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  • Drosophila melanogaster  (81)
  • hypertension  (77)
  • Springer  (158)
  • American Chemical Society
  • American Meteorological Society
  • Nature Publishing Group
  • Springer Nature
  • 1985-1989  (115)
  • 1975-1979  (32)
  • 1970-1974  (11)
  • 1960-1964
  • 1950-1954
  • 1988  (47)
  • 1985  (68)
  • 1979  (32)
  • 1974  (10)
  • 1971  (1)
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  • Springer  (158)
  • American Chemical Society
  • American Meteorological Society
  • Nature Publishing Group
  • Springer Nature
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Years
  • 1985-1989  (115)
  • 1975-1979  (32)
  • 1970-1974  (11)
  • 1960-1964
  • 1950-1954
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  • 1
    Electronic Resource
    Electronic Resource
    Search orientation in adultDrosophila melanogaster: Responses of rovers and sitters to resource dispersion in a food patch (1988)
    Springer
    Journal of insect behavior 1 (1988), S. 209-223 
    Details
    ISSN: 1572-8889
    Keywords: Drosophila melanogaster ; searching behavior ; foraging ; genetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Drosophila melanogasteradults were employed in single resource patches of varying density and size and in a multiple-patch array to determine the degree to which resource dispersion influences searching success. Individuals from rover and sitter selected lines, with extreme genotypes for local search duration, are not as successful as control-line (wild-type) flies in locating sucrose drops in single patches varying in size and density. The number of new drops located differed significantly between fly lines in all patch types, except in a high-density patch, and within each fly line over the different patch sizes and densities. The similarities in number of drops found by rovers and sitters in all patch types are not reflected in the time periods spent searching. In the multiple-patch array sitters never left the central patch, whereas most rovers and con-trol-line flies found additional patches. The proximate explanations for the success or failure of the three fly lines in different patch sizes and densities relate to the looping locomotor pattern characterizing local search in D. melanogaster.The reactivation of searching each time a drop is ingested or revisited keeps an individual in the immediate vicinity of the last encountered resource. Flies from the selected lines, each exhibiting extreme types of locomotor patterns, leave patches relatively unexploited because local search consists either of rapid, nearly linear movement away from a drop in rovers or of relatively long bouts of local search in sitters, which promotes revisiting rather than locating new drops. Control-line flies locate more drops than either rovers or sitters and in less time than sitters, suggesting that their intermediate phenotype for search behavior allows for more flexibility in searching in various patch sizes and resource densities. The results are discussed with reference to environmental and physiological factors that may modify searching behavior and, possibly, enhance the survival of individuals with extreme genotypes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01052239
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  • 2
    Electronic Resource
    Electronic Resource
    Temperature-dependent responses to a developmental gradient in theDrosophila wing (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1346-1347 
    Details
    ISSN: 1420-9071
    Keywords: Positional information ; temperature effects ; gradients ; campaniform sensillae ; wing veins ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The mutant hairy (h) increases the number of sensillae on theDrosophila wing. This allows us to quantify a gradient that determines the type of sense organ that forms along the third long vein. Temperature significantly shifts the positional responses to this underlying gradient.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952088
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  • 3
    Electronic Resource
    Electronic Resource
    The effect of DDT on DNA replication in the larval salivary gland cells ofDrosophila melanogaster (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 745-746 
    Details
    ISSN: 1420-9071
    Keywords: Drosophila melanogaster ; salivary gland ; larval ; DNA replication ; DDT ; chromosomes ; polytene
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The inhibitory effect of DDT on the initial stage of the DNA replication process in polytene chromosomes of larval salivary gland cells ofDrosophila melanogaster was investigated and possible mechanisms for the inhibition are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02012576
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  • 4
    Electronic Resource
    Electronic Resource
    Acetaldehyde oxidation inDrosophila null-mutants for alcohol dehydrogenase (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 946-948 
    Details
    ISSN: 1420-9071
