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Therapeutic cancer vaccine survives biotech bust (2015)

Ledford, Heidi

Springer Nature

In: Nature. 2015; 519(7541): 17-18. Published 2015 Feb 26. doi: 10.1038/nature.2015.16990.

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Publikationsdatum: 2015-02-26

Print ISSN: 0028-0836

Digitale ISSN: 1476-4687

Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik

Publiziert von Springer Nature

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AVIA v2.0: annotation, visualization and impact analysis of genomic variants and genes (2015)

Vuong, H., Che, A., Ravichandran, S., Luke, B. T., Collins, J. R., Mudunuri, U. S.

Oxford University Press

In: Bioinformatics

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Publikationsdatum: 2015-08-08

Beschreibung: : As sequencing becomes cheaper and more widely available, there is a greater need to quickly and effectively analyze large-scale genomic data. While the functionality of AVIA v1.0, whose implementation was based on ANNOVAR, was comparable with other annotation web servers, AVIA v2.0 represents an enhanced web-based server that extends genomic annotations to cell-specific transcripts and protein-level functional annotations. With AVIA’s improved interface, users can better visualize their data, perform comprehensive searches and categorize both coding and non-coding variants. Availability and implementation : AVIA is freely available through the web at http://avia.abcc.ncifcrf.gov . Contact : Hue.Vuong@fnlcr.nih.gov Supplementary information: Supplementary data are available at Bioinformatics online.

Print ISSN: 1367-4803

Digitale ISSN: 1460-2059

Thema: Biologie , Informatik , Medizin

Publiziert von Oxford University Press

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3

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MultiMeta: an R package for meta-analyzing multi-phenotype genome-wide association studies (2015)

Vuckovic, D., Gasparini, P., Soranzo, N., Iotchkova, V.

Oxford University Press

In: Bioinformatics

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Publikationsdatum: 2015-08-08

Beschreibung: : As new methods for multivariate analysis of genome wide association studies become available, it is important to be able to combine results from different cohorts in a meta-analysis. The R package MultiMeta provides an implementation of the inverse-variance-based method for meta-analysis, generalized to an n -dimensional setting. Availability and implementation: The R package MultiMeta can be downloaded from CRAN. Contact: dragana.vuckovic@burlo.trieste.it ; vi1@sanger.ac.uk Supplementary information: Supplementary data are available at Bioinformatics online.

Print ISSN: 1367-4803

Digitale ISSN: 1460-2059

Thema: Biologie , Informatik , Medizin

Publiziert von Oxford University Press

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Bacterial physiology: Hip persisters (2015)

Cláudio Nunes-Alves

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2015-08-15

Beschreibung: Nature Reviews Microbiology 13, 526 (2015). doi:10.1038/nrmicro3538 Author: Cláudio Nunes-Alves Persisters are dormant bacterial populations that contribute to multidrug tolerance (MDT) because they are able to escape treatment with most antibiotics, which target metabolically active cells. A new study now characterizes the molecular basis for persister generation involving HipA, a kinase that inhibits protein synthesis

Print ISSN: 1740-1526

Digitale ISSN: 1740-1534

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Unveiling the pathogen behind the vacuole (2015)

Peter Liehl; Vanessa Zuzarte-Luis; Maria M. Mota

Springer Nature

In: Nature Reviews Microbiology

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Publikationsdatum: 2015-08-15

Beschreibung: Nature Reviews Microbiology 13, 589 (2015). doi:10.1038/nrmicro3504 Authors: Peter Liehl, Vanessa Zuzarte-Luis & Maria M. Mota Many clinically relevant pathogens, including certain bacteria and protozoan parasites, have developed an intracellular lifestyle that enables them to nestle in customized vacuoles. Although these pathogens are protected from extracellular defences, recent findings indicate that host cells have evolved multiple strategies to unmask the pathogen

Print ISSN: 1740-1526

Digitale ISSN: 1740-1534

Thema: Biologie , Medizin

Publiziert von Springer Nature

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Spectral flow, crossing forms and homoclinics of Hamiltonian systems (2015)

Waterstraat, N.

