ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Digitale Medien

Androgen receptor and familial prostate cancer (1995)

Sun, Sophie ; Narod, Steven A. ; Aprikian, Arman ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 848-849

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor —From a population-based study of 55,000 American males, Monroe et al. estimate the relative risk of prostate cancer to be 5.3 for the brothers of cases; for the 14,738 white subjects in the study, the relative risk was 7.8 (ref. 1). Prostate cancer risks for brothers were ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-848b

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2

Digitale Medien

Reply to “Euthanasia” (1995)

Radcliffe Richards, Janet

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 850-851

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The author replies — I do hope readers of Curtis's letter will go back and see what my article actually says. It is not a polemic. It does not even argue that voluntary euthanasia should be made legal, although my own provisional view is that it should. The argument is not about the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-850

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3

Digitale Medien

ApoE as a prognostic factor for post–traumatic coma (1995)

Sorbi, Sandro ; Nacmias, Benedetta ; Piacentini, Silvia ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 852-852

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor —Nicoll et al.1 explored the association between the ϵ4 allele of apolipoprotein E (apo E) and fatal head injuries in the February issue of Nature Medicine. Deposition of amyloid β-protein (Aβ) in the brain occurs in approximately one-third of individuals who die ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-852

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4

Digitale Medien

UK calls for regulation of genetic testing (1995)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 855-856

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Britain's beleaguered National Health Service (NHS) is coming under increasing pressure to develop a national strategy on the application and regulation of medical genetics. Initial attention, say proponents of such a strategy, should focus on the overall provision and monitoring of genetic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-855a

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5

Digitale Medien

Man-made chemicals and reproductive health (1995)

Moran, Nuala

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 857-857

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] There is plenty of circumstantial evidence to link synthetic chemicals that mimic oestrogens to falling sperm counts, abnormalities of the male reproductive system and increases in the number of cases of breast cancer, according to a UK government report published in late July. The report, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-857a

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6

Digitale Medien

Australian gene technology survey (1995)

Ban, Elizabeth

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 857-857

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Most Australians approve of the use of genetic engineering, with a person's social background having little effect on its acceptance, according to a recent study commissioned by the government and carried out by researchers at the Australian National University in Canberra. The study, Public ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-857b

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7

Digitale Medien

Familial Alzheimer's chromosome 14 mutations (1995)

Wasco, W. ; Pettingell, W.P. ; Jondro, P.D. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 848-848

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor —Five apparently pathogenic mutations in the gene S182 on chromosome 14 (ref. 1) and another mutation in a homologous gene, STM-2, on chromosome 1 (ref. 2), appear to cause early-onset (〈65 years) forms of familial Alzheimer's disease (FAD). We have found two new and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-848a

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8

Digitale Medien

Diphtheria disaster relief (1995)

Arya, Subhash C.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 851-852

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — Your news article “Diphtheria disaster relief” (Nature Medicine I (June), 503; 1995) discussed the relatively recent spread of diphtheria in the New Independent States (NIS) of the former Soviet Union. There is no reason to expect that this monstrous epidemic will ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-851b

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9

Digitale Medien

Keeping a lid on marijuana research (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 853-854

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Can smoked marijuana be good medicine? A debate over the answer to this question has carried through the better part of the twentieth century. Far from reaching any consensus, the debate has only grown more contentious. Most recently, efforts by Donald Abrams and his collaborators at the Community ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-853

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10

Digitale Medien

Gene therapy debuts in Japan (1995)

Nathan, Richard

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 856-856

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] With considerable media fanfare, gene therapy has at last made its debut in Japan five years after the first human gene therapy trial took place in the United States. In early August, doctors at Hokkaido University School of Medicine in northern Japan began treatment of a 4-year-old boy suffering ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-856

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11

Digitale Medien

Residency slots at teaching hospitals eyed for cutbacks (1995)

Sauber, Colleen M.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 858-858

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] These are uncertain times for US teaching hospitals. Faced with increased competition from less-expensive community hospitals, potential cuts in government Medicare spending and cuts in federal funding for graduate medical education, teaching hospitals are restructuring. They are cutting staff or ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-858

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12

Digitale Medien

Orphan drug tax credit renewal (1995)

Nasto, Barbara

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 860-860

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Legislation that would extend and make permanent a tax credit programme intended to benefit companies developing drugs to treat rare diseases could fall victim to the partisan politics that often precede a US presidential election. Nancy Johnson and Orrin Hatch call for permanent tax credit for ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-860b

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13

Digitale Medien

Did you know? (1995)

Jayaraman, K.S.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 861-861

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] India to get advanced warning system for disease outbreaks After last year's outbreak of plague took the country by surprise, the Indian government has decided to set up —with $25 million in World Bank assistance —a disease surveillance network that it hopes will provide advance ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-861c

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14

Digitale Medien

New global AIDS programme trying to break with the past (1995)