    Keywords: Acetaldehyde oxydation ; alcohol dehydrogenase ; aldehyde dehydrogenase ; Drosophila melanogaster ; Drosophila simulans ; ethanol catabolism ; null-mutants for alcohol dehydrogenase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Aldehyde dehydrogenase (ALDH) activity is demonstrated in four strains ofD. melanogaster lacking active alcohol dehydrogenase (ADH-null mutants). In the four strains, ALDH activities are similar to those found in a wild strain. It is concluded that ADH-null flies are able to detoxify acetaldehyde. This finding is discussed in relation with the dual function of ADH proposed recently.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01970027
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  • 5
    Electronic Resource
    Electronic Resource
    Effect of intercalating mutagens on crossing-over inDrosophila melanogaster females (1985)
    Springer
    Cellular and molecular life sciences 41 (1985), S. 1078-1079 
    Details
    ISSN: 1420-9071
    Keywords: Drosophila melanogaster ; intercalating mutagens ; crossing-over ; clastogenic activity ; recombination induction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary In order to evaluate the effect of several intercalating compounds on crossing-over inDrosophila melanogaster females, acridine orange, acriflavine, chloroquine, ethidium bromide and quinacrine were fed separately to larvae ofy ct f/+++ genotype. Our results show that acridine orange, acriflavine and ethidium bromide increase significantly the recombination frequency at thect-f region and support the view that, for intercalating agents, there is a relationship between clastogenic activity and female recombination induction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01952152
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  • 6
    Electronic Resource
    Electronic Resource
    The sensitive period for yellow phenocopy induction inDrosophila melanogaster (1988)
    Springer
    Cellular and molecular life sciences 44 (1988), S. 618-621 
    Details
    ISSN: 1420-9071
    Keywords: Sensitive period ; phenocopy ; yellow ; survivorship ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Yellow phenocopies ofDrosophila melanogaster were produced by raising larvae on α-DMT contaminated media. Using a survivorship test, the sensitive period for phenocopy induction was found to occur during the third larval instar of development, with increased survivorship at 1% α-DMT compared with lower concentrations. It was also found that treatment with α-DMT significantly slowed development. These findings are related to the relevant morphological and behavioral developmental pathways and to phenocopy induction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01953317
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  • 7
    Electronic Resource
    Electronic Resource
    Partial cytoplasmic incompatibility between two Australian populations of Drosophila melanogaster (1988)
    Springer
    Entomologia experimentalis et applicata 48 (1988), S. 61-67 
    Details
    ISSN: 1570-7458
    Keywords: cytoplasmic incompatibility ; Drosophila melanogaster ; maternal inheritance ; reproductive isolation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Description / Table of Contents: Résumé Les souches de D. melanogaster récoltées à Melbourne (37°S) et Townsville (19°S) sur la côte Est de l'Australie montrent une incompatibilité partielle lorsque les femelles Melbourne sont accouplées aux mâles Townsville. Une telle incompatibilité n'est décelée, ni dans les croisements intrapopulations, ni dans le croisement réciproque. Le taux d'éclosion des oeufs est réduit d'environ 30% dans le croisement incompatible, mais la viabilité des larves n'est pas modifiée. Les éléments, mâle et femelle, de ce système d'incompatibilité sont hérités maternellement pendant 3 générations de croisements en retour. La compatibilité peut être intégralement rétablie en cultivant pendant une génération la souche Townsville avec un régime contenant de la tétracycline, et partiellement rétablie en utilisant des mâles âgés de 2 semaines.
    Notes: Abstract Drosophila melanogaster (Meigen) females from stocks collected at Melbourne (latitude 37°S) show partial incompatibility when mated with males from stocks collected at Townsville (latitude 19°S) on the east coast of Australia. The reciprocal cross is compatible. Eggs have reduced hatchability in the incompatible cross. The incompatibility is maternally inherited over three generations. Compatibility can be restored by culturing Townsville flies on medium with tetracycline for one generation and by using 2-week-old Townsville males.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00343386
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  • 8
    Electronic Resource
    Electronic Resource
    Recent origin for a thermostable alcohol dehydrogenase allele ofDrosophila melanogaster (1988)
    Springer
    Journal of molecular evolution 27 (1988), S. 142-146 
    Details
    ISSN: 1432-1432
    Keywords: Drosophila melanogaster ; Adh ; Thermostable allele ; DNA sequence
