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  • Springer  (75,874)
  • 1990-1994
  • 1980-1984
  • 1970-1974  (69,918)
  • 1930-1934  (5,956)
  • 1972  (36,116)
  • 1971  (33,802)
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  • 1990-1994
  • 1980-1984
  • 1970-1974  (69,918)
  • 1930-1934  (5,956)
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  • 1
    Electronic Resource
    Electronic Resource
    Contributions to the theory of organismic sets, II: Aggressiveness and submissiveness (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 49-54 
    Details
    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract In the theory of organismic sets (Bull. Math. Biophysics,31, 159–198, 1969) we considered organisms as sets endowed with certain “activities,” the latter’s resulting in a set of “products.” Those products may be of a material nature, like a hormone secreted by a cell, or of a non-material nature, like a feeling or an attitude. In the present paper aggressiveness and submissiveness are considered as such non-material products of the activities of the brain cells. A general description of aggressiveness and submissiveness is given in terms of organismic sets. Cycles in “peck order” are thus naturally explained.
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    URL: http://dx.doi.org/10.1007/BF02476664
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  • 2
    Electronic Resource
    Electronic Resource
    Contribution to the theory of organismic sets, III (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 55-66 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract In line with previous studies on organismic sets, the division of all organismic sets intogeneral autotrophic and heterotrophic is introduced. The first produce their food themselves from some external source of energy, which in general may be an energy of any kind. The others use other organismic sets as the source of their food and energy. On earth we know only one kind of generalgeneral autotrophic organismic sets, namely, the autotrophic plants which use solar radiation as their source of energy and for production of their own food. It is shown why autotrophic animals do not exist on earth except as microorganisms like, e.g.,Euglena. A rigorous proof of the previously derived theorem that in an organismic set of ordern〉1 no element can be completely specialized is given. It requires the introduction of new postulates. Finally, in considering the organic world as a whole, the notion of organismic sets ofmixed order is introduced.
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    URL: http://dx.doi.org/10.1007/BF02476665
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  • 3
    Electronic Resource
    Electronic Resource
    “A stochastic solution of the 3-body problem in chemical kinetics. The termolecular stochastic process I” (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 67-81 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract It appears to be axiomatic that termolecular and higher order reactions occur relatively rarely. The basis for this judgment seems to lie in the supposition that successful 3-Body collisions of 3 interactive species of molecules cannot occur frequently enought to account for chemical or biochemical transformation. In order to provide a more complete mathematical framework than now exists for examining this hypothesis the probability of effective termolecular “δ-collisions” as a function of time is derived. This amounts to adding to the class of reactions for which stochastic models are now available the termolecular reaction. In common with the unimolecular and bimolecular cases this process is seen to satisfy the criterion of consistency-in-the-mean with respect to deterministic formulations. It is planned next to use the termolecular process and the lower order processes in computer-assistedin numero experimental studies aimed at comparing alternative mechanisms of reaction.
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    URL: http://dx.doi.org/10.1007/BF02476666
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  • 4
    Electronic Resource
    Electronic Resource
    Maximum likelihood estimation for stochastic first order reactions (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 83-96 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Small sample properties of the maximum likelihood estimator for the rate constant of a stochastic first order reaction are investigated. The approximate bias and variance of the maximum likelihood estimator are derived and tabulated. If observations of the system are made at timesiτ,i=1, 2, ...,N; τ〉0, the observational spacing τ which minimizes the approximate variance of the maximum likelihood estimator is found. The non-applicability of large sample theory to confidence interval derivation is demonstrated by examination of the relative likelihood. Bartlett’s method is employed to derive approximate confidence limits, and is illustrated by using simulated kinetic runs.
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    URL: http://dx.doi.org/10.1007/BF02476667
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  • 5
    Electronic Resource
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    Organismic supercategories and qualitative dynamics of systems (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 339-354 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The representation of biological systems by means of organismic supercategories, developed in previous papers (Bull. Math. Biophysics,30, 625–636;31, 59–71;32, 539–561), is further discussed. The different approaches to relational biology, developed by Rashevsky, Rosen and by Băianu and Marinescu, are compared with Qualitative Dynamics of Systems which was initiated by Henri Poincaré (1881). On the basis of this comparison some concrete result concerning dynamics of genetic system, development, fertilization, regeneration, analogies, and oncogenesis are derived.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02476778
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  • 6
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    Some realizations of (M, R)-systems and their interpretation (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 303-319 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Some years ago (Rosen 1958a, b; 1959) we described a class of metaphorical, relational paradigms for cellular activity which we termed (M, R)-systems. A sizable amount of subsequent work, to be itemized below, has been devoted to an exploration of some of the properties of these systems. The main purpose of the present paper is to put this class of paradigms into a general system-theoretic perspective, with a particular view to appraising the relation between the type of system description embodied in the (M, R)-system and other kinds of physical and mathematical descriptions of cellular systems. Thus, the principal aim is to establish the relationships and connections between the global relational formalism embodied in the (M, R)-systems and the empirical descriptions which still represent the bulk of our biological knowledge.
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    URL: http://dx.doi.org/10.1007/BF02476776
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  • 7
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    Relational forces and structures produced by them (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 321-338 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract After giving a brief review of the theory of organismic sets (Bull. Math. Biophysics,29, 139–152, 1967;31, 159–198, 1969), in which the concept of relational forces, introduced earlier (Bull. Math. Biophysics,28, 283–308, 1966a) plays a fundamental role, the author discusses examples of possible different structures produced by relational forces. For biological organisms the different structures found theoretically are in general agreement with observation. For societies, which are also organismic sets as discussed in the above references, the structures can be described only in an abstract space, the nature of which is discussed. Different isomorphisms between anatomical structures, as described in ordinary Euclidean space, and the sociological structures described in an abstract space are noted, as should be expected from the theory of organismic sets.
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    URL: http://dx.doi.org/10.1007/BF02476777
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  • 8
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    Probabilistic and multiple regression modeling of the biologist’s decision processes and its implications for medical diagnosis (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 439-449 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Current psychological research into the inference (diagnostic) process is briefly reviewed, using as a vehicle an investigation of the prediction of the probability of success of hypothetical applicants to a graduate program in biology. Brunswik’s lens model and multiple regression analysis are used, as is a Bayesian approach. Four judges’ (biologists’) predictions are analyzed. Some general conclusions about inference, drawn from the current data in psychology, are presented.
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    URL: http://dx.doi.org/10.1007/BF02476785
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  • 9
    Electronic Resource
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    Anin numero study of glucose-insulin interaction (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 451-462 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A mathematical model has been developed to simulate the glucose-insulin interaction following a glucose load such as occurs in an IVGTT. This model differs from earlier models in that the insulin response to glucose loading is a recurring all or none threshold response. The model has been simulated on a digital computer using the digital analog simulation language CSMP.
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    URL: http://dx.doi.org/10.1007/BF02476786
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  • 10
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    Wave propagation in bone media (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 463-479 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The composite nature of bone dictates the use of a model for bone which is transversely isotropic. We solve the associated sets of partial differential equations governing the dynamic elastic behavoor of a two-layered cylindrical-shaped bone. The solution is analyzed for long, short, and intermediate length waves. The special case of compact bone is treated for long and short wave lengths and a numerical example is worked out to determine the wave speeds (for short wave lengths) given a set of elastic constants, determined by ultrasonic methods, and the bone density, wave frequency, and radius.
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    URL: http://dx.doi.org/10.1007/BF02476787
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  • 11
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    Fourth International Biophysics Congress (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 481-481 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
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    URL: http://dx.doi.org/10.1007/BF02476788
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  • 12
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    Obituary of Nicolas Rashevsky (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. i 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
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    URL: http://dx.doi.org/10.1007/BF02477019
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  • 13
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    On the stochastic theory of compartments: I. A single-compartment system (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 53-63 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A stochastic model is developed for a compartment with a single time-dependent input, and generalized to include inputs from several sources. With the number of particles of a given molecular species in the compartment as the random variable, the mean, variance and third central moment of this variable are calculated from its generating function, and compared with previous results. The behavior of the calculated moments is discussed, and the possibility of applying the model to chemical and biological systems is considered.
