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  • Articles  (13)
  • liver  (13)
  • Springer  (13)
  • 2000-2004
  • 1995-1999
  • 1980-1984
  • 1975-1979  (13)
  • 1976  (13)
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  • Articles  (13)
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Keywords
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  • Springer  (13)
Years
  • 2000-2004
  • 1995-1999
  • 1980-1984
  • 1975-1979  (13)
Year
Topic
  • 1
    Electronic Resource
    Electronic Resource
    Chemiluminescence of mouse liver after administration of a carcinogen (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1556-1557 
    Details
    ISSN: 1573-8221
    Keywords: liver ; chemiluminescence ; carcinogens
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Changes in the intensity of chemiluminescence of the liver were observed at different times after injection of 9,10-dimethyl-1,2-benzanthracene into mice. The possible connection between the observed phenomena and the formation and accumulation of the endogenous carcinogen in the liver is examined.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799810
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  • 2
    Electronic Resource
    Electronic Resource
    Changes in the structure of chromatin in hepatocyte nuclei of rats adapted to hypoxia (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 445-448 
    Details
    ISSN: 1573-8221
    Keywords: hypoxia ; liver ; structure of hepatocyte chromatin ; Acridine Orange ; microfluorometry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The structure of chromatin in the nuclei of isolated surviving hepatocytes and of isolated hepatocyte nuclei was studied by fluorochroming with Acridine Orange and microfluorometry of the luminescence of chromatin-bound dye at 530 and 590 nm in intact rats and rats adapted to hypoxia in a pressure chamber for 60 days. Hepatocyte nuclei of intact rats were shown to be distributed on the basis of their fluorescence at 530 nm into three classes, with a ratio between intensities of 1∶2∶4, whereas hepatocyte nuclei of rats adapted to hypoxia formed only one class, corresponding to the second class in the control. The ratio between the intensities of luminescence at 590 nm and 530 nm (the coefficient α) forms a normal distribution in intact rats, but in adapted rats it formed a bimodal distribution with a shaft of the maxima toward both sides of the control. During hypoxia repression of some genes and depression of others is considered to take place in the chromatin of liver nuclei.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00804945
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  • 3
    Electronic Resource
    Electronic Resource
    Effect of carbon tetrachloride on RNA metabolism in the rat liver (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 677-680 
    Details
    ISSN: 1573-8221
    Keywords: carbon tetrachloride ; liver ; total, nuclear, and cytoplasmic RNA ; RNA turnover
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of systematic administration of carbon tetrachloride (CCl4) to rats on the RNA content in the liver and the intensity of incorporation of the labeled precursor (uridine-H3) into it was investigated. Comparison of the results of morphological and biochemical studies revealed two consecutive stages of the toxic process, terminating in the formation of septal fibrosis. The sharpest changes in rapid RNA turnover in the rat liver were observed during the first 3 months of action of the toxic agent. The disturbance of metabolism also was reflected in a lowered RNA level and changes in the nucleo-cytoplasmic ratio in the tissue of the affected liver.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797127
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  • 4
    Electronic Resource
    Electronic Resource
    Effect of disturbance of the innervation of the liver and loss of bile on biliary and hepatic enzyme activity (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 847-849 
    Details
    ISSN: 1573-8221
    Keywords: enzymes ; liver ; disturbance of innervation ; loss of bile
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Continuous loss of bile from rats with a bile reservoir connected to the common bile duct led to an increase in specific activity of malate, lactate, glutamate, and glucose-6-phosphate dehydrogenases, alkaline and acid phosphatases, urokinase, and histidase in liver homogenates by the seventh day. By the tenth day their specific activity had fallen. After disturbance of the innervation of the rats' livers the ATP concentration fell sharply and the specific activity of the above-mentioned enzymes in the liver was considerably inhibited. During continuous loss of bile, fluctuating changes took place in the specific activity of these enzymes and also of sorbitol dehydrogenase in the bile, starting from the first and continuing until the tenth day of the experiment. Support for the view that these fluctuations were under the control of the nervous system was given by the considerable changes in their character following disturbance of the hepatic innervation.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00802999
