ISSN:
1573-8221
Schlagwort(e):
glucocorticoids
;
α-fetoprotein
;
liver
;
carbon tetrachloride
Quelle:
Springer Online Journal Archives 1860-2000
Thema:
Biologie
,
Medizin
Notizen:
Abstract Experiments on male C57BL mice showed that inhalation of CCl4 for 15 min in a concentration of 0.05 ml/4 liters air causes severe degenerative changes in the liver with features of necrobiosis. However, phenomena of regeneration and cell infiltration arise as early as after 24 h and are accompanied by the secretion of α-fetoprotein into the blood stream. After 4 days the foci of necrobiosis disappear and are totally replaced by lymphocytes with large hepatocytes at the periphery. Processes of regeneration in animals receiving hydrocortisone (20 mg/kg) or dexamethasone (2 mg/kg) therapeutically or prophylactically were less marked and the number of animals producing α-fetoprotein was reduced from 92 to 60–65%.
Materialart:
Digitale Medien
URL:
http://dx.doi.org/10.1007/BF00799405
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