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  • Q1-390  (1.076)
  • thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences  (594)
  • thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology  (195)
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  • 1
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: As a member of the protein family known as neurotrophins, brain-derived neurotrophic factor (BDNF) plays a crucial role in supporting healthy brain function, which includes synaptic plasticity, cellular differentiation, learning, and the survival of nerve cells. Neuronal plasticity refers to the nervous system’s ability to adapt and respond to environmental conditions, involving various structural and functional mechanisms that can lead to changes in neural circuits, the formation of new synapses, and the generation of fresh neurons. BDNF has emerged as a significant regulator of neuronal plasticity. It is worth noting that the pathophysiological processes underlying central nervous system disorders and neuropsychiatric conditions such as depression, anxiety, autism, and schizophrenia, as well as neurodegenerative diseases like Parkinson’s and Alzheimer’s, are influenced by BDNF. Due to its robust neuroprotective properties and recently discovered anti-inflammatory and anti-apoptotic characteristics, BDNF has long been considered a potential candidate for preventing neurodegeneration. In the context of autism spectrum disorder, BDNF holds great promise as a central focus for therapeutic efforts. Its significance extends to the field of spinal cord injury, where it assumes a multifaceted role in the intricate pathophysiological processes at play. BDNF functions as a catalyst for the growth of axons, a crucial step in the restoration of the nervous system following damage. In the context of sepsis, research into the potential of BDNF’s anti-inflammatory properties to mitigate organ damage is quite noteworthy. Additionally, current findings suggest that combining exercise with vitamin D may offer a promising approach to increase BDNF levels and improve brain health. This book presents comprehensive information on BDNF and its role in promoting neuroprotection. The chapters offer insights into recent developments, molecular principles, and innovative therapeutic approaches for neurodegenerative disorders and brain health.
    Schlagwort(e): bdnf ; inflammation ; oxidative stress ; biomarker ; sepsis ; ketamine ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 2
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Statins are now the most widely used agents in patients with dyslipidemia, atherosclerosis and cardiovascular disease. However, their effects and mechanisms have not been fully investigated, and research continues to reveal new aspects of statins. The up-to-date content of this book will be useful to physicians in cardiovascular disease and geriatrics, and to academics conducting research on statins. It includes novel perspectives leading to new insights and advancing existing knowledge on statins.
    Schlagwort(e): Statins ; LDL-C ; HDL-C ; ASCVD ; PCSK9 Inhibitors ; NPC1L1 Inhibitor ; ACLY Inhibitors ; Endothelial Cell ; Inflammation ; Liver Injury ; Muscle Symptoms ; New-Onset Diabetes ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 3
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: The nervous system is an essential component of the human body and is divided into two main systems: the central nervous system (CNS) and the peripheral nervous system (PNS). The CNS is composed of the brain and the spinal cord and acts as the command center of the organism. The PNS is a network of nerves that extends from the spinal cord throughout the body and regulates both voluntary and involuntary movements, such as digestion, heart rate, breathing, and body temperature. Within the PNS, there are two subdivisions: the somatic nervous system and the autonomic nervous system. The somatic system controls voluntary movements, while the autonomic system operates automatically and regulates essential involuntary functions like heart rate and digestion. It is further divided into two branches, the sympathetic and parasympathetic systems, which work together to maintain homeostasis. Alterations in the autonomic nervous system can lead to various diseases, as these two branches play a crucial role in regulating the organs and systems of the body. For example, an imbalance in the sympathetic system can result in excessive heart rate and blood pressure, while a dysfunction in the parasympathetic system can lead to digestive problems. Therefore, understanding its divisions and functions is essential for the diagnosis and treatment of diseases caused by autonomic nervous system dysfunction. This book provides a comprehensive overview of this system and its functions.
    Schlagwort(e): physiology ; pain ; cancer ; diabetes mellitus ; melatonin ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 4
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Acetylcholine - Recent Advances and New Perspectives describes research related to the neurotransmitter acetylcholine. Acetylcholine was discovered as a neurotransmitter about 100 years ago. Still, researchers around the world study this important signaling molecule in terms of its chemistry, biochemistry, function in the central and peripheral nervous system, and relevance for neurological disorders and diseases. This book focuses on the role of acetylcholine in individual nerve cells, neural circuits, and specific brain regions. In addition, the book illustrates acetylcholine from historical perspectives to technological advances, as well as the use of novel tools in health and disease, in various animal models and organisms. As an added benefit, chapters in the book describe acetylcholine in its relation to paraoxonase enzymes, acetylcholine esterase, neurotoxins, and organophosphorus compounds. Furthermore, this book provides an overview of the work that is being done on acetylcholine and highlights any gaps and areas that would benefit from further exploration. It is a useful resource for students and researchers in biological, chemical, medical, and history disciplines.
    Schlagwort(e): alzheimer’s disease ; neuroinflammation ; chronic diseases ; nervous system ; prefrontal cortex ; homology modeling ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 5
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: • Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations • Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies • Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.
    Schlagwort(e): thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 6
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed in animals, as studies attempt to identify and quantify metabolites, and later in humans, with care to further characterize metabolites that are either unique to or produced disproportionately in humans compared to animals. Characterization includes the determination of enzyme systems or other biological mechanisms that produce each identified metabolite; this information is used to predict potential drug-drug interactions with other compounds that increase or decrease metabolite formation and sources of biological variability in response or toxicity with varying patient genetics, which affect CYP isoform expression. This book’s purpose is to provide some understanding of the biology and current technology applied in the field of drug metabolism.
    Schlagwort(e): diabetes, drug discovery, phytochemicals, natural products, pharmacogenetics, biotransformation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 7
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: The autonomic nervous system is one of the most important involuntary control mechanisms that primarily controls and modulates the functions of the visceral organs. The book discusses some of the specificities of the autonomic nervous system in terms of dendritic development in the sympathetic compartment, as well as a detailed description of noradrenergic groups and their key role in the modulation of all antinociceptive and autonomic responses elicited by painful or threatening situations. In the book, only those cases are mentioned that are closely related to disorders or changes of function of the autonomic nervous system. This book can evoke interest in many researchers who want to use the information for the advancement of their research towards a better understanding of the autonomic regulatory mechanisms.
    Schlagwort(e): inflammation, sepsis, heart rate variability, analgesia, ischemia, arrhythmias ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 8
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: COVID-19 is a rampant worldwide problem. It is caused by the SARS-CoV-2 virus and is manifest in different variants. The Delta variant compromised existing therapeutic and preventive options for this disease and is beginning to be replaced by the Omicron variant. Through pharmaceutical biotechnology, three different treatment approaches to COVID-19 have been developed: computer-aided drug design (CADD); rational drug design in the wet lab; and the advanced drug delivery system. These approaches are heavily influenced by advances in life sciences, such as the development of structural bioinformatics, the establishment of nanobiotechnology as a standard approach in drug design, and major advances in structural biology such as the development of the CryoEM method. This book will focus on providing possible solutions to the ongoing COVID-19 pandemic in light of these advances in life sciences.
    Schlagwort(e): Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 9
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Serotonin - A Chemical Messenger Between All Types of Living Cells is a very interesting book on the most ancient neurotransmitter, hormone and trophic factor serotonin or 5-hydroxytryptamine (5-HT). This unique chemical is present in all living cells including plants and animals. This book will take us through a serene journey of the evolutionary history of serotonin and its role from man to mollusk. There are many interesting chapters incorporated in this book, including novel approaches for detecting minor metabolites of serotonin in human plasma, production and function of serotonin in cardiac cells, immuno-thrombotic effects of serotonin in platelets to the identification and localization of serotonin in the nervous system and gonad of bivalve mollusks.
    Schlagwort(e): oocyte, sperm, nervous system, inflammation, biomarkers, obesity ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 10
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Huntington's Disease is one of the well-studied neurodegenerative conditions, a quite devastating and currently incurable one. It is a brain disorder that causes certain types of neurons to become damaged, causing various parts of the brain to deteriorate and lose their function. This results in uncontrolled movements, loss of intellectual capabilities and behavioural disturbances. Since the identification of the causative mutation, there have been many significant developments in understanding the cellular and molecular perturbations. This book, "Huntington's Disease - Core Concepts and Current Advances", was prepared to serve as a source of up-to-date information on a wide range of issues involved in Huntington's Disease. It will help the clinicians, health care providers, researchers, graduate students and life science readers to increase their understanding of the clinical correlates, genetic aspects, neuropathological findings, cellular and molecular events and potential therapeutic interventions involved in HD. The book not only serves reviewed fundamental information on the disease but also presents original research in several disciplines, which collectively provide comprehensive description of the key issues in the area.
