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  • Articles  (18)
  • NMR  (18)
  • Springer  (18)
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  • 1995-1999  (18)
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  • 1995  (18)
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  • Chemistry and Pharmacology  (18)
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  • Articles  (18)
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  • Springer  (18)
  • American Chemical Society
  • American Institute of Physics
  • American Meteorological Society
  • Elsevier
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  • 1995-1999  (18)
  • 1990-1994
  • 1965-1969
  • 1955-1959
  • 1950-1954
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  • 1
    Electronic Resource
    Electronic Resource
    Synthesis and characterization of alternating silane copolymers: (Me2Si−R2Si−Me2Si) n (1995)
    Springer
    Journal of inorganic and organometallic polymers and materials 5 (1995), S. 217-236 
    Details
    ISSN: 1572-8870
    Keywords: Polysilane ; NMR ; pyrolysis ; randomization
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Bimodal molecular weight distributions of alternating copolymers of the type (Me2Si−R2Si−SiMe2) n , where R=hexyl and butyl, were obtained by polymerization of BrSiMe2−R2Si−Me2SiBr, using the Wurtz coupling method. Analysis of the samples by pyrolysis GC MS and solution29Si NMR indicated that some randomization occurred, due to cleavage of the original Si−Si bonds in the monomer. The extent of randomization was significantly greater in the high molecular weight fractions. Based on the nature of the rings from the py MGC/MS traces and the number on nonads found in the29Si spectra, two types of randomization processes have been proposed, involving backbiting followed by (1) ring expulsion or (2) redistribution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01057894
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  • 2
    Electronic Resource
    Electronic Resource
    Direct hydrogen-1, carbon-13, and nitrogen-15 NMR study of magnesium(II)-isothiocyanate complexing (1995)
    Springer
    Journal of solution chemistry 24 (1995), S. 1249-1263 
    Details
    ISSN: 1572-8927
    Keywords: Hydrogen-1 ; carbon-13 ; nitrogen-15 ; NMR ; magnesiumisothiocyanate complexes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A hydrogen-1, carbon-13, and nitrogen-15 NMR study of magnesium(II)-isothiocyanate complexation in aqueous mixtures has been completed. At temperatures low enough to slow proton and ligand exchange, separate1H,13C, and15N NMR signals are observed for coordinated and bulk water molecules and anions. The1H NMR spectra reveal signals for the hexahydrate and the mono-through triisothiocyanato complexes, as well as two small signals attributed to [Mg(H2O)5(OH)]1+ and [Mg(H2O)4(OH)(NCS)]. Accurate hydration numbers were obtained from signal area integrations at each NCS− concentration. In the15N NMR spectra, signals also were observed for the mono-through triisothiocyanato complexes, and a small signal believed to be due to [Mg(H2O)4(OH)(NCS)]. Coordination number contributions for NCS− were measured from these spectra and when combined with the hydration numbers they totalled essentially six at each anion concentration. Signals for [Mg(H2O)5(NCS)]1+ through [Mg(H2O)3(NCS)3]1− also were observed in the13C NMR spectra and the area evaluations were comparable to the15N NMR results. An analysis of the magnitude and sign of the coordinated NCS− chemical shifts identified the nitrogen atom as the anion binding site. All spectra indicated [Mg(H2O)5(NCS)]1+ and [Mg(H2O)4(NCS)2] were the dominat isothiocyanato complexes over the entire range of anion concentrations. The inability to detect evidence for complexes higher than the triisothiocyanato reflects the competitive binding ability of water molecules and perhaps the decreased electrostatic interaction between NCS− and negatively charged higher complexes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00972831
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  • 3
    Electronic Resource
    Electronic Resource
    The steric structure of multiflorine methylation products (1995)
    Springer
    Monatshefte für Chemie 126 (1995), S. 233-239 
    Details
    ISSN: 1434-4475
    Keywords: Enaminoketones ; Lupin alkaloid ; Multiflorine ; NMR ; Nucleophilic methylation ; Stereospecificity
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung Multiflorin (1), ein Lupin-Nebenalkaloid, ergibt bei Umsetzung mit Methyllithium oder Methylmagnesiumiodid 4S-4-Hydroxy-4-methyl-2,3-didehydrospartein (2) und 2S-2-Methyl-4-oxospartein (3) als Hauptprodukte. Ihre NMR-spektroskopisch (1H und13C) aufgeklärte räumliche Struktur weist auf eine Stereoselektivität der erwähnten Reaktionen hin. Die beobachteten nucleophilen 1,2- und 1,4-Additionen zeigen, daß sich die Regiospezifität der Einwirkung von MeLi oder MeMgl auf Multiflorin von jener bis jetzt bekannter Alkylierungen von Enaminoketonen unterscheidet.
