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  • bic Book Industry Communication::M Medicine  (628)
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  • MDPI - Multidisciplinary Digital Publishing Institute  (946)
  • 2020-2024  (946)
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  • 2020-2024  (946)
  • 1970-1974
  • 1910-1914
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Metronomic chemotherapy is now, finally, in clinical use. After 20 years of preclinical development and clinical trials, the emerging data will be of paramount importance in allowing us to assess the impact of metronomic chemotherapy on different tumor types. Indeed, it is likely that the next decade will see a major reassessment of the possible applications of metronomic chemotherapy, both alone and in combination with new therapeutic approaches such as immunotherapies, for the management of cancer. Moreover, the results of clinical trials will likely profoundly affect the direction of the laboratory efforts that are going on in parallel and aiming to improve the personalization of this therapeutic strategy. This Special Issue is our attempt to cover the past and present clinical results that have brought us to this pivotal moment and will form the basis of future clinical developments. Scientists and clinicians caring for cancer patients are well aware of the challenges in dealing with this particular therapeutic approach; one such challenge is obtaining improvements in patient survival without significant toxicity. This edition includes clinical research on chemotherapy and ongoing controversies related to metronomic chemotherapy.
    Keywords: metronomic ; oral cancer ; oral squamous cell carcinoma ; metronomic chemotherapy ; metastatic castration-resistant prostate cancer ; cyclophosphamide ; side effects ; pediatric tumors ; etoposide ; valproic acid ; prostate cancer ; CRPC ; castration ; capecitabine ; paclitaxel ; immunomodulation ; angiogenesis ; microbiome ; breast cancer ; safety ; preclinical studies ; clinical studies ; pharmacokinetic studies ; biomarkers ; chemo-free ; DLBCL ; diffuse-large-b-cell-lymphoma ; elderly ; frail ; comprehensive geriatric assessment ; chemo-endocrine therapy ; FulVEC ; pediatric oncology ; brain tumors ; pharmacology ; medulloblastoma ; ATRT ; immunotherapy ; lymphoma ; vinorelbine ; checkpoint inhibitors ; bic Book Industry Communication::M Medicine
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This collection of articles provides insight into the mental health and nursing care of individuals who are confronting a life-threatening illness. As individuals face a cancer diagnosis, there will be many challenges and changes in their lives. Emotional distress can emerge to greater and lesser degrees. Frequently, these individuals will require additional assistance to cope with the emotional distress they experience. Nurses have an important role in assessing this emotional distress and providing relevant interventions.
    Keywords: Latinx ; family ; meaning ; communication ; coping with advanced cancer ; delirium ; liaison nurse ; misrecognition of delirium ; coordination ; breast cancer ; psychological distress ; quality of life ; women’s health ; qualitative study ; cancer care ; older adults ; mental health ; feeling safe ; home-dwelling ; patients with terminal cancer ; caregivers ; competency in anticipatory grief counseling ; emotional care ; person-centered care ; qualitative research ; anxiety ; depression ; family involvement ; hepatocellular carcinoma ; palliative care ; cancer ; decision-making ; nurse ; caregiving self-efficacy ; family caregiver ; oral cancer ; oncology ; nursing ; clinical nurse specialists ; cancer patients ; expanding nurses’ authority ; professionalization ; policy ; education ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Obstructive sleep apnea is a highly prevalent disorder with strong associations with cardiovascular, cerebrovascular, metabolic, and cognitive consequences, including drowsy driving. Positive Airway Pressure treatment is the first-line therapy for adults with obstructive sleep apnea who are symptomatic. However, many individuals with comorbidities do not report symptoms that are associated with the disorder, and adherence to treatment is poor, especially in individuals with cardiovascular diseases. This reprint contains reviews and original articles that aim to update the current perspectives on the treatment modalities of obstructive sleep apnea to highlight multidisciplinary approaches, personalized treatment strategies, and the identification of the predictors of a patient’s response to treatment, both in the general population and in clinical cohorts.
    Keywords: obstructive sleep apnea (OSA) ; continuous positive airway pressure (CPAP) ; mandibular advancement devices ; upper airway surgery ; drowsy driving ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 5
    Publication Date: 2024-01-08
    Description: Therapeutic drug monitoring (TDM) has emerged as a useful tool for optimizing biological treatment in patients with inflammatory bowel disease (IBD) and other immune-mediated inflammatory diseases (IMID). Reactive TDM has rationalized the management of primary non-response and secondary loss of response to biologics, while cumulative evidence suggests that proactive TDM is efficacious for optimizing anti-tumour necrosis factor (anti-TNF) therapy in patients with IBD. Proactive TDM can be very useful for optimizing biological therapy in specific IBD populations, such as pregnant women as well as patients with perianal fistulizing Crohn’s disease and acute severe ulcerative colitis who are characterized by high drug clearance. Preliminary data suggest that proactive TDM may also have a role in de-escalating anti-TNF therapy in patients in clinical remission including stopping the immunomodulator when combined with anti-TNF therapy. However, several knowledge gaps and limitations hinder the wide implementation of TDM in clinical practice, including the optimal drug concentration to target the lag time between sampling and results and the lack of harmonization of TDM assays. Recent advances regarding the role of TDM include the use of rapid point-of-care assays and the incorporation of model-informed precision dosing. The aim of this Special Issue is to highlight the clinical utility of TDM and discuss the barriers and recent advances of TDM of biologics in IBD and other IMID.
    Keywords: ulcerative colitis ; Crohn&rsquo ; s disease ; inflammatory bowel disease ; infliximab ; adalimumab ; certolizumab pegol ; golimumab ; vedolizumab ; ustekinumab ; therapeutic drug monitoring ; immunogenicity ; rheumatoid arthritis ; ankylosing spondylitis ; psoriasis ; clearance ; model informed precision dosing ; bic Book Industry Communication::M Medicine
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Inflammatory bowel disease (IBD) encompasses chronic idiopathic relapsing and remitting gastrointestinal autoimmune diseases characterized by chronic inflammatory disorders of complex etiology, posing clinical challenges due to their often therapy-refractory nature. The primary disorders within the IBD classification are ulcerative colitis (UC) and Crohn’s disease (CD), sharing similarities but exhibiting distinct differences, sometimes making their discrimination challenging.A prominent feature of IBD is the inflammation of the intestinal mucosa, characterized by the robust and persistent infiltration of immune cells and compromised intestinal barrier integrity, leading to a phenomenon known as “leaky gut.” Inflammation can manifest acutely or chronically, known as relapsing, and can increase in severity over time, thereby causing life-long morbidities and reduced quality of life for affected individuals, underscoring the need for a deeper comprehension of the molecular contributors to disease pathogenesis and progression.
    Keywords: inflammatory bowel diseases ; cell autofluorescence ; immune cells ; NADH ; FAD ; flow cytometry ; multiphoton microscopy ; colitis ; colitis-associated cancer ; inflammatory bowel disease ; colorectal cancer ; colon adenocarcinoma ; ulcerative colitis ; Crohn’s disease ; cDNA microarray ; transciptomics analysis ; microarray ; inflammatory bowel diseases (IBDs) ; vasculature ; angiogenesis ; gut vascular barrier ; vessel permeability ; epithelial barrier ; homeostasis ; acetylcholine ; muscarinic receptor ; non-neuronal acetylcholine ; mucosal wound healing ; ferroptosis ; leaky gut ; inflammatory bowel disease (IBD) ; triple-culture ; Caco-2 ; HT29-MTX-E12 ; THP-1 ; monocyte-derived macrophage ; inflammation ; TEER ; FITC-dextran 4 kDa (FD4) ; pro-inflammatory cytokines ; HIF-1α ; PHD2 ; AKT ; intestinal epithelial cells ; probiotics ; LPS ; antigen-specific T-cells ; celiac disease ; gliadin ; IBD ; food antigens ; intestinal Behcet’s disease ; immune mechanism ; biological agents ; claudin ; tight junctions ; barrier function ; gut ; ZO-1 ; actin ; cell migration ; cell division ; colon cancer ; PMNs ; LDs ; FOXO3 ; n/a ; bic Book Industry Communication::M Medicine
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The Special Issue entitled “Advances in Rock Mechanics and Geotechnical Engineering” is devoted to the publication of the latest research, field works, and laboratory investigations in the area of rock mechanics and geotechnical engineering. This Special Issue has published novel contributions in different areas of geotechnical and geomechanical engineering such as slope and embankment, tunneling and underground space technologies, pile and foundation, rock mechanics and rock blasting, excavation and leveling projects, ground improvement techniques, unsaturated soil, practical issues in soft soil, mining technology, geo-environmental engineering, new laboratory testing, applied geology for construction, and novel geotechnical construction methods. The focus of this reprint is on the development of computational methods for solving problems in the fields of rock mechanics and geotechnical engineering.