    Schlagwort(e): Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 11
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book intends to strike a balance between developments in research and the fact that researchers must absorb and link to scientific advances with clinical practice so that the management of diseases can be based on sound physiological concepts. This book addresses several controversial issues regarding a natural molecule with fascinating pharmacological and therapeutic effects. The book contains three sections: Section 1: Pharmacology and Therapeutic Applications of Resveratrol; Section 2: Bioavailability, Metabolism, and Mode of Action of Resveratrol; Section 3: Resveratrol and Its Role in Chronic and Degenerative Diseases. Does it Add Life to Years or Years to Life? It is our hope that this book will motivate readers to approach the evidence on the use resveratrol and thereby spark an interest in making further contributions to the current scientific debate and treatment development efforts.
    Schlagwort(e): antioxidant, aging, inflammation, oxidative stress, diabetes, autophagy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 12
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book discusses various topics in pharmacovigilance. The first section addresses such topics as approaches to minimize adverse drug reactions, different stakeholders and their importance in pharmaceutical policy development, changing needs for pharmacovigilance in the African region, machine learning applications in pharmacovigilance, and pharmacovigilance of biological drugs. The second section discusses signal detection, which is a promising approach that helps in the early identification of new, rare drug reactions (desired or undesired).
    Schlagwort(e): machine learning ; data mining ; elderly ; biosimilar ; supervised learning ; mental disorders ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 13
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: The book "Drug Discovery - Concepts to Market" is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the latest drug discovery trends that have been revolutionized with up-to-date technological developments. This book comprises single chapters authored by various researchers and edited by an expert active in the drug development research area. All chapters are independently complete but united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts in this field from international authors and open new possible research paths for further novel developments.
    Schlagwort(e): obesity, apoptosis, metabolism, antimicrobial, mass spectrometry, antibiotics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 14
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Circadian clocks are endogenous and temperature-compensating timekeepers that provide temporal organization of biological processes in living organisms. Circadian rhythms allow living organisms to adapt to the daily light cycles associated with Earth's rotation and to anticipate and prepare for precise and regular environmental changes. This book discusses the fundamental advances of how the circadian clock regulates critical biological functions as well as the cellular and molecular mechanisms controlling circadian rhythm in living organisms. It also provides new insights into and sheds new light on the current research trends and future research directions related to circadian rhythm. This book provokes interest in many readers, researchers and scientists, who can find this information useful for the advancement of their research works towards a better understanding of circadian rhythm regulatory mechanisms.
    Schlagwort(e): melatonin, chronobiology, circadian rhythms, stroke, cardiomyopathy, chagas disease ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 15
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Antibiotic resistance is a global health crisis. Misuse of antibiotics in humans, animals, food, and agriculture has compounded the situation. Bacterial infections have returned decades after medicines were first used. This book discusses antibiotic resistance and some of the organisms that pose immediate, serious, and alarming dangers. It highlights the need for a broader, more comprehensive approach to fighting bacterial infections, which may involve non-compound techniques (other than standard antibacterial drugs) that target bacteria or the host, such as antibodies, probiotics, phytobiotics, and vaccinations.
    Schlagwort(e): Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 16
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book brings together recent developments in the field of drug delivery. Technological advancements in the field of pharmaceutical sciences have revolutionized the patient care industry. The book serves to bridge the gap between the current research scenario and the technical knowledge provided at the pharmaceutical institutions to maximize the skills of individuals involved at any level in this domain. Chapters address topics related to the formulation and evaluation of drug delivery systems, various targeting approaches and novel tools, and design and statistical techniques employed to develop robust and effective dosage forms.
    Schlagwort(e): Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 17
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Proprioception is the sense of body position and movement, with conscious and unconscious components, that determines and conditions the human body’s relationship with the environment. This quality of mechanosensitivity deteriorates in some pathologies and is responsible for some alterations of the locomotor system that appear in elderly persons. In those situations, the failure of proprioception reduces the quality of life of the subjects. The widespread use in developed countries of substitute joint prostheses makes it necessary to rethink the concepts of movement detection and perception. As such, this book examines the basics of proprioception as well as its function in the lower extremities, the head, in children with disabilities, and its connection with virtual reality.
    Schlagwort(e): virtual reality, neuroplasticity, ion channels, neurology, electromyography, orthopedics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 18
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 19
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 20
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: The autonomic nervous system (ANS) is a subsystem of the nervous system that possesses several levels (groups) for receiving, transmitting, generating, and processing information. This book presents a comprehensive overview of the ANS, including chapters on the role of the ANS in a healthy lifestyle, the ANS–stress relationship, general anesthesia and the ANS, signaling pathways, and more.
    Schlagwort(e): Biology, life sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 21
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Scientific interest in cannabinoid research is currently experiencing a significant increase because of changing attitudes toward Cannabis and the evolving awareness of its pharmaceutical benefits. Coincidently, numerous jurisdictions are moving toward legalizing Cannabis and Cannabis-derived products, which reflects a larger global movement to understand Cannabis and its bioactive chemicals for their potential biomedical uses, harms, and economic value. Research activities are surging to fill important knowledge gaps in the field of cannabinoids as they continue to be identified. The purpose of this book is to summarize some leading areas of research in the cannabinoid field where knowledge gaps are actively being addressed. The research described herein spans basic biological and clinical research.
    Schlagwort(e): epilepsy, pain, addiction, terpenes, cannabinoids, cannabis ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 22
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Pharmacognosy is a term derived from the Greek words for drug (pharmakon) and knowledge (gnosis). It is a field of study within Chemistry focused on natural products isolated from different sources and their biological activities. Research on natural products began more than a hundred years ago and has continued up to now with a plethora of research groups discovering new ideas and novel active constituents. This book compiles the latest research in the field and will be of interest to scientists, researchers, and students.
    Schlagwort(e): cancer, antioxidant, drug discovery, secondary metabolites, polyphenols, traditional medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 23
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: The book "Cognitive and Computational Neuroscience - Principles, Algorithms and Applications" will answer the following question and statements: System-level neural modeling: what and why? We know a lot about the brain! Need to integrate data: molecular/cellular/system levels. Complexity: need to abstract away higher-order principles. Models are tools to develop explicit theories, constrained by multiple levels (neural and behavioral). Key: models (should) make novel testable predictions on both neural and behavioral levels. Models are useful tools for guiding experiments. The hope is that the information provided in this book will trigger new researches that will help to connect basic neuroscience to clinical medicine.
    Schlagwort(e): surveillance, inverse model, reverse engineering, behavior, forward model ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 24
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: With the increasing emergence of viral infections worldwide, researchers are working to develop new and non-conventional treatments for infectious diseases. This is particularly true for SARS-CoV-2, which initiated a pandemic in 2019. With a focus on coronavirus, this book provides an overview of antiviral agents and new approaches to drug design. It includes five chapters that address new avenues for drug discovery, reprofiling of current drugs, computer-aided drug design, and more.
    Schlagwort(e): Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 25
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Drug authentication is generally governed by critical procedures. This book presents a comprehensive overview of drug design, highlighting the steps involved from the discovery phase to product approval. Chapters address such topics as drug development processes, pharmaceutical nanoformulations and cosmeceuticals for topical use, ocular drug delivery systems, and drug development involving computer-aided drug design, machine learning, and artificial intelligence.
    Schlagwort(e): Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 26
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: In the present volume, we collected state-of-the-art chapters on diagnosis, treatment, and social implications. The first section describes diagnostic processes. It describes a reevaluation of projective techniques, a new clinical tool in psychotraumatology, the foundations of the framing technique, and an overview on integrative approaches. The second section focuses on new developments in the field with special emphasis on culture-specific contexts. From parenting of adolescents in India to the influence of poverty on mental health issues in Mexico, as well as the use of marijuana and Internet addiction, some of the most important fields are highlighted. The third section concentrates on therapy. It shows how to react to bullying and reviews the use of antidepressants in children and adolescents.
