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  • Wiley  (66,643)
  • Oxford University Press  (26,635)
  • Nature Publishing Company
  • 1985-1989  (83,985)
  • 1935-1939  (11,052)
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Year
  • 101
    Electronic Resource
    Electronic Resource
    Claim Language in Biotechnology Patents (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 138-140 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Before the discovery of DNA or the creation of genetic engineering, Judge Learned Hand said that drafting good patent claims is one of the most difficult tasks in all of law. Molecular biology has added another layer, indeed another dimension, of tremendous complexity and difficulty to that job. ...
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    URL: http://dx.doi.org/10.1038/nbt0289-138
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  • 102
    Electronic Resource
    Electronic Resource
    Biotechnology in the Eastern Bloc (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 133-136 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Eastern European nations and the Soviet Union are lagging behind the West in one of today's key technologies—biotechnology. They have yet to produce human insulin commercially (which has been available in the West for six ,years), and there is no sign that, they are developing any of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0289-133
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  • 103
    Electronic Resource
    Electronic Resource
    Harnessing Biomolecules for Sensing (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 175-176 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Biosensors in their various forms share a reliance on biological materials as sensing elements. To date, only enzyme-based biosensors—in which a redox reaction occurring on a probe surface triggers an electrochemical signal—have been widely commercialized. In the next several years, ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt0289-175
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  • 104
    Electronic Resource
    Electronic Resource
    Syphilis Still a Diagnostic Dilemma (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 192-192 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] After all these years, there is still no truly reliable diagnostic for syphilis. In consequence, there is an epidemic increase in all stages of this disease in the United States. According to the Centers for Disease Control (CDC, Atlanta, GA), reported cases of syphilis in 1987 increased by 32 ...
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    URL: http://dx.doi.org/10.1038/nbt0289-192
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  • 105
    Electronic Resource
    Electronic Resource
    The Fractal Geometry of the Heart (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1219-1219 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO, Calif.—Understanding the bases, and predicting the onset, of the cardiac arrhythmias called ventricular fibrillation are two major goals of cardiology. As participants at this year's Biotech USA, held here in October, learned, applying mathematical chaos theory to cardiac ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1289-1219
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  • 106
    Electronic Resource
    Electronic Resource
    Later-Stage Financing in the Doldrums (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1224-1224 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN DIEGO, Calif.—The dearth of later-stage, pre-initial public offering financing clearly has biotech venture investors worried. Leading off the financing trends panel at September's Biopharmaceuticals '89 conference, co-sponsored by PaineWebber (New York, NY) and Bio/Technology, Stephen ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1289-1224
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  • 107
    Electronic Resource
    Electronic Resource
    HCFA, Insurers Urged to Pay for Test Drugs (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1228-1228 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Should insurers defray more of the expenses associated with caring for patients who are being treated with experimental drugs or with drugs explicitly approved only for other specific uses? Physicians, AIDS (acquired immunodeficiency syndrome) community activists, and some ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1289-1228a
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  • 108
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    Behind the Scenes of the MBI/Shionogi Strategic Alliance (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1242-1243 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An alliance with MBI allowed Shionogi to penetrate the market faster than it could have via internal ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1289-1242
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  • 109
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    Another Voice of Concern (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1248-1248 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: I would like to respond to your article entitled “Wide Acclaim for North Carolina Regulations.” (Bio/Technology 7:1002, Oct. '89). North Carolina, a dynamic and progressive state, has outstanding research and commercial ventures—both academic and ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1289-1248b
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  • 110
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    Protection Against Potyvirus Infection in Transgenic Plants: Evidence for Broad Spectrum Resistance (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1257-1262 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Expression in transgenic plants of the coat protein (CP) gene from a virus pathogenic to that plant confers protection to the plant against this or closely related viruses. To expand our understanding of the breadth of protection conferred by CP genes, transgenic tobacco plants were produced that ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1289-1257
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  • 111
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    Entrapment and Growth of Murine Hybridoma Cells in Calcium Alginate Gel Microbeads (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1275-1279 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have developed a gel entrapment process for the entrapment and growth of mu-rine hybridoma cells. This entrapment process takes advantage of the calcium-mediated gelation of sodium alginate. Mu-rine hybridoma cells entrapped within calcium alginate gel microbeads were shown to proliferate to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1289-1275
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  • 112
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    Green Matters (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1105-1105 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] About a year ago, a radio producer who was planning a program on the release of engineered organisms into the environment contacted me. Concerned about proposals to deploy modified baculoviruses against pests in Scottish pine forests, she had become deeply puzzled. The problem was this: A spokesman ...
