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  • 1995-1999  (72.282)
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  • 1955  (10.607)
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  • 1995-1999  (72.282)
  • 1990-1994
  • 1965-1969  (27.018)
  • 1955-1959  (10.607)
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 333-345 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract This paper is a sequel to a paper by the author entitled “Restricted Transition Probabilities and Their Applications to Some Problems in the Dynamics of Biological Populations” (Bull. Math. Biophysics, 1966,28, 315–331). The paper is divided into two parts. In part one some aspects of the maximum size attained by the population during a finite time interval are studied for the case the stochastic process underlying the evolution of the population is a birth process. Two interesting by-products emerge from the study presented in part one; namely a combinatorial method of finding solutions to the Kolmogorov differential equations in special cases, and secondly, a set of criteria for the optimum allocation of genotypes in the host population of a host-pathogen system. The optimum allocation of genotypes in the host population is a problem of practical importance in controlling plant pathogens. In part two the theory of restricted transition probabilities developed in the companion paper is applied in finding the distribution of the time to the appearance of the first mutation for the case of a two dimensional birth process. The distribution of the time to the appearance of the first mutation is of importance in understanding the role mutation plays in the evolution of a population, particularly in the pathogen population of a host-pathogen system.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 355-362 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The complex arrangement of the muscle fibers in the ventricular wall and the nonsymmetric contraction and expansion of the ventricle preclude the writing of a differential equation of motion for the ventricle as a whole. We can, however, describe the motion of the ventricle by describing the motion of the dimensional parameters length and diameter; the radius, circumference, cross-sectional area, and volume following naturally from these. The ventricle is assumed to be an ellipsoid of revolution and the dimensional parameters to be periodic functions of time. Each of the parameters is expressed as a Fourier series.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 347-354 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Le modèle de Nelson peut-être considéré comme une approximation du modèle de Hodgkin-Huxley. Moins précis, il est plus maniable. Le modèle de Nelson peut également être considéré comme une généralisation du modèle de Hodgkin-Huxley. En effet, il introduit des liaisons synaptiques localisées ou diffusantes, et un processus de facilitation. Le mécanisme des liaisons synaptiques ne se traduit pas facilement dans le langage de Hodgkin-Huxley. Par contre, le processus de facilitation s'interprète facilement. Nelson's model can be taken as an approximation of Hodgkin-Huxley's model. Its precision is lesser, but it is more usable. Nelson's model can also be taken as a generalization of Hodgkin-Huxley's one; for it introduces localized or diffusing synaptic connexions and a facilitating process. The mechanism of synaptic connexions cannot be easily translated into Hodgkin-Huxley's language. On the contrary, the facilitating process is easily interpreted.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 363-370 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A spherical model for the human left ventricle with two different types of aneurysms, circular and rectangular-square, is proposed and meaningful relations are derived between the parameters of the aneurysms and ventricle. Such ventricular parameters as stroke volume, end-diastolic volume, and end-systolic volume are given normal human values to compute values for end-systolic radius and percentage shortening of muscle for various sized circular and rectangular-square aneurysms.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 375-378 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The Volterra theory of two competing populations is extended to the contemporary social problem of crime control. Domains of stability for the time dependence of the numbers in the criminal and enforcement groups are exposed by a numerical example. Both augmentation and reduction of enforcement can produce a stable system. Average values of the ratio of members in each group show great sensitivity to the control policies adopted by the remaining sector of the total population.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 379-390 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The paper deals with interactions of substances via an enzymatic reaction (Bull. Math. Biophysics,25, 141–154, 1963). The substances are the activators, inhibitors and/or substrates of the reaction. Due to the bimolecularity of the processes in the reaction, the quantitative relation between the steady state amount of complexes and the amounts of the substances assumes a typical form. In multiple enzymatic reactions this form is more complicated, though basically similar. Because the substances may influence the steady state amounts of the complexes in opposite directions, the compensation and blocking effects are the properties of enzymatic reactions. The substances with the same direction of influence may potentiate each other. In the enzymatic reaction here considered, the potentiation is always non-negative.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 391-409 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Growth-rate functions in analytic form have been obtained for cell cultures in which the doubling times follow the Gaussian and Poisson distributions. The growth-rate functions are calculated by using Laplace transforms to solve an integral equation previously presented. Oscillatory solutions result if a substantial fraction of the cells in a culture are synchronized to divide at some particular time. The synchrony and, hence, the oscillatory character of the growth-rate function eventually disappear because of the non-zero variance of the doubling-time distribution. If their variances are sufficiently small, the Gaussian and Poisson doubling-time distributions lead to growth-rate functions that become identical in the limit of large time.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 411-416 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract IfN(t) is the expected number of cells in a culture at timet, $$\dot N(t)$$ the corresponding time derivative, andf(t−τ)dt the probability that a cell of aget−τ at timet will divide in the succeeding time intervaldt, then according to Hirsch and Engelberg (this issue) there obtains the integral equation $$\dot N(t) = 2\int_{ - \infty }^t {f(t - \tau )\dot N(\tau )d\tau }$$ for describing the dynamics of the cell population. It is the purpose of this note to give two alternative derivations of this equation, one based on the age density equation of Von Foerster, and the other based on a generalized form of the Harris-Bellman equation describing the first moment of an age dependent, branching process. In addition, a probability model is posed from which the Von Foerster equation and, hence, the Hirsch-Engelberg equation readily follows.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 417-432 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A model of the dissolution kinetics of powdered enamel is developed based on the kinetic rate termq, $$q = K'H - k'C \cdot P_1$$ , whereH=[H +],C=[Ca ++] andP 1=[HPO 4 = ]. The differential equations describing the rate of mineral dissolution (and the linearly related rate of appearance of calcium and phosphate in solution) have been derived and solved for three basic cases: (1) when thepH of the solution and surface area of the enamel are considered constant, (2) when thepH is assumed constant, but the reduction in surface area during dissolution is considered, and (3) when the rise ofpH resulting from the buffering effect of the dissolved enamel is considered along with the change in surface area. Analytical solutions have been obtained for cases (1) and (2), while a numerical solution has been found for case (3). Data from a study on enamel dissolution are presented that agree with the theory of case (3), and it is noted that apH rise as large as 0.5 can occur, as has been shown elsewhere in the literature.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 477-481 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract On the basis of Landahl's theory of two-choice learning it is shown that application of punishment for wrong responses, without giving award for correct ones, does not lead to complete learning, no matter how many trials are used. If initially a “wrong response” was learned, then an attempt to inhibit it by punishment alone will in a class of cases lead only to a 50% suppression of that wrong response. Possible connection with the problem of effectiveness of punishment as a deterrent for crime is mentioned.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 483-483 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 483-483 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 13
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 485-485 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 14
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 501-510 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A set of characteristic parameters is given for electrophoresis accompanied by diffusion, followed by a method of simplification of the transport equation. The concept of electrophoretic similarity is introduced in connection with the presentation of solutions and the final section contains some dimensional considerations of the potential equation.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 511-517 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We show that when we represent (ℓ, ℛ)-systems with fixed genome as automata (sequential machines), we get automata with output-dependent states. This yields a short proof that ((ℓ, ℛ)-systems from a subcategory of automata—and with more homomorphisms than previously exhibited. We show how ((ℓ, ℛ)-systems with variable genetic structure may be represented as automata and use this embedding to set up a larger subcategory of the category of automata. An analogy with dynamical systems is briefly discussed. This paper presents a formal exploration and extension of some of the ideas presented by Rosen (Bull. Math. Biophyss,26, 103–111, 1964;28, 141–148;28 149–151). We refer the reader to these papers, and references cited therein, for a discussion of the relevance of this material to relational biology.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 487-500 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A two-dimensional nonlinear integro-differential equation with time-varying coefficients describing the behavior of the fluttering wing-body systems typical of natural flight mechanisms has been deduced from the Navier-Stokes equation which generalizes local pressure and velocity distributions in the externally oscillating air field. The resulting equation for the wing forces is combined with an analogous expression for the forces of gravitation and acceleration associated with the body. The air acceleration force, not previously considered in bio-physical models of insect and bird flight, is shown to arise from a formal analysis of unsteady or time-varying contributions to the velocity field, while the square form of the conventional steady state aerodynamic forces is derived from the intertial terms in the Navier-Stokes equation with the aid of the approximations of Newtonian impact theory. Previous calculations (Houghton, 1964) have indicated that the contribution to gravitational stability of air acceleration and aerodynamic life are roughly in the ratio of 3:1.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 17
