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  • bone marrow  (13)
  • Springer  (13)
  • 2020-2023
  • 1980-1984
  • 1975-1979  (13)
  • 1935-1939
  • 1976  (13)
Collection
Keywords
Publisher
  • Springer  (13)
Years
  • 2020-2023
  • 1980-1984
  • 1975-1979  (13)
  • 1935-1939
Year
  • 1
    Electronic Resource
    Electronic Resource
    Cloning of canine hematopoietic cells in vitro (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 588-591 
    Details
    ISSN: 1573-8221
    Keywords: precursors of granulocytes and macrophages ; bone marrow ; colony-stimulating factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Culture of canine hematopoietic cells in agar by a method enabling the number of committed precursor cells of granulocytopoiesis and of humoral factors causing their proliferation to be determined, is described. Canine serum in a concentration of 20% was used as the source of colony-stimulating activity. A linear relationship was established between the number of explanted cells and the number of colonies developing within the range of 0.25·105 and 8·105 cells/ml.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797577
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  • 2
    Electronic Resource
    Electronic Resource
    Proliferation and differentiation of hematopoietic stem cells During hypokinesia (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 630-632 
    Details
    ISSN: 1573-8221
    Keywords: hematopoietic stem cells ; hypokinesia ; bone marrow ; spleen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Expgenous cloning of hematopoietic stem cells of bone marrow and spleen in the femur and spleen of recipient mice showed that during hypokinesia the kinetics of the stem cell population differs in the two organs (spleen and bone marrow). The character of differentiation of the transplantation stem cells from the different sources was undisturbed in the recipients' spleen. Bone marrow stem cells, settling in the femur, changed their character of differentiation toward an increase in erythropoietic function, whereas the direction of differentiation of the splenic stem cells was unchanged.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797589
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  • 3
    Electronic Resource
    Electronic Resource
    Diurnal rhythm of mitotic activity, DNA synthesis, and duration of mitoses in mouse bone marrow cells (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 741-743 
    Details
    ISSN: 1573-8221
    Keywords: mitotic index ; DNA synthesis ; diurnal rhythm ; bone marrow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Cells of the myeloid and erythroid series of mouse bone marrow are characterized by a well-defined diurnal rhythm of mitotic activity and of DNA synthesis, with coincidence between the times of maxima of the number of mitoses and of DNA-synthesizing cells (in the afternoon and night) and of their minima (in the morning and evening). The increase in mitotic activity is connected with the entry of large numbers of cells into mitosis and not with an increase in the duration of mitosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00797150
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  • 4
    Electronic Resource
    Electronic Resource
    Changes in the number of stem cells during cultivation of mouse bone marrow on a bed of fibroblast-like cells (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 892-894 
    Details
    ISSN: 1573-8221
    Keywords: bone marrow ; hematopoietic stem cell ; tissue culture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The number of colonies was counted in the spleen of irradiated mice after injection of a culture of mouse bone marrow cells. The colony-forming units were found to persist in the culture only for a short time. The use of a previously grown bed of fibroblasts of bone-marrow origin did not affect the preservation of the colony-forming units or the dynamics of the change in their number.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00803014
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  • 5
    Electronic Resource
    Electronic Resource
    Distribution of colony-forming cells in the bone marrow and spleen of irradiated mice (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1028-1030 
    Details
    ISSN: 1573-8221
    Keywords: fractionf ; bone marrow ; spleen ; stem cells
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Two hours after transplantation of 2×105 bone marrow cells, 1.7–2.8% and 14–16% of colonyforming units (CFU) were retained respectively in the femoral bone marrow and spleen of the recipients. After 24 h, 1–2% and 21–26% of CFU respectively remained in these organs. If 2.5×106–1.7×107 bone marrow cells were transplanted, the fractionf in the bone marrow and spleen of the recipients (under saturation conditions) was unchanged during the 24-h period. The value for CFU settling in the spleen was 20–22%, whereas for CFU settling in the femoral marrow the value off was 2.4–2.7%. It is postulated that the same number of CFU settles in the whole volume of the bone marrow as in the whole spleen. The total number of CFU settling in the spleen and in the whole volume of the bone marrow averages 40–50%. The fate of the remaining CFU is unknown.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00789861
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  • 6
    Electronic Resource
    Electronic Resource
    Effect of exogenous DNA on content and biosynthesis of endogenous DNA in rat bone marrow (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1186-1187 
    Details
    ISSN: 1573-8221
    Keywords: Exogenous DNA ; bone marrow ; rate of DNA biosynthesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The effect of exogenous DNA on the content and rate of biosynthesis of endogenous DNA in rat bone marrow was studied. After injection of high-polymer homologous DNA into intact rats the endogenous DNA content per gram bone marrow was found to be reduced for the first 3 days (the decrease was most marked after 3 days, namely by 36%) and it returned to normal by the 6th day. The rate of DNA biosynthesis in rat bone marrow was increased after 18 h (when it was twice as high as in the control) and after 6 days (by 58%), and it was close to normal again 1–3 days after injection of DNA.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00785551
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  • 7
    Electronic Resource
    Electronic Resource
    Suppression of interferon synthesis during the graft versus host reaction in (CBA×C57BL/6) F1 mice (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1375-1377 
    Details
    ISSN: 1573-8221
    Keywords: graft versus host reaction ; bone marrow ; interferon
