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  • Springer  (62,250)
  • 1980-1984
  • 1965-1969  (57,049)
  • 1925-1929  (5,201)
  • 1968  (32,184)
  • 1965  (24,865)
  • 1928  (5,201)
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  • 1980-1984
  • 1965-1969  (57,049)
  • 1925-1929  (5,201)
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  • 1
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    Bulletin of mathematical biology 30 (1968), S. 1-1 
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  • 2
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    Bulletin of mathematical biology 30 (1968), S. 27-32 
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    Notes: Abstract In a previous paper (Bull. Math. Biophysics,29, 565–574, 1967) the author developed equations to represent velocity and hematocrit profiles in quasi-Poiseuille flow of blood. It was assumed that energy dissipation was minimized and that the viscosity depended on hematocrit and shear rate according to the Casson formula. These equations are simplified considerably, placed in a form more suitable for numerical solution and shown to depend on a single dimensionless parameter. Typicalin vivo values for this parameter are calculated.
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  • 3
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    Bulletin of mathematical biology 30 (1968), S. 33-46 
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    Notes: Abstract In this paper, discrete models of reproduction are studied. In part one, definitions are given, particularly on order of the reproduction; part two concerns the growth of the population; part three, the phenomena of delay or acceleration; and part four, the consequences of mortality.
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    Bulletin of mathematical biology 30 (1968), S. 3-26 
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    Notes: Abstract A model of the regulation of thyroid hormone in the bloodstream of living systems is formulated and analyzed. The portion of this model defined as theregulator includes components representing the thyroid, anterior pituitary and hypothalamic organs and their intercommunicating channels, that is, the peripheral plasma and hypophysial portal circulations and certain neuro-secretory connections. The loss of hormones from the plasma in the living system associated with physiological mechanisms within the peripheral tissue space and the excretory pathways is represented in the model by a lumpedload on the regulator. The model is reduced to a system of differential equations involving eleven parameters and variables, all of which are identified with certain physiological structures and states. Five of these are currently observable by available laboratory techniques and two others are computable explicity from the equations of the model; the remaining four can be computed in the same way to within a multiplicative constant. Procedires for carrying out ten of these measurements and calculations are suggested. On the basis of the equations and parameters of the model, a discussion of the normal behavior and the response of this system to certain types of disturbances is presented. A systematic effort has been made in the development of this model to include all relevant physiological data and relationships reported in the biological literature. A summary of this literature, reflecting the views and interpretations made by the authors of this paper, is included for completeness and ease of reference.
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    Bulletin of mathematical biology 30 (1968), S. 47-59 
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    Notes: Abstract In this paper an expression is derived which describes the transient overall uptake of an inert solute by a section of tissue excised with parallel faces and placed upon an impermeable base. The approach diverges from the conventional analyses for perfused tissue (Morales and Smith,Bull. Math. Biophysics,6, 125–141, 1944;7, 47–99, 1945) because the extravascular zone is regarded as a heterogeneous diffusion medium. Account for this is taken by regarding tissue as effectively composed of two phases—a continuous (extracellular) phase similar to water, and a dispersed phase comprising cells of irregular profile. In both phases the relevant mode of uptake is taken as bulk diffusion rather than surface permeation, thus emphasizing the influence of the internal geometry of the tissue upon its overall exchange response.
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    Bulletin of mathematical biology 30 (1968), S. 87-104 
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    Notes: Abstract A method for the identification of flow systems by frequency domain analysis has been extended to include systems with recirculation and truncated data curves. Application of the technique to clinical indicator-dilution curves indicates that the method may be useful in the quantitation of intracardiac shunts. A number of numerical examples which demonstrate the accuracy of the method are included.
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    Bulletin of mathematical biology 30 (1968), S. 61-86 
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    Notes: Abstract By assigning time-varying coordinates to all environmental stimuli, it has been possible to axiomatize psychoanalytic theory on the five principles of multiple causation, growth-aging influence, genetic influence, historic influence and conscious-unconscious activity. The theorems of summation of response and the inevitability of conscious-unconscious conflict with their corollaries follow directly from the axiomatic foundations, as does the existence of an adaptation-defense mechanism. The interpretation of the defense mechanism in terms of an ego-id feedback system provides the basis for the structural existence of conscious-conscious and unconscious-unconscious conflict.
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    Bulletin of mathematical biology 30 (1968), S. 117-122 
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    Notes: Abstract In previous studies of (M,R) (Rosen, 1961; Demetrius, 1966), it was assumed that changes in the structure of (M,R) which were induced by environmental alternations occurred without error. Here, the effect of both “genetic” and “metabolic” malfunctions on the behavior of (M,R) is examined and a subclass of these systems whose behavior is invulnerable to such errors is specified.
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    Bulletin of mathematical biology 30 (1968), S. 105-116 
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    Notes: Abstract The definition of an (M,R) is formulated in a way that emphasizes its mathematical properties. Neglecting interactions between the components, it is shown that: (1) An (M,R) contains only one non-reestablishable component. (2) If an (M,R) contains only one non-reestablishable component, then that component is central. Examples are given to illustrate the biological significance of these two results. The notion of “lag-independence” is introduced, and it is shown that if a system possesses only one non-reestablishable component which is “lag-independent” then all components are lag-independent. The concepts of reestablishability, centrality and lag-independence are applied in order to suggest various criteria for optimal organization of (M,R).
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    Bulletin of mathematical biology 30 (1968), S. 123-133 
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    Notes: Abstract A mathematical representation for the analysis of control mechanisms in biochemical reactions is presented. First, the theoretical concept of concentration in biological systems is developed. Then a system consisting of two functions λ and τ is constructed as a network of single output automata. The range of λ is taken to be formed by a set of twostates qualitatively different from the “repair function” Φ f of a mappingf: A→B in the stimulated Φ1 and unstimulated state Φ0. Likewise, the range of τ is formed by the set δ={f o ,f 1} wheref 1 means the mappingf in its stimulated state andf o in the unstimulated one. It is demonstrated that the mathematical structure described acts as a control mechanism over thef and Φ f , so that two biochemical components,A→B, are transformed at a controlled rate. Some of the biological applications of this model are briefly examined. The Jacob-Monod model, the enzymatic adaptation phenomenon, and the “rheon unit” hypothesis are discussed within our framework. Eventually, a concrete model for the RNA-polymerase mechanism, based on the above discussion, is presented.
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    Bulletin of mathematical biology 30 (1968), S. 135-151 
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    Notes: Abstract The application of Rashevsky’s transformationT to a primordial graph yields a set of graphs corresponding to different stages in the development of the organism. However, sinceT is multiple-valued the graphs obtained are not ordered. To obtain an ordering, it is first shown that the set of graphs under consideration is equivalent to a well defined setO (for “organism”) ofn-tuples. A metric is then introduced which is based on a biological consideration discussed by Rashevsky (Bull. Math. Biophysics,16, 317–348, 1954). Since a metric implies an ordering of the setO, with a knowledge of the structure of the primordial, one can obtain the developmental sequence. Unfortunately, at present, the structure of the primordial graph is unknown which makes the direct application of the above principle impossible. Consequently, an indirect approach which makes use of more accessible biological phenomena is discussed as well. The hypothesis thatrate of development decreases exponentially and the implications this has with regard to the metric onO are discussed. It is shown that if the hypothesis is accepted the search for the developmental sequence is narrowed.