Tastemain, Catherine

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 862-862

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nine months or so after its formation, the policies of the new Joint United Nations Programme on HIV-AIDS (UNAIDS) are beginning to take shape. When it is fully operational some time next year, UNAIDS will coordinate international AIDS control and supercede the soon-to-be-defunct Global Programme ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-862a

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15

Digitale Medien

Industry blasts FDA disclosure rules (1995)

Fox, Jeffrey L.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 862-863

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] With little or no fanfare, the US National Institutes of Health (NIH) and the US National Science Foundation (NSF) in mid-July issued final regulations on “Objectivity in Research,” requiring investigators to disclose financial interests that might “ directly and significantly ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-862b

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16

Digitale Medien

Did you know? (1995)

Nathan, Richard

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 861-861

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] PC or not PC: That is the question Political correctness reached the doors of Japan's Ministry of Health and Welfare in August when an advisory panel to the ministry recommended changing terminology used to describe people with mental disabilities. The ministry, one of Japan's most conservative, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-861e

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17

Digitale Medien

Genetic origins of protein shape and interaction rules (1995)

Blalock, J. Edwin

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 876-878

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] One of Nature's great unsolved mysteries concerns the rules that govern protein folding and interaction. Specifically, is there a relationship between primary sequence and tertiary or quarternary structure? To quote Branden and Tooze, “The first crystallographic structural results on a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-876

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18

Digitale Medien

Unpleasant pain evoked by thalamic stimulation (1995)

Price, Donald D.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 885-887

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Classical medical textbook versions of ascending central pathways for pain teach that the spinothalamic system can be functionally subdivided into two components1–3: (1) a lateral ascending projection to the ventroposterior lateral nucleus of the thalamus and hence to somato-sensory cortex, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-885

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19

Digitale Medien

The antisense homology box: A new motif within proteins that encodes biologically active peptides (1995)

Baranyi, Lajos ; Campbell, William ; Ohshima, Kunihiro ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 894-901

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Amphiphilic peptides approximately fifteen amino acids in length and their corresponding antisense peptides exist within protein molecules. These regions (termed antisense homology boxes) are separated by approximately fifty amino acids. Because many sense–antisense peptide pairs have been ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-894

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20

Digitale Medien

HIV and CD26 (1995)

Dalgleish, Angus

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 881-882

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Like many other T-cell molecules, CD26 is associated with HIV disease progression1. Some molecules (CD38 and CD57) increase on T cells with disease progression, whereas other molecules (CD26, CD28 and CD45RA) decrease2,3. In this issue of Nature Medicine, Oravecz et al.4 describe studies in which ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-881

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21

Digitale Medien

Immunomodulation to enhance gene therapy (1995)

Wilson, Christopher ; Kay, Mark A.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 887-889

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] As studies in animal models and in limited human trials have begun to reveal, major impediments remain to be overcome if gene therapy is to become a reality. This is becoming increasingly clear in studies related to cystic fibrosis, where two major issues remain to be resolved: (1) the development ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-887

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22

Digitale Medien

A picornaviral protein synthesized out of frame with the polyprotein plays a key role in a virus–induced immune–mediated demyelinating disease (1995)

Chen, Hsiao-Huei ; Kong, Wing-Pui ; Zhang, Liang ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 927-931

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The DA strain and other members of the TO subgroup of Theiler's murine encephalomyelitis virus (TMEV) induce a chronic demyelinating disease with a restricted virus expression. This disease serves as an experimental model of multiple sclerosis; in both diseases the immune system contributes to a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-927

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23

Digitale Medien

Overexpression of the obese ( ob ) gene in adipose tissue of human obese subjects (1995)

Lönnqvist, Fredrik ; Arner, Peter ; Nordfors, Louise ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 950-953

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Obesity is accompanied by complications such as hypertension, non–insulin–dependent diabetes mellitus and atherosclerosis, which in turn cause ischaemic heart disease, stroke and premature death1–3. The underlying mechanisms behind imbalance in energy intake and energy expenditure ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-950

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24

Digitale Medien

This Is Our Work: The Legacy Of Sir William Osler (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 959-959

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] by Ted Grant 5 Span Books Pakenham, Ontario, Canada, KOA 2XO Canadian $145.00 ISBN: 0-9698568-0-6 Reviewed by Victor A. Mckusick (Osler Professor of Medicine, 1973–1985) The Johns Hopkins University School of Medicine Baltimore, Maryland 21287-4922 William Osler was without ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-959

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25

Digitale Medien

Reports of Note (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 963-963

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Parasitic Diseases in Water Resources Development: The Need for Intersectoral Negotiation The World Health Organization recently published a report on the imminent threat of parasitic diseases in water. Parasitic Diseases in Water Resources Development: The Need for Intersectoral Negotiation was ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0995-963

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26

Digitale Medien

Plague strain puzzler (1995)

Jayaraman, K.S.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 724-724

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Data from the United States, France and Russia seem to suggest that an entirely new strain of Yersinia pestis was responsible for last year's pneumonic plague outbreak in Surat, India, in which 44 people died. The news is cause for concern at the Indian health ministry where officials are now ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-724b