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    URL: http://dx.doi.org/10.1007/BF02477024
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  • 14
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    A remark on sensory deprivation from the point of view of organismic sets (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 439-441 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract It is shown that from the definition of organismic sets (Rashevsky,Organismic Sets. Some Reflections on the Nature of Life and Society, Holland, Michigan, Mathematical Biology, Inc. and Grosse Pointe, Michigan, J. M. Richards Laboratory) a complete sensory deprivation of an organismic set of ordern=2 should result in malfunctioning of the set. A generalization to higher order sets is suggested.
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    URL: http://dx.doi.org/10.1007/BF02476706
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  • 15
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    Optimal branching structure of the vascular tree (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 431-438 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Optimality in branching structure of the vascular tree was studied. Analysis on its physiological roles as the duct system for blood supply to the capillaries predicted that the vascular tree should be constructed with minimum volume under restriction of determinant pressure, flow and location at the origin and the terminals. Mathematical derivations of this conditional extremum problem yielded some equations expressing the relations between the radii of the branches and their branching angles, which provided numerical solutions for branching points of bi- and poli-terminal minimum volume trees. Comparison of the peritoneal vascular tree in a dog with the minimum volume one computed under the same restrictive conditions showed good agreement in their branching structure.
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    URL: http://dx.doi.org/10.1007/BF02476705
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  • 16
    Electronic Resource
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    First order kinetics in a distributed model (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 443-456 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract In order to determine the kinetics of passage of a substance through an organ containing a tangle of vessels, we study the response of a tube to various inflows (perfusion, brief injection, ...). The introduction of the catabolic terms and of the spatial dependence between bulk concentration and surface concentration allows one to account for the difference of arteriovenous concentrations observed experimentally for many metabolites. The relationships between the physico-chemical parameters of the organ and the operational parameters of the model demonstrate the importance of the transit time through the considered vessels. If one considers the different pathways as independent, the introduction of the transit time distribution for an inert substance enables one to compute the response of the organ analytically or by recurrence, using convolution. The parameters of the model can be obtained by the moments method.
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    URL: http://dx.doi.org/10.1007/BF02476707
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  • 17
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    Stochastic simulation of the gas diffusion in the air phase of the human lung (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 457-466 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The solution of the diffusion equation in the gas phase of the human lung is very difficult because of the structure of the bronchial tree. It is shown by means of physical arguments, how one can reduce the diffusion equation to a simple one-dimensional form. The solution is then obtained by a stochastic simulation, which is easily realized on a digital computer.
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    URL: http://dx.doi.org/10.1007/BF02476708
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  • 18
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    A new mathematical model of the respiratory center (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 467-481 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A new mathematical model of the oscillatory behavior of the respiratory center has been developed based upon published records of neuronal activity during respiration in the pons and medulla. In contrast with a previous model, four, rather than two, networks are assumed to interact in the respiratory center so as to produce the respiratory oscillation. A mathematical description of this interaction, in the form of a set of four first-order, nonlinear, coupled differential equations, is derived; the behavior of the solutions of this system is studied qualitatively, and expressions for the durations of the inspiratory and expiratory phases are obtained in terms of some parameters. It is found that central and chemical influences drive the medullar neurons to a position somewhere between saturation and full cutoff, and the pontine neurons deeply into cutoff. The control of the duration of the different phases by these chemical and central means is discussed. In order to effect a decrease in the magnitude of the various times, the neurons have to be driven towards operating points of higher central facilitation.
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    URL: http://dx.doi.org/10.1007/BF02476709
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  • 19
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    A mathematical model for calcium homeostasis (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 483-502 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract In vivo control of calcium is analysed under the assumption that hormonal influences via plasma levels of parathormone and calcitonin are of prime (but not absolutely dominating) importance. A brief review concerning the physiological significance of body calcium and the mode of action of these two hormones is presented as an introduction to the basic philosophy of the study. A theoretical quasi-linear lumped-parameter model is developed to describe variations in ionic calcium, parathormone and calcitonin plasma concentrations to specific input stimuli. Formal evaluation of the system response requires the determination of ten constants, together with quantitation of ingested calcium entry into the plasma compartment which isindependent of hormonal influences. Values for various parameters are deduced from published data and experimental procedures are outlined to facilitate determination of the remaining unknowns. It is suggested that the proposed model should prove useful for investigations concerning general hormonal actions on calcium homeostatic mechanisms in both normal and diseased states, with particular reference to calcitonin.
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    URL: http://dx.doi.org/10.1007/BF02476710
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  • 20
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    The struggle for life: III. A predator-prey chain (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 521-532 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Ann species predator-prey chain is analyzed to determine what oscillations occur in population sizes. It is found that only the populations of the first and second species in the chain must necessarily oscillate around the point of equilibrium if they do not come to equilibrium. The other species may or may not oscillate.
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    URL: http://dx.doi.org/10.1007/BF02476712
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  • 21
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    Mathematical models for exchange of substances in regional vascular beds— Measurement of the rates within vivo counters (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 503-520 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Sangren and Sheppard developed a mathematical model for first-order processes taking place in the regional circulation, applicable—for example—to tracer studies of potassium transport. It permits calculation of specific activity at any point along a “tube of flow” or in the cuff of tissue surrounding it as a function of time following a spike injection of tracer. In efforts to relate to the exchange a rate curves obtained within vivo counters pointed at the region of interest, we developed a compartment-system model of the process. In investigating the properties of the Sangren and Sheppard model integrated over an entire circulatory bed, as thein vivo counter would see it, we found that when the distribution of transit times of the “tubes of flow” can be approximated by an exponential sum, the solution reduces to that of the compartment system model. This results in an important simplification in the calculation, and insight into the assumptions underlying the two different models. A curve-fitting computer program for the compartment model has been written and applied to double-isotope studies of potassium transport in the hind leg of the dog.
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    URL: http://dx.doi.org/10.1007/BF02476711
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  • 22
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    A numerical experiment on the determination of kinetic rate constants in the presence of diffusion (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 547-558 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Two chemicals,A andB, are allowed to diffuse together and a reaction described by $$A + B\mathop \rightleftharpoons \limits_{K_{ - 1} }^{K_1 } C$$ is allowed to proceed. This system is described mathematically by a system of partial differential equations. A numerical procedure is presented to find the rate constants ofK 1 andK −1. A systematic analysis of the effects of errors is also presented.
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  • 23
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    Observations on cardiac energetics: I. Theoretical introduction (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 533-546 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract Equations are developed to describe the energy expenditure of the human heart. As well as the external potential and kinetic energy terms, general consideration is given to other possible avenues of energy consumption. Emphasis is placed upon using mathematical variables which are readily available for experimental verification. The errors involved in assuming that mean values for the physiological parameters give reasonable estimations for the external mechanical performance are examined, and a theoretical estimation for the discrepancy in the kinetic component is presented. Logical extension of the mathematical derivation leads to a determination of cardiac external mechanical efficiency and clearly demonstrates the significance of the ventricular pressure-volume loop in this context. Finally, experimental procedures are suggested to clarify further some of the conclusions reached through the theoretical analysis.
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  • 24
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    Organismic sets. Sex in animal and human societies (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 559-563 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The question is discussed as to the reason why some animal societies, such as bees or ants, are sexually differentiated, that is, onlysome of its members are exhibiting reproducing activities. It is indicated that human society may be on its way to such a sexual differentiation which may eventually come.
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  • 25
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    Some biochemical threshold mechanisms (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 565-565 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
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    Announcement (1972)
    Springer
    Bulletin of mathematical biology 34 (1972), S. 567-567 
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    ISSN: 1522-9602
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    Topics: Biology , Mathematics
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  • 27
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    Stochastic models for an enzyme reaction in an open linear system (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 97-115 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract A stochastic model is developed for an enzyme reaction in an open linear system. The proposed model assumes that the open system maintains the concentration of substrate and inhibitor at constant levels and that the product molecules are removed from the system by a first order reaction. Stochastic models for several enzyme reactions occurring in this open system are shown to correspond to special cases of theGI/M/∞ queue. Takács’ (1958) results for this queueing system are used to obtain the stochastic properties of the enzyme systems. A specific model we studied assumed completely competitive inhibition in an open system. The stationary distribution for the number of product molecules in the system is obtained. The enzyme reaction which incorporated the “intermediate chain hypothesis” can also be investigated by the queueing theory approach. It is shown that for this open system, if the model which incorporated the intermediate chain hypothesis has the same deterministic properties as the Michaelis-Menten model, then the latter has greater stochastic variation than the former.
