Publication Date:
2011-01-05
Description:
Haskew-Layton et al. (1) reported that subtoxic doses of H2O2 fails to activate nuclear factor erythroid 2-related factor (Nrf2) in astrocytes and triggers Nrf2-independent responses that protect cocultured neurons. Contrary to this, we show that mild oxidative insults, including subtoxic H2O2, strongly activate astrocytic Nrf2/antioxidant response element (ARE)-dependent gene expression, which, moreover, contributes to neuroprotective ischemic preconditioning.In mixed neuron/astrocyte cultures (2, 3), treatment with physiologically relevant H2O2 doses (25–100 μM, similar/less than those recorded postischemia) (4) induced Nrf2-target genes sulfiredoxin (Srxn1) and heme-oxygenase 1 (Hmox1) in wild-type but not Nrf2−/− cultures (Fig. 1). Similarly, exposing cultures to oxygen–glucose deprivation (OGD;...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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