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    Bulletin of mathematical biology 27 (1965), S. 49-63 
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    Notes: Abstract Compartmental systems can be represented by direct graphs in which each node corresponds to a generating function and each arm to a transfer generating function. A homomorphism is established between a compartmental system and this representation, in analogy with that obtained through the use of the Laplace transformation. From the values obtained experimentally in a given compartment, through the solution of a difference equation, the generating function for the corresponding node can be calculated and the graph of the system can be built up within the degrees of freedom of the model. From the graph it is possible to calculate the transfer generating function between any two connected nodes, the mean permanence time in a given node, the mean transit time between two nodes, and their precursor-successor order.
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    Bulletin of mathematical biology 27 (1965), S. 85-89 
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    Notes: Abstract The Competitive Exclusion Principle, formulated by V. Volterra (Memorie del R. Comitato Talassografico Italiano,131, 1–142, 1927) for a number of species competing for a common ecological niche, is extended to a number of species competing for many ecological niches.
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    Bulletin of mathematical biology 27 (1965), S. 65-70 
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    Notes: Abstract A modification is presented of an earlier theory of the mixing of dye following injection into the circulation. Approximate theoretical relations are given for the concentration of dye in the right heart and in the aorta following right atrial injection. It is shown that when the probability distribution of transit times around the circulation has a prolonged tail, mixing waves are now inscribed about a quasi-exponential relation. Later in time the relation levels off to a uniform asymptotic concentration corresponding to an equilibrium volume of dilution.
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    Bulletin of mathematical biology 27 (1965), S. 91-104 
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    Notes: Abstract The adsorption of two cations at the anionic sites of a polymer (e.g., such as a protein) in an electric fields is discussed, taking into account cooperative interaction of the cations mediated through the backbone of the polymer. The calculation of the grand partition function explicitly considers the vacant negative sites of the polymer. As in the case without cooperative interaction, the problem reduces to the determination of the largest eigenvalue of asymmetric matrices. The weights of the different neighbor configurations are determined. Approximate formulae for the grand partition function and for those weights are derived. The formal analogy of these cooperative phenomena and those occurring in quantum (bio)chemistry is pointed out exemplifying an earlier suggestion about the basis of quantum biology.
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    Bulletin of mathematical biology 27 (1965), S. 105-112 
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    Notes: Abstract The transformation from gel to sol in cell cytoplasm is treated as the transition from a lattice of macromolecules linked by Ca++ ions to a random distribution of the macromolecules. The transition is a cooperative process, whose probability is expressed in terms of the theory of runs. The process is related to cell metabolism by the assumption that available Ca++ concentration is regulated by metabolically produced endogenous chelating agents.
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    Bulletin of mathematical biology 27 (1965), S. 113-118 
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    Notes: Abstract Kinetic criteria for solid state physical mechanisms of electron and ion transport in biological systems are summarized, and the mechanisms are discussed. A reaction which is rate-limited by electron or ion transport across a particle or membrane in accord with Ohm's law will show first order kinetics, with an hyperbolic relationship between rate constant and the sum of substrate plus product. Larger initial substrate concentrations produce smaller rate constants, thus giving the appearance of substrate inhibition. Examples are cytochrome oxidase and peroxidase, and pyruvate carboxylase. Ohmic transport mechanisms may be caused by electron conduction or superconduction through protein, by electron conduction through water, or by conduction of ions through membranes. A reaction which is rate-limited by charge transport across an activation energy barrier at an interface in accord with a logarithmic voltage-current law will show reaction kinetics conforming to the Elovich equation, and will have the appearance of a pair of simultaneous first order processes. Examples include decay of photogenerated free radicals in eye melanin particles and in photosynthetic particles of bacteria, and sodium and potassium ion transport across cell surfaces. The logarithmic voltage-current law may be regarded as an empirical relationship describing behavior of interfaces, justified by extensive experimental data on many types of interfaces, or it may be derived theoretically for individual cases from statistical mechanical and/or solid state physical considerations.
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    Bulletin of mathematical biology 27 (1965), S. 119-130 
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    Notes: Abstract When aortic pressure curves were predicted previously on the basis of a newly developed model of visco-elastic properties of the aorta, it was necessary to use published viscoelastic constants. These were usually obtained from longitudinal strips of blood vessels long removed from the animal, and therefore probably containing deteriorated smooth muscle. The predicted curves had the same form as actual tracings, substantiating the analysis somewhat, but the pressure levels were low. These low levels, if due to inadequate visco-elastic constants, could be attributed to the use of longitudinal rather than circumferential segments as well as to the use of segments with deteriorated muscle. The present analysis uses data collected by the author testing circumferential viscoelastic properties of fourteen different aortic regions in a way suggested by the author's model of an aortic wall. Moreover, the constants were measured on segments containing muscle relaxed by EDTA solutions and on similar segments containing muscle contracted by neosynephrine. These visco-elastic constants were used in the author's nonlinear differential equation of motion of the aortic wallin vivo to predictin vivo pressure curves. The predicted curves were low in any given aortic region if relaxed constants were used, but at normal levels with contracted constants. In fact, pressure curves predicted using constants obtained from aortic segments containing contracted muscle resembled actual tracings in form and pressure levels. Even the observed variations in the form of the systolic pressure curve down the aorta were predicted by this analysis.
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    Bulletin of mathematical biology 27 (1965), S. 131-133 
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    Notes: Abstract It is an empirical finding that an allometric quantity with dimensional exponents α, β and γ relative to mass, length, and time, respectively, has a value for its allometric exponentb satisfying the relation $$\tfrac{1}{3}(3\alpha + \beta + {\gamma \mathord{\left/ {\vphantom {\gamma 2}} \right. \kern-\nulldelimiterspace} 2}) \leqslant b \leqslant \tfrac{1}{3}(3\alpha + \beta + \gamma ).$$ A theoretical derivation is given of this double inequality using only the fact of constant density and the plausible assumption that metabolic rate is a dominant allometric quantity.
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    Bulletin of mathematical biology 27 (1965), S. 135-143 
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    Notes: Abstract C. Shannon's definition (Bell System Technical Journal,27, 379–423, 1948) of the entropy of a continuous distribution is dimensionally incorrect and does not have the same significance as the corresponding definition in the discrete case. A new definition is proposed: this modified entropy is more like the entropy of a discrete distribution in one way, in another more like Shannon's “transmission rate.” The ideas are illustrated by reference to Wright's study of the hereditary influence on the coat pattern of the guinea pig.
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    Bulletin of mathematical biology 27 (1965), S. 145-150 
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    Notes: Abstract In the following paper, a possible mode of evolution is described which differs from the traditional modes in not being selective in the Darwinian sense.
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    Bulletin of mathematical biology 27 (1965), S. 177-181 
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    Notes: Abstract A description of the kinds of systems susceptible to information theoretical analysis is given. By means of an example, certain common fallacies in the application of communication theory to biology are illustrated. The entropy-information analogy is discussed. *** DIRECT SUPPORT *** A01E2109 00008
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    Bulletin of mathematical biology 27 (1965), S. 161-175 
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    Notes: Abstract A mathematical model of a process contains parameters supposedly characterizing the system which manifests the process. If the parameters are statistically distributed in a population of such systems, the process manifested by the entire population will in general be described by a different mathematical model. Thus a choice is always at hand between two or more mathematical models, depending on which parameters (if any) are assumed to be distributed and, if so, how. Examples of such alternative interpretations are given for mathematical models of some behavioral processes.
