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  • Q1-390  (1,472)
  • General Chemistry
  • Limnology
  • thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
  • Frontiers Media SA  (1,133)
  • MDPI - Multidisciplinary Digital Publishing Institute  (414)
  • IntechOpen  (107)
  • Collège de France  (6)
  • 2020-2024  (1,660)
  • 1945-1949
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Keywords
Language
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  • 2020-2024  (1,660)
  • 1945-1949
Year
  • 1
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Statins are now the most widely used agents in patients with dyslipidemia, atherosclerosis and cardiovascular disease. However, their effects and mechanisms have not been fully investigated, and research continues to reveal new aspects of statins. The up-to-date content of this book will be useful to physicians in cardiovascular disease and geriatrics, and to academics conducting research on statins. It includes novel perspectives leading to new insights and advancing existing knowledge on statins.
    Keywords: Statins ; LDL-C ; HDL-C ; ASCVD ; PCSK9 Inhibitors ; NPC1L1 Inhibitor ; ACLY Inhibitors ; Endothelial Cell ; Inflammation ; Liver Injury ; Muscle Symptoms ; New-Onset Diabetes ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 2
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book, Drug Metabolism and Pharmacokinetics, delivers the latest information on biotransformation and other pharmacokinetic parameters required to assess drug safety in drug discovery and development. Drug metabolism and pharmacokinetics (DMPK) is considered a rational strategy for the design, optimization, and selection of successful drug candidates in the pre-clinical stages of drug discovery. The evaluation of various pharmacokinetic parameters such as aqueous solubility, lipophilicity, cell permeability, bioavailability, protein binding, and metabolism and elimination half-life, drug–drug interactions (DDIs), and toxicokinetics is essential for a candidate drug to become a successful therapeutic agent. This book discusses recent advances in in-silico tools and in vitro/in vivo experimental techniques applied in pharmacokinetic, metabolomic, and bioanalytical studies. Key Features: • Presents pharmacokinetic and biotransformation parameters used for pre-clinical safety evaluations • Depicts experimental and biophysical techniques used in bioanalytical and metabolomic studies • Summarizes in silico, in vitro, and in vivo methods used in drug–enzyme interactions, drug– drug interactions, and toxicokinetics Written by a global team of experts, this book is a valuable resource for drug discovery scientists, drug developers, medicinal chemists, pharmacologists, biochemists, clinicians, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.
    Keywords: thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 3
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Drug metabolism comprises the identification, characterization, and quantification of the chemicals or compounds produced in an animal or human upon administration of a drug. Research practices not only require the chemical structure but also aim to determine the pharmacological activities and/or toxicity of these compounds. This is first performed in animals, as studies attempt to identify and quantify metabolites, and later in humans, with care to further characterize metabolites that are either unique to or produced disproportionately in humans compared to animals. Characterization includes the determination of enzyme systems or other biological mechanisms that produce each identified metabolite; this information is used to predict potential drug-drug interactions with other compounds that increase or decrease metabolite formation and sources of biological variability in response or toxicity with varying patient genetics, which affect CYP isoform expression. This book’s purpose is to provide some understanding of the biology and current technology applied in the field of drug metabolism.
    Keywords: diabetes, drug discovery, phytochemicals, natural products, pharmacogenetics, biotransformation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 4
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: COVID-19 is a rampant worldwide problem. It is caused by the SARS-CoV-2 virus and is manifest in different variants. The Delta variant compromised existing therapeutic and preventive options for this disease and is beginning to be replaced by the Omicron variant. Through pharmaceutical biotechnology, three different treatment approaches to COVID-19 have been developed: computer-aided drug design (CADD); rational drug design in the wet lab; and the advanced drug delivery system. These approaches are heavily influenced by advances in life sciences, such as the development of structural bioinformatics, the establishment of nanobiotechnology as a standard approach in drug design, and major advances in structural biology such as the development of the CryoEM method. This book will focus on providing possible solutions to the ongoing COVID-19 pandemic in light of these advances in life sciences.
    Keywords: Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 5
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book intends to strike a balance between developments in research and the fact that researchers must absorb and link to scientific advances with clinical practice so that the management of diseases can be based on sound physiological concepts. This book addresses several controversial issues regarding a natural molecule with fascinating pharmacological and therapeutic effects. The book contains three sections: Section 1: Pharmacology and Therapeutic Applications of Resveratrol; Section 2: Bioavailability, Metabolism, and Mode of Action of Resveratrol; Section 3: Resveratrol and Its Role in Chronic and Degenerative Diseases. Does it Add Life to Years or Years to Life? It is our hope that this book will motivate readers to approach the evidence on the use resveratrol and thereby spark an interest in making further contributions to the current scientific debate and treatment development efforts.
    Keywords: antioxidant, aging, inflammation, oxidative stress, diabetes, autophagy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 6
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book discusses various topics in pharmacovigilance. The first section addresses such topics as approaches to minimize adverse drug reactions, different stakeholders and their importance in pharmaceutical policy development, changing needs for pharmacovigilance in the African region, machine learning applications in pharmacovigilance, and pharmacovigilance of biological drugs. The second section discusses signal detection, which is a promising approach that helps in the early identification of new, rare drug reactions (desired or undesired).
    Keywords: machine learning ; data mining ; elderly ; biosimilar ; supervised learning ; mental disorders ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 7
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The book "Drug Discovery - Concepts to Market" is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the latest drug discovery trends that have been revolutionized with up-to-date technological developments. This book comprises single chapters authored by various researchers and edited by an expert active in the drug development research area. All chapters are independently complete but united under a common research study topic. This publication aims to provide a thorough overview of the latest research efforts in this field from international authors and open new possible research paths for further novel developments.
    Keywords: obesity, apoptosis, metabolism, antimicrobial, mass spectrometry, antibiotics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 8
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Antibiotic resistance is a global health crisis. Misuse of antibiotics in humans, animals, food, and agriculture has compounded the situation. Bacterial infections have returned decades after medicines were first used. This book discusses antibiotic resistance and some of the organisms that pose immediate, serious, and alarming dangers. It highlights the need for a broader, more comprehensive approach to fighting bacterial infections, which may involve non-compound techniques (other than standard antibacterial drugs) that target bacteria or the host, such as antibodies, probiotics, phytobiotics, and vaccinations.
    Keywords: Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 9
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book brings together recent developments in the field of drug delivery. Technological advancements in the field of pharmaceutical sciences have revolutionized the patient care industry. The book serves to bridge the gap between the current research scenario and the technical knowledge provided at the pharmaceutical institutions to maximize the skills of individuals involved at any level in this domain. Chapters address topics related to the formulation and evaluation of drug delivery systems, various targeting approaches and novel tools, and design and statistical techniques employed to develop robust and effective dosage forms.
    Keywords: Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: In recent years, peptides generated from various marine organisms have attracted wide attention due to their diverse chemical structures and bioactivities, including antioxidant, immune-modulating, angiotensin-I-converting enzyme (ACE)-inhibitory, hypotensive, hypolipidemic, antiviral, cytotoxic, neurotoxic, anticoagulant, antifreeze, etc. Moreover, bioactive peptides can serve as additional functional components used in health foods, nutraceuticals, bio-preservatives, cosmetics, and pharmaceuticals. The Special Issue on “Marine Bioactive Peptides—Structure, Function, and Application” aimed to collect papers on up-to-date information regarding the preparation, structural identification, activity and functional evaluation, and application of marine bioactive peptides.
    Keywords: internal organs of Urechis unicinctus ; ultrasound-assisted enzymatic hydrolysis ; polypeptide ; antioxidant activity ; monkfish peptides ; NAFLD ; the AMPK/Nrf2 pathway ; lipid metabolism ; Siberian sturgeon (Acipenser baerii) ; cartilage ; collagen peptide ; cytoprotection ; Chlorella pyrenoidosa protein hydrolysate ; krill oil-in-water emulsion ; lipid oxidation ; Pinctada martensii purified peptides ; molecular docking ; traceless healing ; Cyclina sinensis ; pentadecapeptide ; immunomodulatory ; cyclophosphamide ; mechanism ; red alga ; Gracilariopsis chorda ; bioactive peptides ; ACE inhibitory activity ; DPP-IV inhibitory activity ; DPPH scavenging activity ; Laminaria digitata ; ACE-1 inhibition ; protein hydrolysate ; brown seaweed ; in silico analysis ; skipjack tuna (Katsuwonus pelamis) ; antioxidant peptide ; skin photoaging ; ultraviolet radiation ; protective function ; anti-apoptosis ; monkfish (Lophius litulon) ; swim bladders ; peptide ; stability ; n/a ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 11
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book provides a comprehensive overview of current knowledge of cannabinoid activity in human physiology and points out the importance of endocannabinoid system for the maintenance of human health and treatment of diseases. Each chapter has been organized with the aim to cover basic concepts in the modulation of endocannabinoid system in both physiological and pathological conditions, thanks to the integration of data from experimental animal models and clinical observations. A special focus has been put on the medical use of cannabinoids and on the targeting of endocannabinoid system as new therapeutic strategy for the prevention and treatment of human diseases. Taken together, this book targets a wide audience of basic and clinical scientists, teachers and students interested in gaining a better understanding in the field of cannabinoids.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 12
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book represents a case study based overview of many different aspects of drug development, ranging from target identification and characterization to chemical optimization for efficacy and safety, as well as bioproduction of natural products utilizing for example lichen. In the last section, special aspects of the formal drug development process are discussed. Since drug development is a highly complex multidisciplinary process, case studies are an excellent tool to obtain insight in this field. While each chapter gives specific insight and may be read as an independent source of information, the whole book represents a unique collection of different facets giving insight in the complexity of drug development.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 13
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Pharmacognosy is a term derived from the Greek words for drug (pharmakon) and knowledge (gnosis). It is a field of study within Chemistry focused on natural products isolated from different sources and their biological activities. Research on natural products began more than a hundred years ago and has continued up to now with a plethora of research groups discovering new ideas and novel active constituents. This book compiles the latest research in the field and will be of interest to scientists, researchers, and students.
