ALBERT — All Library Books, journals and Electronic Records Telegrafenberg

1

Unbekannt

Genomic islands in pathogenic and environmental microorganisms (2004)

Dobrindt, Ulrich ; Hochhut, Bianca ; Hentschel, Ute ; [weitere]

Nature Publishing Group

In: Nature Reviews Microbiology, 2 (5). pp. 414-424.

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Publikationsdatum: 2020-06-23

Beschreibung: Horizontal gene transfer is an important mechanism for the evolution of microbial genomes. Pathogenicity islands — mobile genetic elements that contribute to rapid changes in virulence potential — are known to have contributed to genome evolution by horizontal gene transfer in many bacterial pathogens. Increasing evidence indicates that equivalent elements in non-pathogenic species — genomic islands — are important in the evolution of these bacteria, influencing traits such as antibiotic resistance, symbiosis and fitness, and adaptation in general. This review discusses the recent lessons that have been learned from pathogenicity islands in pathogenic microorganisms and how they apply to the role of genomic islands in commensal, symbiotic and environmental bacteria.

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2

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Break-up of the Atlantic Deep Western Boundary Current into eddies at 8°S (2004)

Dengler, Marcus ; Schott, Friedrich ; Eden, Carsten ; [weitere]

Nature Publishing Group

In: Nature, 432 . pp. 1018-1020.

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Publikationsdatum: 2017-03-09

Beschreibung: The existence in the ocean of deep western boundary currents, which connect the high-latitude regions where deep water is formed with upwelling regions as part of the global ocean circulation, was postulated more than 40 years ago1. These ocean currents have been found adjacent to the continental slopes of all ocean basins, and have core depths between 1,500 and 4,000 m. In the Atlantic Ocean, the deep western boundary current is estimated to carry (10–40) times 106 m3 s-1 of water2, 3, 4, 5, transporting North Atlantic Deep Water—from the overflow regions between Greenland and Scotland and from the Labrador Sea—into the South Atlantic and the Antarctic circumpolar current. Here we present direct velocity and water mass observations obtained in the period 2000 to 2003, as well as results from a numerical ocean circulation model, showing that the Atlantic deep western boundary current breaks up at 8° S. Southward of this latitude, the transport of North Atlantic Deep Water into the South Atlantic Ocean is accomplished by migrating eddies, rather than by a continuous flow. Our model simulation indicates that the deep western boundary current breaks up into eddies at the present intensity of meridional overturning circulation. For weaker overturning, continuation as a stable, laminar boundary flow seems possible.

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3

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Strong hemispheric coupling of glacial climate through continental freshwater discharge and ocean circulation (2004)

Knutti, R. ; Flueckiger, J. ; Stocker, T. F. ; [weitere]

Nature Publishing Group

In: Nature, 430 . pp. 851-856.

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Publikationsdatum: 2017-03-07

Beschreibung: The climate of the last glacial period was extremely variable, characterized by abrupt warming events in the Northern Hemisphere, accompanied by slower temperature changes in Antarctica and variations of global sea level. It is generally accepted that this millennial-scale climate variability was caused by abrupt changes in the ocean thermohaline circulation. Here we use a coupled ocean–atmosphere–sea ice model to show that freshwater discharge into the North Atlantic Ocean, in addition to a reduction of the thermohaline circulation, has a direct effect on Southern Ocean temperature. The related anomalous oceanic southward heat transport arises from a zonal density gradient in the subtropical North Atlantic caused by a fast wave-adjustment process. We present an extended and quantitative bipolar seesaw concept that explains the timing and amplitude of Greenland and Antarctic temperature changes, the slow changes in Antarctic temperature and its similarity to sea level, as well as a possible time lag of sea level with respect to Antarctic temperature during Marine Isotope Stage 3.

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4

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Iron and phosphorus co-limit nitrogen fixation in the eastern tropical North Atlantic (2004)

Mills, Matthew M. ; Ridame, Celine ; Davey, Margaret ; [weitere]

Nature Publishing Group

In: Nature, 429 . pp. 292-294.

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Publikationsdatum: 2017-03-10

Beschreibung: The role of iron in enhancing phytoplankton productivity in high nutrient, low chlorophyll oceanic regions was demonstrated first through iron-addition bioassay experiments1 and subsequently confirmed by large-scale iron fertilization experiments2. Iron supply has been hypothesized to limit nitrogen fixation and hence oceanic primary productivity on geological timescales3, providing an alternative to phosphorus as the ultimate limiting nutrient4. Oceanographic observations have been interpreted both to confirm and refute this hypothesis5, 6, but direct experimental evidence is lacking7. We conducted experiments to test this hypothesis during the Meteor 55 cruise to the tropical North Atlantic. This region is rich in diazotrophs8 and strongly impacted by Saharan dust input9. Here we show that community primary productivity was nitrogen-limited, and that nitrogen fixation was co-limited by iron and phosphorus. Saharan dust addition stimulated nitrogen fixation, presumably by supplying both iron and phosphorus10, 11. Our results support the hypothesis that aeolian mineral dust deposition promotes nitrogen fixation in the eastern tropical North Atlantic.

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5

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Managing fisheries in a changing climate (2004)

Worm, Boris ; Myers, R. A.

Nature Publishing Group

In: Nature, 429 .

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Publikationsdatum: 2017-03-10

Beschreibung: No need to wait for more information: industrialized fishing is already wiping out stocks.

Materialart: Article , NonPeerReviewed

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6

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Polysaccharide aggregation as a potential sink of marine dissolved organic carbon (2004)

Engel, Anja ; Thoms, S. ; Riebesell, Ulf ; [weitere]

Nature Publishing Group

In: Nature, 428 . pp. 929-932.