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 519-536 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Certain types of cortical electrical events are non-propagated so that the associated electric fields must have standing wave characteristics. However, cortical electric events typically are generated by neurone populations which cannot be activated simultaneously on impulse driving. Hence the sum of the standing wave fields due to asynchronous activation of adjoining regions of cortical neurones must give the appearance of a traveling wave. Analysis of cortical waveforms is further complicated by curvature in cortical surfaces. A model is presented that shows the effects of curvature and time lag in activation on the form of the potential at points in space around a laminar array of elements simulating a population of cortical neurones. The results are compared with waveforms evoked by single-shock stimulation of the prepyriform cortex in cats.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 18
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 545-554 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A continuity equation for cell-number density in a population of cells is derived, and a system of equations for eliminating parameters between the general solution and the initial distribution obtained.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 19
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 537-544 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Use of an electrical model of the left ventricle of the heart and the arterial system permits analysis of the changes which take place as the capacity of the myocardium for generation of force decreases. The model is simple in structure, and its construction and practical testing would not be difficult. It demonstrates that, as the heart muscle weakens, the peak of intracardiac force occurs later in systole, and the difference between the intracardiac pressure and the aortic pressure in the second half of systole is much greater than for the normal heart. The feedback mechanisms which are proposed to affect myocardial contractility would affect this compensation for cardiac weakening. Indices to categorize the behavior of the normal, compensated though weakened, and decompensated myocardium are proposed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 20
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 555-566 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The frequency distribution in a population of cells of the quantityCD (defined as the amount of some chromosomal substance in a cell which containsC chromosomes) is calculated using the distribution in the population of the amount per chromosome,D, and the distribution of chromosome number,C.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 21
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 567-574 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The rate of chromosomal DNA synthesis in an exponentially growing population of cells having chromosome-number dispersion is calculated using DNA histogram data, chromosome-number distribution data, and the assumptions that the synthesis rate is constant and DNA double exactly.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 22
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 575-584 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract An estimate is made of the rate coefficient for linear DNA synthesis with exact doubling in an exponentially growing population of Ehrlich ascites tumor cells having chromosome-number dispersion. Comparison of calculated and experimental results suggest that the assumptions used in the calculation are tenable, but further experimental evidence is needed to prove this.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 23
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 655-661 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The paper develops further some suggestions made previously (Bulletin of Mathematical Biophysics,28, 283–308, 1966) that certain biological phenomena may be more easily interpreted from a “sociological” point of view by considering the organism as a social aggregate of cells and a cell as a social aggregate of genes. In this light the problems of origin of life on earth, of aging, and of parasitism and symbiosis are discussed. The notion of social aggregates of different orders is introduced.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 24
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 663-663 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 25
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A theoretical and experimental study was made of the mechanical behavior of the cornea. The theoretical analysis included an analytical solution for the symmetrical constraint of a thin, shallow, spherical shell by a rigid indenter. The experimental study investigated the rheology of the cornea with particular emphasis on its compliance with the requirements of the Boltzmann Superposition Principle. Representative results of tests on twenty enucleated hog eyes and two human eyes have been reported. The corneas of the human and hog eyes behaved as linear viscoelastic solids; the human eyes differed from the hog eyes in having a long term creep component. Several eyes were tested at the site of procurement, six to seven minutes after the animal's death, and it was established that creep is not an artifact due to aging or enucleation. The analytical and experimental results were combined to study some instruments used to detect the level of pressure in the eye. The theoretical analysis predicted that a type of elastic instability occurs during the process of flattening a small portion of the cornea; this is discussed with reference to the Goldmann and Mackay-Marg tonometers. The role of corneal creep was considered with reference to the response of the Schiøtz indentation tonometer during the time dependent process known as tonography.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 26
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 645-654 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Following previous studies, differential equations are established which determine the variation of the stimulus towards a corrective turn of the steering wheel and its effect on the excitation of the centers in the brain which results in the production of the corrective turn. The equations are derived under the highly oversimplified assumption that all excitation thresholds are so small that they can be neglected. Under these assumptions it is found that the tracking curve of a car is a sinusoid with negative damping, that is, with an ever increasing amplitude. Driving under these assumptions is imposible since the car will always eventually jump off the road. The possible effects of the threshold as well as stimuli towards corrective turns other than the distance from the edge of the lane are very briefly discussed. In spite of the negative results of the paper, its interest lies in the circumstance that with the complication of the model, we find that driving depends not only on the reaction times as the only “purely biological” parameter, but on three other neurobiophysical constants. In a subsequent paper (Rashevsky, 1967) it is shown how the introduction of one or more purely biological parameters of the driver makes a stable driving regime possible.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 27
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 663-663 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 28
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 1-20 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In the framework of the neural network theory effects similar to hypnotic displays are constructed. They are based on the associative paradigm involving non-linear interaction of excitatory and inhibitory channels with synaptic memory. The non-linearity of long-term memorizing processes may cause effects exhibited by blind spots, which are interpreted as the first stage of hypnosis. More complicated phenomena are discussed in terms of a two-layer network.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 29
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 21-61 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Mutation is introduced into autocatalytic reaction networks. The differential equations obtained are neither of repliator-type nor can they be transformed straightway into a linear equation. Examples of low dimensional dynamical systems —n=2, 3 and 4 — are discussed and complete qualitative analysis is presented. Error thresholds known from simple replication-mutation kinetics with frequency independent replication rates occur here as well. Instead of cooperative transitions or higher order phase transitions the thresholds appear here as supercritical or subcritical bifurcations being analogous to first-order phase transitions.
    Materialart: Digitale Medien
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  • 30
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 63-76 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The non-linear behavior of a differential equations-based predator-prey model, incorporating a spatial refuge protecting a consant proportion of prey and with temperature-dependent parameters chosen appropriately for a mite interaction on fruit trees, is examined using the numerical bifurcation code AUTO 86. The most significant result of this analysis is the existence of a temperature interval in which increasing the amount of refuge dynamically destabilizes the system; and on part of this interval the interaction is less likely to persist in that predator and prey minimum population densities are lower than when no refuge is available. It is also shown that increasing the amount of refuge can lead to population outbreaks due to the presence of multiple stable states. The ecological implications of a refuge are discussed with respect to the biological control of mite pests.
    Materialart: Digitale Medien
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  • 31
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 99-107 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In many applications of control theory on plant growth models biomass maximization is postulated to avoid analytically unsolvable problems while fruit maximization is commonly considered to be a more realistic criterion. In a special case, we are able to compare these criteria. Iwasa and Roughgarden (1984,Theor. Pop. Biol. 25, 78–105) have investigated a certain class of plant growth models using a fruit maximization criterion. They proved that, in the vegetative growth period, the organs follow a certain path of balanced growth. We show that this path remains optimal when biomass maximization is postulated. This underlines the importance of the balanced growth path found by Iwasa and Roughgarden. Furthermore, our result suggests that in the vegetative growth period the biomass maximization criterion is a good approximation of fruit maximization. In another theoretical control investigation, Schultzeet al. (1983,Oecologia 58, 169–177) derived a different type of balanced growth path. We apply the theory of Iwasa and Roughgarden to an improved version of the model of Schulzeet al. This leads to a new description of balanced growth between root and shoot that reflects non-linearities in the water uptake process and constitutes an interesting hypothesis for further experimental testing.