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The nucleotide sequence of theFast-Chateau Douglas isolate of the thermostable alcohol dehydrogenase allele is compared with the sequences of theSlow andFast alleles ofDrosophila melanogaster. Conceptual translation of theFChD sequence indicates that the thermostable polypeptide has the diagnostic FAST amino acid replacement at residue 192 and an additional replacement of serine for proline at residue 214. This suggests aFast origin for the thermostableAdh allele. However, some of the biochemical properties of the FCHD protein resemble those of the SLOW rather than the FAST polypeptides. The serine for proline replacement confers upon the thermostable polypeptide substrate specificities and some kinetic parameters similar to the SLOW protein. The same replacement substitution within the third coding exon also appears to alter the ADH protein concentration to a level similar to the SLOW polypeptide and the probable effect is at the level of mRNA concentration. The low level of nucleotide sequence variation, other than that leading to the amino acid substitution, suggests a recent origin for the thermostable allele. The time since divergence of theFChD sequence fromFast is estimated to be approximately 260,000–470,000 years.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02138374
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  • 9
    Electronic Resource
    Electronic Resource
    Localized synthesis of specific proteins during oogenesis and early embryogenesis inDrosophila melanogaster (1979)
    Springer
    Development genes and evolution 187 (1979), S. 151-165 
    Details
    ISSN: 1432-041X
    Keywords: Oogenesis ; Embryogenesis ; Two-dimensional gels ; Protein synthesis ; Drosophila melanogaster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Protein synthesis in egg follicles and blastoderm embryos ofDrosophila melanogaster has been studied by means of two-dimensional gel electrophoresis. Up to 400 polypeptide spots have been resolved on autoradiographs. Stage 10 follicles (for stages see King, 1970) were labelled in vitro for 10 to 60 min with35S-methionine and cut with tungsten needles into an anterior fragment containing the nurse cells and a posterior fragment containing the oocyte and follicle cells. The nurse cells were found to synthesize a complex pattern of proteins. At least two proteins were detected only in nurse cells but not in the oocyte even after a one hour labelling period. Nurse cells isolated from stages 9, 10 and 12 follicles were shown to synthesize stage specific patterns of proteins. Several proteins are synthesized in posterior fragments of stage 10 follicles but not in anterior fragments. These proteins are only found in follicle cells. No oocyte specific proteins have been detected. Striking differences between the protein patterns of anterior and posterior fragments persist until the nurse cells degenerate. In mature stage 14 follicles, labelled in vivo, no significant differences in the protein patterns of isolated anterior and posterior fragments could be detected; this may be due to technical limitations. At the blastoderm stage localized synthesis of specific proteins becomes detectable again. When blastoderm embryos, labelled in vivo, are cut with tungsten needles and the cells are isolated from anterior and posterior halves, differences become apparent. The pole cells located at the posterior pole are highly active in protein synthesis and contribute several specific proteins which are found exclusively in the posterior region of the embryo. In this study synthesis of specific proteins could only be demonstrated at those developmental stages which are characterized by the presence of different cell types within the egg chamber, while no differences were detected when stage 14 follicles were cut and anterior and posterior fragments analyzed separately. The differences in the pattern of protein synthesis by pole cells and blastoderm cells indicate that even the earliest stages of determination are reflected by marked changes at the biochemical level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848268
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  • 10
    Electronic Resource
    Electronic Resource
    Further studies onengrailed mutants inDrosophila melanogaster (1985)
    Springer
    Development genes and evolution 194 (1985), S. 236-246 
    Details
    ISSN: 1432-041X
    Keywords: Drosophila melanogaster ; engrailed ; Selector gene ; Genetic complementation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary In 1975, Morata and Lawrence proposed that theengrailed (en) locus was a selector gene that controlled the different pathways of development followed by anterior and posterior compartments. This hypothesis assumed that the phenotype ofen 1 flies results from partial inactivity of theen + product. However, the mutant phenotype ofen 1/DF(2R)en − is weaker thanen 1/en 1. This implies that the partial P→A transformation ofen 1 does not result primarily from reduction inen + activity. Heterozygotes betweenl(2) en alleles andDf(2R)en − deletions express a similar phenotype of fused embryonic segments to that described by Nüsslein-Volhard and Wieschaus, and also by Kornberg, forl(2) en homozygoes. By this criterion, the lethal phenotype results from partial or complete lack ofen _ activity. Despite this, the1(2) en alleles give only a weak P→A transformation, whether recovered as embryonic lethals or by failure to complementen 1. They appear to define only one locus and, with the exception ofen 1, the available genetic date suggest that the complementation pattern at this locus is simple. Thus, it is unlikely thatengrailed is the sole determinant of the A/P compartment separation. It might be one of a number of loci that affect the alternative pathways followed by anterior and posterior compartments.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00848252
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