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  • Artikel  (16)
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  • 1
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 36 (1984), S. S129 
    ISSN: 1432-0827
    Schlagwort(e): Bone mass ; Exercise ; Aging women ; Osteoporosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Physical activity is an important stimulus in the prevention of bone involution. Bilateral bone mineral mass and width of the radius, ulna, and humerus were measured by single photon absorptiometry on 200 women between the ages of 35 and 65 over a 3–4 year period. Two groups were formed: 80 in a control group and 120 in a physical activity group exercising 45 min/day, 3 days/week. The control and physical activity groups were similar in age, height, weight, and level of physical fitness at the beginning of the study. The control group lost bone mineral mass at a rate similar to that of the general population. The left radius bone mineral declined 2.44% per year. Similar rates of decline were observed in the other bones measured. The physical activity group increased in fitness by 13% in the first year of the study. The bone mineral mass of the exercise group declined the first year and then increased; thereby the bone mineral data for the exercise group was analyzed in two sets. During the first year of the program, a decline of 3.77% in bone mineral mass of the left radius, a significantly greater loss than that of the control group, was observed. Decline rates were similar in the other bones measured. In the second and third years, bone mineral mass of the left radius increased by 1.39% per year, and the rate of change was significantly different from that of the control group. There were similar increases in the other bones measured. The data from this study support the importance of physical activity in the prevention of bone mineral loss in the aging female.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    ISSN: 1432-0827
    Schlagwort(e): 99mTc-pyrophosphate ; Bone metabolism ; Osteoporosis ; Osteomalacia ; Hyperparathyroidism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The retention of99mTc-labeled pyrophosphate (PPi) at 24 h was measured in 235 patients, 119 of whom had a normal bone metabolism. The mean retention in the group of normal subjects is 52% of the injected dose. Reproducibility of the measurement in a given person is 5.5% coefficient of variation (CV). The value depends strongly on sex (higher in males) and age (higher with increasing age, especially in cortical bone). Retention increases slowly with the decrease in glomerular filtration rate (GFR) between 50 and 120 ml/min; it rises very rapidly with values below 50 ml/min. The slowing down of the GFR with age does not account for the increase in PPi retention with age. When expressed as a percentage of the expected value for sex and age, retention is frequently low in osteoporosis (P〈.001), more so when urinary hydroxyproline is low; it is normal or high in osteomalacia, and in some cases rises after vitamin D treatment is started; it is high in hyperparathyroidism (P〈.01). The PPi retention is correlated with bone calcium accretion rate, alkaline phosphatase level, and above all, the urinary hydroxyproline level. The lower the bone mineralization (Ca/hydroxyproline ratio in biopsy), the higher the retention value. We conclude that the PPi retention is an index of bone metabolism when GFR is higher than 50 ml/min. It allows for classification of metabolic bone diseases according to the bone turnover rate. It has the advantage over the usual biologic examinations in that it affords better observation of highly localized bone disorders and can be used in combination with a morphologic record, the bone scintigraphy.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 35 (1983), S. 148-152 
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Computed tomography ; Densitometry ; Osteoporosis ; Osteomalacia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The linear attenuation coefficient (μ in cm1) of trabecular bone was modeled for different conditions of bone and marrow composition in order to assess their influence on computed tomography (CT) quantitation. A large relative change (10% of TBV at 15% TBV) of bone concentration resulted in small changes of μ: 2.3% at 60 keV, 3.4% at 44 keV, 5.2% at 29 keV. Relative changes of trabecular bone volume (TBV) on the order of 3% could be detectedin vivo by CT were it not for errors of relocation and for compositional influences on accuracy. The μ (and density) depended critically not only on amounts of bone substance and marrow but on their compositions. Normal variation in the composition of bone substance produced an uncertainty in μ equivalent to 0.5 to 1% TBV. Increases of yellow marrow produced a decrease of μ which could be mistaken for a decrease of bone concentration. The biological variation (90% confidence limit) of marrow composition gives an uncertainty at 15% TBV of about 2.4% TBV at 60 keV, 1.7% at 44 keV, and 1.3% at 29 keV. These correspond to relative uncertainities of 16, 11, and 9% respectively. These factors help explain the large accuracy errors (30%) observed in all studies of trabecular bone where single-energy CT was used. Marrow composition also can affect precision of bone measurement. Systematic shifts of red and yellow marrow could mask biological changes such as those occurring with aging or treatment.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 35 (1983), S. 410-417 
