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1

Digitale Medien

Biosynthetic labeling of RNA with uracil phosphoribosyltransferase allows cell-specific microarray analysis of mRNA synthesis and decay (2005)

Cleary, Michael D ; Meiering, Christopher D ; Jan, Eric ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 232-237

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Standard microarrays measure mRNA abundance, not mRNA synthesis, and therefore cannot identify the mechanisms that regulate gene expression. We have developed a method to overcome this limitation by using the salvage enzyme uracil phosphoribosyltransferase (UPRT) from the protozoan Toxoplasma ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1061

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2

Digitale Medien

Complete genome sequence of the acetic acid bacterium Gluconobacter oxydans (2005)

Prust, Christina ; Hoffmeister, Marc ; Liesegang, Heiko ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 195-200

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Gluconobacter oxydans is unsurpassed by other organisms in its ability to incompletely oxidize a great variety of carbohydrates, alcohols and related compounds. Furthermore, the organism is used for several biotechnological processes, such as vitamin C production. To further our understanding of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1062

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3

Digitale Medien

Detection of parallel functional modules by comparative analysis of genome sequences (2005)

Li, Huiying ; Pellegrini, Matteo ; Eisenberg, David

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 253-260

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Parallel functional modules are separate sets of proteins in an organism that catalyze the same or similar biochemical reactions but act on different substrates or use different cofactors. They originate by gene duplication during evolution. Parallel functional modules provide versatility and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1065

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4

Digitale Medien

Minimum information requested in the annotation of biochemical models (MIRIAM) (2005)

Finney, Andrew ; Hucka, Michael ; Bhalla, Upinder S ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1509-1515

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Most of the published quantitative models in biology are lost for the community because they are either not made available or they are insufficiently characterized to allow them to be reused. The lack of a standard description format, lack of stringent reviewing and authors' carelessness are the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1156

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5

Digitale Medien

The complete genome sequence of the meat-borne lactic acid bacterium Lactobacillus sakei 23K (2005)

Chaillou, Stéphane ; Champomier-Vergès, Marie-Christine ; Cornet, Monique ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1527-1533

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Lactobacillus sakei is a psychrotrophic lactic acid bacterium found naturally on fresh meat and fish. This microorganism is widely used in the manufacture of fermented meats and has biotechnological potential in biopreservation and food safety. We have explored the 1,884,661-base-pair (bp) circular ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1160

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6

Digitale Medien

Efficient differentiation of human embryonic stem cells to definitive endoderm (2005)

D'Amour, Kevin A ; Agulnick, Alan D ; Eliazer, Susan ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1534-1541

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive endoderm, such as the pancreas. We have ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1163

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7

Digitale Medien

Combined static and dynamic analysis for determining the quality of time-series expression profiles (2005)

Simon, Itamar ; Siegfried, Zahava ; Ernst, Jason ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1503-1508

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Expression profiling of time-series experiments is widely used to study biological systems. However, determining the quality of the resulting profiles remains a fundamental problem. Because of inadequate sampling rates, the effect of arrest-and-release methods and loss of synchronization, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1164

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8

Digitale Medien

The problem with potency (2005)

Scott, Christopher Thomas

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1037-1039

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] As the $30 billion monoclonal antibody (mAb) market moves from murine-based to chimeric and fully human products, it grows at a compounded clip of nearly 20% per year (see ). This spectacular growth—Synagis (pavilivizumb; MedImmune, Gaithersburg, Maryland), Herceptin (trastuzumab; ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1037

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9

Digitale Medien

Problems with metagenomic screening (2005)

de Lorenzo, Victor

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1045-1045

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: The paper by Kazuya Watanabe and colleagues published in the January issue (Nat. Biotechnol. 23, 88–93, 2005) is framed both in the paper itself and in the accompanying News & Views by Jo Handelsman (Nat. Biotechnol. 23, 38–39, 2005) as an astute, general genetic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1045a

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10

Digitale Medien

Reply to "Problems with metagenomic screening" (2005)

Watanabe, Kazuya ; Uchiyama, Taku

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1045-1046

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Watanabe and colleagues respond: de Lorenzo outlines some possible limitations of the substrate-induced gene expression screening (SIGEX) method. Although we discussed many of the points in his letter in our paper, it is worth reiterating them to emphasize the challenges faced in designing a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1045b

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11

Digitale Medien

Open source and biotech (2005)

Bains, William

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1046-1046

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: Your editorial in the June issue (Nat. Biotechnol. 23, 633, 2005) on the biotech open source movement skirted round one critical difference between biotech and the software industry whose 'open source' movement Richard Jefferson seeks to emulate. Writing software is cheap and can be ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1046

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12

Digitale Medien

Synthesis & sequencing (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1019-1019