    Keywords: strength prediction ; brittle rock ; grain-structure representation ; micro-properties ; bonded block models ; Voronoi tessellation ; structure-type rockburst ; evolution mechanism ; particle flow code ; flat-joint model ; pre-grouting ; soft coal mass ; coal-grout structure ; shear behavior ; quality improvement ; rock strength ; tensile behaviour ; neuro-fuzzy ; regression ; non-destructive tests ; paste filling ; slicing mining ; false roof stability ; optimal false roof thickness ; tree-based techniques ; feature selection ; pile bearing capacity ; gradient boosted tree ; random forest ; in situ stress ; rock blasting ; crack propagation ; model test ; rheological deformation ; key stratum ; roadway groups ; roadway deformation ; surrounding rock control ; triaxial creep experiment ; cyclic loading and unloading ; elasto-visco-plastic strain ; irrecoverable strain ; tertiary creep stage ; nonlinear creep damage model ; high-altitude slope ; BP neural network ; freeze-thaw cycle ; geological conditions ; mining method ; soft broken complex ore body ; improved AHP ; comprehensive evaluation index ; blasting ; back-break ; SVM ; metaheuristic algorithms ; moth–flame optimization ; whale optimization algorithm ; tilted strata ; roadway ; nonuniform deformation ; physical simulation ; HFDEM ; numerical method ; rock fracture ; strain rate ; mining engineering ; backfill mining ; high-concentration backfill ; elastic modulus ; K-fold cross-validation ; mining ; rock engineering ; sensitivity analysis ; XGBoost ; limit equilibrium method (LEM) ; limit analysis ; accuracy ; slope stability ; homogenous slopes ; error accuracy classification chart ; physical and mechanical responses ; Egyptian granodiorite ; thermal damage threshold ; microstructure ; thermal constructions ; rock slope analysis ; limited analysis method ; numerical methods ; combined/hybrid finite–discrete element method ; FDEM ; non-renewable ; clean coal technology ; waste of resources ; “110 construction method” ; collapse settlement control ; moisture content ; dry–wet cycles ; cyclic loading ; injury mechanism ; acoustic emission RA-AF ; thermal effect prediction model ; uniaxial compressive strength ; static Young’s modulus ; artificial neural network ; multilinear regression ; rock mass ; hydraulic conductivity ; sustainability ; rock mechanics ; geotechnical engineering ; geomechanical engineering ; mining technology ; natural stones ; temperature ; fire ; thermal effect ; point load strength ; porosity ; color ; gloss ; automated mineral identification ; LBP ; classification ; texture feature ; liquefaction potential ; prediction ; Bayesian optimization ; support vector machines ; optimization ; Hoek–Brown criterion ; Mohr failure envelope ; Balmer’s equation ; limit equilibrium analysis ; modified Bishop approach ; active earth pressure ; unsaturated narrow backfill ; interlayer shear stress ; arching effect ; thin-layer element method ; tunnel excavation ; cut blasting method ; LLB method ; uncharged hole ; numerical simulation ; spectrum index ; water content ; hyperspectral information ; V-type firing pattern ; collision fragmentation ; RSA ; ANN ; coupled stress-hydro effect ; uniaxial loading ; infrared radiation ; warning threshold ; non-destructive monitoring ; alteration ; tunnel ; stress field ; deformation field ; plastic zone ; flyrock ; weathering index (WI) ; equilibrium optimizer (EO) ; particle swarm optimization (PSO) ; extreme learning machine (ELM) ; artificial neural network (ANN) ; high-water material ; seawater ; water-cement ratio ; strength ; mining method optimization ; difficult-to-mine complicated orebody ; multiple attribute decision making ; Pythagorean fuzzy sets and TOPSIS method ; mechanized upward horizontal layering method ; plateau alluvial-lacustrine deposits ; round gravelly soil ; large scale direct shear test ; shear strength parameters ; Erbil ; geotechnical characterization ; GIS ; ANFIS ; differential evolution ; firefly algorithm ; frozen rock mass blasting ; ice-filled crack ; explosion stress wave propagation ; attenuation factor ; UCS ; intelligent and statistical methods ; sedimentary rocks ; modulus of deformation ; RMR ; in situ testing ; modelling ; instrumentation ; failure risk ; element failure probability ; spatial variability ; stochastic groundwater level ; upper bound method ; rock joints ; shear strength ; scale effects ; normal stress ; JRC ; PFC simulation ; water inrush ; precursor ; strain energy ; normalized ; sustainable mine ; blast-induced flyrock ; LSSVM ; prediction models ; salt cavern ; underground gas storage ; continuum-discrete coupled method ; thermal-mechanical coupling ; thermal damage ; marble strength ; direct and indirect methods ; correlations analysis ; artificial intelligence techniques ; performance indicators ; resonant column test ; torsional simple shear test ; damping ratio ; steady-state vibration ; free vibration decay ; bibliometric analysis ; pile foundation ; sustainable structure ; VOS viewer ; Web of Science ; red clay ; desiccation cracking mechanism ; digital image correlation technology ; strain ; displacement ; mineral carbonation ; comminution energy ; stress–strain relationship ; elastic properties ; radial distribution function ; crown deformation ; underground caverns ; parametric study ; multiple linear regression ; twin tunnels ; 3D numerical analysis ; surface settlement ; field measurement ; geotechnical and geological conditions ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Recent years have seen growing interest in equine lung and heart health, and advances in technology and a focus on equine welfare have driven this research. This Special Issue explores novel diagnostic and therapeutic approaches, including imaging techniques and lung function testing, immunological features, and immunomodulatory treatments for equine asthma and common racehorse respiratory issues. Moreover, it reports on novel echocardiography data of donkeys. This collection offers valuable insights into equine cardio-respiratory medicine.
    Keywords: equine asthma ; exercise-induced pulmonary hemorrhage ; racehorse respiratory medicine ; donkey cardiology ; bic Book Industry Communication::M Medicine
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue focuses on treating the associated comorbidities and complications of cerebral palsy. Increased prescription of technology means that we are treating some comorbidities of cerebral palsy earlier or even pre-emptively. Increased life expectancy, compared with 20 years ago, means that we are also seeing even later complications of cerebral palsy. However, increased access to intensive medical care at home, non-invasive ventilation, and total parenteral nutrition now exist. There is also greater engagement with the perspectives and expectations of parents/carers and children. As society begins to discuss mental health more openly, we are also starting to recognise the significant two-way associations between disability and mental health. Ethical consultation may be warranted when harm with treatment exceeds the benefit. As we prepare children with cerebral palsy for adulthood, there is more thought and discussion around issues such as pain, mental health, quality of life, independence, and participation. Researchers in the field of cerebral palsy have contributed original articles and reviews which help build our evidence base to guide shared decision making.
    Keywords: mental health ; anxiety ; depression ; cerebral palsy ; adolescence ; young adults ; young people ; adolescents ; unmet need ; health services ; physical therapy ; occupational therapy ; fracture ; bone fragility ; mortality ; epidemiology ; age-adjusted mortality rates ; death certificate ; medical education ; severe neurological impairment ; scoliosis ; shared decision-making ; respiratory ; hospitalisations ; antibiotics ; Indigenous ; inequities ; cell therapies ; stem cells ; comorbidities ; outcome measures ; clinical studies ; inflammation ; biomarker ; comorbidity ; scoping review ; co-design ; intervention ; participation ; involvement matrix ; public and patient involvement ; early intervention ; infant vocalisations ; infants ; single-subject research design ; CP ; infant ; stress ; parents ; fathers ; parent–infant interaction ; representations ; epilepsy ; children ; neuroimaging ; seizure outcome ; Sialorrhea ; submandibular duct relocation ; postoperative management ; ultrasound ; piecewise model ; muscle volume ; cross-sectional area ; GMFCS ; upper limb ; sensory function ; bimanual intensive functional therapy ; hand function ; associated impairment ; register ; low- and middle-income country ; hip displacement ; hip surveillance ; adductor-psoas release ; hip reconstruction ; guided growth ; salvage surgery ; disability ; emotion regulation ; atropine ; sialorrhea ; pediatric ; drooling ; sublingual ; developmental disorders ; neurodevelopmental disorders ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint entails descriptions of novel issues and challenges for primary mental healthcare regarding both general and vulnerable populations on a global scale. It is intended for health professionals and all who are interested in mental health care at the primary level.
    Keywords: depression ; sense of coherence ; burnout ; COVID-19 ; nurses ; medication adherence ; mental health nurses ; tacit knowledge ; schizophrenia ; sensory processing sensitivity ; environmental sensitivity ; university students ; nursing ; scale ; somatization ; number of diseases ; coping strategies ; sex ; aggression ; alexithymia ; comprehensibility ; quality of life ; family caregivers ; students ; medical ; psychological problem ; undergraduate ; Saudi Arabia ; n/a ; prospect theory ; applied psychology ; health ; decision making ; behavior ; prevention ; multiple sclerosis ; Beck depression inventory ; anxiety ; fatigue ; mediation ; lawyers ; suicidal ideation ; occupational stress ; loneliness ; perceived stress ; mental health ; work overcommitment ; mental health care ; adolescence ; internalizing/externalizing problems ; social skills ; neurodevelopmental disorders ; filmmaking intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint includes studies on diagnosing, evaluating and managing the pathologies diagnosed during pregnancy. The information provided in these pages is helpful for specialists in obstetrics and gynaecology but also for other medical specialities involved in treating pregnant women with associated pathologies. Studying the articles in the reprint could contribute to improving case management.
    Keywords: pregnancy ; fetus prenatal care ; high-risk ; pathology ; bic Book Industry Communication::M Medicine
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The aim of this Special Issue is to specify relevant principles of mathematics and mechanics in order to explore and understand biological problems. We summarize the most important parameters that influence human performance and that are related to the health sciences for all age groups, throughout their lives. We present papers that aim to introduce the latest research in the fields of health, quality-of-life improvement, and sport rehabilitation and that summarize their recommendations for best practice. The aim for this Special Issue is, therefore, to effectively combine and coordinate research and results in order to understand and improve human movement in medicine, sports, and at work.
    Keywords: tendinopathy ; Achilles tendon ; hyaluronic acid ; viscoelastic properties ; isometric contraction ; matrix metalloproteinase 3 ; interleukin-1beta ; fascia ; chronic low back pain ; myofascial release ; quality of life ; older adults ; oldest-old ; measurement invariance ; SHARE European Survey ; therapeutic exercises ; chronic neck pain ; scapular dyskinesia ; DOMS ; vibration ; post-exercise muscle damage ; physical exercise ; recovery ; women’s rugby ; anthropometry ; body composition ; adiposity ; somatotype ; lower-body strength ; accelerometry ; falls ; squat jump ; syndesmosis ; anterior inferior tibiofibular ligament ; high ankle sprain ; rotational instability ; posterior malleolus ; stabilization ; anatomic repair ; syndesmotic screw ; suture-button ; internal bracing ; treatment algorithm ; cardiac rehabilitation ; peripheral artery disease ; COVID-19 ; intermittent claudication ; review ; pressotherapy ; compression ; regeneration ; return-to-play ; rotator cuff repair ; shoulder injuries ; shoulder surgery ; shoulder assessment ; chronic obstructive pulmonary disease ; COPD ; acupuncture ; acupuncture therapy ; acupuncture treatment ; health-related quality of life ; anterior knee laxity ; stiffness ; general joint laxity ; genu recurvatum ; low back pain ; physical activity ; trunk alignment ; rasterstereographic system ; young males ; tissue flossing ; floss band ; vascular occlusion ; muscle strength ; muscle endurance ; warm-up ; TECAR therapy ; high-intensity laser therapy ; manual therapy ; muscle disorders ; hemophilia ; knee ; virtual reality exposure therapy ; joint pain ; physiotherapy ; daily physical function ; middle-aged and older adults ; CHARLS ; aging ; appendicular muscle mass ; inflammaging ; biomarkers ; adiponectin ; sarcopenia ; bic Book Industry Communication::M Medicine
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The 3D analysis of human movement aims to objectively and quantitatively assess motor functions and alterations. It is a valuable method for sport scientists, coaches, and clinicians to evaluate sport performance, common movements, and alterations. The feasibility of 3D analysis is increasing because it can be adopted both in a laboratory setting or directly in the field, in static or dynamic conditions, and for physiological or pathological movements. This evaluation technique can be adopted for many people, including children, adolescents, adults, and older people, whether they are sedentary or athletes and whether they are healthy or motor-impaired people.