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27

Digitale Medien

Reply to : Bromocriptine in the treatment of alcoholics (1995)

Noble, Ernest P. ; Lawford, Bruce R. ; Syndulko, Karl

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 720-721

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Noble et al. reply — Evidence in the literature indicates that bromocriptine does not manifest its effect on craving in alcoholics until after three weeks of treatment. A similar lag period is also found in the action of other psychoactive medications including antidepressants and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-720c

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28

Digitale Medien

More sober research … (1995)

Pardes, Herbert

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 722-722

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — While agreeing with Barbara Culliton's call for ways to foster more daring or innovative efforts in science (Nature Medicine 1, 601), I hasten to add some words of caution. Not all worthy research is the result of spectacular insights or approaches. The establishment of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-722a

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29

Digitale Medien

CDC and Congress at odds over mandatory HIV testing (1995)

Touchette, Nancy

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 723-724

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Just about everyone would like to prevent the spread of AIDS to children but few agree on the best public policies to achieve this goal. Last year, researchers found that the antiviral drug zidovudine (AZT) drastically reduces the rate of transmission of the human immunodeficiency virus (HIV) from ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-723

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30

Digitale Medien

Transfection and malaria (1995)

Wesson, Dawn M. ; Krogstad, Donald J.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 745-747

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The natural transmission of malaria is a complicated phenomenon. It requires a reservoir of infected (parasitemic) humans, their exposure to feijiale anopheline mosquitoes capable of transmitting the Plasmodium parasite, aikd a pool of susceptible humans. Yet despite the complexities of this life ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-745

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31

Digitale Medien

Spectacle lenses alter eye growth and the refractive status of young monkeys (1995)

Hung, Li-Fang ; Crawford, M.L.J. ; Smith, Earl L.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 761-765

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The influence of visual experience on ocular development in higher primates is not well understood. To investigate the possible role of defocus in regulating ocular growth, spectacle lenses were used to optically simulate refractive anomalies in young monkeys (for example, myopia or ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-761

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Human retroviruses in the second decade: A personal perspective (1995)

Gallo, Robert C.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 753-759

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Human retroviruses have developed novel strategies for their propagation and survival. A consequence of their success has been the induction of an extraordinarily diverse set of human diseases, including AIDS, cancers and neurological and inflammatory disorders. Early research focused on their ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-753

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Health insurance debate stirs trouble for genetic testing (1995)

Gavaghan, Helen

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 733-733

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] “The devil will be in the details,” said Francis Collins, who heads the US National Institutes of Health's (NlH's) National Center for Human Genome Research. And it was. Collins was speaking at a meeting last month on the potential for discrimination by health-care insurers against ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-733a

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Digitale Medien

Monkey eyes grow into focus (1995)

Wallman, Josh ; Mcfadden, Sally

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 737-739

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Is myopia a disease or does it result from the eye's being tricked into thinking it is farsighted and attempting to compensate? Normal eyes are guided; perhaps by vision, from the hyperopia (farsightedness) or myopia generally present at birth toward emmetropia (the condition of a perfect match ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-737

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Digitale Medien

Metastases suppressors and prostate cancer (1995)

Petrylak, Daniel P.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 739-740

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In 1995, there will be 244,000 1cases of prostate cancer diagnosed in the United States — 44,000 more cases than in 1994— making it the most common cancer diagnosed in men. This increased incidence is attributable, at least in part, to aggressive screening by primary care physicians, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-739

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Digitale Medien

Rational cancer therapy (1995)

Lowy, Douglas R. ; Willumsen, Berthe M.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 747-748

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Cancer research conducted over the past two decades has determined that the abnormal growth properties of tumour cells usually result from a series of mutatipnal events that include activation of oncogenes and inactivation of tumour suppressor genes1. In theory, the molecular identification of the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-747

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Digitale Medien

Evidence of an X-linked or recessive genetic component to prostate cancer risk (1995)

Monroe, Kristine R. ; Yu, Mimi C. ; Kolonel, Laurence N. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 827-829

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We used data from a population-based cohort study of blacks, Hispanics, Japanese and whites to examine the frequency of prevalent prostate and breast cancer by family history status of first-degree relatives (parents and siblings). Independent of race, the age-adjusted relative risk for prevalent ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-827

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Digitale Medien

Vital Dust Life As A Cosmic Imperative (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 833-834

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] by Christian de Duve Basic Books, A Division of HarperCollins Publishers, New York, $25.00. Reviewed by Alexander G. Bearn The Rockefeller University, New York, New York 10021-6399 This captivating and impeccably crafted book by Christian de Duve is a magisterial account of the origin ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-833

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Digitale Medien

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice (1995)

Kohl, Nancy E. ; Omer, Charles A. ; Conner, Michael W. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 792-797

