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  • hypertension  (29)
  • 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
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  • 1
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    A Glimpse into the Seismicity of the Ionian Islands between 1658 and 1664 (2008)
    Springer
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Mostly based on traditional catalogues, without further research, several modern parametric catalogues are nevertheless straightforward, without question marks, and easily misleading (chronology, epicentre, epicentral intensity, not to speak of magnitude). The example of an Ionian time-window (1658-1664), with several major events, shows that the historical seismicity of the Ionian Islands, often thought to be well-known, actually needs a more or less drastic revision. A wealth of sources was collected, mostly from the Archives of the Republic of Venice, then ruling the main three islands of the Ionian Archipelago; it was ascertained that there are no important chronological gaps in the surviving documentation. Similarly outstanding, and in fact at the basis of a more balanced and precise view of one of the events in this time-window, are the souvenirs of Christoff von Degenfeld, a German nobleman at the service of the Republic of Venice. His manuscript, discovered at the library of Karlsruhe (Germany) in 1992, has been consulted again in the original, on the occasion of the preparation of this paper. Some question marks remain on the distributions of macroseismic effects of the earthquakes within this time-window, and this is due to the lack of information concerning the mainland. For this reason this study does not propose epicentres and, of course, magnitudes. An unusually long documentary appendix is provided, with the hope that it might contribute in discouraging authors of parametric earthquake catalogues from hasty exploitation and interpretation of often unreliable current catalogues.
    Beschreibung: Published
    Beschreibung: 43-91
    Beschreibung: 3.10. Sismologia storica e archeosismologia
    Beschreibung: open
    Schlagwort(e): Historical seismology ; Ionian Islands 1658-1664 ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 2
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    Evidence of seismic deformation of the paved floor of the decumanus at Tindari (NE, Sicily) (2008)
    Blackwell Publishing Ltd
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Most of the ancient town of Tindari (NE, Sicily) was settled on a plateau the most surficial layer of which was made of unconsolidated material. Ongoing excavations at the archaeological site at Tindari uncovered a large portion of the decumanus which suffered deformations preliminarily assigned to coseismic effects. An analysis of the local dynamic response through the simulation of strong seismic shaking to the bedrock and modelling of spectral ratios of the bedrock-soft soil was carried out to verify the susceptibility of superficial terrains of the promontory to coseismic deformations. To perform this simulation the finite element method (FEM) was used. Four accelerometric recordings of three earthquakes of medium-high magnitude, recorded on rocky sites, were chosen to simulate the seismic shaking, using a constitutive law for the materials composing the promontory layers both of linear-elastic type and of elastoplastic type. The analysis of the linear-elastic field allowed the definition of the frequencies for which the spectral ratios of the accelerations recorded the highest amplifications; in particular the frequency range 31.5–37.2 Hz can be combined with deformation of the paved floor of the decumanus. The analysis in the elastoplastic field highlighted the zones of promontory more susceptible to suffer plasticization process. The results show that the topmost layer of the decumanus is the most susceptible to suffer plasticization. Therefore, the performed analysis lends greater support to the hypothesis that the deformations were produced by seismic shaking.
    Beschreibung: Published
    Beschreibung: 213-222
    Beschreibung: 3.10. Sismologia storica e archeosismologia
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Fourier analysis ; Elasticity and anelasticity ; Earthquake ground motions ; Site effects ; Computational seismology ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 3
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    Jean Vogt 1929-2005. His Life as a Seismologist, Geologist, Geographer, and Historian (2008)
    Springer
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: Jean Vogt was born in 1929 in Strasbourg (France), where he attended primary and secondary school. At the University of Strasbourg, he graduated in Geography, and majored in Geomorphology. His professor was the geographer Jean Tricart, who taught him the importance of both geological field work and archive investigation. In 1955 he joined the French West-Africa Geological Service and later the French Bureau for Geology and Mines (BRGM). Along the following 20 years he lived as a “geological” globetrotter in a number of countries, dispensing his time between the field and the archives. In these years, he was concerned mainly with mining geology, geomorphology, superficial deposits, and landslides. This unique experience led him in 1975 to the responsibility of the “Seismo-Tectonic Project”, the BRGM project in relation with the French nuclear power programme. From 1975 to 1984, he gave a substantial impulse to the study of French historical earthquakes, and since then he visited almost every public archive in France, and several major archives and libraries in Europe and abroad. He took care at the same time of the follow-up of macroseismic studies of present-day earthquakes. After he retired in 1984, he continued on a personal basis his investigations of historical earthquakes, in Europe, the Middle East, North Africa, and the Caribbean area. Alongside and for about 50 years, Jean Vogt investigated uninterruptedly the agrarian history of Northeastern France and Southwestern Germany. He published in scientific journals and in local learned societies bulletins more than 500 notes and articles devoted to a variety of subjects, such as soil erosion, agriculture, cattle trade, and social conflicts. Jean Vogt died on 5 June 2005 in Strasbourg. His scientific legacy consists of a wealth of published papers, manuscripts, documentation related to history and seismology, awaiting to be further exploited, as he would have done.
    Beschreibung: Published
    Beschreibung: 3-16
    Beschreibung: 3.10. Sismologia storica e archeosismologia
    Beschreibung: reserved
    Schlagwort(e): Jean Vogt ; biography ; historical seismology ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 4
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    Strong Earthquakes in North-Western Africa in the Second Half of the 17th Century, AD: A Critical Reappraisal of the Historical Evidence (2008)
    Springer
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: The recent seismological literature recorded three strong earthquakes in Algeria, Libya and Tunisia between 1656 and 1694 AD. The historical evidence for these derives from European sources only (gazettes, journalistic pamphlets, missionary literature). Considering the kind of sources involved, their likely biases and the geographical distances that divided their places of production from the places that they spoke about, it is possible that some of these accounts could be less than reliable, and therefore have little use as materials from which to assess earthquake parameters. To answer these doubts, we have retrieved, cross-checked and critically analysed the original historical sources quoted in previous compilations and studies.
    Beschreibung: Published
    Beschreibung: 163-184
    Beschreibung: 5.1. TTC - Banche dati e metodi macrosismici
    Beschreibung: reserved
    Schlagwort(e): Historical Seismicity ; North Africa Earthquakes ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 5
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    Investigation of pre-1700 Earthquakes Between the Adda and the Middle Adige River Basins (Southern Alps) (2008)
    Springer
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: While the seismicity of the Southern Alps is high in the Eastern sector, corresponding to the Veneto and Friuli regions, it decreases towards West up to the Adda River. In the sector between the Lessini Mts. and Eastern Friuli the damaging earthquakes are clustered in a well defined seismic belt, where seismogenic sources responsible for earthquakes with Mw 6 have been defined in recent works. In contrast, the knowledge of the Southalpine sector West of this area is sparser; the area experienced some earthquakes with Mw〉5.5 and varied events with 4.8≤Mw≤5.5 the distribution of which is, apparently, random. For the area roughly defined by the basins of the Adda River to the West and the middle Adige River to the East, this paper reappraises the background knowledge of the earthquakes occurred before 1700. The investigation and the results are presented according to two successive periods, up to 1995 and from 1995 on. In the research performed up to 1995, the most important achievements concerned two different aspects: i) the assessement of several “fake quakes”, some of which were the object of paradigmatic case-histories; ii) the resizing and relocation of several, presumed damaging earthquakes. Though this round of investigation changed significantly the picture of the seismicity with respect to the Seventies, the research continued. For the period from 1995 on, the discussion focuses on the reliability of the available information; material that received little or no consideration before, new historical findings and comments to the seismological interpretation as in the most recent literature are also presented. This part includes also the discussion of archaeoseismological evidence of damage related to past earthquakes.