    Schlagwort(e): adolescents, epidemiology, trauma, poverty, earthquake, mindfulness ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 27
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    Publikationsdatum: 2024-04-01
    Beschreibung: The area covered by this book undoubtedly includes a multidisciplinary approach. It combines and uses the wide range of methods and knowledge from a variety of disciplines in chemistry, pharmacology, and biology to synthesize new or extracted natural substances and their characterization, in terms of bioefficiency in different systems, pharmacokinetics, and pharmacodynamics. Importance is placed on revealing the interactions and effects on organisms. The process is long term, ranging from synthesis to potential testing of substances in animal studies, followed by monitoring effects on patients. The purpose is to define molecular targets of the highest efficacy of the prepared drugs, minimizing the undesirable effects. The content of this book is conceived with these intentions.
    Schlagwort(e): apoptosis, pharmacokinetics, medicinal plants, toxicity, antimicrobial resistance, cytotoxicity ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 28
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: This book collects the contribution of a selected number of clinical psychiatrists, interested in the clinical application of some aspects of neurobiology of anxiety. The seven chapters of the book address some issues related to the latest acquisitions of neurobiology, in particular those aspects that are related to responses to treatment - both psychological and pharmacological. Some chapters are also dedicated to the comorbidities, a rule rather than an exception when it comes to anxiety. Each author summarized the clinical importance of his work, underlining the clinical pitfalls of this new book on anxiety.
    Schlagwort(e): comorbidity, genetics, pharmacology, social media, gaba, psychotherapy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 29
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    Publikationsdatum: 2024-04-01
    Beschreibung: As teachers of parasite biology, we are becoming increasingly aware of the lack of detailed information and experimental approaches about drugs and drug resistance in many medical schools and undergraduate courses. Therefore, this book discusses parasite biology, antimalarial drugs and their mechanism of action, and the dynamic situation of evolving drug resistance of parasites, which has become a pressing issue. It provides insight into the plasmodium species, the role of cytokines in activating immune response during malaria infection, the importance of antimalarials as a therapeutic option, issues of drug resistance and co-resistance, and validation of evolved resistance in humanized mouse models. It is a timely addition to the existing literature on malaria parasite biology and a useful resource for students, researchers, and those working in the field of parasite biology, drugs, drug resistance of infectious diseases in general, and human malaria parasites in particular and beyond.
    Schlagwort(e): malaria, plasmodium falciparum, artemisinin, antimalarial drugs, machine learning, immunotherapy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 30
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Botulinum Toxin - Recent Topics and Applications provides doctors and researchers with the most up-to-date information on the structure and action of botulinum toxins as well as their usage to treat a wide range of disorders. The book covers the fundamentals of botulinum toxins, including improvements in our understanding of their molecular structure and mechanism of action. Furthermore, it covers the production and formulation of botulinum toxins for clinical applications. The information contained herein will hopefully shift the paradigm of botulinum toxin research, moving it away from a focus on toxin attributes toward a focus on toxin engineering based on patient requests and physician experiences in everyday practice.
    Schlagwort(e): Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 31
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Corticosteroids have a broad spectrum of mechanisms making them useful for treating a variety of pathological entities. They are crucial drugs in clinical control in a plethora of patients, despite recent advances resulting from the availability of new molecules with great selectivity for different receptors, cells, or biological mediators. This book includes high-quality scientific reviews of corticosteroids and their numerous uses.
    Schlagwort(e): glucocorticoids, immune system, adverse effects, brain tumor, cochlear implant, meniere’s disease ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
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  • 32
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    Publikationsdatum: 2024-04-05
    Beschreibung: Nerve cells form thousands of contact points, the synapses, to communicate information with other neurons and target cells. Synapses are sites for changes in brain function through modification of synaptic transmission termed synaptic plasticity. The study of synaptic plasticity has flourished over the years with the advancement of technical breakthroughs and is a timely scientific endeavor today just like it was several decades ago. This book contributes to our understanding of synaptic plasticity at the molecular, biochemical, and cellular systems and behavioral level and informs the reader about its clinical relevance. The book contains ten chapters in three sections: (1) "Mechanisms of Synaptic Plasticity," (2) "Neural Plasticity," and (3) "Plasticity and Neurological Diseases." The book provides detailed and current reviews in these different areas written by experts in their respective fields. The mechanisms of synaptic plasticity and its relation to neurological diseases are featured prominently as a recurring theme throughout most chapters. This book will be most useful for neuroscientists and other scientists alike and will contribute to the training of current and future students who find the plastic nervous system as fascinating as many generations before them.
    Schlagwort(e): cognition, creb, epilepsy, microrna, neuroprotection, stem cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 33
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: The gut-brain axis has gained considerable attention from different branches of the scientific community in recent years. In this book, scientists from different disciplines present current scientific knowledge on the topic. The interaction between the prokaryote and eukaryote cells stimulates the evolutionary processes, and results in various systemic illnesses such as neuropsychiatric disorders and may help the continuity of health. Nature has provided us with healthy food that builds our pharmacy. This natural pharmacy store may help the body's healing processes through its effects on gut microbiota and the immune system. This book aims to provide the reader with detailed analyses of the current scientific knowledge on the gut-brain axis and its relation with health and disease. We hope that the reader benefits from the presented material.
    Schlagwort(e): nutrition, probiotics, microbiome, gut-brain axis, inflammation, alzheimer’s disease ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 34
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    Publikationsdatum: 2024-04-01
    Beschreibung: In recent years, due to advancing technology and diagnostic and therapeutic techniques, medicine and health care have become more patient-oriented. This concept of personalized medicine or theranostics can be traced back to the beginnings of nuclear medicine when radioisotopes were uncovered as diagnostic and therapeutic tools. Nowadays, the field of theranostics is in flux, as new techniques and materials allow a growing range of applications beneficial for patients. This book examines new developments in theranostics and provides a comprehensive overview of the state of the art in this exciting discipline.
    Schlagwort(e): graphene, nanomaterials, bioremediation, exosomes, angiogenesis, mri ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 35
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    Publikationsdatum: 2024-04-05
    Beschreibung: This edited volume Event-Related Potentials and Evoked Potentials is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of medicine and health sciences. The book comprises single chapters authored by various researchers and edited by an expert active in the field of event-related potential (ERP). An event-related potential (ERP) is the measured brain response that is the direct result of a specific sensory, cognitive, or motor event. Each chapter is complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors in noninvasive means of evaluating brain functioning and opens new possible research paths for further novel developments.
    Schlagwort(e): multiple sclerosis, cognition, pathology, electroencephalogram, topography, brain-computer interface ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 36
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    Publikationsdatum: 2024-04-01
    Beschreibung: Licorice extracts are used as additive to many Kampo medicines to alleviate pain and inflammation. With rapid progress of analytical methodology, its action mechanism is being elucidated. This book is composed of three sections. Section 1 introduces licorice as alternative medicine, its application in the industry, and the trading/market prospects between Japan and China. Section 2 summarizes the purification/identification steps of licorice ingredients and their antioxidant, antimicrobial, PPAR-? ligand-binding, antitumor, antiviral, and in vitro fertilization activities. Section 3 proposes the possible molecular mechanism by which licorice ingredients induce anti-inflammatory, antifibrosis, antihepatitis, and antileishmanial activity. All chapters are written by experts of natural sciences and economics and will surely give new insights into alternative medicines to students, clinicians, teachers, and researchers.
    Schlagwort(e): flavonoids, metabolic syndrome, diabetes, cytokines, innate immunity, in vitro fertilization ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 37
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    Publikationsdatum: 2024-04-01
    Beschreibung: To prevent bacterial adherence, invasion and infection, antimicrobials such as antibiotics are being used and vastly researched nowdays. Several factors such as natural selection, mutations in genes, the presence of efflux pumps, impermeability of the cell wall, structural changes in enzymes and receptors, biofilm formation, and quorum sensing cause microorganisms to develop resistance against antimicrobials. Isolates that synthesize extended spectrum-β-lactamases (ESBL), induced β-lactamases (IBL), carbapenamases, metallo-β-lactamases (MBLs), and New Delhi metallo-β-lactamases (NDM) have emerged. Determining virulence factors such as biofilms and the level of antimicrobial activities of antimicrobial agents alone and in combination with appropriate doses against microorganisms is very important for the diagnosis, inhibition, and prevention of microbial infection. The goal of this book is to provide information on all these topics.