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] For Ras oncoproteins to transform mammalian cells, they must be post-translationally modified with a farnesyl group in a reaction catalysed by the enzyme farnesyl-protein transferase (FPTase). Inhibitors of FPTase have therefore been proposed as anti-cancer agents. We show that L-744,832, which ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-792

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Digitale Medien

Enzyme-independent formation of nitric oxide in biological tissues (1995)

Zweier, Jay L. ; Wang, Penghai ; Samouilov, Alexandre ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 804-809

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The gaseous free radical nitric oxide (NO˙) is an important regulator of a variety of biological functions and also has a role in the pathogenesis of cellular injury. It has been generally accepted that NO˙ is solely generated in biological tissues by specific nitric oxide synthases, NOSs, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-804

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Digitale Medien

Stedman's Plus, Version 3.0 ELECTRONIC SPELL-CHECKING PACKAGE (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 835-835

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Williams & Wilkins Electronic Media, Baltimore, Maryland 21202-3993, 1995, $99.00. Reviewed by Barbara P. Ordway Assistant Editor, Copy, Nature Medicine Stedman's Plus, Version 3.0, is an electronic spell-checking package based on medical vocabulary and drug names as well as ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0895-835

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Digitale Medien

Rats, rats, rats! (1995)

Dupré, Roslyn M.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 609-609

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] During the past year, rumours have abounded of increasing rat populations in several large cities. From New York to Washington and Warsaw to London local papers have carried stories citing anecdotal evidence of increased rat sightings, infestations, and even rat attacks. In urban areas, the chief ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-609a

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Digitale Medien

Euthanasia (1995)

Richards, Janet Radcliffe

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 618-620

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Earlier this year in Britain we had our first experience of voluntary euthanasia live, as it were, in a Dutch television film. It was deeply distressing, but only because the story was one that could not have had a happy ending; the ending it had was the least unhappy there could have been. The man ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-618

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Digitale Medien

Methylation and p16 : Suppressing the suppressor (1995)

Little, Melissa ; Wainwright, Brandon

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 633-634

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It is nearly a quarter of a century since cancer genetics embraced the ‘ two-hit’ model of Knudson and Strong, in which both copies of a tumour suppressor gene need to become inactivated for tumorigenesis to occur1. This model was very convincingly demonstrated to be true for the Rbl ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-633

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Prevention of breast tumour development in vivo by downregulation of the p185 neu receptor (1995)

Katsumata, Makoto ; Okudaira, Tadao ; Samanta, Arabinda ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 644-648

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Certain strains of transgenic mice that express the rat neu oncogene (neuT) in mammary epithelial cells develop breast tumours at an average of 44 weeks of age. In this study, intraperitoneal injection of a monoclonal anti-receptor antibody specific for the rat neuT oncogene product dramatically ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-644

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Targeting antigen into the phagocytic pathway in vivo induces protective tumour immunity (1995)

Falo, L.D. ; Kovacsovics-Bankowski, M. ; Thompson, K. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 649-653

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Cytotoxic T lymphocytes (CTLs) kill neoplastic or virally infected cells after recognizing on their surface antigenic peptides bound to major histocompatibility complex class I molecules. These peptides are derived from antigens that are degraded in the cytosol of the affected cell. Because ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-649

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Intracellular expression of antibody fragments directed against HIV reverse transcriptase prevents HIV infection in vitro (1995)

Maciejewski, Jaroslaw P. ; Weichold, Frank F. ; Young, Neal S. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 667-673

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We have tested a novel strategy of intracellular immunization to block human immunodeficiency virus (HIV) infection. The expression of a specific antibody within a cell was achieved by transduction of genes that encode for immunoglobulin chains with specificity to viral reverse transcriptase. We ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-667

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Neutralization of HIV-1 by secretory IgA induced by oral immunization with a new macromolecular multicomponent peptide vaccine candidate (1995)

Bukawa, Hiroki ; Sekigawa, Ken-Ichiro ; Hamajima, Kenji ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 681-685

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Control of pandemic infection of human immunodeficiency virus type 1 (HIV-1) requires some means of developing mucosal immunity against HIV-1 because sexual transmission of the virus occurs mainly through the mucosal tissues. However, there is no evidence as yet that the secretory immunoglobulin A ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-681

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Digitale Medien

Serum p53 antibodies as early markers of lung cancer (1995)

Lubin, Richard ; Zalcman, Gerard ; Bouchet, Laurence ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 701-702

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The p53 alteration is the most common alteration found in human cancer. It usually involves missense mutations that stabilize the p53 protein, which in turn accumulates, reaching levels detectable by immunohistochemistry. We1–4 and others5–8 have demonstrated that this overexpression of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-701

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Digitale Medien

A role for a new herpes virus (KSHV) in different forms of Kaposi's sarcoma (1995)

Schalling, Martin ; Ekman, Marianne ; Kaaya, Ephata E. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 707-708