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    URL: http://dx.doi.org/10.1038/nbt1189-1105
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  • 113
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    Dueling Monoclonals, NAS Release Report (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1107-1112 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Collision Course? The filing by Centocor (Malvern, PA) of a Product License Application (PLA) on its human monoclonal antibody (MAb) heats up the race to market products for treating gram-negative sepsis. The company now joins Xoma (Berkeley, CA) in attempting to harness MAbs to neutralize ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1189-1107
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  • 114
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    Using Antibodies to Increase Yields (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1118-1118 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—Agricultural and Food Research Council (AFRC) researchers are evolving two novel strategies for increasing milk yield and carcass weight in cows and other livestock. Exploiting the animals' own immune systems, the techniques may offer more convenient and acceptable alternatives to ...
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    URL: http://dx.doi.org/10.1038/nbt1189-1118
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  • 115
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    DNA Analysis Reunites Argentinian Families (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1126-1126 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO—Forensic DNA analysis, which is gaining a foothold in the United States as a tool for criminal investigations, is now helping to resolve political crimes in other countries. As University of California (Berkeley) geneticist Mary Claire King told attendees at the Biotech USA ...
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    URL: http://dx.doi.org/10.1038/nbt1189-1126
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  • 116
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    Production of Soluble Recombinant Proteins in Bacteria (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1141-1149 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Production of recombinant proteins in bacteria is limited by the formation of cytoplasmic aggregates (inclusion bodies or “IBs”). This review summarizes what is known about why IBs form and ways of increasing the production of soluble protein in bacterial systems. The easiest way to ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1189-1141
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  • 117
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    Genetic Fingerprinting for Yeasts (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1168-1170 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In this paper we describe two complementary approaches to a molecular taxonomy for the yeasts which exploit hybridisation to restriction fragments containing the repetitive sequence poly[dGdT.dCdA] (polyGT). This method will be of particular use to industrial users of the yeasts, whether they are ...
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    URL: http://dx.doi.org/10.1038/nbt1189-1168
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  • 118
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    New Products for Cell Culture (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1185-1187 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fermentation Gas Monitor The Fermentomax system from Columbus Instruments (Columbus, OH) optimizes glucose delivery to fermentors on the basis of respiratory quotient measurement by open-circuit calorimetry. Controlled glucose delivery optimizes biomass growth while minimizing feed waste. Write ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1189-1185
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  • 119
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    Capillary Electrophoresis (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1193-1193 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Several unfortunate typographical errors found their way into the recent article on Capillary Electrophoresis (Bio/Technology 7:903, Sept. '89). While some are obvious, several others are quite misleading and should be brought to the attention of your readers. In the table ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nbt1189-1193b
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  • 120
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    Wide Acclaim for North Carolina Regulations (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1002-1002 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—A recently enacted state-level bill to regulate the environmental introduction of genetically engineered organisms is being greeted with widespread enthusiasm—acclaimed by representatives of biotechnology companies and by environmentalists alike. Perhaps that's no ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1002
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  • 121
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    Biotech Business Guide Gives Little Guidance (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1007-1007 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Titled “Biotechnology Patents: a Business Manager's Legal Guide,” the first of a series of four Special Reports in the Bureau of National Affairs (BNA, Washington, DC) Series on Biotechnology falls short. While providing a fair description of the decade-old history of patent law as ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1007
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  • 122
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    The Chase for Venture Dollars (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1026-1028 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] While there's no shortage of venture capital dollars to finance biotechnology companies, some seem to get all the gold; others seem to get none. And although there's no system for “picking the winners” for investment dollars, there are certain markers that a venture capitalist can look ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1026
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  • 123
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    Expression of Tetanus Toxin Fragment C in E. coli: Its Purification and Potential Use as a Vaccine (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1043-1046 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Fragment C is a 50 kD non-toxic polypeptide that is one of the products of cleavage of tetanus toxin by papain. A 90 kD fusion protein containing fragment C when expressed in E. coli was insoluble. In contrast, a polypeptide exactly corresponding to fragment C was expressed in E. coli, in a soluble ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1043
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  • 124
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    Plantlet Regeneration from Embryogenic Protoplasts of White Spruce (Picea Glauca) (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1060-1062 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We report plantlet regeneration from conifer protoplasts. White spruce protoplasts were isolated from previously cryopreserved embryogenic suspension cultures and cultured in PCM with an osmoticum containing myo-inositol. Protoplast derived embryos established in suspension culture, were used as ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1060