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    URL: http://dx.doi.org/10.1007/BF02476668
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    International Conference on Stochastic Point Processes (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 153-153 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
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    URL: http://dx.doi.org/10.1007/BF02476671
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  • 29
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    An integral method for the analysis of blood flow (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 117-128 
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    ISSN: 1522-9602
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Mathematics
    Notes: Abstract The existing methods to solve the problems of pulsatile flow in the cardiovascular system are based on either linear axisymmetric equations or non-linear one-dimensional equations. The solutions thus obtained give only a mediocre comparison with measurements. In this paper, a non-linear axisymmetric theory is proposed. The starting point of the present theory is a third degree polynomial representation of the velocity profile. Integral methods are then applied to obtain the governing equations. To ascertain the accuracy of the theory proposed above, the calculations for a simple case involving pulsatile flow in a long rigid tube were performed. The results are: (a) the average velocities compare very well with exact solutions and (b) the velocity profiles for a given frequency agree very well with exact solutions for flow in small tubes, but tend to differ as tube size is increased.
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  • 30
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    Methode d’objectivation d’organisations temporelles privilégiées d’activités neuronales unitaires (1971)
    Springer
    Bulletin of mathematical biology 33 (1971), S. 129-151 
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    Notes: Résumé Le but de ce travail est la mise en évidence d’éventuels “patterns” temporels privilégiés de potentiels d’action neuronaux masqués par la superposition d’une activité aléatoire. Dans la première partie, on propose un modèle susceptible de rendre compte de cette activité aléatoire. Dans la seconde, on expose une méthode d’extraction des patterns privilégiés, compatible avec les paramètres du modèle neuronal proposé. Son algorithme fait notamment intervenir l’estimation de la fonction d’expectation. Cette méthode peut, en fait, ment intervenir l’estimation de la fonction d’expectation. Cette méthode peut, en fait, être appliquée à l’étude de séries temporelles d’événements dans des domaines très divers.
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    International Symposium on Mathematical Biology (1971)
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    Bulletin of mathematical biology 33 (1971), S. 155-156 
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    Molecular set theory. III: The wide sense kinetics of molecular sets (1971)
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    Bulletin of mathematical biology 33 (1971), S. 355-372 
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    Notes: Abstract An effort is made to begin widening the scope of kinetics by merging the concepts and point of view of molecular set theory with the stochastic approach to kinetics, beginning with the simplest unimolecular molecular set transformation. In this spirit the new concept ofmolecular set variable is introduced as the basic unit of kinetics as opposed to simply the traditionalconcentration (or cardinality) unit, connoting that the composition as well as the size of a molecular set are significant dynamic features of a system. The changes in state (or “value”) of the molecular set variable are characterized by a Markovian stochastic process and the relationship between this process and the corresponding unimolecular process for the concentration variable introduced earlier is discussed. The possible role of molecular set theory in terms of the underlying biomathematical structure of relational biology is also considered.
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    Contribution a l’etude de la forme des plantes: discussion d’un modele de ramification (1971)
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    Bulletin of mathematical biology 33 (1971), S. 387-401 
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    Notes: Abstract The problem of the forms of plants and models of branching are discussed using experimental data on the mistletoe. The number of branches by division, the distribution of divisions with regard to the number of branches per division and to the level of division, the geometrical characters of branches according to the level of division and the host, the stability of model are studied. One gives an interpretation of the model of branching as a model of growth.
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    A quantum model for controlled enzymic reactions (1971)
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    Bulletin of mathematical biology 33 (1971), S. 373-386 
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    Notes: Abstract A quantum model for the general enzymic reaction,E+S ⇌ ES → P, is presented, starting with the assumptions that any chemical substanceS, which may be a substrate for a particularE (S)-enzyme is a microphysical system and any enzymeE-molecule, capable of interacting with anS-substrate is a “measuring system” which will “measure” one or more of theS-observables. According to the above assumptions a stochastic model of the reaction is constructed and a computer simulation of the steady state performed. The results thus obtained predicted fluctuations in the enzymic reaction rate, function of the substrate “perturbation”. On an experimental basis it is demonstrated that the irradiation of an enzymic substrate with low energies results in the inducement of a dose-dependent oscillatory behavior in the corresponding enzymic reaction rate. In the reaction type, the oscillations thus induced in theE-activity by the corresponding substrates are out-of-phase, realizing a biochemical discriminating net. Likewise, in an $$S_1 \xleftarrow{{E_1 }}S\xrightarrow{{E_2 }}S_2$$ reaction type, the oscillations induced by the irradiatedS-substrate in the activities of the respective enzyme, realize a biochemical switching net.
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    The myocardium as a composite material: Analysis (1972)
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    Bulletin of mathematical biology 34 (1972), S. 173-204 
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    Notes: Abstract As a further attempt to determine the stresses and strains of the individual myocardial fibers, the heart muscle is considered as an orthotropic material. A theory is presented which leads to the expression of the equilibrium conditions for the left ventricle in the form of three simultaneous differential equations. Solution of these equations would give the changes in shape of the left ventricle throughout the cardiac cycle, and, in addition, the stresses and strains of the individual myocardial fibers. It is pointed out, however, that meaningful solutions of the equations cannot be obtained at the present time because of difficulties in experimental determination of certain parameters.
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    A note on epilepsies and similar disorders (1972)
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    Bulletin of mathematical biology 34 (1972), S. 213-222 
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    Notes: Abstract This paper compares two previously published neural models for epilepsies (Bull. Math. Biophysics,33, 539–553, 1971;34, 71–78, 1972). The second model is developed in more detail and an attempt is made to bring it more in line with established neurological findings. The question of classification of some epilepsies is briefly discussed.
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    Suggestions for a mathematical model of a pathological neuron with spontaneous repetitive discharges (1972)
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    Bulletin of mathematical biology 34 (1972), S. 223-230 
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    Notes: Abstract A formal mathematical model is proposed for a spontaneously repetitively firing neuron. It is based on the assumption that an excitatory and inhibitory substance, possibly different from those involved in synaptic transmissions, is formed in the soma of everynormal neuron. Furthermore, the decay of the substances is ascribed to their combination with some other substances, present in healthy individuals. A generalized two factor system of differential equations is used. It is shown that when the normally present substances are absent, possibly due to genetic defects so that the decay constants become zero, the equations lead to undamped sinusoidal solutions of the difference between excitatory and inhibitory factors, thus producing a trulyspontaneous repetitive discharge, in the absence of external currents or other stimulation. It is suggested that convulsants may act by destroying the substances present in healthy individuals. It is further suggested that by administering to epileptics those substances, which are present in normal healthy persons, perhaps by using brain extracts fromhealthy higher animals which sometimes suffer from epilepsy, an actual cure rather than symptomatic treatment by anticonvulsants may be obtained.
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    Structure and kinetic behavior of linear multicompartment systems (1972)
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    Bulletin of mathematical biology 34 (1972), S. 277-291 
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    Notes: Abstract The general kinetic behavior of a multicompartment system is shown to depend upon certain general structural features, including its connectivity, whether it is open, and whether it contains cyclic pathways. Structural influences are clarified by putting the system matrix in a certain form. For systems not strongly connected, a distinction is drawn between partially and completely open systems. Necessary and sufficient conditions are given for non-singularity of the system matrix and for asymptotic stability of the system. Sufficient conditions are given for non-overshooting and monotonic transitions. A system is demonstrated whose solution may contain a prolonged series of damped oscillations; but the oscillations are very slow and small; and it seems unlikely that oscillations could be detected experimentally in any biological system.