    Schlagwort(e): antibiotics, natural products, screening, biofilms, cultural heritage, streptomyces ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 38
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    Publikationsdatum: 2024-04-01
    Beschreibung: In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 39
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    Publikationsdatum: 2024-04-01
    Beschreibung: The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.
    Schlagwort(e): stroke, natural products, risk management, quantum dots, magnetic nanoparticles, blood-brain barrier ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 40
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    Publikationsdatum: 2024-04-05
    Beschreibung: Peripheral nerve injuries are a high-incidence clinical problem that greatly affects patients' quality of life. Despite continuous refinement of microsurgery techniques, peripheral nerve repair still stands as one of the most challenging tasks in neurosurgery, as functional neuromuscular recovery is rarely satisfactory in these patients. Therefore, the improvement of surgical techniques and the clinical application of innovative therapies have been intensively studied worldwide. Direct nerve repair with epineural end-to-end sutures is still the gold standard treatment for severe neurotmesis injuries but only in cases where well-vascularized tension-free coaptation can be achieved. When peripheral nerve injury originates a significant gap between the nerve stumps, nerve grafts are required, with several associated disadvantages. Therefore, the development of scaffolds by tissue engineering can provide efficient treatment alternatives to stimulate optimum clinical outcome. Nerve conduit tailoring involves reaching ideal wall pores, using electrospinning techniques in their fabrication, surface coating with extracellular matrix materials, and adding of growth factors or cell-based therapies, among other possibilities. Also, intraluminal cues are employed such as the filling with hydrogels, inner surface modification, topographical design, and the introduction of neurotrophic factors, antibiotics, anti-inflammatories and other pharmacological agents. A comprehensive state of the art of surgical techniques, tissue-engineered nerve graft scaffolds, and their application in nerve regeneration, the advances in peripheral nerve repair and future perspectives will be discussed, including surgeons' and researchers' own large experience in this field of knowledge.
    Schlagwort(e): apoptosis, migration, injury, proliferation, carpal tunnel syndrome, adult neurogenesis ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 41
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    Publikationsdatum: 2024-04-05
    Beschreibung: "Mechanisms of Neuroinflammation" book explains how the neuronal cells become swollen at the moment of the blood-brain barrier disruption and how they lose their immunological isolation. A cascade of cytokines and immune cells from the bloodstream enters the nervous system, inflaming neurons and activating the glia. This produces a neuroinflammatory process that can generate different neurodegenerative diseases. Better understanding of mechanisms that are activated at the time when the damage to the brain occurs could lead to the development of suitable therapies that revert the neuronal inflammation and thus prevent further damage to the nervous system.
    Schlagwort(e): alzheimer’s disease, cytokines, neurodegeneration, traumatic brain injury, psychiatric disorders, stroke ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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  • 42
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: The role of nanoscale drug carriers for the effective and controlled delivery of drugs and candidate antigens is instrumental in developing therapeutic and vaccine interventions for cancers, infectious diseases and beyond. As teachers of immunobiology, we think this information will contribute to the development of interventional approaches. This book, therefore, will be a valuable addition to existing knowledge in many medical schools and undergraduate courses, providing up-to-date information on drugs and their delivery for maximum therapeutic effect and vaccination potential against infectious diseases, cancers and more. Novel drugs are described, with an assessment of their effective delivery and of drug resistance, especially against cancers. The book is a timely addition to the existing literature on lipid-based nanoparticles and will be a useful resource for students, researchers, and those working in the field of drugs, drug delivery, and drug resistance in infectious and inflammatory diseases.
    Schlagwort(e): cancer ; drug delivery ; targeted delivery ; nanoparticles ; immunotherapy ; nanotechnology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 43
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    Publikationsdatum: 2024-04-01
    Beschreibung: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 44
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    Publikationsdatum: 2024-04-05
    Beschreibung: The hippocampus is an important brain region, a true central hub for memory of various kinds and other processes. Neuropsychiatric disorders such as Alzheimer's disease, drug addiction, and schizophrenia are characterized by hippocampal alterations. The dentate gyrus of the hippocampus is a site exhibiting adult neurogenesis. This book covers the topic of the hippocampus from various perspectives. It discusses adult neurogenesis, effect of enriched environments on hippocampal plasticity, and long-term potentiation-associated gene expression. The book also addresses multiscale representations of complex environments and strategies in the hippocampus-dependent spatial tasks. Finally, insight into the hippocampus as a link between negative affect and relapse to psychostimulants is provided. The book collects evidence of various hippocampal functions in healthy and disordered brain.
    Schlagwort(e): neurogenesis, spatial memory, cytokines, stress, gene expression, complexity ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 45
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    Publikationsdatum: 2024-04-01
    Beschreibung: Since the beginning of times, pain treatment has been the motive of research giving birth to multiple groups of pharmacological families and therapies. Pain perception is a construction built over the biological phenomenon of signal transduction surrounded by different factors such as gender, age, and sociocultural status, among others. The concept of pain as the solely biological manifestation of defense is nowadays considered as a narrow-minded view of this topic. In this regard concepts such as newborns feel no pain or older people complain about everything therefore should not be paid attention when referring pain, are being left behind in the understanding that pain alleviation is a human right and everybody feeling pain should be helped for its relief. This book comprises many aspects of pain treatment and the drugs involved in it. From old analgesics with new mechanisms of action for pain alleviation to analgesics potential for diminishing oxidative stress; from pharmacological therapies to electrical ones, going through alternative medicine; and from pain treatment in dentistry to chronic pain therapies, also boarding the treatment of migraine, different experts share their knowledge on the topic.
    Schlagwort(e): opioids, paracetamol, nsaids, antioxidants, medicinal plants, ultrasound ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 46
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    Publikationsdatum: 2024-04-01
    Beschreibung: This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and Analysis”, and “Cocrystal Engineering”. The approaches discussed enhance the overall quality of treatment and overcome the side effects of available therapies. The book is a collection of scholarly literature relevant to pharmaceutical technology and existing pharmaceutical technologies. It is a useful reference for industrial personnel working on developing novel pharmaceutical dosage forms.
    Schlagwort(e): drug delivery ; bioactive compounds ; polymer ; bioavailability ; absorption ; hydrogels ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 47
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    Publikationsdatum: 2024-04-01
    Beschreibung: The physicochemical properties of drugs limit their delivery in terms of absorption, circulation, residence time, and so on, which in turn impacts the pharmacokinetics, pharmacodynamics, toxicity, immunogenicity, and efficacy of these drugs. Various advanced drug delivery systems can overcome such issues and improve therapeutic efficacy. Recent developments in novel drug delivery systems have opened new avenues to providing the safest, most effective, and most stable dosage forms. This book discusses advanced drug delivery systems, including oraganogels, transdermal delivery systems for chronic and acute pain, ocular systems, nanosponges for cancer targeting, and much more.
    Schlagwort(e): nanoparticles ; cancer ; cancer therapy ; gene ; nanocarriers ; acute pain ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
    Format: image/jpeg
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  • 48
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    Publikationsdatum: 2024-04-01
    Beschreibung: This edited volume is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of drug addiction. The book comprises single chapters authored by various researchers and edited by an expert active in the pertinent research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on drug addiction, and opens new possible research paths for further novel developments.
    Schlagwort(e): alcohol, epigenetic, emotion, embryo, heart rate variability, nursing ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 49
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    Publikationsdatum: 2024-04-05
    Beschreibung: This book starts with a new sub category of Autism Criminal Autistic Psychopathy and school shootings. It focuses on a number of interventions, including speech and language pathology, speech and language assessment instruments, occupational therapy, improving functional language development in autism with natural gestures, communication boards etc as well as helping people with autism using the pictorial support, training of concepts of significant others, theory of mind, social concepts and a conceptual model for empowering families of children with autism cross culturally. It also examines the issue of hyperandrogenism and evidence-based treatments of autism. In terms of assessment, it focuses on psychological and biological assessment including neurotransmitters systems, structural and functional brain imaging, coping strategies of parents, examines the intertwining of language impairment, specific language impairment and ASD, as well as implicit and spontaneous Theory of Mind reading in ASD. In terms of aetiology, it focuses on genetic factors, epigenetics, synaptic vesicles, toxicity during neurodevelopment, immune system and sex differences. It also examines the link between social cognitive anatomical and neurophysiologic biomarkers and candidate genes. This book will be relevant to all mental health professionals because autism occurs in all the different areas of psychiatry and professionals who will find it helpful will be psychiatrists, psychologists, social workers, nurses, teachers and all those working with persons with Autism including parents who nowadays are interested in knowing more and more, at a detailed level about their children or adults with autism.