    Notes: Summary Multiflorine (1) — a minor lupine alkaloid — treated by methyl lithium or methyl magnesium iodide affords 4S-4-hydroxy-4-methyl-2,3-didehydrosparteine (2) and 2S-2-methyl-4-oxosparteine (3), respectively, as the dominating products. Their steric structure, determined by1H and13C NMR techniques, points to stereospecific preferences of these reactions. The observed nucleophilic 1,2- and 1,4-additions indicate that regiospecificity of the action of MeLi or MeMgI on multiflorine is different from that of the so far known similar alkylation of other enamino ketones.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00812252
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  • 4
    Electronic Resource
    Electronic Resource
    Synthesis and stereochemistry of 8-methyl-5-nitro-1-octalones (1995)
    Springer
    Monatshefte für Chemie 126 (1995), S. 1011-1019 
    Details
    ISSN: 1434-4475
    Keywords: Precursors of strigol analogues ; Michael reaction ; NMR ; Molecular modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Zusammenfassung BasenkatalysierteMichael-Addition von 5-Nitropentan-2-on-ethylenketal (1) und Cyclohex-2-enon (2), anschließende Entfernung der Schutzgruppe und darauffolgende Aldolkondensation liefert isomer 8-Methyl-5-nitro-1-octalone (5a,b). Struktur, relative Konfiguration und Konformation von5a und5b wurden mittels1H- und13C-NMR-Spektroskopie aufgeklärt.
    Notes: Summary Base catalyzedMichael addition of 5-nitropentan-2-one ethylene ketal (1) and cyclohex-2-enone (2), subsequent deprotection, and intramolecular aldol condensation yields the 8-methyl-5-nitro-1-octalone isomers (5a,b). The structure, relative configuration, and conformation of5a and5b were elucidated utilizing the results of1H and13C NMR investigations
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00811021
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  • 5
    Electronic Resource
    Electronic Resource
    Synthesis of aluminum rich MCM-41 (1995)
    Springer
    Catalysis letters 31 (1995), S. 267-272 
    Details
    ISSN: 1572-879X
    Keywords: MCM-41 synthesis ; NMR ; FTIR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The synthesis of MCM-41 mesoporous compounds with Si/Al ratios as low as 2 without observing the presence of octahedral Al in27AlMAS NMR is reported. FTIR spectra of chemisorbed pyridine indicated that MCM-41 materials in their protonated form exhibit both Brønsted and Lewis acid sites.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00808839
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  • 6
    Electronic Resource
    Electronic Resource
    MBOHO calculations of phosphorus-carbon nuclear spin-spin coupling constants (1995)
    Springer
    Theoretical chemistry accounts 92 (1995), S. 61-65 
    Details
    ISSN: 1432-2234
    Keywords: NMR ; Nuclear spin coupling constant ; Maximum bond order hybrid orbital ; Phosphorus-carbon coupling ; Net atomic charge
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary The novel generalized correlation of the nuclear spin-spin coupling constants with the atomic hybrids and net charges is employed to give a new relationship for calculating the directly bonded phosphorus-carbon coupling constants by use of the maximum bond order hybrid orbital procedure together with the extended Hückel molecular orbital calculation. The calculated coupling constants of phosphorus-carbon are all in good agreement with the experimental data, which shows that the new relationship obtained in the present paper is quite satisfactory for calculation of the phosphorus-carbon coupling constants.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01134204
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  • 7
    Electronic Resource
    Electronic Resource
    Determination of the structure of fusaproliferin by1H-NMR and distance geometry (1995)
    Springer
    Structural chemistry 6 (1995), S. 183-189 
    Details
    ISSN: 1572-9001
