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Chapter 15 Brain Tumors and the Lynch Syndrome (2021)

Peltomäki, Päivi ; Gylling, Annette

InTechOpen | Management of CNS Tumors | Management of CNS Tumors

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Publication Date: 2024-04-04

Description: Lynch syndrome (LS) (MIM No. 120435-6), previously known as hereditary nonpolyposis colorectal cancer (HNPCC) (Boland, 2005), is an autosomal dominant disorder caused by germline mutation in one of the DNA mismatch repair (MMR) genes. LS is among the most prevalent cancer syndromes in man and is estimated to account for 1-6% of all colorectal cancers (Lynch & de la Chapelle, 2003).

Keywords: brain tumors ; lynch syndrome ; brain tumors ; lynch syndrome ; Colorectal cancer ; DNA methylation ; DNA mismatch repair ; Gene ; Glioblastoma ; Glioma ; Hereditary nonpolyposis colorectal cancer ; Mutation ; Neoplasm ; thema EDItEUR::P Mathematics and Science::PD Science: general issues

Language: English

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