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Kaposi's sarcoma (KS) is a previously rare, tumour-like lesion of controversial biological nature1,2. KS has since the early 1980s become frequent in patients with AIDS, particularly in homosexuals3. KS is also endemic in Central Africa predominantly in otherwise healthy men but also in women and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-707

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Digitale Medien

On The Market (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 713-716

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] REAGENTS AND MARKERS Endothelin-1 immunoassay. The Parameter endothelin-1 ELISA from R&D Systems is intended to provide a precise measurement of extracted and reconstituted human plasma samples. The immunoassay is said to offer reproducible results across a sample range of 1–30 pg ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0795-713

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Digitale Medien

Psychiatry disabused (1995)

Spiegel, David

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 490-491

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — “Psychiatry abused” ran the intriguing teaser on the cover of the February 1995 issue of Nature Medicine for an article by Paul McHugh1. This title turned out to be quite an accurate description of the article itself, but for a different reason than that which was ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-490

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Reply to : Psychiatry disabused (1995)

McHugh, Paul R.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 492-492

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] McHugh replies — I asserted that psychiatry is a medical discipline vulnerable to faddish errors. My correspondents illustrate how such errors arise. Dr. Spiegel's letter has many examples. I shall only comment on two. He says “psychiatry did not create dissociation.” This is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-492a

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Digitale Medien

The PKD1 gene product (1995)

Harris, Peter C. ; Germino, Gregory ; Klinger, Kathy ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 493-493

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — We would like to bring to your attention a report1 that has significant implications for an autosomal dominant polycystic kidney disease study that was reported in the April issue of Nature Medicine2. This study described the characterization and localization of an ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-493a

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Digitale Medien

Is there a future for clinical PET? (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 494-495

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In spite of the promise of positron emission tomography (PET) as a non-invasive diagnostic imaging tool that can provide a window into the workings of the human body, the technology has been slow to move from the bench to the clinic. Two issues have dogged PET: reimbursement by third-party payors, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-494

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Shroud shrouded in biofilm (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 495-495

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Shroud of Turin, which is reputed to be the burial cloth of Jesus Christ, is encased in a biofilm produced by microbes. Researchers from the University of Texas Health Sciences Center at San Antonio report that salt-tolerant, alkali-resistant microbes have also been isolated from the shroud ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-495c

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Rational drug design and HIV: Hopes and limitations (1995)

Goody, Roger S.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 519-520

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Progress during the past few decades in understanding both the structures of biological macromolecules and the manner in which they interact with each other — and with small molecules — has engendered high hopes for the rational design of substances aimed at specific molecules or ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-519

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Exploit, don't compromise, research (1995)

Moran, Nuala

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 499-499

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A grand coalition of British academics is fighting back against what they see as a threat to their intellectual freedom, namely increasing pressure from the UK government and industry to direct research into commercially productive areas. This, they say, is undermining the ability of universities ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-499b

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59

Digitale Medien

Clotrimazole inhibits cell proliferation in vitro and in vivo (1995)

Benzaquen, Laura R. ; Brugnara, Carlo ; Byers, H. Randolph ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 534-540

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Cell proliferation is critically dependent on the regulated movement of ions across various cellular compartments. The antimycotic drug clotrimazole (CLT) has been shown to inhibit movement of Ca2+ and K+ across the plasma membrane. Our results show that CLT inhibits the rate of cell proliferation ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-534

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60

Digitale Medien

Isolation of novel virus-like sequences associated with human hepatitis (1995)

Simons, John N. ; Leary, Thomas P. ; Dawson, George J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 564-569

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Two viruses, GB virus A (GBV-A) and GB virus B (GBV-B), were recently identified in the GB hepatitis agent. Human sera containing antibodies that recognize GBV-A and/or GBV-B recombinant proteins were subjected to polymerase chain reaction studies with degenerate oligonucleotides capable of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-564

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The role of clinical research (1995)

Holsboer, Florian

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 492-493

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — I applaud your editorial on the increasing endangerment of clinical research and the physician-scientist. In my present position as director of a large research complex with 120 research beds and a mix of over 100 clinical and preclinical researchers all devoted to studying ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-492b

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Blood safety (1995)

Potocnik, Marjeta

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 493-493

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor — In the article “Making global blood safety a priority”, it was stated that in developing countries testing of donated blood for HIV was insufficient or of poor quality. There was a map illustrating the situation in 1992. Slovenia was presented as part of the former ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-493c

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Too Many People (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 590-590

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] By Roy Calne Riverrun Press, Inc., New York, 1995 $15.95 Reviewed by Adrian J. Ivinson Too Many People is almost as much about the author as his subject. Knighted for his services to medicine, Roy Calne has a reputation, worldwide, as one of the best and most innovative transplant ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-590

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Senators voice frustration, White House proposes reform of FDA (1995)

Gavaghan, Helen

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 390-390

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The White House entered into the hullabaloo surrounding the way that the US Food and Drug Administration (FDA) does business when last month it released its own proposals for reform of the agency. The ‘white paper’ adds the administration's voice to a debate that is attracting ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-390

