulo-endothelial cells of the liver was studied autoradiographically in adult female rats treated with small doses (0.06 μg/100 g body weight per injection) of antihepatocytotoxic serum (AHTS), the γ-globulin isolated from it (γAHTS), and the γ-globulin fraction of normal rabbit serum (γNRS) to intact animals and to rats with liver damage caused by carbon tetrachloride (CCl4). Following injection of γAHTS and, to a lesser degree, of AHTS into intact animals the index of labeled nuclei of both the parenchymatous and the reticulo-endothelial cells was increased. When given after preliminary CCl4 administration, γAHTS stimulated reparative regeneration. The action of γAHTS took place in phases: A period of increase in the index of labeled nuclei was followed by a period of decrease, and this again was followed by a fresh period of stimulation of proliferative processes.
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    Multicomponent system of estrogen-binding proteins in the liver cytosol: Species differences in rats, mice, and guinea pigs (1978)
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    Bulletin of experimental biology and medicine 86 (1978), S. 1096-1099 
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    ISSN: 1573-8221
    Keywords: estrogen-binding proteins ; liver ; species differences
    Source: Springer Online Journal Archives 1860-2000
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    Notes: Abstract Estradiol(E2)-binding proteins of the liver cytosol of sexually mature female and male rats, mice, guinea pigs, and rabbits were investigated by gel-filtration on Sepharose 6B columns. Components with Stokes' radii (a) of 6–7 and 2.5 nm, forming specific, stable complexes with E2, were found in the liver of female rats and of male and female mice. Components with values of (a) of 6–7, 2.5, and under 2.0 nm, specifically binding E2, were discovered in the liver of male rats and male and female guinea pigs. Complexes of E2 with components with (a) values of 6–7 and under 2.0 nm were relatively stable, whereas the complex of E2 with the component witha=2.5 nm could dissociate completely in 45 min. It is suggested that at least some of the components of these heterogeneous populations of E2-binding proteins may participate in the reception of the estrogen signal by the liver.
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    Effect of some extremal factors on the submicroscopic organization of the liver in rats poisoned with carbon tetrachloride (1978)
    Springer
    Bulletin of experimental biology and medicine 86 (1978), S. 1402-1405 
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    ISSN: 1573-8221
    Keywords: electron microscopy ; liver ; carbon tetrachloride ; stress syndrome
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The submicroscopic study of the parenchymatous cells of the liver of rats receiving carbon tetrachlorde (CCl4) in a dose of 0.12 ml/g body weight repeatedly over a period of 25 days was studied. After the end of poisoning the animals were exposed to various extremal stimuli, namely immobilization, sunburn, or a combination of the two. Administration of CCl4, caused the appearance of many lipid inclusions in the cytoplasm of the hepatocytes, the basis for fatty infiltration of the liver. Under the influence of extremal factors, accumulation of lipid material not found and not previously described in any other pathological condition, and evidently reflecting profound disturbances of intracellular metabolism, was discovered in the spaces of the rough cytoplasmic reticulum.
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    Role of specific iodothyronine-binding proteins in nucleo-cytoplasmic relations of thyroid hormones in liver cells (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 17-19 
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    ISSN: 1573-8221
    Keywords: thyroid hormones ; liver ; hormone receptors ; mechanism of action of hormones
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The role of specific iodothyronine-binding proteins of hepatocytes in the nucleo-cytoplasmic relations of thyroid hormones in rats was investigated under normal conditions, after thyroidectomy, and in experimental thyrotoxicosis. The concentration of hormone-binding sites in the cell was shown to depend on the extracellular level of thyroid hormones. The important role of cytosol hormone-binding proteins in the accumulation and intracellular distribution of thyroid hormones is emphasized. Cytosol tri-iodothyronine-binding proteins were shown to play no part in penetration of the hormone into the nucleus. The tri-iodothyronine level in the nuclei was directly dependent on the concentration of receptor proteins in them and the degree of occupancy of the acceptor sites in the receptors themselves.
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    Changes in the distribution of carbonic anhydrase activity in the rat myocardium and liver during acute dichloroethane poisoning (histophotometric investigation) (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 108-110 
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    ISSN: 1573-8221
    Keywords: carbonic anhydrase activity ; dichloroethane ; liver ; myocardium
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    Notes: Abstract Histochemical changes in the distribution of carbonic anhydrase activity in the myocardium and liver of rats were studied after acute oral poisoning with dichloroethane. Kurate's method in Hausler's modification was used. For a semiquantitative assessment of the changes in enzyme activity a histophotometric method was used. A definite increase in carbonic anhydrase activity in the myocardium and liver was observed in most of the experimental animals and the index of correlation between these changes remained the same as in the intact rats.
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    URL: http://dx.doi.org/10.1007/BF00802821
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  • 68
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    Electronic Resource
    Effect of glucocorticoids on α-fetoprotein synthesis and liver structure of mice with acute carbon tetrachloride poisoning (1977)
    Springer
    Bulletin of experimental biology and medicine 83 (1977), S. 146-148 
    Details
    ISSN: 1573-8221
    Keywords: glucocorticoids ; α-fetoprotein ; liver ; carbon tetrachloride
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Experiments on male C57BL mice showed that inhalation of CCl4 for 15 min in a concentration of 0.05 ml/4 liters air causes severe degenerative changes in the liver with features of necrobiosis. However, phenomena of regeneration and cell infiltration arise as early as after 24 h and are accompanied by the secretion of α-fetoprotein into the blood stream. After 4 days the foci of necrobiosis disappear and are totally replaced by lymphocytes with large hepatocytes at the periphery. Processes of regeneration in animals receiving hydrocortisone (20 mg/kg) or dexamethasone (2 mg/kg) therapeutically or prophylactically were less marked and the number of animals producing α-fetoprotein was reduced from 92 to 60–65%.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799405
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  • 69
    Electronic Resource
    Electronic Resource
    Activity of lysosomal enzymes in drug-induced liver damage (1989)
    Springer
    Bulletin of experimental biology and medicine 108 (1989), S. 1439-1441 
    Details
    ISSN: 1573-8221
    Keywords: liver ; drugs ; lysosomal enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00841727
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  • 70
    Electronic Resource
    Electronic Resource
    Effect of venous pressure on hepatic microcirculation and lymph flow (1989)
    Springer
    Bulletin of experimental biology and medicine 108 (1989), S. 1057-1058 
    Details
    ISSN: 1573-8221
    Keywords: microcirculation ; lymph flow ; venous pressure ; liver ; perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00840632
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  • 71
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    Electronic Resource
    Mitochondrial ultrastructure and succinate dehydrogenase activity in hepatocytes during cholestasis (1989)
    Springer
    Bulletin of experimental biology and medicine 108 (1989), S. 1354-1358 
    Details
    ISSN: 1573-8221
    Keywords: liver ; obstructive jaundice ; structure and electron cytochemistry of hepatocytemitochondria
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00839489
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