    Keywords: cancer, antioxidant, drug discovery, secondary metabolites, polyphenols, traditional medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 14
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: With the increasing emergence of viral infections worldwide, researchers are working to develop new and non-conventional treatments for infectious diseases. This is particularly true for SARS-CoV-2, which initiated a pandemic in 2019. With a focus on coronavirus, this book provides an overview of antiviral agents and new approaches to drug design. It includes five chapters that address new avenues for drug discovery, reprofiling of current drugs, computer-aided drug design, and more.
    Keywords: Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 15
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Drug authentication is generally governed by critical procedures. This book presents a comprehensive overview of drug design, highlighting the steps involved from the discovery phase to product approval. Chapters address such topics as drug development processes, pharmaceutical nanoformulations and cosmeceuticals for topical use, ocular drug delivery systems, and drug development involving computer-aided drug design, machine learning, and artificial intelligence.
    Keywords: Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 16
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The area covered by this book undoubtedly includes a multidisciplinary approach. It combines and uses the wide range of methods and knowledge from a variety of disciplines in chemistry, pharmacology, and biology to synthesize new or extracted natural substances and their characterization, in terms of bioefficiency in different systems, pharmacokinetics, and pharmacodynamics. Importance is placed on revealing the interactions and effects on organisms. The process is long term, ranging from synthesis to potential testing of substances in animal studies, followed by monitoring effects on patients. The purpose is to define molecular targets of the highest efficacy of the prepared drugs, minimizing the undesirable effects. The content of this book is conceived with these intentions.
    Keywords: apoptosis, pharmacokinetics, medicinal plants, toxicity, antimicrobial resistance, cytotoxicity ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: This reprint discussed the role of retinal and optic nerve imaging in addition to its application in ophthalmic diseases and clinical medicine. It includes some high-quality articles containing original research results as well as review articles of exceptional merit.
    Keywords: rhegmatogenous retinal detachment ; optical coherence tomography angiography ; vitrectomy ; foveal avascular zone ; macular vessel density ; Boswellia serrata ; curcumin ; diabetic macular edema ; celiac disease ; OCT ; optical coherence tomography ; retinal layers ; RNFL ; quality of life ; canaloplasty ; trabeculectomy ; medical therapy ; central serous chorioretinopathy ; pachychoroid ; en face optical coherence tomography ; choroid ; choroidal vascularity index ; oculomics ; artificial intelligence ; machine learning ; deep learning ; retinal imaging ; color fundus photograph ; systemic diseases ; cardiovascular diseases ; neurodegenerative diseases ; COVID ; SARS-CoV-2 ; retinal vein occlusion ; RVO ; vaccination ; branch retinal vein occlusion ; optic disc drusen ; visible optic disc drusen ; deep convolutional neural network ; DCNN ; inceptionv3 ; dyslexia ; reading ; retina ; macula ; fovea ; parafovea ; perifovea ; thickness ; segmentation ; Best disease ; choroideremia ; inherited retinal diseases ; retinitis pigmentosa ; Stargardt disease ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 18
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: As teachers of parasite biology, we are becoming increasingly aware of the lack of detailed information and experimental approaches about drugs and drug resistance in many medical schools and undergraduate courses. Therefore, this book discusses parasite biology, antimalarial drugs and their mechanism of action, and the dynamic situation of evolving drug resistance of parasites, which has become a pressing issue. It provides insight into the plasmodium species, the role of cytokines in activating immune response during malaria infection, the importance of antimalarials as a therapeutic option, issues of drug resistance and co-resistance, and validation of evolved resistance in humanized mouse models. It is a timely addition to the existing literature on malaria parasite biology and a useful resource for students, researchers, and those working in the field of parasite biology, drugs, drug resistance of infectious diseases in general, and human malaria parasites in particular and beyond.
    Keywords: malaria, plasmodium falciparum, artemisinin, antimalarial drugs, machine learning, immunotherapy ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 19
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Botulinum Toxin - Recent Topics and Applications provides doctors and researchers with the most up-to-date information on the structure and action of botulinum toxins as well as their usage to treat a wide range of disorders. The book covers the fundamentals of botulinum toxins, including improvements in our understanding of their molecular structure and mechanism of action. Furthermore, it covers the production and formulation of botulinum toxins for clinical applications. The information contained herein will hopefully shift the paradigm of botulinum toxin research, moving it away from a focus on toxin attributes toward a focus on toxin engineering based on patient requests and physician experiences in everyday practice.
    Keywords: Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 20
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Corticosteroids have a broad spectrum of mechanisms making them useful for treating a variety of pathological entities. They are crucial drugs in clinical control in a plethora of patients, despite recent advances resulting from the availability of new molecules with great selectivity for different receptors, cells, or biological mediators. This book includes high-quality scientific reviews of corticosteroids and their numerous uses.
    Keywords: glucocorticoids, immune system, adverse effects, brain tumor, cochlear implant, meniere’s disease ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 21
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: In recent years, due to advancing technology and diagnostic and therapeutic techniques, medicine and health care have become more patient-oriented. This concept of personalized medicine or theranostics can be traced back to the beginnings of nuclear medicine when radioisotopes were uncovered as diagnostic and therapeutic tools. Nowadays, the field of theranostics is in flux, as new techniques and materials allow a growing range of applications beneficial for patients. This book examines new developments in theranostics and provides a comprehensive overview of the state of the art in this exciting discipline.
    Keywords: graphene, nanomaterials, bioremediation, exosomes, angiogenesis, mri ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 22
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Licorice extracts are used as additive to many Kampo medicines to alleviate pain and inflammation. With rapid progress of analytical methodology, its action mechanism is being elucidated. This book is composed of three sections. Section 1 introduces licorice as alternative medicine, its application in the industry, and the trading/market prospects between Japan and China. Section 2 summarizes the purification/identification steps of licorice ingredients and their antioxidant, antimicrobial, PPAR-? ligand-binding, antitumor, antiviral, and in vitro fertilization activities. Section 3 proposes the possible molecular mechanism by which licorice ingredients induce anti-inflammatory, antifibrosis, antihepatitis, and antileishmanial activity. All chapters are written by experts of natural sciences and economics and will surely give new insights into alternative medicines to students, clinicians, teachers, and researchers.
    Keywords: flavonoids, metabolic syndrome, diabetes, cytokines, innate immunity, in vitro fertilization ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 23
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: To prevent bacterial adherence, invasion and infection, antimicrobials such as antibiotics are being used and vastly researched nowdays. Several factors such as natural selection, mutations in genes, the presence of efflux pumps, impermeability of the cell wall, structural changes in enzymes and receptors, biofilm formation, and quorum sensing cause microorganisms to develop resistance against antimicrobials. Isolates that synthesize extended spectrum-β-lactamases (ESBL), induced β-lactamases (IBL), carbapenamases, metallo-β-lactamases (MBLs), and New Delhi metallo-β-lactamases (NDM) have emerged. Determining virulence factors such as biofilms and the level of antimicrobial activities of antimicrobial agents alone and in combination with appropriate doses against microorganisms is very important for the diagnosis, inhibition, and prevention of microbial infection. The goal of this book is to provide information on all these topics.
    Keywords: antibiotics, natural products, screening, biofilms, cultural heritage, streptomyces ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 24
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: In order to avoid late-stage drug failure due to factors such as undesirable metabolic instability, toxic metabolites, drug-drug interactions, and polymorphic metabolism, an enormous amount of effort has been expended by both the pharmaceutical industry and academia towards developing more powerful techniques and screening assays to identify the metabolic profiles and enzymes involved in drug metabolism. This book presents some in-depth reviews of selected topics in drug metabolism. Among the key topics covered are: the interplay between drug transport and metabolism in oral bioavailability; the influence of genetic and epigenetic factors on drug metabolism; impact of disease on transport and metabolism; and the use of novel microdosing techniques and novel LC/MS and genomic technologies to predict the metabolic parameters and profiles of potential new drug candidates.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 25
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The approaches in drug design are mainly comprised of these three multidisciplinary sciences. First, Bioinformatics has successfully gather biological data in form of biomolecular sequences, in order to construct knowledge on drug and vaccine design. It is of considerable importance for drug designers to comprehend the utilization of bioinformatics tools for resolving their research questions. Second, Nanotechnology has made possible the design and delivery of the nano-based drug. Third, Pharmaceutical Chemistry made it possible to investigate the adsorption, distribution, metabolism, and toxicology of the drug candidates in a fine-grained resolution.