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Publikationsdatum: 2019-09-23

Beschreibung: The formation and sinking of biogenic particles mediate vertical mass fluxes and drive elemental cycling in the ocean1. Whereas marine sciences have focused primarily on particle production by phytoplankton growth, particle formation by the assembly of organic macromolecules has almost been neglected2, 3. Here we show, by means of a combined experimental and modelling study, that the formation of polysaccharide particles is an important pathway to convert dissolved into particulate organic carbon during phytoplankton blooms, and can be described in terms of aggregation kinetics. Our findings suggest that aggregation processes in the ocean cascade from the molecular scale up to the size of fast-settling particles, and give new insights into the cycling and export of biogeochemical key elements such as carbon, iron and thorium.

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7

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Effect of trace metal availability on coccolithophorid calcification (2004)

Schulz, Kai ; Zondervan, I. ; Gerringa, L. J. A. ; [weitere]

Nature Publishing Group

In: Nature, 430 . pp. 673-676.

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Publikationsdatum: 2019-09-23

Beschreibung: The deposition of atmospheric dust into the ocean has varied considerably over geological time1, 2. Because some of the trace metals contained in dust are essential plant nutrients which can limit phytoplankton growth in parts of the ocean, it has been suggested that variations in dust supply to the surface ocean might influence primary production3, 4. Whereas the role of trace metal availability in photosynthetic carbon fixation has received considerable attention, its effect on biogenic calcification is virtually unknown. The production of both particulate organic carbon and calcium carbonate (CaCO3) drives the ocean's biological carbon pump. The ratio of particulate organic carbon to CaCO3 export, the so-called rain ratio, is one of the factors determining CO2 sequestration in the deep ocean. Here we investigate the influence of the essential trace metals iron and zinc on the prominent CaCO3-producing microalga Emiliania huxleyi. We show that whereas at low iron concentrations growth and calcification are equally reduced, low zinc concentrations result in a de-coupling of the two processes. Despite the reduced growth rate of zinc-limited cells, CaCO3 production rates per cell remain unaffected, thus leading to highly calcified cells. These results suggest that changes in dust deposition can affect biogenic calcification in oceanic regions characterized by trace metal limitation, with possible consequences for CO2 partitioning between the atmosphere and the ocean.

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8

Digitale Medien

Aneurysms: leukotrienes weaken aorta from the outside (2004)

Palinski, Wulf

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 896-898

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The mechanisms responsible for the formation of arterial aneurysms remain mysterious. Key features include extensive inflammation of the adventitia, the outermost layer of arteries, and dilation of the media, the smooth muscle cell–rich middle layer that conveys mechanical stability and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0904-896

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9

Digitale Medien

When good cholesterol goes bad (2004)

Fogelman, Alan M

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 902-903

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] It has long been accepted that the more HDL cholesterol a person has, the better off he is. However, review of the data from the original Framingham study, which first solidly identified the importance of HDL, or of the data from the placebo group in another large study reveals that many heart ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0904-902

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10

Digitale Medien

Research highlights (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 907-907

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The race is on Efforts to combat the spread of drug-resistant malaria in Africa received a blow this month from research in Science (305, 1124; 2004) that examines the origins of resistance, but hope emerged from another study in Nature (430, 900–904; 2004) that introduces a synthetic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0904-907

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11

Digitale Medien

Methylation-dependent T cell immunity to Mycobacterium tuberculosis heparin-binding hemagglutinin (2004)

Temmerman, Stéphane ; Pethe, Kevin ; Parra, Marcela ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 935-941

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Although post-translational modifications of protein antigens may be important componenets of some B cell epitopes, the determinants of T cell immunity are generally nonmodified peptides. Here we show that methylation of the Mycobacterium tuberculosis heparin-binding hemagglutinin (HBHA) by the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1090

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12

Digitale Medien

New on the market (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1001-1001

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Filter plates Millipore now offers its MultiScreenHTS-PH (phosphocellulose) filter plates for high-throughput kinase screening assays. The 96-well filter plates are automation compatible and follow a prevalidated protocol for high sensitivity, high specificity and reliable kinase assay screening. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0904-1001

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13

Digitale Medien

California dreaming about 'ill-conceived' stem cell plan (2004)

Novak, Kris

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 882-882

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Come November, California might become the first state to fund stem cell research, in direct opposition to the federal government's policy. If voted in, Proposition 71 would allow the state to issue bonds for up to $3 billion over ten years for the research. But given the state's $10 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0904-882b

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14

Digitale Medien

NIH lab shutdown raises concerns about US prion research (2004)

Ready, Tinker

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 884-884

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] When the US National Institutes of Health (NIH) closed a pioneering prion research lab last month, the timing seemed a bit off. British researchers had just identified a second case of variant Creutzfeldt-Jakob disease (vCJD) transmitted through a blood transfusion. The UK Medical Research Council ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0904-884b

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15

Digitale Medien

Laws for the 'beast machine' (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 893-893

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Experimentation on humans has always been problematic, and until World War II, was often prohibited or confined to subjects believed to be subhuman. Most recently, international controversy has focused not so much on research with humans or animals, but on research with human embryos. There is no ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0904-893

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16

Digitale Medien

Role of inducible bronchus associated lymphoid tissue (iBALT) in respiratory immunity (2004)

Moyron-Quiroz, Juan E ; Rangel-Moreno, Javier ; Kusser, Kim ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 927-934

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Bronchus-associated lymphoid tissue (BALT) is occasionally found in the lungs of mice and humans; however, its role in respiratory immunity is unknown. Here we show that mice lacking spleen, lymph nodes and Peyer's patches generate unexpectedly robust primary B- and T-cell responses to influenza, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1091