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  • 5
    Electronic Resource
    Electronic Resource
    Content of adenyl mononucleotides and respiratory phosphorylation in mitochondria of rats with transplantable tumors (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 903-905 
    Details
    ISSN: 1573-8221
    Keywords: tumor growth ; oxidative phosphorylation ; ATPase ; adenyl mononucleotides ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The content of adenyl mononucleotides, the process of oxidative phosphorylation, and the ATPase activity of the liver mitochondria of rats with transplantable sarcoma 45 and Walker's carcinosarcoma were investigated at different stages of tumor growth. The fall in the ATP level observed in the liver mitochondria of the rats with tumors was due, first, to inhibition of its formation as a result of the partial uncoupling of oxidative phosphorylation and, second, to an increased rate of its breakdown as a result of increased ATPase activity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00803019
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of contrycal on activity of dehydrogenases and their isozymes in muscles and organs of animals with developing granulation tissue (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1001-1003 
    Details
    ISSN: 1573-8221
    Keywords: lactate dehydrogenase ; malate dehydrogenase ; isozymes ; protease inhibitor, contrycal ; muscles ; liver ; kidneys ; heart
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of contrycal on the state of the enzyme systems of the muscles, liver, kidneys, and heart was investigated in rats with developing granulation tissue. This protease inhibitor was found to stimulated lactate and malate dehydrogenase activity and also the isozyme spectrum of these enzymes. The action of the inhibitor was manifested as a change in the state of the enzyme systems both at the site of injury (granulations and underlying tissue) and in certain internal organs (liver and kidneys).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789852
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of bilateral subdiaphragmatic vagotomy on the activity of some enzymes of energy metabolism in the liver (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1010-1011 
    Details
    ISSN: 1573-8221
    Keywords: vagotomy ; liver ; enzymes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Bilateral subdiaphragmatic vagotomy leads to a marked decrease in hexokinase, glucokinase, glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase and lactate dehydrogenase activity in the soluble fraction of rat liver. The blood sugar level was unchanged at all times after the operation. These changes in enzyme activity evidently take place on account of the absence of parasympathetic impulses to the liver cell.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789855
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  • 8
    Electronic Resource
    Electronic Resource
    Bile secretory function of the liver in birds of different ages with experimental atherosclerosis (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1298-1301 
    Details
    ISSN: 1573-8221
    Keywords: experimental atherosclerosis ; age ; bile acids ; cholesterol ; liver
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The bile-secretory function of the liver under normal conditions and in experimental atherosclerosis produced by administration of cholesterol was studied in experiments on young (3–4 months old) and adult (30–36 months old) hens of the Russian White breed. During natural aging a decrease in the total and free cholesterol concentrations in the blood serum and in the bile-secretory function of the liver was observed These indices were raised during administration of cholesterol and atherosclerotic changes developed in the aorta. The severity of these changes compared with normal was greater in the adult than in the young experimental birds.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799454
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  • 9
    Electronic Resource
    Electronic Resource
    Diurnal changes in the number of mitoses and of DNA-synthesizing cells in tissues of young rats (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1712-1714 
    Details
    ISSN: 1573-8221
    Keywords: Mitotic index (MI) ; index of labeled nuclei (ILN) ; diurnal changes in MI and ILN ; liver ; epidermis ; pancreas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Regular diurnal changes in the number of mitoses (MI) and the number of DNA-synthesizing cells (ILN) were demonstrated in the liver, epidermis, and exogenous part of the pancreas of rats aged 7 days. The character of these changes differed in the various tissues. No regular correlation was found between diurnal changes in MI or ILN.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00790395
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  • 10
    Electronic Resource