    Keywords: stroke, natural products, risk management, quantum dots, magnetic nanoparticles, blood-brain barrier ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 26
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The role of nanoscale drug carriers for the effective and controlled delivery of drugs and candidate antigens is instrumental in developing therapeutic and vaccine interventions for cancers, infectious diseases and beyond. As teachers of immunobiology, we think this information will contribute to the development of interventional approaches. This book, therefore, will be a valuable addition to existing knowledge in many medical schools and undergraduate courses, providing up-to-date information on drugs and their delivery for maximum therapeutic effect and vaccination potential against infectious diseases, cancers and more. Novel drugs are described, with an assessment of their effective delivery and of drug resistance, especially against cancers. The book is a timely addition to the existing literature on lipid-based nanoparticles and will be a useful resource for students, researchers, and those working in the field of drugs, drug delivery, and drug resistance in infectious and inflammatory diseases.
    Keywords: cancer ; drug delivery ; targeted delivery ; nanoparticles ; immunotherapy ; nanotechnology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 27
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This contribution book collects reviews and original articles from eminent experts working in the interdisciplinary arena of novel drug delivery systems and their uses. From their direct and recent experience, the readers can achieve a wide vision on the new and ongoing potentialities of different drug delivery systems. Since the advent of analytical techniques and capabilities to measure particle sizes in nanometer ranges, there has been tremendous interest in the use of nanoparticles for more efficient methods of drug delivery. On the other hand, this reference discusses advances in the design, optimization, and adaptation of gene delivery systems for the treatment of cancer, cardiovascular, pulmonary, genetic, and infectious diseases, and considers assessment and review procedures involved in the development of gene-based pharmaceuticals.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 28
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Since the beginning of times, pain treatment has been the motive of research giving birth to multiple groups of pharmacological families and therapies. Pain perception is a construction built over the biological phenomenon of signal transduction surrounded by different factors such as gender, age, and sociocultural status, among others. The concept of pain as the solely biological manifestation of defense is nowadays considered as a narrow-minded view of this topic. In this regard concepts such as newborns feel no pain or older people complain about everything therefore should not be paid attention when referring pain, are being left behind in the understanding that pain alleviation is a human right and everybody feeling pain should be helped for its relief. This book comprises many aspects of pain treatment and the drugs involved in it. From old analgesics with new mechanisms of action for pain alleviation to analgesics potential for diminishing oxidative stress; from pharmacological therapies to electrical ones, going through alternative medicine; and from pain treatment in dentistry to chronic pain therapies, also boarding the treatment of migraine, different experts share their knowledge on the topic.
    Keywords: opioids, paracetamol, nsaids, antioxidants, medicinal plants, ultrasound ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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  • 29
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book discusses the theoretical and practical aspects required to formulate conventional drug dosage forms and advanced technology-based therapeutics. It is organized into four sections: “Preformulation”, “Formulation Design and Approaches”, “Characterization and Analysis”, and “Cocrystal Engineering”. The approaches discussed enhance the overall quality of treatment and overcome the side effects of available therapies. The book is a collection of scholarly literature relevant to pharmaceutical technology and existing pharmaceutical technologies. It is a useful reference for industrial personnel working on developing novel pharmaceutical dosage forms.
    Keywords: drug delivery ; bioactive compounds ; polymer ; bioavailability ; absorption ; hydrogels ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The physicochemical properties of drugs limit their delivery in terms of absorption, circulation, residence time, and so on, which in turn impacts the pharmacokinetics, pharmacodynamics, toxicity, immunogenicity, and efficacy of these drugs. Various advanced drug delivery systems can overcome such issues and improve therapeutic efficacy. Recent developments in novel drug delivery systems have opened new avenues to providing the safest, most effective, and most stable dosage forms. This book discusses advanced drug delivery systems, including oraganogels, transdermal delivery systems for chronic and acute pain, ocular systems, nanosponges for cancer targeting, and much more.
    Keywords: nanoparticles ; cancer ; cancer therapy ; gene ; nanocarriers ; acute pain ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This edited volume is a collection of reviewed and relevant research chapters, offering a comprehensive overview of recent developments in the field of drug addiction. The book comprises single chapters authored by various researchers and edited by an expert active in the pertinent research area. All chapters are complete in themselves but united under a common research study topic. This publication aims at providing a thorough overview of the latest research efforts by international authors on drug addiction, and opens new possible research paths for further novel developments.
    Keywords: alcohol, epigenetic, emotion, embryo, heart rate variability, nursing ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The goal of any novel drug delivery system is to provide therapeutic benefits to the patients by increasing duration of drug action, reducing dosing frequency, and controlling drug release rate at the target site, thereby reducing unwanted side effects. Advanced Technology for Delivering Therapeutics is a reference book that covers recent developments in the field of drug delivery science and technology. The purpose of this book is to bring together descriptions of some selective technologies including new and promising nanotechnology currently being investigated for drug delivery applications. This book is a useful source of information for graduate and post-graduate students of pharmacy and biomedical science; pharmaceutical & other researchers involved in designing newer drug delivery systems both in academia and industry.
    Keywords: drug delivery, gene delivery, nanoparticle, polymers, dna, biopolymers ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The enormous field of this topic is clearly shown by the following facts: during the last ten years (2007-2016) around 500 papers/ year and 523 review articles are listed in the PubMed database on capsaicin, and over 200/year are under keywords of "capsaicin human". Recently, two major studies on the mortality of consumers of spicy food containing capsaicin and nonconsumers (over 350000 men and women aged 30-79 with heart disease, cancer, and stroke at baseline over 3.5 million person-years, 2004-2013) showed that the relative risk in total mortality was reduced by 14% in 10 diverse geographic areas of China (2015). Similarly, in the USA, (16,179 participants during over 2,70,000 person/year with the median of 18.9 years) the total mortality was reduced by 13% in populations consuming hot chili (2017). Recently, the book series "Progress in Drug Research" the 68th volume dealt for the first time on "Capsaicin as a Therapeutic Molecule" (Springer, Basel, 2014). Five excellent chapters are found in this book dealing with procedures of capsaicin from capsicum plants, emerging technologies to improve capsaicin delivery, capsaicinoid diversity and its human food preference, capsaicin and lipid metabolism, and predictors in treatment response to capsaicin. The results of these observations clearly indicate that the capsaicin research has changed direction to include human medical treatment with capsaicin. The book gathers knowledge from experts in basic and clinical sciences, pharmacologists, in the nutrition and food industry, in the drug industry, technologists, plant cultivators, as well as experts across a wide scale of medical branches.
    Keywords: cancer, inflammation, obesity, diabetes, drug delivery, pain ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book is a fruit of a collaborative work from several international scientists. It will be a useful resource for researchers, students, and clinicians. Each individual chapter could serve as a prescribed reading for postgraduate students and clinicians specializing in and practicing clinical pharmacology and toxicology, pharmacotherapy and pharmacotherapeutics, pharmacovigilance, and toxicovigilance, as well as those involved in clinical research, drug discovery, and development. Every chapter in this book discusses and provides illustrations on the theme discussed based on authors' understanding and experience while summarizing existing knowledge. In doing so, each chapter provides a new insight that would benefit a novice as well as a seasoned reader in understanding the pharmacokinetic mechanisms and risk factors involved in the occurrence of adverse effects of drugs.
    Keywords: depression, metabolism, bioavailability, absorption, hepatitis c, glucocorticoids ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Conventional drug administration has several issues and challenges. Drugs may not be fully absorbed or targeted, some drugs produce undesirable secondary effects and cause organ damage, and others trigger inflammation and immune response. As such, drug carrier systems are being developed to help promote drug absorption, enhance targeting, and avoid or decrease negative symptoms. This book examines different drug carriers and drug carrier systems. Chapters address such topics as the use of polymers in drug carrier systems, thin films, metal-organic frameworks, graphene quantum dots, and nanotechnology and microfluidics for drug delivery.
    Keywords: Other branches of medicine ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The discovery of antibiotics was considered a milestone in health sciences and became the mainstay of antimicrobial therapy to treat and control bacterial infections. However, its utility has subsequently become limited, due to the emergence and spread of antimicrobial resistance among different bacterial species, which has emerged as a global threat. The development and spread of antimicrobial resistance have been attributed to many factors, including indiscriminate use of antibiotics in the healthcare and livestock industries. The present scenario of antibiotic resistance urgently requires interventions in terms of development of newer antimicrobials, evaluation of alternative therapies, and formulation of stringent policies to curb indiscriminate use of antimicrobials. This book highlights the importance and development of antimicrobial resistance in zoonotic, environmental and food bacteria, including the significance of candidate alternative therapies.
    Keywords: lactic acid bacteria, medicinal plants, bacteria, antibiotics, food safety, probiotics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Pharmacogenetics is the study of the effects of individual genetics on drug responses. This book provides an overview of the current state of the pharmacological genetic aspects of these treatments. It discusses drugs with genetic information to support product labeling, clinical guidelines, or significant mechanical effects. Pharmacogenetic studies have also allowed us to better understand the pharmacology of medications used to treat neurologic and psychiatric disorders. This book also reviews the current state of the science and potential clinical utility of pharmacogenetic markers for these treatments. Furthermore, it highlights the in silico approach as a promising tool for further research on experimental pharmacology.