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    A dynamical approach to chemical kinetics: Mass-action laws as generalized Riccati equations (1972)
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    Bulletin of mathematical biology 34 (1972), S. 243-275 
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    Notes: Abstract It is shown how the fundamental laws of chemical kinetics for either open or closed systems with an arbitrarily large number of reactants can be represented as a system of Riccati-like differential equations. Through the use of a concise tensor notation, it is shown when and how the differential system is exactly reducible to linear form, a reduction without approximation that parallels the well-known similar reduction of a single simle Riccati equation. An example is worked out to show how open kinetics can lead to oscillatory chemical concentrations of the Change-Higgins type. The biologically central problem of great chemical speciation is discussed from the viewpoint of Gibbs ensemble theory within the linearized kinetics and, approximately, within the starting nonlinear kinetics where it is shown roughly how to estimate, from an overall temperature-like parameter characterizing the whole system, mean chemical levels and mean frequencies of oscillation, and where a gross oscillation of the total mass is estimated in terms of an anharmonic oscillator whose general structure is fixed from the structure of the chemical kinetic laws.
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    Note on oscillations in a closed chain of compartments with linear, unidirectional transport (1972)
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    Bulletin of mathematical biology 34 (1972), S. 293-296 
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    Notes: Abstract A closed chain of compartments in which there is unidirectional transport between adjacent members can exhibit damped oscillations. For a system ofn equivalent compartments, the value ofn which gives the greatest difference between the first maximum and first minimum isn=11, the difference being 1.57%. The greatest difference between the first maximum value and the steady state value is 4% and is obtained whenn=25. The results are illustrated graphically forn equal to 5, 10, 25 and 100.
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    Pourquoi deux sexes? (1972)
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    Bulletin of mathematical biology 34 (1972), S. 297-304 
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    Notes: Abstract This paper is a concrete approach to the problem of the number of the sexes. We try to imagine—on the example of three sexes—the mechanisms which would have to accompany a reproduction with several sexes. We have limited our study to the monohybridism, dihybridism and determinism of the sex.
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    Cilia transport (1972)
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    Bulletin of mathematical biology 34 (1972), S. 325-335 
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    Notes: Abstract An analysis of the effect of cilia on fluid transport in tubules is presented. The applicability of the results for the flow rates observed in the ductus efferentes of the male tract is discussed.
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    Quantitative comparison of dipole models for steady-state currents in excitable membranes (1972)
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    Bulletin of mathematical biology 34 (1972), S. 305-324 
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    Notes: Abstract The dipole models for steady-state currents in excitable membranes of Arndt, Bond and Roper and of Hamel and Zimmerman are compared by fitting the equations to the data of Gilbert and Ehrenstein. The more complex Hammel and Zimmerman model does not fit the data as well as does the simpler Arndt, Bond and Reper model. When fitting the data, the Hammel and Zimmerman current equation reduces to the Arndt, Bond and Roper current equation because of the values assumed by the parameters. An interpretation is given for the parameter values obtained with the Arndt, Bond and Roper model.
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    On the decomposition of a dynamical system into non-interacting subsystems (1972)
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    Bulletin of mathematical biology 34 (1972), S. 337-341 
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    Notes: Abstract It is shown that, under rather general conditions, it is possible to formally decompose the dynamics of ann-dimensional dynamical system into a number of non-interacting subsystems. It is shown that these decompositions are in general not simply related to the kinds of observational procedures in terms of which the original state variables of the system are defined. Some consequences of this construction for reductionism in biology are discussed.
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    Self-reproduction and serial message transfer: Two related problems (1972)
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    Bulletin of mathematical biology 34 (1972), S. 343-353 
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    Notes: Abstract For a certain class of physical machines, termed “structure-determined,” the problem of self-reproduction can be reduced to the problem of serial message reproduction. Serial message reproduction however presupposes a sort of “open system” constraint. This leads to the principle of pseudo, or exogenously standardized, respectively, self-reproduction. It seems to be consistent with both chemical and biological self-reproduction. It thus may reflect a general principle of biological design. The proposed principle is a physico chemical analog to Robert Rosen's abstract relational self-reproduction constraint.
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    Active muscle fiber as an equivalent cardiac current generator (1972)
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    Bulletin of mathematical biology 34 (1972), S. 355-377 
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    Notes: Abstract Equations are derived describing potentials due to an active muscle fiber in an infinite medium in terms of two surface integrals—one of the propagated action potential and the other of the membrane current density, both integrals being taken over the surface of the muscle. These equations are incorporated into an equivalent cardiac current generator in which the left ventricle (i.e. the current source) is represented by a three-dimensional wedge and the thorax (i.e. the volume conductor), by a homogeneous circular cylinder. Since this current generator expresses the body surface potentials in terms of the membrane current density and the membrane potential at any point on the surface of the electrically active muscle fiber, the calculated ECG can be correlated with theactual sources within the heart. This equivalent cardiac generator possesses many of the physical and physiological properties of cardiac muscle. The equations were evaluated numerically on a digital computer. The results indicate that equivalent cardiac current generators of this type can yield clinically significant results and that further research is necessary to investigate their properties fully.
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    Analytical solutions for transient thermal behavior in biological systems (1972)
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    Bulletin of mathematical biology 34 (1972), S. 413-418 
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    Notes: Abstract Analytical solutions are presented for transient heat conduction in biological media. General boundary conditions and internal sources varied in both spatial and time variables are considered, thus, solutions for many special cases can be obtained with ease from the general solutions presented in this analysis.
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    Simultaneous diffusion and convection in single breath lung washout (1972)
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    Bulletin of mathematical biology 34 (1972), S. 393-412 
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    Notes: Abstract Two mathematical models of pulmonary single breath gas washout (one analytic, one numerical) are developed and their predictions compared with experimental data on human subjects. Weibel's 23 generation symmetric anatomical model is used as a guide to bronchial tree geometry. Experimental plots of nitrogen concentration versus volume expired, dead space versus breath holding time, and dead space versus tidal volume are compared with plots predicted by the models. Agreement is good. A plot of nitrogen concentration in the airways as predicted by the numerical model at different times during inhalation and exhalation of a single breath of oxygen is shown. Model predictions for changes in dead space with changes in washout gas and expiratory flow rate are discussed. Use of the analytic model for obtaining average values of the path length from mouth to alveoli in a given subject is discussed. To the extent of their agreement with experiment, the models provide a sound physical basis for the correlation of airway structure and function.
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    Announcement (1972)
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    Bulletin of mathematical biology 34 (1972), S. 429-429 
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    Generalizations of the Roginsky-Zeldovich (or Elovich) equation for charge transport across biological surfaces (1972)
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    Bulletin of mathematical biology 34 (1972), S. 419-427 
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    Notes: Abstract The Roginsky-Zeldovich (or Elovich) equation, which is −dx/dt=m exp (nx) (x=substrate concentration,t=time,m andn=constants), describes the kinetics of various biological electron and ion transport processes, and has been derived from the concept of charge transport across an activation energy barrier at an interface between dissimilar phases, driven by a difference in redox or ion potentials, with the simplifying assumptions that charge carrier concentration is constant, backward current across the interface is zero, and diffusion of substrate is fast. If charge carrier concentration is proportional to substrate concentration, then the kinetic equation is −dx/dt=mx exp (nx). If backward current is not zero, then −dx/dt=m 1 exp (n 1x) −m 2 exp (n 2 x), wherem 1,m 2,n 1 andn 2 are constants. Kinetic equations for interfacial charge transport in the presence of a significant substrate diffusion potential are also derived.
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    Basic studies on metabolic steady state. Incompletely mixed systems (1971)
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    Bulletin of mathematical biology 33 (1971), S. 403-412 
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    Notes: Abstract This paper is the second of a pair dealing with some mathematical properties of metabolic steady state. An investigator wishing to compute the rate of appearance and/or disappearance of a metabolite in steady state within an intact biological system will usually appeal to a method involving radioactive tracers. It is shown that while the investigator’s choice of the mode of tracer administration (constant infusion or single injection) is largely arbitrary, the mathematical interpretation of the results may depend upon the presence or absence of gradients in certain of the variables of the system. The latter will be the case if the system is sampled at a point within the distribution space of the metabolite which is not a source point but is otherwise arbitrary. In order to deduce a formula which gives the required rate, he must have knowledge of the gradient of concentration of the traced substance, and sometimes of the gradient of specific activity.