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17

Digitale Medien

The transcription factor SNAIL represses vitamin D receptor expression and responsiveness in human colon cancer (2004)

Pálmer, Héctor G ; Larriba, María Jesús ; García, José Miguel ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 917-919

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Several non-hypercalcemic analogs of 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) show antitumor activity in a subset of cancer patients. High vitamin D receptor (VDR) expression, which is associated with good prognosis but is lost during tumor progression. We show that the SNAIL transcription ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1095

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18

Digitale Medien

The 5-lipoxygenase pathway promotes pathogenesis of hyperlipidemia-dependent aortic aneurysm (2004)

Zhao, Lei ; Moos, Michael P W ; Gräbner, Rolf ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 966-973

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Activation of the 5-lipoxygenase (5-LO) pathway leads to the biosynthesis of proinflammatory leukotriene lipid mediators. Genetic studies have associated 5-LO and its accessory protein, 5-LO-activating protein, with cardiovascular disease, myocardial infarction and stroke. Here we show that ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1099

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19

Digitale Medien

London calling for British medical research institute (2004)

Spinney, Laura

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 762-762

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] After months of deliberation, a task force set up to consider the future of the National Institute for Medical Research (NIMR)—one of Britain's leading centres for basic medical research—has recommended that the institute be moved from Mill Hill, on the outskirts of London, to a single site in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0804-762b

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20

Digitale Medien

Profile: Irving Weissman (2004)

Novak, Kris

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 766-766

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Irving Weissman is not afraid to wade into the murky waters of stem cell politics. Whether he's in the lab or knee-deep in the Missouri river, he has always had a knack for hooking the big one. Irving Weissman may be most famous for his pioneering research and advocacy on stem cells. But ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0804-766

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21

Digitale Medien

A scientific basis for safety (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 773-773

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The US Food and Drug Administration (FDA) is the granddaddy of government agencies mandated to protect the health of the public. It is respected globally. Polls indicate that most Americans regard its role in assuring safe foods, drugs and medical devices as necessary and positive. Progressive ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0804-773

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22

Digitale Medien

News In Brief (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 765-765

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] US proves unpopular at global AIDS summit For the few US government researchers who gathered in Bangkok for the XV International AIDS Conference, the meeting cannot have been a pleasant experience.... US AIDS coordinator Randall Tobias was often missing from sessions where he was scheduled to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0804-765

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23

Digitale Medien

Injection of recombinant human type VII collagen restores collagen function in dystrophic epidermolysis bullosa (2004)

Woodley, David T ; Keene, Douglas R ; Atha, Tom ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 693-695

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Dystrophic epidermolysis bullosa (DEB) is a family of inherited mechano-bullous disorders that are caused by mutations in the type VII collagen gene and for which ex vivo gene therapy has been considered. To develop a simpler approach for treating DEB, we evaluated the feasibility of protein-based ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1063

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24

Digitale Medien

Type 1 diabetes: focus on prevention (2004)

von Boehmer, Harald

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 783-784

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] During type 1 diabetes, CD4+ and CD8 T+ cells contribute to the destruction of insulin-producing β-cells in the pancreas. Recent studies outline two approaches to combat this destruction. In the June issue of Immunity, Ogasawara et al. show that antibodies blocking NKG2D, a costimulatory ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0804-783

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25

Digitale Medien

Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1 (2004)

Ceradini, Daniel J ; Kulkarni, Anita R ; Callaghan, Matthew J ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 858-864

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The trafficking of circulating stem and progenitor cells to areas of tissue damage is poorly understood. The chemokine stromal cell–derived factor-1 (SDF-1 or CXCL12) mediates homing of stem cells to bone marrow by binding to CXCR4 on circulating cells. SDF-1 and CXCR4 are expressed in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1075

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26

Digitale Medien

Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1 (2004)

Gómez, Marisa I ; Lee, Aram ; Reddy, Bharat ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 842-848

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Staphylococcus aureus is a major human pathogen that is associated with diverse types of local and systemic infection characterized by inflammation dominated by polymorphonuclear leukocytes. Staphylococci frequently cause pneumonia, and these clinical isolates often have increased expression of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1079

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27

Digitale Medien

Mouse model of Noonan syndrome reveals cell type– and gene dosage–dependent effects of Ptpn11 mutation (2004)

Mohi, M Golam ; Ismat, Fraz A ; Bronson, Roderick T ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 849-857

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Noonan syndrome is a common human autosomal dominant birth defect, characterized by short stature, facial abnormalities, heart defects and possibly increased risk of leukemia. Mutations of Ptpn11 (also known as Shp2), which encodes the protein-tyrosine phosphatase Shp2, occur in ∼50% of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1084

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28

Digitale Medien

The sounds of silence (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 653-653

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] On June 2, New York State Attorney General Eliot Spitzer sued GlaxoSmithKline (GSK) for repeated and persistent fraud, contending that the company failed to disclose information on the safety and efficacy of paroxetine for the treatment of depression in children. This lawsuit quickly prompted ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0704-653

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Mexico reverses ban on stem cell research (2004)

Orellana, Claudia

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 656-656

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] After months of controversy, the Mexican parliament has approved the creation of the National Institute of Genomic Medicine. The Senate agreed in late April to eliminate a clause banning the institute from using human embryonic cells or producing human clones for research purposes. “We ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0704-656b

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Reversal of obesity by targeted ablation of adipose tissue (2004)

Kolonin, Mikhail G ; Saha, Pradip K ; Chan, Lawrence ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 625-632