    Keywords: biomarkers, alzheimer’s disease, immunotherapy, neurodegeneration, hypoxia, lung cancer ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Right before the COVID-19 pandemic declared by the World Health Organization (WHO), life sciences have incited novel areas of studies that revolutionize the health sector. They are the studies of structural bioinformatics, pharmacogenomics, and metabolomics. The structural bioinformatics field is the very foundation of drug design research, as it provides insight into the molecular simulations and interactions between the biomolecules and the drug candidates. Secondly, pharmacogenomics is the starting point of any efforts in developing personalized medicine. Lastly, metabolomics provides instrumentation to elicit biomarkers for various diseases and health conditions. These studies have enabled current accelerated effort in COVID-19 research, as well as other communicable and non-communicable diseases.
    Keywords: bioactive compounds, drug discovery, genomics, proteomics, density functional theory, metabolites ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Drug discovery and development process aims to make available medications that are safe and effective in improving the length and quality of life and relieving pain and suffering. However, the process is very complex, time consuming, resource intensive, requiring multi-disciplinary expertise and innovative approaches. There is a growing urgency to identify and develop more effective, efficient, and expedient ways to bring safe and effective products to the market. The drug discovery and development process relies on the utilization of relevant and robust tools, methods, models, and validated biomarkers that are predictive of clinical effects in terms of diagnosis, prevention, therapy, and prognosis. There is a growing emphasis on translational research, a bidirectional bench to the bedside approach, in an effort to improve the process efficiency and the need for further innovations. The authors in the book discuss the current and evolving state of drug discovery and development.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The scientific monograph by the author Peter Mikus entitled "Chiral Capillary Electrophoresis in Current Pharmaceutical and Biomedical Analysis" provides a comprehensive view on the advanced capillary electrophoresis techniques aimed to current chiral bioanalysis. The advances in the chiral electrophoresis analytical approaches are divided and theoretically described in three sections involving (i) advanced chiral separations for the optimization of chiral resolution (separation mechanisms; electrophoresis techniques in capillary and microchip format; electrophoretic modes such as ITP, CZE/EKC, CEC; chiral additives / pseudophases / phases), (ii) advanced sample preparation for the on-line preconcentration, sample clean-up and analyte derivatization (implementation of electrophoretic effects such as stacking; non-electrophoretic effects such as SPE, chromatography, dialysis; combinations of these effects; multidimensional CE systems; instrumental schemes), (iii) advanced combinations of detection and electrophoresis for the optimization in qualitative and quantitative evaluation (the most important universal as well as selective detection approaches such as absorption and fluorescence spectrophotometry, electrochemical detection, mass spectrometry vs. (i) and/or (ii)). Real analytical potential (benefits and limitations) of these advanced analytical approaches is emphasized by selected performance parameters of the methods and illustrated by many current practical applications including chiral analyses of drugs, their (bio)degradation products and biomarkers in pharmaceutical and biological matrices. The author wishes the readers many inspirations in the creation of new innovative approaches in the field of advanced chiral electrophoresis techniques with the aim to overcome capabilities of the current analytical techniques.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Biopharmaceuticals are derived from biological sources, either live organisms or their active components; nowadays, they are mainly produced by biotechnologies. Biopharmaceuticals are extensively used in the treatment of various diseases such as cardiovascular, metabolic, neurological diseases, cancer, and others for which there are no available therapeutic methods. With the advance of science, biopharmaceuticals have revolutionized the treatment, prevention, and diagnosis of many patients with disabling and life-threatening diseases. Innovative biopharmaceuticals definitely improve the life quality of patients and enhance the effectiveness of the healthcare system. This book encompasses the discovery, production, application, and regulation of biopharmaceuticals to demonstrate their research achievement, prospects, and challenges. We expect the significance of biopharmaceuticals to be revealed and emphasized by this book.
    Keywords: immunotherapy, vaccine, mass spectrometry, regenerative medicine, quality control, monoclonal antibody ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Cannabinoids - Recent Perspectives and Applications in Human Health presents the latest research on cannabinoids for human health, covering topics such as potential emerging therapeutic applications and safety concerns. Not only does this book provide an up-to-date source of information for physicians and scientists, but it also provides insight into the wide range of potential applications for cannabinoids in health care. With this new publication, the medical community will gain a more comprehensive understanding of cannabinoids and their potential applications in human health. This book is an invaluable resource for both physicians and scientists alike.
    Keywords: toxicity ; public health ; clinical trials ; kidney ; addiction ; omics ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Drug repurposing (or drug repositioning) is defined as the process of identifying new pharmacological indications of old, existing, investigational, or FDA-approved drugs for use in the treatment of diseases other than the drugs’ original intended therapeutic use. Drug Repurposing - Advances, Scopes and Opportunities in Drug Discovery delivers up-to-date information on the identification of newer uses, molecular mechanisms, and novel targets of existing drug candidates through the application of various experimental, biophysical, and computational approaches and techniques. Chapters discuss recent advances in drug repurposing strategies that are currently being used in the discovery and development of drugs against difficult-to-treat, rare, and life-threatening diseases, including microbial infections, COVID-19, parasitic diseases, cardiovascular diseases, neurological disorders, and cancer. The book also discusses the modern experimental assays (HTS) and computational techniques including informatics and databases, molecular docking and dynamics, artificial intelligence and machine learning, virtual screening and pharmacophore modeling, proteomics and metabolomics, and network pharmacology and systems biology approaches. Some of the key features of the book are: • Presents the strategies available for the development of drugs by drug repurposing approaches through various experimental and computational techniques for the treatment of difficult-to-treat, rare, and deadly diseases • Summarizes the latest advances in the application of drug repurposing strategies, techniques, and approaches in the discovery and development of drugs • Depicts drug development approaches from existing drug candidates and/or lead molecules through modern experimental assays, biophysical tools, and computational techniques Written by a global team of experts, this book is useful for drug discovery scientists, drug developers, medicinal chemists, phytochemists, pharmacologists, clinicians, biochemists, biomedical scientists, healthcare professionals, researchers, teaching faculty, and students.
    Keywords: covid-19 ; cancer ; machine learning ; big data ; angiogenesis ; screening ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: The crystalline state is the most commonly used as an essential solid in active pharmaceutical ingredients (API). The characterization of pharmaceutical crystals encompasses many scientific disciplines. Still, the core is crystal structure analysis, which reveals the molecular structure of essential pharmaceutical compounds. Crystal structure analysis provides important structural information related to the API's wide range of physicochemical properties, such as solubility, stability, tablet performance, color, and hygroscopicity. These properties should be understood in terms of molecular structures and interactions between molecules in crystals. Information on three-dimensional molecular structures also affords insights into the biological activity of molecules. The second reprint in the series, "Crystalline Pharmaceuticals (Volume II)" focused on the relationship between crystal structure and physicochemical properties. In particular, the new crystal structure of pharmaceutical compounds involving multi-component crystals, such as co-crystals, salts and hydrates, and polymorph crystals, were reported with interest. Such crystal structures contributed to the latest studies that combine morphology, spectroscopic, theoretical calculation, and thermal analysis with the crystallographic study. Thus, this reprint highlights the importance of crystal structure information in many areas of pharmaceutical science and presents current trends in the structure-property study of pharmaceutical crystals. The Guest Editors of this reprint hope the readers enjoy a wide variety of recent studies on "Crystalline Pharmaceuticals."
    Keywords: anastrozole ; non-covalent interactions ; halogen bonding ; lp-π interactions ; DFT ; QTAIM ; synthesis ; crystal structure ; fenclorim ; antifungal activity ; pyrimidine ; enrofloxacin ; salts ; organic acids ; solubility ; methimazole ; 1,2-bis[(1-methyl-1H-imidazole-2-yl)thio]ethane ; solid-state forms ; hydrates ; dehydration ; disordered crystal structure ; hydrogen bonding ; in silico docking ; Hirshfeld surface ; NF-κB signaling ; IKKβ inhibitor ; venetoclax ; crystals ; hydrate ; conformation ; X-ray diffraction ; nanocrystalline materials ; physicochemical characterization ; vibrational spectroscopy ; X-ray analysis ; thermal analysis ; critical quality attributes ; Disopyramide ; Terephthalic acid ; salt ; molecular packing ; slurry crystallization ; disopyramide ; phthalic acid ; metastable ; crystal structure analysis ; diclofenac ; diclofenac sodium ; hydration–dehydration mechanism ; anhydrate ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-01
    Description: This book focuses on how nanoscale systems can be used to deliver molecules to help with cancer management. It provides a broad overview of some of the key strategies for nanocarrier design. These strategies are brought together by the wide compositional variety of these systems and the diversity of molecules that may be carried. Additionally, functionalization strategies, codelivery, and combination with other treatment modalities highlight a very active research field.