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    Some mathematical aspects of the medical diagnostic process. I: a general mathematical model (1971)
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    Bulletin of mathematical biology 33 (1971), S. 413-424 
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    Notes: Abstract Making a medical diagnosis consists of correlating knownpatterns of disease with the various classes of clinical data elicited from the history, physical examination, and batteries of tests relative to the diagnostic dynamics symbolized by atree branching into the various possible diagnostic decisions. In this paper a relational mathematical model of the reasoning aspects of the conventional medical diagnostic process is suggested as a way of extracting a general, formal concept of medical diagnosis. Computer implementation of the model is discussed briefly.
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    Forecasting and chronic illness (1971)
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    Bulletin of mathematical biology 33 (1971), S. 425-437 
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    Notes: Abstract Biomedical data in the form of series of observations made on a single process at regular intervals constitute a discrete time series and are eligible for time series methods of analysis. The models yielded by this analysis provide the framework within which exponential smoothing methods may operate on the data to provide recurrent forecasts of future states of the process. Because the forecasts may be made on an individual basis and are sensitive to the past behavior of the individual process, the methods are presented as being potentially of great utility in the management of chronic and progressive illnesses. When incorporated into automated testing and diagnostic systems, the forecasting method will provide the capability of making prognoses for large numbers of individuals, quickly, routinely and reproducibly.
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    The determination of cell-cycle parameters from measurements of the fraction of labeled mitoses (1972)
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    Bulletin of mathematical biology 34 (1972), S. 1-12 
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    Notes: Abstract A method is described for estimating cell-cycle parameters from experimental fraction-of-labeled-mitoses measurements. The method is closely related to that of J. C. Barrett (1970) but is based on the analysis of Brockwell and Trucco (1970) which takes into account population growth in the calculation of theoreticalFLM-functions. Several sets of experimental data are analyzed, among them the data for the Marshall tumor considered by Barrett. It is found that population growth has a small but nevertheless detectable effect on the estimates of the cell parameters.
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    Transfer times across the human body (1972)
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    Bulletin of mathematical biology 34 (1972), S. 33-44 
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    Notes: Abstract The radioactivity disappearance curves of glucose-6-14C albumin-I131 after a single injection of tracer into a human subject have been determined in detail, particularly at early time intervals. The curves, expressed as sums of exponentials, have been analyzed as the infinite sum of convolutions of single passage time densities. The resultant transfer time distribution of a single circulatory pass allows examination of all delays in the system no matter how long they take. The structural detail evident by this means and the long mean time of a single pass of glucose (〉5 min) supports the thesis that factors other than rapid and uniform diffusion play a role in the extravascular movements of glucose molecules.
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    A bisexual multitype branching process with applications in population genetics (1972)
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    Bulletin of mathematical biology 34 (1972), S. 13-31 
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    Notes: Abstract A bisexual multiple branching process is studied. Consider a population with respect to three genotypes in both the female and male populations and let $$X(n) = \left\langle {X_1 (n), X_2 (n), X_3 (n)} \right\rangle and Y(n) = \left\langle {Y_1 (n), Y_2 (n), Y_3 (n)} \right\rangle$$ be random vectors giving the number of females and males (respectively) of each genotype in generationn. The mating of females and males is accommodated in the model withZ ij (n) representing the number of females of theith genotype mated with a male of thejth genotype in generationn. The mating system is such that a female may be mated to only one male but a male may be mated with more than one female. By arranging the nine random variablesZ ij (n),i, j=1, 2, 3, in a 1×9, vectorZ(n) it is shown that under certain conditions there is a positive constant ϱ such that when ϱ〉1 the vectorsZ n /ρn,X n /ρn andY n /ρn converge almost surely asn→∞ to random vectors with fixed directions. The paper is divided into four sections. In section 1 the model is described in detail and its potential applications to population genetics are discussed. In section 2, the generating function of the transition probabilities of theZ-process are derived. Section3 is devoted to the study of the limiting behavior of the first and second moments of theZ-process, and in section4 the results of section3 are utilized to study the behavior of the random vectorsZ(n),X(n) andY(n) asn→∞.
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    Theory of initial current density in membrane voltage-clamp experiments (1972)
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    Bulletin of mathematical biology 34 (1972), S. 45-52 
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    Notes: Abstract Herein we show that the voltage-clamp current density at zero time calculated from electrodiffusion equations is linear in the clamping voltage for a simple membrane (no charge structure) and for a membrae with fixed charges. Such membranes are nonexcitable. Excitable membranes can be represented by a homogeneous membrane with dipole layers at the surface. In this case the initial current density will be linear in the clamping voltage if a critical field for a dipole layer reorientation is not passed through in changing from holding to clamping potential. Otherwise, deviation from nonlinearity may occur. This is in agreement with experimental data for the squid giant axon.
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    A note on sporadic nonperiodic oscillations in the activity of the endocrine system and on the endocrine—Nervous system feedback (1972)
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    Bulletin of mathematical biology 34 (1972), S. 65-69 
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    Notes: Abstract By generalizing a previous paper on periodicities in the endocrine system (Bull. Math. Biophysics,30, 735–749, 1968), it is shown that nonperiodic, sporadic oscillations in the system are also possible. A procedure of describing the feedback mechanism between the endocrine system and the central nervous system is suggested. It is shown that the combined system: endocrine—CNS, also may show sporadic fluctuations.
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    Wall shear in pulsatile flow (1972)
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    Bulletin of mathematical biology 34 (1972), S. 79-86 
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    Notes: Abstract This paper deals with a mathematical attempt to determine the wall shear during normal flow of blood in the ascending and the descending thoracic aorta. A simple model is used, but the results obtained are in agreement with published experimental results for the descending thoracic aorta. It is suggested that the degree of fluctuation in the pressure gradient at a given station is the major factor in determining the level of wall shear at that point.
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    A neural circuit which exhibits some features of epileptic attacks (1972)
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    Bulletin of mathematical biology 34 (1972), S. 71-78 
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    Notes: Abstract A neural model based on a generalization of a model proposed in 1938 in the first edition of the author'sMathematical Biophysics (Chicago: Univ. of Chicago Press) is described. It possesses the property that due to some endogenous or exogenous stimulus, which may be of random nature, a pathway may suddenly begin to fire spontaneously. This spontaneous firing may either gradually spread over other pathways and eventually cease, or it may remain localized within one or a few pathways and then cease. Which of the two types of events occurs depends on the values of a number of parameters. The case of spreading reminds one of Jacksonian epilepsy.
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    Diffusion exchange between a membrane-bounded sphere and its surrounding (1972)
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    Bulletin of mathematical biology 34 (1972), S. 93-102 
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    Notes: Abstract The diffusion equation is solved for a membrane-bounded sphere situated in an infinite medium with different diffusion properties. The formal solution is obtained through Laplace transformation in the time variable. It is not possible to find a closed form solution in terms of analytical functions, and therefore a numerical inversion technique is applied to obtain the final solution. The application on a biological problem is discussed.
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    Determination of reaction rate constants in the mammillary system (1972)
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    Bulletin of mathematical biology 34 (1972), S. 87-92 
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    Notes: Abstract It is shown that the individual rate constants can be determined for the composite chemical system: $$A + B_i \rightleftarrows C_i ; i = 1...N$$ with only measurements of the unbound species,A(t), required. The dissociation rate constants can be determined by direct analysis of a single steady state tracer study. The association constants then follow from the analysis of stable equilibrium determinations reported earlier (Hart, 1965). An approximate solution when tracer methods are in-applicable is also given.
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    Some biochemical threshold mechanisms (1972)
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    Bulletin of mathematical biology 34 (1972), S. 103-112 
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    Notes: Abstract Certain arrangements of enzymatic (bimolecular) subsystems lead to characteristic threshold-type response. Two simple cases of such systems are studied here in terms of steady state behavior and explicit relationships between system and curve parameters. It is found that the curvature of the threshold curve is directly related to the equivalent Michaelis constant and, in the case of saturated threshold curve, the slope of the curve at the idealized threshold is limited by the ratio of saturation to threshold. This slope may be appreciably increased up to a stepwise response at the threshold if a multisubstrate complex of the enzyme is the only species which affects the enzyme mediated transport.