    Schlagwort(e): Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 50
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    Publikationsdatum: 2024-04-01
    Beschreibung: The goal of any novel drug delivery system is to provide therapeutic benefits to the patients by increasing duration of drug action, reducing dosing frequency, and controlling drug release rate at the target site, thereby reducing unwanted side effects. Advanced Technology for Delivering Therapeutics is a reference book that covers recent developments in the field of drug delivery science and technology. The purpose of this book is to bring together descriptions of some selective technologies including new and promising nanotechnology currently being investigated for drug delivery applications. This book is a useful source of information for graduate and post-graduate students of pharmacy and biomedical science; pharmaceutical & other researchers involved in designing newer drug delivery systems both in academia and industry.
    Schlagwort(e): drug delivery, gene delivery, nanoparticle, polymers, dna, biopolymers ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 51
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    Publikationsdatum: 2024-04-01
    Beschreibung: The enormous field of this topic is clearly shown by the following facts: during the last ten years (2007-2016) around 500 papers/ year and 523 review articles are listed in the PubMed database on capsaicin, and over 200/year are under keywords of "capsaicin human". Recently, two major studies on the mortality of consumers of spicy food containing capsaicin and nonconsumers (over 350000 men and women aged 30-79 with heart disease, cancer, and stroke at baseline over 3.5 million person-years, 2004-2013) showed that the relative risk in total mortality was reduced by 14% in 10 diverse geographic areas of China (2015). Similarly, in the USA, (16,179 participants during over 2,70,000 person/year with the median of 18.9 years) the total mortality was reduced by 13% in populations consuming hot chili (2017). Recently, the book series "Progress in Drug Research" the 68th volume dealt for the first time on "Capsaicin as a Therapeutic Molecule" (Springer, Basel, 2014). Five excellent chapters are found in this book dealing with procedures of capsaicin from capsicum plants, emerging technologies to improve capsaicin delivery, capsaicinoid diversity and its human food preference, capsaicin and lipid metabolism, and predictors in treatment response to capsaicin. The results of these observations clearly indicate that the capsaicin research has changed direction to include human medical treatment with capsaicin. The book gathers knowledge from experts in basic and clinical sciences, pharmacologists, in the nutrition and food industry, in the drug industry, technologists, plant cultivators, as well as experts across a wide scale of medical branches.
    Schlagwort(e): cancer, inflammation, obesity, diabetes, drug delivery, pain ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 52
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.
    Schlagwort(e): depression, metabolism, bioavailability, absorption, hepatitis c, glucocorticoids ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 53
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    Publikationsdatum: 2024-04-01
    Beschreibung: Conventional drug administration has several issues and challenges. Drugs may not be fully absorbed or targeted, some drugs produce undesirable secondary effects and cause organ damage, and others trigger inflammation and immune response. As such, drug carrier systems are being developed to help promote drug absorption, enhance targeting, and avoid or decrease negative symptoms. This book examines different drug carriers and drug carrier systems. Chapters address such topics as the use of polymers in drug carrier systems, thin films, metal-organic frameworks, graphene quantum dots, and nanotechnology and microfluidics for drug delivery.
    Schlagwort(e): Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 54
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    Publikationsdatum: 2024-04-05
    Beschreibung: Among the components of the limbic system, the amygdala is a fascinating structure that is involved in the processes of liking and disliking and in the ways our emotions drive our actions and affect the strength of our memories. Combined with new conceptual breakthroughs, the very latest data obtained by leading world experts in amygdala function that are reviewed in this book have helped to understand how the amygdala contribute to these processes and also to a variety of neurological and neuropsychiatric pathologies. Of course, due to the rate of research advancement, all the chapters presented here correspond to precise questions addressed by experts using highly specific techniques. Therefore, each chapter should be viewed as pieces of a puzzle that represent all the different research areas that have to be taken into consideration in discussing the role of the amygdala in emotion and memory. Although the primary goal of this book is to inform experts and newcomers of some of the latest data in the field of brain structures involved in mechanisms underlying emotional learning and memory, we hope it will also help to stimulate discussion on the functional role of the amygdala and connected brain structures in these mechanisms.
    Schlagwort(e): Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 55
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    Publikationsdatum: 2024-04-01
    Beschreibung: The discovery of antibiotics was considered a milestone in health sciences and became the mainstay of antimicrobial therapy to treat and control bacterial infections. However, its utility has subsequently become limited, due to the emergence and spread of antimicrobial resistance among different bacterial species, which has emerged as a global threat. The development and spread of antimicrobial resistance have been attributed to many factors, including indiscriminate use of antibiotics in the healthcare and livestock industries. The present scenario of antibiotic resistance urgently requires interventions in terms of development of newer antimicrobials, evaluation of alternative therapies, and formulation of stringent policies to curb indiscriminate use of antimicrobials. This book highlights the importance and development of antimicrobial resistance in zoonotic, environmental and food bacteria, including the significance of candidate alternative therapies.
    Schlagwort(e): lactic acid bacteria, medicinal plants, bacteria, antibiotics, food safety, probiotics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 56
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    Publikationsdatum: 2024-04-05
    Beschreibung: This edited volume Electroencephalography is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of medicine and health sciences. The book comprises single chapters authored by various researchers and edited by an expert active in the electrophysiological monitoring method research area. Each chapter is complete in itself but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on electrophysiological monitoring method and opens new possible research paths for further novel developments.
    Schlagwort(e): eeg, motor learning, regression, hypothermia, inverse problem, ldpc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 57
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    Publikationsdatum: 2024-04-01
    Beschreibung: Pharmacogenetics is the study of the effects of individual genetics on drug responses. This book provides an overview of the current state of the pharmacological genetic aspects of these treatments. It discusses drugs with genetic information to support product labeling, clinical guidelines, or significant mechanical effects. Pharmacogenetic studies have also allowed us to better understand the pharmacology of medications used to treat neurologic and psychiatric disorders. This book also reviews the current state of the science and potential clinical utility of pharmacogenetic markers for these treatments. Furthermore, it highlights the in silico approach as a promising tool for further research on experimental pharmacology.
    Schlagwort(e): biomarkers, alzheimer’s disease, immunotherapy, neurodegeneration, hypoxia, lung cancer ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 58
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    Publikationsdatum: 2024-04-05
    Beschreibung: The dementia challenge is the largest health effort of the times we live in. The whole society has to move to a realization of the significance of prioritization to make an attempt in the direction of mental health promotion and dementia risk reduction. New priorities for research are needed to go far beyond the usual goal of constructing a disease course-modifying medication. Moreover, a full empowerment and engagement of men and women living with dementia and their caregivers, overcoming stigma and discrimination should be promoted. The common efforts and the final aim will have to be the progress of a ''dementia-constructive'' world, where people with dementia can take advantage of equal opportunities.
    Schlagwort(e): Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 59
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    Publikationsdatum: 2024-04-01
    Beschreibung: Right before the COVID-19 pandemic declared by the World Health Organization (WHO), life sciences have incited novel areas of studies that revolutionize the health sector. They are the studies of structural bioinformatics, pharmacogenomics, and metabolomics. The structural bioinformatics field is the very foundation of drug design research, as it provides insight into the molecular simulations and interactions between the biomolecules and the drug candidates. Secondly, pharmacogenomics is the starting point of any efforts in developing personalized medicine. Lastly, metabolomics provides instrumentation to elicit biomarkers for various diseases and health conditions. These studies have enabled current accelerated effort in COVID-19 research, as well as other communicable and non-communicable diseases.