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nanotech-based sequencing Roche and 454 Life Sciences, a subsidiary of CuraGen, offer a nanotechnology-based genome sequencing system that allows a single instrument to produce over 20 million nucleotide bases per 4-hour run, totaling more than 100 times the capacity of instruments using current ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-1019a

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13

Digitale Medien

Illuminating BiDil (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 903-903

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] BiDil is a recently approved therapy indicated for congestive heart failure patients already taking standard treatments. It is not a new drug. It is a combination of two existing drugs—isosorbide dinitrate and hydralazine—already marketed seperately as generics. What is new about BiDil ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-903

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14

Digitale Medien

Japan-China merger puts growth in East Asia first (2005)

Sipp, Doug

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 907-907

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The Tokyo-based pharmaceutical development firm GNI announced its merger with Shanghai Genomics on June 20, marking the first such partnership between a Japanese and a Chinese biotech in over a decade. The newly formed venture has a research staff of more than 80 in Japan, China and England, and a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-907

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15

Digitale Medien

Profile: William Haseltine (2005)

Herrera, Stephan

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 913-913

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] During the 13 years that he was CEO of Human Genome Sciences (HGS), William Haseltine rarely traveled for pleasure. He was even less mobile before his tenure at the Rockville, Maryland–based genomics firm that he founded in 1992; as a cancer and AIDS researcher at the Dana Farber Cancer ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-913

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16

Digitale Medien

Enthusiasm cools in Q2 (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 914-914

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Although private financing and overall funding remain relatively stable, investor interest in biotech is a shadow of a year ago, when the initial public offering (IPO) market had just come off the best two quarters of this window. The BioCentury 100 Index has fallen by a little more than 10%, and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-914

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17

Digitale Medien

si RNA becomes smart and intelligent (2005)

Miyagishi, Makoto ; Taira, Kazunari

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 946-947

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In just a few years, small interfering RNA (siRNA) has emerged as a powerful technology to specifically knockdown genes in mammalian cells both for functional analysis and for therapeutic purposes. The success of this approach, also called RNA interference (RNAi), hinges on the affinity of an siRNA ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0805-946

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18

Digitale Medien

Probabilistic model of the human protein-protein interaction network (2005)

Rhodes, Daniel R ; Tomlins, Scott A ; Varambally, Sooryanarayana ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 951-959

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A catalog of all human protein-protein interactions would provide scientists with a framework to study protein deregulation in complex diseases such as cancer. Here we demonstrate that a probabilistic analysis integrating model organism interactome data, protein domain data, genome-wide gene ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1103

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19

Digitale Medien

Pessimistic response to FDA leadership change (2005)

Kling, Jim

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1325-1325

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In September, Lester Crawford resigned as commissioner of the US Food and Drug Administration (FDA), leaving a leadership vacuum that was quickly filled by President Bush's appointment of Andrew von Eschenbach, formerly the director of the National Cancer Institute (NCI), as acting commissioner. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1325

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20

Digitale Medien

Sandoz sues FDA over delay in first biogeneric approval (2005)

Fox, Jeffrey L.

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1327-1328

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Officials at Sandoz, the generic branch of Novartis of Basel, filed a rare type of lawsuit with the US District Court on September 13. The company wants the court to force the US Food and Drug Administration (FDA) to rule on—preferably, approve—Omnitrope, its follow-on version of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1327

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21

Digitale Medien

News In Brief (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1329-1330

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Cabilly patent invalidated Genentech's stronghold on monoclonal antibody production techniques may slip if a recent US Patent and Trademark Office's (USPTO) initial ruling is upheld. In late September, the USPTO rejected the company's ubiquitous Cabilly 2 patent on the grounds that it extends the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1329

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22

Digitale Medien

Biotech marks time in Q3 (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1332-1332

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In a risk-averse market, biotech stock market indices showed sluggish growth, being outperformed by broader market indicators. Venture capital funding remained relatively stable but public biotechs were able to take advantage of debt, private investment in public equitities (PIPEs) and follow-on ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1332

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23

Digitale Medien

Profile: Eduardo Kac (2005)

Herrera, Stephan

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1331-1331

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Is Chicago artist-writer-philosopher Eduardo Kac ahead of his time or just nuts? In the foreword of his new book, Art Institute of Chicago art historian James Elkins makes the case for the former. Elkins acknowledges, however, that not everybody agrees on this point and cites the negative critiques ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1331

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24

Digitale Medien

The search for a sequencing thoroughbred (2005)

Kling, Jim

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1333-1335

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The Human Genome Project cost nearly $3 billion, and no one would quibble with the price tag. The scientific benefit is incalculable. But translating the potential of genomics into tangible benefits for basic and biomedical research, not to mention personalized medicine, will require vast ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1333

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25

Digitale Medien

BiDil's impact (2005)

Puckrein, Gary ; Yancy, Clyde W.