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  • 125
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    Recombinant Streptomyces Lividans Secretes a Fusion Protein of Tendamistat and Proinsulin (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1055-1059 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We expressed a secreted protein fusion containing the complete α-amylase inhibitor of Streptomyces tendae (tendamistat, HOE 467) and proinsulin from the monkey, Macaca fascicularis, in Streptomyces lividans. The proinsulin gene was fused downstream of the tendamistat gene and separated by a ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1055
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  • 126
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    High Frequency Transformation of Whole Cells of Amino Acid Producing Coryneform Bacteria Using High Voltage Electroporation (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1067-1070 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have investigated the use of high voltage electroporation to introduce plasmid vectors into several of the amino-acid producing corynebacteria. We report very successful transformation of plasmids into Corynebacterium glutamicum, Brevibacterium lactofermentum and several other species of these ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1067
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  • 127
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    Efficient Extracellular Expression of a Foreign Protein in Streptomyces Using Secretory Protease Inhibitor (SSI) Gene Fusions (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1063-1066 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Using the gene for a secreted protease inhibitor, Streptomyces subtilisin inhibitor (SSI), we have established a secretory expression system for the products of foreign genes in Streptomyces. A sex pheromone peptide, cADl, of Enterococcus faecalis was expressed and secreted as a stable complete ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1063
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  • 128
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    Microsequencers for Proteins and Oligosaccharides (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1075-1076 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In analyzing the basic structure of proteins and their glycoconjugates, both academic and industrial researchers are subject to constraints on the amount of sample available. Basic researchers may be interested in an in vivo protein produced sporadically in small quantities. Entrepreneurs may have ...
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  • 129
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    Microsequencing Products (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1077-1077 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Glycoprotein Analysis BioCarb Chemicals of Lund, Sweden, offers structural analysis of glycoproteins through its new Glycoprint method. By denning the identity of each glycoprotein, the service gives researchers valuable technical data for product development as well as patent applications. Write ...
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  • 130
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    Free Literature (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1086-1086 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Peptides. The 1989 Peptides Catalog from Sigma Chemical (St. Louis, MO) lists 600 high-purity, synthetic bioactive peptides with agonist or antagonist effects. This source organizes bioactive peptides, small peptides and substrates, and polyamino acids into 19 categories with listings containing ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1086
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  • 131
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    New Products (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1078-1084 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Color Analysis Software Shimadzu (Columbia, MD) announces new software for its UV2100 UV-visible and UV3100U UV-Vis-NIR spectrophotometers. Able to calculate values for transmission or reflection automatically, the software includes weighting coefficients for illuminants and corrects for sample ...
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    URL: http://dx.doi.org/10.1038/nbt1089-1078
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  • 132
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    Announcements (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1088-1088 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] OCTOBER MEETINGS Oct. 17–19. The 7th Annual Membrane Technology/Planning Conference. Cambridge, MA. Info: BCC, 25 Van Zant St., Norwalk, CT 06855. Oct. 17–19. Biotechnica '89: The 5th International Congress and Exhibition for Biotechnology. Hannover, F.R.G. Info: Hannover Fairs USA, ...
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  • 133
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    Cave-In (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 981-981 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The headline should have read “Supermarket Cave-In Injures Four.” Instead, the newspapers trumpeted “Five Food Chains Refuse Milk of Hormone-Treated Cows” (LA Times), “Grocery Chains Refuse ‘Engineered’ Milk Products” (Washington Post), or “Sour ...
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    URL: http://dx.doi.org/10.1038/nbt1089-981
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  • 134
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    Environmental Release: The Battles and the War on Two Fronts (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 1096-1096 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Deciding how best to regulate the environmental release of genetically engineered organisms has proven to be a thorny—and controversial—issue. Neither the United States nor the European Community (EC) has successfully addressed all the points. We haven't won the war, but in the U.S., at ...
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    Consumers' Need to Digest Information (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 985-985 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Perverse as the notion may seem to those of rational disposition, I have been expecting some reaction against contemporary efforts, on both sides of the Atlantic, to encourage greater understanding of science. The nature of one such reaction is now becoming clear. It emerges, surprisingly, from ...
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    Spider Silk, Symbionts, and Seaweed (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 993-994 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SEATTLE, Wash.—Spider silk may play a major role in tomorrow's high-performance materials, a U.S. Army researcher told conferees at the Society for Industrial Microbiology (SIM) meeting here in August. In its native form, silk from one promising species, the golden orb-weaver (Nephila ...
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    Phage Mu Sheds Nu Light on Topoisomerases (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 995-995 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] COLD SPRING HARBOR, N.Y.—Topoisomerases are essential for DNA replication and recombination; as such, they are the targets for some of the most effective anticancer drugs—such as adriamycin. Speaking at this year's Cold Spring Harbor meeting on bacterial and phage genetics, Martin Pato ...