    Schlagwort(e): bioactive compounds, drug discovery, genomics, proteomics, density functional theory, metabolites ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 60
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    Publikationsdatum: 2024-04-05
    Beschreibung: This book collates the contributions of a selected number of neuroscientists that are interested in the molecular, preclinical, and clinical aspects of neurotransmission research. The seven chapters in this book address the latest research/review data related to GABA/glutamate system's organization and function, the structure of receptors, subtypes and their ligands, as well as the translational approach and clinical implications. The book offers readers a rich collection of data regarding current and future applications of GABA and glutamate neurotransmission, including promising research strategies and potential clinical benefits.
    Schlagwort(e): mri, calcium, glioma, signal transduction, cns, neurological disorders ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 61
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    Publikationsdatum: 2024-04-01
    Beschreibung: Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 62
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    Publikationsdatum: 2024-04-01
    Beschreibung: The scientific monograph by the author Peter Mikus entitled "Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms; electrophoresis techniques in capillary and microchip format; electrophoretic modes such as ITP, CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking; non-electrophoretic effects such as SPE, chromatography, dialysis; combinations of these effects; multidimensional CE systems; instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 63
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    Publikationsdatum: 2024-04-01
    Beschreibung: Biopharmaceuticals are derived from biological sources, either live organisms or their active components; nowadays, they are mainly produced by biotechnologies. Biopharmaceuticals are extensively used in the treatment of various diseases such as cardiovascular, metabolic, neurological diseases, cancer, and others for which there are no available therapeutic methods. With the advance of science, biopharmaceuticals have revolutionized the treatment, prevention, and diagnosis of many patients with disabling and life-threatening diseases. Innovative biopharmaceuticals definitely improve the life quality of patients and enhance the effectiveness of the healthcare system. This book encompasses the discovery, production, application, and regulation of biopharmaceuticals to demonstrate their research achievement, prospects, and challenges. We expect the significance of biopharmaceuticals to be revealed and emphasized by this book.
    Schlagwort(e): immunotherapy, vaccine, mass spectrometry, regenerative medicine, quality control, monoclonal antibody ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 64
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    Publikationsdatum: 2024-04-05
    Beschreibung: The brain is the most complex structure that exists in the universe, consisting of neurons whose function is to receive information through dendrites and transmit information through the axon. In neurosciences one of the main problems that exists are neurodegenerative diseases for which until now there has been no cure. This book is mainly focused on updating the information on the signaling process carried out in the development of axons. Topics such as axon guidance and its interaction with the extracellular matrix are discussed. Other important topics are semaphorins and their relationship with neurodegenerative diseases, and the neurobiology of the gap junction in the dorsal root ganglion. Finally, the topic of bioelectrical interfaces destined to regenerate damaged nerves is covered. The information in this book will be very important both for researchers who work with these issues and doctoral students who are involved in neuroscience.
    Schlagwort(e): neurodegeneration, extracellular matrix, pain, neurodegenerative diseases, interface, stem cell ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 65
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    Publikationsdatum: 2024-04-01
    Beschreibung: Cannabinoids - Recent Perspectives and Applications in Human Health presents the latest research on cannabinoids for human health, covering topics such as potential emerging therapeutic applications and safety concerns. Not only does this book provide an up-to-date source of information for physicians and scientists, but it also provides insight into the wide range of potential applications for cannabinoids in health care. With this new publication, the medical community will gain a more comprehensive understanding of cannabinoids and their potential applications in human health. This book is an invaluable resource for both physicians and scientists alike.
    Schlagwort(e): toxicity ; public health ; clinical trials ; kidney ; addiction ; omics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Publikationsdatum: 2024-04-01
    Beschreibung: Drug repurposing (or drug repositioning) is defined as the process of identifying new pharmacological indications of old, existing, investigational, or FDA-approved drugs for use in the treatment of diseases other than the drugs’ original intended therapeutic use. Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery delivers up-to-date information on the identification of newer uses, molecular mechanisms, and novel targets of existing drug candidates through the application of various experimental, biophysical, and computational approaches and techniques. Chapters discuss recent advances in drug repurposing strategies that are currently being used in the discovery and development of drugs against difficult-to-treat, rare, and life-threatening diseases, including microbial infections, COVID-19, parasitic diseases, cardiovascular diseases, neurological disorders, and cancer. The book also discusses the modern experimental assays (HTS) and computational techniques including informatics and databases, molecular docking and dynamics, artificial intelligence and machine learning, virtual screening and pharmacophore modeling, proteomics and metabolomics, and network pharmacology and systems biology approaches. Some of the key features of the book are: • Presents the strategies available for the development of drugs by drug repurposing approaches through various experimental and computational techniques for the treatment of difficult-to-treat, rare, and deadly diseases • Summarizes the latest advances in the application of drug repurposing strategies, techniques, and approaches in the discovery and development of drugs • Depicts drug development approaches from existing drug candidates and/or lead molecules through modern experimental assays, biophysical tools, and computational techniques Written by a global team of experts, this book is useful for drug discovery scientists, drug developers, medicinal chemists, phytochemists, pharmacologists, clinicians, biochemists, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.
    Schlagwort(e): covid-19 ; cancer ; machine learning ; big data ; angiogenesis ; screening ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 67
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    Publikationsdatum: 2024-04-05
    Beschreibung: The prefrontal cortex reaches its greatest development in the human brain, making up nearly one third of the neocortex. Due to its remarkable evolution, the prefrontal cortex plays an important role in higher integrative functions such as information processing, thinking, understanding, attention, behavior, motivation, emotions, working memory, and analysis. This book brings together theoretical and technical research advances on the prefrontal cortex, from the basic explanations of the neuronal architecture of the prefrontal cortex and its anatomy, presenting it as a morphological substrate for many psychological conditions, through normal and altered connectivity and its manifestation in different behavior and identification of organizational levels inside the prefrontal cortex through different neuroimaging methods. It also provides an interdisciplinary view of the prefrontal cortex and its issues and discovers the main role of this part of brain in psychosocial, economic, and cultural adaptation.
    Schlagwort(e): rehabilitation, neuroimaging, metacognition, schizophrenia, childhood, pragmatics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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    Publikationsdatum: 2024-04-05
    Beschreibung: This book, Physical Disabilities - Therapeutic Implications, presents reports on a wide range of areas in the field of neurobiological disabilities, including movement disorders (Uner Tan syndrome, genetic and environmental influences, chronic brain damage, stroke, and pediatric disabilities) related to physical and stem cell therapy. Studies are presented from researchers around the world, looking at aspects as wide-ranging as the genetics, wheelchair, and robotics behind the conditions to new and innovative therapeutic approaches.
    Schlagwort(e): rehabilitation, stroke, cerebral palsy, environment, autism, stem cell therapy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 69
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    Publikationsdatum: 2024-04-01
    Beschreibung: Toxicologists seek to better understand the myriad of mechanisms responsible for neurotoxins. Because the incidence of neurobehavioral hazards and risks of exogenous compounds (e.g., natural toxins, synthetic molecules, and therapeutic agents) remain a subject matter of interest, predictive tools have evolved, including but not limited to novel translational in vitro models, biomarkers, newer epidemiological research tools, and well-accepted best practices for diagnosing neurotoxins in clinical practice. Taken together, the foreseen need to highlight some of the more appreciated and/or emerging tactical approaches in neurotoxicology results in a "one-stop reference" book, Neurotoxins.
    Schlagwort(e): neurotoxicity, heavy metals, depression, stroke, pain, proteins ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 70
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    Publikationsdatum: 2024-04-01
    Beschreibung: In the last decade, pharmacoepidemiology has emerged as an important field to study the use/effects of drugs in large populations in real life, allowing for improved benefits and effectiveness of drugs as well as a decline in drug-related risks. The correct assessment, reporting, monitoring, and prevention of adverse events in drugs’ development, as well as therapy and post-market surveillance, is essential to improve clinical therapies and health outcomes. This book provides a comprehensive and unique overview of the relevance, new insights, and recent findings of pharmacoepidemiology and drug safety in public health.