    Keywords: nanostructured lipid carriers ; doxorubicin ; mucositis ; cell internalization ; albumin ; BSA ; CPP ; gold nanorods ; gold nanoprisms ; arginine-rich peptide ; glutathione ; nanoparticles ; oxidative stress ; breast cancer ; gastric cancer ; nanoparticle ; fucoidan ; d-alpha-tocopherylpoly (ethylene glycol) succinate ; combination chemotherapy ; G-quadruplex ; nucleolin ; DNA nanocages ; intracellular localization ; cancer targeting ; molecular dynamics simulations ; mesoporous silica nanoparticles ; radiotherapy ; immunotherapy ; tumor microenvironment ; abscopal effect ; magnetofection in vivo ; magnetic nanoparticles ; iron oxide ; gene delivery ; gene vectors ; codelivery nanocarriers ; photodynamic therapy ; anticancer therapies ; combination therapy ; phthalocyanine ; uterine cervical neoplasms ; photochemotherapy ; in vitro ; in vivo ; nanocarrier ; polyplexes ; siRNA delivery ; glioblastoma therapy ; amphiphilic poly(α)glutamate ; P-selectin ; prodrug ; drug delivery ; targeted therapy ; chemotherapy ; prostate cancer ; prostate-specific membrane antigen ; targeted delivery ; encapsulation ; cabazitaxel ; nanocarriers ; nanosystems ; radiosensitizer ; hypoxia ; synergism ; cancer ; photothermal therapy ; combined antitumor effect ; oxygenation ; hydrogel ; hypoxic tumor ; n/a ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Toxicologists seek to better understand the myriad of mechanisms responsible for neurotoxins. Because the incidence of neurobehavioral hazards and risks of exogenous compounds (e.g., natural toxins, synthetic molecules, and therapeutic agents) remain a subject matter of interest, predictive tools have evolved, including but not limited to novel translational in vitro models, biomarkers, newer epidemiological research tools, and well-accepted best practices for diagnosing neurotoxins in clinical practice. Taken together, the foreseen need to highlight some of the more appreciated and/or emerging tactical approaches in neurotoxicology results in a "one-stop reference" book, Neurotoxins.
    Keywords: neurotoxicity, heavy metals, depression, stroke, pain, proteins ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: In the last decade, pharmacoepidemiology has emerged as an important field to study the use/effects of drugs in large populations in real life, allowing for improved benefits and effectiveness of drugs as well as a decline in drug-related risks. The correct assessment, reporting, monitoring, and prevention of adverse events in drugs’ development, as well as therapy and post-market surveillance, is essential to improve clinical therapies and health outcomes. This book provides a comprehensive and unique overview of the relevance, new insights, and recent findings of pharmacoepidemiology and drug safety in public health.
    Keywords: pharmacovigilance, adverse drug reactions, covid-19, antibiotics, elderly, adverse effects ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-31
    Description: Robotics and intelligent systems are key technologies to promote efficient and innovative applications in the most diverse domains (industry, healthcare, agriculture, construction, mobility, etc.), performing and supporting activities that are not suitable to be performed by humans. Such activities are frequently time-consuming, repetitive tasks with low added value, which are physically demanding and/or dangerous. Nevertheless, robotics and intelligent systems face several scientific and technological challenges related to their integration and interoperability with other systems, safety, flexibility, re-configurability and autonomy. These challenges are especially relevant when robots operate in real unstructured environments and share a workspace with humans and other equipment. This reprint collects research achievements, ideas, and applications regarding advanced intelligent robotic systems, covering diverse technologies and application domains. Generically, the contributions cover optimal path-planning strategies and innovative designs for mobile manipulators, the integration of robotic and intelligent systems, grasping, manipulation, teleoperation, haptics, user experience approaches for collaborative robots, and multi-agent systems.
    Keywords: robot ; manipulator ; robotized workplace ; robotic cell ; optimization ; wear ; motion planning ; trajectory tracking ; mobile manipulator ; joint constraints ; self-collision avoidance ; manipulability ; service robot ; assistant robot ; collaborative robot ; healthcare ; elderly care ; intelligent systems ; COVID-19 ; multi-agent systems ; bigraphs ; design ; verification ; modeling ; non-functional requirements ; robot path planning ; RRT ; midpoint interpolation ; triangular rewiring ; path smoothness ; non-prehensile manipulation ; manipulation planning ; pivoting ; robotics ; mobile manipulation ; large-scale inspection ; wind turbine production ; autonomous navigation ; surface-orthogonal path planning ; intelligent robot ; flexible production ; manipulation ; intelligent control ; User eXperience ; human–robot interaction ; human–robot collaboration ; human-centered design ; augmented reality ; human factors ; omnivehicle ; omnitracks ; Mecanum rollers ; FDM ; simultaneous localization and mapping ; dual lidar inertial odometry ; IMU ; time synchronization ; tight coupling ; impact hammers ; industrial robotics ; haptic teleoperation ; underground mining ; genetic algorithm ; principal component analyses ; standard triangle language ; traveling salesman problem ; trajectory planning ; haptic recognition ; convolutional neural network ; channel attention ; spatial interactive second-order feature ; multiorder feature ; n/a ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The chemical basis of human emotions has been an exciting aspect in biology. The "feel-good chemical" dopamine (DA) is a hormone and also a neurotransmitter, which performs a critical role in reward and movement control in the brain. DA also performs multiple other functions outside the brain. Regulating unrelated critical biological functions makes this chemical a vital factor for sustaining life in both health and disease. Dopamine - Health and Disease is an endeavour with an objective to understand and appreciate the biological functions of DA in human wellbeing and its potential utility in biomedical research. This effort will supplement scientific and non-scientific communities in stimulating a critical understanding of the biological purpose of "ticklish" DA, which eventually supports the human relentless effort to reduce the burden of disease. As the most exciting molecule,dopamine directly impacts day-to-day life. Anyone who has an eye for health and disease-related concepts will find this book a good read.
    Keywords: electrospinning, tissue engineering, reproduction, parkinson’s disease, rodents ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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  • 50
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Drug discovery involves multiple disciplines, technologies, and approaches. This book selects important topics related to drug discovery, including emerging tool (Chapter 1), cutting-edge approaches (Chapters 2, 3, and 4), examples of specific therapeutic area (Chapter 5), quality control in drug development (Chapter 6), and job and career opportunities in the pharmaceutical sector, a topic rarely covered by other books (Chapter 7). This book draws knowledge from experts actively involved in different areas of drug discovery from both industrial and academic settings. We hope that this book will facilitate your efforts in drug discovery.
    Keywords: biotechnology, screening, toxicology, inhibitors, surface plasmon resonance, matrix ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Type 2 diabetes (T2D), also known as non-insulin-dependent diabetes mellitus (NIDDM), is a condition in which cells fail to respond to insulin properly. As the disease progresses, the body does not produce enough insulin. There are several classes of anti-diabetic medications available, including the oral agent metformin. This medication is recommended as first-line treatment for T2D, except for those patients with severe kidney or liver problems. This book discusses the molecular mechanism, pharmacokinetics, and uses of metformin, as well as presents information on adverse drug reactions, drug interactions, and the potential use of metformin in tuberculosis.
    Keywords: diabetes mellitus, cancer, obesity, antioxidant, insulin, glucose ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Corticosteroids are frequently prescribed drugs. Systemic corticosteroids possess potent anti-inflammatory, immunomodulatory, and certain antineoplastic properties, thus being pivotal in the treatment of autoimmune diseases, allergic reactions, arthritic diseases, asthma exacerbations, neurological disorders, septic shock, and selected malignancies. Moreover, topical use of corticosteroids is essential in the treatment of dermatological and ophthalmological conditions as well as chronic asthma. Finally, administration of antenatal and postnatal corticosteroids is one of the most important features of modern obstetrics and neonatology. As such, this book provides a comprehensive overview of corticosteroids, including their pharmacological properties and clinical use, and addresses uncertainness in their appropriate prescribing.
    Keywords: asthma, covid-19, inflammation, chitosan, sepsis, rheumatoid arthritis ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Currently, there are many complicated health disorders with different etiologies and pathogeneses, including cancers, obesity, periodontitis, cardiovascular disease, liver, skin and renal disorders. It is now known that the causes and pathogenesis of many complex chronic diseases are usually polyfactorial: genetic, environmental, constitutive factors, or a combination of these. Recently, poly-target molecules containing enzymes capable of catalyzing several reactions have been efficiently used in the treatment of several metabolic disorders, and infectious and inflammatory diseases. This book describes the history of the discovery of metformin and its chemistry. Topics presented include new approaches to the role of metformin in the treatment of diabetic patients and its ability to target multiple signaling pathways.
    Keywords: type 2 diabetes ; ampk ; cancer ; diabetes ; diabetes mellitus ; insulin resistance ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Anticoagulant drugs are among the most frequently prescribed drugs in everyday clinical practice. In the past decades, several new direct oral anticoagulants were developed that changed the anticoagulant therapy landscape considerably. This book provides an extensive overview of all the known anticoagulants that can be useful for studying different aspects of the haemostatic system or as a starting point for new drug development. It is also a valuable tool for clinicians providing a description of the mode of action and management of therapy for anticoagulant drugs used in everyday clinical practice in different clinical settings, including direct oral anticoagulants dabigatran, rivaroxaban, apixaban and edoxaban.
    Keywords: anticoagulants, atrial fibrillation, comorbidity, hemodialysis, heparin, anticoagulation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Dosage forms are pharmaceutical formulation products in the form in which they are presented in the market. They are a crucial component of contemporary pharmaceutical research. The field of dosage forms is large and diverse and includes everything from conventional solid and liquid dosage forms to more recent innovations like nanoparticles and gene therapy. This book provides a comprehensive overview of dosage forms, including their formulation and development. Chapters address such topics as novel dosage forms in ophthalmic applications, orally disintegrating tablets, layered tablets, pharmacokinetics and pharmacogenomics, and much more.