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Chemical generation of nitric oxide in the mouth from the enterosalivary circulation of dietary nitrate (1995)

Duncan, Callum ; Dougall, Hamish ; Johnston, Peter ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 546-551

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] High concentrations of nitrite present in saliva (derived from dietary nitrate) may, upon acidification, generate nitrogen oxides in the stomach in sufficient amounts to provide protection from swallowed pathogens. We now show that, in the rat, reduction of nitrate to nitrite is confined to a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-546

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A Miracle and a Privilege Recounting a half century of surgical advance (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 588-588

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] By Francis D. Moore Joseph Henry Press, Washington, DC,1995 $29.95 Reviewed by James J. Ferguson JR Francis Moore arrived on the threshold of medicine at the right time and place for expressing his many skills. In the mid-forties, fundamental science, much derived from wartime ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-588

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Multidrug resistance: Locked in the vault? (1995)

Rome, Leonard H.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 527-527

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The discovery that multidrug resistance could be explained by transmembrane transporter molecules (MRP and PgP) acting as pumps to remove toxic drugs was soon followed by the realization that some tumours resisted chemotherapy by an alternate mechanism. The article by Scheffer et al. in this issue ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-527

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Inhibition of cellular ras prevents smooth muscle cell proliferation after vascular injury in vivo (1995)

Indolfi, Ciro ; Avvedimento, Enrico V. ; Rapacciuolo, Antonio ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 541-545

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Proliferation of smooth muscle cells of the arterial wall in response to local injury is an important aetiologic factor of vascular proliferative disorders such as atherosclerosis and restenosis after angioplasty. Ras proteins are key transducers of mitogenic signals from membrane to nucleus in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-541

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γδ T cell-induced nitric oxide production enhances resistance to mucosal candidiasis (1995)

Jones-Carson, Jessica ; Vazquez-Torres, Andres ; van der Heyde, Henri C. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 552-557

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Despite the prevalence of γδ T cells in mucosae that are typically colonized by Candida albicans, little is known of the possible role of these cells in resistance to candidiasis. A sharp increase in the number of γδ T cells and macrophages following intraperitoneal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-552

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Anti-CD44 treatment abrogates tissue aedema and leukocyte infiltration in murine arthrtis (1995)

Mikecz, Katalin ; Brennan, Frank R. ; Kim, Jonathan H. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 558-563

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A ubiquitous cell adhesion receptor, CD44, preferentially binds hyaluronan, a poly-saccharide macromolecule that is present in most extracellular matrices. Hyaluronan molecules have large hydrodynamic volumes that entrap substantial amounts of water and can therefore control tissue hydration ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-558

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Clinical center overhaul: Common cents? (1995)

Touchette, Nancy

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 391-391

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Advice columnist Ann Landers and common sense often dictate: “If it ain't broke, don't fix it.” But a proposal under consideration at the US National Institutes of Health (NIH) has researchers and administrators wondering just what the problem is. At issue is an effort spearheaded by ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-391a

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A shot in the arm for gene therapy company (1995)

Gavaghan, Helen

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 392-392

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A patent covering all ex vivo gene therapy that was issued last month to the US National Institutes of Health (NIH) rocked both the academic world and the biotechnology industry. Reactions ranged from criticisms that it was too broad or too obvious, to fears that it would hold back progress within ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-392

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73

Digitale Medien

Photosensitive Epilepsy New edition (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 589-590

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Clinics in developmental medicine, No. 133 By Graham F.A. Harding and Peter M. Jeavons London: MacKeith Press, 1994 $59.95 Reviewed by Ronald P. Lesser As with many diseases, one of the most fascinating features of epilepsy is its variety: not epilepsy but the epilepsies, a house with a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-589

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Genome engineering: the new mouse genetics (1995)

Rossant, Janet ; Nagy, Andras

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 592-594

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The field of mouse genetics has been forever changed by the advent of embryonic stem (ES) cell technology. ES cells are derived from the early mouse embryo and can be maintained indefinitely in culture in an undifferentiated state. However, upon return to the environment of the early embryo, they ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0695-592

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Genes and discrimination (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 385-385

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] No one talks about the sense of excitement and hope that accompanies the steady progress in human genetics without mentioning in the same breath the notion than molecular genetics poses unique ethical issues. Medicine's ability to identify in healthy people genes that may predispose them to future ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-385

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Reply to : Apoptosis and HIV disease (1995)

Finkel, Terri H. ; Monks, Colin ; Casella, Carolyn ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 387-387

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Finkel et al. reply — We found that most apoptotic cells were uninfected, consistent with an innocent bystander mechanism of cell death. The numerical estimates of Lu & Andrieu support this interpretation. However, we disagree with their interpretation of the recent data of Wei et al.2, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-387

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Harold M. Weintraub, 1945–1995 (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 389-389