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Obesity is an increasingly prevalent human condition in developed societies. Despite major progress in the understanding of the molecular mechanisms leading to obesity, no safe and effective treatment has yet been found. Here, we report an antiobesity therapy based on targeted induction of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1048

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mTOR inhibition reverses Akt-dependent prostate intraepithelial neoplasia through regulation of apoptotic and HIF-1-dependent pathways (2004)

Majumder, Pradip K ; Febbo, Phillip G ; Bikoff, Rachel ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 594-601

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Loss of PTEN function leads to activation of phosphoinositide 3-kinase (PI3K) signaling and Akt. Clinical trials are now testing whether mammalian target of rapamycin (mTOR) inhibition is useful in treating PTEN-null cancers. Here, we report that mTOR inhibition induced apoptosis of epithelial ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1052

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Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling (2004)

Inoue, Makoto ; Rashid, Md Harunor ; Fujita, Ryousuke ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 712-718

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Lysophosphatidic acid (LPA) is a bioactive lipid with activity in the nervous system mediated by G-protein-coupled receptors. Here, we examined the role of LPA signaling in the development of neuropathic pain by pharmacological and genetic approaches, including the use of mice lacking the LPA1 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1060

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Digitale Medien

Socs3 deficiency in the brain elevates leptin sensitivity and confers resistance to diet-induced obesity (2004)

Mori, Hiroyuki ; Hanada, Reiko ; Hanada, Toshikatsu ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 739-743

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Leptin is an adipocyte-derived hormone that plays a key role in energy homeostasis, yet resistance to leptin is a feature of most cases of obesity in humans and rodents. In vitro analysis suggested that the suppressor of cytokine signaling-3 (Socs3) is a negative-feedback regulator of leptin ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1071

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Look before you leap (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 553-553

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Individualized healthcare, once a seemingly utopian fantasy, is steadily gaining ground as a rational approach to cancer treatment. But recent developments emphasize the need for basic scientific insight as therapies move from the lab to the clinic. In May 2003, the US Food and Drug Administration ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-553

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Biomedical research budget comes up short down under (2004)

Dennis, Carina

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 556-556

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Australian biomedical researchers walked away disappointed from this year's federal government budget, amidst concerns that the nation's biomedical research will struggle to keep pace with the international community. The budget, released on 11 May, forecasts that annual funds for the National ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-556b

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Collaboration may be the cure for what ails drug development (2004)

Erickson, Amy K

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 558-558

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Pharmaceutical companies routinely sink millions of dollars into common diseases, hoping for a multibillion-dollar payoff from the next blockbuster drug. But for orphan diseases with a small market, there are few takers. An emerging model for medical research—exemplified by the Cystic ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-558b

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Reply to “PET concerns in bevacizumab treatment” (2004)

Willett, Christopher G ; Duda, Daniel ; Fischman, Alan ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 561-561

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Willett and Jain reply: The objective of our study was to examine the biological and clinical effects on rectal cancer of an initial bevacizumab infusion, before the initiation of radiation therapy and 5-fluorouracil. Six patients with clinical stage T3 or T4 rectal cancer completed the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-561b

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Selecting the right patient for tumor therapy (2004)

Arteaga, Carlos L

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 577-578

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The epidermal growth factor receptor (EGFR or erbB1) has emerged in recent years as a viable therapeutic target in human cancer. This transmembrane receptor tyrosine kinase is frequently detectable in a wide range of human tumors. However, tumor EGFR levels are not correlated with the level of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-577

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The two-timing thyroid (2004)

Liggett, Stephen B

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 582-583

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Thyroid hormone acts by binding to nuclear receptors to regulate transcription, thereby controlling multiple homeostatic processes, such as metabolic, central nervous system and hemodynamic function. Treatment of hypothyroidism requires weeks of hormone administration to normalize such functions, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-582

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Europe's clinical trial database criticized (2004)

Bosch, Xavier

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 555-555

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The much-disputed European directive on clinical trials went into effect on 1 May (Nat. Med. 9, 1336; 2003), but some experts are warning against the restricted access provided to its new clinical trial database. The database will include general information on a clinical trial, recommendations of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-555b

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Lax security at 'hot' labs draws fire (2004)

Ready, Tinker

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 557-557

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Community groups protesting the proliferation of biodefense 'hot labs' conjure up scenarios of lax security, accidental infections and dangerous microbes escaping into the neighborhood to bolster their case. A previously unreleased report on inspections of existing labs suggests that only luck has ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-557b

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Digitale Medien

China launches new molecular medicine institute (2004)

Mandavilli, Apoorva

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 439-439

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] China is set to launch a new Institute of Molecular Medicine (IMM) in partnership with an existing institute of the same name at the University of California in San Diego. The new institute, to be formally opened in November, will focus initially on translational research in cardiovascular science ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0504-439b

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When are research risks reasonable in relation to anticipated benefits? (2004)

Weijer, Charles ; Miller, Paul B

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 570-573

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The question “When are research risks reasonable in relation to anticipated benefits?” is at the very heart of pressing disputes in the ethics of clinical research. Institutional review boards (IRBs) are criticized for inconsistent decision-making, a phenomenon that may be traced in ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-570

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Digitale Medien

Magic bullets melt fat (2004)

Reitman, Marc L

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 581-582

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Treating obesity is not rocket science—'just' eat less and exercise more. However, in this case common-sense knowledge seems not to be enough, because obesity is becoming more prevalent throughout the world. Obesity is a disease, not a cosmetic feature. It increases the risk of insulin ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-581

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Digitale Medien

Cheating death in the liver (2004)

Guicciardi, M Eugenia ; Gores, Gregory J

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 587-588

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Liver health depends on the efficient removal of unwanted cells, such as aged or virus-infected cells, mainly through apoptosis. In a physiologic setting, new cells generated by mitosis replace those that are eliminated, ensuring organ homeostasis. An alteration in this balance between cell death ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0604-587