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1343-1343

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: We were greatly disturbed to read your editorial in the August issue (Nat. Biotechnol. 23, 903, 2005) which made disparaging comments about BiDil, a new heart failure medication for blacks that has been shown clearly to be safe and effective. Despite misleading claims in your ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1343a

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26

Digitale Medien

Response to BiDil's impact (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1343-1344

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nature Biotechnology responds to BiDil's impact: In citing their three 'crucial' facts, Puckrein and Yang sidestep the main point of our editorial: BiDil is a poor example of targeted medicine. As far as we know, skin pigmentation has not yet been genetically linked to (less still shown to be an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1343b

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27

Digitale Medien

Bringing safe and effective cell therapies to the bedside (2005)

Preti, Robert A

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 801-804

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] With relatively little fanfare, the current Good Tissue Practices (cGTP) Final Rule finally came into force in the United States in May. Under its legal authority, the US Food and Drug Administration (FDA) now inspects entities involved in the manufacture of human cells, tissues, and cellular and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0705-801

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28

Digitale Medien

Response to 'On-the-fly' or 'generate-first' modeling? (2005)

Lok, Larry ; Brent, Roger

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1345-1345

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Lok and Brent respond: Our simulation program, Moleculizer, calculates cellular reaction networks by allowing protein complexes to form in silico. From the correspondence of Hlavacek and colleagues, we take two main points. They argue that there are advantages to generating reaction networks ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1345

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A farewell to bacterial ARMs? (2005)

Rea, Philip A

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1085-1087

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In a stroke of serendipity, researchers investigating plant responses to the explosive TNT have stumbled upon a transporter gene that may obviate the need for bacterial selectable markers in the generation of transgenic plants. As described in this issue, Mentewab and Stewart were studying the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1085

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Digitale Medien

Response to Molecule–kinase interaction map (2005)

Fabian, Miles A. ; Biggs, William H. ; Treiber, Daniel K. ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1346-1348

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Fabian et al. respond: Buolamwini and Kamath suggest that the data presented in our manuscript lack statistical validation and are not sufficiently quantitative to justify some of our conclusions. In particular, they state that the validation of our technology, which included a detailed comparison ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1346b

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Digitale Medien

Plant transgenic science knowledge (2005)

Vain, Philippe

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1348-1349

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Notizen: [Auszug] To the editor: Monitoring the evolution of plant transgenic science is hampered by the difficulty of obtaining accurate bibliometric information compared with equivalent animal and microbial research. This is mostly due to the imprecision of the term 'transformation,' which is generally used to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1348

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Digitale Medien

Why tissue engineering needs process engineering (2005)

Archer, Richard ; Williams, David J

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1353-1355

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Tissue engineering is having difficulty transitioning from a development-stage industry to one with a successful product portfolio. Currently, many of the key international tissue-engineering centers focus almost exclusively on the biology of tissue culture to the detriment of manufacturing and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1353

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Digitale Medien

Bright new world (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1357-1357

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Notizen: [Auszug] In Liberation Biology, Ronald Bailey grapples with many of the key ethical issues raised by our advances in biotech. He seeks to counterbalance the bleak vision of the future, akin to Huxley's Brave New World, predicted by Leon Kass, Francis Fukuyama and other 'bioconservatives.' Bailey's own ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1357

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Digitale Medien

The number on biotech indexes (2005)

Jacobs, Tom

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1356-1356

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Those of us who invest in stocks can repeat the major indexes of market performance in our sleep because they are ubiquitous in the financial media. The S&P, FTSE, CAC, DAX and Nikkei are acronyms known worldwide for their alleged measure of the US, UK, French, German and Japanese stock ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1356

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The business of making vaccines (2005)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1359-1366

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The landscape in vaccine manufacturing has changed radically over the past 30 years. In 1967, over a dozen licensed vaccine manufacturers operated in the United States alone. This number has since collapsed through mergers and exits to barely a handful. Low profit margins, the introduction in 1980 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1359

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Digitale Medien

Reexamining the research exemption (2005)

Flores, Mauricio A ; Campbell, Cathryn

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 659-661

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The extent to which biomedical research is subject to the patent laws continues to trouble scientists and decision makers in the pharmaceutical and biotech industries. Many hope that the Supreme Court will clarify this issue when it decides this summer Integra LifeSciences v. Merck KGaA, a case ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0605-659

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Digitale Medien

Biofilms strike back (2005)