    Keywords: virtual reality ; augmented reality ; lifelogging ; mirror world ; health ; posture training ; feedback ; COVID-19 ; neck-shoulder-region ; shoulder protraction ; upper crossed syndrome ; posture weakness ; physical inactivity ; sedentary behavior ; soccer ; climbing ; exhaustion ; fatigue ; training ; machine learning ; sports ; gender ; data mining ; artificial intelligence ; posture ; reproducibility ; mobile app ; movement ; kinesiology ; sport performance ; inertial sensor ; inertial sensor device ; inertial measurement unit ; training load ; external load ; physical demand ; handstand ; postural control ; postural balance ; sEMG ; stabilometric assessment ; exercise ; Nordic walking ; walking ; 3D kinematics ; biomechanics ; gait analysis ; kyphosis ; spinal mouse ; photogrammetry ; postural evaluation ; bicycle ; cyclists ; saddle pressure ; perineal pressure ; urogenital system ; injury prevention ; cervical ROM ; elastic taping ; neck pain ; musculoskeletal health ; n/a ; bic Book Industry Communication::M Medicine
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In the orthopedic surgical field, knee surgeries, including articular cartilage repair procedures, meniscus surgery, ligament reconstruction surgery, osteotomy surgery, and partial/total knee arthroplasty surgery, have made great advances over the last few decades. This Special Issue highlights and focuses on the surgical concepts and techniques, decision-making processes, perioperative management protocols, and clinical outcomes of the recent various advanced knee surgery procedures.
    Keywords: high tibial osteotomy ; TomoFix ; plate position ; anatomical conformity ; dual-energy CT ; Hounsfield unit ; bone mineral density ; volumetric phantomless BMD ; opportunistic CT ; orthopedic surgeon ; planning ; survey ; total knee arthroplasty ; unicompartmental knee arthroplasty ; anterior cruciate ligament ; reconstruction ; bone tunnel widening ; adjustable-loop device ; interference screw ; hamstring tendon ; autograft ; tibial component alignment ; radiographic references ; extramedullary system ; tranexamic acid ; clamping time ; transfusion ; estimated blood loss ; continuous cold flow therapy ; cryotherapy ; pain ; opioids consumption ; patient satisfaction ; bone marrow lesion ; knee ; meniscus ; root tear ; root repair ; femorotibial joint ; chondromalacia ; aging ; body mass index ; magnetic resonance imaging ; automated detection ; detection algorithm ; deep learning ; venous thromboembolism ; medial collateral ligament ; strain ; video extensometer ; medial opening-wedge high tibial osteotomy ; central sensitization ; patient-reported outcomes ; osteotomy site pain ; minimal clinically important difference ; human umbilical cord blood derived mesenchymal stem cells ; cartilage regeneration ; cartilage repair ; osteoarthritis treatment ; stem cell therapy ; Outerbridge ; degeneration ; spacer block ; intramedullary rod ; femorotibial congruence ; unicompartmental arthroplasty ; osteoarthritis ; cartilage ; stem cells ; umbilical cord blood ; femur fracture ; polyethylene insert ; osteoporosis ; multivariate logistic analysis ; atelocollagen ; microfracture ; ACIC ; bone marrow aspirate concentrate ; human umbilical cord blood-derived mesenchymal stem cells ; knee osteoarthritis ; loosening ; arthroplasty ; machine learning ; transfer learning ; review ; prosthesis ; meniscus root ; medial meniscus posterior root ; medial meniscus posterior root tear ; meniscus root repair ; transtibial pull-out repair ; bone tunnel enlargement ; anterior cruciate ligament reconstruction ; landmark ; lateral tibial spine ; anatomy ; bic Book Industry Communication::M Medicine
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Over the years, digestive endoscopy has gone through a revolution. With different technological improvements, its diagnostic role is indeed becoming more and more sophisticated and is even moving closer to pathological evaluation. Above all, its therapeutic purpose is to date the first line of treatment for several gastrointestinal diseases. Importantly, the role of digestive endoscopy is also crossing over the mere concept of the GI tract and digestive diseases and will probably find a place in a more holistic concept of health. In this Special Issue, several emerging techniques are addressed, highlighting how endoscopy is emerging as a minimally invasive treatment procedure for several gastrointestinal diseases and post-surgical complications. However, crucial to this is the safety of all endoscopic processes, starting from endoscopic suites to the management of intra- and post-procedural complications.
    Keywords: interventional endoscopy, ERCP, cholangioscopy, biliopancreatic endoscopy, CH-EUS, radiofrequency ablation, necrosectomy, locoregional treatment, bariatric endoscopy, artificial intelligence ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: A high demand for metals (cobalt, copper, gold, lithium, nickel, tin, vanadium, etc.) has been recorded for the past several decades, and this demand is expected to increase even further in the coming decades as the world moves to low-carbon technologies based on renewable energy sources (RESs) and electric vehicles (EVs) and away from the heavy use of fossil fuels. To meet the high forecasted demand, unconventional sources of metals such as low-grade complex ores, seafloor massive sulfides (SMSs), and wastes (e.g., tailings, metallurgical residues, and electronic wastes (e-wastes)) have become very important sources of metals; moreover, these metals should be extracted in a sustainable manner without negatively impacting the environment. This Special Issue focused on recent advances in the sustainable production of metals from the above-mentioned unconventional sources.This reprint is a compilation of a Special Issue of Minerals, “Sustainable Production of Metals for Low-Carbon Technologies”, where 13 papers contributed by experts in the area were published. Papers published in this Reprint cover a wide range of topics, including mineral processing (gravity concentration, magnetic separation, and flotation), hydrometallurgical techniques (leaching, solvent extraction, and cementation) to extract minerals/metals from primary and secondary resources. All the papers are of high scientific value and will be of great interest to readers of Minerals.
    Keywords: flotation circuit ; gold ore ; diagnosis ; optimization ; mass balance ; process simulation ; printed circuit boards ; heat treatment ; strength ; liberation ; Cu recovery ; physical separation ; ferronickel slag ; sulfuric acid leaching ; light magnesium oxide ; rare earth elements ; magnetic separation ; upgradation ; Khalzan Buregtei deposit ; NiMH batteries ; rare earth metals ; leaching ; solvent extraction ; precipitation ; gold ; cementation ; galvanic interaction ; aluminum ; activated carbon ; kinetics ; ammonium thiosulfate solution ; mass transfer ; fluorine ; occurrence ; removal ; gravity-flotation separation ; lignite ; lead ; zinc ; Al metal powder ; zinc plant leach residues ; flotation ; copper sulfides ; tailings ; carrier flotation ; flocculation ; oil agglomeration ; complex sulfide ores ; sphalerite ; anglesite ; extraction ; lithium ion battery ; recycling ; carbothermic reduction ; graphite ; porphyry copper deposits ; chalcopyrite ; pyrite ; n/a ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TT Other technologies and applied sciences::TTU Mining technology and engineering
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Modern medical imaging systems provide information about the patient's health condition. Their precision, resolution and sensitivity are increasing, and new possibilities of differentiating the condition of tissue are constantly appearing. These advances are also taking place in musculoskeletal imaging. Increasingly accurate imaging in various modalities allows us to discover new relationships between the image and the diagnosis. It is therefore important to use all this information to best serve the patient. That is why research related to the analysis of medical images is so important, because it allows us to indicate what is invisible to the naked eye or to quantify what has so far been measured by humans or subject to discretionary assessment. This collection includes 25 works related to the analysis of images created during diagnostics of the musculoskeletal system using various modalities—from X-ray and fluoroscopy to conventional or spectral computed tomography, magnetic resonance imaging, ultrasound, elastography, PET/CT and systems for analyzing patient mechanics. Research was carried out related to the detection of various conditions, parameterization of clinical and population phenomena, and detection of image–clinical condition relationships. Despite the current popularity of machine learning techniques, the collection is dominated by classic engineering methods related to image processing. Several works use textural analysis, which has not been appreciated so far, which is particularly related to the imaging of the structure, especially of bones.
    Keywords: bone imaging, musculoskeletal imaging, image processing, image analysis, segmentation, textural analysis, machine learning ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Pain biomarkers are biological indicators or measurable characteristics that can provide information about the presence, severity, or underlying mechanisms of pain. They are valuable for several reasons: Diagnosis and differential diagnosis: Biomarkers can help in the diagnosis of various pain conditions and differentiate between different types of pain, such as neuropathic, inflammatory, or nociceptive pain. This can lead to more accurate and timely diagnoses, which in turn can improve patient care. Monitoring treatment efficacy: Pain biomarkers can be used to track how well treatments are working for individuals suffering from chronic pain conditions. This allows healthcare providers to make informed decisions about adjusting treatment plans, optimizing pain management, and avoiding unnecessary or ineffective interventions. Drug development and testing: Biomarkers play a crucial role in the development of new pain medications and therapies. They can help researchers identify potential drug targets, screen compounds for their pain-relieving properties, and assess the safety and efficacy of experimental treatments in clinical trials. Personalized medicine: Pain biomarkers may, in a future, contribute to treatments, tailored to an individual's unique genetic and biological disposition. Reducing opioid misuse: By using biomarkers to assess pain and treatment responses, healthcare providers can make more informed decisions about opioid prescriptions, potentially reducing the overuse and abuse of these medications.
