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  • Artikel  (8)
  • Metabolism
  • Springer  (8)
  • 1980-1984  (5)
  • 1965-1969  (3)
  • 1925-1929
  • 1982  (5)
  • 1969  (3)
  • 1928
  • 1926
  • Medizin  (8)
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  • Artikel  (8)
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  • Springer  (8)
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  • 1980-1984  (5)
  • 1965-1969  (3)
  • 1925-1929
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  • 1
    Digitale Medien
    Digitale Medien
    The effect of excessive acid feeding on bone (1969)
    Springer
    Calcified tissue international 4 (1969), S. 94-100 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Acid ; Base equilibrium ; Acidosis ; Bone ; Resorption ; Metabolism ; Osteoporosis
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Beschreibung / Inhaltsverzeichnis: Résumé L'administration chronique de chlorure d ammonium à des rats adultes normaux, soumis à un régime contenant un taux approprié de vitamine D, provoque une ostéoporose. Celle-ci est provoquée par une perte de substance d'os et de minéral osseux, associée à l'augmentation de la résorption osseuse.
    Kurzfassung: Zusammenfassung Chronische Verabreichung von Ammoniumchlorid an normale ausgewachsene männliche Ratten, die eine entsprechende Vitamin-D-haltige Diät erhalten, verursacht die Entwicklung einer Osteoporose. Die Osteoporose entsteht auf Grund eines Verlustes von Knochensubstanz und Knochenmineral, in Begleitung einer erhöhten Knochenresorption.
    Notizen: Abstract Excessive administration of ammonium chloride to normal adult male rats receiving a diet adequate in vitamin D caused the development of osteoporosis. The osteoporosis was due to loss of bone substance and bone mineral associated with increased bone resorption.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02279111
    Standort Signatur Erwartet Verfügbarkeit
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  • 2
    Digitale Medien
    Digitale Medien
    Serum calcium and phosphate changes in thyroidectomized dogs (1969)
    Springer
    Calcified tissue international 4 (1969), S. 188-192 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Serum ; Calcium ; Phosphate ; Calcitonin ; Thyroidectomy ; Metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Beschreibung / Inhaltsverzeichnis: Résumé Après ablation des glandes thyroïdes de chiens, sans lèser les glandes parathyroïdiennes supérieurs, les taux en calcium et phosphate sériques et la gravité spécifique sont comparées avec des valeurs d'un groupe de chiens, chez lesquels une intervention simulée est réalisée. Immédiatement après thyroïdectomie, le taux de phosphate est plus élevé que le taux de calcium. Ce taux de phosphate se maintient plus longtemps à un niveau élevé que le taux de calcium, après thyroïdectomie. Le rapport entre l'augmentation du phosphate et le taux initial de phosphate sérique chez chaque animal indique des variations normales de la calcitonine d'un animal à l'autre.
    Kurzfassung: Zusammenfassung Bei Hunden wurde die Thyreoidea entfernt, ohne die Parathyreoidea zu verletzen. Der Gehalt des Serums an Calcium und Phosphat sowie sein spezifisches Gewicht wurden mit den Werten verglichen, welche nach einer Scheinoperation bei einer Kontrollgruppe von Hunden bestimmt wurden. Unmittelbar nach der Thyreoidektomie war der Phosphatspiegel höher als jener des Calciums. Der Phosphatspiegel blieb nach der Thyreoidektomie länger hoch als der Calciumspiegel. Das Verhältnis zwischen dem Phosphatanstieg und dem Ausgangswert des Serumphosphates bei jedem Tier wies auf normale Variationen der Calcitonin-Konzentration bei verschiedenen Tieren hin.