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    Theory of neural mediation of intraocular dynamics (1972)
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    Bulletin of mathematical biology 34 (1972), S. 113-148 
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    Notes: Abstract Many experimental studies have indicated that the intraocular pressure is subject to mediation by adrenergic mechanisms affecting both the rate of formation of the aqueous humor and the resistance of the pathway through which the aqueous humor flows out of the eye. Thus, for example, the role of adrenergic drugs in glaucoma therapy is well known. How the mediation is accomplished has not been clarified in detail. Several possible mechanisms have been suggested, and all may indeed be involved. The present study is concerned with the basis and mathematical formulation of one of them and the consequences with respect to aqueous dynamics. The analysis leads to expressions for the aqueous outflow resistance and the formation rate, as well as other quantities of interest. The theoretical behavior is shown to compare favorably with the results of infusion studies and various other experiments, and to provide a unified picture of much of the pressure-flow behavior of both the living and the dead eye.
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    Eighth International Congress of Electroencephalography and Clinical Neurophysiology (1972)
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    Bulletin of mathematical biology 34 (1972), S. 149-150 
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    A fit to nerve membrane rectification curves with a double-dipole-layer membrane model (1972)
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    Bulletin of mathematical biology 34 (1972), S. 151-172 
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    Notes: Abstract Following Wei's suggestion that nerve stimulation and conduction properties are due to dipole layers at the two membrane surfaces (Wei, 1969), we have done steady-state electro-diffusion calculations in the constant field approximation for a simple double-dipole-layer model. We are thereby able to quantitatively fit the recent potassium iso-osmotic rectification curves of Gilbert and Ehrenstein for the squid giant axon membrane. For the squid axon membrane in a natural ion environment, only the outside dipole layer is present in the fit to the data.
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    Geometrical parameters of the individual myocardial fibers (1972)
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    Bulletin of mathematical biology 34 (1972), S. 205-211 
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    Notes: Abstract In this paper the left ventricle of the heart was considered as a shell of varying thickness. The first and second fundamental forms of the middle surface, of the shell, as well as Euler's theorem were used for deriving expressions giving the length and curvature of the individual myocardial fibers. Recent anatomical studies have shown that the myocardial fibers in the middle of the left ventricular wall follow a course nearly parallel to the horizontal plane (Streeteret al., 1969). In previous papers (Voukydis 1969, 1970) a mathematical description of the curvature and length of the individual myocardial fibers was presented. Unfortunately, both the curvature and the length formulas contained the cotangent of the fiber helix angle, which approaches infinity as the fiber assumes a course parallel to the horizontal plane. Consequently, these two formulas cannot be used for fibers nearly parallel to the horizontal plane. The present paper will give an alternative way for calculating the length and curvature of the individual myocardial fibers, based on the fundamental forms of surface and on Euler's theorem.
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    Some remarks on the central nervous system (1972)
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    Bulletin of mathematical biology 34 (1972), S. 231-242 
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    Notes: Abstract It is pointed out that the successes obtained in the mathematical biology of the central nervous system are based mostly on a number of more or less complicated neuronic circuit models, each inventedad hoc for the purpose of explaining a given phenomenon. The individual models remain disconnected from each other, however, and the unity of the CNS is not apparent. (Rashevsky,Mathematical Biophysics, 3rd Edition, Vol. II, 1960. New York, Dover Publications, Inc.) Some “field theories” of the CNS, as for example that of Griffith (Bull. Math. Biophysics,25, 111–120, 1963;27, 187–195, 1965), give more expression to this unity but lose in the explanation of specific phenomena. The present paper starts with the picture thatevery neuron in the brain isdirectly or indirectly affected to some extent byevery other neuron. This leads to a system of equations with a very large number of variables. Such a system can be replaced in the limiting case by an integral equation of the first kind. At least two specific results can be obtained with this approach and suggestions for further improvement are made.
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    Fiber stress profiles in the left ventricle of the heart during diastole: Effects of distension and hypertrophy (1972)
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    Bulletin of mathematical biology 34 (1972), S. 379-392 
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    Notes: Abstract Pressure-volume and volume-dimensions relationships, obtained from excised dog left ventricles were used for calculating the stresses acting along the longitudinal axis of the individual myocardial fibers. The calculations were based on a set of empirical and theoretical equations. The pressure-volume relationship as well as the volume-dimensions relationships for the excised left ventricle were expressed in the form of empirical equations; the fiber orientation was written as a function of the fiber location within the left ventricular wall; finally, the fiber stress was determined by means of theoretically derived formulas. Simultaneous solutions for the fibers of a meridian cut through the left ventricular myocardial shell were obtained by means of a digital computer and presented in the form of diagrams. The results showed that at low degrees of distension of the left ventricle there are two zones of higher stresses at the equatorial area, one near the epicardium and one near the endocardium. As the distension proceeds under the effect of progressively increasing intraventricular pressure, these two zones become less well defined, whereas a new zone of higher stresses appears near the apex. At high degrees of distension, the ventricle assumes a more spherical shape and the equatorial zones of higher stresses are replaced by zones of lower stresses. Increase in the myocardial mass results in appearance of the equatorial lower stress zones at lower degrees of distension.
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    Chorioretinal temperature increases from solar observation (1971)
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    Bulletin of mathematical biology 33 (1971), S. 1-17 
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    Notes: Abstract Chorioretinal temperature increases produced by solar observations are computed digitally. The spectral characteristics of solar radiation and the spectral transmittances of the atmosphere, atmospheric water vapor and ocular media are considered. Image spread is employed in all calculations. The calculations are executed for a variety of observation angles, and the effects of pupil diameter, fixed filters and optical instruments are predicted. Temperature increases are also computed for solar eclipse observations by the appropriate superposition of unobscured solar disk solutions.
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    The kinetics of diffusion between a spherical cell and a surrounding medium with different diffusion properties (1971)
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    Bulletin of mathematical biology 33 (1971), S. 19-26 
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    Notes: Abstract The diffusion equation according to Fick’s law is solved for a spherical cell, surrounded by an infinite medium with different diffusion properties. The method of Laplace transform is used to obtain the formal solution, however, no inversion can be found for all times and an expansion suitable for small times is performed. The final expression found is expanded further to be more suited for the determination of the diffusion coefficient from an experimental curve. Application to a biological problem is dissussed.
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    A mathematical model for first degree block and the Wenckebach phenomenon (1971)
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    Bulletin of mathematical biology 33 (1971), S. 27-38 
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    Notes: Abstract A simple mathematical model of first and second degree heart block is developed on the assumption that eachR wave, with its associated ventricular contraction, results in the release of a substance which raises the excitation threshold of the conducting tissue lying between theS-A andA-V nodes. The conduction pathway is represented by a chain of excitatory elements, the first member of which is acted upon by a regularly occurringP wave. The rate constant of the removal of this inhibitory substance, i.e., recovery rate, is the only constant necessary to be varied in order to pass from normal to first degree block to second degree. In this latter case one can predict the progressive increase inP-R interval until anR wave is missed, as occurs in the Wenckebach phenomenon. The model indicates that an increasedP wave frequency which would have little effect on theP-R inerval for a normal individual with rapid recovery, could produce a Wenckebach pattern in an individual with even a mild first degree block.
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    Temperature dependence of the Elovich equation derived from activated electron or ion transport across a biological interface, with an application to muscle spindle adaptation (1971)
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    Bulletin of mathematical biology 33 (1971), S. 39-47 
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    Notes: Abstract The temperature dependence of the Elovich equation, which is−dx/dt=m exp (nx) (wherex is concentration of substrate or ion,t is time, andm andn are coefficients dependent upon temperature), has been derived from the hypothesis of electron or ion conduction across an activation energy barrier at the surface of a biological particle or membrane, driven by a difference in redox or ion potentials. Using the additional hypothesis of reversible, temperature-dependent, inactivation of sites of reduction or complexing, the theory predicts that both coefficientsm andn have linear Arrhenius plots, in agreement with experimental data for gas adsorption on inorganic solid surfaces, and with two studies of muscle spindle adaptation.
