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  • Articles  (79)
  • Chemistry  (79)
  • Wiley-Blackwell  (79)
  • Elsevier
  • Springer Nature
  • 1980-1984
  • 1975-1979
  • 1970-1974  (79)
  • 1973  (79)
  • Technology  (79)
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  • Articles  (79)
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  • Wiley-Blackwell  (79)
  • Elsevier
  • Springer Nature
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  • 1980-1984
  • 1975-1979
  • 1970-1974  (79)
Year
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  • 1
    Electronic Resource
    Electronic Resource
    Transport through crosslinked poly(2-hydroxyethyl methacrylate) hydrogel membranes (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 353-367 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The transport of urea and other biologically interesting solutes in aqueous solution across poly(2-hydroxyethyl methacrylate) (p-HEMA) hydrogel membranes has been studied. The results show that p-HEMA membranes have a high permeability to urea due to a strong interaction between the polymer and urea, and, in addition, they are consistent with a pore flow model in which solute transport takes place through water-filled regions essentially unaffected by the surrounding polymer matrix. The results indicate that such p-HEMA membranes might be suitable for hemodialysis applications.
    Additional Material: 4 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070407
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  • 2
    Electronic Resource
    Electronic Resource
    Analyses of a silicone elastomer heart ball valve (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 405-418 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: This work represents a preliminary study of one case history of a silicone heart valve. The laboratory techniques employed have proven useful in characterizing the polymer before and after implantation. Before any model explaining ball variance can be proposed it must be determined whether the polymer loses its integrity because specific constituents in the body fluids interact with primary valence bonds in the polymer chains, or if the fluids simply cause swelling and plasticization of the crosslinked system and the damage is the result of mechanical work on the weaker polymer system. Detailed kinetic and thermodynamic studies are underway to answer these questions.The work summarized in this paper refers to the evaluation of only one specimen and should not be taken to mean that every silicone ball from a heart valve prosthesis will show this variance. The incidence of functionally variant silicone balls as reported to one manufacturer represents approximately 1.5% of the aortic and less than 0.05% of the mitral prostheses which have been supplied by this manufacturer. A small percent of valves of this type have the potential of becoming functionally variant and this is one failure mode which should be considered in the implantation of silicone ball valves.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070504
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  • 3
    Electronic Resource
    Electronic Resource
    Preparation of dental alloy by splat cooling (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 481-484 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Splat cooling has been used for the preparation of dental alloy in the form of ribbons of 5-25 μm in thickness. The powdered alloy was produced by shaking the ribbons with a dental pestle in a mechanical amalgamator. One minute shaking produced a powder all of which passed a standard 400 mesh sieve. Only phases expected at room temperature have been produced thus far.
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070509
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  • 4
    Electronic Resource
    Electronic Resource
    Masthead (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973) 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070601
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  • 5
    Electronic Resource
    Electronic Resource
    Intravascular radiopaque catheters in the dog: Tissue reaction and possible lead lossThis represents part of the work done for the thesis requirement for a M.A. degree from the Department of Anatomy and Physiology, Indiana University (Bloomington). (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 167-178 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Male mongrel dogs were divided into two groups and placed in urine collection cages for 24-hr urine samples. One group was implanted with sterile radiopaque polyethylene catheter and stainless steel guide wire fragments in the venous vasculature via an incision in the left femoral vein and the remaining group in the arterial vasculature via the left femoral artery. The catheter fragments, made radiopaque by an admixture of 25% lead oxide and 75% polyethylene, were located by roentgenograms and along with the guide wire fragments removed at necropsy 18-46 weeks following implantation. Gross and microscopic tissue lesions consisted of fibrous tissue tubes and slings which completely enclosed and anchored the fragments and intimal hyperplasia with fibrous tissue organization of thrombi, respectively. Tissue staining techniques for lead, catheter fragment weights, blood lead levels, and urine lead content all revealed no evidence of lead loss from the catheter fragment implants.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070205
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  • 6
    Electronic Resource
    Electronic Resource