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract During the development of the graft versus host reaction (GVHR) in (CBA×C57BL/6) F1 mice after transplantation of spleen cells from mice of the parental C57BL/6 strain, production of serum interferon induced by intraperitoneal injection of Newcastle disease virus was sharply reduced. Interferon production was reduced and later completely abolished in cultures of bone marrow cells from mice during development of the GVHR. This phenomenon can serve as a criterion of the development of the GVHR.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00799481
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  • 8
    Electronic Resource
    Electronic Resource
    Isolation of cells most actively synthesizing DNA from hematopoietic organs by fractionation in an albumin density gradient (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1673-1676 
    Details
    ISSN: 1573-8221
    Keywords: DNA biosynthesis ; DNA-dependent DNA-polymerase ; aspartate-carbamoyl transferase ; bone marrow ; spleen ; fractionation ; bovine serum albumin gradient
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Fractionation of suspensions of rat bone marrow or spleen cells yielded fractions in which activity of DNA-dependent DNA-polymerase and aspartate-carbamoyl transferase and incorporation of14C-thymidine were two or three times greater than in the initial suspension. Depending on the osmotic concentration of the original 35% solution of bovine serum albumin, the cells synthesizing DNA most actively were concentrated in fractions Nos. 5–6 (370 milliosmoles) or Nos. 2–3 (380 milliosmoles).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00790382
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  • 9
    Electronic Resource
    Electronic Resource
    Proliferative activity of clonogenic bone marrow stromal precursor cells (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 67-69 
    Details
    ISSN: 1573-8221
    Keywords: bone marrow ; monolayer culture ; proliferation ; stromal precursors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The proliferative activity of precursors of bone marrow stromal cells forming colonies (clones of fibroblasts) in monolayer cultures was studied by the thymidine-suicide method in vitro. Clonogenic cells of native bone marrow were shown not to be inhibited by thymidine-H3 with high specific activity, i.e., they virtually do not proliferate in vivo. Having started to proliferate 24 h after explantation, they then give rise to colonies of fibroblasts. In 6–14-day bone marrow cultures 39±4% of clonogenic cells die under the influence of thymidine-H3. Hence it follows that, unlike precursor cells in native bone marrow, clonogenic cells in primary cultures proliferate actively.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800170
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  • 10
    Electronic Resource
    Electronic Resource
    Effect of mechanical injury to bone marrow in irradiated mice on dispersion of endogenous colony-forming units (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 88-89 
    Details
    ISSN: 1573-8221
    Keywords: mice ; irradiation ; bone marrow ; colony-forming units
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The femur was fractured in mice irradiated in a dose of 600 R and the fragments united by a metal pin. Under these conditions, when part of the bone marrow was destroyed, the number of endogenous colonies in the spleen was increased.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800177
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  • 11
    Electronic Resource
    Electronic Resource
    Radiosensitivity and direction of differentiation of colony-forming cells in the spleen (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 92-94 
    Details
    ISSN: 1573-8221
    Keywords: spleen ; bone marrow ; colony-forming units ; radiosensitivity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The radiosensitivity of splenic colony-forming units (CFUs) settling in the bone marrow and spleen does not differ significantly. The value of D0 for CFUs forming colonies in the spleen varies between 105 and 120 R. D0 for CFUs forming colonies in bone marrow is 120–135 R. It is postulated that two fractions for CFUs are represented in bone marrow, one radiosensitive, the other radioresistant. In the spleen mainly the radiosensitive fraction of CFUs is found.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00800179
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  • 12
    Electronic Resource
    Electronic Resource
    Relations between hematopoiesis and osteogenesis in some species of rodents (1976)
    Springer
    Bulletin of experimental biology and medicine 81 (1976), S. 259-261 
    Details
    ISSN: 1573-8221
    Keywords: bone marrow ; extramedullary transplantation ; xenogeneic grafts ; osteogenesis ; hematopoiesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Different relations between hematopoiesis and osteogenesis were observed in bone marrow grafts from rats, guinea pigs, and striped hairy-footed hamsters, transplanted beneath the renal capsule of irradiated mice. Active osteogenesis took place in grafts from rats and guinea pigs whereas hematopoiesis was observed irregularly (rats) or it ceased to occur (guinea pigs). In grafts from the hamsters, on the other hand, intensive hematopoiesis was maintained but the osteogenic properties of the stroma were weak. In some species the presence of bone tissue is considered to be not strictly essential for the normal maintenance of myeloid hematopoiesis whereas in others the initial development of a bony stroma is an essential condition for subsequent functioning of the hematopoietic tissue.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00801090
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  • 13
    Electronic Resource
    Electronic Resource
    Use of autologous bone marrow taken from a shielded area at various times after irradiation (1976)
    Springer
    Bulletin of experimental biology and medicine 82 (1976), S. 1855-1857 
    Details
    ISSN: 1573-8221
    Keywords: irradiation ; shielding ; autografting ; bone marrow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract Shielding the leg saves the life of 32% of animals irradiated with x rays in an absolutely lethal dose (850 R). Autografting of bone marrow from the protected area, if carried out immediately after irradiation, greatly increases the shielding effect. This protective action on autografting continues if it is carried out during the first 5 days after irradiation. Later (on the 7th to 10 th day after irradiation) autografting of bone marrow from the shielded area becomes less effective.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00785718
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