    Beschreibung: Published
    Beschreibung: 93-129
    Beschreibung: 3.10. Sismologia storica e archeosismologia
    Beschreibung: reserved
    Schlagwort(e): historical seismology ; Adda and Middle Adige River Basins ; Southern Alps ; archaeoseismology ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 6
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    In Troubled Times, in a Divided Country: The 1789 Valtiberina Earthquake (2008)
    Springer
    Details
    Publikationsdatum: 2017-04-03
    Beschreibung: The Valtiberina region (central Italy) has a seismic record going back to the Middle Ages and including five Io 〉 VIII MCS earthquakes, the earliest of which (1352, 1389, 1458). though recently and extensively studied, remain rather poorly known. This makes it all the more important to ensure that the later ones (1789, 1917) are as throughly studied as possible. The 1789 earthquake is listed by the current Italian catalogue (CPTI Working Group 2004) with Io VIII-IX MCS and Mm 5.8. These parameters were assessed from a database of 28 macroseismic intensity data points (Castelli et al. 1996), which is less than plentiful for a late 18th century earthquake. An analysis of the historical context of the 1789 earthquake and its influence on the production of contemporary accounts evidences a few research paths that previous studies either did not or could not take. Following them, the macroseismic database of the 1789 earthquake can be noticeably improved, providing the catalogue compiler with a mean to check the reliability of its current parameters.
    Beschreibung: Published
    Beschreibung: 249-260
    Beschreibung: 5.1. TTC - Banche dati e metodi macrosismici
    Beschreibung: open
    Schlagwort(e): Historical Seismicity ; 1789 Valtiberina Earthquake ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 7
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    Orbits (2008)
    Springer
    Details
    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/book
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  • 8
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    Dynamics of Complex Intracontinental Basins : the Central European Basin System (2008)
    Springer
    Details
    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/book
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  • 9
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    Preface to the special issue dedicated to Archaeoseismology (2007)
    Springer
    Details
    Publikationsdatum: 2020-11-30
    Beschreibung: This special issue of Journal of Seismology, dedicated to Archaeoseismology, shows the current trends of research in this young branch of seismology. The beginning of modern archaeoseismological practice during the 1980’s and the investigations made during the 1990’s were in many cases conditioned by the lack of cooperation among the spcialists from different scientific diciplines. Numerous publications resulted from the work of archaeologists, in some cases in collaboration with experts in earthquake-geology or seismology, but rarely such work included a complete and multidisciplinary approach and in situ analysis of the evidence. In many cases, archaeoseismological studies were limited to the detection of traces of past earthquakes in archaeological remains without a seismological perspective aiming to derive quantitative parameters necessary to fully describe a past earthquake (magnitude, etc.). In other cases, such investigations were limited to the analysis of archaeological reports of excavations made years or decades earlier. A step towards the quantification of seismological aspects was represented by the “territorial” approach, trying to reconstruct a picture of an earthquake by detecting its signs over a wider region. This procedure was, however, limited by the scarcity and reliability of published or unpublished archaeological material, usually adopted without a critical review.
    Beschreibung: Published
    Beschreibung: 393–394
    Beschreibung: 2TM. Divulgazione Scientifica
    Beschreibung: JCR Journal
    Beschreibung: open
    Schlagwort(e): Archaeoseismology, ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 10
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    Archaeoseismology: methodological issues and procedure (2007)
    Springer
    Details
    Publikationsdatum: 2012-02-03
    Beschreibung: Archaeoseismic research contributes important data on past earthquakes. A limitation of the usefulness of archaeoseismology is due to the lack of continuous discussion about the methodology. The methodological issues are particularly important because archaeoseismological investigations of past earthquakes make use of a large variety of methods. Typical in situ investigations include: (1) reconstruction of the local archaeological stratigraphy aimed at defining the correct position and chronology of a destruction layer, presumably related to an earthquake; (2) analysis of the deformations potentially due to seismic shaking or secondary earthquake effects, detectable on walls; (3) analysis of the depositional characteristics of the collapsed material; (4) investigations of the local geology and geomorphology to define possible natural cause(s) of the destruction; (5) investigations of the local factors affecting the ground motion amplifications; and (6) estimation of the dynamic excitation, which affected the site under investigation. Subsequently, a ‘territorial’ approach testing evidence of synchronous destruction in a certain region may delineate the extent of the area struck by the earthquake. The most reliable results of an archaeoseismological investigation are obtained by application of modern geoarchaeological practice (archaeological stratigraphy plus geological–geomorphological data), with the addition of a geophysicalengineering quantitative approach and (if available) historical information. This gives a basic dataset necessary to perform quantitative analyses which, in turn, corroborate the archaeoseismic hypothesis. Since archaeoseismological investigations can reveal the possible natural causes of destruction at a site, they contribute to the wider field of environmental archaeology, that seeks to define the history of the relationship between humans and the environment. Finally, through the improvement of the knowledge on the past seismicity, these studies can contribute to the regional estimation of seismic hazard.
    Beschreibung: Published
    Beschreibung: 395-414
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): archaeoseismology ; historical seismology ; geoarchaeology ; environmental archaeology ; natural catastrophes ; 04. Solid Earth::04.04. Geology::04.04.01. Earthquake geology and paleoseismology ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 11
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    The 1780 seismic sequence in NE Sicily (Italy): shifting an underestimated and mislocated earthquake to a seismically low rate zone (2007)
    Springer
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: The southernmost sector of the Italian peninsula is crossed by an almost continuous seismogenic belt capable of producing M ~ 7 earthquakes and extending from the Calabrian Arc, through the Messina Straits, as far as Southeastern Sicily. Though large earthquakes occurring in this region during the last Millennium are fairly well known from the historical point of view and seismic catalogues may be considered complete for destructive and badly damaging events (IX £ Io £ XI MCS), the knowledge and seismic completeness of moderate earthquakes can be improved by investigating other kinds of documentary sources not explored by the classical seismological tradition. In this paper, we present a case study explanatory of the problem, regarding the Ionian coast between the Messina Straits and Mount Etna volcano, an area of North-eastern Sicily lacking evidence of relevant seismic activity in historical times. Now, after a systematic analysis of the 18th century journalistic sources (gazettes), this gap can be partly filled by the rediscovery of a seismic sequence that took place in 1780. According to the available catalogues, the only event on record for this year is a minor shock (Io = VI MCS, Mw = 4.8) recorded in Messina on March 28, 1780. The newly discovered data allow to reinstate it as the mainshock (Io = VII–VIII MCS, Mw = 5.6) of a significant seismic period, which went on from March to June 1780, causing severe damage along the Ionian coast of North-eastern Sicily. The source responsible for this event appears located offshore, 40-km south of the previous determination, and is consistent with the Taormina Fault suggested by the geological literature, developing in the low seismic rate zone at the southernmost termination of the 1908 Messina earthquake fault.
    Beschreibung: Published
    Beschreibung: reserved
    Schlagwort(e): Historical seismology ; Macroseismic data ; MCS-EMS intensity scales ; 1780 Seismic sequence ; Seismotectonics ; NE Sicily ; 04. Solid Earth::04.06. Seismology::04.06.03. Earthquake source and dynamics ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: article
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  • 12
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    The 1138-1139 and 1156-1159 destructive seismic crises in Syria, south-eastern Turkey and northern Lebanon (2007)
    Springer
    Details
    Publikationsdatum: 2017-04-03
    Beschreibung: The aim of this study is to shed light ontwo important destructive seismicsequences, about 20 years apart (1138–1139and 1156–1159), which hit the northernsector of the Dead Sea transform faultsystem (DSTFS), in the easternMediterranean region. Although some ofthese earthquakes were already known to thescholarly tradition, the interpretationsprovided until today have largely beenpartial and characterised by uncertaintiesand discrepancies among the variousauthors. Our study has developed throughresearch into the original Arabic, Syriac,Armenian and Latin texts and a criticalanalysis relating to a territory fragmentedby the presence of the Christian-Latinstates. This analysis has allowed us toshed light on the already existing, albeitoften uncertain, information and to add newelements of these two important series ofearthquake shocks to our knowledge base.As regards the first seismic sequence(October 1138–June 1139), apart from havingdefined the date with greater accuracy,eight new locations affected have beenidentified, unknown to previous studies.The shocks jolted a vast area withdestructive effects, including theterritory of Aleppo (modern Halab, Syria)and the western part of the region ofEdessa (modern Urfa, Turkey).The second seismic sequence (September1156–May 1159) was much longer anddevastating, and hit a huge area, includedbetween the present-day territories ofnorth-western Syria, northern Lebanon andthe region of Antioch (modern Antakya, insouthern Turkey). A detailed analysis ofthe primary sources has allowed toreconstruct the series of shocks withchronological detail of the effects,improving our previous knowledge. Lastly,the authors formulate an hypothesis as tothe possible seismogenic zones affected.