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    Companies Clash, Collaborate, Consolidate (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 987-990 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Chiron pursues Canadian vaccine maker. In an aggressive move that may foreshadow more biotech consolidation, Chiron (Emeryville, CA) and CIBA-Geigy (Basel, Switzerland) are seeking control of Connaught BioSciences (Toronto, Ontario). Under its charter, the Canadian company—already engaged in ...
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    Approvals Apace, U.S./Japan Firms Ink Links (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 11-12 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Regulatory news is flying fast and furious. The Food and Drug Administration (FDA) has approved Cambridge BioScience's (Boston, MA) five-minute acquired immune deficiency syndrome (AIDS) diagnostic test. Because it does not require laboratory instruments, the test can be administered in remote ...
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    Clinical Advances in Biotechnology (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 996-996 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—A survey of the recent clinical literature supports the impression that biotechnology and pharmaceutical companies have made major gains in developing new drugs. Selected highlights from the journals include the following: • Clinical Advances Using the Colony Stimulating ...
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    Lessons From Wound–Healing Clinical Trials (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 15-16 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW HAVEN, Conn.—Do growth factors really have a potential role in accelerating wound healing? A lot of research scientists, clinicians, and biotech company executives would like to think so. And, in fact, controlled experiments in animal models on burns, incisions, and partial- and ...
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    NIH to Improve Drug Development Efforts (1989)
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    Nature biotechnology 7 (1989), S. 17-17 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—An advisory committee recently urged top officials at the National Institutes of Health (NIH, Bethesda, MD) to improve its rapidly growing AIDS therapeutic drug development program. In particular, the committee recommended that NIH, the Food and Drug Administration (FDA), and ...
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    Biotech to Watch Waste (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 17-17 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—When hypodermic needles and other discarded laboratory materials washed up on beaches last summer, the public outcry pricked Congress into drafting— and quickly approving—the Medical Waste Tracking Act of 1988. The new law directs the Environmental Protection ...
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    New Enzymes the Old–Fashioned Way: Find Them (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 18-18 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] KATATA, Japan—Traditional microbial screening programs continue to be important in the industrial development of novel enzymes as evidenced by presentations at the Taniguchi Foundation's Seventh International Symposium on the Life Sciences (Recent Advances in Applied Enzymology) held here in ...
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    Recombinant Melanin Expressed in Plants (1989)
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    Nature biotechnology 7 (1989), S. 20-20 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—A proprietary gene expression system that acts quickly and temporarily to produce recombinant products in plant tissues—Bio-source Genetics Corp.'s (Vacaville, CA) Geneware®—produces melanin for a “natural” sunscreen. Based on a plant RNA virus vector, the ...
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    Databases: The Cutting Edge (1989)
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    Nature biotechnology 7 (1989), S. 22-23 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] COLUMBUS, Ohio—The explosion in protein and nucleic acid sequencing over the last several years is forcing database managers to choose their strategies wisely. Chemical Abstracts Service (CAS), producer of one of the world's largest bibliographic databases, provided a forum for this topic at ...
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    Conferees Discuss Bioreactors, Separations (1989)
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    Nature biotechnology 7 (1989), S. 28-28 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] SAN FRANCISCO—Few events give as great an appreciation of the biotech universe's diversity as a general industry conference, and Biotech USA, held here last November, was no exception. The three-day event attracted nearly 1,700 scientists, engineers, managers, equipment manufacturers, patent ...
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    Bioblood: Business and Science (1989)
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    Nature biotechnology 7 (1989), S. 28-28 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO—The nation's blood supply has never had to satisfy as many demands as it does today. Not only has the need for transfusable blood increased annually—currently about 16 million units—but that blood also has to be safe to use—a profound scientific challenge. Not ...
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    A Modest Proposal for European Patents (1989)
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    Nature biotechnology 7 (1989), S. 26-26 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—More protection for biological materials, organisms, and the other products and processes of biotechnology More definition Less dispute That's the message the European Commission has sent to the European Community (EC) member countries With an eye to the advent of the “single ...
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    The Carbohydrate Frontier (1989)
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    Nature biotechnology 7 (1989), S. 35-40 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Computer model of the fragment of human immunogammaglobulin, which interacts with specific receptors on the surface of a variety of cells. Oligosaccharide structures (blue, red, and yellow) lie along the outer surface of the protein (green) portion of this glycoprotein. Narasingha Rao, of the Dept. ...
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    Japan Roundup (1989)
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    Nature biotechnology 7 (1989), S. 30-30 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A new source of antibiotics may be the bacteria endogenous to insects. Research scientists at the Agricultural Resources Research Institute (Tsukuba) isolated the first of its kind from brown leaf hopper “flora.” This antibiotic, called andrimid, is effective against the fungus that ...