    Materialart: Digitale Medien
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  • 32
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 77-98 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In this paper the effects of changing the ion concentration in and around a sample of soft tissue are investigated. The triphasic theory developed by Laiet al. (1990,Biomechanics of Diarthrodial Joints, Vol. 1, Berlin, Springer-Verlag) is reduced to two coupled partial differential equations involving fluid ion concentration and tissue solid deformation. These equations are given in general form for Cartesian, cylindrical and spherical geometries. After solving the two equations quantities such as fluid velocity, fluid pressure, chemical potentials and chemical expansion stress may be easily calculated. In the Cartesian geometry comparison is made with the experimental and theoretical work of Myerset al. (1984,ASME J. biomech. Engng,106, 151–158). This dealt with changing the ion concentration of a salt shower on a strip of bovine articular cartilage. Results were obtained in both free swelling and isometric tension states, using an empirical formula to acount for ion induced deformation. The present theory predicts lower ion concentrations inside the tissue than this earlier work. A spherical sample of tissue subjected to a change in salt bath ion concentration is also considered. Numerical results are obtained for both hypertonic and hypotonic bathing solutions. Of particular interest is the finding that tissue may contract internally before reaching a final swollen equilibrium state or swell internally before finally contracting. By considering the relative magnitude, and also variation throughout the time course of terms in the governing equations, an even simpler system is deduced. As well as being linear the concentration equation in the new system is uncoupled. Results obtained from the linear system compare well with those from the spherical section. Thus, biological swelling situations may be modelled by a simple system of equations with the possibility, of approximate analytic solutions in certain cases.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 33
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 109-136 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Many models of immune networks have been proposed since the original work of Jerne [1974,Ann. Immun. (Inst. Pasteur) 125C, 373–389]. Recently, a limited class of models (Weisbuchet al., 1990,J. theor. Biol. 146, 483–499) have been shown to maintain immunological memory by idiotypic network interactions. We examine generalizations of these models when the networks are both large and highly connected to study their memory capacity, i.e. their ability to account for immunization to a large number of random antigens. Our calculations show that in these minimal models, random connectivities with continuously distributed affinities reduce the memory capacity to essentially nil.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 34
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 137-156 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A kinetic model is proposed to delineate the factors that determine the coronary reactive hyperemic response (RHR) to transient ischemia. The model comprises of myocardial-interstitial (M) and vascular (V) compartments. Vasodilator metabolites (VM) are produced in the M compartment during the interval of coronary occlusion. The rate of VM production is dependent on the flow rate during the ischemic period, the ratio of excess flow above the control level (R) to the loss of flow during occlusion period (D), the amount of oxygen stored and the degree of vasodilation in the V compartment prior to occlusion. Following a complete release of occlusion, VM are transported from the M to V compartment and are washed out or degraded with time. The time course of RHR is determined by the coronary patency which is proportional to VM concentration in the V compartment. Based on a set of numerical constants, the model is tested by simulating RHR to the various occlusion manoeuvres: a pair of 10 sec occlusions separated by brief release, a 15 sec release followed by a second brief occlusion, a brief release of an occlusion followed by restriced inflow and a period of restricted inflow after occlusion. The simulated results fit the experimental R/D and RH durations data of canine hearts. Factors that determine the impairment of RH capacity in coronary stenosis are suggested in terms of the model scheme.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 35
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In the present paper a kinetic study is made of the behaviour of a Michaelis-Menten enzyme-catalysed reaction in the presence of irreversible inhibitors rendered unstable in the medium by their reaction with the product of enzymatic catalysis. A general mechanism involving competitive, non-competitive, uncompetitive and mixed irreversible inhibition with one or two steps has been analysed. The differential equation that describes the kinetics of the reaction is non-linear and computer simulations of its dynamic behaviour are presented. The results obtained show that the systems studied here present kinetic co-operativity for a target enzyme that follows the simple Michaelis-Menten mechanism in its action on the substrate, except in the case of an uncompetitive-type inhibitor.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 36
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 169-173 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 37
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 191-203 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The relative contributions of mitochondrial β-oxidation and peroxisomal β-oxidation and peroxisomal ω-oxidation to the oxidation of a given fatty acidin vivo can be quantitated by an isotopic method. The approach requires infusion of a fatty acid labelled on two specific carbon atoms (e.g. [1-14C] and [11-14C] palmitate) to an isotopic steady state, with subsequent isolation and degradation of an acetylated conjugate as a product of the liver cytosolic acetyl CoA pool and of ketone bodies as a product of the liver mitochondrial acetyl CoA pool.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 38
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 229-246 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Pancreatic β-cells in intact islets of Langerhans perfused with various glucose concentrations exhibit periodic bursting electrical activity (BEA) consisting of active and silent phases. The fraction of the time spent in the active phase is called the plateau fraction and appears to be strongly correlated with the rate of release of insulin from islets as glucose concentration is varied. Here this correlation is quantified and a theoretical development is presented in detail. Experimental rates of insulin release are correlated with “effective” plateau fractions over a range of glucose concentrations. There are a number of different models for BEA in pancreatic β-cells and a method is developed here to quantify the dependence of a glucose dependent parameter on glucose concentration. As an example, the plateau fractions computed from the Sherman-Rinzel-Keizer model are matched with experimental plateau fractions to obtain a relationship between the model's glucose-dependent parameter, β, and glucose concentration. Knowledge of the relationships between β and glucose concentration and between experimental measurements of rates of insulin release and plateau fractions permits the determination of theoretical rates of insulin release from the model.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 39
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 299-344 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract When a suspension of bacterial cells of the speciesBacillus subtilis is placed in a chamber with its upper surface open to the atmosphere complex bioconvection patterns are observed. These arise because the cells: (1) are denser than water; and (2) usually swim upwards, so that the density of an initially uniform suspension becomes greater at the top than the bottom. When the vertical density gradient becomes large enough, an overturning instability occurs which ultimately evolves into the observed patterns. The reason that the cells swim upwards is that they are aerotactic, i.e. they swim up gradients of oxygen, and they consume oxygen. These properties are incorporated in conservation equations for the cell (N) and oxygen (C) concentrations, and these are solved in the pre-instability phase of development whenN andC depend only on the vertical coordinate and time. Numerical results are obtained for both shallow- and deep-layer chambers, which are intrinsically different and require different mathematical and numerical treatments. It is found that, for both shallow and deep chambers, a thin boundary layer, densely packed with cells, forms near the surface. Beneath this layer the suspension becomes severely depleted of cells. Furthermore, in the deep chamber cases, a discontinuity in the cell concentration arises between this cell-depleted region and a cell-rich region further below, where no significant oxygen concentration gradients develop before the oxygen is fully consumed. The results obtained from the model are in good qualitative agreement with the experimental observations.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 40
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 413-439 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We describe a classification scheme for bursting oscillations which encompasses many of those found in the literature on bursting in excitable media. This is an extension of the scheme of Rinzel (inMathematical Topics in Population Biology, Springer, Berlin, 1987), put in the context of a sequence of horizontal cuts through a two-parameter bifurcation diagram. We use this to describe the phenomenological character of different types of bursting, addressing the issue of how well the bursting can be characterized given the limited amount of information often available in experimental settings.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 41
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 499-506 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 461-486 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract To ensure its sustained growth, a tumour may secrete chemical compounds which cause neighbouring capillaries to form sprouts which then migrate towards it, furnishing the tumour with an increased supply of nutrients. In this paper a mathematical model is presented which describes the migration of capillary sprouts in response to a chemoattractant field set up by a tumour-released angiogenic factor, sometimes termed a tumour angiogenesis factor (TAF). The resulting model admits travelling wave solutions which correspond either to successful neovascularization of the tumour or failure of the tumour to secure a vascular network, and which exhibit many of the characteristic features of angiogenesis. For example, the increasing speed of the vascular front, and the evolution of an increasingly developed vascular network behind the leading capillary tip front (the brush-border effect) are both discernible from the numerical simulations. Through the development and analysis of a simplified caricature model, valuable insight is gained into how the balance between chemotaxis, tip proliferation and tip death affects the tumour's ability to induce a vascular response from neighbouring blood vessels. In particular, it is possible to define the success of angiogenesis in terms of known parameters, thereby providing a potential framework for assessing the viability of tumour neovascularization in terms of measurable quantities.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 43
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 14 (1995), S. 57-67 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The paper presents a simple method for solving the optimal (LQG) control problem on an infinite time horizon for linear plants described by proper rational transfer function matrices. Since the class of proper plants discussed in the paper is more general than the one commonly used, additional properties of solutions are presented. Two numerical examples illustrate the theoretical considerations. The examples have been performed on an IBM PC using the proposed algorithm. This algorithm is a part of a public ASMCS package developed by the author for analysis, synthesis, and simulations of multi-input, multi-output (MIMO) control systems.