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    Bulletin of mathematical biology 27 (1965), S. 191-202 
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    Notes: Abstract The problem of economically linking a large number of stimuli with a large number of potential responses is considered to resemble a problem of efficient retrieval of documents (the responses) on the basis of their characterization by descriptors (the stimuli to which the responses are appropriate). In this retrieval problem, a method whereby the codes for descriptors are random positions in a coding field, and whereby codes for all applicable descriptors are superimposed in the same field, seems to be the simplest way of avoiding serious difficulties of retrieval. After a review of this method, the possibility is considered that very simple neural mechanisms could embody the essential features of the method. The aim of the discussion is to learn whether very simple structures and patterns of reinforcement would be adequate to carry out useful information processing in the brain, and to show some conceivable functions of simple neural networks which the experimenter might keep in mind. The discussion also shows how the structure of a simple “perceptron”-like network is suggested by the requirements of a retrieval task.
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    Bulletin of mathematical biology 27 (1965), S. 223-233 
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    Notes: Abstract A model is proposed to relate the regeneration of the ERGa-wave after partial light adaptation to the level of the light adaptation. The model assumes that thea-wave amplitude is a function of some reactive substance associated with ana-wave generator. The maximuma-wave amplitude occurs when the eye is fully dark adapted, and thea-wave generator initiator concentration is at a maximum. Thea-wave generator initiator concentration can be decreased by interacting with a product of the rhodopsin-light energy reaction, and increased by removal of this inhibitor. The removal of the inhibitor depends upon the isomerization of the all-trans-retinene to the 11-cis form. An excess of inhibitory material overa-wave generator initiator would cause a delay in the appearance of thea-wave until the excess inhibitory material is removed. This delay is a linear function of the logarithm of the adapting energy. The agreement of this model with the experimental ERG data is very good.
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    Bulletin of mathematical biology 27 (1965), S. 215-222 
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    Notes: Abstract The survival rate of fishes in their earlier stages of development and the influencing factors present one of the most fundamental problems of fish population dynamics. After I. Hjort's (Cons. L.'explor. Ner.,20, 3–228, 1914) work, there have been many investigators in this field and there is no doubt about the very important role of ova and larvae mortality in the fate of a given fish generation. Less clear are the ideas concerning factors determining the high mortality of fishes in their earlier stages of development; especially the factor of food supply of larvae during the period of transition to exogenic nutrition. The value of this factor has been estimated differently from different points of view. For example, R. J. H. Beverton and S. J. Holt (On the Dynamics of Exploited Fish Population, 1957) have given to the food supply factor its deserved importance. On the other hand, T. V. Dekhnik (Trudy Sevastopolskoi Biologicheskoi Stantsii,13, 216–244, 1960;Ibid.,14, 222–243, 1961) has proved in her investigations that at least for pelagic larvae of Black Sea fishes there is an excessive amount of food, and that therefore food cannot play an important role in larva survival. Not wanting to stop to review the literature of the problem (see Dekhnik,Trudy Sevastopolskoi Biologicheskoi Stantsii,13, 216–244, 1960), we will only remark that the problem as a whole needs further investigation. Not only new data are needed, but also methods for following up analysis have to be worked out.
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    Bulletin of mathematical biology 27 (1965), S. 253-259 
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    Notes: Abstract The investigation described here is anexperimental one which brings to light some new facts and confirms others already reported. They partly concern the hysteresis phenomena handled by N. Rashevsky (Mathematical Biophysics, 1960) and partly provide a point of departure for future biophysical research to be undertaken by biomathematicians.
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    Bulletin of mathematical biology 27 (1965), S. 27-52 
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    Notes: Abstract The aortic pressure curve necessarily reveals the mechanical properties of the aorta and peripheral resistance as well as of the dynamics of blood flow. The present study uses a reasonable model of visco-elastic properties of the aorta, a reasonable form for variations in peripheral resistance and blood flow to predict an aortic pressure tracing. Numerical values of constants measured experimentally were available in the published literature. These were used in the nonlinear differential equations of motion of the system under analysis. The equations yielded to piece-wise solution, giving the aortic circumference and the aortic pressure as functions of time. The form of both curves resembles clinical tracings, but numerical values of circumference were higher and of pressure lower thanin vivo. The discrepancies between predicted and clinical curves may reveal certain inadequacies in published measurements on visco-elastic constants. These measurements have been made on longitudinal rather than circumferential strips often containing dead rather than living muscle. The discrepancies, therefore, indicate specific gaps in our knowledge of aortic behaviorin vitro. The suggested model of the system aided in the design of experiments which could supply data necessary to substantiate or to revise the model.
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    Bulletin of mathematical biology 27 (1965), S. 373-377 
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    Notes: Abstract Some aspects of the circulation through the veins remain unexplained. The pressure gradient which ordinarily exists across a large vein, for example, is much greater than that necessary to maintain the same flow through a rigid tube of identical diameter (Brecher, 1956; Starling and Evans, 1962). During inspiration, blood flow through the thoracic portion of the inferior vena cava increases markedly, while that through the distal abdominal portion does not change. Furthermore, an active source of pressure drop in the chest is necessary to maintain venous flow. For the open chest the pressure drop occurs mainly during ventricular contraction, while in the closed chest it is produced chiefly by inspiration. The present study indicates that the high distensibility of the veins accounts in significant degree for the behavior characteristic of the venous circulation.
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    Bulletin of mathematical biology 27 (1965), S. 379-387 
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    Notes: Abstract This paper is an attempt to provide a logical model for the process of growth and differentiation in a multi-cellular organism. More specifically it is intended to show how genetic information relating to macroscopic structure and coded in the form of a logical tree could be progressively embodied in the organism as it develops by repeated division from a single cell. The aim is to establish biological analogies rather than mathematical interest, and reproduction, adaption, and the coordinating action of hormones are discussed within the general logical framework.
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    Bulletin of mathematical biology 27 (1965), S. 407-415 
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    Notes: Abstract Models having the form of surfaces of revolution may be used to represent the urethra under pre-voiding pressure. From such models are derived formulas for calculating muscle tension from the shape of a urethragram.
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    Bulletin of mathematical biology 27 (1965), S. 389-406 
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    Notes: Abstract The calculation of rates of entry of material into an open system of multiple pools in the steady state from the specific activities of end products, which may be derived from several pools, is described. This analysis may be applied to estimate the rates of secretion of steroid hormones from the specific activities of urinary metabolites which may have various hormones as common precursors. In a previous publication (Gurpideet al., 1963) formulae have been presented by which secretory rates could be calculated after a single injection of the tracers assuming that each of the urinary metabolites was uniquely derived from one of the pools in the system. In the present article similar formulae were derived without this assumption. Consequently, it is shown that, under certain circumstances, non-uniquely derived metabolites can be used to estimate secretory rates, and that it may be unnecessary to consider the pathways of conversion of the hormones to the metabolites or the sites where these conversion occur.