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Corrigendum: Differentiating the pathologies of cerebral malaria by postmortem parasite counts (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 435-435

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nat. Med. 10, 143–145 (2004) The name of author Jeffrey S Mueller was spelled ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0404-435c

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Neutralization of CD95 ligand promotes regeneration and functional recovery after spinal cord injury (2004)

Demjen, Deana ; Klussmann, Stefan ; Kleber, Susanne ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 389-395

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The clinical outcome of spinal cord injury (SCI) depends in part on the extent of secondary damage, to which apoptosis contributes. The CD95 and tumor necrosis factor (TNF) ligand/receptor systems play an essential role in various apoptotic mechanisms. To determine the involvement of these ligands ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1007

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Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia (2004)

Ramanathan, Charulatha ; Ghanem, Raja N ; Jia, Ping ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 422-428

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Over 7 million people worldwide die annually from erratic heart rhythms (cardiac arrhythmias), and many more are disabled. Yet there is no imaging modality to identify patients at risk, provide accurate diagnosis and guide therapy. Standard diagnostic techniques such as the electrocardiogram (ECG) ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1011

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Identification of a new human coronavirus (2004)

van der Hoek, Lia ; Pyrc, Krzysztof ; Jebbink, Maarten F ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 368-373

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Three human coronaviruses are known to exist: human coronavirus 229E (HCoV-229E), HCoV-OC43 and severe acute respiratory syndrome (SARS)-associated coronavirus (SARS-CoV). Here we report the identification of a fourth human coronavirus, HCoV-NL63, using a new method of virus discovery. The virus ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1024

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PPARs and the complex journey to obesity (2004)

Evans, Ronald M ; Barish, Grant D ; Wang, Yong-Xu

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 355-361

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Obesity and the related disorders of dyslipidemia and diabetes (components of syndrome X) have become global health epidemics. Over the past decade, the elucidation of key regulators of energy balance and insulin signaling have revolutionized our understanding of fat and sugar metabolism and their ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1025

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Ascorbic acid treatment corrects the phenotype of a mouse model of Charcot-Marie-Tooth disease (2004)

Passage, Edith ; Norreel, Jean Chrétien ; Noack-Fraissignes, Pauline ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 396-401

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Charcot-Marie-Tooth disease (CMT) is the most common hereditary peripheral neuropathy, affecting 1 in 2,500 people. The only treatment currently available is rehabilitation or corrective surgery. The most frequent form of the disease, CMT-1A, involves abnormal myelination of the peripheral nerves. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1023

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New York consortium to build cooperative mouse house (2004)

Brower, Vicki

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 214-214

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In New York City, where space for people is at a premium, finding room for mice is no small task. Faced with cramped quarters for their research animals, six local research institutes—including Columbia University and Rockefeller University—are forming a new consortium to create a ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-214b

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Biologists try to work out bugs in GM insect technology (2004)

Powell, Kendall

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 216-216

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Advances in insect molecular biology have allowed the creation of genetically modified (GM) insects for infectious disease control to step out of the realm of science fiction. But experts say the technology must clear unique scientific and political challenges before it can become a real ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-216a

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News In Brief (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 218-218

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] US budget for 2005 boosts biodefense, food security Biodefense, food security and biosurveillance will receive significant increases in funding under the proposed US budget for 2005. The US Department of Health and Human Services, which oversees the National Institutes of Health (NIH), the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-218

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Man or auto-man? (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 227-228

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Bill McKibben has had enough. He has seen quite enough of the current fruits of the biological revolution to make him very, very worried. And those involved with biotechnology ought take note, because he is raising a worry that is rarely heard in boardrooms and legislative settings where cost and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-227

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Aurora kinases dawn as cancer drug targets (2004)

Sausville, Edward A

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 234-235

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] There are many ways to stop a cell from dividing. Disordered spindle function, for instance, may be a potent signal for apoptosis. Taxanes and vinca alkaloids arrest cell-cycle progression in mitosis by interacting directly with tubulin and interfering with microtubule spindle function. These two ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-234

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AML-1 steps up to the platelets (2004)

Irvin, Brenda J ; Hiebert, Scott W

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 238-239

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Acute myeloid leukemia-1 (AML-1, encoded by the runt-related X1 gene, RUNX1) is perhaps the most frequent target of chromosomal translocations in acute leukemia. The translocations create fusion proteins that repress AML-1-regulated genes. The transcription factor AML-1 is a putative tumor ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-238

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The translation factor eIF-4E promotes tumor formation and cooperates with c-Myc in lymphomagenesis (2004)

Ruggero, Davide ; Montanaro, Lorenzo ; Ma, Li ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 484-486

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The mammalian target of rapamycin, mTOR, regulates cell growth and proliferation. Here we show that the initiation factor of translation (eIF-4E), a downstream effector of mTOR, has oncogenic effects in vivo and cooperates with c-Myc in B-cell lymphomagenesis. We found that c-Myc overrides ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1042

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Reduced atherosclerosis in MyD88-null mice links elevated serum cholesterol levels to activation of innate immunity signaling pathways (2004)

Björkbacka, Harry ; Kunjathoor, Vidya V ; Moore, Kathryn J ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 416-421

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Atherosclerosis, the leading cause of death in developed countries, has been linked to hypercholesterolemia for decades. More recently, atherosclerotic lesion progression has been shown to depend on persistent, chronic inflammation in the artery wall. Although several studies have implicated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1008

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The 'apparent' color of money (2004)