    Notizen: Abstract The thyroid glands were removed from dogs without interfering with the superior parathyroid glands. Levels of serum calcium, phosphate, and specific gravity were measured subsequently for 24 hours, and these values were compared with values obtained from a control group of dogs in which a mock operation was done. Immediately after thyroidectomy, the level of phosphate was greater than the calcium level. The phosphate level remained high longer after thyroidectomy than did the calcium level. The relationship between the increase in phosphate level and the initial serum phosphate value in each animal indicated normal variations in calcitonin levels in different animals.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02279121
    Standort Signatur Erwartet Verfügbarkeit
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  • 3
    Digitale Medien
    Digitale Medien
    Fluoride and bone (1969)
    Springer
    Calcified tissue international 3 (1969), S. 1-16 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Fluoride ; Metabolism ; Toxicity ; Action ; Therapeutics
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02058641
    Standort Signatur Erwartet Verfügbarkeit
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  • 4
    Digitale Medien
    Digitale Medien
    Changes in plasma bone GLA protein during treatment of bone disease (1982)
    Springer
    Calcified tissue international 34 (1982), S. 121-124 
    Details
    ISSN: 1432-0827
    Schlagwort(e): Bone ; Calcium ; Metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin , Physik
    Notizen: Summary Bone Gla protein (BGP) was measured in the plasma by radioimmunoassay (RIA) during treatment of 59 patients with bone diseases including Paget's disease (N=9), primary hyperparathyroidism (N=25), chronic renal failure (N=20), and cancer involving bone (N=5). Plasma BGP was increased above normal in all patients. BGP decreased in the patients with Paget's disease following the acute and chronic administration of salmon calcitonin. Plasma BGP was higher in women then in men with primary hyperparathyroidism. Following parathyroidectomy, BGP decreased in both sexes but the decrease was significant in women only. Plasma BGP was increased in patients with renal osteodystrophy and did not change after hemodialysis. In the patients with bone cancer, plasma BGP decreased during treatment of the attendant hypercalcemia with salmon calcitonin. Although plasma BGP and serum alkaline phosphatase (AP) levels were generally correlated in these studies, there were examples of dissociation between the two. The measurement of plasma BGP appears to provide a specific index of bone metabolism that may in some circumstances be more sensitive than serum alkaline phosphatase measurement. However, further studies are necessary to establish the clinical value of plasma BGP measurement by RIA in the management of patients with bone diseases.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02411221
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
    Digitale Medien
    Digitale Medien
    Turnover with nonidentical sources of labelled and unlabelled substance (1982)
    Springer
    Annals of biomedical engineering 10 (1982), S. 161-174 
    Details
    ISSN: 1573-9686
    Schlagwort(e): Tracer kinetics ; Compartments ; Turnover ; Metabolism
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin , Technik allgemein
    Notizen: Abstract The rate of appearance or production of a metabolite in steady state in an intact animal (e.g., the number of moles per minute of glucose or lactate which are released into the blood) is measured by infusing a tracer into the system at a constant rate. Often one can regard both the unlabelled metabolite and the labelled metabolite (tracer) as entering the system in the same fluid pool, so that as equilbrium is approached, specific activity (the ratio of the concentration of labelled to unlabelled substance) becomes constant throughout the organism. The method for calculating the rate of appearance for this case is well known. When it is not possible to infuse the tracer in such a manner, gradients in specific activity must appear. This necessitates a change in the method of calculation. The rate at which the unlabelled metabolite enters the body is now given by the rate of infusion of tracer, multiplied by the ratio of the concentration of the unlabelled substance in the pool of entry of the tracer, to the concentration of the tracer in the pool of entry of the unlabelled metabolite. Violation of this rule can produce appreciable errors in the calculation of the rate of appearance. This new rule suggests a generalization of the concept of specific activity.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02367388
    Standort Signatur Erwartet Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Ultrastructure and metabolism of skeletal muscle fibres in the tench: Effects of long-term acclimation to hypoxia (1982)
    Springer
    Cell & tissue research 227 (1982), S. 179-199 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Hypoxia acclimation ; Muscle ultrastructure ; Liver ; Metabolism ; Teleosts