O'Toole, George A ; Stewart, Philip S

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1378-1379

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Excessive use of antibiotics has increased resistance of many microbes to these drugs. In a recent issue of Nature, Hoffman et al. show that too little antibiotic can also be detrimental. They demonstrate that subinhibitory levels of the aminoglycoside-class antibiotic tobramycin increase biofilm ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1378

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Digitale Medien

A classic assembly of nanobiomaterials (2005)

Mershin, Andreas ; Cook, Brian ; Kaiser, Liselotte ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1379-1380

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In antiquity, Crete was known as the crossroads of the Mediterranean. Minoan culture was enriched and invigorated by its diverse mix of cultures and thriving commerce with Africa, Europe and Asia. This ancient crossroads was somewhat fitting therefore as a backdrop for a conference that sought to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1379

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Digitale Medien

'Magic' scissors for genome surgery (2005)

Kandavelou, Karthikeyan ; Mani, Mala ; Durai, Sundar ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 686-687

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A robust and reproducible means of specifically correcting 'faulty' bases in genes has been a longtime goal in genetic medicine. In a recent issue of Nature, Urnov et al. use four-finger zinc finger chimeric endonucleases (ZFNs) to achieve highly efficient and permanent alteration of the gene ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0605-686

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Digitale Medien

Gene targeting using zinc finger nucleases (2005)

Carroll, Dana ; Porteus, Matthew H

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 967-973

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The ability to achieve site-specific manipulation of the mammalian genome has widespread implications for basic and applied research. Gene targeting is a process in which a DNA molecule introduced into a cell replaces the corresponding chromosomal segment by homologous recombination, and thus ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1125

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Politics torpedo biotech as EU priority (2005)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 766-767

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Ambitious plans by the European Commission (EC) to double research spending during 2007–2013 were quietly shelved during the run-up to a political summit of EU heads of state on June 15–16. The present budgetary impasse, combined with an ongoing paucity of funding, has cast doubts over ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0705-766

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Digitale Medien

Activation of the mammalian immune system by siRNAs (2005)

Marques, Joao T ; Williams, Bryan R G

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1399-1405

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Inhibition of gene expression through RNA interference (RNAi) is emerging as a powerful experimental tool for gene function and target validation studies. The potential uses of this technology seem unlimited, extending to the prevention and therapy of human diseases. However, recent work ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1161

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Digitale Medien

Acquisition signals shift from US market (2005)

Mitchell, Peter

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 635-635

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The US biotech market may be losing its former center-stage position for European companies, judging by the $1.6 billion cash acquisition of Transkaryotic Therapies, of Wayne, Pennsylvania, by the mid-sized European pharmaceuticals firm Shire of Basingstoke, UK. An increasingly difficult ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0605-635

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Digitale Medien

Multi-kinase inhibitors create buzz at ASCO (2005)

Branca, Malorye A.

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 639-639

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Some of the most anticipated results at this year's American Society of Clinical Oncology (ASCO) meeting were from phase 3 trials of two targeted therapies with multiple mechanisms of action—also known as multi-kinase inhibitors. These therapies are rapidly gaining ground in less common ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0605-639

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Digitale Medien

Research Highlights (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 689-689

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Cells strike a pose Weiss and colleagues have designed an artificial cellular communications network in which signaling among cells leads to the formation of various supracellular patterns. Their system includes Escherichia coli 'sender' cells genetically engineered to express the LuxI enzyme, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0605-689

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Digitale Medien

Making it in the biotech business (2005)

Gewin, Virginia

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 759-760

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Biotech is big business these days, and record numbers of PhDs are trading the ivory tower for industry. The 1,500 biotech companies in the United States alone have combined revenues exceeding $40 billion, according to the Biotechnology Industry Organization—and they need skilled ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0605-759

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Digitale Medien

Rapid generation of specific antibodies by enhanced homologous recombination (2005)

Seo, Hidetaka ; Masuoka, Mieko ; Murofushi, Hiromu ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 731-735

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In the chicken immune system, gene conversion, a type of homologous recombination, primarily contributes to diversification of the immunoglobulin gene. Here, we report on the rapid generation of specific monoclonal antibodies using the chicken DT40 B-cell line undergoing gene conversion. We ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1092

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Digitale Medien

Functional genome annotation through phylogenomic mapping (2005)

Srinivasan, Balaji S ; Caberoy, Nora B ; Suen, Garret ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 691-698

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Accurate determination of functional interactions among proteins at the genome level remains a challenge for genomic research. Here we introduce a genome-scale approach to functional protein annotation—phylogenomic mapping—that requires only sequence data, can be applied equally well to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1098

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Characterization and culture of human embryonic stem cells (2005)