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    Bulletin of mathematical biology 27 (1965), S. 431-434 
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    Notes: Abstract The sensitivity and “specificity” of measurements for the determination of transferates are enhanced by the use of an additional radiotracer, serving to trace the unlabelled substance. This method presents advantages mostly in systems outside their steady state but only exeptionally in steady state systems.
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    Bulletin of mathematical biology 27 (1965), S. 417-429 
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    Notes: Abstract An integral equation approach to perturbation-tracer analysis in steady-state multicompartment systems is formulated. The theory is developed for δ function perturbation and tracer inputs and extended to the case of continuous small perturbations and continuous tracer inputs. It is shown that the first order dependence of the initial entry function can then be expressed by means of an integral equation: $$B_1 (t) = \int_{t_2 = - \infty }^\infty {\int_{t_1 = - \infty }^\infty {P(t_1 )T(t_2 )B_1 (t - t_2 ,t_1 - t_2 )dt_1 dt_2 } } $$ whereB 1(t) is the first order initial entry function for the tracer material,P(t1) the perturbation function.T(t 2) is the tracer input function, andB 1(t−t 2 ,t 1 −t 2 ) is a continuous function of two variables characterizing the first order perturbation-tracer response of the system.
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    Bulletin of mathematical biology 27 (1965), S. 435-447 
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    Notes: Abstract A correspondence is established between a tangible model of brain structure (and function) and a system of observer-observed interactions. The observed quantities are “stimuli” in the form of signal amplitude distributions in a mass of neuron-like units; the observer is a set of neurons (not circumscribed in a local region) in which a distributed parameter mirrors the stimulus history of the set, i.e., represents a “memory”. Utilizing the theory of the Perceptron, a contemporary brain model, it is demonstrated that large systems composed of many observer-observed interactions exhibit quantum mechanical behavior on a “macroscopic” scale. This behavior entails wave-like phenomena and the need of applying the superposition mechanics to system information content calculations.
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    Bulletin of mathematical biology 27 (1965), S. 449-471 
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    Notes: Abstract This is the continuation of Part I, which was published in the September, 1965, issue of theBulletin. The birth rate, α(t), is now assumed to be a linear functional of the age density,n. This gives a simple model of self-replenishing stem cell compartments, and leads to a necessary condition for the existence of a steady state. Some examples are presented to illustrate the formalism. They include: (a) An equivivant population with life spanD and no losses from death or migration. The total number of cells is multiplied by 2 in each time intervalD. As a special case, frequently realized in practice, the population may be increasing exponentially with time (“log-phase” of growth). (b) A compartment with “random” emigration of cells and gamma distribution of life spans. (c) An oversimplified version of L. G. Lajtha’s model describing stem cell kinetics. In section IV a simple case in which the loss function depends explicitly onn is discussed very briefly.
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    Bulletin of mathematical biology 27 (1965), S. 473-476 
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    Notes: Summary Mathematical models of nonuniform gas distribution in the lungs which assume a two-chambered lung to be ventilated through a third chamber, i.e. a common dead space, have led to diverging results. A breath-by-breath analysis of such a system results in a two-exponential solution whereas a continuous ventilation analysis gives a three-exponential solution. This is caused by the different assumptions made in the two models about the composition of dead space gas. In the breath-by-breath analysis one assumes that theN 2 content of the dead space is zero at the end of inspiration. In the continuous ventilation model one assumes that theN 2 content in the dead space is unknown at all instants during the breathing cycle. No physical significance should be attached to any chamber in this type of analysis. The continuous ventilation model provides a more general solution than the cyclical ventilation model, because the former treats the common dead spaces as an independent unknown.
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    Bulletin of mathematical biology 27 (1965), S. 493-495 
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    Bulletin of mathematical biology 27 (1965), S. 477-491 
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    Notes: Abstract The different approaches to relational biology developed by N. Rashevsky and R. Rosen consider essentially binary relations between various components of biological functions of the organism. Actually an organism is represented by a set of differentn-ary relations. The present paper is an attempt to outline a possible approach to this more realistic situation. Inasmuch asn-ary relation is ann-place predicate, it is attempted to describe the basic known properties of an organism in terms ofn-place predicates, in which the variables represent the different “components” of the organism. Some possible forms of such predicates are discussed and some general properties of systems of such predicates are studied. It is shown that if the organism is described by predicates of the type discussed here, statements can be derived about the conditions “of reestablishability” of different components. Conclusions similar to those obtained previously by R. Rosen are reached now on a very different basis. A description of the process of cell differentiation in multicellular organisms in terms of predicates studied here is briefly outlined. A comparison of similarities and differences between the approach and Rosen’s description of organisms in terms of the theory of categories is made.
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    Bulletin of mathematical biology 27 (1965), S. 497-500 
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    Bulletin of mathematical biology 27 (1965), S. 503-503 
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    Bulletin of mathematical biology 27 (1965), S. 501-502 
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    Bulletin of mathematical biology 27 (1965), S. 57-65 
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    Notes: Abstract An outline is given of an analysis that leads to an exact solution for the problem of steady-state diffusion through a finite thick pore into an infinite region surrounding the mouth of the pore. From this exact formula a simple expression for the flux is derived. This expression approximates the flux with a relative error of less than 3.42 per cent independently of the ratiol/a wherel is the length of the pore anda its radius. If desired, more accurate expressions for the flux can be obtained from the exact solution.
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    Bulletin of mathematical biology 27 (1965), S. 79-86 
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    Notes: Abstract The model proposed by A. L. Hodgkin and R. D. Keynes (Jour. of Physiol.,128, 61–88, 1955) for the diffusion of potassium through the nerve membrane is extended to cover an arbitrary number of species of ions with charges not necessarily the same. One type of interference is also investigated.
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    Bulletin of mathematical biology 27 (1965), S. 71-83 
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    Notes: Abstract Most theoretical studies of the circulation have focussed on the transmission line properties of arteries. Only a small number of papers have dealt with the circulation as a closed (lumped) system with two pumps connected by the lesser and greater circulation (Beneken, inCirculatory Analog Computers, No. Holland Publ. Co., Amsterdam, 1963; Defares,et al., inCirculatory Analog Computers, No. Holland Publ. Co., Amsterdam, 1963; Grodins,Quart. Rev. of Biology,34, 93, 1959; Guyton,Cardiac Output and its Regulation, Saunders Publ. Co., New York, 1963). F. W. Cope's recent studies in this journal (Bull. Math. Biophysics,22, 19, 1960;23, 337, 1961;24, 137, 1962) deal with essentially the same questions, although here the circuit is not “closed”. We have attempted to extend the analysis of the areflex (closed) circulation. The complete study is reported elsewhere (Defares,et al., Acta Physiol, et Parmac. Neerl., 1963).
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    Bulletin of mathematical biology 27 (1965), S. 67-78 
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    Notes: Abstract A vector integral equation describing heat distribution within the body has been derived. The factors considered are heat conduction, forced convection via the circulatory system, environmental exchange, metabolic heat production, and change in heat content. The vector partial differential equation and alternative forms incorporating boundary conditions were also developed. A difference equation based on a first-order approximation to the fundamental equations was derived to form the basis of a model for heat distribution within the body. It has been shown that factors involving conduction and convection must be considered independently unless the temperature of the blood flowing from a region of the body is equal to the average temperature of the tissue in that region. If this relation between tissue and blood temperature does exist, only a single temperature from each eleeent is needed to describe the heat distribution. In this latter case, models which ascribe all heat transfer to “equivalent” conduction or to convection can give valid predictions.