    Materialart: Digitale Medien
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  • 44
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 14 (1995), S. 135-143 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract We study the behavior of a Hilbert network (i.e., a finite or countably infinite network whose variables are in a Hilbert space and in which the associated total energy is finite) whose elements are affected by perturbations. More specifically, we will give estimates for a change of the current distribution caused by (a) perturbations of the elements of the nominal network when the voltage sources are fixed, and (b) a change of voltage sources in a network whose elements are perturbed. The conditions given in our theorems imply insensitivity and robust stability of the nominal network. The applications of the results are illustrated by an example of an infinite network.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 45
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 14 (1995), S. 473-494 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A new lattice filter structure to model two-dimensional (2-D) autoregressive (AR) fields is proposed. The proposed structure utilizes and extracts the information contained in the backward prediction error fields and their delayed versions. The main idea is to use two sets of reflection coefficients corresponding to two quadrant filters and to increase the number of reflection coefficients with the order of the lattice filter. Increasing the number of reflection coefficients at each stage produces a sufficient number of independent parameters to model AR fields up to order three, which is an improvement over the existing 2-D lattice filter structures. The improvement is confirmed by computer simulations. In addition, a relationship between the reflection coefficients and the AR coefficients is derived. It is also shown that the entropy contained in the backward prediction error field vector of the proposed structure is closer to the input entropy when compared to those contained in existing 2-D lattice filters.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 46
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 14 (1995), S. 555-561 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper addresses the problem of global asymptotic stability in recursive first hyperquadrant causalm-D digital filters. A set of simple-to-check 1-D conditions necessary for stability of them-D system is given. Generalizations tov-dimensional (v〈m) subsystems are also provided. These derived conditions are useful in determining asymptotic convergence ofm-D digital filters implemented in fixed or floating point arithmetic. The set of 1-D conditions can be considered the analogous result to practical bounded input bounded output (BIBO) stability for linearm-D systems.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 47
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 14 (1995), S. 633-637 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A new efficient algorithm for calculating the weighting coefficients of maximally linear, FIR digital differentiators is presented. Simple closed-form explicit and recursive formulas are derived in a very straightforward manner. Moreover, a simple recursive equation is established, relating coefficients of two digital differentiators of adjacent ranks.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 48
    Digitale Medien
    Digitale Medien
    Springer
    Circuits, systems and signal processing 14 (1995), S. 661-667 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper presents a sequence of pseudorandom arrays with triangular symmetry. The sequence of arrays is also pseudorandom in nature, so it can be called a pseudorandom sequence of arrays, or PRSA. A circuit for the PRSA generator is given and some interesting properties of this type of PRSA are discussed. Also, some of the concepts presented in this paper are clarified with an example.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 49
    Digitale Medien
    Digitale Medien
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    The journal of Fourier analysis and applications 2 (1995), S. 29-48 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We investigate the $L_p$ -error of approximation to a function $f\in L_p({\Bbb T}^d)$ by a linear combination $\sum_{k}c_ke_k$ of $n$ exponentials $e_k(x):= e^{i\langle k,x\rangle}=e^{i(k_1x_1+\cdots+k_dx_d)}$ on ${\Bbb T}^d,$ where the frequencies $k\in {\Bbb Z}^d$ are allowed to depend on $f.$ We bound this error in terms of the smoothness and other properties of $f$ and show that our bounds are best possible in the sense of approximation of certain classes of functions.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 50
    Digitale Medien
    Digitale Medien
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    The journal of Fourier analysis and applications 2 (1995), S. 237-259 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract Let $L[\,\cdot\,]$ be a nondivergent linear second-order uniformly elliptic partial differential operator defined on functions with domain $\Omega.$ Consider the question, "When is a function u a solution of $L[u] = 0$ on $\Omega$ ?" The naive answer, "u is a solution of $L[u] = 0$ on $\Omega$ if $u\in C^2(\Omega)$ and $L[u](x) = 0$ for all $x\in\Omega,$ " is clearly too limited. Indeed, if the coefficients of L are in $W^{1,2}\cap L^{\infty},$ then L can be rewritten in divergence form for which the notion of a "weak" solution can be applied. In this case there could be infinitely many functions that are "weak" but not classical solutions. More importantly, even if the coefficients of L are just bounded and measurable, the recent results of Krylov permit us to construct "solutions" of $L[u] = 0$ on $\Omega,$ and these "solutions" are generally no better than continuous; the "weak" solutions previously mentioned can be obtained by this construction, too. The preceding discussion provides us with an adequate extrinsic definition of solution (i.e., given a function u we either prove that it is or is not the result of such a construction) that has been used by several authors, but one that is not particularly satisfying or illuminating. Our major contribution in this paper is to show the following. I. There is an intrinsic definition of solution that is equivalent to the extrinsic one. II. Furthermore, the intrinsic definition is just the (now) well-known Crandall-Lions viscosity solution, modified in a natural way to accommodate measurable coefficients.
    Materialart: Digitale Medien
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  • 51
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    Digitale Medien
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    The journal of Fourier analysis and applications 2 (1995), S. 397-406 
    ISSN: 1531-5851
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Mathematik
    Notizen: Abstract We prove a Tauberian theorem of the form $\phi * g (x)\sim p(x)w(x)$ as $x \to \infty,$ where p(x) is a bounded periodic function and w(x) is a weighted function of power growth. It can be used to study the weighted average of the form $(T^\alpha (\hbox {ln }T)^\beta)^{-1}\int _0^T h(t) \, dt.$
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 52
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 1-16 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper, we present a new class of two-dimensional FIR-median hybrid (FMH) filters, which we call separable FMH filters, for image noise smoothing. In a separable FMH filter, a one-dimensional FMH filter is applied to the rows and the columns of an image successively. The deterministic properties of separable and cross window FMH filters are discussed. Under certain assumptions, it is proved that a root of a separable FMH filter is a root of the corresponding cross window FMH filter. The noise attenuating properties of a separable FMH filter are studied and compared with those of the separable median filter, the two-dimensional median filter with a square window, and the cross window FMH filter.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 53
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 69-85 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The Chinese remainder theorem is a fundamental technique widely employed in digital signal processing for designing fast algorithms for computing convolutions. Classically, it has two versions. One is over a ring of integers and the second is over a ring of polynomials with coefficients defined over a field. In our previous papers, we developed an extension to this well-known theorem for the case of a ring of polynomials with coefficients defined over a finite ring of integers. The objective was to generalize number-theoretictransforms, which turn out to be a special case of this extension. This paper focuses on the extension of the Chinese remainder theorem for processing complex-valued integer sequences. Once again, the present work generalizes the complex-number-theoretic transforms. The impetus for this work is provided by the occurrence of complex integer sequences in digital signal processing and the desire to process them using exact arithmetic.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 54
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 145-166 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A method to improve the stability of the forced response of a recursive digital filter with nonlinearities due to finite wordlength is presented. An analysis of applying a stability criterion on the nonlinear filter is performed by transforming the problem into a mathematical problem of finding a zero set. As a result of the mathematical analysis, one can find a maximal sector size that bounds an equivalent nonlinearity, so that stability is ensured. This sector size is influenced by the choice of the desired nonlinearity characteristic appropriate to the problem, and the amount of the input scaling needed. Another improvement of the filter's stability is obtained by adding a feedback gain, the value of which is determined by using the zero set-finding method. Simulation results showing the improved stability properties of a filter designed by this method are presented.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 55
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 285-298 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract In this paper a fully systolic, bit level, three-port unconstrained adaptor, which constitutes the main nontrivial building block of ladder wave digital filters, is generated. The one-dimensional binary convolution is used as the underlying algorithm for the implementation of a multiplication. The Isb-first input data organization approach is adopted and thecanonical mapping methodology is used to fully systolize the unconstrained parallel three-port adaptor at the bit level with piplining period a=1. The technique is based on a transformation of the adaptor's signal-flow graph, so that unidirectional data flow takes place. A ring-systolic scheme is proposed for implementing communications among adaptors.