Hoffman, Lisa M ; Carpenter, Melissa K

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 699-708

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Human embryonic stem cells have been defined as self-renewing cells that can give rise to many types of cells of the body. How and whether these cells can be manipulated to replace cells in diseased tissues, used to screen drugs and toxins, or studied to better understand normal development, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1102

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Earlier stage biotechs attract partners (2005)

Ratner, Mark

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 509-509

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Even as the environment for going public remains hostile to most biotech companies and their investors, some are discovering that favorable financing alternatives still exist. A spate of recent acquisitions and a continuation of early-stage deal making signify that there are still appealing ways ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0505-509

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Digitale Medien

US court case to define EST patentability (2005)

Lawrence, Stacy

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 513-513

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] On May 3, the first case appealed to the US Court of Appeals for the Federal Circuit concerning the patentability of expressed sequence tags (ESTs) is due to start, following a dispute between St. Louis, Missouri-based Monsanto and the US Patent and Trademark Office (USPTO). The case is likely to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0505-513

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Digitale Medien

Tomato transgene structure and silencing (2005)

Sanders, Rick A ; Hiatt, William

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 287-289

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: In last year's March issue (Nat. Biotechnol. 22, 267–268, 2004), Frank Rainer Schmidt provided an example of past research relevant to the current topic of RNA interference (RNAi). As a follow-up, we would like to briefly review previous work at Calgene (Davis, CA, USA; now ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0305-287b

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A very firm handshake: biotech's growing negotiating power (2005)

Thiel, Karl A

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1221-1226

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Even casual observers of the biopharmaceutical industry are aware of a mutually beneficial relationship among small, discovery-oriented biotech companies and major drug companies. While one group acts as an engine of innovation, the other brings the financing, development expertise and regulatory ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1005-1221

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Evolutionary optimization of fluorescent proteins for intracellular FRET (2005)

Nguyen, Annalee W ; Daugherty, Patrick S

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 355-360

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Fluorescent proteins that exhibit Förster resonance energy transfer (FRET) have made a strong impact as they enable measurement of molecular-scale distances through changes in fluorescence. FRET-based approaches have enabled otherwise intractable measurements of molecular concentrations, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1066

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Directed evolution of human T-cell receptors with picomolar affinities by phage display (2005)

Li, Yi ; Moysey, Ruth ; Molloy, Peter E ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 349-354

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Peptides derived from almost all proteins, including disease-associated proteins, can be presented on the cell surface as peptide–human leukocyte antigen (pHLA) complexes. T cells specifically recognize pHLA with their clonally rearranged T-cell receptors (TCRs), whose natural affinities are ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1070

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Out in the open (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 153-153

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Until recently, biotech and pharmaceutical companies have had little reason to heed calls for greater transparency in the disclosure data from their clinical trials. That all changed last year when New York State attorney general Eliot Spitzer filed a high-profile lawsuit against GlaxoSmithKline ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-153

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Profile: Margaret Atwood (2005)

Louët, Sabine

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 163-163

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] “It is not biotech that's dangerous,” claims Margaret Atwood, her sparkly blue eyes betraying the intensity of her conviction. “It is people's fears and desires.” Her latest book, Oryx and Crake, paints a grim picture of the future in which a genetically engineered virus has ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-163

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A banner biotech year in 2004 (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 164-164

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Last year's big surprise was that venture capital investment in biotech was greater than in 2000, up to $5.3 billion. Initial public offerings (IPOs) didn't fair nearly so well, but still provided the second largest amount (∼$2.5 billion) raised for biotech in more than a decade. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-164

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Struggling to see the forest through the trees (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 165-167

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A new sort of anti-GMO protest broke out last December in Argentina at the tenth anniversary United Nations (UN) conference on climate change. Protestors were not grousing about food this time, but about genetically modified (GM) trees, which, under the Kyoto Protocol set to go into effect this ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-165

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Corrigendum: Overexpression of an Arabidopsis thaliana ABC transporter confers kanamycin resistance to transgenic plants (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1315-1315

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nat. Biotechnol. 23, 1177–1180 (2005) On p. 1180, line 4, the reverse primer to amplify the gene encoding Atwbc19 was given as (5′-TGTCCCCGTTTTTATCCAAG-3′). The reverse primer used was 5′-GTCAGCGAGCTCTCACGTCCTCTTATTCCTGC-3′, which contains a SacI ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1005-1315b

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Emergent behavior of growing knowledge about molecular interactions (2005)

Cokol, Murat ; Iossifov, Ivan ; Weinreb, Chani ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1243-1247

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In the time of Isaac Newton (1643–1727), a prominent scientist could follow advances in multiple fields of knowledge—as far apart from each other as mathematics, astronomy, physics, history and theology. It took a talent of Newton's caliber, of course, to contribute to several of them ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1005-1243

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Imaging & microscopy (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1316-1316