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    Bulletin of mathematical biology 27 (1965), S. 87-98 
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    Notes: Abstract It is shown that in a system containingn types of mutually noninteracting binding sites, the association constants are then roots of annth order polynomial while the maximum binding capacities can be evaluated by solving a set ofn simultaneous linear equations. Thenth order polynomial and the system ofn linear equations are defined in terms of 2n intermediate coefficients, the coefficients being themselves evaluated by substituting 2n sets of appropriate experimental data into an auxiliary system of 2n linear equations. The existence and uniqueness of the solutions are established.
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    Bulletin of mathematical biology 27 (1965), S. 111-111 
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    Bulletin of mathematical biology 27 (1965), S. 113-113 
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    Bulletin of mathematical biology 27 (1965), S. 99-109 
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    Notes: Abstract A kinetic theory of ion transport across cell surfaces has been developed in a form analogous to the kinetic theory of electron transport across solid-liquid interfaces of biological particles. The ionic theory is based on the observation that, at least in one instance, the voltage-current behavior for ion conduction across a cell surface is describable by the Tafel equation, in analogy to the conduction of electrons across solid-liquid interfaces. The theory predicts that the kinetics of ion transport across cell surfaces should conform to the Elovich rate equation, which is shown to be true for various experimental data.
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    Bulletin of mathematical biology 27 (1965), S. 114-114 
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    Bulletin of mathematical biology 27 (1965), S. 115-115 
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    Bulletin of mathematical biology 27 (1965), S. 3-4 
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    Bulletin of mathematical biology 27 (1965), S. 5-10 
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    Bulletin of mathematical biology 27 (1965), S. 11-14 
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    Notes: Abstract The present note consists of two separate but related parts. In the first, a new graphtheoretic proof is presented that an (ℳ,R)-system must always contain a nonreestablishable component. The second considers some questions concerning the relation between re-establishability and the time-lag structure in (ℳ,R)-systems. It is supposed that the reader is familiar with the terminology of the author's previous work on (ℳ,R)-systems, particularly R. Rosen,Bull. Math. Biophysics,20, 245–260, 1958.
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    Bulletin of mathematical biology 27 (1965), S. 21-37 
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    Notes: Abstract A simplified, linearized model of the system regulating blood-glucose concentrations is reviewed. This model, which predicts a damped sine wave response to an oral glucose load, lumps the large number of kinetic parameters into a much smaller number which can, at least in part, characterize the human glucose regulatory system. The predictions based on the model are compared with measurements of blood-glucose and blood-insulin concentrations during the oral glucose-tolerance test. Various other conditions are simulated and their implications are discussed in terms of the mathematical model used.
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    Bulletin of mathematical biology 27 (1965), S. 15-19 
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    Notes: Abstract The notion of a compartment is discussed in terms of the Markovian process. From the stochastic matrix (the elements of which are state transition probabilities between different states of a particle of a chemical element), one may find a (generally) nonstochastic matrix; the elements of this second matrix are probabilities that, starting from some initial state, the particle will reach another seleced state (W. Feller, 1962,An Introduction to Probability Theory). Forming equivalence classes of states it can be shown that the equivalence classes based on an equivalence relation, which holds for the elements of the above-mentioned nonstochastic matrix, are essential for the notion of a compartment. From this procedure it is also obvious that a rigorous definition of a physically realizable compartment is impossible. Some conclusions on the practical use of compartmental analysis are drawn.
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    Bulletin of mathematical biology 27 (1965), S. 39-48 
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    Notes: Abstract In a population of cells labeled with a single injection of tritiated thymidine at timet=0, it is assumed that a constant fraction, 1−z, of the cells which are potentially able to divide fail to do so, and that the cells which do divide all have identical generation time,D. Death and emigration of cells are neglected. In mitosis, the partitioning of label among the two daughter cells is supposed to follow the binomial probability law. Using the formalism developed by H. Von Foerster the fraction of labeled cells in the total population is computed as a function oft, the time after injection of label. Ift is an integral multiple ofD the results coincide with those of S. A. Tyler and R. Baserga.
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    Bulletin of mathematical biology 27 (1965), S. 151-160 
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    Notes: Abstract A society with a dominance relation is considered to be built up by starting with a small society and adding new members in succession. As each member is added he engages in contests with each of the older members to determine the dominance relation between them. The probability that the older member dominates is considered to depend on the size of the society and linearly on the older members score. A recurrence relation for the hierarchy index is derived. The approach of the society to a hierarchical structure is considered for various special cases of this probability. Reasonable assumptions concerning this dominance probability are shown to lead to structures close to the hierarchy. If the new member dominates all the older ones below a certain rank, and is dominated by all those above this rank, then the hierarchy will persist if it is the initial structure, or the structure will tend to hierarchy as the size increases, if it is not the initial structure.
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    Bulletin of mathematical biology 27 (1965), S. 183-190 
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    Notes: Abstract The transport of oxygen in a hemoglobin-saturated medium is theoretically investigated using classical transport theory. It is found that all the chemical complexes can be expressed as a single function of oxygen pressure. A potential difference together with apH shift is predicted to occur across the medium.
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    Bulletin of mathematical biology 27 (1965), S. 203-214 
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    Notes: Abstract Several physical effects (magnetomotive force on ions, magnetic induction of electrical field, magnetic changes of inductance) are quantitatively analyzed in an attempt to attain an insight on how externally applied static magnetic fields influence the activity of the neuron and the Nervous System as a whole or in part. The possible magnetic action on shifting excited zones of the axon appears as most promising for prediction and interpretation of measurable effects. Magnetic fields may modify nervous functions by multiplication and addition of very small biophysical effects.
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    Bulletin of mathematical biology 27 (1965), S. 235-251 
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    Notes: Abstract In an earlier paper (Molecular Set Theory: I.Bull. Math. Biophysics,22, 285–307, 1960) the author proposed a “Molecular Set Theory” as a formal mathematical meta-theoretic system for representing complex reactions not only of biological interest, but also of general chemical interest. The present paper is a refinement and extension of the earlier work along more formal algebraic lines. For example the beginnings of an algebra of molecular transformations is presented. It also emphasizes that this development, together with the genetical set theory of Woodger's and Rashevsky's set-theoretic contributions to Relational Biology, points to the existence of a biomathematical theory of sets which is not deducible from the general mathematical, abstract theory of sets.
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    Bulletin of mathematical biology 27 (1965), S. 261-273 
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    Notes: Abstract Systems in which a human subject interacts with an adaptive control mechanism through display and response facilities are examined. A cybernetic model is discussed, together with supporting experimental data.