    Keywords: pharmacokinetics ; metabolism ; liposomes ; pharmacology ; biomaterial ; tuberculosis ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Vaccination is the most effective and scientifically based means of protection against infectious diseases, especially in this era of the COVID-19 pandemic. This book examines several issues related to the development of vaccines against viral, bacterial, and parasitic infections.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Introduced in the 1980s, biologic medications have since become important tools in modern medicine. However, biologics are expensive, greatly affecting the healthcare budgets of both underdeveloped and developed countries. Fortunately, biosimilars, which are highly similar, reverse-engineered versions of existing biological medicines and their active ingredients, are now available as more affordable options for patients treated with biologics. This book discusses biosimilars with chapters on clinical trials, regulation, pharmacovigilance, and the interchangeability of biosimilars with biologics. It also addresses future trends in the biosimilars market.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: This book focuses on various aspects and applications of drug repurposing, the understanding of which is important for treating diseases. Due to the high costs and time associated with the new drug discovery process, the inclination toward drug repurposing is increasing for common as well as rare diseases. A major focus of this book is understanding the role of drug repurposing to develop drugs for infectious diseases, including antivirals, antibacterial and anticancer drugs, as well as immunotherapeutics.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Radiopharmaceuticals - Current Research for Better Diagnosis and Therapy discusses the importance of radiopharmaceuticals and their environmental, pharmaceutical, diagnostic, therapeutic, and research applications. Chapters address such topics as the fundamentals of radiopharmaceutical chemistry and preparation, fabrication, materials manipulation, and characterization of radiopharmaceuticals, applications of radiopharmaceuticals in preclinical studies, radiopharmaceuticals in modern cancer therapy, and new trends in preparation, biodistribution, and pharmacokinetics of radiopharmaceuticals in diagnosis and research.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
    Language: English
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: The book focuses on various aspects and properties of high-throughput screening (HTS), which is of great importance in the development of novel drugs to treat communicable and non-communicable diseases. Chapters in this volume discuss HTS methodologies, resources, and technologies and highlight the significance of HTS in personalized and precision medicine.
    Keywords: Pharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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  • 61
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
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    Collège de France
    Publication Date: 2022-02-01
    Description: La théorie de Darwin aussi bien que sa réception scientifique, littéraire et politique en France continuent d’être matière à débat. Les controverses qu’elle a suscitées à partir de la première traduction française de L’Origine des espèces en 1862 n’ont pas été le seul fait des naturalistes, des géologues ou des paléontologues. De nombreux autres savants se sont préoccupés de l’impact du darwinisme sur leur discipline, notamment en philologie, dans les mathématiques, la linguistique, la psychologie comparée, l’histoire ou la philosophie. Les auteurs des textes réunis dans Darwin au Collège de France montrent que le Collège de France constitue un point de référence idéal pour étudier les idées de Darwin et leur réception ainsi que la manière dont elles ont pu jouer sur la formation des disciplines du milieu du xixe siècle jusqu’à aujourd’hui. Parmi les défenseurs ou les adversaires français du darwinisme, on compte en effet plusieurs de ses professeurs, à commencer par Pierre Flourens, dont l’Examen du livre de M. Darwin (1864) a été l’un des premiers comptes rendus hostiles de L’Origine des espèces. D’autres figurent encore dans la liste : Ernest Renan, Edgar Quinet, Théodule Ribot, Jean-Charles Lévêque, Étienne-Jules Marey, Jean-François Nourrisson, Michel Bréal, Gabriel Tarde, Henri Bergson, Étienne Gilson. À cette liste s’ajoutent les professeurs de biologie, de médecine, de paléontologie, de neurosciences, ou d’économie politique. Le colloque, dont les contributions sur quelques-uns des savants mentionnés ci-dessus sont réunies dans le deuxième volume de la collection « Passage des disciplines », a été organisé par Alain Prochiantz et Antoine Compagnon dans le cadre du projet « Passage des disciplines : Histoire globale du Collège de France, xixe siècle - xxe siècle », qui s’intéresse à l’évolution des matières enseignées aussi bien que celles qui ont n’y ont pas été admises et qui forment un « Collège virtuel », depuis la fin du xviiie siècle jusqu’aux années 1960. Il est dirigé par Antoine Compagnon, avec la collaboration de Céline Surprenant et le soutien financier de PSL (2016-2019), et de la Fondation Hugot.
    Keywords: P ; D1-2009 ; PN1-6790 ; B1-5802 ; H1-99 ; Q1-390 ; literary criticism ; biology ; psychology ; history of sciences ; social sciences ; literary history ; higher education ; life sciences ; history of ideas ; philosophy ; research
    Language: French
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: Anthropogenic greenhouse gas (GHG) emissions are dramatically influencing the environment, and research is strongly committed to proposing alternatives, mainly based on renewable energy sources. Low GHG electricity production from renewables is well established but issues of grid balancing are limiting their application. Energy storage is a key topic for the further deployment of renewable energy production. Besides batteries and other types of electrical storage, electrofuels and bioderived fuels may offer suitable alternatives in some specific scenarios. This Special Issue includes contributions on the energy conversion technologies and use, energy storage, technologies integration, e-fuels, and pilot and large-scale applications.
    Keywords: Q1-390 ; QC1-999 ; n/a ; PV ; GHG savings ; lithium-ion battery (LIB) ; probability prediction ; decarbonization ; supercapacitor (SC) ; least squares support vector machine ; EV fleet forecasts ; alternative maritime power (AMP) ; Markov chain ; feasibility study ; D funding ; hybrid power system ; numerical analysis ; ship structure ; optimal sizing ; cellulosic ethanol ; electric vehicles EV ; biofuel ; green ship ; R&amp ; bulk carrier ; molten carbonate fuel cell system ; sparse Gaussian process regression ; power-to-gas ; combination method ; charging infrastructure ; jet fuel ; flow characteristics ; hybrid refinery ; LNG-fueled ship ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 64
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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  • 65
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 66
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 67
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 69
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors
    Keywords: QH301-705.5 ; Q1-390 ; DNMTs ; n/a ; histone modification ; TBRS ; DNA methyltransferases ; autoinhibition ; epigenetics ; DNMT ; cell identity ; embryogenesis ; dwarfism ; DNMT3B ; germ cells ; HSAN1E ; USP7 ; DNMT3A ; DNA methyltransferase ; gene expression ; DNMT1 ; de novo DNA methylation ; DNA methyltransferase structure ; UHRF1 ; DNA methyltransferase mechanism ; allosteric regulation ; rare diseases ; DNA Methylation ; maintenance DNA methylation ; DNA methylation ; ADCA-DN ; PCC/PGL ; ubiquitination ; TETs ; DNA methyltransferase function ; molecular epigenetics ; DNA methyltransferase regulation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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    IntechOpen | IntechOpen
    Publication Date: 2024-04-01
    Description: Over the last fifty years, many studies of psychiatric medication have been carried out on the basis of psychopharmacology. At the beginning, researchers and clinicians found the unexpected effectiveness of some medications with therapeutic effects in anti-mood without knowing the reason. Next, researchers and clinicians started to explore the mechanism of neurotransmitters and started to gain an understanding of how mental illness can be. Antidepressants are one of the most investigated medications. Having greater knowledge of psychopharmacology could help us to gain more understanding of treatments. In total ten chapters on various aspects of antidepressants were integrated into this book to help beginners interested in this field to understand depression.
    Keywords: Psychopharmacology ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 74
    Publication Date: 2024-04-05
    Description: Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
    Keywords: QD1-999 ; Q1-390 ; glucose-6-phosphate dehydrogenase ; hydroxyurea/hydroxycarbamide ; n/a ; cord blood ; screening ; hemoglobin pattern ; capillary electrophoresis ; sickle cell disease ; (recommended) screening panel ; vaso-occlusive crisis ; Guthrie spots ; newborn screening) ; foetal haemoglobin ; harmonisation ; review ; birth prevalence ; G6PD deficiency ; prevention ; end-organ damage ; thalassemia ; MALDI-TOF ; IEF ; acute chest syndrome ; India ; sickle cell and thalassaemia screening programme ; ‘Getting to Outcomes’ ; newborn screening ; hemoglobinopathy ; service users ; public health engagement ; automated HPLC ; Kaduna State ; gene therapy for haemoglobinopathies ; ?-globin gene ; methods ; neonatal screening program ; malaria ; Plasmodium vivax ; sub-Saharan Africa ; patient organisations ; health policy ; pathophysiology ; Sickle Cell Disease ; mass spectrometry ; sickle cell disorder ; neonatal screening ; non-tribal ; Nigeria ; point-of-care ; HPLC ; laboratory methods ; registry ; patient advocacy ; bone marrow transplant ; anaemia ; hemoglobinopathies ; tribal ; newborn ; burden of disease ; patient representatives ; diagnostics ; policy making ; haemolysis ; Caribbean ; high performance liquid chromatography (HPLC) ; sickle cell disease (SCD) ; implementation science ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 75
    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 76
    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 77
    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 78
    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 79
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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  • 80
    Publication Date: 2022-01-31
    Description: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Keywords: Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
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  • 81
    Publication Date: 2024-04-05
    Description: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Keywords: QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 82
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Keywords: QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 83
    Publication Date: 2024-04-05
    Description: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Keywords: RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: This Special Issue contains one review and five original articles, all of which address cutting-edge research in the field of water and environmental virology. The review article by Gerba and Betancourt summarizes the current status and future needs for the development of virus detection methods in water reuse systems, especially focusing on methods to assess the infectivity of enteric viruses. Original papers cover a variety of research topics, such as an environmental monitoring survey of group A rotaviruses in sewage and oysters in Japan, the occurrence and genetic diversity of noroviruses and rotaviruses in a wastewater reclamation system in China, the detection of viruses and their indicators in tanker water and its sources in Nepal, integrated culture next-generation sequencing to identify the diversity of F-specific RNA coliphages in wastewater, and the development of a portable collection and detection method for viruses from ambient air and its application to a wastewater treatment plant.