    Beschreibung: Published
    Beschreibung: 105-127
    Beschreibung: 3.10. Sismologia storica e archeosismologia
    Beschreibung: JCR Journal
    Beschreibung: reserved
    Schlagwort(e): Historical earthquakes ; seismic sequences ; Lebanon ; Syria ; 04. Solid Earth::04.06. Seismology::04.06.99. General or miscellaneous ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
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  • 13
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    Late 17th century earthquakes on the North-African coast (2007)
    Springer
    Details
    Publikationsdatum: 2017-04-04
    Beschreibung: The recent seismological literature recorded three strong earthquakes in Algeria, Libya and Tunisia between 1656 and 1694 AD. The historical evidence for these derives from European sources only (gazettes, journalistic pamphlets, missionary literature). Considering the kind of sources involved, their likely biases and the geographical distances that divided their places of production from the places that they spoke about, it is possible that some of these accounts could be less than reliable, and therefore have little use as materials from which to assess earthquake parameters. To answer these doubts, we have retrieved, cross-checked and critically analysed the original historical sources quoted in previous compilations and studies.
    Beschreibung: Unpublished
    Beschreibung: 3.10. Sismologia storica e archeosismologia
    Beschreibung: open
    Schlagwort(e): Historical Seismology ; North Africa Earthquakes ; Early journalistic sources ; 04. Solid Earth::04.06. Seismology::04.06.05. Historical seismology
    Repository-Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Materialart: book chapter
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  • 14
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    The changing faces of the earth's magnetic field : a glance at the magnetic lithospheric field, from local and regional scales to a planetary view (2007)
    Commission for the Geological Map of the World
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    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/book
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  • 15
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    Continental Scientific Drilling : a decade of progress and challenges for the future (2007)
    Springer
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    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/book
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  • 16
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    Earthquake Early Warning Systems (2007)
    Springer
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    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/book
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  • 17
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    Earth Observation with CHAMP : Results from Three Years in Orbit (2005)
    Springer
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    Publikationsdatum: 2020-02-12
    Schlagwort(e): 550 - Earth sciences
    Materialart: info:eu-repo/semantics/book
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  • 18
    Digitale Medien
    Digitale Medien
    Method for culturing mammary epithelial cells in a rat tail collagen gel matrix (1983)
    Springer
    Methods in cell science 8 (1983), S. 31-36 
    Details
    ISSN: 1573-0603
    Schlagwort(e): growth ; differentiation ; mammary epithelium ; collagen gel
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary Mammary glands are enzymatically dissociated and the resulting tissue digest enriched for epithelial cells by isopycnic banding on a density gradient of Percoll. The cells are embedded within a rat tail collagen gel matrix and fed with the appropriate medium. Growth and differentiation are superior in such a system when compared to culture on plastic, using identical media.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01834632
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  • 19
    Digitale Medien
    Digitale Medien
    Cadralazine (ISF 2469): Dose-related antihypertensive activity after single oral administration to patients (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 157-161 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; cadralazine ; single dose ; dose response curve ; hypotensive action ; prolonged effect ; side effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Cadralazine (ISF 2469) was administered to 24 hypertensive patients in single oral doses of 7.5, 10, 15, 20 and 30 mg, according to a single-blind, placebo-controlled, within-patient change-over design. The study was done in 2 stages: in the first a range including the upper and lower doses was studied (7.5, 15, 30 mg and placebo), and in the second the range of doses was restricted (10, 15, 20 mg and placebo). The drug produced a significant decrease in blood pressure in the supine and standing positions. The decrease became clinically important starting from the 15 mg dose. Its action was still significant 12 h after administration. A significant increase in heart rate was also observed. All the effects were correlated with the dose. Side effects occurred mainly after the 30 mg dose. Thus, cadralazine, in a single oral dose in man, showed good antihypertensive activity starting from the 15 mg dose, and its effect was dose-related, slow in onset and long-lasting.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613810
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  • 20
    Digitale Medien
    Digitale Medien
    Increased oral clearance of metoprolol in pregnancy (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 217-220 
    Details
    ISSN: 1432-1041
    Schlagwort(e): metoprolol ; pregnancy ; hypertension ; kinetics ; pre-eclampsia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The disposition of oral metoprolol was studied in 5 women during the last trimester of pregnancy and 3 to 5 months after delivery. After a single oral dose of 100 mg the individual peak plasma concentration in the pregnant state was only 20–40% of that after pregnancy. The plasma half-lives of metoprolol were about the same during (average 1.3 h) and after pregnancy (average 1.7 h). By contrast, the area under the plasma concentration versus time curve was much smallerduring (mean 262 nmol/l×h) thanafter (mean 1298 nmol/l×h) pregnancy, resulting in an average apparent oral clearance (Clo) of metoprolol that was 4.4times higher during (362 ml×kg−1 body-weight×min−1) than after pregnancy. The increased Clo in pregnancy is assumed to be due to enhanced hepatic metabolism of the drug. The possible clinical consequence of the difference in the disposition of metoprolol is discussed.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613820
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  • 21
    Digitale Medien
    Digitale Medien
    Changes in renal function induced by endralazine, a new antihypertensive drug (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 307-314 
    Details
    ISSN: 1432-1041
    Schlagwort(e): endralazine ; hypertension ; blood pressure ; heart rate ; renal clearance ; plasma renin activity ; plasma aldosterone
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effects of endralazine, a new antihypertensive hydrazinopyridazine derivative, on heart rate, mean blood pressure (mBP), glomerular filtration rate (GFR), effective renal plasma flow (CPAH), urine volume (V), the clearance of Na, K, urea (Ur) and uric acid (UA), plasma renin activity (PRA) and plasma aldosterone (PA) were studied in hypertensive patients after a single oral dose of 10–15 mg, and after 8–17 days of treatment with daily doses of 15–90 mg. In the acute experiments, heart rate increased by 27%, mBP decreased on average by 17% and GFR by 33% and CPAH fell by only 5%. Urine volume and electrolyte clearance were also depressed. There was a significant increase in PRA and PA. The fall in GFR correlated directly with mBP, CPAH and the product (mBP×CPAH). The logarithms of the Na clearance and V were correlated with GFR and mBP. The logarithms of the fractional excretion of Na and water also correlated with mBP, suggesting that tubular reabsorption of sodium and water may be affected by change in mBP. The fractional potassium excretion correlated directly with CPAH and ln PA. In contrast, on sustained daily treatment, mBP was less depressed (9%), but GFR increased strikingly by 27% and CPAH by 46%. The body weight increased by 4.5% as a consequence of salt and water retention. GFR was correlated with CPAH, the product (mBP×CPAH) and the increase in body weight. Thus, the improvement in GFR and effective renal plasma flow observed under these conditions may be due, in part, to volume expansion. However, a direct renal vasodilating effect of the drug appears to be the more important determinant.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00610046
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  • 22
    Digitale Medien
    Digitale Medien
    Effect of indapamide on the baroreceptor reflex in essential hypertension (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 579-583 
    Details
    ISSN: 1432-1041
    Schlagwort(e): indapamide ; hypertension ; baroreflex ; vascular reactivity ; heart rate ; blood pressure change
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of chronic treatment with indapamide on blood pressure (BP), baroreceptor sensitivity (BRS) and vascular reactivity (VR) were investigated in 10 patients with essential hypertension. After 3 months of therapy with indapamide 2.5 mg/d the mean arterial pressure (MAP) had decreased from 135±6 to 112±2 mmHg (p〈0.001); the heart rate (HR) had not changed, VR had decreased from 6.1±1.2 to 4.8±1.8 (pg·min·kg)−1 (p〈0.05), and BRS had increased from 8.3±3.7 to 12.2±5.3 ms/mmHg (p〈0.005), with a leftshift of the relationship between BP and heart period. An inverse correlation was found between the pre-treatment systolic blood pressure and the change in baroreceptor sensitivity after indapamide (r=0.59; p〈0.05). In conclusion, chronic treatment with indapamide enhances BRS and resets the reflex. The resetting may account for the lack of tachycardia at rest observed after treatment with indapamide. The mechanism by which indapamide interferes with the baroreceptor reflex requires further investigations.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542204