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    Research Center Brings Enzymes to the Fore (1989)
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    Nature biotechnology 7 (1989), S. 32-32 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] EXETER, U.K.—Chemists at the University of Exeter, together with microbiologists and biochemists at the Universities of Warwick and Kent, have formed an interuniversity Bio-transformations Center. Supported equally by public and private funds, the center will develop the potential of enzymes ...
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    Dynamic Market Emerging for Molecular Modeling (1989)
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    Nature biotechnology 7 (1989), S. 43-47 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Designers of molecular modeling software face even higher hurdles as researchers clamor for more power. No longer content with studying small molecules, the scientific community is setting its sights on large proteins, oligosaccharides, and (perhaps eventually) gigantic complex carbohydrate ...
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    Product Approvals in the Current Environment (1989)
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    Nature biotechnology 7 (1989), S. 48-49 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] As more and more biotechnology products make their way towards the market, companies are accumulating valuable experiences in their dealings with federal regulators. Conversely, the agencies are learning how to adapt their methodologies to account for the differences between biotechnology-derived ...
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    Secretion of Active, Full– and Half–Length Human Secretory Leukocyte Protease Inhibitor by Sacchammyces Cerevisiae (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 55-60 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A cDNA clone for human secretory leukocyte inhibitor (SLPI) was used to construct fusions to the secretion signal sequences of two secreted yeast proteins: invertase and α-factor. The invertase system produced both active SLPI, cleaved at the predicted signal-peptidase processing site, and ...
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    Analyses of Bioreactor Performance by Nuclear Magnetic Resonance Spectroscopy (1989)
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    Nature biotechnology 7 (1989), S. 50-54 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] There are many commercially and scientifically relevant products that must be produced in mammalian cell systems. Growth and maintenance systems (bioreactors) for mammalian cells are not well characterized, however, since these cells are more fastidious and sensitive than are microorganisms. ...
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    A Gene Coding for a Membrane–Bound Hydrolase is Expressed as a Secreted, Soluble Enzyme in Streptomyces Lividans (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 65-68 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A Flavobacterium opd gene, which encodes for a membrane–associated phosphotriesterase, was cloned into Streptomyces lividans strain 66. The gene product was constitutively produced in the streptomycete as a soluble, extracellular enzyme. S. lividans (Gram–positive) was able to use the ...
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    Evaluation of Herbicide Resistance in Transgenic Crops Under Field Conditions (1989)
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    Nature biotechnology 7 (1989), S. 61-64 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have analysed two herbicide resistant transgenic tobacco (Nicotiana tabacum) and four potato (Solanum tuberosum) lines under field conditions. These lines resulted from Agrobacterium mediated transformation of tobacco and potato leaf discs with chimeric bar genes encoding phosphinothricin acetyl ...
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    A Genetic System for Rapidly Assessing Herbicides That Compete for the Quinone Binding Site of Photosynthetic Reaction Centers (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 69-74 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] To facilitate genetic analysis and manipulation of the bacterial photosynthetic apparatus, a new plasmid vector bearing the reaction center and light harvesting structural genes (puf operon) of Rhodobacter capsulatus was constructed. This plasmid (pU2922) can be conjugated from E. coli strains ...
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    Something of Value (1989)
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    Nature biotechnology 7 (1989), S. 7-7 
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    Notes: [Auszug] It had to happen. Sometime over the past month we chanced on the ideal apothegm (known around here as “those pretentious quotes that kick off the First Word”) for this month's column. It was a lofty rumination from some lofty eminence of Wall Street's ...
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    Pure Water for Biotechnology (1989)
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    Nature biotechnology 7 (1989), S. 75-76 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Since purified water is a primary component of injectables, cell culture media, laboratory research reagents, and assays in analytical chemistry, it is important to have a reliable supply on hand. For biotechnology and pharmaceutical applications, the most important objectives in maintaining this ...
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    New Software Products (1989)
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    Nature biotechnology 7 (1989), S. 78-78 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] (See “Dynamic Market Emerging for Molecular Modeling,” this issue, for more about molecular modeling software) The Charmm™ system from Polygen (Waltham, MA) adds to the molecular dynamics simulation functions of the company's Quanta™ molecular modeling software. The ...
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    New Products (1989)
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    Nature biotechnology 7 (1989), S. 79-82 
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    Notes: [Auszug] The Oros Systems (Cambridge, MA) protein A ELISA kit is the first commercial assay for measuring low-level protein A in antibodies purified by solid phase protein A. This sensitive assay works even in the presence of antibodies, helping researchers achieve Food and Drug Administration (FDA) ...