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Dr. Harold M. Weintraub, 49, a prominent developmental and molecular biologist, died on 28 March at the Fred Hutchinson Cancer Research Center in Seattle, Washington, of complications from glioblanoma. “Hal was a mentor to those of that had the privilege of working with him,” said ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-389b

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Italian medical association to curb assisted-reproduction practices (1995)

Tastemain, Catherine

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 391-391

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Just a coincidence? Pope John Paul II's Evangelium Vitae, lambasting contraception, medically assisted procreation and experiments on human embryos, was released at the same time as the Italian Council of Doctors' (the official medical association of Italy) decision to regulate medically assisted ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-391b

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The essential roles of parenchymal tissues and passenger leukocytes in the tolerance induced by liver grafting in rats (1995)

Sriwatanawongsa, Voravit ; Davies, Hugh ff. S. ; Calne, Roy Y.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 428-432

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Liver allografts in pigs and rodents are uniquely capable of inducing tolerance to themselves and to other grafts of donor tissues, instead of succumbing to the acute rejection that follows transplantation of other allogeneic tissues. We demonstrate here, using normal and chimaeric rat liver ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-428

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Anatomical research lives! (1995)

Thompson, Van P.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 297-298

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The announcement of a new anatomical finding is astonishing during these times of re-evaluation and closing of anatomy departments in medical anddental schools. This is particularly true if such a finding helps explain the relationship between headache and muscle tension, a highly controversial ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-297

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CTL to HIV-1: Surrogates or sirens (1995)

Mathieson, Bonnie J.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 304-305

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The recognition that cytotoxic T lymphocytes (CTL) might be an important surrogate marker or correlate for immune protection against HIV-1 infection or disease has gradually evolved. Several observations have supported the incorporation of CTL induction as a goal in HIV-1 vaccine design. First, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-304

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Positive selection in autoimmunity: Abnormal immune responses to a bacterial dnaJ antigenic determinant in patients with early rheumatoid arthritis (1995)

Albani, Salvatore ; Keystone, Edward C. ; Nelson, J. Lee ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 448-452

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A novel ‘multistep molecular mimicry’ mechanism for induction of rheumatoid arthritis (RA) by bacterial antigens that activate T lymphocytes previously ‘educated’ by peptides derived from a class of human histocompatibility antigens is reported here. These antigens have the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-448

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Gene Therapy: A Handbook for Physicians (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 479-479

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] By Kenneth W. Culver Mary Ann Liebert Inc., 1994 $Price Reviewed by James J. Ferguson Jr Some years ago Alvin Toffler, in his popular book Future Shock, offered the thesis that the social and technical complexities imposed by progress may be overwhelming our capacity to deal with them. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-479

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84

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CD40 ligand has potent antiviral activity (1995)

Ruby, Janet ; Bluethmann, Horst ; Aguet, Michel ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 437-441

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] For B cells to make antibodies against most antigens, they require help from T cells. T cell help is delivered as two signals to the B cell, one of which is via CD40 and the other can be through receptors for any of a variety of soluble cytokines. We have constructed recombinant vaccinia viruses ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-437

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A placental clock controlling the length of human pregnancy (1995)

McLean, Mark ; Bisits, Andrew ; Davies, Joanne ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 460-463

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We report the existence of a ‘placental clock’, which is active from an early stage in human pregnancy and determines the length of gestation and the timing of parturition and delivery. Using a prospective, longitudinal cohort study of 485 pregnant women we have demonstrated that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-460

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Ischaemia-induced expression of bFGF in normal skeletal muscle: A potential paracrine mechanism for mediating angiogenesis in ischaemic skeletal muscle (1995)

Walgenbach, Klaus J. ; Gratas, Catherine ; Shestak, Kenneth C. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 453-459

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To test the hypothesis that induction of endogenous bFGF can lead to angiogenesis in ischaemic skeletal muscle, we studied the expression of bFGF after transposition of a well-vascularized muscle flap onto an ischaemic hindlimb in the rabbit. The results indicated a marked induction of bFGF mRNA ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-453

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Ovarian Cancer: Screening, treatment and followup 1994 (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 480-480

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Ovarian cancer is a leading cause of death from gynaecologic malignancies among women. In the past few years, significant new information has been generated regarding the epidemiology, biology, risk reduction, screening, treatment and follow-up of ovarian cancer. The National Cancer Institute ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0595-480

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Clinical investigation: An endangered science (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 281-281

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] A decade ago, James B. Wyngaarden, a former director of the US National Institutes of Health (NIH), struck a resonant chord in the world of biomedical research when he wrote about the physician-scientist as an “endangered species”. Throughout the history of medicine, physicians who ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-281

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89

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Molecular foundations of cancer: New targets for intervention (1995)

Karp, Judith E. ; Broder, Samuel

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 309-320

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Conceptual and practical advances in molecular medicine are changing our understanding of cancer pathogenesis. In time this should provide the opportunity to alter the natural history of many ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-309