    ISSN: 1432-0827
    Schlagwort(e): Bone remodeling ; Histomorphometry ; Corticosteroid therapy ; Osteoporosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary We have compared the mean wall thickness (MWT) and active formation periods (sigmaf(A)) of trabecular bone packets in iliac crest biopsies from 20 patients (7 male, 13 female) with corticosteroid-induced osteoporosis (CS-OP) and 20 age- and sex-matched controls. The trabecular bone volume (TBV) of the CS-OP patients (9.6%±2.2% [SD]) was significantly reduced compared to controls (19.3%±5.1%). The MWT of CS-OP patients (32.7±4.3 µm) was also significantly lower than the control value (48.0±6.2 µm). There was a positive correlation between MWT and TBV in both groups. The mineralization rate (M) of the CS-OP patients (0.54±0.25 µm/day) was within the normal range, and since there was no increase in osteoid seam thickness, so therefore was the osteoblastic appositional rate (OAR). The active formation period of trabecular bone packets (sigmaf(A)=MWT/M) was significantly lower in the CS-OP patients (55.9 ± 14.4 days) than in the control group (68.1 ± 9.4 days). MWT and sigmaf(A) both decreased with age in the control group, whereas in the CS-OP group they were independent of age. We conclude that corticosteroid therapy results in a reduction of the MWT of trabecular bone packets and, consequently, of TBV. In these patients, where the OAR was normal, the reduction in MWT was apparently caused by a shortening of the lifespan of the active osteoblastic population at the basic multicellular unit (BMU) level.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 35 (1983), S. 5-8 
    ISSN: 1432-0827
    Schlagwort(e): Osteoporosis ; Quantitative bone histology ; Bone metabolism ; Developmental bone disease ; Growth disorder
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary A previously healthy 12-year-old boy developed pain on walking and x-rays showed osteoporosis. Over the next 2 years deterioration occurred, the condition became extremely severe, and he was confined to a wheelchair. After 5 years, marked kyphoscoliosis and pigeon chest deformity were present and little increase in height occurred. A wheelchair accident at the age of 17 resulted in several major long bone fractures. Iliac crest biopsies were taken at ages 15 and 17, and subjected to quantitative histology. A histochemical technique for osteoclast recognition by acid phosphatase activity showed resorption parameters to be normal. Double tetracycline labeling and histochemical identification of osteoblasts showed no abnormality of endosteal bone formation. Because of “coupling” of endosteal formation and resorption, these measurements might primarily reflect bone turnover. Failure of periosteal bone formation as shown by failure of radial growth of long bones and of epiphyseal growth was clearly evident. It is likely that osteoporosis developed in this patient due to a reduction in bone formation of unknown etiology rather than by increased bone resorption.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 36 (1984), S. 302-307 
    ISSN: 1432-0827
    Schlagwort(e): Metabolism ; pH ; Fluorosis ; Osteoporosis ; Toxicity
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary The influence of gastric acidity on the absorption of intragastrically administered fluoride was investigated in rats. Intact animals were pretreated with atropine or cimetidine to reduce gastric acid secretion or were given fluoride in NaHCO3 to reduce the acidity of the gastric contents. Compared with pentagastrin-treated animals or animals that received fluoride in 0.1 N HCl, their rate of fluoride absorption was markedly reduced as judged by lower plasma fluoride concentrations and areas under the time-plasma concentration curves, especially during the first hour after dosing. In crossover studies with the stomachs isolatedin situ, fluoride absorption was at least 50% faster from a pH 2.1 buffer compared with its absorption from a pH 7.1 buffer. The findings are consistent with the hypothesis that fluoride is absorbed from the gastric lumen principally as the undissociated molecule, HF. The results may contribute to a more complete understanding of acute fluoride toxicity, the development of dental fluorosis and, perhaps, the use of fluoride in the treatment of osteoporosis.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 36 (1984), S. 431-434 
    ISSN: 1432-0827