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    Free Literature (1989)
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    Nature biotechnology 7 (1989), S. 83-83 
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    Notes: [Auszug] A Guide to Sample Preparation Using Solid Phase Extraction and Membrane Filtration from Waters (Division of Millipore Corp., Milford, MA) provides product information for liquid and gas chromotography, amino acid, infrared, and ultraviolet sample preparation. The booklet also discusses the ...
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    Water Purification Products (1989)
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    Nature biotechnology 7 (1989), S. 77-77 
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    Notes: [Auszug] The Sartobran® DI membrane filter cartridge for deionized water systems retains particulates down to 0.2 or 0.1 μ. Compatible with hot deionized water and hydrogen peroxide concentrations up to 30 percent, the Sartorius Corp. (Bohemia, Long Island, NY) product uses a polyester prefilter to ...
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    Announcements (1989)
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    Nature biotechnology 7 (1989), S. 84-84 
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    Notes: [Auszug] FEBRUARY MEETINGS Feb. 3–8. Early Embryo Development and Paracrine Relationships. Taos, NM. Info: UCLA Symposia, 103 Molecular Biology Institute, Los Angeles, CA 90024-1378. Feb. 4–11. Human Retroviruses. Tamar-ron, CO. Info: See for Feb. 3–8. Feb. 5–9. Management and ...
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    Skipped Software (1989)
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    Nature biotechnology 7 (1989), S. 85-85 
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    Notes: [Auszug] To the editor: In an article by Pamela Knight entitled “Microcomputer Software Compares 2-D Gels,” (Bio/Technology 6:999, Sept. '88) Bio-Rad's 2-D Analyst II software for comparison of 2-D gels was not mentioned. We would like to point out that this system provides 2-D quantitative ...
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    Fowl Play (1989)
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    Nature biotechnology 7 (1989), S. 85-85 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: I read with interest Jennifer Van Brunt's report “Molecular Farming: Transgenic Animals as Bioreactors” (Bio/Technology 6:1149, Oct. '88) and was quite surprised that she left out our important work on the production of virus-resistant transgenic chickens. (See Salter, ...
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    A Lesson From CD4 (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 85-85 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: Thank you for your column on the HIV CD4 protein “mistake” (Bio/Technology 6:1268, Nov. '88). I have used this example in my elementary genetics class and also forwarded the column to Professor Richard Strohman at Berkeley who teaches a course in “Perspectives in ...
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    Fermentor Omitted (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 85-85 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: As one of the leading manufacturers of fermentation equipment worldwide, we at B. Braun Diessel Biotech GmbH were dismayed at the omission of our products from the chart listing pilot-scale fermentors and bioreactors in the special report on fermentation by Pamela Knight ...
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    Classifying Models (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 85-85 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: We are grateful for the references to our chapter “Biological Modeling” (Computer Control of Fermentation Processes, in press at CRC Uniscience) in Douglas McCormick's article “Play with Purpose: Modeling Biotech Processes” (Bio/Technology 6:887, Aug. '88). ...
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    Ganglioside Technology Patented (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 85-85 
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    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] To the editor: We have read with interest and also concern your article, “New Generation of Liposomes Stay in the Blood,” (Bio/Technology 6:1143, Oct. '88). Dimitri Papahadjopoulos, speaking at the Fourth International Congress of Cell Biology, described experiments he and others ...
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    Biomedicine in the Third World (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 96-96 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have the potential today to improve human well-being on a grand scale—by accelerating the application of biomedical sciences to Third World health problems. But how do we accomplish this? There are two main courses of action, both well-known, yet seriously neglected. One is to combat (if ...
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    Native Microbes' Role in Alaskan Clean-Up (1989)
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    Nature biotechnology 7 (1989), S. 852-852 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—Use of microbes to help clean Exxon's (New York, NY) Alaskan oil spill from last March is surely not one of the most dazzling examples of biotechnology, but it may represent one of the largest operations undertaken to date. In August, following pilot studies conducted by U.S. ...
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    Can Monsanto Pick the Winners? (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 864-864 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Is learning how to splice a gene at Monsanto's Life Sciences Research Center (Chesterfield, MO) a harbinger of ultimate political victory? In May 1987, then Presidential hopeful George Bush tried his hand at it. Looking on were (from left to right) Monsanto's Stephen G. Rogers (research fellow) and ...
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    This Workshop Works (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 871-871 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] What starts off Japanese, emerges half-Canadian, promises to become Latino, and resides in Baltimore? Nova Scotia sushi with summer salsa on a soft roll? An international thriller in which Yokohama detectives join force with Mounties to ferret out South American drug smugglers operating out of the ...