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Imaging family Olympus's new cell* family is a range of imaging systems and software tools providing simple image acquisition and documentation to complete solutions for live cell imaging. The high-powered and mutually compatable imaging products combine excellent performance with ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1005-1316a

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Energy well spent on a prokaryotic genome (2005)

McNeil, Brian ; Harvey, Linda

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 186-187

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Bacteria of the genus Gluconobacter exhibit so-called oxidative fermentation, or incomplete oxidation, a highly unusual metabolic feature that has been exploited industrially for decades in the production of vitamin C (ascorbic acid), gluconic acid and dihydroxyacetone. In this issue, Prust et al. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-186

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Material transfer agreements: open science vs. proprietary claims (2005)

Rodriguez, Victor

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 489-491

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Although the development of pharmaceutical and biotechnological end products has been traditionally based on patents, biomedical research in academia comes from the very different tradition of open science; that is, relatively unrestricted access to fundamental knowledge developed by previous ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0405-489

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Engineering novel binding proteins from nonimmunoglobulin domains (2005)

Binz, H Kaspar ; Amstutz, Patrick ; Plückthun, Andreas

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1257-1268

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Not all adaptive immune systems use the immunoglobulin fold as the basis for specific recognition molecules: sea lampreys, for example, have evolved an adaptive immune system that is based on leucine-rich repeat proteins. Additionally, many other proteins, not necessarily involved in adaptive ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1127

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Discovery of regulatory elements in vertebrates through comparative genomics (2005)

Prakash, Amol ; Tompa, Martin

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1249-1256

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] We have analyzed issues of reliability in studies in which comparative genomic approaches have been applied to the discovery of regulatory elements at a genome-wide level in vertebrates. We point out some potential problems with such studies, including difficulties in accurately identifying ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1140

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Cost-effectiveness data on biologics needed (2005)

Sheridan, Cormac ; Katsnelson, Alla

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 272-273

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A new report, BioImpact, backed by European bioindustry lobbies, sets out the socioeconomic benefits of biotech-based therapies in ten disease areas but fails to include enough economic information to back its case. This reflects a widespread dearth of data that formally captures the cost ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0305-272

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Adding diversity to plant transformation (2005)

Chilton, Mary-Dell

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 309-310

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The production of genetically modified crops that could alleviate hunger and malnutrition in developing countries may be impeded by patents on the DNA components or on the techniques for introducing DNA into the plant genome and regenerating plants. Currently, the most widely used method of gene ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0305-309

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Erratum: International patent law—boon or bane of biotech? (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 366-366

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Nat. Biotechnol. 23, 13–15 (2005) On page 13, column 3, paragraph 4, line 16, The following, “the country's pharmaceutical exports were worth around $1.27 billion in 2004 with generics accounting for 6%” should have read “the country's total pharmaceutical output was ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0305-366a

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Patents (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 369-369

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Recent patent applications in proteomics Table ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0305-369

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China steps towards international M&A (2005)

Jia, Hepeng ; Louët, Sabine

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 159-159

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Invitrogen's acquisition of Chinese competitor BioAsia is the first major acquisition by a foreign company in the life science sector. The move has been made possible by recent changes in the Chinese legal framework surrounding mergers and acquisitions (M&A) by foreign companies in China. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-159

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Cat and mouse in regulating genetic 'enhancement' (2005)

Miller, Henry

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 171-172

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Humans seem innately to wish to transcend their physical and mental limitations. Consider, for example, the eternal quest for a Fountain of Youth that will confer immortality. More modest, real-world instrumentalities today include anabolic steroids, growth hormones, erythropoietin and blood ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-171

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Chasing biotech, state by state—winners and losers (2005)

Wilan, Ken Howard

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 175-179

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Although capital markets for financing biotech companies typically go up and down like a roller coaster, the number of initiatives launched by individual states to attract biotechnology to its borders has steadily climbed over the past few years. “States are always looking for money, now more ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0205-175

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Haplotyping in biomedicine—practical challenges (2005)

Nelson, Matthew R ; Cantor, Charles R

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 21-22

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Human genetics studies of complex traits have been facilitated by the completion of the human genome reference sequence, the ongoing identification of a dense set of human single nucleotide polymorphisms (SNPs) and the increasing understanding of how those variations are organized within major ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0105-21

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Functional annotation and network reconstruction through cross-platform integration of microarray data (2005)

Kao, Ming-Chih J ; Huang, Haiyan ; Wong, Angela ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 238-243

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The rapid accumulation of microarray data translates into a need for methods to effectively integrate data generated with different platforms. Here we introduce an approach, 2nd-order expression analysis, that addresses this challenge by first extracting expression patterns as meta-information from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1058