    Keywords: analgesia ; biomarker ; CSF ; cytokine ; inflammation ; neuropathy ; neurotransmitter ; pain ; QoL ; sensitization ; sensory ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue focuses on the comprehensive understanding and novel treatments in the realm of cornea and ocular surface diseases. Ranging from the relatively benign manifestations of keratoconjunctivitis sicca to more critical conditions such as corneal ulcers, ocular surface diseases pose a considerable challenge in clinical ophthalmology. Such conditions can severely compromise the transparency of the cornea, often necessitating interventions such as keratoplasty. A significant emphasis of this edition is on the paramount importance of pre-surgical optimization. A successful keratoplasty is often predicated on the health of the ocular surface. Through a series of insightful articles, the importance of enhancing tear function, rehabilitating the normal lid anatomy, and ensuring a robust limbal stem cell supply is elucidated. Properly addressing these factors has a direct bearing on the success rate of the subsequent surgical intervention. Another highlight of this Special Issue is the presentation of cutting-edge treatments. Researchers from around the globe share their findings, detailing advancements in both surgical and non-surgical treatments. These range from innovative surgical techniques and tools to groundbreaking pharmaceutical agents that hold promise in managing and possibly reversing some of these conditions. In summary, this Special Issue serves as a repository of the latest knowledge in the management of cornea and ocular surface diseases, aimed at both the seasoned ophthalmologist and budding researchers in the field.
    Keywords: cornea ; ocular surface disease ; dry eye ; corneal ulcer ; keratoplasty ; bic Book Industry Communication::M Medicine
    Language: English
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  • 20
    Publication Date: 2024-01-08
    Description: This reprint, entitled “Management of Acute and Chronic Complications of Lysosomal Storage Diseases in Children and Adults: Current Practice and Future Opportunities”, covers broad aspects of this group of rare diseases. The first theme includes articles on the management of pain, corneal clouding, gastrointestinal and airway diseases in Mucopolysaccharidoses and Mucolipidoses, and the evaluation of dysphonia in Pompe disease. Additionally, attention deficit and ADHD and the management of atherosclerosis in Fabry disease are considered here. The second theme includes diagnostic conundrums in lysosomal storage diseases, e.g., the prenatal diagnosis of Gaucher disease during pregnancy, the diagnosis of secondary hyperparathyroidism in Mucolipidoses, and the application of the new biomarker “plasma neurofilament light” in Niemann Pick C disease, as well as the correlation of enzyme activity with molecular diagnosis in Pompe disease. The articles in the third theme describe the impact of therapies on clinical outcomes. For example, a systematic review of the impact of enzyme replacement therapy on late-onset Pompe disease and trehalose use on Niemann Pick A and B is included. The remaining articles describe the NHS processes for overcoming challenges resulting from the COVID-19 pandemic and the differences in the transition from paediatric to adult services between different countries.
    Keywords: Mucopolysaccharidosis ; corneal clouding ; penetrating keratoplasty ; deep anterior lamellar keratoplasty ; mucopolysaccharidoses ; airway ; obstruction ; management ; Fabry disease ; attention ; Attention Deficit/Hyperactivity ; cognition ; late-onset Pompe disease ; gastrointestinal ; smooth muscles ; PROMIS–GI symptom scales ; GAAKO mice ; glycogen storage disorder ; translational research ; patient-reported outcomes measures ; mucopolysaccharidosis ; MPS ; disease manifestations ; symptoms ; morbidity ; spine disease ; anaesthesia ; perioperative complications ; surgery ; pompe disease ; speech ; voice ; dysphonia ; acoustic ; auditory-perceptual ; GRBAS ; respiratory ; Pompe disease ; gene panel sequencing ; alpha-glucosidase ; GAA ; dried-blood spots ; fabry disease ; neuropathic pain ; depression ; Fabry ; atherosclerosis ; ischaemia ; perfusion ; angina ; Sanfilippo syndrome ; mortality ; Niemann–Pick C ; neurofilament light ; biomarkers ; neurological disease ; glycogen storage disease type II ; enzyme replacement therapy ; COVID-19 ; inherited metabolic disorders ; rare autoinflammatory diseases ; health care providers ; Gaucher disease ; NIHF ; perinatal-lethal Gaucher disease ; PLGD ; ichthyosis ; GBA gene ; airway management ; radiology ; hyoid bone ; chin ; intubation ; intratracheal ; lysosomal storage disease (LSD) ; Niemann–Pick type A ; Niemann–Pick type B ; acid sphingomyelinase ; sphingolipid deposition ; trehalose ; mucolipidosis type II ; ML II ; I-cell disease ; hyperparathyroidism ; mucolipidosis ; ML ; MLII ; transition service ; adult metabolic medicine ; collaboration ; challenges ; inherited metabolic diseases ; healthcare systems ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Molecular toxicology is a field that investigates the interactions between chemical or biological molecules and organisms at the molecular level. In this Special Issue, we focus on the toxic effects and mechanisms of action of chemical and biological molecules, will be of great interest of readers in molecular toxicology and applied pharmacology.
    Keywords: smoking ; inflammatory ; cytokine ; human serum ; GO ; PRRSV ; FT-SPR ; sensitization ; NNK ; nicotine ; cytotoxicity ; genotoxicity ; cytochrome P450 2A13 ; Aspergillus flavus ; aflatoxins B1 ; carcinogen ; Surface-Enhanced Raman Scattering ; colloidal Au nanoparticles ; portable Raman spectrometer ; Euphorbia semen ; Euphorbia factors ; transcriptome ; RNA sequencing ; bioinformatics ; gene structure ; neuroblast differentiation-associated protein AHNAK ; hepatocellular carcinoma (HCC) ; insulin-like growth factor 1 receptor (IGF-1R) ; interactome ; field cancerization ; 8–17 DNAzyme ; gene silencing ; catalysis ; antisense ; chemical modifications ; 6-cyclohexyl methyl-β-D-maltoside ; transduction efficiency ; conditionally replicative adenovirus ; lethal effect ; gene therapy ; PBDE ; immunotoxicity ; macrophage ; reactive oxygen species ; apoptosis ; immune function ; breast cancer ; signature ; aging ; cancer ; nomogram ; immunotherapy ; tumor mutation burden ; doxorubicin ; Toll-like receptor 4 ; cardiotoxicity ; heart ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Language: English
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint aims to identify critical areas of water quality assessment, modeling, and mitigation in freshwater bodies, wastewater treatment, and groundwater aquifers, which require special attention. This links the volume to multiple regulatory options, including policy and governance measures, alternative ecosystem service dependence options (i.e., nature-based solutions), or mechanisms that link regions to international processes, like measures proposed under the Environmental Protection guidelines. The reprint will pay special attention to water quality assessment, modeling, and mitigation.
    Keywords: pumping station pipeline ; chaotic characteristic ; IVMD ; vibration response ; correlation dimension ; Lyapunov exponent ; monitoring ; mitigations ; spatial and temporal variabilities ; principal component analysis ; cluster analysis ; discriminant analysis ; water quality ; pollution ; correlation ; settlement ; damage evolution ; seepage/stress-damage method ; data monitoring ; groundwater ; heavy metals ; physicochemical parameters ; in-situ ; machine learning ; geostatistical analysis ; nanofiltration ; electrocoagulation ; nickel ; zinc ; copper ; water pollution ; adsorption ; copper ions ; adsorption mechanism ; adsorption kinetics ; thermodynamics ; expanded S-curve model ; domestic water usage ; economic development ; mathematical model ; Sentinel-2 ; chlorophyll ; turbidity ; lake ; concentration modeling of contaminants ; Cuernavaca aquifer ; hydrochemistry ; water quality index ; time series analysis ; spatial analysis ; water intensity ; LMDI model ; Tapio model ; technical effect ; industrial structure effect ; regional scale effect ; tannery effluent ; ozonation ; optimization ; turbidity removal ; Taguchi ; ecosystem services ; provisioning ecosystem services ; regulating ecosystem services ; cultural ecosystem services ; supporting ecosystem services ; modeling ; water quality indexing ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The reprint, titled ”Sustainable Biopolymer-Based Composites: Processing, Characterization, and Application”, is composed of 32 scientific works of scholars that contributed their own expertise passion, and science to expand the boundaries of knowledge by addressing new challenges. The topic of new biopolymer-based composite materials is addressed from several aspects, from the development to characterization and application, in several fields of scientific interest.