Peritt, David

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 120-120

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor: I read your News Feature, “The color of money” (Nat Med. 9, 1340; 2003), with great interest. I have grappled with this issue for many years and am glad to see it discussed in an open forum. I'm sure such discussions will eventually lead to an appropriate system of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0204-120

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Corrigendum: Fetal and adult human oligodendrocyte progenitor cells effectively myelinate dysmyelinated brain (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 209-209

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nat. Med. 10, 93–97 (2004) The panels in Figure 4a and b should be switched. The panel in Figure 4b should have been labeled 'a', and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0204-209a

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Expression profiling identifies the cytoskeletal organizer ezrin and the developmental homeoprotein Six-1 as key metastatic regulators (2004)

Yu, Yanlin ; Khan, Javed ; Khanna, Chand ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 175-181

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Quelle: Nature Archives 1869 - 2009

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Notizen: [Auszug] Patients presenting with metastatic rhabdomyosarcoma (RMS), the most common soft-tissue sarcoma in children, have a very poor clinical prognosis. This is due, in large part, to our rudimentary knowledge of the molecular events that dictate metastatic potential. We used cDNA microarray analysis of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm966

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Digitale Medien

Nucleus hears axon's pain (2004)

Blesch, Armin ; Tuszynski, Mark H

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 236-237

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Quelle: Nature Archives 1869 - 2009

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Notizen: [Auszug] Successful regeneration after axonal injury hinges on proper communication. Crushing or slicing alerts the axon to send an 'injury signal' to the cell body, which then upregulates expression of a number of regeneration-associated genes, including those encoding growth-associated protein-43, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-236

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Digitale Medien

Research Notes (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 241-241

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Immortal or mortal? It finally happened. Just six years after the creation of the first human embryonic stem cell line and seven years after the cloning of Dolly by nuclear transfer, researchers have generated a human embryonic stem cell line from a donor nucleus. In the 13 February Science, Woo ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0304-241

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Pegylated interferon-α protects type 1 pneumocytes against SARS coronavirus infection in macaques (2004)

Haagmans, Bart L ; Kuiken, Thijs ; Martina, Byron E ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 290-293

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The primary cause of severe acute respiratory syndrome (SARS) is a newly discovered coronavirus. Replication of this SARS coronavirus (SCV) occurs mainly in the lower respiratory tract, and causes diffuse alveolar damage. Lack of understanding of the pathogenesis of SARS has prevented the rational ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1001

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HIV evolution: CTL escape mutation and reversion after transmission (2004)

Leslie, A J ; Pfafferott, K J ; Chetty, P ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 282-289

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Within-patient HIV evolution reflects the strong selection pressure driving viral escape from cytotoxic T-lymphocyte (CTL) recognition. Whether this intrapatient accumulation of escape mutations translates into HIV evolution at the population level has not been evaluated. We studied over 300 ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm992

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AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis (2004)

Ichikawa, Motoshi ; Asai, Takashi ; Saito, Toshiki ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 299-304

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Thema: Biologie , Medizin

Notizen: [Auszug] Embryonic development of multilineage hematopoiesis requires the precisely regulated expression of lineage-specific transcription factors, including AML-1 (encoded by Runx1; also known as CBFA-2 or PEBP-2αB). In vitro studies and findings in human diseases, including leukemias, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm997

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Soldiers battle 'Baghdad boil' (2004)

Lockwood, Deirdre

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 110-110

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] More than 300 US soldiers in Iraq have been diagnosed with the parasitic skin disease leishmaniasis, which is expected to infect nearly 1,000 soldiers by the end of 2004. “This is probably the largest outbreak of leishmaniasis that the US military has ever seen,” says Lt. Col. Peter ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0204-110b

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Antibacterial resistance worldwide: causes, challenges and responses (2004)

Levy, Stuart B ; Marshall, Bonnie

[s.l.] : Nature Publishing Group

Nature medicine 10.2004, 12s, S122-, (8 S.)

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The optimism of the early period of antimicrobial discovery has been tempered by the emergence of bacterial strains with resistance to these therapeutics. Today, clinically important bacteria are characterized not only by single drug resistance but also by multiple antibiotic resistance—the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1145

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Molecular constraints to interspecies transmission of viral pathogens (2004)

Webby, Richard ; Hoffmann, Erich ; Webster, Robert

[s.l.] : Nature Publishing Group

Nature medicine 10.2004, 12s, S77-, (5 S.)

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The successful replication of a viral pathogen in a host is a complex process involving many interactions. These interactions develop from the coevolution of pathogen and host and often lead to a species specificity of the virus that can make interspecies transmissions difficult. Nevertheless, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1151

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Mice lacking calsarcin-1 are sensitized to calcineurin signaling and show accelerated cardiomyopathy in response to pathological biomechanical stress (2004)

Barrientos, Tomasa ; Shelton, John M ; Frank, Derk ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1336-1343

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Signaling by the calcium-dependent phosphatase calcineurin profoundly influences the growth and gene expression of cardiac and skeletal muscle. Calcineurin binds to calsarcins, a family of muscle-specific proteins of the sarcomeric Z-disc, a focal point in the pathogenesis of human ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1132

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Protein microarrays for multiplex analysis of signal transduction pathways (2004)

Chan, Steven M ; Ermann, Joerg ; Su, Leon ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1390-1396

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] We have developed a multiplexed reverse phase protein (RPP) microarray platform for simultaneous monitoring of site-specific phosphorylation of numerous signaling proteins using nanogram amounts of lysates derived from stimulated living cells. We first show the application of RPP microarrays to the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1139

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gp41: HIV's shy protein (2004)