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Transfer of HIV-1-specific cytotoxic T lymphocytes to an AIDS patient leads to selection for mutant HIV variants and subsequent disease progression (1995)

Koenig, Scott ; Conley, Anthony J. ; Brewah, Yambasu A. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 330-336

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] An HIV-1-seropositive volunteer was infused with an expanded autologous cytotoxic T lymphocyte (CTL) clone directed against the HIV-1 net protein. This clone was adoptively transferred to determine whether supplementing CTL activity could reduce viral load or improve clinical course. Unexpectedly, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-330

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91

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Long-term delivery of a lysosomal enzyme by genetically modified fibroblasts in dogs (1995)

Moullier, Philippe ; Bohl, Delphine ; Cardoso, Jorge ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 353-357

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We have evaluated the feasibility and efficacy of intraperitoneal implants (neo-organs) for protein delivery in large animals. Skin biopsies were taken from four healthy dogs. Primary fibroblast cultures were transduced with a retroviral vector coding for the human β-glucuronidase. One to six ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-353

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92

Digitale Medien

The Hostage Brain (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 377-377

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] By Bruce S. McEwen & Harold M. Schmeck, Jr. The Rockefeller University Press 1994 $19.95 Reviewed by Charles Jennings Despite its enormous implications, brain research has yet to catch the public imagination in the way that, for example, astronomy has done. The Hostage Brain ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-377

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93

Digitale Medien

Reports of note (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 378-378

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] MEXICAN AND U.S. ACADEMIES PRESENT JOINT RESEARCH 1995 Two new reports resulting from a collaborative effort between the Mexican and United States Academies of Sciences and Engineering were released on March 20, 1995, in Mexico City. These reports are the first fruitful results of a newly combined ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0495-378

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94

Digitale Medien

Politics and genes (1995)

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 181-181

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Human germline therapy is in our future. Other once unimaginable forms of therapy have entered mainstream medicine. Just as surely the day will come when gene therapy, now confined to somatic cells, will extend to egg and sperm. The diseases of the parents will no longer be passed on to their ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0395-181

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95

Digitale Medien

Glaxo takeover bid : welcome or not? (1995)

Dickson, David

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 195-195

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The bid by Glaxo, Britain's largest pharmaceutical company, for its smaller rival Wellcome, has received a lukewarm response from both investors and the scientific community alike. The former, at least judging by initial share movements, remain to be convinced that a horizontal merger between two ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0395-195

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96

Digitale Medien

Radical directions in Parkinson's disease (1995)

Fisher, Lisa J. ; Gage, Fred H.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 201-203

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Parkinson's disease is characterized by a gradual deterioration of neurons that synthesize the neurotransmitter dopamine within the substantia nigra pars compacta of the brain. The resultant decrease of dopamine-containing fibers within the striatum (see Fig. 1a) is associated with several sensory ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0395-201

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97

Digitale Medien

Agalactosyl IgG and mannose-binding proteins: Biochemical nicety or pathophysiological paradigm? (1995)

Ezekowitz, R. Alan B.

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 207-208

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Why should there be a link between aberrant glycosylated immunoglobulins, the mannose-binding protein, complement activation, and rheumatoid arthritis? Experimental evidence that attempts to connect these is put forward by Malhotra and colleagues in this issue of Nature Medicine (pages 237-243)1. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0395-207

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98

Digitale Medien

Glycosylation changes of IgG associated with rheumatooid arthritis can activate complement via the mannose-binding protein (1995)

Malhotra, Rajneesh ; Wormald, Mark R. ; Rudd, Pauline M. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 237-243

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The glycosylation of the circulating immunoglobulin-γ (IgG) antibody molecules changes in rheumatoid arthritis. The extent of the changes correlates with the disease severity and reverses in remission. We demonstrate here that the alteration in glycosylation associated with rheumatoid ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0395-237

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99

Digitale Medien

Antifibrinolytic activity of apolipoprotein(a) in vivo : Human apolipoprotein(a) transgenic mice are resistant to tissue plasminogen activator-mediated thrombolysis (1995)

Palabrica, Theresa M. ; Liu, Alexander C. ; Aronovitz, Mark J. ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 256-259

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The extensive homology between apolipoprotein(a) and plasminogen has led to the hypothesis that the increased risk for atherosclerosis, cardiac disease and stroke associated with elevated levels of apolipoprotein(a) may reflect modulation of fibrinolysis. We have investigated the role of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0395-256

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100

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Induction of human autologous cytotoxic T lymphocytes on formalin-fixed and paraffin-embedded tumour sections (1995)

Liu, Shu Qin ; Saijo, Kaoru ; Todoroki, Takeshi ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 1 (1995), S. 267-271

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Human autologous tumour-specific cytotoxic T lymphocytes (CTL) were generated from peripheral blood on small formalin-fixed paraffin-embedded sections of a gastric cancer. The CTL killed live target cells at an effector/target ratio of 1 within 24 hours and showed the same target specificity as ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0395-267

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