    Keywords: NMR ; distance geometry ; cluster analysis ; absolute configuration ; fusaproliferin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The absolute configuration of fusaproliferin, a toxic metabolite produced byFusarium proliferation, was determined by the combined use of1H NMR and distance geometry. The configuration of double bonds has been determined in agreement with NOESY buildup data. An R configuration for C10 was determined using Mosher's method. Processing the constraints obtained from NOESY experiments with a distance geometry program, a limited number (80) of possible structures was derived. An agglomerative nonhierarchical method of clustering was used in order to place these structures into classes suggested by the data, and not previously defined in any way. This statistical method showed that indeed the structures could be grouped in four classes. One of these classes is represented by a single structure, with the highest sum of violations and was discarded. All other structures have the same chirality; respectively S for C14 and R for C15. In solution the overall conformation is quite well defined in the region of the five-member ring and the planes of double bonds C2–C3 and C11–C12, while near to C8 and C9 internal flexibility appears evident.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02286446
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  • 8
    Electronic Resource
    Electronic Resource
    NMR study of the selective inhibition of water permeability of rat erythrocyte membrane (1995)
    Springer
    Bioscience reports 15 (1995), S. 55-63 
    Details
    ISSN: 1573-4935
    Keywords: water transport mechanisms ; NMR ; rat erythrocytes ; tritium effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract The inhibition of water diffusion across the rat erythrocyte membrane was studied by NMR using two basically different types of inhibitory agents: PCMB andin vivo irradiation. The contribution of lipid and protein to water permeability revealed the inhibitory effect of each pathway. Internal contamination with tritium (25–115 mGy) reduces water permeability due to protein modifications; for doses higher than 100 mGy the lipid mediated mechanism seems also to be impaired. The same procedure enables one to assess the extent to which the higher water permeability of rat, compared to human, erythrocyte is due to one of the two pathways.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01200215
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  • 9
    Electronic Resource
    Electronic Resource
    Chemical and rheological investigations of the sol-gel transition in organically-modified siloxanes (1995)
    Springer
    Journal of sol gel science and technology 4 (1995), S. 151-162 
    Details
    ISSN: 1573-4846
    Keywords: sol-gel transition ; rheology ; siloxane ; NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Ormosils are well-known organic-inorganic sol-gel derived materials also called heteropolysiloxanes. This paper presents two basic heteropolysiloxane structures where the organic part is either a short organic chain bridging two silicon atoms for the first material or an organic polymer backbone for the second. Their synthesis is detailed and a variety of experimental techniques (IR, 13C and 29Si NMR and CP-MAS NMR, GPC) have been employed to investigate the chemical structure of these new materials. Their mechanical properties, more precisely their viscoelastic behaviour, have been evaluated using dynamic rheological techniques. The storage and loss moduli have been followed during the sol-gel transition at fixed and variable oscillation frequencies. The results have been correlated to the 29Si CP-MAS NMR informations concerning the network polycondensation and compared to a pure inorganic sol-gel material prepared from tetraethoxysilane.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491681
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  • 10
    Electronic Resource
    Electronic Resource
    15N resonance assignments of oxidized and reducedChromatium vinosum high-potential iron protein (1995)
    Springer
    The protein journal 14 (1995), S. 115-126 
    Details
    ISSN: 1573-4943
    Keywords: NMR ; high-potential iron protein ; 15N assignment ; heteronuclear correlation ; paramagnetic
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The15N resonances in reduced and oxidizedChromatium vinosum high-potential iron protein have been assigned by use of1H-1H COSY spectra and1H-15N HMQC, HMQC-COSY, and HMQC-NOESY spectra. Unambiguous assignment of 70 of 85 backbone15N resonances in the reduced protein and 62 of 85 resonances in the oxidized protein are made, as are 12 of 21 side-chain15N resonances.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01980323
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  • 11
    Electronic Resource
    Electronic Resource
    Invertomers at nitrogen in aziridine carboxylates by mltltinuclear (1H,13C,17O, and15N) NMR study (1995)
    Springer
    Chemistry of heterocyclic compounds 31 (1995), S. 1071-1078 
    Details
    ISSN: 1573-8353