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  • 23
    Digitale Medien
    Digitale Medien
    Plasma nifedipin levels and fall in blood pressure in a 53 year old woman (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 143-144 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; nifedipine ; plasma concentration ; blood pressure response
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00544032
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  • 24
    Digitale Medien
    Digitale Medien
    Sequential changes in plasma renin activity and plasma catecholamines in mildly hypertensive patients during acute, furosemide-induced body-fluid loss (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 299-302 
    Details
    ISSN: 1432-1041
    Schlagwort(e): furosemide ; hypertension ; plasma renin activity ; plasma adrenaline ; plasma noradrenaline ; body fluid loss ; diuretic response
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary To evaluate the role of adrenergic mechanisms in the acute response of renin to furosemide, plasma renin activity (PRA) and plasma catecholamine concentrations were measured for 3 h after i.v. administration of furosemide 1 mg/kg to 8 patients with mild essential hypertension. Furosemide induced a prompt and long-lasting increase in renin, with PRA more than doubled at all times. The increase in PRA within the first 30 min paralleled the peak increases in urinary water and sodium flow rates, and significant decreases in plasma volume and central venous pressure. There was no change in plasma catecholamine concentrations. Plasma noradrenaline was increased significantly at 60 min and adrenaline at 90 min, once furosemide had induced a marked loss of body-fluid and ∼65% decrease in central venous pressure. Both catecholamines remained elevated until the end of the study, whereas urinary water and sodium flow rates had returned to their pre-treatment values by 150 min. Mean blood pressure was essentially unchanged throughout the study, whereas heart rate increased significantly after 90 min. The findings suggest that in mildly hypertensive patients adrenergic mechanisms are not involved in the initial renin response to furosemide, but they come into play later, probably as a result of reflex sympathetic activation triggered by marked volume depletion.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01037937
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  • 25
    Digitale Medien
    Digitale Medien
    Ketanserin in essential hypertension: Effects during rest and exercise (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 307-312 
    Details
    ISSN: 1432-1041
    Schlagwort(e): ketanserin ; hypertension ; blood pressure ; plasma noradrenaline ; exercise ; orthostatic reflexes
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Ketanserin is a new, specific serotonin receptor blocking agent, which causes vasodilatation, presumably by an action on the vascular wall. The antihypertensive response to ketanserin 40 mg twice daily as monotherapy was assessed in 8 patients with essential hypertension. The investigation was an 8 week, double-blind, cross over study, which also included measurements during isometric (handgrip) and dynamic exercise (bicycle ergometry), as well as determination of plasma catecholamines and ketanserin. Ketanserin caused a reduction of supine and standing systolic and diastolic blood pressure (BP) during rest and a slight bradycardia. Although there was attenuation of the pressor response to handgrip, treatment with ketanserin did not really affect the changes in BP or heart rate during exercise, i.e. the base-line differences remained the same. There was no significant correlation between the effect on BP and the plasma level of ketanserin. The changes in BP produced by ketanserin showed little correlation with the initial levels of plasma catecholamines or with alterations in those levels. Although the results did not indicate direct interference by ketanserin with sympathetic tone, the lack of reflexogenic tachycardia, as well as the lack of increase in plasma noradrenaline during hand grip, indicates at least some modulation of autonomic function. It is concluded that ketanserin lowers BP in essential hypertension without interference with cardiovascular reflexes during standing or exercise, and that the compound may offer an alternative approach in the treatment of hypertension.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01037939
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  • 26
    Digitale Medien
    Digitale Medien
    Felodipine — A new vasodilator, in addition to β-receptor blockade in hypertension (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 571-575 
    Details
    ISSN: 1432-1041
    Schlagwort(e): beta-blocker ; felodipine ; calcium antagonist ; hypertension ; vasodilator ; side effects ; plasma levels ; metoprolol ; propranolol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In a double-blind, cross-over trial, 10 men with primary hypertension, not adequately controlled with a β-blocker alone, were also given felodipine or placebo for periods of one week. Placebo was administered single-blind for 2 weeks and 1 week, respectively, before randomization and between treatments. The dose of felodipine ranged from 6.25 mg to 25 mg. The addition of felodipine resulted in a pronounced (20%), statistically significant reduction in blood pressure (BP) and a small but significant increase in heart rate (HR). The effects were seen within 1–2 h and were maximal after 3–4 h. During steady state treatment the duration of BP reduction was at least 12 h. No orthostatic reaction was seen. There was a significant correlation between the plasma concentration of felodipine and change in BP. The most frequently reported side-effects were headache and ankle oedema, the latter probably being due to pronounced pre-capillary vasodilatation. There was no weight increase and thus no indication of general water retention. No clinically significant change in laboratory variables and no influence on the P-Q time were seen. Thus, felodipine in combination with a β-blocker seems to be a useful addition to the treatment of hypertensive patients whose BP is not adequately controlled with a β-blocker alone.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542340
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  • 27
    Digitale Medien
    Digitale Medien
    Cardiovascular response to exercise and regional haemodynamics during treatment with prizidilol hydrochloride (SK&F 92 657) in moderately severe essential hypertension (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 577-580 
    Details
    ISSN: 1432-1041
    Schlagwort(e): prizidilol ; hypertension ; exercise test ; beta-blockade ; vasodilatation ; haemodynamic effects ; vascular tone ; muscle blood flow
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Fourteen men with moderately severe essential hypertension were treated with prizidilol hydrochloride 400–700 mg once daily (mean±S.D. 612±56 mg/day). The study was open and ambulatory, with an initial placebo period followed by dose titration of prizidilol. Prior to treatment and during optimal control of blood pressure cardiovascular adaptation was examined in a submaximal exercise test. Plethysomographic assessment of vascular flow, resistance and tone in the calf musculature during supine rest and during maximal vasodilatation was also performed. A highly significant reduction in systolic (from 164±4.5 to 141±2.7 mmHg; p〈0.001) and diastolic blood pressure (from 105±1.6 to 87±1.3 mmHg; p〈0.001) at supine rest was noted during therapy with prizidilol. There was no significant change in heart rate. Systolic pressure in the standing position was reduced (from 159±4.2 to 139±2.9 mmHg; p〈0.001) and so was the diastolic pressure (from 111±2.5 to 95±1.9 mmHg; p〈0.001). The heart rate in the standing position was significantly increased compared to supine rest in the placebo period and during optimal treatment with prizidilol. The β-adrenoceptor blocking properties of prizidilol were apparent as a reduction in the exercise-induced heart rate response at even the lowest work load. During prizidilol therapy an increase in resting calf muscle blood flow was found from 3.1±1.5 ml/min·100 ml to 4.3±2.1 ml/min·100 ml (p〈0.025). Vascular resistance and vascular tone were significantly reduced. No change regarding blood flow or resistance during maximal vasodilatation was noted. It is considered that prizidilol has a clear antihypertensive effect combining β-receptor blocking and vasodilator properties.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542341
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  • 28
    Digitale Medien
    Digitale Medien
    Absence of an effect of mianserin on the actions of clonidine or methyldopa in hypertensive patients (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 15-19 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; mianserin ; clonidine ; methyldopa ; depression ; α2 receptors ; interaction