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    Some recent results inn-person game theory (1971)
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    Mathematical programming 1 (1971), S. 58-67 
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    Notes: Abstract The discussion will center mainly on some work on two solution concepts: the core for gaines without side payments and the nucleolus for games with side payments (characteristic funtion games). The core has become an important equilibrium concept in mathematical economics. The nucleolus is related to the theory of bargaining sets.
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    Publications (1971)
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    Mathematical programming 1 (1971), S. 117-120 
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    The Mathematical Programming Society (1971)
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    Mathematical programming 1 (1971), S. 123-125 
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    Hybrid programs: Linear and least-distance (1971)
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    Mathematical programming 1 (1971), S. 153-167 
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    Notes: Abstract We consider a quadratic program equivalent to the general problem of minimizing a convex quadratic function of many variables subject to linear inequality constraints. In previous work [12], one of us presented an algorithm related to such problems, and classified them under “combinatorial equivalence”. The classification contained linear programs at one end (where the function has zero quadratic part) and least-distance programs at the other. A least-distance program is a problem of finding a point of a convex polyhedron which is at least distance from a given point; such programs have been studied by one of us [15, 17] and were shown to correspond to that case of the general problem where the function has positive definite quadratic part. We now extend the work on least-distance programs to those programs intermediate between linear and least-distance (called “essentially bisymmetric” in [12]), and show that such programs are really “hybrids”, with traits inherited from both parent programs: linear and leastdistance.
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    An “out-of-kilter” algorithm for solving minimum cost potential problems (1971)
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    Mathematical programming 1 (1971), S. 275-290 
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    Notes: Abstract An algorithm is given for solving the optimum potential problem, which is the dual of the classical “out-of-kilter” algorithm for flow problems. Moreover, a new proof of finiteness is provided, which holds even for non-rational data; it applies to all the algorithms of network theory which include a labeling process.
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    Mathematical programming 2 (1972), S. 130-132 
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    An algorithm for solving linearly constrained optimization problems (1972)
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    Mathematical programming 2 (1972), S. 133-165 
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    Notes: Abstract An algorithm for minimization of functions of many variables, subject possibly to linear constraints on the variables, is described. In it a subproblem is solved in which a quadratic approximation is made to the object function and minimized over a region in which the approximation is valid. A strategy for deciding when this region should be expanded or contracted is given. The quadratic approximation involves estimating the hessian of the object function by a matrix which is updated at each iteration by a formula recently reported by Powell [6]. This formula enables convergence of the algorithm from any feasible point to be proved. Use of such an approximation, as against using exact second derivatives, also enables a reduction of about 60% to be made in the number of operations to solve the subproblem. Numerical evidence is reported showing that the algorithm is efficient in the number of function evaluations required to solve well known test problems.
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    Maximal domains of quasi-convexity and pseudo-convexity for quadratic functions (1972)
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    Mathematical programming 3 (1972), S. 178-192 
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    Notes: Abstract We study quasi-convex and pseudo-convex quadratic functions on solid convex sets. This generalizes Martos' results in [12] and [13] by using Koecher's results in [8].
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    A partitioning algorithm for the multicommodity network flow problem (1972)
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    Mathematical programming 3 (1972), S. 157-177 
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    Notes: Abstract A partitioning algorithm for solving the general minimum cost multicommodity flow problem for directed graphs is presented in the framework of a network flow method and the dual simplex method. A working basis which is considerably smaller than the number of capacitated arcs in the given network is employed and a set of simple secondary constraints is periodically examined. Some computational aspects and preliminary experimental results are discussed.
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    Editorial policy (1972)
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    Mathematical programming 3 (1972), S. 396-396 
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    Homotopies for computation of fixed points (1972)
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    Mathematical programming 3 (1972), S. 1-22 
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    Notes: Abstract Given a point to set mapf on a simplex with certain conditions, an algorithm for computing fixed points is described. The algorithm operates by following the fixed point as an initially affine function is deformed towardsf.
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    On the basic theorem of complementarity (1971)
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    Mathematical programming 1 (1971), S. 68-75 
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    Notes: Abstract Using a fixed point theorem of Browder, the basic existence theorem of Lemke in linear complementarity theory is generalized to the nonlinear case.
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    An example of an ill-conditioned nlp problem (1971)
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    Mathematical programming 1 (1971), S. 113-116 
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    Matroids and the greedy algorithm (1971)
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    Mathematical programming 1 (1971), S. 127-136 
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    Notes: Abstract Linear-algebra rank is the solution to an especially tractable optimization problem. This tractability is viewed abstractly, and extended to certain more general optimization problems which are linear programs relative to certain derived polyhedra.
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    Penalty function versus non-penalty function methods for constrained nonlinear programming problems (1971)
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    Mathematical programming 1 (1971), S. 217-238 
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    Notes: Abstract The relative merits of using sequential unconstrained methods for solving: minimizef(x) subject tog i (x) ⩾ 0, i = 1, ⋯, m, h j (x) = 0, j = 1, ⋯, p versus methods which handle the constraints directly are explored. Nonlinearly constrained problems are emphasized. Both classes of methods are analyzed as to parameter selection requirements, convergence to first and second-order Kuhn-Tucker Points, rate of convergence, matrix conditioning problems and computations required.
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    Discrete optimization on a multivariable boolean lattice (1971)
    Springer
    Mathematical programming 1 (1971), S. 301-306 
    Details
    ISSN: 1436-4646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Notes: Abstract Consider the problem of finding the minimum value of a scalar objective function whose arguments are theN components of 2 N vector elements partially ordered as a Boolean lattice. If the function is strictly decreasing along any shortest path from the minimum point to its logical complement, then the minimum can be located precisely after sequential measurement of the objective function atN + 1 points. This result suggests a new line of research on discrete optimization problems.
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    URL: http://dx.doi.org/10.1007/BF01584094
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    Referees 1971 (1971)
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    Mathematical programming 1 (1971), S. 376-376 
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    ISSN: 1436-4646
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science , Mathematics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01584099
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  • 91
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    Über die Nullstellenbestimmung bei näherungsweise berechneten Funktionen (1972)
    Springer
    Computing 10 (1972), S. 23-31 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract Rounding errors which are inevitably made during the evaluation of a function by a computer lead to the problem of calculating zeros of an approximately computed function. We describe some methods generating simultaneously lower and upper bounds for zeros including all round-off errors automatically. A comparison with running error analysis [19] is given.
    Notes: Zusammenfassung Betrachtet wird die Aufgabe der Nullstelleneingrenzung von nur näherungsweise berechenbaren Funktionen. Dazu werden Verfahren verwendet, welche sowohl die unvermeidlichen Rundungsfehler als auch Ungenauigkeiten in den Ausgangsdaten automatisch miterfassen. Nach einer Beschreibung der zugrundeliegenden Methoden wird ein Vergleich mit anderen bekannten Vorgehensweisen, insbesondere mit running error analysis [19], gezogen.
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    URL: http://dx.doi.org/10.1007/BF02242380
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  • 92
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    Algorithmus zur Bestimmung von Abständen in endlichen, gerichteten und unbewerteten Graphen (1972)
    Springer
    Computing 10 (1972), S. 107-109 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract Given a graph by a node-node-matrix. One finds the distanced ij of two nodesP i andP j by using binary operations between the rows of the node-node-matrix.
    Notes: Zusammenfassung Ein Graph sei gegeben durch seine Knoten-Knoten-Matrix. Den Abstandd ij von zwei KnotenP i undP j des Graphen bestimmt man mit Hilfe von binären Verknüpfungen der Zeilen der Knoten-Knoten-Matrix.