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Tench (Tinca tinca) were acclimated to either aerated (P O 2 17.6 KPa) or hypoxic (P O 2 1.5 KPa) water for 6 weeks. Acclimation to hypoxia resulted in a decrease in mitochondrial volume fraction in both slow (22.9 to 15.0 %) and fast glycolytic (4.5 to 1.8 %) myotomal muscles fibres (P〈0.01). Intermyofibrillar mitochondrial populations (4.4 to 1.2% slow; 0.6 to 0.04% fast fibres) were affected to a greater extent than those in the subsarcolemmal zone (18.5 to 13.8% slow; 3.9 to 1.8% fast fibres). After acclimation to hypoxia, cytochrome-oxidase activities decreased by 31 and 33 % in slow and fast fibres, respectively, but were maintained in the liver. Fibre size remained unchanged and actively differentiating fibres were observed in muscles from both groups of fish. Hypoxia resulted in a significant increase in myofibrillar volume fraction in both slow (43.1 to 56.1 %) and fast glycolytic fibres (73.1 to 82.7%) (P〈0.05). Glycogen concentrations (mg/100g tissue) for liver (6616) slow muscle (1892) and fast muscle (334) were similar for fish acclimated to aerated or hypoxic water. Acclimation to hypoxia increased carnitine palmitoyl transferase activity (μmoles substrate utilised g·dry wt-1 min-1) in slow (0.42 to 1.1), fast glycolytic muscle (〈0.01 to 0.15) and liver (1.1 to 3.7) indicating an enhanced capacity for fatty acid oxidation. Phosphofructokinase activities of fast glycolytic fibres were similar in fish acclimated to either aerated or hypoxic water, consistent with an unaltered capacity for anaerobic glycogenolysis. Hexokinase activities (μmoles substate utilised, g·dry wt-1 min-1) decreased in fast fibres (1.2 to 0.4) but were maintained in the slow muslce (2.1 to 2.5) and liver (4.5 to 4.8) of hypoxic fish. The activities of phosphofructokinase in slow muscle and phosphofructokinase, pyruvate kinase and lactate dehydrogenase in liver were two times higher in fish acclimated to hypoxia. An enhanced capacity for glycolysis in these tissues may reflect a reduced threshold for anaerobic metabolism during activity and/or an adaptation for acute exposure to anoxia in fish acclimated to hypoxia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00206340
    Standort Signatur Erwartet Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    Routine overnight starvation and immunocytochemistry of hepatocyte albumin content (1982)
    Springer
    Cell & tissue research 227 (1982), S. 423-427 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Liver (Rat) ; Albumin ; Metabolism ; Hepatocytes ; Immunocytochemistry ; Nutrition
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary The indirect immunoperoxidase method was used to identify albumin in hepatocytes of rats before and after periods of starvation. All hepatocytes in fed rats contained a relatively large amount of nascent albumin. Overnight fasting reduced the number of hepatocytes with a large amount of albumin to primarily those surrounding terminal hepatic venules. These were estimated to be about 30% of the population. The other cells had only a slight amount of albumin. After 48 h of fasting all hepatocytes contained a low level of albumin.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00210896
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
    Digitale Medien
    Digitale Medien
    Autoradiographic studies of protein and polysaccharide synthesis during vitellogenesis in Drosophila (1982)
    Springer
    Cell & tissue research 224 (1982), S. 315-333 
    Details
    ISSN: 1432-0878
    Schlagwort(e): Oogenesis ; Vitellogenesis ; Radiolabelling ; Metabolism ; Drosophila
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie , Medizin
    Notizen: Summary Quantitative light- and electron-microscopic autoradiography was used to evaluate metabolic processes that occur during late developmental stages (10–14) of oogenesis in Drosophila melanogaster. Major differences in radiolabelling patterns were found after in vivo (10–45 min) uptake of [3H]-monosaccharides and [3H]-L-lysine. Several different methods of data analysis were required to facilitate interpretation of these patterns. [3H]-L-lysine produced extensive cytoplasmic labelling at all developmental stages. In addition, about 15% of alpha yolk spheres were intensely labelled at stage 10, reflecting the incorporation of radiolabelled vitellogenins synthesized during the incubation period. Subsequent stages showed low silver grain density over alpha yolk spheres until stage 14, when a burst of [3H]-L-lysine incorporation by most alpha spheres was observed, possibly indicative of a maturation process for embryogenesis. [3H]-D-glucose and [3H]-D-galactose (10 min, in vivo) both induced intense labelling of the beta yolk spheres in a manner suggesting in situ assembly beginning at early stage 13. Inasmuch as the polysaccharide of beta yolk spheres has the properties of glycogen (e.g., rosette structure digested by α-amylase) and the radiolabelled monosaccharides were introduced intraabdominally, it is evident that transport systems as well as enzymes utilizing glucose and galactose for glycogenesis must be readily available. It is notable that wide-spread labelling of egg chambers was elicited by [3H]-D-glucose and [3H]-D-galactose (e.g., nurse cells, follicle cells, chorion, vitelline membrane), but the labelling induced by [3H]-N-acetylmannosamine was restricted mainly to the endochorion. A possible role of microtubules in distribution and assembly of yolk spheres was inferred when colchicine, admixed to the culture medium (2–5 ppm), produced abnormal distribution and diminution in number of both alpha and beta yolk spheres. In addition to revealing previously unknown metabolic events of vitellogenesis, the results provide additional criteria for stage characterization as well as a means to specifically label certain macromolecules for purposes of isolation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00216876
    Standort Signatur Erwartet Verfügbarkeit
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