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    The Premarket Review Process for Class III Devices (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 897-902 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] An increasing number of biotechnology products are being reviewed by the Food and Drug Administration (FDA, Bethesda, MD) as Class III medical devices. By definition, Class III devices support or sustain human life, are of substantial importance in preventing impairment of human health, or prevent ...
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    Enkephalins Prouduced in Transgenic Plants Using Modified 2S Seed Storage Proteins (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 929-932 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have explored the possibility of producing large amounts of biologically active peptides as part of chimeric plant seed storage proteins, the 2S albumins. A portion of an Arabidopsis thaliana 2S albumin gene, encoding a region of the protein whose sequence is not highly conserved among different ...
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    Examining Biotech's Global Economic Role (1989)
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    Nature biotechnology 7 (1989), S. 750-750 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—The Congressional Office of Technology Assessment (OTA) recently invited representatives from 15 countries to discuss national efforts in biotechnology and to present their views on biotech's role in a global economy. While all acknowledged the tremendous economic promise of ...
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    U.K. Notice Requirements Proposed (1989)
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    Nature biotechnology 7 (1989), S. 756-756 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] LONDON—A prestigious and influential body, the Royal Commission on Environmental Pollution, has proposed tough new rules for public disclosure of information about planned releases of genetically engineered organisms (GEOs) into the environment. The Commission, which takes a much wider view ...
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    Management Issues Appear More Daunting (1989)
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    Nature biotechnology 7 (1989), S. 756-757 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] WASHINGTON, D.C.—During its second meeting, the National Institutes of Health (NIH, Bethesda, MD) Program Advisory Committee on the Human Genome struggled with several of the formidable management issues facing researchers planning to map and sequence complex genomes (Bio/Technology 7:223, ...
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    Amgen, GI Heading for Patent Showdown (1989)
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    Nature biotechnology 7 (1989), S. 764-764 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] NEW YORK—The battle between Amgen (Thousand Oaks, CA) and Genetics Institute (GI, Cambridge, MA) over patent rights relating to the invention and production of recombinant erythropoietin (EPO) is rapidly coming to a head—on multiple fronts. Trial dates are scheduled in both ...
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    Growth Factors For Wound Healing (1989)
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    Nature biotechnology 7 (1989), S. 793-798 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] The process of wound healing begins immediately following surface lesions or when skin proteins become exposed to radiation, chemical damage or extreme temperatures. Wound repair requires close control of degradative and regenerative processes, involving numerous cell types and complex interactions ...
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    Genome Technology: What Will It All Mean? (1989)
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    Nature biotechnology 7 (1989), S. 639-649 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SANTA MARGHERITA LIGURE, Italy—The impact of the newer genome technologies on our understanding of human genetics was the focus of the European Molecular Biology Organization (Heidelberg, F.R.G.)-International School of Pediatric Sciences (Genoa, Italy) joint workshop held here recently. One ...
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    1989 Compensation Survey (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 875-880 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] At the beginning of July, Bio/Technology sent questionnaires to a cross-section of readers, 671 in the United States and 259 in Europe. We received 304 U.S. responses in time for this report, of which 293 were complete enough to be included in this analysis. Because of postal delays and the added ...
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    Regional Development: The Role and Effectiveness of Governmental Agencies (1989)
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    Nature biotechnology 7 (1989), S. 671-683 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] In the early 1980s, the national mood concerning the commercial potential of biotechnology was decidedly upbeat. Every region of the country saw itself as the hub of a great new industrial machine, rivalling the success of California and Massachusetts in establishing a high-tech identity. As far ...
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    Searle Leaving Its Legacy in the U.K. (1989)
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    Nature biotechnology 7 (1989), S. 547-547 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] OXFORD, U.K.—Three years after being taken over by Monsanto (St. Louis, MO) and closing its biotechnology center at High Wycombe, G. D. Searle has established a new research base in the United Kingdom. The company is donating £2.9 million (just under $5 million) toward the cost ...
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    Generation of Human Embryonic Kidney Cells with Extended In Vitro Life Span through Viral Oncogene Transfection (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 939-946 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Primary cultures of human embryonic kidney (HEK) cells exhibit an in vitro life span of approximately 15 to 20 generations. We report here that transfection of HEK cells with the early gene region of the SV40 DNA tumor virus results in a five-fold increase in cell life span. These cells with ...