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The concurrent administration of tricyclic antidepressants has been shown in man to result in a clinically significant impairment of the antihypertensive effect of clonidine. This interaction is thought to be related to competition for central α2 receptors where clonidine acts as an agonist and the tricyclics act as antagonists. Although it seems to cause less cardiovascular effects than tricyclic antidepressants, the tetracyclic antidepressant, mianserin also has been reported to be an α receptor antagonist and may, therefore, also interfere with the antihypertensive activity of centrally-acting drugs. This study investigates the effects of acute and chronic mianserin administration in patients with essential hypertension established on long term treatment with either clonidine or methyldopa. The first dose of mianserin was not associated with an increase in blood pressure and during a further two weeks of mianserin therapy there were no significant alterations in blood pressure, supine or erect. Similarly, mianserin did not alter heart rate either after acute or after chronic administration. Mianserin itself had a sedative effect but there was no interference with the sedation attributable to clonidine or methyldopa. Mianserin caused no reduction in salivary flow and did not influence the reduced saliva production caused by clonidine. Both clonidine and methyldopa are associated with a reduction in sympathetic outflow but there was no evidence in this study of any further change in plasma noradrenaline or 24 h urinary catecholamine excretion. This study demonstrates that if mianserin is given acutely or chronically, it does not interfere with the effects of the centrally acting antihypertensive drugs, clonidine and methyldopa. Mianserin may therefore be a suitable antidepressant for patients receiving these antihypertensive agents if drug treatment for depression is indicated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613921
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  • 29
    Digitale Medien
    Digitale Medien
    Nifedipine in the treatment of difficult hypertensives (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 1-5 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; nifedipine ; calcium antagonists ; beta-blockers ; vasodilators ; diuretics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Nifedipine has been assessed as a possible alternative to other third line drugs in the management of patients with difficult to control hypertension. A group of 20 patients whose blood pressure was unsatisfactory on a 3 drug regimen had their third drug stopped and after a 2 week period nifedipine was added to their beta-blocker plus diuretic therapy. Eleven became normotensive on 30 mg nifedipine daily and a further 6 on 60 mg daily; giving on overall success rate of 85%. This result was achieved with a reduction in side effects and an absence of any haemodynamic or metabolic complications.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613919
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  • 30
    Digitale Medien
    Digitale Medien
    Endralazine, a new peripheral vasodilator. Evaluation of safety and efficacy over a 3 year period (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 301-305 
    Details
    ISSN: 1432-1041
    Schlagwort(e): endralazine ; hypertension ; pindolol ; peripheral vasodilator ; acetylator phenotypes ; antinuclear antibodies ; SLE-syndrome ; side-effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Nineteen out-patients with moderate to severe essential hypertension were treated daily for 3 years, with an average dose of 13 mg endralazine, a new peripheral vasodilator, in free combination with pindolol 3×5 mg. The blood pressure showed a statistically significant reduction from 172/110 mmHg to 154/92 mmHg after treatment for 3 weeks. Tachyphylaxis was not observed during the 3 year period. Oedema was the most frequent side-effect, but it disappeared spontaneously. No difference in efficacy and tolerance between slow and fast acetylators was found. Only 2 patients developed a weak positive antinuclear antibody titre, which disappeared spontaneously from one during continued treatment. No clinical evidence of a systemic lupus erythematosus-like syndrome was noted. It is concluded that the differences between endralazine and hydralazine in dosage and metabolism may explain the lower immunogenic activity of endralazine.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00610045
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  • 31
    Digitale Medien
    Digitale Medien
    Chronic propranolol administration during pregnancy (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 481-490 
    Details
    ISSN: 1432-1041
    Schlagwort(e): propranolol ; pharmacokinetics ; pregnancy ; hypertension ; naphthoxylactic acid
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The pharmacokinetics of propranolol (P) and its major metabolites, propranolol glucuronide (PGLUC), 4-hydroxypropranolol (4OHP), 4-hydroxypropranolol glucuronide (4OHPGLUC) and naphthoxylactic acid (NLA), (Walle et al. 1972) were determined, whenever possible, in the first, second and third trimesters of pregnancy in thirteen patients and also when these patients were at least three months post-partum. No correlations were found between the mean arterial blood pressure (post-therapy) or the fall in blood pressure as a result of the P therapy (p〉 〉0.05) and P dose, peak P plasma concentrations, peak 4-hydroxypropranolol (4OHP) plasma concentrations or peak (P plus 4OHP) plasma concentrations. However, a positive nonlinear relationship was found between the daily P dose (independent variable) and peak P plasma concentrations over the daily dose range 30–160 mg/day. The elimination half-lives of NLA for patients in the third trimester of pregnancy were significantly shorter (p=0.072, df=13) than those when the patients were at least three months post-partum. Also, the areas under the plasma level-time curves of NLA were significantly less (p〈0.05, df=13) for patients in the third trimester of pregnancy than when these patients were at least three months post-partum. The results of this study indicate that the pharmacokinetics of P, PGLUC, 4OHP and 4OHPGLUC are not significantly altered by pregnancy. However, the kinetics of NLA do appear to be altered. The formation of NLA by N-dealkylation of P and further oxidation, appears to be competitively inhibited by unidentified substances, perhaps endogenous steroids, especially in the third trimester when compared to at least three months post-partum.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542115
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  • 32
    Digitale Medien
    Digitale Medien
    Pinacidil, a new vasodilator: Pharmacokinetics and pharmacodynamics of a new retarded release tablet in essential hypertension (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 557-561 
    Details
    ISSN: 1432-1041
    Schlagwort(e): pinacidil ; hypertension ; side effects ; pharmacokinetics ; fluid retention ; retarded release tablet
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In an open study increasing doses of a retarded tablet formulation of pinacidil were given twice daily for four weeks to 9 patients with untreated essential hypertension (WHO I–II). In all patients a decrease in diastolic blood pressure to below 100 mmHg, or a fall exceeding 15 mmHg, was obtained 2 h after tablet intake (p〈0.02), but in only two patients was the effect maintained after 10 hours (n.s.). At a mean serum concentration of 100 ng/ml 2 h after pinacidil 30 mg, the mean blood pressure had decreased by 14 and 12.7 mmHg in the supine and erect positions, respectively (p〈0.05). In contrast, mean blood pressure 10 h after the same dose was unchanged, when the mean serum concentration was 47.5 ng/ml. No change in heart rate was observed. Pharmacokinetic and pharmacodynamic investigations showed a tendency towards a more gradual and longer lasting antihypertensive effect and serum concentration-time curve after the retarded tablet than the previous tablet. Pinacidil 40 mg in the retarded tablet reduced mean blood pressure and increased heart rate for at least 8 h. There was a linear correlation between the serum concentration and the changes in mean blood pressure, and between the changes in mean blood pressure and in heart rate. There was no indication of tachyphylaxis. A serum level of 50 ng/ml of pinacidil appeared to be the minimal effective concentration. The side effect consisted of fluid retention, and the body weight increased by 1.0 kg (p〈0.05); four patients complained of oedema. Therapy was discontinued in one patient after a fainting episode following an increase in the dose. Thus, pinacidil was able to lower blood pressure during monotherapy for 4 weeks provided that an adequate serum concentration was achieved. The present retarded tablet formulation is not suitable for b. d. dosing. The tendency towards fluid-retention suggests that pinacidil should be used in combination with a diuretic.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542128
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  • 33
    Digitale Medien
    Digitale Medien
    The effect of captopril and propranolol on the responses to posture and isometric exercise in patients with essential hypertension (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 721-728 
    Details
    ISSN: 1432-1041
    Schlagwort(e): captopril ; propranolol ; sympathetic nervous system ; noradrenaline ; aldosterone ; renin ; angiotensin converting enzyme ; hypertension ; isometric exercise
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effects of captopril and propranolol on blood pressure, heart rate and plasma noradrenaline, renin and aldosterone, and on the responses to changes in posture and to isometric exercise were measured in patients with essential hypertension. During placebo administration blood pressure, heart rate and plasma noradrenaline rose on standing and during isometric exercise. The rise in diastolic blood pressure during isometric exercise correlated significantly with the rise in plasma noradrenaline. During captopril treatment blood pressure was significantly lower than during placebo administration when the patients were lying, standing or sitting, but the reduction during isometric exercise was not significant. Plasma renin increased, but heart rate, plasma noradrenaline and plasma aldosterone remained unchanged. The acute changes in blood pressure, heart rate and plasma noradrenaline produced by standing and isometric exercise during captopril treatment were similar to those during placebo administration. During propranolol treatment diastolic blood pressure was significantly lower than during placebo administration when the patients were lying, standing or sitting and during isometric exercise. Heart rate also fell. Plasma noradrenaline during standing, sitting and isometric exercise was significantly greater than during placebo administration. The changes in plasma noradrenaline measured during propranolol treatment with the patients supine were negatively correlated with noradrenaline values obtained during placebo administration: plasma noradrenaline fell in patients with higher, and increased in those with lower, initial concentrations. The expected acute increase in heart rate on standing and during isometric exercise was blunted by propranolol, but the changes in blood pressure and plasma noradrenaline were unaffected. We conclude that in essential hypertension noradrenaline is involved in the pressor response to isometric exercise. Angiotensin converting enzyme inhibition by captopril did not interfere with the responses of the sympathetic nervous system to postural changes and isometric exercise. During propranolol treatment there was no evidence that reduced sympathetic activity was involved in the hypotensive response.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542509