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    Bulletin of mathematical biology 27 (1965), S. 275-290 
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    Notes: Abstract Computer simulation of the stem-cell system has been motivated by a desire to provide a device which may assist the experimenter in his development of complex research strategies in the rapidly developing investigative fields that relate to erythropoiesis and granulopoiesis. A simulation program, written in FORTRAN II for the IBM-7094, is being developed with the requirements of flexibility and broad applicability in mind. The biological model for which it originally was developed differs from those previously advanced by visualizing differentiation into the erythrocytic and granulocytic series as occurring during the post-mitotic phase of a stem cell's growth, the cell's susceptibility to erythropoietic and granulopoietic stimuli varying as its biochemical development unfolds. One might test this model by attempting to demonstrate an asymmetrical interference between erythropoietic and granulopoietic challenges to the stem-cell system. A method for establishing an initial stable configuration of the model is presented. The simulation of the introduction of exogenous erythropoietic stimuli is described. And there is a brief description of the feedback mechanism employed to stabilize the size of the stem-cell population.
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    Bulletin of mathematical biology 27 (1965), S. 305-310 
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    Notes: Abstract In a system as complex and as effective as the eye, the cooperative interaction of different mechanisms may be taken as axiomatic. With this as a starting point, various visual phenomena are considered, such as short term memory, eye movements, and flicker fusion. Simple data on mean values lend support to the proposition that the spatial and temporal characteristics of these phenomena are matched with one another. The significance of this for a mechanism of vision is discussed.
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    Bulletin of mathematical biology 27 (1965), S. 311-315 
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    Notes: Abstract Matrix algebra is the natural tool for the study of linear stochastic models with many parameters. Complete solutions are given for the nonconfluent and the general confluent cases. It is shown that the axiomatics of a generalized linear stochastic model are naturally described within the framework of the linear algebra in an Euclidean space.
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    Bulletin of mathematical biology 27 (1965), S. 291-303 
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    Notes: Abstract An arbitrary set of chemical reactions is considered to occur among chemical speciesX i . In a closed uniform reaction system certain linear combinations of the concentrations of theX i are constants. The general construction of all such linear combinations with non-negative coefficients is given in terms of the molecular formulae for theX i . It is shown that to each such linear combination there corresponds another which is a harmonic function when the reactions take place in an open spatially distributed stationary reaction system of arbitrary shape. Under the usual boundary conditions these harmonic functions are constants. With some restrictions upon the diffusion and permeability coefficients these constants are evaluated. This evaluation is the basis for relations between the total concentration of a given chemical group (e.g., the sum of the concentrations of a free molecule, or ion, and its various bound forms) in the reaction system, and in the surrounding medium. The bearing of these relations on apparent active transport is noted and illustrated.
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    Bulletin of mathematical biology 27 (1965), S. 329-332 
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    Notes: Abstract It is shown that the partitioned initial entry functions previously introduced in multicompartment analysis can be directly and uniquely determined from the experimental data.
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    Bulletin of mathematical biology 27 (1965), S. 317-328 
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    Notes: Abstract An escape learning situation is discussed in terms of a neural model in which a stimulus can result in a conditioned excitement and a specific conditioned response. By using the simplest relations between the strengths of conditioning and the number of reinforcements and by introducing a distribution of fluctuations occurring regularly in time, one can calculate the probabilities of various responses, as well as the various latencies, in successive trials. The results are in moderately satisfactory agreement with the data of R. L. Solomon and L. C. Wynne (Psychol. Monogr.,67, No. 4, 1953). Consequences of the model for various experimental situations are discussed.
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    Bulletin of mathematical biology 27 (1965), S. 1-8 
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    Notes: Abstract Collateral circulation minimizes the myocardial injury which results from narrowing of a coronary artery. A large collateral circulation has disadvantages, however. It may divert so much of the limited blood flow through the adjacent nonarteriosclerotic coronary artery that the blood supply of the normal muscle supplied by that artery may be inadequate during heavy exercise. In the presence of a large collateral circulation, both the normal and ischemic regions of the heart may be extremely vulnerable to small arteriosclerotic changes narrowing the patent artery near the aorta. The effective increase in flow which results from arteriolar vasodilatation produced by drugs may be much greater in the presence of a small collateral circulation than a large one.
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    Bulletin of mathematical biology 27 (1965), S. 9-20 
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    Notes: Abstract A transfusion can be hypothesized to be required when a determination factor (D=probability of adverse effects if transfusion not given/adverse effects if transfusion is given) exceeds some predetermined value.D varies between the limits 0 and ∞, and in most clinical situations will be a small number on the order of 20. Since the probabilities contributing to the denominator ofD are essentially independent of each other, they can be summed to obtain the probability of ill effects. A method of handling an exception to this, the incompatibility reactions following multiple transfusions within a short time interval, is pointed out. The probability of adverse effects if a transfusion is not given is more difficult to evaluate; values gathered from the literature are presented, as well as methods for obtaining further data. Two techniques for estimating future transfusion requirements are discussed. One is a correlative procedure, which functions by analyzing similar cases admitted to the hospital. The second procedure is an estimate of stability (homeostasis), based on a parameter introduced by B. C. Patten (Scince,134, 1010–1011, 1961). The dilution of endogenous cells and plasma by transfusions is considered and the consequences of many small transfusions compared with those of few (and larger) transfusions.
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    Bulletin of mathematical biology 27 (1965), S. 21-26 
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    Notes: Abstract In continuation of a previous paper (Bull. Math. Biophysics,26, 167–185, 1964) simple equations are derived for the rate of development of schizophrenia as a function of some psychobiological parameters of the individual and of an index which characterizes the frequency of traumatic experiences of the individual. A clue to the understanding of why schizophrenia is more likely to develop at an early adult age is thus provided.
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    Bulletin of mathematical biology 27 (1965), S. 53-56 
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    Notes: Abstract A mathematical analysis is presented which shows that during stop flow experiments longitudinal diffusion of solute along the nephron is of too small a magnitude to interfere with the interpretation of data.
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    Bulletin of mathematical biology 30 (1968), S. 153-162 
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    Notes: Abstract In a previous paper (Bull. Math. Biophysics,22, 257–262, 1960), an expression for the probability that a car jumps off a road as a function of the speed and the size of the car was derived mostly from geometric and kinematic considerations, introducing only the reaction time as a biological parameter. In subsequent papers (Bull. Math. Biophysics,29, 181–186, 187–188, 1967) a more detailed study was made of the exact shape of the tracking curve of the car which involved several biological parameters of the driver. In the present paper the results of the previous studies are combined, and a more general equation for the probability of jumping off the road is obtained. This probability, as in the earlier study, increases with the speedv, widths o and lengthl o of the car, and decreases with widths of the lane. However, this probability also depends on several parameters which characterize the psychobiological constitution of the driver. Unpublished experiments by Ehrlich, which corroborate the general conclusions, are briefly described.
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    Bulletin of mathematical biology 30 (1968), S. 205-213 
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    Bulletin of mathematical biology 30 (1968), S. 163-174 
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    Notes: Abstract The theory of organismic sets, developed in previous papers (Bull. Math. Biophysics,29, 139–152; 389–393; 643–647) is further generalized. To conform better with some biological and sociological facts the basic definitions are made more general. The conclusion is reached that every organismic setS o is in general the union of three disjoined subsetsS o1 ,S o2 andS o3 . Of these the subsetS o1 , called the “core” is equivalent to an organismic set defined in previous publications. Its functioning is essential for the functioning ofS o . The subsetsS o2 andS o3 , taken alone, are not organismic sets. The first of them is responsible for such biological or sociological functions which are not necessary for the “immediate” survival ofS o but which are important for adaptation to changing environment and are therefore essential for a “long range survival.” The second one,S o3 , is responsible for biological or social functions which are irrelevant for the survival ofS o . Biological and sociological examples ofS o2 andS o3 are given. In addition to the fundamental theorem established in the first of the above mentioned papers, three new conclusions are derived. One is that in organismic sets of order higher than zero not all elements are specialized. The second is that every organismic set of order higher than zero is mortal. The third is that with increasing specialization the intensities of some activities in some elements ofS o are reduced. Again the biological and sociological examples are given. At the end some very general speculations are made on the possible relation between biology and physics and on the possibility of “relationalizing” physics.