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    Protein Patent Problem to Hinder Research? (1989)
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    Nature biotechnology 7 (1989), S. 764-764 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] BERNE, Switzerland—Will the commercial development and patenting of useful pharmacologically active proteins cease, once substantial parts of the human genome have been sequenced? The question was raised by Norman Carey, director of scientific affairs at Celltech (Slough, U.K.), during a ...
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    Japan Roundup (1989)
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    Nature biotechnology 7 (1989), S. 766-766 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Scientists at the Industrial Research Council's Research Institute for Techniques in Industrial Microbiology (Tokyo) have discovered a new biopolymer that can absorb 500 times its own weight in salt water. Its ability to absorb fresh water is even greater—one gram can absorb one liter. Unlike ...
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    Functional Expression of Human Monoclonal Antibody Genes Directed Against Pseudomonal Exotoxin A in Mouse Myeloma Cells (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 805-810 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] We have cloned immunoglobulin (Ig) genes from an Epstein-Barr (EB) virus-transformed human B cell line, FK-001, which produced a monoclonal human IgM that specifically binds Pseudomonas aeruginosa exotoxin A (Ex-A). Cloned Ig genomic DNA was introduced into Ig non-producing mouse myeloma cells, ...
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    USPTO: A Misstep in the Right Direction (1989)
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    Nature biotechnology 7 (1989), S. 762-762 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] ST. LOUIS, Mo.—The U.S. Patent and Trademark Office (PTO) has proposed new rules that most biotech patent applicants submit sequence data on computer disks—following a rigidly defined format. The proposed rules (37 CFR 1.821-825) appeared in the May 16 Official Gazette and the May 2 ...
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    Downstream Processing (1989)
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    Nature biotechnology 7 (1989), S. 777-782 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Downstream processing plays a central role in the commercial success of new protein-based diagnostics and therapeutics. It actually defines the product—typically too complex to pin down to an exact analytical fingerprint—in a precise series of purification steps. Yet for all the ...
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    Expression of Human Anti-Tetanus Toxoid Antibody in Transfected Murine Myeloma Cells (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 799-804 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] Mouse-human heterohybridoma cell line, GF4/1.1, secretes a human anti-tetanus toxoid (anti-TT) antibody of the γ3 isotype. This line was used as a source of mRNA for the construction of cDNA libraries and the subsequent isolation of the sequences encoding the human heavy and light chains. ...
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    Use of Recombinant DNA to Improve Production of Cephalosporin C By Cephalosporium acremonium (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 477-485 
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    Source: Nature Archives 1869 - 2009
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    Notes: [Auszug] A recombinant DNA-modified strain of the filamentous fungus Cephalosporium acremonium, strain LU4-79-6, produced more of the antibiotic cephalosporin C than a non-recombinant strain, strain 394-4, from which it was derived by transformation. Strain 394-4, derived from C. acremonium ATCC 11550 by ...
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    New Products (1989)
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    Nature biotechnology 7 (1989), S. 511-516 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Kontron Electronics (Mountain View, CA) announces the model 700 transient recorder, a modular mainframe-type analog test system. The recorder accepts up to four single- or dual-input expansion modules internally, and up to 56 inputs with external expansion chassis. The recorder's flexible ...
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    Free Literature (1989)
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    Nature biotechnology 7 (1989), S. 519-519 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Enzymes and Research Biochemicals, the 1989/90 catalog from Biozyme Laboratories International (San Diego, CA) lists available bulk quantities of alcohol dehydrogenase, alkaline phos-phatase, glucose oxidase, glutamate dehydrogenase, and peroxidase. Applications in clinical diagnostics and ...
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    New Clues on Folding (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 324-325 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] SAN FRANCISCO—Some experimental model systems are as comfortable and familiar to scientists as old friends. Generations of geneticists and molecular biologists have been raised on bacterial enzymes—such as tryptophan synthase—and bacterial viruses—such as phage f1. What more ...
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    Measuring Contaminating DNA in Bioreactor Derived Monoclonals (1989)
    [s.l.] : Nature Publishing Company
    Nature biotechnology 7 (1989), S. 343-347 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Pharmaceutical manufacturers need to accurately quantity picogram amounts of contaminating DNA in recombinant proteins and monoclonal antibodies intended for therapeutic use. Generally, this requires an assay capable of detecting 10 picograms or less of contaminating DNA per dose of product. ...
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    Immobilization Methods for Piezoelectric Biosensors (1989)
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    Nature biotechnology 7 (1989), S. 349-351 
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    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] Conceptually, biosensors are relatively simple measuring devices that incorporate a biologically active sensing material into a transducer. In practice, researchers continue to search for ideal combinations of biocatalysts—enzymes, antibodies, antigens, bacteria, whole cells, plant slices, ...
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