    Materialart: Digitale Medien
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  • 56
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 317-349 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract We consider the problem of robust stochastic adaptive control of not necessarily minimum phase systems in the presence of unmodelled dynamics. Stochastic gradient algorithms with parameter projection and modified gain sequence are used for the estimation of the unknown controller parameters. Global stability of the adaptive system is achieved without requiring the strictly positive real condition and the persistency exciting condition to be satisfied.
    Materialart: Digitale Medien
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  • 57
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 427-443 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A theoretical framework for the investigation of the qualitative behavior of differential-algebraic equations (DAEs) near an equilibrium point is established. The key notion of our approach is the notion of regularity. A DAE is called regular locally around an equilibrium point if there is a unique vector field such that the solutions of the DAE and the vector field are in one-to-one correspondence in a neighborhood of this equilibrium point. Sufficient conditions for the regularity of an equilibrium point are stated. This in turn allows us to translate several local results, as formulated for vector fields, to DAEs that are regular locally around a given equilibrium point (e.g. Local Stable and Unstable Manifold Theorem, Hopf theorem). It is important that these theorems are stated in terms of the given problem and not in terms of the corresponding vector field.
    Materialart: Digitale Medien
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  • 58
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 495-524 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The classical notion of the λ-generalized nullspace, defined on a matrixA εR n×n,where λ is an eigenvalue, is extended to the case of ordered pairs of matrices(F, G), F, G ε R m×nwhere the associated pencilsF − G is right regular. It is shown that for every α εC ∪ {∞} generalized eigenvalue of (F, G), an ascending nested sequence of spaces {P α i ,i=1, 2,...} and a descending nested sequence of spaces {ie495-02 i=1, 2,...} are defined from the α-Toeplitz matrices of (F, G); the first sequence has a maximal elementM α * , the α-generalized nullspace of (F, G), which is the element of the sequence corresponding to the index τα, the α-index of annihilation of (F, G), whereas the second sequence has the first elementP α * as its maximal element, the α-prime space of (F, G). The geometric properties of the {M α i ,i=1, 2,...,τα and {P α i ,i=1, 2,...sets, as well as their interrelations are investigated and are shown to be intimately related to the existence of nested basis matrices of the nullspaces of the α-Toeplitz matrices of (F, G). These nested basis matrices characterize completely the geometry ofM α * and provide a systematic procedure for the selection of maximal length linearly independent vector chains characterizing theα-Segre characteristic of (F, G).
    Materialart: Digitale Medien
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  • 59
    Digitale Medien
    Digitale Medien
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    Circuits, systems and signal processing 14 (1995), S. 563-586 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The robustness problem of stability for large-scale uncertain systems with a class of multiple time delays is addressed in this paper. By applying the complex Lyapunov stability theorem, the matrix measure techniques, and norm inequalities, a new approach for solving a general case of the above problem is proposed. Several robust stability conditions, delay-dependent or delay-independent, are derived to guarantee the asymptotic stability and exponential stability of the uncertain large-scale time-delay systems. Moreover, these obtained results can also be applied to the stabilization design.
    Materialart: Digitale Medien
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  • 60
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    Circuits, systems and signal processing 14 (1995), S. 615-632 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Successful speech recognition is highly dependent on appropriate speech segmentation. The poor efficiency of the sequential detection of abrupt changes in the signals with relatively short stationary intervals, as is the case with speech signals, can be improved by the off-line maximum likelihood segmentation algorithm. In this paper the new segmentation algorithm is presented. For the a priori known number of segments, the algorithm determines such signal partitions for which the sum of segment distortion is minimal. The generalized maximum likelihood distortion measure has been introduced, and has proven to be particularly efficient on short signal segments. In the case of an unknown number of segments, its estimate is obtained comparing the reduction of the distortion. The asymptotic properties of the distortion sequence have been analyzed, which led to the definition of the presented segmentation algorithm. The introduced measure can be applied both to the AR and ARMA models. The segmentation algorithm is verified on test signals as well as on the natural speech signal, for which the pitch synchronous framing scheme is applied. The experimental results also include a comparison of the AR and ARMA model-based segmentations. The first results show that ARMA model-based segmentation gives somewhat better results than the AR model algorithm.
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  • 61
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    Circuits, systems and signal processing 14 (1995), S. 639-651 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract A new bit-serial architecture for implementation of high order FIR filters is introduced, as well as example FPGA and CMOS realizations. This structure exploits the simplicity of coefficients that consist of two power-of-two terms to yield efficient implementations. Quantization effects are discussed and a simple block scaling method for reducing rounding and truncation noise in high order filters is also presented.
    Materialart: Digitale Medien
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  • 62
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    Circuits, systems and signal processing 14 (1995), S. 39-55 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This paper describes an implementation of 2-D FIR and IIR linear digital filters via VLSI array processors. The underlying realization structures are based on the matrix decomposition approach. The 2-D concurrent processing is used in order to implement the row and column delays within the cycle time. A high degree of concurrency is achieved by exploiting the pipelining of the array processors with the inherent parallelism of the matrix decomposition structure. The resulting structures are modular, and regular, use only local communication and internal local feedback loops, and achieve high throughput and sampling rates.
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  • 63
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    Circuits, systems and signal processing 14 (1995), S. 111-134 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract This article studies dynamical systems under perturbations. We prove an Equilibrium Equivalence Theorem that guarantees that the dynamics of the system remains unchanged under perturbations with certain fairly general assumptions. We also prove that a power system is robust with respect to parameter changes in generic situations. Concepts of equilibrium equivalence and equilibrium equivalence structural stability are developed and are applied to studies of bifurcations of vector fields on noncompact manifolds. A constructive approach to equilibrium equivalence structural stability verification is emphasized. General results on structural stability of vector fields on differential manifolds are established and important applications of this theory to stability analysis are considered.
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  • 64
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    Circuits, systems and signal processing 14 (1995), S. 167-185 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract The problem of designing a stabilizing compensator for a control system to achieve prescribed initial value constraintsυ (i)(0+)=yi is considered. Indeed, modulo certain technical conditions, such a compensator exists if and only if yi=0;i= 0,1,...,r〈p〉 +r〈t〉 −2; wherer〈p〉 is the relative degree of the plant andr〈t〉 is the relative degree of the system input. This theorem is derived and a complete parameterization of the set of compensators that achieve the prescribed design constraints is formulated.
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  • 65
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    Circuits, systems and signal processing 14 (1995), S. 255-278 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Wideband source location in array signal processing has received much attention in the literature lately. Methods such as the Coherent Signal Subspace (CSS) method proposed by Wang and Kaveh [12], and the signal subspace method used by Cadzow [3], are typical of the approaches used to tackle the multiple wideband source location problem. Most of these methods are variations of the narrowband high-resolution methods. Grenier [5], on the other hand, has applied the idea of time-dependent Auto-Regressive (AR) modeling [7] for a nonstationary process to the frequency domain AR modeling of the sensor outputs in a linear array and has been able to produce good results for a wideband signal. The AR coefficients in the model are expanded in a set of frequency-dependent basis functions. The choice of the basis functions was deemed immaterial and the method works even when only one snapshot of the array output is available. In this paper, we re-examine this method and present an extension of the frequency-dependent AR modeling approach to a planar array. It is shown that the use of a set of sinc functions for representing the frequency-dependent AR coefficients accurately tracks their evolution in the frequency domain, and gives superior performance compared to that when power or Legendre functions are used. We also propose two methods for smoothing the spatial spectra, from which the source locations are determined. Comparison with the CSS method are also presented.