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  • 34
    Digitale Medien
    Digitale Medien
    Acute antihypertensive effect and pharmacokinetics of a tablet preparation of nifedipine (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 145-150 
    Details
    ISSN: 1432-1041
    Schlagwort(e): nifedipine ; hypertension ; pharmacokinetics ; tablet formulation ; dose-response
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A tablet formulation of nifedipine was given to 8 hospitalized hypertensive men, W.H.O. stage I or II, mean age 45 years. After an initial placebo test, nifedipine 20, 40 or 60 mg was given in random order at 72-h intervals, in a single administration crossover study. The placebo and the active drug were given at 8 a.m. Blood pressure and heart rate were measured twice by the same observer, every 20 min from 7 to 8 a.m., and then hourly until 8 p.m., first in recumbency and again after 1 min of standing upright. Plasma nifedipine was assayed in samples taken hourly from 8 a.m. to noon, every 2 h from noon to 8 p.m., and 24 and 48 h after drug administration. All 3 doses significantly lowered blood pressure; the fall during recumbency was significantly larger (−18%) and lasted longer (12 h) after 60 mg than after 20 mg (−11% and 7 h). All 3 doses caused a similar increase in heart rate (+29 to +38%), which reached its maximum after 2 h and lasted for 5 h. The maximum plasma concentration and the area under the plasma concentration — time curve were dose-dependent despite large inter-subject variation. Absorption, bioavailability and elimination were linear between the 20 and 60 mg doses. Plasma nifedipine levels were strongly correlated with the concomitant decrease in mean arterial blood pressure (r=0.61,p〈0.001). Four patients experienced mild side effects (headaches, flushes, drowsiness or weakness). This tablet form of nifedipine has a potent antihypertensive action which lasts longer than that of the capsule presentation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613808
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  • 35
    Digitale Medien
    Digitale Medien
    Pharmacokinetics of oral hydralazine in chronic heart failure (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 467-473 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hydralazine ; heart failure ; pharmacokinetics ; bioavailability ; metabolism ; hypertension ; dapsone ; acetylator phenotype
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The influence of various disease states, other than hypertension, on the pharmacokinetic behaviour of hydralazine is not completely known. In the present study the pharmacokinetics of oral hydralazine has been evaluated in 7 patients with severe, chronic heart failure, using 8 compensated hypertensives as controls. The pharmacokinetics was evaluated by measuring the plasma concentrations of hydralazine (“apparent” and “real” hydralazine) and hydralazine pyruvate hydrazone, and by assessing acetylator phenotype after a small dose of dapsone. The AUC (area under the plasma concentration curve) following a single, oral 50 mg dose was significantly larger in patients with chronic heart failure NYHA Class III–IV than in patients with essential hypertension without cardiac decompensation. A decreased rate of hepatic elimination of hydralazine is suggested as a major contributory factor to this finding.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542113
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  • 36
    Digitale Medien
    Digitale Medien
    Pharmacokinetic aspects of guanfacine withdrawal syndrome in a hypertensive patient with chronic renal failure (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 463-466 
    Details
    ISSN: 1432-1041
    Schlagwort(e): guanfacine ; hypertension ; phenobarbital ; withdrawal syndrome ; enzyme induction ; pharmacokinetics ; renal insufficiency
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The unusual observation of a withdrawal syndrome due to guanfacine in a hypertensive patient with chronic renal failure led to a study of the kinetics of the drug in this patient. The principal pharmacokinetic parameters of guanfacine were greatly altered, with extended biotransformation and a decrease in the half-life compared to the values observed in other cases of severe renal insufficiency. Associated treatment with phenobarbital had had a considerable effect, as shown by the results of a further kinetic study 2 months after withdrawal of the phenobarbital. The findings then were in good agreement with reference values which strongly suggests a consequence of the enzyme inducing effect of phenobarbital. Advice about the dosage regimen in such cases is given.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542112
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  • 37
    Digitale Medien
    Digitale Medien
    Nifedipine in the treatment of hypertension (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 713-715 
    Details
    ISSN: 1432-1041
    Schlagwort(e): nifedipine ; hypertension ; calcium antagonist ; plasma renin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Nifedipine, a calcium antagonist with a predominant vasodilator action, was evaluated for the treatment of hypertension. A 20 mg-tablet, with a slower absorption and a more sustained blood-level than provided by the 10 mg-capsule was administered to 20 patients. The duration of the trial was 20 weeks. All patients achieved a significant reduction in both systolic (p〈0.05) and diastolic (p〈0.001) blood-pressure (B.P.), but 10 patients were withdrawn before completion of the trial period. Two patients, although achieving a fall in B.P. which was significant, did not reach to target level (〈160/90) on maximal dosage, one patient suffered a stroke due to a cerebral infarct, and seven patients were withdrawn because of side-effects due mainly to vasodilatation. The remaining 10 patients obtained a satisfactory response. In nine patients, who had achieved a satisfactory result, there was no change in plasma renin activity (P.R.A.) during chronic nifedipine administration.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542507
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  • 38
    Digitale Medien
    Digitale Medien
    Long term treatment with tienilic acid or thiazides: Comparison of antihypertensive and metabolic effects (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 835-837 
    Details
    ISSN: 1432-1041
    Schlagwort(e): tienilic acid ; hydrochlorothiazide ; amiloride ; blood pressure control ; biochemical effects ; serum uric acid ; serum potassium ; prolonged treatment ; hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A comparison has been made of arterial pressure and major metabolic parameters during long term treatment with tienilic acid and a hydrochlorothiazide-amiloride combination, using a randomized single-blind study without cross-over. A significant fall in systolic and diastolic blood pressure and no change in most biochemical parameters was observed with both drugs. Serum uric acid concentration was decreased during tienilic acid and was slightly increased whilst subjects took the hydrochlorothiazide-amiloride combination; serum potassium was slightly decreased on tienilic acid. No sign of hepatotoxicity was detected.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542531
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  • 39
    Digitale Medien
    Digitale Medien
    Relationship between pharmacokinetic and pharmacodynamic behaviour of bufuralol and its metabolite Ro 3-7410 in hypertensive patients (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 479-484 
    Details
    ISSN: 1432-1041
    Schlagwort(e): bufuralol ; hypotensive therapy ; pharmacokinetics ; hypertension ; 1-hydroxybufuralol
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The relationship between the plasma concentrations of bufuralol and its major hydroxymetabolite (Ro 3-7410) and β-blocking activity was studied in 10 patients with uncomplicated essential hypertension. Blood samples and haemodynamic data were obtained during rest and after a single-level exercise test on a bicycle cycloergometer, prior to and up to 32 h after administration of a single oral dose of bufuralol 30 mg. Bufuralol was rapidly absorbed, following a first-order process with a lag time. The calculated maximal plasma concentration ranged from 44.6 to 200.3 ng/ml. The half-life of bufuralol was 2.75±1.15 h (mean±SD). Up to 50% of the parent drug was transformed into Ro 3-7410, which showed less interpatient variability in concentration and a fairly constant half-life, which was three times longer than that of the parent drug. In general, the heart rate (HR) was slightly decreased, although 2/10 patients showed an initial increase. The resting HR returned to its pre-treatment level within 6 h, the exercise HR took up to 32 h to return to the pre-treatment level. The drug reduced both resting and exercise blood pressure (BP). The former was reduced from 153.0±14.2/93.5±8.5 to 134.5±14.0/77.0±6.8 mmHg (systolic/diastolic BP; mean±SD) with 6 h after treatment. Similarly, the exercise BP was reduced from 199.0±15.2/98.5±8.8 to 171.0±9.9/88.5±8.5 mmHg at the 6th h post-dosing. The BP values had not returned to their pre-treatment levels even 32 h after treatment. Thus, bufuralol and its metabolite Ro 3-7410 induced a long-lasting antihypertensive effect and inhibited the cardio-acceleratory effect of exercise, and there was a good correlation between the pharmacokinetic and pharmacodynamic behaviour of the drug.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00609890