    Diffusion of pyrimethamine from silicone rubber and flexible epoxy drug capsules (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 193-200 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The rate of diffusion of pyrimethamine, a pyrimidine-based antimalarial drug, from silicone rubber is compared to the diffusion of this drug from a flexible epoxy. Specific amounts of drug were mixed into the epoxy resin prior to the addition of an aliphatic diamine curing agent in the reparation of the epoxy-drug capsules and into the silicone rubber prior to vulcanization with stannous octoate in the preparation of silicone drug capsules. These capsules, in the form of discs, were separately immersed in water which was replenished at regular time intervals. The amount of drug released was determined spectrophotometrically (λ max = 275 mμ). Silicone rubber discs with 20 mg of drug incorporated/disc showed a much higher initial release rate than epoxy discs with an equivalent amount of drug incorporated. The rate of drug release is shown to be a nonlinear function of the amount of drug initially incorporated. The amine functional groups on pyrimethamine, and the possibility of its participation in the curing of the epoxy is noted. In silicone rubber, such interaction is not expected. The addition of a silica filler to the epoxy drug mixture is associated with greater uniformity in the observed drug release rates of capsules made from the same batch of polymer drug mixture. The Shore A durometer hardness of these drug capsules are 30 and 70 for silicone rubber and epoxy, respectively.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070207
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  • 7
    Electronic Resource
    Electronic Resource
    Studies on the skeletal attachment of experimental hip prostheses in the pygmy goat and the dogThis project was supported in part by the Educational Fund, Department of Surgery, William Beaumont Hospital, Royal Oak, Michigan and by the Pontiac Medical Sciences Laboratories, Pontiac, Michigan. (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 187-193 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Significant hazards to the use of femoral head prostheses-infection, corrosion, fatigue failure, interface motion, latent failure-dictate new standards for new prosthesis models. This study investigates ceramic-coated metal hip prostheses which have the theoretical advantage of tissue ingrowth. In long-term analysis, ingrowth did not occur in this study in the pygmy goat. Sintered metal prosteses were inserted in two dogs with bilateral congenital hip dysplasia. Excellent clinical results were obtained with radiologic evidence of bone envelopment of the sintered metal. Based on previous applications of silicone rubber to weight bearing by the author, the advantages of a silicone rubber prosthesis or silicone rubber-covered prosthesis are tissue compatibility, new bone formation, peak stress dispersal, and simulation of normal articular cartilage. A silicone rubber prosthesis was fabricated for the pygmy goat. It was inserted and initially has given good clinical results.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070312
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  • 8
    Electronic Resource
    Electronic Resource
    The anchor oral endosteal implant (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 235-249 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Since the accidental rediscovery of the endosteal implant by Formaggini in the late 1940's, the field has witnessed a tremendous evolution in theory and clinical application. Chercheve, in his efforts to improve on earlier spiral designs, proposed several theories on the relationship of the metallic endosteal implant to its osseous environment. Some of the problems he experienced still have not been overcome in our present designs.The development of the blade implant marked a true advancement in endosteal design. This implant proved to be much more functional and reliable than the spiral concept; however, it too had certain disadvantages which became obvious after a relatively short period of clinical trial. The anchor endosteal implant was developed as a result of efforts to correct the various problems associated with the blade.Preliminary animal research using both anchor and blade implants was begun. Four dogs had each type of implant inserted in edentulous areas. The animals were sacrificed four months post insertion for histologic examination. More sophisticated animal implant studies are being performed at the Brookdale Hospital Medical Center.Clinical evaluation of the anchor implant over a 3-year period has been very encouraging. Results have indicated a higher level of clinical success than previously achieved with blade or spiral designs.
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070316
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  • 9
    Electronic Resource
    Electronic Resource
    The fracture mechanics of bone - another look at composite modeling (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 383-399 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: The energy absorbed in the impact fracture of bovine metatarsal and metacarpal bone was shown to depend on the aspect from which the inpact specimen was obtained. In a majority of cases caudad specimens were more than an order of magnitude tougher than cephalad specimens and the fracture surfaces of the tough specimens were fibrous or woody in appearance due to osteon pull out. This pull out phenomenon was identified as a major factor in determining the toughness of bone and is analogous to the toughening effect produced by fiber pull out in synthetic composites. Whenever a substantial component of the applied stress was resolved across the osteons, the fracture cracks were seen to propagate in an interosteonal mode similar to the delamination of synthetic composites with weak interfaces. Plastic deformation of the matrix is the third mechanism commonly employed to effect toughening in synthetic composites. Although no similar phenomenon was demonstrated in this study, it is probable that this also makes some contribution to the work-to-fracture of bone.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070324
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  • 10
    Electronic Resource
    Electronic Resource
    Announcement (1973)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 7 (1973), S. 273-273 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820070402
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