    Schlagwort(e): Bendroflumethiazide ; Hydrochlorothiazide ; Calcium hydroxyapatite ; Hydrolysis ; Osteoporosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Inhibition of dissolution of calcium hydroxyapatite in the presence of bendroflumethiazide, Centyl®, and of hydrochlorothiazide has been investigated. The former compound has a pronounced larger inhibitory effect than the latter. The trifluormethyl group in bendroflumethiazide has been shown to hydrolyze, with the release of fluoride and hydrogen ions, presumably forming a carboxylic acid. The inhibitory effect of hydrolyzed bendroflumethiazide is found to be similar to the effect of a potassium fluoride solution with the same fluoride ion concentration, as measured by a fluoride selective ion electrode.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    ISSN: 1432-0827
    Schlagwort(e): Osteoporosis ; Renal osteodystrophy ; Fractures ; Bones and bone disease ; Absorptiometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Dual-photon absorptiometry (153Gd) was used to measure bone mineral of the total body and major anatomical areas. Patients with osteoporosis (♂=11, ♀=18) and with renal osteodystrophy (n=17) were significantly below (20%) normal females (n=72) and males (n=13) at most sites. In the osteoporotic patients, but not the renal patients, there was preferential osteopenia of the spine. Bone loss in all anatomical areas became evident after the menopause with an annual loss rate of about 0.7%.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 35 (1983), S. 392-393 
    ISSN: 1432-0827
    Schlagwort(e): Osteoporosis ; Infrared ; Bone mineral ; Bone resorption
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary An infrared and x-ray diffraction study of osteoporotic and normal, archaeological Eskimo bones. Osteoporotic bone apatite is greater in crystal size and/or perfection and lower in CO3 than normal bone apatite.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 36 (1984), S. S56 
    ISSN: 1432-0827
    Schlagwort(e): Mechanical strain ; Bone remodeling ; Osteoporosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Mechanical function has always been acknowledged to have a significant, continuing but hitherto unquantified influence on bone remodeling. The structural objective of this relationship is presumably to ensure that, at each location throughout the skeleton, there is sufficient bone tissue, appropriately placed, to withstand functional load-bearing without damage. The architectural modifications necessary to achieve and maintain this structural competence are made by the coordinated remodeling activity of populations of osteoblasts and osteoclasts. The specific structure-function objectives at each location remain undefined, as are the mechanisms by which tissue loading is transduced into cellular control. The remodeling responses following a variety of experimental alterations in bones' strain environment are presented. Their significance to the process of remodeling control is discussed, and a scheme for the interaction of mechanical and hormonal influences proposed.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 35 (1983), S. 29-31 
    ISSN: 1432-0827
    Schlagwort(e): Mast cells ; Osteoporosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Because mast cell proliferation has been reported in disorders of abnormal bone remodeling, we quantitated the number of mast cells in undecalcified section of iliac crest bone from 16 untreated women with postmenopausal osteoporosis and contrasted the findings to values from 10 normal women and 12 normal men. The mean number of marrow mast cells was greater in normal women than men (1.17 vs 0.40 cells per mm2,P〈0.05). Compared to the normal women, osteoporotic women had a greater number of mast cells in the marrow (3.38 vs 1.17 cells per mm2,P〈0.01). However, there was no statistically significant correlation between the number of marrow mast cells and either the patient's age or the severity of the bone lesions, as assessed by histomorphometry. Our findings confirm the association between increased numbers of mast cells and postmenopausal osteoporosis.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 36 (1984), S. 341-343 
    ISSN: 1432-0827
    Schlagwort(e): Osteoporosis ; Coherence Therapy ; Histomorphometry
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Five patients suffering from osteoporosis were subjected to from three to eight cycles of a form of Coherence Therapy for Osteoporosis (1) used at this center. Assessment of the patients' trabecular bone remodeling activity as measured by histomorphometric analyses of trans-iliac crest bone biopsies showed a marked improvement.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 13
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 36 (1984), S. 725-728 
    ISSN: 1432-0827
    Schlagwort(e): Race ; Osteoporosis ; Calcitonin ; Katacalcin