    Materialart: Digitale Medien
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  • 66
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    Circuits, systems and signal processing 14 (1995), S. 17-38 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Centralized methods for source location using sensor arrays have computational and communication burdens that increase significantly with the number of sensors in the array. Therefore, these methods may not be usable in the applications involving very large arrays. In such applications, the data processing may need to be decentralized. This paper introduces two methods for decentralized array processing, based on the recently proposed MODE algorithm. For prescribed nonoverlapping subarrays, both methods are shown to be statistically optimal in the sense that asymptotically they provide the most accurate decentralized estimates of source location parameters. The problem of subarray selection to further optimize the estimation accuracy is only briefly addressed. The two methods are intended for different types of applications: the first should be preferred when there exist significant possibilities for local processing or for parallel computation in the central processor; otherwise the second method should be preferred. The accuracy of the two decentralized methods is compared to the centralized Cramér-Rao bound, both analytically and numerically, in order to provide indications about the loss of accuracy associated with decentralized processing.
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  • 67
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    Circuits, systems and signal processing 14 (1995), S. 87-110 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract We present in this paper a recursive-in-order least-squares (LS) algorithm to compute efficiently the parameters of a 2-D Gaussian Markov random field (GMRF) model. The algorithm is based on the fact that the least-squares estimation of the parameters of a 2-D noncausal GMRF model is consistent and the coefficient matrix in the normal equation has near-to-block-Toeplitz structure. Hence, it has a Levinson-like form for the updating of model parameters by introducing auxiliary variables. Moreover, this paper proposes the concept ofrecursive path for 2-D recursive-in-order algorithms, and points out that there exists a tradeoff between fast computation of the parameters and accurate choice of model support; a compromise recursive path is then suggested where the orders change alternately in two directions. The computational complexity of the developed algorithm is analyzed, and the results show that the algorithm is more efficient when either the image size or the model support is larger. It is found that the total number of multiplications (mps) involved in the new algorithm is only about 14% of that in the conventional LS method when the image size is 512 × 512 and the neighbor set of the model is a 17 × 17 window. Computer simulation results using the recursive-in-order algorithm developed in this paper and the conventional LS method are given to verify the correctness of the new algorithm.
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  • 68
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    Circuits, systems and signal processing 14 (1995), S. 539-553 
    ISSN: 1531-5878
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Elektrotechnik, Elektronik, Nachrichtentechnik
    Notizen: Abstract Cross terms are an inherent consequence of the second order nature of Cohen's class TFDs (Time-Frequency Distributions) [5], [6]. They are manifest in a TFD of multicomponent signals as spurious artifacts arising from interactions between the various signal components, and they can often appear at times and/or frequencies inconsistent with the underlying physical nature of the signal, causing misinterpretation [2], [3], [4]. There are many time frequency distributions that avoid the cross term effect; the best are the Choi-Williams ED (Exponential Distribution) [1] and Levin's IPS (Instantaneous Power Spectrum) [9]. In this paper we combine the cross term reducing philosophy of the ED and IPS to obtain a new TFD that most effectively reduces the cross term effect. Surprisingly, the new TFD also satisfies most desired TFD properties.
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  • 69
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    Bulletin of mathematical biology 28 (1966), S. 1-10 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Résumé Les premiers étages sensoriels sont étudiés en utilisant notre modèle de neurone et en supposant que les réseaux responsables de la perception sont particulièrement solides, stables, économiques. Nous montrons que les premiers neurones doivent être spontanément périodiques et autorégulés. La nécessité fonctionnelle des premiers étages de la voie visuelle est démontrée. Par analogie, nous étudions la voie auditive.
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  • 70
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    Bulletin of mathematical biology 28 (1966), S. 11-24 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The problem of the viscous flow of an incompressible Newtonian liquid in a converging tapered tube has been solved in spherical polar coordinates. The method of the solution involves the Stokes' stream function and a technique introduced by Stokes in the study of a sphere oscillating in a fluid. The theory for the flow in a rigid tube includes: (1) the pulsatile flow with both radial and angular velocity components; (2) the steady state flow with both radial and angular velocity components and (3) the very slow steady state flow with only a radial velocity component present. For a tapered elastic tube, the velocity of the propagated pulse wave is determined. The solution given is in terms of the elastic constants of the system and the coordinates for this type of geometry. The pulse velocity is then related to the velocity in an elastic cylindrical tube with the necessary correction terms to account for the tapered tube.
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  • 71
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    Bulletin of mathematical biology 28 (1966), S. 25-50 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In this paper a class of branching processes applicable to populations reproducing by some asexual means or by a simple selfing system of mating is studied. The paper is divided into three parts. In part one the mathematical model is introduced, part two is a mathematical analysis of the model, and in part three concrete applications and examples are given. Many of the proofs of the theorems in part two are omitted but will appear in a subsequent issue of theBulletin.
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  • 72
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    Bulletin of mathematical biology 28 (1966), S. 51-74 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The application of the earlier results (Pavlidis, T. 1965. “A New Model for Simple Neural Nets and its Application in the Design of a Neural Oscillator.”Bull. Math. Biophysics,27, No. 2, 215–229) to the design of more complex neural nets is attempted. The following cases are considered: 1. Chains of neurons where it is proven that the frequency of the output pulses does not depend on the value of the input as long as it is above a certain threshold. 2. Groups of neurons with backward inhibition which present an intermittent mode of operation. 3. Neural nets with periodic facilitation which permit time sharing of certain components for different functions. 4. A neural net which can detect the sign of the input even if the main receptor is sensitive only to the absolute value of it, is presented. 5. A velocity estimating neural net which in combination with one of the nets with intermittent response provides a model for the smooth eye tracking movements.
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  • 73
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    Bulletin of mathematical biology 28 (1966), S. 75-90 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract By assigning coordinates to the information space comprising all knowledge, rigorous mathematical interpretations can be placed on such terms as academic ability, memory and creativity such that these psychometric concepts can be incorporated into a framework of functional analysis which then permits the optimization of long-term academic learning processes through the location of the teaching trajectories in information space which will maximize the knowledge accumulated in a generalized educational system composed of a complex of subject-pupil-teacher interactions. The concepts of discrete and continuous information spaces are discussed in connection with subject-subject, subjectpupil and pupil-pupil interactions, and the advantages of using variational versus dynamic programming methods of optimizing alternative educational systems are evaluated.
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  • 74
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    Bulletin of mathematical biology 28 (1966), S. 103-106 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract IfK is a partition of a setK which is partially ordered by the relationR andR is a collection of pairs of sets ofK such that the sets of each pair are related byR in the sense of Rashevsky, thenR is a relation which partially ordersK. Necessary and sufficient conditions thatK be a chain are obtained, and ifK is a chain under these conditions, it is shown thatK is unique.
    Materialart: Digitale Medien
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  • 75
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    Bulletin of mathematical biology 28 (1966), S. 161-166 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract This paper continues a comparison of the Taylor series and spherical harmonic forms of multipole representations initiated by Yeh (Bull. Math. Biophysics,24, 197–207, 1962). It is shown that while transformations from Taylor series form into spherical harmonic form is always possible, the inverse cannot be accomplished as suggested by Yeh; corrected transformation equations are given. It is also shown that direct measurement of Taylor coefficients, as outlined in Yeh, Martinek, and de Beaumont (Bull. Math. Biophysics,20, 203–216, 1958), is actually not possible. Accordingly, only the spherical harmonic coefficients can be determined by measurement of surface potentials, as in electrocardiography.