    Keywords: biopolymer-treated soil ; Xanthan Gum ; Guar Gum ; soil strength ; durability ; cyclic wetting-drying ; biodegradability ; carbon nanotubes ; graphene ; life cycle analysis ; nanocomposites ; packaging ; remediation ; starch ; aging ; coarse wool fibre ; hybrid composites ; natural rubber ; PALF ; sisal fibre ; mulch films ; biopolymers ; SDGs ; plastic pollution ; polymers ; microfluidics ; lab-on-chip ; biomedical engineering ; drug carrier ; artificial cell ; 3D bioprinting ; hydrogel films ; gelatin ; antimicrobial activity ; food packaging ; TGA ; biocomposites ; renewable sources ; wood waste ; waste valorization ; primerless-wet bonding ; resin adhesive system ; hybrid layer ; tensile bond strength ; micro-seal ; luting resin ; dental prosthesis ; fixed prosthodontics ; bioplastics ; conventional polymers ; renewable resources ; LCA ; fish collagen ; fish industry waste ; collagen extraction ; nano collagen ; sustainability ; poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) ; cellulose nanofiber ; bionanocomposite ; melt-extrusion processing ; optimization ; response surface methodology ; acrylonitrile butadiene rubber ; fish scale ; bis(triethoxysilylpropyl)tetrasulfide ; composite ; compatibilizer ; collagen biopolymer ; unicornfish bone ; acid extraction ; characterization ; biocompatible ; biodegradable ; scaffolds ; tissue engineering ; lignin biopolymer ; erosion ; triaxial test ; wetting and drying cycles ; silt ; green macroalga ; red sea ; Chaetomorpha linum ; cellulose nanocrystals ; green silver nanoparticles ; bio-nanocomposite films ; optical properties ; Torenia fournieri ; zinc oxide nanoparticle ; smart packaging sensors ; wound healing ; biodegradable plastic ; circular economy ; pineapple ; tensile strength ; silver nanoparticles ; green synthesis ; Piper betle L. leaf ; pig lining leather ; antibacterial activity ; antifungal activity ; polylactic acid (PLA) ; spent coffee grounds (SCG) ; rheological properties ; mechanical properties ; chitosan ; nanofiber ; preparation ; applications ; wound dressing ; acetylation ; flour ; physicochemical properties ; modification ; wound dressings ; hydrogel ; honey ; natural polymer ; synthetic polymer ; PLA ; biodegradation ; sports equipment manufacturing ; arrowroot starch ; heat-moisture treatment ; octenylsuccinilation ; dual-modification ; functional properties ; glabridin ; 3-O-Ethyl-L-ascorbic acid ; tranexamic acid ; microneedles ; pigmentation ; multifunctional drug ; hydrophilic bioplastics ; gum Arabic ; polyvinyl alcohol ; casting of poly-(methyl methacrylate) ; dehydration ; phosphorus pentoxide ; peeling ; microbial biodegradation ; green composites ; stem fiber ; crystallinity ; thermal behavior ; reinforcement material ; pineapple leaf fiber ; flax ; poly(butylene succinate) ; unidirectional composites ; microstructure ; sustainable materials ; epoxy resin ; Schiff base ; epoxidized soybean oil ; epoxy vitrimer ; reprocessability ; recyclability ; agroindustrial wastes ; biomaterials ; cellulose ; lignocellulosic biomass ; polylactic acid ; coir fiber ; bamboo leaf fiber ; annealing ; biocomposite ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TD Industrial chemistry and manufacturing technologies::TDC Industrial chemistry and chemical engineering
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: In this Special Issue, we have gathered high-level research papers from all over the world. We would like to thank all researchers for their commitment to the field. From diagnostic ultrasound of different fetal conditions to advanced cardiovascular imaging leading to fetal MRI and from serum markers and biomarkers in maternal and fetal conditions to new modalities in fetal therapy, this Special Issue covers a large scale view of the present spectrum of modern perinatal medicine. Again, a warm thank you to all contributors.
    Keywords: fetal echocardiography ; fetal abnormalities ; fetal therapy ; genetic testing, prenatal medicine ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The topics covered in this Special Issue range from breastfeeding and early-life nutrition to effects on microbiota, infection, allergy, asthma, and the mechanisms of immunomodulation via (the early introduction of) nutrition on infections and the development of (food) allergies.
    Keywords: diet ; pregnancy ; cord blood ; fatty acids ; n-3 PUFAs ; n-6 PUFAs ; arachidonic acid ; phospholipids ; atopic eczema ; NICE birth cohort ; multi-allergen ; early introduction ; food allergy ; safety ; efficacy ; prevention ; allergic sensitization ; foetal immune ontogeny ; gene/environment interactions ; asthma ; eczema ; maternal diet ; PUFAs ; vitamin D ; Mediterranean diet ; microbiome ; breastfeeding ; functional gastrointestinal disorder ; partial hydrolysate ; peptide ; protein ; infancy ; childhood ; immune development ; probiotic ; microbiota ; allergy ; atopic dermatitis ; breastmilk ; house dust mite ; Der p 1 ; Asthma ; total IgE ; atopy ; sensitization ; oral tolerance ; early food introduction ; milk protein ; cow’s milk allergy (CMA) ; maternal atopy ; epigenetics ; pediatric asthma ; cohort study ; immune complex ; trained immunity ; RSV ; bovine IgG ; preF protein ; cow’s milk allergy ; allergen ; hypoallergenic infant formula ; n/a ; IgA deficiency ; selenium deficiency ; zinc deficiency ; recommended dietary allowances ; immune system ; allergen molecules ; milk allergen micro-array ; peptides ; anaphylaxis ; milk tolerance ; diagnosis ; IgE sensitization ; children ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Helicobacter pylori is one of the most common infections in the world, affecting roughly half of all humans. Although it is not an infection that causes death immediately after infection, it is one of the largest emerging infectious diseases in the history of humankind, causing a wide variety of diseases and, in the long term, serious complications such as stomach cancer. This Reprint contains empirical studies and reviews regarding the diagnosis, treatment, complications, and management of H. pylori infection, including new diagnostic methods, effective eradication regimens, the management of gastric cancer, and other topics.
    Keywords: gastric cancer ; biliopancreatic reflux ; gastritis ; carcinoma ; endoscopic surveillance ; Helicobacter pylori infection ; gastric stump cancer ; Helicobacter pylori ; H. pylori ; rifabutin ; treatment ; eradication failure ; culture ; bismuth ; rescue ; Hp-EuReg ; third-generation ultrathin endoscope ; transnasal endoscopy ; narrow-band imaging ; Kyoto classification of gastritis ; gastric atrophy and intestinal metaplasia ; diagnosis ; stool antigen test ; urea breath test ; peptic ulcer disease ; triple therapy ; vonoprazan ; dyspepsia ; Kyoto Classification of Gastritis ; cagA ; Okinawa ; endoscopic findings ; Helicobacter infection ; tetracycline ; eradication ; penicillin allergy ; furazolidone ; metronidazole ; amoxicillin ; child ; host genetic factor ; iron deficiency anemia ; iron demand ; iron uptake ; sports activity ; virulence factor ; gastric lymphoma ; MALT lymphoma ; radiotherapy ; chemotherapy ; rituximab ; dual therapy ; vonoprazan (VPZ) ; amoxicillin (AMOX) ; clarithromycin (CAM) ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: The Special Issue entitled “Advances in Rock Mechanics and Geotechnical Engineering” is devoted to the publication of the latest research, field works, and laboratory investigations in the area of rock mechanics and geotechnical engineering. This Special Issue has published novel contributions in different areas of geotechnical and geomechanical engineering such as slope and embankment, tunneling and underground space technologies, pile and foundation, rock mechanics and rock blasting, excavation and leveling projects, ground improvement techniques, unsaturated soil, practical issues in soft soil, mining technology, geo-environmental engineering, new laboratory testing, applied geology for construction, and novel geotechnical construction methods. The focus of this reprint is on the development of computational methods for solving problems in the fields of rock mechanics and geotechnical engineering.
    Keywords: strength prediction ; brittle rock ; grain-structure representation ; micro-properties ; bonded block models ; Voronoi tessellation ; structure-type rockburst ; evolution mechanism ; particle flow code ; flat-joint model ; pre-grouting ; soft coal mass ; coal-grout structure ; shear behavior ; quality improvement ; rock strength ; tensile behaviour ; neuro-fuzzy ; regression ; non-destructive tests ; paste filling ; slicing mining ; false roof stability ; optimal false roof thickness ; tree-based techniques ; feature selection ; pile bearing capacity ; gradient boosted tree ; random forest ; in situ stress ; rock blasting ; crack propagation ; model test ; rheological deformation ; key stratum ; roadway groups ; roadway deformation ; surrounding rock control ; triaxial creep experiment ; cyclic loading and unloading ; elasto-visco-plastic strain ; irrecoverable strain ; tertiary creep stage ; nonlinear creep damage model ; high-altitude slope ; BP neural network ; freeze-thaw cycle ; geological conditions ; mining method ; soft broken complex ore body ; improved AHP ; comprehensive evaluation index ; blasting ; back-break ; SVM ; metaheuristic algorithms ; moth–flame optimization ; whale optimization algorithm ; tilted strata ; roadway ; nonuniform deformation ; physical simulation ; HFDEM ; numerical method ; rock fracture ; strain rate ; mining engineering ; backfill mining ; high-concentration backfill ; elastic modulus ; K-fold cross-validation ; mining ; rock engineering ; sensitivity analysis ; XGBoost ; limit equilibrium method (LEM) ; limit analysis ; accuracy ; slope stability ; homogenous slopes ; error accuracy classification chart ; physical and mechanical responses ; Egyptian granodiorite ; thermal damage threshold ; microstructure ; thermal constructions ; rock slope analysis ; limited analysis method ; numerical methods ; combined/hybrid finite–discrete element method ; FDEM ; non-renewable ; clean coal technology ; waste of resources ; “110 construction method” ; collapse settlement control ; moisture content ; dry–wet cycles ; cyclic loading ; injury mechanism ; acoustic emission RA-AF ; thermal effect prediction model ; uniaxial compressive strength ; static Young’s modulus ; artificial neural network ; multilinear regression ; rock mass ; hydraulic conductivity ; sustainability ; rock mechanics ; geotechnical engineering ; geomechanical engineering ; mining technology ; natural stones ; temperature ; fire ; thermal effect ; point load strength ; porosity ; color ; gloss ; automated mineral identification ; LBP ; classification ; texture feature ; liquefaction potential ; prediction ; Bayesian optimization ; support vector machines ; optimization ; Hoek–Brown criterion ; Mohr failure envelope ; Balmer’s equation ; limit equilibrium analysis ; modified Bishop approach ; active earth pressure ; unsaturated narrow backfill ; interlayer shear stress ; arching effect ; thin-layer element method ; tunnel excavation ; cut blasting method ; LLB method ; uncharged hole ; numerical simulation ; spectrum index ; water content ; hyperspectral information ; V-type firing pattern ; collision fragmentation ; RSA ; ANN ; coupled stress-hydro effect ; uniaxial loading ; infrared radiation ; warning threshold ; non-destructive monitoring ; alteration ; tunnel ; stress field ; deformation field ; plastic zone ; flyrock ; weathering index (WI) ; equilibrium optimizer (EO) ; particle swarm optimization (PSO) ; extreme learning machine (ELM) ; artificial neural network (ANN) ; high-water material ; seawater ; water-cement ratio ; strength ; mining method optimization ; difficult-to-mine complicated orebody ; multiple attribute decision making ; Pythagorean fuzzy sets and TOPSIS method ; mechanized upward horizontal layering method ; plateau alluvial-lacustrine deposits ; round gravelly soil ; large scale direct shear test ; shear strength parameters ; Erbil ; geotechnical characterization ; GIS ; ANFIS ; differential evolution ; firefly algorithm ; frozen rock mass blasting ; ice-filled crack ; explosion stress wave propagation ; attenuation factor ; UCS ; intelligent and statistical methods ; sedimentary rocks ; modulus of deformation ; RMR ; in situ testing ; modelling ; instrumentation ; failure risk ; element failure probability ; spatial variability ; stochastic groundwater level ; upper bound method ; rock joints ; shear strength ; scale effects ; normal stress ; JRC ; PFC simulation ; water inrush ; precursor ; strain energy ; normalized ; sustainable mine ; blast-induced flyrock ; LSSVM ; prediction models ; salt cavern ; underground gas storage ; continuum-discrete coupled method ; thermal-mechanical coupling ; thermal damage ; marble strength ; direct and indirect methods ; correlations analysis ; artificial intelligence techniques ; performance indicators ; resonant column test ; torsional simple shear test ; damping ratio ; steady-state vibration ; free vibration decay ; bibliometric analysis ; pile foundation ; sustainable structure ; VOS viewer ; Web of Science ; red clay ; desiccation cracking mechanism ; digital image correlation technology ; strain ; displacement ; mineral carbonation ; comminution energy ; stress–strain relationship ; elastic properties ; radial distribution function ; crown deformation ; underground caverns ; parametric study ; multiple linear regression ; twin tunnels ; 3D numerical analysis ; surface settlement ; field measurement ; geotechnical and geological conditions ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This reprint focuses on the importance of the micronutrient iron in human physiological iron homeostasis and iron-related diseases. Daily adequate dietary iron supply ensures vital body functions and hemoglobin synthesis during erythropoiesis. During the last few decades, scientific evidence has shown that the maintenance of human iron homeostasis is an important factor for physical and mental health. The present reprint gives an overview of how iron, as an essential dietary element, is responsible for physiological and pathological biochemical processes in the human body. For the readership, this relevant information will provide an evidence-based update on the complex regulatory mechanisms and related diseases of iron metabolism.