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    Bulletin of mathematical biology 30 (1968), S. 175-204 
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    Notes: Abstract The structural information content (Rashevsky, 1955; Trucco 1956a, b)I g (X) of a graphX is defined as the entropy of the finite probability scheme constructed from the orbits of its automorphism groupG(X). The behavior ofI g on various graph operations—complement, sum, join, cartesian product and composition, is examined. The principal result of the paper is the characterization of a class of graph product operations on whichI g is semi-additive. That is to say, conditions are found for binary operations o and ∇ defined on graphs and groups, respectively, which are sufficient to insure thatI g (X o Y)=I g (X)+I g (Y)−H XY , whereH XY is a certain conditional entropy defined relative to the orbits ofG(X o Y) andG(X) ∇G(Y).
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    Bulletin of mathematical biology 30 (1968), S. 215-224 
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    Notes: Abstract The mathematical treatment of three models of possible development of a society with a dominance relationship is discussed. The conclusion is reached that social factors as well as inherent characteristics need to be introduced to account for near-hierarchical structures. This is not a surprising conclusion; however, deriving it from mathematical considerations should be of interest to the mathematical sociologist since it puts the problem into theoretical perspective. Also these considerations may suggest quantitative observations or experimental tests and given indications as to their analysis.
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    Bulletin of mathematical biology 30 (1968), S. 291-298 
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    Notes: Abstract Some of the properties of the equations describing three species living in competition in the same environment are analysed. In particular it is found that, under certain conditions, the size of the three populations can oscillate.
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    Bulletin of mathematical biology 30 (1968), S. 299-308 
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    Notes: Abstract Expressions are obtained for the pulse velocities in cylindrical tubes of rubber-like materials which are under a state of initial stress. The development is based on the theory of finite elastic deformations and a Mooney materials is considered for illustrative purposes. Numerical results are given in terms of dimensionless parameters which involve the stretch ratio and lumen volume ratio. For the thoracic aorta, a value for the pulse velocity is obtained which is lower than the experimental value.
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    Bulletin of mathematical biology 30 (1968), S. 309-318 
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    Notes: Abstract A macroscopic conservation equation is derived for electromagnetophoresis of a dilute suspension. The governing equation and auxiliary conditions are formulated for transport in a rectangular cell, these being reduced to standard form by dimensional methods.
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    Bulletin of mathematical biology 30 (1968), S. 319-323 
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    Notes: Abstract The relationships between various size distributions in balanced exponential growth of a batch culture of microorganisms are presented. Starting from the partial differential integral equations (Eakmanet al., 1966; Fredricksonet al., 1967) derived for the growth of a microbial culture expressions are obtained for the growth rate of organisms of specific size and size range. These expressions were first obtained by Collins and Richmond (1962) by an entirely different method. Also derived are equations which link probability functions, which are basic to the growth of a microbial culture, with other size distributions that can be estimated experimentally.
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    Bulletin of mathematical biology 30 (1968), S. 325-331 
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    Notes: Abstract Under the assumption of simple Fick-law diffusion with convection and/or imposed force fields, the flux law for tagged molecules in a tracer system is derived, and the Sheppard-Householder interfusion coefficient identified. The partial differential equations for concentrations of tagged species and for specific activities in an open distributed reaction system are derived and compared.
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    Bulletin of mathematical biology 30 (1968), S. 333-340 
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    Notes: Abstract Two theorems relating to properties of the solutions of the equations of continuity for the concentrations of the chemical species in a diffusion-reaction system are proved. The theorems concern boundary conditions under which the flux of a specified species can be guaranteed to be directed into the reaction region and the circumstances under which any two of the conditions (i) stationarity, (ii) flux equilibrium, and (iii) chemical equilibrium, imply the third. Application of these theorems to apparent active transport and to the properties of the differential equations for specific activities in a distributed tracer system are noted.
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    Bulletin of mathematical biology 30 (1968), S. 341-349 
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    Notes: Abstract Recent experiments on so-called chemical transfer of memory may indicate at first glance that the possibility of transfer of the memory of a large number of reaction patterns in this manner requires the assumption of a correspondingly large number of specific chemical substances. It is shown that this is not necessarily the case. A mechanism is conceivable in which a single substance is responsible for “memory” transfer for a large number of distinct patterns. Mechanisms involving only about one hundred different specific substances could conceivably be responsible for chemical transfer of memory of some 1050 spatial patterns.
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    Bulletin of mathematical biology 30 (1968), S. 351-353 
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    Notes: Abstract It is suggested how nonoriented graphs may be used to representn-ary relations in organisms and to study the changes in variousn-ary relations under the transformation proposed in a previous paper (Bull. Math. Biophysics,16, 317–348, 1954).
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    Bulletin of mathematical biology 30 (1968), S. 355-357 
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    Notes: Abstract It is suggested that the development of organismic sets is governed not by the maximalization of the integral survival value, as suggested previously (Bull. Math. Biophysics,28, 283–308, 1966;29, 139–152, 1967;30, 163–174, 1968), but by maximizing the number of new relations which appear as an organismic set develops.
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    Bulletin of mathematical biology 30 (1968), S. 387-414 
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    Notes: Abstract The connection between the adjacency matrix and the automorphisms of a digraph is used to develop a method for studying the automorphism group and, thus, the information content (Mowshowitz 1968a, b) of a digraph. An algorithm is given for constructing digraphs with zero information content, and the properties of such digraphs are examined. Moreover, an algorithm for computing the automorphism group of a digraph is presented and is used to find conditions which insure that two digraphs have the same information content. This algorithm is further used to determine the information content of digraphs whose adjacency matrices have prescribed properties.
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    Bulletin of mathematical biology 30 (1968), S. 359-385 
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    Notes: Abstract The arterial system is characterized geometrically as a system of branched elastic fluid lines whose frequency response is then known in the sense of the Fourier transform. For convenience of visualization the transient response of the individual tube to an input pressure-flow pair is represented in the time domain by kernel functions indicating the hybrid effect of viscosity and momentum on the line impedance and damping characteristics. The system as a whole is then divided into a zone of smaller tubes (below 3 mm) and a zone of larger tubes extending up to the aorta. It is shown that as a system each labyrinth of tubes below the 3 mm size may be replaced by a single impedance transformation which is dominantly resistive-capacitive. In the larger tubes, the transformation of the pulse wave at different stations is considered a point of interest. Therefore hand calculated examples are worked to derive the response of a system involving some of the larger vessels to a pressure or flow pulse of the typical shape seen near the heart. The result suggests that the dicrotic wave seen in the pressure pulse of mammals is due to the hybrid viscosity-momentum nature of the longer fluid lines in relation to the gradation of unmatched terminal impedances with which they are terminated. Damping of the higher frequency components is also accounted for.