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Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells (2005)

Yasunaga, Masahiro ; Tada, Shinsuke ; Torikai-Nishikawa, Satomi ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1542-1550

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Preparation of specific lineages at high purities from embryonic stem (ES) cells requires both selective culture conditions and markers to guide and monitor the differentiation. In this study, we distinguished definitive and visceral endoderm by using a mouse ES cell line that bears the gfp and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1167

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Multivalent avimer proteins evolved by exon shuffling of a family of human receptor domains (2005)

Lu, Qiang ; Bakker, Alice ; To, Wayne ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1556-1561

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] We have developed a class of binding proteins, called avimers, to overcome the limitations of antibodies and other immunoglobulin-based therapeutic proteins. Avimers are evolved from a large family of human extracellular receptor domains by in vitro exon shuffling and phage display, generating ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1166

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Designing dendrimers for biological applications (2005)

Lee, Cameron C ; MacKay, John A ; Fréchet, Jean M J ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1517-1526

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Dendrimers are branched, synthetic polymers with layered architectures that show promise in several biomedical applications. By regulating dendrimer synthesis, it is possible to precisely manipulate both their molecular weight and chemical composition, thereby allowing predictable tuning of their ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1171

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Exiting this year and into the next (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1451-1451

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] There once was a time when the initial public offering (IPO) was without rival in the hearts and minds of biotech investors and entrepreneurs. The thought of a champagne cork-popping event like Genentech's fabulously successful IPO in 1980, which saw shares of the S. San Francisco firm leap from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1451

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Cord blood cell therapy trial suspended (2005)

Sheridan, Cormac

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1455-1456

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Among the most advanced cell therapies in clinical development, umbilical cord blood stem cell therapies used in the treatment of blood cancers are forging ahead, but it's an uphill struggle. The recent suspension of a phase 1/2 trial of a non-matched (allogeneic) cord blood therapy by Viacell ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1455

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Europe caught in innovation quagmire (2005)

Mitchell, Peter

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1029-1029

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Europe has a new plan to counter the worsening competitive position of its biopharmaceutical enterprises. But the scheme looks more tailored to meet the political aspirations of Brussels bureaucrats than to help the industry. The policy is nominally based on a report submitted by Boston-based ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1029

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Cautious industry welcome for US flu vaccine plan (2005)

Kling, Jim

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1457-1458

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The US government's recent raft of preemptive measures in favor of flu vaccine R&D and stockpiling in the wake of the October announcement of the creation of a new R&D funding agency to support biodefense research, funded by Project BioShield, may seem like a new window of opportunity for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1457

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Could bank loans solve Europe's biotech financing slump? (2005)

Mitchell, Peter

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1459-1460

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The giant European Investment Bank (EIB), based in Luxembourg, is looking to loan tens of millions of euros to biotech firms in late-stage product development. The move is aimed at boosting Europe's weak financing record, but experts are pessimistic about its prospects. The EIB initiative comes in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1459

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Profile: Dmitry Morosov (2005)

Louët, Sabine

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1465-1465

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Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Biotech venture creation in Russia can sometimes seem like roulette. Traditional models don't apply. Entrepreneurs must battle endemic bureaucracy, cronyism and corruption. And they must overcome a hostile business environment where government incentives are scarce, intellectual property (IP) ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1465

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Biotech drug market steadily expands (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1466-1466

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Unlike last year's billion dollar approvals, Avastin (bevacizumab) and Erbitux (cetuximab), no biotech blockbusters were launched in 2005 and none appear to be on the horizon. Almost half of the biologics license applications pending at the US Food and Drug Administration (FDA) are for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1466

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Digitale Medien

News In Brief (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1463-1464

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Personalized reimbursement Revenue for pharmacogenomic testing is expected to grow ∼25% a year from 2004 to 2011, according to the report “US Genetic Diagnostics Market” released in October by consultancy Frost and Sullivan of San Antonio, Texas. Current reimbursement policies, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1463

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Digitale Medien

Stem cell therapy or snake oil? (2005)

Baker, Monya

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1467-1469

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] This October, the US Food and Drug Administration (FDA) gave the green light to the Palo Alto, California-based company, Stem Cells, to inject fetal neural stem cells into the brains of children suffering from Battan disease, a devastating neurodegenerative disorder. Although this is an important ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1467

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Digitale Medien

Bacterial lessons in sausage making (2005)

Eijsink, Vincent G H ; Axelsson, Lars

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1494-1495

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Lactic acid bacteria have long been associated with the fermentation, acidification and preservation of food. People consume large amounts of these bacteria every day in products such as yogurt, cheese and fermented meats. In this issue, Chaillou et al. report the genome sequence of a highly ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1494