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  • 40
    Digitale Medien
    Digitale Medien
    Comparison of the antihypertensive effect of a double dose of metoprolol versus the addition of hydrochlorothiazide to metoprolol (1983)
    Springer
    European journal of clinical pharmacology 25 (1983), S. 581-583 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; metoprolol ; hydrochlorothiazide ; drug combination ; adverse reactions
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary In 27 hypertensive patients whose blood pressure could not be adequately controlled with 200 mg metoprolol Durules alone, the effect of a double dose of metoprolol Durules® (400 mg once daily) was compared with a fixed combination of 200 mg metoprolol and 25 mg hydrochlorothiazide (Selokomb®). The study followed a double-blind cross-over schedule in 2 parallel groups. The reduction in diastolic blood pressure (p〈0.01) was comparable in the two groups. A significant fall (p〈0.01) in systolic blood pressure occurred with the metoprolol/hydrochlorothiazide combination. The subsequent change from the double dose of metoprolol Durules to the combination therapy also resulted in a fall in systolic blood pressure (p〈0.05). Mean serum potassium and blood glucose levels did not change after each alteration in therapy. Most of the side-effects mentioned were mild and transient in character.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542342
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  • 41
    Digitale Medien
    Digitale Medien
    Atenolol and metoprolol: Comparison of effects on blood pressure and serum lipoproteins, and side effects (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 573-577 
    Details
    ISSN: 1432-1041
    Schlagwort(e): beta-blockers ; serum lipoproteins ; atenolol ; metoprolol ; hypertension ; VLDL ; HDL ; hypertriglyceridaemia ; hypercholesterolaemia ; side effects
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary Several β-blockers increase VLDL-TG and decrease HDL-cholesterol concentrations. The underlying mechanism ist not yet clear. Some studies have suggested that the effect is less pronounced during treatment with selective β-blockers. The effects of 2 such drugs, metoprolol 200 mg/day and atenolol 50 mg/day, have been compared in 50 hypertensive patients (WHO Stage I–II), mean age 47 years. Serum lipoproteins were determined in 20 patients before treatment and after treatment with either drug for 3 months. Both drugs were equally effective in reducing blood pressure. After atenolol the initial VLDL-cholesterol concentration of 1.04 mmol/l had not changed, but it rose to 1.29 mmol/l after metoprolol (p〈0.05). The HDL-cholesterol concentration 1.42 mmol/l did not fall during atenolol treatment, but during metoprolol there was a small reduction to 1.31 mmol/l (p〈0.05). Hyperlipoproteinaemia is common in hypertensive patients, 40% of the present group had hypertriglyceridaemia and 25% had hypercholesterolaemia. Thus, atenolol 50 mg was found not to affect lipoproteins, whereas metoprolol 200 mg increased the VLDL concentration in 75% of the patients.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00542203
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  • 42
    Digitale Medien
    Digitale Medien
    Haemodynamic effects of a new vasodilator drug, felodipine, in healthy subjects (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 49-53 
    Details
    ISSN: 1432-1041
    Schlagwort(e): felodipine ; hypertension ; cardiac failure ; haemodynamic effects ; non-invasive monitoring
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The haemodynamic effects of a new vasodilating drug, felodipine, were studied in eight, healthy, male subjects, aged 22–31 years. The drug was given as an oral solution in the dose of 0.15 mg/kg. Thirty-five minutes later further dose of 0.15 mg/kg was administered. Felodipine induced a pronounced decrease in diastolic blood pressure (maximal effect 15±4 mm Hg) and in the systemic vascular resistance. Cardiac output increased (maximum by 4.2±0.3 l/min), due to an increase both in the stroke volume and the heart rate. The maximal increase in the stroke volume (measured from echo cardiograms) and the heart rate were 33±5 ml and 23±3 beats/min, respectively. Felodipine caused a significant decrease in the pre-ejection period (23±3 ms) and an increase in the left ventricular ejection time (29±3 ms). The quotient PEP/LVET fell from 0.36±0.01 to 0.28±0.01. Significant activity of felodipine could be recorded at a plasma level of about 15 nmol/l. When the maximal haemodynamic effects were recorded the plasma level was about 40 nmol/l. After a cumulative dose of 0.30 mg/kg, there was a twofold variation in the maximal plasma level (from 31 to 61 nmol/l). The results of the present investigation are in agreement with previous haemodynamic studies in animals. It would appear that felodipine is a potent arteriolar vasodilator and it might well be of considerable value in the management of patients with hypertension or congestive cardiac failure.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613926
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  • 43
    Digitale Medien
    Digitale Medien
    A naturalistic study of hypertension in a rural U.K. community (1983)
    Springer
    European journal of clinical pharmacology 24 (1983), S. 191-197 
    Details
    ISSN: 1432-1041
    Schlagwort(e): hypertension ; beta-blocker ; diuretic ; screening ; naturalistic
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A naturalistic study was set up to screen, identify and treat hypertensive patients aged 20–60 years in a rural general practice. 3,222 patients (92%) of a stable population of 3,489 were screened by 2 nurse research assistants and of these 455 patients (14%) were found to be hypertensive or borderline hypertensive. After careful assessment, 192 of these patients were found suitable for treatment and subsequently 138 entered the study. Two well recognised treatment regimes were used and no significant difference between patient response resulted. 84 patients (60.9%) completed the 2 year duration of the study discussed here. The cost of the study is not feasible in an average general practice, but day to day running of such a project, run along clearly defined treatment regimes was managed easily by 2 research assistants: this reduced, therefore, the work load on individual general practitoners.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00613816
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  • 44
    Digitale Medien
    Digitale Medien
    Hidden breaks in ribosomal RNA of phylogenetically tetraploid fish and their possible role in the diploidization process (1983)
    Springer
    Biochemical genetics 21 (1983), S. 819-841 
    Details
    ISSN: 1573-4927
    Schlagwort(e): evolution ; polyploidy ; ribosomal RNA ; protein synthesis ; gene expression
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Chemie und Pharmazie
    Notizen: Abstract Hidden breaks occur in the ribosomal RNA of tetraploid Cyprinid fish such that the large ribosomal RNA (28 S) yields upon denaturation two RNA fragments of 8.7×105 and 5.0×105 daltons, whereas the small rRNA (18 S) yields fragments of 3.2×105 to 5.0×104 daltons. In tetraploid Cyprinids hidden breaks occur only in the rRNA of somatic tissue and not in oocytes and sperm cells. Hidden breaks can be detected only slightly in diploid Cyprinid species. Ribosomes purified from somatic tissue of tetraploid Cyprinids show a reduced efficiency in protein synthesis in vitro. The ribosomal proteins from diploid and tetraploid Cyprinid fish show considerable electrophoretic differences. This is discussed in light of a possible functional role of hidden breaks in rRNA in the process of diploidization of gene expression in tetraploid Cyprinid species.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00498929
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  • 45
    Digitale Medien
    Digitale Medien
    Synthesis of the large subunit of ribulose-1,5-bisphosphate carboxylase in anin vitro partially definedE. coli system (1983)
    Springer
    Plant molecular biology 2 (1983), S. 279-290 
    Details
    ISSN: 1573-5028
    Schlagwort(e): spinach chloroplast DNA ; gene expression ; initiation of transcription
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Thein vitro DNA- or RNA-directed synthesis of the large subunit (LS) of spinach chloroplast ribulose-1,5-biphosphate carboxylase (RuP2C) has been examined in a highly definedE. coli transcription-translation system. Spinach chloroplast DNA, RNA and recombinant plasmids containing the spinach chloroplast LS gene (rbcL) have been used as templates in thein vitro system and a quantitative assay has been developed to measure LS formation. Thein vitro formed product contains formylmethionine at the N-terminal position and sediments primarily as a monomer. There is no detectable enzymatic activity associated with thein vitro product. To determine where theE. coli RNA polymerase used in these systems initiates, we have examined the transcripts produced by this enzymein vitro. Measurements of run-off transcripts indicate thatE. coli RNA polymerase initiates at the same position on the gene as is seenin vivo. In addition, the complete nucleotide sequence of therbcL gene including previously unsequenced 3′ and 5′ flanking regions has been determined. The sequence agrees, except at two nucleotide positions, with previously published sequencing data for this gene (Zurawski, G, Perrot, B, Bottomley, W, Whitfeld, PR, 1981. Nucleic Acids Res. 9:3251–3270).