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    URL: http://dx.doi.org/10.1007/BF02242385
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  • 93
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    Automatic a priori round-off analysis (1972)
    Springer
    Computing 10 (1972), S. 97-106 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Zusammenfassung Der Effekt der Rundungsfehler in einem algebraischen Prozeß wird oft mit einer sogenannten Rückwärtsanalyse untersucht. Wir wollen hier die Möglichkeit untersuchen, diese Analyse auf einem Computer auszuführen. Wir beginnen mit einer genauen Definition eines stabilen Algorithmus, oder aber eines Algorithmus der relativ unempfindlich auf Rundungsfehler reagiert.
    Notes: Abstract The effect of rounding errors on an algebraic process is often investigated by means of a so-called backward analysis. In this paper we will discuss the possibility of performing such an analysis on a computer. We begin with a precise definition of a stable algorithm, i.e., an algorithm which is relatively insensitive to rounding errors.
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    URL: http://dx.doi.org/10.1007/BF02242384
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  • 94
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    Normalformen planarer Graphen (1972)
    Springer
    Computing 10 (1972), S. 137-152 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242388
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  • 95
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    Über Pivot-Strategien bei der Lösung linearer Gleichungssysteme (1972)
    Springer
    Computing 10 (1972), S. 167-175 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract When solving linear equations with elimination methods, pivotal strategies are used to improve numerical precision. In this paper some new pivotal strategies are suggested and compared with known strategies by means of numerical experiments.
    Notes: Zusammenfassung Bei der Lösung linearer Gleichungssysteme mit Eliminationsmethoden verwendet man Pivot-Strategien zur Steigerung der numerischen Genauigkeit. In dieser Arbeit werden einige neue Pivot-Strategien vorgeschlagen und mit bekannten Strategien an Hand numerischer Experimente verglichen.
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    URL: http://dx.doi.org/10.1007/BF02242391
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  • 96
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    Buchbesprechungen (1972)
    Springer
    Computing 10 (1972), S. 189-190 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02242393
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  • 97
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    Dynamische Optimierung zur allgemeinen Spline-Approximation mit Ungleichungsnebenbedingungen und Anwendung auf Optimierungsberechnungen beim Entwurf von Straßen (1972)
    Springer
    Computing 10 (1972), S. 191-204 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract A coherence is pointed out between a general spline-approximation and the dynamic programming. In this way it is possible to construct a numerical method for the solution of complicated approximation problems. For instance eachLp-approximation including the Tschebyscheff-approximation problem may be solved regarding inequality constraints between the element parameters of the spline function and varying the generally fixed spline knots. Moreover it is possible to treat more general problems arising from optimisation calculations during the design of roads.
    Notes: Zusammenfassung Es wird ein Zusammenhang hergestellt zwischen einer verallgemeinerten Spline-Approximation und der dynamischen Optimierung. Dadurch ist es möglich, ein numerisches Verfahren zur Lösung von komplizierten Approximationsaufgaben anzugeben. Beispielsweise läßt sich damit jedeLp-Approximation einschließlich der Tschebyscheff-Approximation numerisch behandeln unter Berücksichtigung von Ungleichungsnebenbedingungen zwischen den Elementparametern der Spline-Funktion und unter Freigabe der üblicherweise festgehaltenen Spline-Knoten. Darüber hinaus lassen sich dadurch allgemeinere Aufgaben lösen, die bei Optimierungsberechnungen während der Entwurfsbearbeitung von Straßen auftreten können.
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    URL: http://dx.doi.org/10.1007/BF02316907
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  • 98
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    Über allgemeine Gaußsche Quadraturen (1972)
    Springer
    Computing 10 (1972), S. 83-95 
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    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract As well known, Gauss-quadrature formulas are constructed by integration of suitably choosen Hermitian interpolating polynomials. At first, a general linear interpolating operator and its error-term are given. Integrating this operator, one yields quadrature formulas containing some first derivatives of the integrand-function. By the requirement, that the weights of these derivatives should vanish all together, we get general quadrature formulas of Gauss-type. For some special basic functions of the interpolating operator, vanishing of the weights of the derivatives is necessary for minimization of the quadrature error. The general Gauss-quadratures may be determinated algebraically if sufficiently many fix-elements of the interpolating operator are known. As special cases one has, besides the known usual Gauss-quadratures and Wilf's quadrature procedure, a very surprising result.
    Notes: Zusammenfassung Die Gaußschen Quadraturformeln erhält man bekanntlich durch Integration geeignet gewählter Hermitescher Interpolationspolynome. Zunächst wird hier ein allgemeiner linearer Interpolationsoperator mit Restglied angegeben. Durch Integration dieses Operators erhält man Quadraturformeln die neben Funktionswerten auch Werte der 1. Ableitung des Integranden enthalten. Fordert man, daß die Gewichte dieser Ableitungswerte sämtlich verschwinden, so erhält man allgemeine Gaußsche Quadraturformeln. Bei speziellen Arten von Basisfunktionen des Interpolationsoperators ist das Verschwinden der Gewichte der Ableitungswerte notwendig für die Minimierung des Quadraturrestes. Die allgemeinen Gaußschen Quadraturformeln lassen sich bei Kenntnis von hinreichend vielen Fixelementen des Interpolations-operators auch algebraisch herleiten. Als Sonderfälle erhält man neben der bekannten gewöhnlichen Gauß-Quadratur das Wilfsche Quadraturverfahren, ein sehr überraschendes Ergebnis.
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    URL: http://dx.doi.org/10.1007/BF02242383
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    Normalformen planarer Graphen (1972)
    Springer
    Computing 10 (1972), S. 121-136 
    Details
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract In Part I is shown, how to decompose a connected graph into triply connected components in a canonical manner and how to compute a standard form of an arbitrary graph from standard forms of triply connected graphs. Hence, in part II a method is given, which allows to construct a standard form of triply connected planar graphs. Besides that, an ALGOL-program is presented which realizes both this method and a planarity criterium.
    Notes: Zusammenfassung In Teil I wird gezeigt, wie ein zusammenhängender Graph in kanonischer Weise in dreifach-zusammenhängende Komponenten zerlegt werden kann, und wie man aus Normalformen dreifach-zusammenhängender Graphen Normalformen beliebiger Graphen erhält. In Teil II wird dann eine Methode zur Gewinnung von Normalformen dreifach-zusammenhängender Graphen dargestellt. Außerdem wird ein ALGOL-Programm angegeben, das diese Methode sowie ein Planaritätskriterium realisiert.
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    URL: http://dx.doi.org/10.1007/BF02242387
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  • 100
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    Über Struktur und Abschätzungen der Lösungsmenge von linearen Gleichungssystemen mit Intervallkoeffizienten (1972)
    Springer
    Computing 10 (1972), S. 231-244 
    Details
    ISSN: 1436-5057
    Source: Springer Online Journal Archives 1860-2000
    Topics: Computer Science
    Description / Table of Contents: Abstract In this paper an intervalanalytic generalization of the theorem ofPrager-Oettli is used to characterize the solution-set of an, n-system of linear equations with interval coefficients as union of convex polyhedra with special properties. Then it is shown how to deduce from the theorem ofPrager-Oettli a nearly optimaln-interval contained in the solution-set. On the other hand the problem of finding with reasonable expense sharpn-intervals containing the solution-set is solved only for special cases. Some results on this problem are discussed; a numerical example shows the importance of criteria, under which sharpn-intervals can be computed with reasonable effort.
    Notes: Zusammenfassung In der vorliegenden Arbeit wird mit Hilfe einer intervallanalytischen Verallgemeinerung des Satzes vonPrager-Oettli die Lösungsmenge von Intervallgleichungssystemen als Vereinigung von konvexen Polyedern mit speziellen Eigenschaften charakterisiert. Anschließend wird gezeigt, wie sich aus dem Satz vonPrager-Oettli brauchbare Innenabschätzungen der Lösungsmenge ableiten lassen. Dagegen ist das Problem, möglichst scharfe Außenabschätzungen mit vertretbarem Aufwand zu bestimmen, vorerst nur unter gewissen Voraussetzungen gelöst. Einige Ergebnisse zu diesem Problem werden diskutiert; ein numerisches Beispiel verdeutlicht die Bedeutung von Kriterien, unter denen scharfe Außenabschätzungen mit vertretbarem Aufwand berechnet werden können.
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    URL: http://dx.doi.org/10.1007/BF02316910
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