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  • 76
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    Bulletin of mathematical biology 28 (1966), S. 181-190 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract This paper is a continuation of a paper, “Some Multi-Dimensional Branching Processes as Motivated by a Class of Problems in Mathematical Genetics I,” by C. J. Mode, which appeared in a previous issue of theBulletin. Its purpose is two-fold; namely to discuss the mathematical existence of the model and to supply the mathematical proofs of some theorems in section two of the paper mentioned above. This paper should be read in conjunction with the previous paper.
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  • 77
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    Bulletin of mathematical biology 28 (1966), S. 191-194 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Rosen (Bull. Math Biophysics. 1959) has argued that a self-reproducing automaton of the type originally described by von Neumann is impossible because of a logical paradox inherent in its definition. The paradox is resolved by explicitly allowing errors (mutations) in the system and thus introducing evolution. There is no paradox in an automaton, originating from a slightly different ancestor through mutation. The von Neumann model thus becomes realistic and useful for a discussion of biological phenomena.
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  • 78
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    Bulletin of mathematical biology 28 (1966), S. 167-179 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Previously proposed formulae for the quantitative estimation of bidirectional shunts across ventricular septal defects require determination of the oxygen contents of mixed venous, pulmonary artery, pulmonary venous, and aortic blood. Because these formulae do not take into account the mixing of oxygenated with unoxygenated blood within the ventricles, their use must result in underestimation of shunt flows in each direction. A mathematical model for a ventricular defect is examined, in which it is assumed that mixing of blood occurs in each of six sites in the venae cavae or right atrium, right ventricle, pulmonary artery, left atrium, left ventricle, and aorta. A total of fourteen streams of blood can flow from one to another of these mixing sites. As long as complete mixing occurs in the six specified mixing sites, any degree of mixing or non-mixing of the various streams is permitted. From the equations characterizing the model, formulae are derived in which the shunt flow in each direction is expressed in terms of the oxygen contents in the six mixing sites and the fractions of blood which enter the shunt from either side without prior mixing in a ventricular mixing site. The previously reported formulae, which apply when no ventricular mixing is allowed to occur, lead to theoretical minimum values for the shunt flows in each direction. At the opposite extreme where all the shunting blood is required to mix in a ventricle before entering the shunt, formulae for maximum possible shunt flows are also obtained. The absolute values for the left-to-right and right-to-left shunt flows, which must lie somewhere between the theoretical maximum and minimum values, cannot be computed from blood gas data alone.
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  • 79
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    Bulletin of mathematical biology 28 (1966), S. 195-205 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Experimental evidence strongly suggests that the contractility of the intact heart in situ, in contrast to that of striated muscle elsewhere in the body, is controlled in a close-cycle system. Thus, the variation of intraventricular pressure during systole follows a complex pattern, whose relative form remains quite constant regardless of the duration of ejection. By use of the single-chambered model of the cardiovascular system, a mathematical representation of a feasible feedback mechanism is developed. The requirement that the feedback system must satisfy mathematical principles eliminates relationships apparently reasonable from a physiological viewpoint. A clinical application which the mathematical development suggests is that early arterial hypertension may arise from an abnormal feedback mechanism with excessively large cardiac output in the initial portion of systole.
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  • 80
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    Bulletin of mathematical biology 28 (1966), S. 207-216 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Due to the lack of direct X-ray evidence for base pairing being the only mechanism for the formation of double helix in a DNA crystal, an alternative explanation is suggested so that the observed DNA loop becomes essential.
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  • 81
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    Bulletin of mathematical biology 28 (1966), S. 219-233 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
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  • 82
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    Bulletin of mathematical biology 28 (1966), S. 217-218 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Validity of group ring expression of selfed population is shown for cases in which there are differences in recombination probabilities between two sexual sides of a plant.
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  • 83
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    Bulletin of mathematical biology 28 (1966), S. 261-282 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract An integral equation analysis of generaln compartment steady state systems imbedded in static media of arbitrary complexity has been developed. A set of initial entry functions can be found which serve to determine a corresponding set of partitioned initial entry functions. The partitioned functions, in turn, can be used to predict the probabilities and time courses of various transport histories and to determine all steady state rates of flow between measured compartments. The method is quite general, being completely applicable, for example, to closed systems, to cyclic systems and to systems in which relatively rapid (but finite) exchange between compartments occurs.
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  • 84
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    Bulletin of mathematical biology 28 (1966), S. 309-313 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract From the definition of a strong and weakn-ary relation betweenn sets, given in a previous paper (Bulletin of Mathematical Biophysics,27, 477–492), it follows that for a given set ofn sets and givenn-ary relationR between them there can exist only one strong relation, but a large number of weak ones. An expression for the total number of possible weak relations is derived and the notion of the degree of weakness of a relation is introduced and discussed.
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  • 85
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The problem of determining the sequence of a biopolymer from its fragments is stated in mathematical terms. Using concrete properties of a free monoid, certain general classes of biopolymers are shown to be insolvable from fragment data produced by complete digestion where enzymes specific for any possible combination of chemical bonds are employed.
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  • 86
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    Bulletin of mathematical biology 28 (1966), S. 283-308 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract To the extent that all biological phenomena are perceivable only through their physical manifestations, it may be justified to assume that all biological phenomena will be eventually represented in terms of physics; perhaps not of present day physics, but of some “extended” form of it. However, even if this should be correct, it must be kept in mind that representing individual biological phenomena in terms of physics is not the same as deducing from known physical laws the necessity of biological phenomena. Drawing an analogy from pure mathematics, it is possible that while every biological phenomenon may be represented in terms of physics, yet biological statements represent a class of “undecidable” statements within the framework of physics. Such a conjecture is reinforced by the history of physics itself and illustrated on several examples. The 19th century physicists tried in vain todeduce electromagnetic phenomena from mechanical ones. A similar situation may exist in regard to biological and social sciences. Quite generally, the possibility of representing a class B phenomena in terms of class A phenomena does not imply that the phenomena of class B can be deduced from those of class A. The consequences of the above on the relation between physics, biology, and sociology are studied. A tentative postulational formulation of basic biological principles are given and some consequences are discussed. It is pointed out that not only can the study of biological phenomena throw light on some physical phenomena, but that the study of social phenomena may be of value for the understanding of the structures and functions of living organisms. The possibility of a sort of “socionics” is indicated.
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  • 87
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    Bulletin of mathematical biology 28 (1966), S. 371-374 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract It is shown that any (ℳ ℛ) has some component which cannot be re-established after it has been inhibited. If there is only one such component, it must be central, that is, its inhibition stops the whole system. These results hold even when it is not assumed that ℳ is connected.
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  • 88
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    Bulletin of mathematical biology 28 (1966), S. 315-331 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In this paper a theory of a class of restricted transition probabilities is developed and applied to a problem in the dynamics of biological populations under the assumption that the underlying stochastic process is a continuous time parameter Markov chain with stationary transition probabilities. The paper is divided into three parts. Part one contains sufficient background from the theory of Markov processes to define restricted transition probabilities in a rigorous manner. In addition, some basic concepts in the theory of stochastic processes are interpreted from the biological point of view. Part two is concerned with the problem of finding representations for restricted transition probabilities. Finally, in part three the theory of restricted transition probabilities is applied to the problem of finding and analyzing some properties of the distribution function of the maximum size attained by the population in a finite time interval for a rather wide class of Markov processes. Some other applications of restricted transition probabilities to other problems in the dynamics of biological populations are also suggested. These applications will be discussed more fully in a companion paper.
