Publication Date:
1982-11-12
Description:
The contractile response of the guinea pig vas deferens to motor nerve stimulation is biphasic. The first phase is antagonized by the specific adenosine triphosphate-receptor antagonist arylazido aminoproprionyl adenosine triphosphate (ANAPP3), and the second by the alpha-receptor antagonist prazosin. The underlying electrical event, the excitatory junction potential, is also blocked by ANAPP3, but not by prazosin.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Sneddon, P -- Westfall, D P -- Fedan, J S -- New York, N.Y. -- Science. 1982 Nov 12;218(4573):693-5.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/6291151" target="_blank"〉PubMed〈/a〉
Keywords:
Adenosine Triphosphate/analogs & derivatives/pharmacology/*physiology
;
Animals
;
*Azides
;
Guinea Pigs
;
Male
;
Motor Neurons/*physiology
;
Muscle Contraction/drug effects
;
Muscle, Smooth/physiology
;
Norepinephrine/*physiology
;
Prazosin/pharmacology
;
Receptors, Adrenergic, alpha/physiology
;
Receptors, Cell Surface/physiology
;
Vas Deferens/*innervation
Print ISSN:
0036-8075
Electronic ISSN:
1095-9203
Topics:
Biology
,
Chemistry and Pharmacology
,
Computer Science
,
Medicine
,
Natural Sciences in General
,
Physics
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