Zwick, Michael B ; Saphire, Erica O ; Burton, Dennis R

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 133-134

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The structure of gp41 was a long-sought and elusive goal for HIV biologists. The difficulties of working with a membrane protein, the strong tendency of gp41 to aggregate, and other hurdles stood in the way. When Chan et al. and Weissenhorn et al. finally produced the first structures in 1997, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0204-133

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UK criticized for embryo screening decision (2004)

Bosch, Xavier

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1266-1266

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The UK's Human Fertilisation and Embryology Authority (HFEA) has come under fire for allowing, for the first time in Britain, genetic screening of embryos for a disease that will not affect the child at birth. Critics say the agency made the ethically charged decision without input from experts, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1204-1266b

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New technologies deliver in treating neurological diseases (2004)

Singer, Emily

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1267-1267

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] New techniques that use RNA interference (RNAi) and osmotic pumps to deliver medicines are moving to clinical trials after proving successful in animal models of amyotrophic lateral sclerosis (ALS). If the methods are successful in humans, researchers say, the results may be applicable to other ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1204-1267a

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Corrigendum: Aberrant cannabinoid signaling impairs oviductal transport of embryos (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1397-1397

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nat. Med. 10, 1074–1080 (2004). In the online version of this article, the right axis of the graph in Figure 1a was missing its label. It should be labeled 'average litter size.' Also in the online version, the link for Figure 2 was incorrect. This has now been ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1204-1397b

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Can nicotine treat sepsis? (2004)

Matthay, Michael A ; Ware, Lorraine B

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1161-1162

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Sepsis affects approximately 750,000 people and accounts for over 200,000 deaths each year in the United States alone. Despite treatment with appropriate antibiotics, patients with sepsis often develop multiple organ failure, including shock, resulting from an overwhelming inflammatory response. ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1104-1161

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78

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Transplantation tolerance: babies take the first step (2004)

Obhrai, Jagdeep S ; Lakkis, Fadi G

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1165-1166

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Transplantation immunobiology for the past half century has been shaped by the pursuit of tolerance—acceptance of a foreign graft as self while maintaining responsiveness to other antigens. In 1953, Billingham, Brent and Medawar conceptualized transplantation tolerance and proved it is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1104-1165

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Corrigendum: 4-1BB-mediated immunotherapy of rheumatoid arthritis (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1261-1261

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Thema: Biologie , Medizin

Notizen: [Auszug] Nat. Med. 10, 1088–1094 In the Figure 4 legend, “CD11c+CD8+ T or CD11c−CD8+” should read “CD11c+CD8+ or CD11c−CD8+ T cells.” In b of the Figure 5 legend, “control IgG or” should be ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1104-1261

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New on the market (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1262-1262

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] In a spin Beckman Coulter introduces the Allegra X-15R benchtop centrifuge, providing fast separations and optimal recovery in the large capacity 4 × 750-ml rotor. This new instrument spins the popular rotor at 5,250 g and also spins microplate carriers. Suitable for many applications, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1104-1262

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Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis (2004)

Wang, Tian ; Town, Terrence ; Alexopoulou, Lena ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1366-1373

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] West Nile virus (WNV), a mosquito-borne single-stranded (ss)RNA flavivirus, causes human disease of variable severity. We investigated the involvement of Toll-like receptor (Tlr) 3, which recognizes viral double-stranded (ds)RNA, on WNV infection. Tlr3-deficient (Tlr3−/−) mice were more ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1140

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Plus ça change, (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1263-1263

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Plus c'est la même chose. The more things change, the more they stay the same. In the wake of the 2 November presidential election in the US, we hope that the inverse of the saying will prove true. If the scientific enterprise in the US is to maintain its integrity and pre-eminence, change is ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1204-1263

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Despite snags and skepticism, Thai vaccine trial lumbers on (2004)

Padma, T. V.

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1267-1267

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The US Food and Drug Administration (FDA) may not license for use in the US an AIDS vaccine now in large-scale trials in Thailand because it has “a relatively low level of efficacy,” the agency says. But despite controversy surrounding the vaccine, the FDA continues to support the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1204-1267b

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Immune response to SARS sets up puzzling paradox (2004)

Mandavilli, Apoorva

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1268-1268

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Severe acute respiratory syndrome (SARS) rarely makes headlines these days, but immunologists are still chasing down why only a subset of people became severely ill and died from the disease. Popular hypotheses all suggest that an overactive or otherwise dysfunctional immune response may be to ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1204-1268a

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Aggressive amyloidosis in mice expressing human amyloid peptides with the Arctic mutation (2004)

Cheng, Irene H ; Palop, Jorge J ; Esposito, Luke A ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1190-1192

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] The Arctic mutation within the amyloid-β (Aβ) peptide causes Alzheimer disease. In vitro, Arctic-mutant Aβ forms (proto)fibrils more effectively than wild-type Aβ. We generated transgenic mouse lines expressing Arctic-mutant human amyloid precursor proteins (hAPP). Amyloid ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1123

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News Feature: Mood Swings (2004)

Mandavilli, Apoorva

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1010-1012

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Thema: Biologie , Medizin

Notizen: [Auszug] In 1988, Julio Licinio was finishing his residency in psychiatry at the New York Hospital-Cornell Medical Center. In those days, the mainstay of treatment for patients with depression was a class of drugs called tricyclics. The drugs caused serious side effects and carried the risk of a fatal ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1010

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87

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Transgenic mouse model for monitoring endoplasmic reticulum stress in vivo (2004)

Iwawaki, Takao ; Kohno, Kenji ; Miura, Masayuki

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1014-1014

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Miura replies: We developed the endoplasmic reticulum stress-activated indicator (ERAI) system for monitoring endoplasmic reticulum (ER) stress in vivo. The system is based on the selective splicing of XBP1 mRNA by IRE1 during ER stress. We confirmed that XBP1 mRNA splicing occurs in several mouse ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1014