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  • 89
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    Bulletin of mathematical biology 28 (1966), S. 433-441 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Equilibrium solubility considerations are presented based on the assumption that equating the kinetic expressionq, developed in part I, to zero can describe the equilibrium or steady state between hydroxyapatite and salt solutions. From this expression is derived Hodge's empirical equilibrium equation,C=KH. Further, a lograithmic transformation of this equation results in an expression that accounts for the equilibrium calcium, phosphorus andpH relation found by Levinskas and Neuman. Finally, it also shows the relation between log (C·P) andpH necessary for typical artificial carious lesions as found by Coolidge, Besic and Jacobs. A discussion of a recent theory of hydroxyapatite solubility of LaMer reveals calculation errors that vitiate his results. It is shown that logK 1 (K 1 is the ratio of the rate constants inq and can serve as a solubility equilibrium constant for hydroxyapatite) varies by only 1.2 units when calculated from three diverse sets of data. This variation is less than that reported by LaMer (when the errors of calculation in that work are corrected) and considerably less than the range of 11 among attempts to calculate a conventionalpK sp , as summarized by Hodge.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 90
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 465-475 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract In imitative behavior, as studied previously by N. Rashevsky (Mathematical Biology of Sociol Behavior, Chapter XIII, The University of Chicago Press, 1950), the reason for the majority of a society to accept a particular behavior is based on purely voluntary action (band-wagon effect). In the present paper effects of coercion of the majority by a small minority group which poses the means for coercion, are studied. More general types of equations are thus obtained and threshold effects found, which bear a resemblance to some such effects studied previously.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 91
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 28 (1966), S. 443-464 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract Part III attempts to develop a diffusion controlled model of caries in the intact enamel employing the kinetic results of the previous two parts. A model of the enamel as a granular bed with a diffusible organic matrix filling the interstices is considered. The basic equations of diffusion and simultaneous reaction are developed under the assumption that all the reactions are so rapid as compared with the diffusion rate, that they are in a quasi-equilibrium state. The resultant system of seven coupled, non-linear parabolic partial differential equations is of such complexity that only numerical solutions could be attempted. Stability restrictions inherent in the problem dictated the use of the DuFort-Frankel numerical solution for parabolic boundary problems. Numerical solutions giving the concentration of all reactants, the rate of mineral loss, and the enamel porosity were obtained for a variety of boundary conditions. It is found that departure from the equilibrium condition expressed in part II is necessary for the occurrence of an attack on the enamel. The rate and pattern of penetration is then determined primarily by the concentrations of undissociated buffer, and salts, together with the rate of diffusion in the surrounding medium. The possibility of a relatively intact surface layer persisting over a demineralized subsurface region due solely to the composition of the demineralizing medium is noted. Remineralization behavior in portions of the carious lesion occurs in the model under certain boundary conditions.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 92
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 205-227 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The formation of neuronal networks requires axonal growth towards target neutons. A simple set of grammar rules is introduced to describe axonal growth towards target cells situated both at short and long distances from the growing neuron. Growth for short distances is descrbed by growth following the highest gradient of a chemical compound (which is spread by diffusion from the targets). This approach fails to describe long-distance growth, which is addressed by adopting a graph grammar theory for growing trees. With these rules a flexible tool to draw network of neurons by computer can be developed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 93
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 345-366 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A pair of growth control triads are used to describe coincident tumor growth and liver regeneration after partial hepatectomy. The models are extensions of previous growth control models which describe tumor growth in an unperturbed host (Michelson and Leith, 1991,Bull. math. Biol. 53, 639–656; idem, 1992, Proceedings of the Third International Conference on Communications and Control, Vol. 2, pp. 481–490; idem, 1992,Bull. math. Biol. 55, 993–1011; idem,J. theor. Biol. 169, 327–338). The linkage between the two triads depends upon systemic signals carried by soluble factors, and mathematical descriptors based upon biological first principals are proposed. The sources of the growth factors, their targets and the processing of their signals are investigated. Analyses of equilibrium in the constant coefficients case and simulated growth curves for the dynamic system are presented, and the effects of growth factor-induced mitogenesis and angiogenesis are discussed in particular. A case is made for early and late responses in the coupled control system. The biology of the signal processing paradigm is placed within a new theoretical context and discussed with regard to tumor adaptation, liver differentiation and the development of a tumor hypoxic fraction.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 94
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 381-399 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We consider the problem of optimal stabilization and control of populations which follow the Leslie model dynamics, within state space and control systems theory and methodology. Various types of culling strategies are formulated and introduced into the Leslie model as control inputs, and their effect on global asymptotic stability is investigated. Our new approach provides answers to several unexplored problems. We show that in general it is possible to achieve a desired stable equilibrium population level, through the design of a class ofshifted-proportional stabilizing culling policies. Further, we formulate general non-linear constrained opitmization problems, for obtaining the cost-optimal policy among this generally infinite class of such stabilizing policies. The theoretical findings are illustrated through the solution of the problem over an infinite planning horizon for a numerical example. A comparative study of the costs and dynamic effects of various culling strategies also supports the mathematical results.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 95
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 593-617 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A new approach for data assimilation, which is based on the adjoint method, but allows the computer code for the adjoint to be constructed directly from the model computer code, is described. This technique is straightforward and reduces the chance of introducing errors in the construction of the adjoint code. Implementation of the technique is illustrated by applying it to a simple predator-prey model in a model fitting mode. A series of identical twin numerical experiments are used to show that this data assimilation approach can successfully recover model parameters as well as initial conditions. However, the ease with which these values are recovered is dependent on the form of the model equations as well as on the type and amount of data that are available. Additional numerical experiments show that sufficient coefficient and parameter recoveries are possible even when the assimilated data contain significant random noise. Thus, for biological systems that can be described by ecosystem models, the adjoint method represents a powerful approach for estimating values for little-known biological parameters, such as initial conditions, growth rates, and mortality rates.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 96
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The effect of group size on behavioral parameters of the Oriental hornet,Vespa orientalis, was assessed experimentally under laboratory conditions. Hornet groups of various sizes (ranging from 1 to 100 individuals per group) comprised of young individuals (0–24 hr of age) devoid of a queen were placed in artificial breeding boxes (ABBs). The following three quantitative parameters were evaluated: the amount and rate of building as a function of the number of hornets in the group, the rate of oviposition as, related to group size and the longevity of hornets as a function of their group size. The probability for the occurrence of these events was similarly considered and additional behavioral parameters were only assessed qualitatively. Results of this investigation revealed a relation between the three mentioned quantitative behavioral parameters and the number of hornets per group. The number of hornets per group was positively related to the extent of building, the number of cells built by a group is $$2\pi \sqrt {group size} $$ , but negatively related to the rate of building. As for the delay of building, a non-monotone relation was found. The relation between number of hornets per group and the oviposition delay was found to be non-monotone; the number of hornets per group and their longevity were found to be inversely related. Discrepanices were recorded on the very small (1–2 individuals) or very large (100 individuals) hornet groups.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 97
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 527-537 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract A new method for reconstructing evolutionary relationship among bacteria by use of rRNA sequence data is proposed. The method is based on the concept of fuzzy classification of probabilitiesp(i), p(i/j) andp(i/j*) (i=A,G,C,U) of each sequence. The resulting partition tree shares common features of previous works but has some new peculiarities.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 98
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 619-630 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 99
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 631-650 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract We describe the behaviour of motile microorganisms (e.g. flagellates) attracted by “gyrotaxis” to a sinking, non-motile particle (e.g. an algal cell). The model is based on the application of Stokes' solution for the flow field around the settling cell. The volume within which the flagellate is attracted to the sinking particle is determined from the trajectories of the flagellate. The model of gyrotaxis has several applications; these include the colonization of sinking marine snow particles with motile microoganisms and suspension feeding by protozoa.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 100
    Digitale Medien
    Digitale Medien
    Springer
    Bulletin of mathematical biology 57 (1995), S. 507-526 
    ISSN: 1522-9602
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Mathematik
    Notizen: Abstract The effect of varying habitat dimensionality on the dynamics of a model predator-prey system is examined using an individual-based simulation. The general results are that in one dimension fluctuations in abundance of prey and predators occur over a large range of spatial scales (extinctions occur over many spatial scales). In two dimensions (and low mobilities of prey and predators) the dynamics become more predictably periodic at local scales and constant at larger scales due to statistical stabilization. In three dimensions, the model can become “phase-locked” with prey and predators displaying oscillations in abundance over large spatial scales.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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