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Digitale Medien

Embryonic stem cells without embryos? (2005)

Grompe, Markus

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1496-1497

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Against the backdrop of fierce debates over the ethics of research on human embryonic stem (ES) cells, the President's Council on Bioethics in 2004 proposed four ways of generating human ES cells without embryo destruction (http://www.bioethics.gov/reports/white_paper/). Although these proposals ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1496

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Digitale Medien

Research Highlights (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1498-1498

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] A-maize-ing agronomic loci? The striking differences between ears of contemporary maize (right), its wild ancestor teosinte (left) and their hybrid (center) illustrate but one aspect of the extraordinary transformation of maize from its humble progenitor to the world's highest- yielding grain ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1498

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Digitale Medien

Managing your compensation expectations in today's environment: a third look (2005)

Radford, John

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1569-1570

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Three years ago, I noted that in terms of compensation, the biotech industry was a buyer's market. Eighteen months later, I suggested the industry was in a transition period heading towards a seller's market. Now, I can clearly conclude that we have moved into a seller's market: US biotech ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1569

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Digitale Medien

Expression systems (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1568-1568

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] MicroRNA assays TaqMan microRNA assays, from Applied Biosystems, are predesigned and validated probe and primer sets in a flexible format for the detection and quantification of mature human microRNA (miRNA) expression levels. The assays accommodate both large initial screening panels (many miRNAs ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1568

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Digitale Medien

How does gene expression clustering work? (2005)

D'haeseleer, Patrik

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1499-1501

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Our ability to gather genome-wide expression data has far outstripped the ability of our puny human brains to process the raw data. We can distill the data down to a more comprehensible level by subdividing the genes into a smaller number of categories and then analyzing those. This is where ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1205-1499

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China beckons to clinical trial sponsors (2005)

Jia, Hepeng

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 768-768

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The clinical trials market is opening up in China. The most recent evidence has been provided by the Danish Centre for Clinical and Basic Research (CCBR), which announced its intention to establish clinical research facilities in Beijing, independent of the state authorities. Low cost and ease of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0705-768

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Digitale Medien

State of biotech sector—2004 (2005)

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 774-774

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] In its latest annual review of the biotech industry, business consulting firm Ernst & Young finds a sector in flux (for 2003 stats see Nat. Biotechnol. 22, 789, 2004). Profitability still looks distant; although revenues for public companies were up by 17%, so were net losses. Employment was up ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0705-774

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Digitale Medien

Regulatory regimes for transgenic crops (2005)

Wilson, Allison ; Latham, Jonathan ; Steinbrecher, Ricarda

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 785-785

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: In presenting their justifications for reducing the regulatory burden on transgenic food crops (Nat. Biotechnol. 23, 439–444, 2005), we feel that Strauss and colleagues significantly misrepresent the implications and rationale of our report Genome Scrambling-Myth or Reality? ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0705-785a

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Digitale Medien

Guidelines for human embryonic stem cell research (2005)

Moreno, Jonathan D ; Hynes, Richard O

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 793-794

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] The limited federal role in funding and monitoring research involving human embryonic stem (hES) cells has raised concerns among the scientific community that the field is progressing without adequate guidance. In response, the US National Academies set up a committee, which we cochaired, to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0705-793

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Digitale Medien

'On-the-fly' or 'generate-first' modeling? (2005)

Blinov, Michael L. ; Faeder, James R. ; Yang, Jin ; [weitere]

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1344-1345

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: In a paper in the January issue (Nat. Biotechnol. 23, 131–136, 2005), Lok and Brent report methods and software, called Moleculizer, for automatically generating computational models of biochemical systems. Such rule-based modeling tools are needed to study systems marked by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1344

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Digitale Medien

The patentability of antibodies in the United States (2005)

Lu, Deborah L ; Collison, Angela M ; Kowalski, Thomas J

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1079-1080

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] Two recent court cases, Noelle v. Lederman and SmithKline Beecham v. Apotex, shed light on the patentability of antibodies. The subtleties surrounding application of US patent statutes 35 USC §§ 102 (novelty and loss of right to patent), 103 (nonobvious subject matter) and 112 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt0905-1079

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Digitale Medien

Molecule–kinase interaction map (2005)

Buolamwini, John K. ; Kamath, Shantaram

[s.l.] : Nature Publishing Group

Nature biotechnology 23 (2005), S. 1346-1346

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ISSN: 1546-1696

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung

Notizen: [Auszug] To the editor: We read with interest the article by Fabian et al. in the March 2005 issue (Nat. Biotechnol. 23, 329−336, 2005) entitled “A small molecule–kinase interaction map for clinical kinase inhibitors.” Although the study is an elegant attempt at rapidly determining ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nbt1105-1346a

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