    Keywords: Q1-390 ; reuse ; aerosols ; viral indicator ; wastewater treatment ; microbial contamination ; index virus ; real-time PCR ; tanker water ; virus ; wastewater reclamation ; pathogenic virus ; infectivity ; chlorination ; molecular methods ; wastewater ; next-generation sequencing ; fecal source tracking ; oyster ; fecal-source marker ; viral contamination ; cell culture ; pathogenic microorganisms ; rotavirus ; ultraviolet disinfection ; F-specific RNA bacteriophage strain ; sewage ; waterborne gastroenteritis viruses ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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  • 85
    Publication Date: 2024-04-05
    Description: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Keywords: RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 86
    Publication Date: 2024-03-29
    Description: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Keywords: BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 87
    Publication Date: 2024-04-05
    Description: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Keywords: RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 88
    Publication Date: 2024-04-05
    Description: Photosystem II is a 700-kDa membrane-protein super-complex responsible for the light-driven splitting of water in oxygenic photosynthesis. The photosystem is comprised of two 350-kDa complexes each made of 20 different polypeptides and over 80 co-factors. While there have been major advances in understanding the mature structure of this photosystem many key protein factors involved in the assembly of the complex do not appear in the holoenzyme. The mechanism for assembling this super-complex is a very active area of research with newly discovered assembly factors and subcomplexes requiring characterization. Additionally the ability to split water is inseparable from light-induced photodamage that arises from radicals and reactive O2 species generated by Photosystem II chemistry. Consequently, to sustain water splitting, a “self repair” cycle has evolved whereby damaged protein is removed and replaced so as to extend the working life of the complex. Understanding how the biogenesis and repair processes are coordinated is among several important questions that remain to be answered. Other questions include: how and when are the inorganic cofactors inserted during the assembly and repair processes and how are the subcomplexes protected from photodamage during assembly? Evidence has also been obtained for Photosystem II biogenesis centers in cyanobacteria but do these also exist in plants? Do the molecular mechanisms associated with Photosystem II assembly shed fresh light on the assembly of other major energy-transducing complexes such as Photosystem I or the cytochrome b6/f complex or indeed other respiratory complexes? The contributions to this Frontiers in Plant Science Research Topic are likely to reveal new details applicable to the assembly of a range of membrane-protein complexes, including aspects of self-assembly and solar energy conversion that may be applied to artificial photosynthetic systems. In addition, a deeper understanding of Photosystem II assembly — particularly in response to changing environmental conditions — will provide new knowledge underpinning photosynthetic yields which may contribute to improved food production and long-term food security.
    Keywords: QK1-989 ; Q1-390 ; Arabidopsis thaliana ; photoactivation ; photosynthesis ; Chlamydomonas reinhardtii ; cyanobacteria ; biogenesis ; Photosystem II ; photodamage ; Nicotiana tabacum ; Synechocystis sp. PCC 6803 ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 89
    Publication Date: 2024-04-01
    Description: The year 2017 marks the 20th anniversary of the molecular cloning of the long sought-after capsaicin receptor, now known as TRPV1 (Transient Receptor Potential Vanilloid 1). This seminal discovery has opened up a “hot” new field of basic research and launched drug discovery efforts into the large family (by the latest count, 28 mammalian members and 27 in humans) of TRP ion channels. Indeed, it took less than a decade for the first potent, small molecule TRPV1 antagonists to enter phase 1 clinical trials, closely followed by TRPA1 and TRPM8 antagonists. The literature on TRP channels is immense. TRPV1 alone is a keyword in over 5000 publications searchable in PubMed. Clearly, it is not possible to capture the entire literature in a single thematic issue. Consequently, the selection of articles presented in this book represents a sampling of the literature, and is admittedly subjective. We tried to survey the wide range of human diseases in which TRP channels have been implicated, ranging from chronic pain through asthma and diabetes to cancer, and highlight the channels that appear to hold the greatest promise for therapeutic targeting. With this book, we hope to convince readers that TRP channels constitute a formidable family of potential therapeutic targets that will likely continue to demand attention.
    Keywords: RM1-950 ; resiniferatoxin ; pain ; TRPA1 ; TRPV3 ; TRPV1 ; TRP channels ; TRPM2 ; respiratory disorders ; permanent analgesia ; capsaicin ; TRPM7 ; cancer ; TRPM8 ; diabetes ; obesity ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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  • 90
    Publication Date: 2024-04-05
    Description: Big data is revolutionizing our ability to measure and study the human brain. New technology increases the resolution of images that are being study as well as enables researchers to study the brain as it functions. These technological advances are combined with efforts to collect neuroimaging data on large numbers of subjects, in some cases longitudinally. This combination of advances in measurement and scope of studies requires novel development in the statistical analysis. Fast, scalable, robust and accurate models and approaches need to be developed to make headway on these problems. This volume represents a unique collection of researchers providing deep insights on the statistical analysis of big neuroimaging data.
    Keywords: RC321-571 ; Q1-390 ; fMRI ; Neuroscience ; functional connectivity ; EEG ; Classification ; prediction ; big data ; MEG ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 91
    Publication Date: 2024-03-29
    Description: A conversation between two people can only take place if the words intended by each speaker are successfully recognized. Spoken word recognition is at the heart of language comprehension. This automatic and smooth process remains a challenge for models of spoken word recognition. Both the process of mapping the speech signal onto stored representations for words, and the format of the representation themselves are subject to debate. So far, existing research on the nature of spoken word representations has focused mainly on native speakers. The picture becomes even more complex when looking at spoken word recognition in a second language. Given that most of the world’s speakers know and use more than one language, it is crucial to reach a more precise understanding of how bilingual and multilingual individuals encode spoken words in the mental lexicon, and why spoken word recognition is more difficult in a second language than in the native language. Current models of native spoken word recognition operate under two assumptions: (i) that listeners’ perception of the incoming speech signal is optimal; and (ii) that listeners’ lexical representations are accurate. As a result, lexical representations are easily activated, and intended words are successfully recognized. However, these assumptions are compromised when applied to a later-learned second language. For a variety of reasons (e.g., phonetic/phonological, orthographic), second language users may not perceive the speech signal optimally, and they may still be refining the motor routines needed for articulation. Accordingly, their lexical representations may differ from those of native speakers, which may in turn inhibit their selection of the intended word forms. Second language users also have to solve a larger selection challenge—having words in more than one language to choose from. Thus, for second language users, the links between perception, lexical representations, orthography, and production are all but clear. Even for simultaneous bilinguals, important questions remain about the specificity and interdependence of their lexical representations and the factors influencing cross-language word activation. This Frontiers Research Topic seeks to further our understanding of the factors that determine how multilinguals recognize and encode spoken words in the mental lexicon, with a focus on the mapping between the input and lexical representations, and on the quality of lexical representations.
    Keywords: BF1-990 ; Q1-390 ; Phonological knowledge ; Second-language speech ; bilingual and bidialectal lexicon ; spoken word recognition ; lexical access ; orthographic knowledge ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 92
    Publication Date: 2024-03-31
    Description: This forum of comprehensive reviews and research studies on distinct aspects of the pathophysiology of BAV aortopathy provides both the state of the art in the knowledge on this complex disease and novel insights into its causes and consequences. The present collection of focused papers also envisions and proposes new therapeutic strategies, novel biomarkers and original risk stratification criteria, for the improvement of patient management.
    Keywords: QP1-981 ; Q1-390 ; smooth muscle cells ; microRNAs ; aortic root ; endothelial cells ; aortic surgery ; bicuspid aortic valve ; 4DFlow analysis ; aortopathy ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 93
    Publication Date: 2024-03-29
    Description: This research topic stems from the "Interdisciplinary Approaches to Multilingualism" conference, which was hosted by the Language Research Centre at the University of Calgary. It was the first conference of its kind, which brought together the work of researchers, educators, and policy makers in the areas of first and second language acquisition from psycholinguistic and pedagogical perspectives. The goal was to provide an opportunity for participants to engage with the implications of multilingualism from a range of perspectives, including the effects of being bilingual from infancy to adulthood, the process and benefits of learning multiple languages, and the impact of multilingualism on society.