    Keywords: iron metabolism ; iron homeostasis ; micronutrient iron ; physiology ; pathology ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 29
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Biomaterials are natural or artificial materials used to manufacture implants to replace lost or diseased biological structures in order to restore form and function. Biomaterials that require long-term service, such as orthopedic implants, need good physical and chemical stability, such as stainless steel and titanium alloys. The application of metal in biomedicine is becoming more and more common, but due to its various limitations, it is often necessary to modify its surface to obtain better performance and better clinical application. There are many technologies for the surface modification of medical metals, such as laser surface modification, chemical treatment, plasma surface modification, etc., and these technologies are still being developed to meet market demand. This reprint will provide important contributions related to the announced topics, focusing on biomedical metals and the surface modification technologies of biomedical metals.
    Keywords: titanium ; surface modification ; surface topographies ; multifunctional surfaces ; metamaterials ; 4D printing ; ZK60 magnesium ; micro-arc oxidation ; atmospheric plasma spraying ; corrosion ; additive manufacturing ; porous titanium ; implant coatings ; antibacterial agent ; laser cladding ; Ca/P bio-ceramic coating ; biocompatibility ; bioactivity ; wear resistance ; magnetite ; conversion coating ; optimization ; invitro cytotoxicity ; beta titanium alloy ; elastic modulus ; corrosion property ; osseointegration ; Ti-matrix composites (TMCs) ; graphene oxide (GO) ; mechanical properties ; reinforcement ; laser-induced periodic surface structures ; femtosecond laser processing ; functional surfaces ; application ; composite ; 3D printing ; bioresorbable Fe-Cu-hydroxyapatite composite ; titanium alloy ; phosphate layer ; biomaterial ; zinc phosphate ; scholzite ; PVA films ; boric acid ; polyhexamethylene guanidine hydrochloride ; antimicrobial properties ; surface treatment ; titanium alloys ; microstructure ; physicochemical properties ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PH Physics
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  • 30
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: This Special Issue addresses recent advances in the research of plant-derived natural products, their mechanisms of action and how they can influence health and disease. Plant-derived natural products have been well known since antiquity due to their beneficial effects on human health, and since then, they have attracted the interest of the scientific community, leading to the identification, isolation and quantification of their compounds and research on their biomedical properties. They have been found to be rich in phytochemicals, such as terpenes and phenolic compounds, with proven antioxidant, anti-inflammatory, antimicrobial, antitumor and prebiotic properties, and therefore, they have been suggested as potential candidates for the therapeutic management of several chronic diseases. Some of them include inflammatory bowel disease, diabetes, non-alcoholic fatty liver disease, arthritis and cancer, in which inflammation, oxidative stress and dysbiosis mechanisms are implicated. Furthermore, given the increased economic burden, the side effects and the low compliance rates of patients who receive standard medical treatments, plant-derived natural products could possibly serve as adjunct therapeutic agents for chronic diseases.
    Keywords: plants ; natural products ; free radicals ; inflammation ; medicinal ; caffeic acid ; antibacterial ; antifungal ; antioxidant ; anticancer ; juglone ; Juglans regia ; mogrol ; mogroside ; phytochemical ; pharmacology ; osteoporosis ; antiobesity ; anti-inflammation ; neurodegenerative disorders ; anticancer agents ; aromadendrane ; bryophytes ; cytokinesis inhibitor ; Plagiochila species ; plagiochilins ; analgesic activity ; traditional medicine ; wound healing ; colon carcinogenesis ; 1,2 dimethylhydrazine ; hesperetin ; capecitabine ; Jatropha tanjorensis ; Fraxinus micrantha ; HPTLC ; anti-obesity activity ; high-fat diet model ; histological ; Alzheimer ; acetylcholinesterase inhibitors ; Euonymus laxiflorus Champ. ; bioactive compounds ; medicinal plants ; P. lentiscus ; GC/MS ; HPLC-DAD ; antioxidant activity ; antibacterial activity ; antifungal activity ; extract ; molecular docking ; Artemisia arborescens ; Artemisia inculta ; phenolic compounds ; terpenes ; trace metals ; antioxidant capacity ; Eurycoma longifolia Jack ; anti-inflammatory ; antinociceptive effect ; antipyretic effects ; gastroprotective activity ; gastric ulcer ; Thai traditional medicine ; phytochemicals ; inflammatory bowel disease ; gut microbiota ; Mastiha ; Curcumin ; Boswellia serrata ; Artemisia absinthium ; lipidomic profile ; Tulsi ; Ocimum sanctum ; ischemic stroke ; photothrombotic ischemia ; medicinal plant ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Translational research is required to uncover the underlying pathomechanisms of neurological and psychiatric disorders, search for new biomarkers, and develop novel therapeutics. Complex polygenic, multifactorial, and heterogeneous mechanisms have been elucidated using in vivo and in vitro models. Advanced preclinical models have recently revealed an intriguing interaction between sex/gender and aging in the pathogenesis and clinical manifestations of neuropsychiatric disorders. Despite these advances, much work remains to be carried out to fully understand the underlying pathology of these conditions and to develop treatments that can significantly improve the lives of those who suffer from them. The current challenge in the field of neurological and psychiatric disorders is the development of disease-modifying, effective treatments for these complex and long-term debilitating conditions with a high malady burden. The first edition of this research topic, entitled 'Emerging Translational Research in Neurological and Psychiatric Diseases: From In Vitro to In Vivo Models,' emphasizes the importance of translational research in bridging the gap between basic research and clinical applications. Furthermore, it provided a venue for researchers to share their findings and progress in translational research in this field.
    Keywords: Alzheimer&rsquo ; s disease ; Parkinson&rsquo ; multiple sclerosis ; stroke ; migraine ; pain ; depressive disorder ; anxiety disorder ; autism spectrum disorder ; sleep wake disorders ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: undefined
    Keywords: Medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: Various classes of natural and synthetic molecules that can be classified as biomaterials find application in all fields of dentistry. Biomaterials should be biocompatible to minimise toxicity and bioactivity to ensure or simulate biological effects. They are used, for instance, to enhance antibacterial activity and improve the healing process. Calcium silicates, for illustration, are biomaterials used in endodontics that have proven their excellent biological, physico-chemical, and mechanical properties. However, some of these are considered too soluble, and this is almost completely due to their hardness when used as endodontic sealers, making endodontic retreatment very difficult. Despite manufacturers' best efforts, it is sometimes difficult to marry bioactivity, biocompatibility, and clinical benefits in a biomaterial; therefore, in this content, the work of researchers is invaluable.
    Keywords: calcium silicate cement ; retrograde materials ; premixed cement ; powder–liquid cement ; chemical composition ; EDX ; caries prevention ; anterior restorations ; ceramic ; dental veneers ; follow-up ; non-vital teeth ; porcelain laminate veneers ; vital teeth ; antimicrobial ; osseointegration ; surface modification ; tissue engineering ; root canal retreatment ; calcium silicate-based cement ; ProTaper Universal Retreatment ; D-Race ; dentin hypersensitivity ; desensitizing agents ; calcium phosphate ; hydroxyapatite ; nano-hydroxyapatite ; peri-implantitis ; periodontitis ; periapical radiograph ; deep learning ; neural networks ; image enhancement ; carious lesion activity ; irreversible pulpitis ; partial pulpotomy ; vital pulp therapy ; mineral trioxide aggregate ; furcation involvement ; image segmentation ; Gaussian high-pass filtering ; image preprocessing ; CNN ; calcium silicate material ; confocal laser scanning microscope ; deciduous tooth ; digital microscopy ; flowability ; micro-CT ; pulpectomy primary teeth ; root canal filling ; SEM ; zinc oxide eugenol ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-01-08
    Description: The healthcare system’s ability to diagnose and care for people with schizophrenia has improved in recent decades, as effective pharmacological and psychosocial interventions are now available. However, schizophrenia remains a leading cause of disability and premature mortality. The utilization of pharmacological and psychosocial interventions in the healthcare system, which have the potential to significantly improve the quality of life for people with schizophrenia, heavily depends on medical professionals completing accurate and comprehensive assessments of patients’ psychopathologies, cognitive profiles, physical health statuses and any environmental factors that may influence them. This Special Issue reprint on schizophrenia, from the Journal of Clinical Medicine, presents a collection of articles on current approaches to assessment and treatment, as well as new findings and future perspectives of schizophrenia research and care.