    Keywords: NMR ; 1H NMR ; 13C NMR ; 17O NMR ; 15N NMR ; aziridine-carboxylates ; configurational analysis ; conformational analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract A confrgurational and conformational study of NH, N-acetyl- and N-sulfonylaziridine carboxylates is performed by1H ,13C,17O, and15N NMR spectroscopy. The presence of acetyl and su fonyl groups on the ring nitrogen atom seems to reduce greatly the configurational stability at nitrogen.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01165053
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  • 12
    Electronic Resource
    Electronic Resource
    Hydrolysis of the Prodrug, 2′, 3′, 5′ -Triacetyl-6-azauridine (1995)
    Springer
    Pharmaceutical research 12 (1995), S. 1361-1370 
    Details
    ISSN: 1573-904X
    Keywords: 2′,3′,5′-triacetyl-6-azauridine ; prodrug ; hydrolysis ; pH-profile ; arrhenius plots ; CI-MS ; NMR ; liquid chromatography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Purpose. The purposes were to study the kinetics of hydrolysis of 2′,3′,5′-triacetyl-6-azauridine ( 1 ) in aqueous solution (µ = 0.5) and to identify the main intermediates and products of the reaction. Methods. A stability indicating isocratic LC assay was used to study the rate of degradation of 1 A gradient LC assay was used to study the time courses of the degradants. The products of hydrolysis were isolated by preparative liquid chromatography and identified by 1H-NMR and CI-MS. The pKa value was obtained by potentiometric titration. Results. At 36.8°C, the pH-rate profile of 1 in water was adequately described by a four-term rate equation. The intermediates were identified as the primary and secondary di-acetates, and the primary and secondary mono-acetates. The final product was 6-azauridine. Conclusions. A simplified kinetic scheme could be used to describe the concentration-time profiles of 1, the intermediates and the final product.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1016238110533
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  • 13
    Electronic Resource
    Electronic Resource
    Mammalian exocrine secretions: IX. Constituents of preorbital secretion of oribi,Ourebia, ourebi (1995)
    Springer
    Journal of chemical ecology 21 (1995), S. 1191-1215 
    Details
    ISSN: 1573-1561
    Keywords: Ourebia ourebi ; Bovidae ; mammalian semiochemicals ; mammalian pheromones ; exocrine secretion ; preorbital secretion ; dimethyl disulfide derivatization ; skipped dienes ; chemical-ionization mass spectrometry ; NMR
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Chemistry and Pharmacology
    Notes: Abstract Using gas chromatography-mass spectrometry in conjunction with ancillary techniques such as chemical ionization with different reactant gases, determination of the position of double bonds by means of dimethyl disulfide derivatization, and finally gas chromatographic and mass spectrometric comparison with authentic synthetic material, 75 constituents were identified in the preorbital secretion of the male oribi,Ourebia ourebi. The secretion contains compounds with long-chain, unbranched structures similar to those found in many other preorbital secretions but with a finite volatility range, in contrast to the seemingly endlessly increasing chain lengths typical of other preorbital secretions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02228320
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  • 14
    Electronic Resource
    Electronic Resource
    New backbone cyclic substance P analogs (1995)
    Springer
    International journal of peptide research and therapeutics 2 (1995), S. 121-124 
    Details
    ISSN: 1573-3904
    Keywords: Backbone cyclization ; Substance P ; NMR ; Molecular dynamics ; Conformational analysis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Structure-activity relationships of cyclic substance P (SP) analogs were extensively studied in our laboratories utilizing the new concept of backbone cyclization. Employing the C-terminal hexapeptide SP6–11, we examined the influence of chemical changes in peptides containing backbone-to-amino-end cyclization. These changes in the ring have significant influence on activity, and should be carefully designed in order to optimize pharmacological feature.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00119137
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  • 15
    Electronic Resource
    Electronic Resource
    Production, isolation and characterization of [Leu4]- and [Ile4]surfactins from Bacillus subtilis (1995)
    Springer
    International journal of peptide research and therapeutics 2 (1995), S. 41-47 
    Details
    ISSN: 1573-3904
    Keywords: Biosurfactant ; Lipopeptide ; NMR ; Hydrophobic substitution