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    Bulletin of mathematical biology 30 (1968), S. 427-435 
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    Notes: Abstract Generalized equations are developed for the age structure of growing cell populations when other parameters besides chronological age are taken into account. These are summarized in a parameter which we call “chronological age”. The theory is Markovian in spirit and leads to an integro-differential equation for population density which generalizes several equations now appearing in the literature. Approximations to the fundamental equation are suggested.
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    Bulletin of mathematical biology 30 (1968), S. 415-425 
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    Notes: Abstract A similarity between the concepts of reproduction and explanation is observed which implies a similarity between the less well understood concepts of complete self-reproduction and complete self-explanation. These latter concepts are shown to be independent from ordinary logical-mathematical-biological reasoning, and a special form of complete self-reproduction is shown to be axiomatizable. Involved is the question whether there exists a function that belongs to its own domain or range. Previously, Wittgenstein has argued, on intuitive grounds, that no function can be its own argument. Similarly, Rosen has argued that a paradox is implied by the notion of a function which is a member of its own range. Our result shows that such functions indeed are independent from ordinary logical-mathematical reasoning, but that they need not imply any inconsistencies. Instead such functions can be axiomatized, and in this sense they really do exist. Finally, the introduced notion of complete self-reproduction is compared with “self-reproduction” of ordinary biological language. It is pointed out that complete self-reproduction is primarily of interest in connection with formal theories of evolution.
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    Bulletin of mathematical biology 30 (1968), S. 437-453 
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    Notes: Abstract A theoretical model of the cornea based on corneal dimensions and reported properties is presented in this paper. It is shown that because of large differences in the thicknesses of the Bowman’s and Descemet’s membranes and the stroma, and because of the reported large differences in the elastic properties of the layers, a sandwich-shell model is a good approximation for the study of corneal deformation. The theory is applicable for applanation tonometry. A set of equilibrium equations based on Reissner’s theory is given. Shell parameters which determine the behavior of shells are expressed in terms of the corneal properties and dimensions. Numerical examples which show the effects of corneal parameters on the stress resultants due to intraocular pressure are also given.
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    Bulletin of mathematical biology 30 (1968), S. 553-563 
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    Notes: Abstract A study was made of populations in stationary equilibrium that satisfy the following conditions: (1) The birth rate is very large in relation to the capacity of the habitat. (2) The part of the mortality which is independent of age is easily measured and is found to be very high. For these populations the following conclusions were drawn from the experimental observations: (1) The populations in steady state show an inversely proportional relation between the maximum average age of its components and the mortality. (2) The biomass of a population in a steady state saturating a habitat remains constant in spite of changes in the mortality. (3) The population of organisms continually growing through life, whose steady-state equilibria are reached under conditions of high mortality are composed of great numbers of individuals with a small average size. The equilibria which are reached under conditions of low mortality are characterized by a small number of individuals with large average size.
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    Bulletin of mathematical biology 30 (1968), S. 565-579 
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    Notes: Abstract A mathematical model for learning of a conditioned avoidance behavior is presented. An identification of the net excitation of a neural model (Rashevsky, N., 1960.Mathematical Biophysics. Vol. II. New York: Dover Publications, Inc.) with the instantaneous probability of response is introduced and its usefulness in discussing block-trial learning performances in the conditioned avoidance situation is outlined for normal and brain-operated animals, using experimental data collected by the author. Later, the model is applied to consecutive trial learning and connection is made with the approach of H. D. Landahl (1964. “An Avoidance Learning Situation. A Neural Net Model.”Bull. Math. Biophysics,26, 83–89; and 1965, “A Neural Net Model for Escape Learning.”Bull. Math. Biophysics,27, Special Edition, 317–328) wherein lie further data with which the model can be compared.
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    Bulletin of mathematical biology 30 (1968), S. 581-614 
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    European journal of wildlife research 11 (1965), S. 121-135 
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    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Description / Table of Contents: Summary 16 pairs of hawk out of the Northern German territory were investigated according to views of biological dietetics. It was shown that in the surroundings of Berlin the house pigeon is the prey preferred. In the Northern German inland regions Corvidae (jays, magpies, crows) as well as squirrels and rabbits are forming the basis of nutrition. The hawks of the Baltic sea coasts prefer water fowls (ducks and gulls). In the nutrition of the young thrushes, starlings, chaffinches, and other small birds, which the male hawk takes to the eyrie, play an important part. The adult hawks prefer for themselves always bigger prey. The small damage caused by hawks to shooting was in all cases balanced by the Corvidae, rabbits, and squirrels slain.
    Abstract: Resumé 16 couples d'autours pris sur la territoire de l'Allemagne du Nord furent examinés de façon bio-nutritive. Cet examen faisait voir que—aux environs de Berlin—le pigeon domestique était l'animal de proie préféré. Dans l'intérieur de l'Allemagne du Nord les corvidés (geais, pies, corneilles) ainsi que l'écureuil et le lapin constituent la base de l'alimentation. Les autours habitant la côte de la mer Baltique s'attaquent en premier lieu aux oiscaux aquatiques (canards et mouettes). Pour la nourriture des jeunes, les grives, étourneaux, pinsons et autres menus oiseaux que l'autour mâle rapporte au nid jouent un rôle important. Les vieux autours préfèrent pour leur besoin personel, une plus grande proie. Les dégâts de chasse peu importants, occasionnés par les autours examinés, furent égalisés dans tous les cas par les oiseaux corbeaux, lapins et écureuils capturés.
    Notes: Zusammenfassung 16 Habichtspaare aus dem norddeutschen Raum wurden ernährungsbiologisch untersucht. Es zeigte sich, daß in der Umgebung von Berlin die Haustaube das bevorzugte Beutetier ist. Im norddeutschen Binnenland bilden Rabenvögel (Eichelhäher, Elstern, Krähen) sowie Eichhorn und Wildkaninchen die Grundlage der Ernährung. Bei den Habichten der Ostseeküste stehen Wasservögel (Enten und Möwen) an erster Stelle. In der Ernährung der Jungen spielen Drosseln, Stare, Buchfinken und andere Kleinvögel, die vom männlichen Habicht an den Horst gebracht werden, eine wichtige Rolle. Für den Eigenbedarf der alten Habichte wird durchweg größere Beute bevorzugt. Der geringe jagdliche Schaden der untersuchten Habickte wurde in allen Fällen durch die erbeuteten Rabenvögel, Kaninchen und Eichhörnchen ausgeglichen.
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    European journal of wildlife research 11 (1965), S. 155-158 
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    European journal of wildlife research 14 (1968), S. 28-30 
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    Notes: Zusammenfassung Es wird über einen vollständigen, beiderseitigen abdominalen Kryptorchismus beim Rehbock berichtet. Der pathologisch-anatomische sowie der histologische Untersuchungsbefund der atrophierten Hoden zeigen eine fehlende Spermiogenese. Die Stummelgehörnbildung läßt Rückschlüsse auf die mangelnde Hormonproduktion der Leydigschen Zwischenzellen zu.
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    European journal of wildlife research 14 (1968), S. 30-31 
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    European journal of wildlife research 14 (1968), S. 31-34 
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