Oxford University Press

In: Proceedings of the London Mathematical Society

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Publikationsdatum: 2015-08-05

Beschreibung: We prove a spectral flow formula for one-parameter families of Hamiltonian systems under homoclinic boundary conditions, which relates the spectral flow to the relative Maslov index of a pair of curves of Lagrangians induced by the stable and unstable subspaces, respectively. Finally, we deduce sufficient conditions for bifurcation of homoclinic trajectories of one-parameter families of non-autonomous Hamiltonian vector fields.

Print ISSN: 0024-6115

Digitale ISSN: 1460-244X

Thema: Mathematik

Publiziert von Oxford University Press

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The Schur-Horn problem for normal operators (2015)

Kennedy, M., Skoufranis, P.

Oxford University Press

In: Proceedings of the London Mathematical Society

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Publikationsdatum: 2015-08-05

Beschreibung: We consider the Schur–Horn problem for normal operators in von Neumann algebras, which is the problem of characterizing the possible diagonal values of a given normal operator based on its spectral data. For normal matrices, this problem is well known to be extremely difficult, and in fact, it remains open for matrices of size greater than $3$ . We show that the infinite-dimensional version of this problem is more tractable, and establish approximate solutions for normal operators in von Neumann factors of type I $_\infty$ , II, and III. A key result is an approximation theorem that can be seen as an approximate multivariate analogue of Kadison's Carpenter Theorem.

Print ISSN: 0024-6115

Digitale ISSN: 1460-244X

Thema: Mathematik

Publiziert von Oxford University Press

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8

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Asymptotic h-expansiveness rate of C{infty} maps (2015)

Burguet, D., Liao, G., Yang, J.

Oxford University Press

In: Proceedings of the London Mathematical Society

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Publikationsdatum: 2015-08-05

Beschreibung: We study the rate of convergence to zero of the tail entropy of $C^\infty$ maps. We give an upper bound of this rate in terms of the growth in $k$ of the derivative of order $k$ and give examples showing the optimality of the established rate of convergence. We also consider the case of multimodal maps of the interval. Finally, we prove that homoclinic tangencies give rise to $C^r$ $(r\geqslant 2)$ robustly non- $h$ -expansive dynamical systems.

Print ISSN: 0024-6115

Digitale ISSN: 1460-244X

Thema: Mathematik

Publiziert von Oxford University Press

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9

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Symmetric quiver Hecke algebras and R-matrices of quantum affine algebras III (2015)

Kang, S.-J., Kashiwara, M., Kim, M., Oh, S.-j.

Oxford University Press

In: Proceedings of the London Mathematical Society

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Publikationsdatum: 2015-08-05

Beschreibung: Let ${{\mathscr {C}}}^0_{{{\mathfrak {g}}}}$ be the category of finite-dimensional integrable modules over the quantum affine algebra $U_{q}'({{\mathfrak {g}}})$ and let $R^{A_\infty }{\mbox {-}\mathrm {gmod}}$ denote the category of finite-dimensional graded modules over the quiver Hecke algebra of type $A_{\infty }$ . In this paper, we investigate the relationship between the categories ${{\mathscr {C}}}^0_{A_{N-1}^{(1)}}$ and ${{\mathscr {C}}}^0_{A_{N-1}^{(2)}}$ by constructing the generalized quantum affine Schur–Weyl duality functors ${\mathcal {F}}^{(t)}$ from $R^{A_\infty }{\mbox {-}\mathrm {gmod}}$ to ${{\mathscr {C}}}^0_{A_{N-1}^{(t)}}\ (t=1,2)$ .

Print ISSN: 0024-6115

Digitale ISSN: 1460-244X

Thema: Mathematik

Publiziert von Oxford University Press

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Darmon points on elliptic curves over number fields of arbitrary signature (2015)

Guitart, X., Masdeu, M., Sengun, M. H.

Oxford University Press

In: Proceedings of the London Mathematical Society

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Publikationsdatum: 2015-08-05

Beschreibung: We present new constructions of complex and $p$ -adic Darmon points on elliptic curves over base fields of arbitrary signature. We conjecture that these points are global and present numerical evidence to support our conjecture.

Print ISSN: 0024-6115

Digitale ISSN: 1460-244X

Thema: Mathematik

Publiziert von Oxford University Press

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