    Keywords: schizophrenia ; ERP ; mismatch negativity ; MMN ; P3a ; illness duration ; real-life functioning ; motivation circuits ; negative symptoms ; RDoC ; positive valence system ; salience system ; deficit syndrome ; diagnosis ; cognitive function ; social skills training ; physical comorbidities ; childhood abuse ; internalized stigma ; neutrophil-to-lymphocyte ratio ; antipsychotics ; hypothyroidism ; inflammatory markers ; expressive deficits ; experiential deficits ; functioning ; quality of life ; first psychotic episode ; first episode ; emotional processing ; social cognition ; MCCB ; MSCEIT ; real-world studies ; real-world effectiveness ; tolerability ; treatment adherence ; second-generation antipsychotics ; long-acting injectable antipsychotics ; delusional disorders ; psychosis ; sex ; women ; psychopathology ; construct ; schizophrenia spectrum ; renaming ; rethinking ; revising ; effort expenditure ; recent-onset schizophrenia ; persistent negative symptoms ; motivation ; neuropeptide S ; cognitive functioning ; rehabilitation ; AEP ; QEEG ; switch ; extrapyramidal symptoms ; treatment ; cognitive deficits ; self-evaluation of negative symptoms ; health-related quality of life ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-24
    Description: This book reprints articles from the Special Issue "Advances in Computer-Aided Technology" published online in the open-access journal Machines (ISSN 2075-1702). This book consists of thirteen published articles. This Special Issue belongs to the "Mechatronic and Intelligent Machines" section. Industry 4.0 is characterized by the integration of advanced technologies, such as artificial intelligence, the Internet of Things, and cloud computing, into traditional manufacturing and production processes. CAx (Computer-Aided Systems) systems are a set of computer software tools used in engineering and product design, covering various stages of the product development cycle. Advanced CAx tools combine many different aspects of product lifecycle management (PLM), including design, finite element analysis (FEA), manufacturing, production planning and product. In connection with the transition to Industry 4.0 concepts, the concept of the digital twin comes to the fore, and existing CAx systems must adapt to this trend. The Special Issue deals with a number of research areas, such as: - New trends in CAx systems; Digital manufacturing; Internet of Things in manufacturing; Simulation of production systems and processes; Systems for advanced finite element analysis; Material engineering; Digitization and 3D scanning.
    Keywords: tensor glyph ; golden section ; vector space ; sandwich ; springback ; Vegter yield criterion ; numerical simulation ; PAM-STAMP 2G ; isotropic hardening law ; kinematic hardening law ; bending ; Bauschinger effect ; machine learning ; artificial neural network ; additive manufacturing ; high precision metrology ; CAD ; predictive model ; ship hull structure ; computer-aided design of structure ; database ; function soft block ; gun drill tool ; deep-drilling technology ; optimization ; tool life ; angle ; digital implant impression ; interimplant distance ; intraoral scanner ; trueness ; sewing machine ; needle bar ; floating needle ; electromagnet ; electromagnetic simulation ; noise reduction ; cycloidal gearbox ; friction ; actuator ; servomotor ; permanent magnet synchronous machine ; fixture design ; machining ; sustainable manufacturing ; process innovation ; complex-shape part ; signal processing ; monitoring system ; laser profiler ; surface roughness ; quality assessment ; non-contact method ; vision-based method ; frequency analysis ; abrasive water jet ; wood plastic composite ; natural reinforcement ; knitting machine ; stroke ; drive ; simulation ; cylinder ; dynamic modeling ; load spectrum reconstruction ; fatigue test ; hydraulic excavator ; n/a ; thema EDItEUR::C Language and Linguistics
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The Special Issue “Demand Response in Smart Grids” includes 11 papers on a variety of topics. The success of this Special Issue demonstrates the relevance of demand response programs and events in the operation of power and energy systems at both the distribution level and at the wide power system level. This reprint addresses the design, implementation, and operation of demand response programs, with focus on methods and techniques to achieve an optimized operation as well as on the electricity consumer.
    Keywords: demand response ; population evolution ; irrational behavior ; Markov state ; non-cooperative game ; solid electric thermal storage ; cyber–physical model ; K-means ; support vector machine ; neural network ; data analysis ; demand response (DR), load profile clustering ; k-means ; targeting of customer ; aggregator ; ramp period ; real-time simulation ; multi-objective optimization ; social welfare metrics ; energy allocation ; load disaggregation ; percentage total harmonic distortion and non-intrusive identification of load pattern ; charging strategy ; optimization ; electricity pricing ; electric vehicle ; flexibility ; flexibility market ; home energy management system ; energy flexibility ; industrial energy management ; demand side management ; control approaches ; energy management ; optimization method ; objective function ; control constraints ; Demand Response ; dynamic thermal rating ; hosting capacity ; transformer ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: The diversity of wood and non-wood forest products is enormous and reflected in their anatomical, physical and chemical properties as well as their potential applications. Special attention should be given to lesser-known species and even to invasive species, which may be profitable when properly managed, thereby decreasing the overexploitation of threatened species. Besides the market importance of stem wood, other tree components and non-wood forest products, often regarded simply as forest residual materials, are valuable forest resources with various potential applications that can strengthen the circular economy. Assessing the characteristics of these diverse materials, such as their structure and anatomy as well as their physical and chemical properties, is fundamental for evaluating their potential and increasing high-quality end-uses. This knowledge will also contribute to sustainable forest management with enhanced forest diversity and species conservation in addition to the reinforcement of certification and environmental policies.
    Keywords: Calamus zollingeri ; Calamus ornatus ; dynamic vapor sorption ; basic density ; volumetric swelling ; white rot ; mold ; Quercus suber L. ; seasonal variation ; cuticular waxes ; leaves ; new species ; morphology ; wood ; properties ; chemical composition ; spectroscopy ; chemometrics ; unconventional species ; Quercus suber ; cork borer ; cork ; phenolics ; tropical species ; wood anatomy ; wood density ; wood color ; multivariate analysis ; species diversity ; dark-brown zone ; lenticular filling tissue ; quantitative anatomical characteristics ; Quercus variabilis ; reproduction cork ; scanning electron microscopy ; sclereid ; virgin cork ; Cytisus scoparius ; liquefied ; optimization ; eco-valorization ; agro-industrial residues ; Asparagaceae ; lignocellulose ; crystalline cellulose ; syringyl/guaiacyl ; anatomy ; Tilia amurensis Rupr. ; Tilia mandshurica Rupr. & Maxim. ; branch ; wood properties ; papermaking material ; tropical timber ; color parameters ; mid-infrared spectroscopy ; FTIR ratios ; environmental factors ; West African Sahel ; Cupressus funebris Endl. wood ; wood knots ; physical properties ; wood color properties ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNA Agribusiness and primary industries::KNAL Forestry industry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
    Keywords: household air pollution ; fine particulate matter ; international environmental health ; cookstove ; respiratory disease ; brick worker ; particulate matter ; heavy metals ; Sulfate-Nitrate-Ammonium ; pollution levels ; mobile sources ; aerosols ; PAHs ; OC and EC ; transport sources ; urbanized coastal station ; grain dust ; health risk assessment ; Monte Carlo simulation ; disability adjusted life year ; multi-media exposure ; health risk ; probabilistic risk assessment ; Lake Chaohu ; PM10 ; health risks ; extreme learning machine ; echo state network ; neural networks ; pollution ; concentration ; indicators ; aberrant values ; nitrogen oxides ; ARIMA ; GRNN ; ARIMA–GRNN ; isolation forest ; LOF ; AOD ; classification ; dendrogram ; PCA ; air quality index ; polluting agents ; respiratory diseases ; monitoring stations ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond.
    Keywords: anxiety ; life satisfaction ; life–work concerns ; melatonin ; cortisol ; biopsychosocial model ; obstetric complications ; patients’ rights ; student ; nursing ; personalized medicine ; HIV ; mobile health ; smartphone application ; symptom management ; nurse practitioners ; nursing home ; COVID-19 ; palliative care ; end-of-life ; dignified death ; older adults ; accidental falls ; fall prevention ; barriers ; patient compliance ; music therapy ; dementia ; caregiver ; RCT ; patient-centred care ; competence ; assessment ; instrument ; measurement ; validity ; reliability ; individual care ; nurses ; older diabetes patients ; physicians ; support ; Parkinson’s disease ; nursing training ; integrated care ; Parkinson nurse ; personalized care ; multidisciplinary care ; patient-centered ; arthritis ; autoimmune disease ; sociopsychological factors ; emotion ; depression ; self-identity ; qualitative study ; observational study ; dysmenorrhea ; kinesio tape ; auricular acupressure ; pain ; nursing care ; patient care planning ; quality of health care ; conditional inference trees ; education ; distance ; learning ; digital ; drawings ; Nigeria ; perinatal loss ; social networks ; stillbirth ; stillborn ; functional status ; health care ; hospitalization ; activities of daily living ; pelvic floor muscle exercises ; pelvic floor dysfunction ; qualitative research ; therapeutic exercise ; therapeutic adherence ; women’s health physiotherapy ; diabetes mellitus type 2 ; prediction model ; LogicRegression ; interpretability ; pelvic organ prolapse ; lifestyle changes ; women’s experience ; n/a ; foot ; foot self-care ; methodological review ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta.