    Keywords: BF1-990 ; Q1-390 ; Developmental psycholinguistics ; second language literacy development ; Multilingualism ; psycholinguistic research methods ; Second language pedagogy ; bilingualism ; Second Language Acquisition ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: “Personalised Nutrition” represents any initiative that attempts to provide tailor-made healthy eating advice based on the nutritional needs of each individual, as these are dictated by the individual’s behaviour, phenotype and/or genotype, and their interactions. This Special Issue of Nutrients is dedicated to the development, implementation and assessment of the effectiveness of evidence-based “Personalised Nutrition” strategies. In this regard, a selection of reviews and original research manuscripts will bring together the latest evidence on how lifestyle habits, physiology, nutraceuticals, gut microbiome and genetics can be integrated into nutritional solutions, specific to the needs of each individual, for maintaining health and preventing diseases.
    Keywords: QH301-705.5 ; Q1-390 ; TX341-641 ; n/a ; gene-based ; taste ; postprandial leptin ; children ; personalised ; obesity ; macronutrient composition ; gastrointestinal symptoms ; postprandial adiponectin ; formula diet ; avoidance diet ; weight loss ; weight ; omega-3 fatty acids ; microbiome ; genotype ; nutrition ; direct-to-consumer test ; intervention ; clinical nutrition ; postprandial total ghrelin ; dietary intervention ; microbiota ; low-carbohydrate diet ; insulin ; FADS polymorphism ; adults ; genetics ; diet ; healthcare professionals ; HbA1c ; PROX1 gene ; phenotype ; high-fat meal ; glucose ; personalised nutrition ; irritable bowel syndrome ; dietary recommendation ; postprandial metabolic fingerprinting ; type 2 diabetes mellitus risk ; high-carbohydrate meal ; health ; ultra-high performance liquid chromatography ; food allergy ; normo-carbohydrate meal ; nutrimetabolomics ; type 2 diabetes ; nutrigenetics ; gene–diet interaction ; personalized nutrition ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
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  • 95
    Publication Date: 2024-04-05
    Description: In the last decade, sleep spindles have attracted steadily increasing attention. This interest is motivated by the many intriguing relationships between spindles and various diseases (e.g., schizophrenia, Parkinson, Alzheimer, autism, mental retardation), recovery processes (e.g., post brain stroke), and cognitive faculties (e.g., memory consolidation, intelligence, dream recall, sleep preservation). Nonetheless, a methodological wall has impeded the study of sleep spindles. Their investigation rests heavily on our ability to reliably and consistently identify spindle patterns from background EEG activity, a task involving many obstacles, including: a fuzzy definition of spindles, low inter-expert agreement on their scoring, lack of consensus on standard techniques for their automated detection, low reproducibility of observed characteristics and correlates, unavailability of large, standardized, high-quality databases, and inconsistencies in the methods used to evaluate the performance of automated detectors. The primary aims of this research topic were to bring together world-class researchers on a project designed to facilitate exchanges on methodological difficulties encountered in assessing sleep spindles and to promote standardized spindle-related resources. In preparing their contributions, authors were encouraged to use existing – or to propose new – publicly available resources for assessing sleep spindles. To allow fair and accurate comparison of reported results, the authors were also encouraged to validate their tools on a common benchmark. A database containing expert spindle scoring (i.e., the Montreal Archive of Sleep Studies) was made publicly available for that purpose.
    Keywords: RC321-571 ; Q1-390 ; Neural oscillations ; Electroencephalography (EEG) ; Sleep ; Sleep Spindles ; Memory ; IQ ; sigma waves ; automatic detection ; biomarker ; Open access ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 96
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: Energy metabolism is central to life and altered energy expenditure (EE) is often cited as a central mechanism responsible for development of the obese phenotype. Resting EE, EE of physical activity, cold induced thermogenesis and thermic effect of feeding add to produce total EE but can also affect each other. It is thus very important that each component be well measured. Measuring energy expenditure by indirect calorimetry is extremely simple in theory but the practice if far more difficult. Taking into account temperature in small sized animals, measuring accurately the effect of activity on EE, correcting EE for body size body composition, age sex etc… add difficulties in producing reliable data. The goal of this Research Topic was to call for the practical experience of main investigators trained to practice calorimetry in order to get their feedback and the way they deal with the various and specific problems of humans and animal calorimetry. The goal is to share the questions/solutions experienced by the contributors to inititate a “guide of the good practices” that can be periodically updated and used by all those who are and will be interested in measuring energy metabolism from the 20g mouse to the human and large farm animals.
    Keywords: QP1-981 ; Q1-390 ; Body Composition ; Thermogenesis ; brown adipose tissue ; Body Size ; Energy Expenditure ; indirect calorimetry ; physical activity ; metabolic Phenotyping ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 97
    Publication Date: 2023-12-20
    Description: Landscapes have long been viewed as ‘multifunctional’, integrating ecological, economic, sociocultural, historical, and aesthetic dimensions. Landscape science and public awareness in Europe have been progressing in leaps and bounds. The challenges involved in landscape-related issues and fields, however, are multiple and refer to landscape stewardship and protection, as well as to the development of comprehensive theoretical and methodological approaches, in tandem with public sensitization and participatory governance and in coordination with appropriate top-down planning and policy instruments. Landscape-scale approaches are fundamental to the understanding of past and present cultural evolution, and are now considered to be an appropriate spatial framework for the analysis of sustainability. Methods and tools of landscape analysis and intervention have also gone a long way since their early development in Europe and the United States. Although significant progress has been made, there remain many issues which are understudied or not investigated at all—at least in a Mediterranean context. This Special Issue addresses the application of landscape theory and practice in the Eastern Mediterranean and mainly, but not exclusively, reports on the outcomes of an international conference held in Jordan, in December 2015, with the title “Landscapes of Eastern Mediterranean: Challenges, Opportunities, Prospects and Accomplishments”. The focus of this Special Issue, landscapes of the Eastern Mediterranean region, thus constitutes a timely area of research interest, not only because these landscapes have so far been understudied, but also as a rich site of strikingly variegated, long-standing multicultural human–environmental interactions. These interactions, resting on and taking shape through millennia of continuity in tradition, have been striving to adapt to technological advances, while currently juggling with manifold and multilayered socioeconomic and climate–environmental crises.
    Keywords: G1-922 ; Q1-390 ; n/a ; landscape archaeology ; Cyprus ; Landscape Character Assessment (LCA) ; Eastern Mediterranean ; Land Description Units ; stakeholders’ analysis ; UK ; local authority ; ancient sanctuaries ; East Med landscape ; Twain-born Border Lord ; Landscape Decision Support System ; mapping ; topography ; Byzantine landscape and garden art ; economy ; LCA ; classification ; churches ; Arabic-speaking ; participatory ; Landscape Risk Assessment Model ; landforms ; GIS ; planning ; typology ; Greek-speaking ; public realm ; landscape changes ; sacred space ; comparative study ; urban environment ; ideology ; political power ; Arabic landscape and garden art ; cultural sustainability ; historical maps ; religion ; rural land ; multi-functional landscapes ; Lebanon ; Mediterranean ; geographical information system ; spatial distributions ; Land Description Unit (LDU) ; political sustainability ; landscape ; landscape character assessment ; governance ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography
    Language: English
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  • 98
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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  • 99
    Publication Date: 2024-04-05
    Description: Helicases are the proteins that bind to double- or single-stranded DNA and/or RNA chains to unwind higher order structures, usually consuming energy from the hydrolysis of ATP molecules. The biological roles of helicases are associated with a variety of DNA and/or RNA metabolisms, including DNA-replication, -repair, -recombination, RNA processing, and transcription. Dysfunctions of helicases cause various diseases, such as xeroderma pigmentosum (XP), premature aging syndrome, cancer and immunodeficiency, in humans. Moreover, recent genetic analyses revealed that mutations in helicase-encoding genes are frequently found in patients of specific diseases. Some helicases regulate cellular senescence by controlling integrity of genomes, and others play a role in neuromuscular functions presumably by modulating processing of mRNAs. However, the molecular mechanisms of how helicases are regulated in order to maintain our health are not yet fully understood. In this research topic, we will focus on the expression and functions of helicases and their encoding genes, reviewing recent research progresses that provide new insights into development of clinical and pharmaceutical treatments targeting helicases.
    Keywords: QH426-470 ; Q1-390 ; DNA Repair ; Aging ; helicases ; Telomere ; Cancer ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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  • 100
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-20
    Description: The practical importance of economic valuation information can hardly be overstated. Coastal and marine resource policy planning and management benefit from complete information on the impact of policy decisions.
    Keywords: Q1-390 ; internet survey ; open access ; contingent valuation method ; coastal management ; tourism ; Thailand ; marine ; wetlands ; harmful algae blooms ; environmental valuation ; quota ; cyanobacteria ; estuarine and coastal ecosystems ; wealth accounting ; seawater quality ; economic analysis ; remote sensing ; ecosystem restoration ; coastal ecosystems ; random utility model ; contingent behavior ; public policy ; habitat–fishery linkages ; Barbados ; coastal ecosystem services valuation ; fishery ; mangroves ; ecosystem services valuation ; coral reefs valuation ; recreational boating ; regulated open access ; non-market value ; economic valuation ; ecosystem services ; coastal ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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