    Schlagwort(e): pharmacovigilance, adverse drug reactions, covid-19, antibiotics, elderly, adverse effects ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 71
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    Publikationsdatum: 2024-04-05
    Beschreibung: Dr. Ahmet Mesrur Halefoğlu mostly deals with research fields in body imaging and neuroradiology with multidetector computed tomography and high-resolution magnetic resonance imaging. He has served as postdoctoral research fellow at Johns Hopkins Hospital. Currently, he is working as an associate professor of radiology in Istanbul, Turkey. He has more than 50 high-impact-factor publications and has written 3 book chapters. He is a member of Turkish Society of Radiology and European Society of Radiology. During the recent years, there have been major breakthroughs in MRI due to developments in scanner technology and pulse sequencing. These important achievements have led to remarkable improvements in neuroimaging and advanced techniques, including diffusion imaging, diffusion tensor imaging, perfusion imaging, magnetic resonance spectroscopy, and functional MRI. These advanced neuroimaging techniques have enabled us to achieve invaluable insights into tissue microstructure, microvasculature, metabolism, and brain connectivity.
    Schlagwort(e): magnetic resonance imaging, mri, autism, tumor, prostate cancer, segmentation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 72
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    Publikationsdatum: 2024-04-01
    Beschreibung: The chemical basis of human emotions has been an exciting aspect in biology. The "feel-good chemical" dopamine (DA) is a hormone and also a neurotransmitter, which performs a critical role in reward and movement control in the brain. DA also performs multiple other functions outside the brain. Regulating unrelated critical biological functions makes this chemical a vital factor for sustaining life in both health and disease. Dopamine - Health and Disease is an endeavour with an objective to understand and appreciate the biological functions of DA in human wellbeing and its potential utility in biomedical research. This effort will supplement scientific and non-scientific communities in stimulating a critical understanding of the biological purpose of "ticklish" DA, which eventually supports the human relentless effort to reduce the burden of disease. As the most exciting molecule,dopamine directly impacts day-to-day life. Anyone who has an eye for health and disease-related concepts will find this book a good read.
    Schlagwort(e): electrospinning, tissue engineering, reproduction, parkinson’s disease, rodents ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Publikationsdatum: 2024-04-05
    Beschreibung: The optic nerve is a primary reference for those ophthalmologists and researchers interested in its anatomy and physiology, in the most recent diagnostic techniques, as well as in the clinical management of optic nerve disorders. The book provides a detailed description of the structure and functioning of the optic nerve and attempts at clarifying how anomalies in its development are related with tumor development. The book surveys the most recent diagnostic techniques, such as spectral domain optical coherence tomography, and highlights how these techniques can be employed to evaluate optic nerve layers as well as lesions compressing the visual pathway. Practical references to optic nerve drusen and the changes in the optic nerve due to diabetic retinopathy are also presented. The book is written in a concise fashion and aims at being a major reference to a broad audience, including students, ophthalmologist consultants, neurologists, researchers, and surgeons concerned with optic nerve diseases.
    Schlagwort(e): optical coherence tomography, diabetes mellitus, diabetic retinopathy, glioma, glaucoma, meningioma ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 74
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    Publikationsdatum: 2024-04-01
    Beschreibung: Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.
    Schlagwort(e): biotechnology, screening, toxicology, inhibitors, surface plasmon resonance, matrix ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 75
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    Publikationsdatum: 2024-04-01
    Beschreibung: Type 2 diabetes (T2D), also known as non-insulin-dependent diabetes mellitus (NIDDM), is a condition in which cells fail to respond to insulin properly. As the disease progresses, the body does not produce enough insulin. There are several classes of anti-diabetic medications available, including the oral agent metformin. This medication is recommended as first-line treatment for T2D, except for those patients with severe kidney or liver problems. This book discusses the molecular mechanism, pharmacokinetics, and uses of metformin, as well as presents information on adverse drug reactions, drug interactions, and the potential use of metformin in tuberculosis.
    Schlagwort(e): diabetes mellitus, cancer, obesity, antioxidant, insulin, glucose ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 76
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    Publikationsdatum: 2024-04-01
    Beschreibung: Corticosteroids are frequently prescribed drugs. Systemic corticosteroids possess potent anti-inflammatory, immunomodulatory, and certain antineoplastic properties, thus being pivotal in the treatment of autoimmune diseases, allergic reactions, arthritic diseases, asthma exacerbations, neurological disorders, septic shock, and selected malignancies. Moreover, topical use of corticosteroids is essential in the treatment of dermatological and ophthalmological conditions as well as chronic asthma. Finally, administration of antenatal and postnatal corticosteroids is one of the most important features of modern obstetrics and neonatology. As such, this book provides a comprehensive overview of corticosteroids, including their pharmacological properties and clinical use, and addresses uncertainness in their appropriate prescribing.
    Schlagwort(e): asthma, covid-19, inflammation, chitosan, sepsis, rheumatoid arthritis ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 77
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    Publikationsdatum: 2024-04-05
    Beschreibung: This book provides comprehensive and up-to-date insights into emerging research trends on neuroplasticity with current or future treatments for neurodevelopment and neurodegenerative diseases. The authors discuss structural and functional changes associated with cortical remapping, sensory substitution, synaptic and non-synaptic compensatory plasticity due to brain damage, brain training, chronic pain, meditation, music, exercise and related states. Key features include pathogenesis, and existing and new therapies together with a pharmacological and non-pharmacological approach in clinical treatment and management. The authors are established experts that contributed significantly to a better understanding of the etiology of neuroplasticity. This book is recommended to healthcare providers, clinical scientists, students and patients.
    Schlagwort(e): multiple sclerosis, neurorehabilitation, parkinson’s disease, stem cells, transplantation, fatigue ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 78
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Currently, there are many complicated health disorders with different etiologies and pathogeneses, including cancers, obesity, periodontitis, cardiovascular disease, liver, skin and renal disorders. It is now known that the causes and pathogenesis of many complex chronic diseases are usually polyfactorial: genetic, environmental, constitutive factors, or a combination of these. Recently, poly-target molecules containing enzymes capable of catalyzing several reactions have been efficiently used in the treatment of several metabolic disorders, and infectious and inflammatory diseases. This book describes the history of the discovery of metformin and its chemistry. Topics presented include new approaches to the role of metformin in the treatment of diabetic patients and its ability to target multiple signaling pathways.
    Schlagwort(e): type 2 diabetes ; ampk ; cancer ; diabetes ; diabetes mellitus ; insulin resistance ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 79
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: As a strategic response to cognitive and CNS impairments, BCI is a theoretical outgrowth of several generations of endogenous devices for peripheral nerves, which have as a prime goal the direct replacement of lost neural function. In these earlier applications therapeutic intervention has been premised only on the restoration of signal generating capacity where nerve transmission is largely unidirectional and temporally sequenced. It is increasingly apparent, however, that the brain not only employs a very different type of syntax from that of peripheral nerves but also structures the semantic content of motor activity, fundamentally altering the conception of BCI as a therapeutic medium. The book presented here documents this change, proposing a multi-faceted strategy in which BCI therapy can restore the loss of multi-tiered, brain based motor function.
    Schlagwort(e): eeg, motor imagery, neurorehabilitation, signal processing, autonomic nervous system, f-wave ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 80
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Alzheimer's disease was discovered over 100 years ago and still belongs to incurable neurological diseases; its pharmacotherapy is considered to be ineffective. This book presents contemporary views on the genetic, biochemical, and immunological determinants of this disease. This book also concerns the issue of Alzheimer's disease prevention through lifestyle and physical activity. Moreover, it describes the therapies used in Alzheimer's disease to slow the progression of the disease and delay its onset. Subsequently, the authors discuss experimental and clinical trials used now and in the near future. We hope that this book will help the readers to understand the complex mechanism leading to the development of Alzheimer's disease and indicate effective ways to prevent this disorder.