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Bacillus subtilis coproduces several surfactin variants that are powerful biosurfactants and have potential applications in biology and industry. A single amino acid substitution in the heptapeptide moiety of surfactins strongly modifies their properties. To better establish structure-activity relationships and to search new variants with enhanced properties, Bacillus subtilis was grown into two modified culture media. Two new variants were isolated by chromatographic methods and studied by NMR spectroscopy. As planned, modifications consisted in the substitution of the l-valine residue at the fourth position by a more hydrophobic residue, i.e., leucine or isoleucine. These [Leu4]- and [Ile4]surfactins have a higher affinity for hydrophobic solvents and a twice improved surfactant power. Structure-property correlations were confirmed by analysis of the hydrophobic residue distribution in the three-dimensional model of the structure of surfactin in solution.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00122922
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  • 16
    Electronic Resource
    Electronic Resource
    Structure of Leu5-enkephalin bound to a model membrane as determined by high-resolution NMR (1995)
    Springer
    International journal of peptide research and therapeutics 2 (1995), S. 59-70 
    Details
    ISSN: 1573-3904
    Keywords: Opioid peptide ; NMR ; Enkephalins ; Micelles ; Dodecylphosphocholine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Opioid peptides are thought to interact with the cell membrane in their biological journey to the membrane-bound receptor. Both organic solvents and model membranes have been used previously to determine the stable solution conformations of peptide hormones. Leucine enkephalin has been studied in a number of different environments, but with limited resolution. Here it is shown that leucine enkephalin forms a stable type IV β-turn structure in dodecylphosphocholine micelles. We have observed a highly solvent-shielded amide proton with no evidence for a complementary hydrogen bond acceptor. The structural details of the peptide as determined by NMR spectroscopy in solution are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00128499
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  • 17
    Electronic Resource
    Electronic Resource
    New conformationally constrained Xxx-Pro bicyclic mimetics (1995)
    Springer
    International journal of peptide research and therapeutics 2 (1995), S. 161-164 
    Details
    ISSN: 1573-3904
    Keywords: Cyclised peptide ; Dioxopiperazine ; Thiazolidine ; NMR ; Computer modelling
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary Conformationally constrained peptidomimetics of the Lys-Pro sequence have been obtained using a new polycyclic structure. Bicyclic compounds containing a dioxopiperazine-thiazolidine fused ring have been synthesised starting from N-lysyl-4-ethoxycarbonylthiazolidine-2-carboxylic acid. The carboxyl group in either position 2 or 4 of the thiazolidine ring was reacted with the N-terminal amino group, giving different regioisomers. NMR and computer modelling were used to study the configuration of isomers and the lysine side-chain orientation with respect to the pseudoproline ring.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00119143
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  • 18
    Electronic Resource
    Electronic Resource
    Synthesis and conformational analysis of AzAsx-containing oligopeptides (1995)
    Springer
    International journal of peptide research and therapeutics 2 (1995), S. 239-242 
    Details
    ISSN: 1573-3904
    Keywords: Pseudopeptide ; Triphosgene ; Beta-turn ; NMR ; FT-IR ; X-ray diffraction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Summary For the sake of improving synthetic methods and evaluating the conformational perturbation induced by the substitution of AzAsx for the Asx residue in the cognate dipeptide R-CO-Asx-Pro-NHR′, we prepared the AzAsx-dipeptide sequence by making use of the crystalline triphosgene. This reagent allows, in situ and under very mild experimental conditions, both the carbonylation and the activation of the properly substituted and N-protected hydrazine before coupling with the proline partner. With regard to conformational behaviour, the azadipeptide sequence displays a β-fold, unlike the cognate dipeptide which adopts an Asx-turn.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00119162
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