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01578646
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  • 46
    Digitale Medien
    Digitale Medien
    Effect of the sympathetic nervous system on change in resistance of the blood—brain barrier in arterial hypertension (1983)
    Springer
    Bulletin of experimental biology and medicine 95 (1983), S. 412-414 
    Details
    ISSN: 1573-8221
    Schlagwort(e): brain ; blood-brain barrier ; hypertension ; angiotensin ; noradrenalin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00838842
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  • 47
    Digitale Medien
    Digitale Medien
    Dependence of number of vesicles in vascular smooth muscle cells on extracellular calcium concentration (1983)
    Springer
    Bulletin of experimental biology and medicine 96 (1983), S. 1631-1633 
    Details
    ISSN: 1573-8221
    Schlagwort(e): smooth muscles ; calcium ; intracellular vesicles ; hypertension
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00835313
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  • 48
    Digitale Medien
    Digitale Medien
    Differences in growth of perch (Perca fluviatilis L.) in two small forest lakes (1983)
    Springer
    Hydrobiologia 101 (1983), S. 139-143 
    Details
    ISSN: 1573-5117
    Schlagwort(e): forest water ecosystems ; perch ; growth ; forest lake ; population density ; bottom fauna ; zooplankton
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Growth patterns and food composition of perch, Perca fluviatilis L., was studied in two small forest lake populations in southern Finland. Size and morphometry of the lakes and physical and chemical properties of water are similar. There is a clear difference in the growth rates of perch between the two lakes. The difference in growth is highly significant in all age groups. In the first lake there is a perch population of 2 000 (1750 ind · ha−1) adult fishes. In the second lake there is a small population of pike, that keeps the perch population down: 200 adult perch (530 ind · ha-1). The main food items of perch are crustacean zooplankton, Asellus aquaticus L. and Trichoptera larvae in the first lake and zooplankton, Odonata larvae, Ephemeroptera larvae and Heteroptera in the second. It is concluded that the main reason for the growth difference of studied perch populations is the different population density. There are also differences in species composition of bottom fauna of the lakes, maybe owing to the floating Sphagnum peat moss vegetation in the second lake. This can also affect the growth difference between the two populations of perch.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00008666
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  • 49
    Digitale Medien
    Digitale Medien
    Changes in growth and size of Keratella cochlearis (Gosse) in relation to some environmental factors in cultures (1983)
    Springer
    Hydrobiologia 104 (1983), S. 325-328 
    Details
    ISSN: 1573-5117
    Schlagwort(e): rotifers ; Keratella cochlearis ; growth ; size ; culture ; food algae
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Abstract Keratella cochlearis (Gosse) was cultured non-axenically in Carefoot medium diluted with Erken water at 5 °C, 15 °C and 20 °C with Rhodomonas minuta (Skuja) as a food alga. The rotifer reached ca. 120 ind. ml−1, having generation times of 2–7 days, a Q10-value of ca. 2, and at the lowest temperature 〉20% longer posterior spines. When co-cultured with Chlorella sp., at 0–30 mg Ca l−1 and 1.6 meq NaHCO3 l−1 in medium L 11 at 20 °C, the maximum generation time and individual numbers were 3–4 days and up to 100 ind. ml−1, respectively. Animal numbers increased in relation to nutrient multiples, up to two multiples, of the culture medium L 16. Growth and length were reduced, although the width increased above two multiples of this culture medium. The trace metal tolerance was broad and increased additions of a metal mixture (L 11) slightly increased the length of the rotifers. No major changes in the length were observed when HCO3 or Ca were varied in the culture medium (L 11), although a decrease in the length was noted in old cultures.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00045985
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  • 50
    Digitale Medien
    Digitale Medien
    Effect of incorporating ragi (Eleusine Coracana) husk in semisynthetic diets (1983)
    Springer
    Plant foods for human nutrition 33 (1983), S. 279-285 
    Details
    ISSN: 1573-9104
    Schlagwort(e): Ragi husk ; N-retention ; growth ; body composition ; feed efficiency ratio
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft
    Notizen: Abstract The effect of including ragi husk in the diet, at the 8 per cent level, on growth and body composition of pair-fed albino rats was studied. Even on equal food intake by both control as well as the experimental animals, the incorporation of ragi husk promoted better growth, nitrogen retention and protein efficiency ratio. Protein content of the carcass and liver of rats fed diets containing ragi husk was higher than the control group. The growth response of rats fed ragi husk appeared to increase with the content of nitrogen in the husk.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01094753
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  • 51
    Digitale Medien
    Digitale Medien
    Rapid control of hypertension with oral bethanidine (1972)
    Springer
    European journal of clinical pharmacology 4 (1972), S. 217-221 
    Details
    ISSN: 1432-1041
    Schlagwort(e): Bethanidine ; guanethidine ; hypertension ; adrenergic blockade ; blood pressure ; dose response
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary A dosing schedule for the administration of oral bethanidine is described, which achieved optimal cumulative effect in each of 8 patients in 3 days or less. Individual patient dosage titration is necessary, because the required cumulative dose cannot be predicted on the basis of blood pressure, or creatinine clearance. The time course of the blood pressure response after the peak acute hypotensive effect was found to be variable and dependent upon the magnitude of effect and time of day. No blood pressure effect was noted in the recumbent position.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00635799
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  • 52
    Digitale Medien
    Digitale Medien
    The effect of pindolol, a beta-receptor blocking agent, in heart rate and blood-pressure during submaximal and maximal exercise (1972)
    Springer
    European journal of clinical pharmacology 4 (1972), S. 228-232 
    Details
    ISSN: 1432-1041
    Schlagwort(e): beta-blockade ; substituted indoles ; hypertension ; work capacity ; clinical trial
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Chemie und Pharmazie , Medizin
    Notizen: Summary The effect of a new beta-receptor blocking agent, 4-2 (2-hydroxy-3-isopropylaminopropoxy)-indole, pindolol (Viskén®), was investigated in patients with essential hypertension of WHO grades I–II. Maximal and submaximal working capacity tests were done before and during treatment in 30 patients. 15 patients underwent a double-blind cross-over trial with placebo; and a further 15 patients were examined in an open study including a multiscaled working capacity test. The work tests were performed on a bicycle ergometer with increasing loads. The ECG was recorded continuously, and the blood-pressure was measured with a cuff. — In both groups the heart rate and systolic blood-pressure decreased significantly during treatment with Viskén, both at rest and during exercise. The resting and post-exercise diastolic blood-pressures were also significantly reduced after beta-receptor blockade with Viskén. No ECG signs of myocardial ischemia were found. The work capacity tests showed a slight reduction, of about 100 kpm/min, in four patients, whilst three improved their maximal working capacity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00635801
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