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Explorations in the land of DNA and beyond (2004)

Meselson, Matthew

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1034-1037

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Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Like many of my colleagues, I have liked science for as long as I can remember. Though not college educated, my parents were always encouraging, as were two uncles who knew a little chemistry. When I was still in grammar school, the basement of our house in Los Angeles became a sizeable laboratory ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1034

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89

Digitale Medien

Hematopoietic stem cells get closer to the bone (2004)

Eaves, Connie

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1042-1044

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Hematopoietic stem cells (HSCs) are rare cells that persist throughout adult life in the bone marrow. Some of these cells continuously detach from their 'niche' at the surface of the bone to enter the blood, from which they then colonize other sites. The enormous regenerative potential of HSCs, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1042

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90

Digitale Medien

Nutrient sensor links obesity with diabetes risk (2004)

Patti, Mary-Elizabeth ; Kahn, Barbara B

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1049-1050

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Obesity is a growing threat worldwide, with more than 300 million obese adults. Despite major advances in unraveling the complex networks regulating food intake and energy balance, our understanding of how obesity causes insulin resistance, diabetes, cardiovascular disease and other components of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1049

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91

Digitale Medien

Corrigendum: CDC91L1 (PIG-U) is a newly discovered oncogene in human bladder cancer (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1139-1139

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Nat. Med. 10, 374–381 (2004) The formula cited in the Methods to calculate expression level and DNA copy number from real-time PCR is incorrect. The correct formula that was used is: 10 × 2−(cycle number of target gene − cycle number of ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1139b

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92

Digitale Medien

Vascular endothelial growth factor (VEGF) induces remodeling and enhances T H 2-mediated sensitization and inflammation in the lung (2004)

Lee, Chun Geun ; Link, Holger ; Baluk, Peter ; [weitere]

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1095-1103

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Exaggerated levels of VEGF (vascular endothelial growth factor) are present in persons with asthma, but the role(s) of VEGF in normal and asthmatic lungs has not been defined. We generated lung-targeted VEGF165 transgenic mice and evaluated the role of VEGF in T-helper type 2 cell (TH2)-mediated ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1105

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93

Digitale Medien

Foreword: Towering science: an ounce of creativity is worth a ton of impact (2004)

Goldstein, Joseph L

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1015-1017

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Here is a mind-boggling statistic. For every minute you spend reading this article, one new article will enter the world's biomedical literature. Last year, 500,000 new articles were published in more than 4,000 journals archived by the National Library of Medicine's MEDLINE Database. Even if only ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1015

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94

Digitale Medien

How I became one of the fathers of a superfamily (2004)

Chambon, Pierre

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1027-1031

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Elucidating the mechanisms underlying transcriptional control in vertebrates has been my main research project for almost 45 years. It originated from my M.D. thesis work (1958) on the effects of X-ray irradiation on free ribonucleotides in rat tissues, which suggested that RNA could be synthesized ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1027

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95

Digitale Medien

Biography of a cytologist (2004)

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1040-1040

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Cyril Darlington was the leading cytologist in Britain between 1930 and 1950, and a major figure in the British genetics community, as well-known for his cantankerous personality as for his science. The title of this biography is misleading; Darlington did not invent, or even discover, the ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1040

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96

Digitale Medien

Bone marrow spawns brain killers (2004)

Iadecola, Costantino

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1044-1045

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Ischemic stroke is a devastating brain disease that afflicts millions worldwide. It is caused by a sudden occlusion of a cerebral artery that cuts off the blood supply to a restricted region of the brain. The loss of cerebral blood flow, or cerebral ischemia, leads to permanent brain damage and ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1004-1044

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97

Digitale Medien

Properties of a disease-specific prion probe (2004)

Deslys, Jean-Philippe ; Gorochov, Guy

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 11-11

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] To the editor: In a recently published article, Paramithiotis et al. describe antibodies specific for the prion Tyr-Tyr-Arg (YYR) repeat motif. These antibodies interact with the pathological isoform of the prion protein (PrPSc), but not with the normal cellular isoform (PrPC). Because of this ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0104-11a

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98

Digitale Medien

Modeling the emergence of the 'hot zones': tuberculosis and the amplification dynamics of drug resistance (2004)

Chou, Tom ; Blower, Sally M

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 1111-1116

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] 'Hot zones' are areas that have 〉5% prevalence (or incidence) of multidrug-resistant tuberculosis (MDRTB). We present a new mathematical model (the amplifier model) that tracks the emergence and evolution of multiple (pre-MDR, MDR and post-MDR) strains of drug-resistant Mycobacterium ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm1102

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99

Digitale Medien

China's new AIDS policy faces great wall of skepticism (2004)

Chou, I-han

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 4-4

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] China has finally announced its decision to act on its impending AIDS crisis, but experts say its strategy is in many ways premature and poorly planned.... Official estimates place the number of HIV-positive people in China at 840,000, which is relatively low for a population of 1.2 billion. Most ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0104-4a

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100

Digitale Medien

Legal battle threatens universities' use of patented technologies (2004)

Ready, Tinker

[s.l.] : Nature Publishing Group

Nature medicine 10 (2004), S. 5-5

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ISSN: 1546-170X

Quelle: Nature Archives 1869 - 2009

Thema: Biologie , Medizin

Notizen: [Auszug] Duke University researchers have been asked to review their use of patented research technologies and use alternative approaches wherever possible. An ongoing legal battle between the university and a former researcher could trigger similar reviews at other institutions. For more than 100 years, ...

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1038/nm0104-5a

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