    Electronic Resource
    An expanded model of bilirubin kinetics: Effect of feeding, fasting, and phenobarbital in Gilbert's syndrome (1976)
    Springer
    Journal of pharmacokinetics and pharmacodynamics 4 (1976), S. 115-155 
    Details
    ISSN: 1573-8744
    Keywords: bilirubin kinetics ; Gilbert's syndrome ; compartmentation ; liver ; heme ; multicompartmental model ; 14C-bilirubin ; 3H-bilirubin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract In a patient with classical Gilbert's syndrome, tracer 14C-bilirubin was infused intravenously at constant rate for 20–32 hr. Total bilirubin production (TBrP) and bilirubin production as estimated from plasma data only (PBrP) were calculated from the specific activity of bilirubin in hepatic bile and in plasma. Pulse labeling with 3 H -δ-aminolevulinic acid permitted estimation of bilirubin fractions synthesized in the liver and excreted directly into bile or returned to plasma. Neither fasting nor phenobarbital (PB) affected TBrP or PBrP; the rise in plasma bilirubin on fasting and fall on PB were entirely accounted for by changes in hepatic pigment clearance. A multicompartmental model, formulated to fit the data obtained in all three experimental conditions, suggested that bilirubin produced in hepatocytes is characterized by three discrete, noncommunicating compartments which differ kinetically and in the manner of pigment transport into plasma, bile, or both. The size and kinetics of each hepatic compartment resembled those of known hepatic heme or hemoprotein fractions. Transfer of bilirubin from plasma to bile occurs by separate hepatic channels which do not communicate in the liver with compartments of endogenously formed pigment. Fasting and PB produced minor modifications in mass and turnover of individual hepatic compartments but did not significantly alter the total rate of bilirubin synthesized in the liver and delivered either to plasma or directly into bile. These findings suggest that production and transport of bilirubin in the liver are highly compartmentized processes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01086150
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  • 11
    Electronic Resource
    Electronic Resource
    Effect of parenteral administration of exogenous cytochrome c on cytochrome content in the liver of rabbits with chronic carbon tetrachloride poisoning (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1516-1517 
    Details
    ISSN: 1573-8221
    Keywords: carbon tetrachloride ; liver ; cytochrome c
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Administration of exogenous cytochrome c to rabbits with chronic poisoning prevented the decrease in the content of cytochrome c in homogenates and of cytochromesa+a 3, b, and c+c1 in the mitochondria of the liver and promoted restoration of the normal histological structure of the organ.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799796
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  • 12
    Electronic Resource
    Electronic Resource
    Assimilatory and excretory function of the isolated perfused dog liver (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 489-491 
    Details
    ISSN: 1573-8221
    Keywords: liver ; liver functions ; bromsulfthalein method ; perfusion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract In experiments on dogs the assimilatory-excretory function of the liver was studied by means of the bromsulfthalein method in the intact animal and during perfusion of the isolated organ through the portal vein by means of an artificial circulation apparatus. Under perfusion conditions the rate of uptake of the dye was 50–60% of the value of this index in the intact animal. The rate of elimination of bromsulfthalein with the bile and the biliary plasma clearance in the intact animal were five to six times higher. The main cause of the reduction in the assimilatory-excretory function of the isolated liver is evidently hypoxia developing after denervation and removal of the organ from the body, and also during extracorporeal perfusion itself.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797546
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  • 13
    Electronic Resource
    Electronic Resource
    Content and biosynthesis of ubiquinone-9 in the liversof albino rats adapted to altitude hypoxia (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 185-186 
    Details
    ISSN: 1573-8221
    Keywords: ubiquinone-9 ; altitude hypoxia ; liver ; adaptation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The content and biosynthesis of ubiquinone-9 were studied in thin liver slices from rats adapted to altitude hypoxia. A more than threefold increase in ubiquinone-9 biosynthesis was found in the initial period of adaptation to altitude hypoxia, but this increase 2 weeks after the beginning of adaptation was very slight. The content of ubiquinone-9 in the rat liver showed no significant change during adaptation to altitude hypoxia for 1 month.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801064
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