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Profound racial differences exist in the incidence of osteoporosis, particularly in women. To investigate possible underlying reasons for this, we have measured the circulating levels of calcitonin (iCT), a bone-protecting hormone, and its flanking peptide, katacalcin (iKC), in black Gambian and white British populations. Whilst sex differences in both peptides were observed, with males having higher levels than females, the most striking finding was that white women have the lowest iCT levels. This important observation may explain, at least in part, why osteoporosis is particularly a disease of white, postmenopausal women.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 14
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 36 (1984), S. 591-595 
    ISSN: 1432-0827
    Schlagwort(e): Fracture ; (Glucocorticoid ; 1,25(OH)2D3 ; Osteoporosis ; Rabbit
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary A closed tibial fracture, which was controlled by an intramedullary stainless steel pin, was created in 16 rabbits. Eight rabbits were treated with 75 ng of 1,25(OH)2D3 daily as subcutaneous (s.c.) injections. After three weeks, the fractured tibia resisted a force of 101,7±21.0 Newtons in the control group and 57.3±8.0 Newtons in animals given 1,25(OH)2D3 (m±SE,P〈0.05). In another group of eight rabbits, the left hindleg was immobilized in a plastic splint. Four rabbits were given 75 ng of 1,25(OH)2D3/day s.c. and the effect of immobilization was studied on the calcaneus. Bone ash/cm3 of the calcaneus on the immobilized side was decreased by 11±2% in control rabbits and by 20±2% in the group treated with 1,25(OH)2D3 indicating a more advanced immobilization osteoporosis (m±SE,P〈0.05), which was also demonstrated by studies of bone density. Eighteen rabbits were used in a study of the effects of 1,25(OH)2D3 on the development of prednisolone osteoporosis. The dose of prednisolone was 2.5 mg per day, given by the oral route. After four months, the density of the femur was 1.53±0.02 g/cm2 in control rabbits and 1.42±0.01 in prednisolonetreated animals (P〈0.01). In rabbits additionally given 1,25(OH)2D3, the mean value for bone density was further lowered (n.s.). It appears that 1,25(OH)2D3 exaggerates disuse osteoporosis and prednisolone osteoporosis and impairs fracture healing in rabbits. These results differ from what has been shown earlier with 1,25(OH)2D3 treatment in the rat.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
    Digitale Medien
    Digitale Medien
    Springer
    Calcified tissue international 35 (1983), S. 107-110 
    ISSN: 1432-0827
    Schlagwort(e): Calcium ; Glucocorticoid ; Vitamin D ; Osteoporosis ; Rat
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Eighty-eight adult male Sprague-Dawley rats were given a diet with either (a) 0.5% Ca and 0.6% P or (b) 0.01% Ca and 0.6% P. Osteopenia was created by adding prednisolone to the diet. The prophylactic effect of oral 1,25(OH)2D3 on the osteopenia was studied. It was found that prednisolone osteopenia in the rat was associated with defective Ca absorption. By giving an oral dose of 1,25(OH)2D3, it was possible to maintain normal Ca absorption during prednisolone treatment and to prevent the bone loss. No significant hypercalcemia or any kidney calcifications were seen. These results are in contrast to earlier findings, in which subcutaneous administration of 1,25(OH)2D3 failed to prevent prednisolone osteopenia because of its tendency to increase bone resorption.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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  • 16
    ISSN: 1432-0827
    Schlagwort(e): Bone resonant frequency ; Osteoporosis ; Osteomalacia
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary A new computerized apparatus was constructed to measure the resonant frequency of human ulnain vivo with high sensitivity and reproducibility. Experimental studies using aluminum bar and dried human bone revealed the importance of the ulna being positioned parallel to the radius, approximately 90 degree flexion of the elbow joint, and minimal muscle activity in order to demonstrate maximum resonant frequency of ulna. Measurement of bone resonance in monkeysin vivo and after removal of the bonein vitro showed good agreement. Product of F (maximum resonant frequency in Hz) and L (ulnar length in cm), FL, indicating the speed of propagation of sound wave through the ulna, showed a significant positive correlation with bone mineral content/bone width (BM/BW) measured by Norland-Cameron apparatus and age-bound decline in both sexes. Patients with osteomalacia and primary hyperparathyroid bone disease tended to have higher FL values than expected from BM/BW. Two-dimensional display of FL and BM/BW thus appears to be useful in distinguishing osteoporosis from osteomalacia better than the use of BM/BW alone.
    Materialart: Digitale Medien
    Standort Signatur Erwartet Verfügbarkeit
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