    Schlagwort(e): inflammation, alzheimer’s disease, dementia, microglia, mild cognitive impairment, oxidative stress ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 81
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Ever since side effects from bilateral hippocampectomy were identified in Henry Molaison (patient “HM”) during the 1950s, a critical role of the hippocampus has been recognized in the formation of declarative episodic memories. Other cognitive functions have since been proposed, such as a role in navigation, but memory has often been suggested to explain hippocampal involvement. Proving a distinct functional role in cognition is difficult, as memory can be implicated in most cognitive activities. Even when a behavior relies on memory, however, the functionality of the hippocampus extends far beyond, especially evident during activities requiring interactions between cognitive systems. Relational memory is supported by hippocampal connections with widespread regions of the cortex; these interconnections also play a fundamental role in children’s writing abilities and expertise in musical performance. Besides enhancing individual lives, such activities can play a vital role in sustaining cultural values across generations. Interactions with the environment that do not directly depend on mnemonic activity can affect plasticity in hippocampal connections, modified through natural chemicals, pharmacological drugs, and non-pharmacological behaviors. Navigational properties of the hippocampal system are not limited to memory, containing the same navigational elements as our Global Positional System (GPS). Even cognitive deficits arising from hippocampal lesions in “HM” were not limited to memory, as they included deficits in understanding cognitive relationships available in visual scenes, novel sentence contexts, and humorous situations. This book shows an expansive role of the hippocampus in cognition that goes beyond its recognized role in generating new episodic memories.
    Schlagwort(e): alzheimer’s disease ; plasticity ; robotics ; neuroplasticity ; working memory ; acetylcholine ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 82
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.
    Schlagwort(e): anticoagulants, atrial fibrillation, comorbidity, hemodialysis, heparin, anticoagulation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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    Standort Signatur Erwartet Verfügbarkeit
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  • 83
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Dosage forms are pharmaceutical formulation products in the form in which they are presented in the market. They are a crucial component of contemporary pharmaceutical research. The field of dosage forms is large and diverse and includes everything from conventional solid and liquid dosage forms to more recent innovations like nanoparticles and gene therapy. This book provides a comprehensive overview of dosage forms, including their formulation and development. Chapters address such topics as novel dosage forms in ophthalmic applications, orally disintegrating tablets, layered tablets, pharmacokinetics and pharmacogenomics, and much more.
    Schlagwort(e): pharmacokinetics ; metabolism ; liposomes ; pharmacology ; biomaterial ; tuberculosis ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 84
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Vaccination is the most effective and scientifically based means of protection against infectious diseases, especially in this era of the COVID-19 pandemic. This book examines several issues related to the development of vaccines against viral, bacterial, and parasitic infections.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 85
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Serotonin is an ancient neurotransmitter system involved in various systems and functions in the body and plays an important role in health and disease. The present volume illustrates the broadness of the involvement of serotonergic activity in many processes, focusing particularly on disorders of the brain, including depression, stress and fear, Alzheimer’s disease, aggression, sexual behavior, and neuro-immune disorders. Chapters illustrate techniques and methods used to study the complex role of the serotonergic system in all kinds of processes, present new hypotheses for several brain disorders like sleep and depression, and use mathematical modeling as a tool to advance knowledge of the extremely complex brain and body processes.
    Schlagwort(e): Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 86
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Introduced in the 1980s, biologic medications have since become important tools in modern medicine. However, biologics are expensive, greatly affecting the healthcare budgets of both underdeveloped and developed countries. Fortunately, biosimilars, which are highly similar, reverse-engineered versions of existing biological medicines and their active ingredients, are now available as more affordable options for patients treated with biologics. This book discusses biosimilars with chapters on clinical trials, regulation, pharmacovigilance, and the interchangeability of biosimilars with biologics. It also addresses future trends in the biosimilars market.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 87
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 88
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: Radiopharmaceuticals - Current Research for Better Diagnosis and Therapy discusses the importance of radiopharmaceuticals and their environmental, pharmaceutical, diagnostic, therapeutic, and research applications. Chapters address such topics as the fundamentals of radiopharmaceutical chemistry and preparation, fabrication, materials manipulation, and characterization of radiopharmaceuticals, applications of radiopharmaceuticals in preclinical studies, radiopharmaceuticals in modern cancer therapy, and new trends in preparation, biodistribution, and pharmacokinetics of radiopharmaceuticals in diagnosis and research.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 89
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-05
    Beschreibung: Brain-computer interfacing (BCI) with the use of advanced artificial intelligence identification is a rapidly growing new technology that allows a silently commanding brain to manipulate devices ranging from smartphones to advanced articulated robotic arms when physical control is not possible. BCI can be viewed as a collaboration between the brain and a device via the direct passage of electrical signals from neurons to an external system. The book provides a comprehensive summary of conventional and novel methods for processing brain signals. The chapters cover a range of topics including noninvasive and invasive signal acquisition, signal processing methods, deep learning approaches, and implementation of BCI in experimental problems.
    Schlagwort(e): Neurosciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 90
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    IntechOpen | IntechOpen
    Publikationsdatum: 2024-04-01
    Beschreibung: The book focuses on various aspects and properties of high-throughput screening (HTS), which is of great importance in the development of novel drugs to treat communicable and non-communicable diseases. Chapters in this volume discuss HTS methodologies, resources, and technologies and highlight the significance of HTS in personalized and precision medicine.
    Schlagwort(e): Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 91
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 92
    Publikationsdatum: 2024-04-05
    Beschreibung: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Schlagwort(e): QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Sprache: Englisch
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  • 93
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    Collège de France
    Publikationsdatum: 2022-02-01
    Beschreibung: La théorie de Darwin aussi bien que sa réception scientifique, littéraire et politique en France continuent d’être matière à débat. Les controverses qu’elle a suscitées à partir de la première traduction française de L’Origine des espèces en 1862 n’ont pas été le seul fait des naturalistes, des géologues ou des paléontologues. De nombreux autres savants se sont préoccupés de l’impact du darwinisme sur leur discipline, notamment en philologie, dans les mathématiques, la linguistique, la psychologie comparée, l’histoire ou la philosophie. Les auteurs des textes réunis dans Darwin au Collège de France montrent que le Collège de France constitue un point de référence idéal pour étudier les idées de Darwin et leur réception ainsi que la manière dont elles ont pu jouer sur la formation des disciplines du milieu du xixe siècle jusqu’à aujourd’hui. Parmi les défenseurs ou les adversaires français du darwinisme, on compte en effet plusieurs de ses professeurs, à commencer par Pierre Flourens, dont l’Examen du livre de M. Darwin (1864) a été l’un des premiers comptes rendus hostiles de L’Origine des espèces. D’autres figurent encore dans la liste : Ernest Renan, Edgar Quinet, Théodule Ribot, Jean-Charles Lévêque, Étienne-Jules Marey, Jean-François Nourrisson, Michel Bréal, Gabriel Tarde, Henri Bergson, Étienne Gilson. À cette liste s’ajoutent les professeurs de biologie, de médecine, de paléontologie, de neurosciences, ou d’économie politique. Le colloque, dont les contributions sur quelques-uns des savants mentionnés ci-dessus sont réunies dans le deuxième volume de la collection « Passage des disciplines », a été organisé par Alain Prochiantz et Antoine Compagnon dans le cadre du projet « Passage des disciplines : Histoire globale du Collège de France, xixe siècle - xxe siècle », qui s’intéresse à l’évolution des matières enseignées aussi bien que celles qui ont n’y ont pas été admises et qui forment un « Collège virtuel », depuis la fin du xviiie siècle jusqu’aux années 1960. Il est dirigé par Antoine Compagnon, avec la collaboration de Céline Surprenant et le soutien financier de PSL (2016-2019), et de la Fondation Hugot.
    Schlagwort(e): P ; D1-2009 ; PN1-6790 ; B1-5802 ; H1-99 ; Q1-390 ; literary criticism ; biology ; psychology ; history of sciences ; social sciences ; literary history ; higher education ; life sciences ; history of ideas ; philosophy ; research
    Sprache: Französisch
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  • 94
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Sprache: Englisch
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  • 95
    Publikationsdatum: 2024-04-11
    Beschreibung: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Schlagwort(e): TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Sprache: Englisch
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  • 96
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    Frontiers Media SA
    Publikationsdatum: 2024-04-04
    Beschreibung: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Schlagwort(e): oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 97
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Schlagwort(e): RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 98
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Schlagwort(e): RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 99
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    Frontiers Media SA
    Publikationsdatum: 2024-04-05
    Beschreibung: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Schlagwort(e): RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Sprache: Englisch
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  • 100
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    Frontiers Media SA
    Publikationsdatum: 2024-03-29
    Beschreibung: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Schlagwort(e): BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
    Sprache: Englisch
    Format: image/jpeg
    Standort Signatur Erwartet Verfügbarkeit
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