    Keywords: innovative pasta raw materials ; durum ; emmer ; spelt ; pasta ; brewers’ spent grain ; dietary fiber ; einkorn ; functional pasta ; tritordeum ; upcycling ; unconventional ingredients ; nutritional value ; cooking quality ; legumes ; Spirulina Platensis ; resistant starch ; hydrolysis index ; dietary fibre ; annealing ; slowly digestible starch ; carbohydrates ; fiber ; in vitro digestion ; micronization ; brown rice ; air fractionation ; parboiling ; rice pasta ; enriched pasta ; bioactive compound ; tuna ; sea bass ; Ω-3 fatty acids ; sensometrics ; TPA (texture profile analysis) ; glycemic index ; glycemic response ; durum wheat ; landraces ; starch ; available carbohydrates ; glycemic load ; texture profile analysis ; gluten-free ; celiac disease ; fish ; allergy ; pear, date, and apple by-products ; wheat flour ; sensorial properties ; scanning electron microscopy ; multiple factor analysis ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint contains several articles where the molecular mechanisms and structural changes in target proteins on interaction with various viruses and bacteria were studied. In addition, drug-protein interactions, drug–drug interaction mechanisms, anti-Glycating, antioxidant, binding affinity, network pharmacology-driven investigations, and targeted anticancer treatments were also investigated.
    Keywords: RSV ; ectodomain G protein ; heparan sulfate ; protein–ligand interaction ; fluorescence quenching ; molecular docking ; molecular dynamic simulation ; quercetin ; CCL4 ; neurotoxicity ; VirtualToxLab ; oxidative stress markers ; Huperzine A ; molecular dynamics simulation ; fluorescence spectroscopy ; human serum albumin ; neurodegenerative disorders ; drug–protein interactions ; erlotinib ; bovine serum albumin ; binding interaction ; competition ; hepatitis E virus ; methyltransferase ; protein stability ; enzyme assay ; garlic ; antioxidant ; anti-glycation ; glycation ; AGEs ; HSA ; quetiapine ; hydrophobic interaction ; thermodynamic parameters ; seproxetine ; antidepressant ; charge transfer ; π-acceptors ; DFT ; haloperidol ; antipsychotics ; keratoconus ; MMP-2 ; MMP-9 ; molecular dynamics ; MM-GBSA calculations ; pharmacophore mapping ; α-amylase ; advanced glycation end-products ; caffeic acid ; coumaric acid ; coronary artery disease ; phytotherapy ; network pharmacology ; angiogenesis ; zebrafish ; dynamics molecular docking ; NEK7 ; virtual screening ; DFTs ; deep learning ; drug design ; drug repurposing ; structural-based ; cancer ; A. aspera ; β-amyrin ; C. gigantea ; C. procera ; GC-MS ; Minimum inhibitory concentration (MIC) ; Molecular docking ; MD simulations ; Tuberculosis (TB) ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Analytical chemistry is bound to face growing challenges in the future, especially for the quantification of trace analytes in complex matrices. Although the development of increasingly sensitive and specific instrumental techniques has achieved remarkable results, sample preparation is still a fundamental step, often limiting the whole workflow. In the context spawned by the recent international environmental policies that are responsive to the rapport of human activities with the surrounding environment, chemistry cannot hesitate to give its contribution. Almost pioneeringly, in analytical chemistry, we have been talking for some time about “green analytical chemistry”, its guiding principles, and the development of eco-friendly analytical approaches. However, the new and still open challenge is advance not only in eco-compatibility but mainly in eco-sustainability, rooting the future of analytical chemistry in new perspective aimed at minimizing the environmental impact of the analytical process by placing environmental cost as a priority aim on par with analytical performance. This is the reprint of a Special Issue that includes contributions focused on the progress in analytical chemistry based on the arguments previously raised and discussed, with a particular reference to eco-compatibility and eco-sustainability. The contributions include the development of low environmental impact methods and/or techniques or their applications.
    Keywords: dyes ; fatty acids ; microextraction ; magnetic ionic liquid ; sample preparation ; dispersive liquid–liquid microextraction ; single drop microextraction ; GC ; HPLC ; ionic liquids ; denitrogenation ; extraction ; pyridine ; quinoline ; aniline ; simulated oil ; adsorption ; gum Arabic ; magnetite ; nano-composite ; lead(II) ; mercury removal ; magnetic ; manganese ; cobalt ; iron ; spinel ; crosslinker ; phenolic acids ; vinylimidazole ; anion exchanger ; co-polymer ; solid-phase extraction ; sustainable analytical sample preparation ; indoor air quality ; fragrances ; indoor pollution ; endocrine disruptors ; analytical method ; GC-MS ; musks fragrances ; emerging contaminants ; α-isomethylionone ; halloysite nanotubes ; organosilyl-sulfonated halloysite nanotubes ; solid phase extraction ; pyrrolizidine alkaloids ; honey ; chlorzoxazone ; greener HPTLC ; paracetamol ; simultaneous detection ; validation ; AGREE ; traditional HPTLC ; vitamin D3 ; pulsed electric field ; bioactive compounds ; optimization ; mushrooms ; Agaricus bisporus ; phenyboronic-acid-functionalized ; Fe3O4 magnetic nanoparticles ; ortho-dihydroxy-containing compounds ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PN Chemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Civil engineering structures may vibrate due to different sources of excitations such as earthquakes, wind, traffic, humans, etc. The resulting vibrations may not be acceptable from the perspective of vibration comfort or can even impair the structure's safety. Depending on the excitation mechanism, anti-vibration measures range from increasing the structural damping using local dampers, decoupling the structure from the disturbance using vibration isolators and compensating for the excitation forces using vibration compensators. The Special Issue "Efficient Damping and Isolation Systems for Civil Structures" presents some of the recent advances in the associated fields of research and development.
    Keywords: isolation ; high damping rubber bearing ; low shape factor ; performance test ; experiment ; three-dimensional (3D) seismic isolation ; vertical seismic isolation device ; disc spring ; helical coil spring ; steel damper ; laminated rubber bearing ; seismic energy dissipation ; nuclear power plant equipment ; seismic isolation frequency ; hysteretic behavior ; cable ; control ; damping ; semi-active ; negative stiffness ; vibration ; liquid storage tank ; MetaFoundation ; time domain analysis ; earthquake ; passive control ; stop band ; suspended ceiling systems ; passively controlled structure ; pulley tackle mechanism ; shake table test ; simulation analysis ; tower-like structures ; tuned liquid gas damper ; elastic membrane ; gas spring ; gas volume ; SA-TLGD ; TLCGD ; TLCD ; TMD ; inerter ; optimization ; TMDI ; vibration mitigation ; tuned sloshing damper ; TSD ; tuned mass damper ; numerical simulation ; coupled simulation ; computational wind engineering ; CWE ; hysteresis ; internal resonances ; nonlinear modal interaction ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This book presents a collection of papers revealing the impact of advanced computation and instrumentation on healthcare. It highlights the increasing global trend driving innovation for a new era of multifunctional technologies for personalized digital healthcare. Moreover, it highlights that contemporary research on healthcare is performed on a multidisciplinary basis comprising computational engineering, biomedicine, biomedical engineering, electronic engineering, and automation engineering, among other areas.
    Keywords: eHealth ; mHealth ; telemedicine ; telehealth ; social sciences ; bibliometrics ; telediagnostic ; project management ; funding ; IT infrastructure ; cross-border multiprofessional team ; European Union ; Interreg ; reporting ; quality control ; resident ; diagnostic error ; artificial intelligence ; healthcare AI ; deployment and scaling ; medical center ; critical factors ; stakeholders ; health information technology ; information sharing ; hospital costs ; poverty ratio ; concentration ; continuous glucose monitoring ; insulin pump ; continuous subcutaneous insulin infusion ; pediatric diabetes ; biomedical data ; medical imaging ; shared data ; massive databases ; AI-based healthcare solutions ; trueness ; 3D printing ; milling ; interim dental crown ; digital dentistry ; dental device ; data mining ; bio-signal analysis ; bio-signal repository ; execution engine ; bio-signal monitoring ; digital healthcare ; patient-centric ; blockchain ; federated learning ; coronavirus (COVID-19) ; pandemic management ; healthcare transformation ; public health strategies ; stroke detection ; portable head scanner ; low-intensity EM waves ; intrinsically safe ; low carbon footprint ; orthodontic treatment ; clear aligners ; smart application ; AI ; computerized learning ; behavior change techniques ; decision tree algorithm ; digital interventions ; mental health literacy ; audiovisual ; dentistry ; computer-controlled local anesthetic delivery ; ultrasounds ; chemomechanical caries removal ; modern technologies ; laser ; ozone ; healthcare ; emergency department ; patient flow ; simulation modeling ; agent-based modeling ; pandemic decision support ; additive manufacturing ; patient-centric dosage form ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: The papers published in this Special Issue report on recent studies investigating the exploitation of by-products produced by the food industry. The topics investigated include the extraction setups used for valuable food waste by-products and their applications as adjuncts to food preparation; the appropriate selection of solvents and extraction processes; and the interactions between extracted fractions and supplementary foods. The papers evaluate a wide variety of foodstuffs and provide results regarding the extension their shelf-lives and activities as functional foods.
    Keywords: by-product ; rheological properties ; optimization ; melting profile ; antioxidant activity ; mayonnaise ; olive mill wastewater ; oxidative stability ; phenolic extract ; pork ; fatty acid ; amino acid ; mineral ; meat ; sustainability ; spent biomass ; prebiotic potential ; enzymatic digestion ; biorefinery ; circular economy ; by-products ; ovine scotta ; bioactive peptides ; bromelain ; pancreatin ; dipeptidyl peptidase IV inhibition ; ovine second whey cheese ; enzymatic hydrolysis ; wasted bread ; bioprocessing ; lactic acid bacteria ; soil amendment ; byproducts ; vegetable oil industry ; phenolics ; flavonoids ; photochemiluminescence ; cold-pressed oil by-product ; gum ; thixotropic behavior ; low-fat vegan mayonnaise ; thickeners ; gelling agents ; tomato pomace ; lycopene ; β-carotene ; extraction ; food by-products ; deep eutectic solvents ; non-thermal drying ; stilbene ; vine shoots ; viticulture waste ; trans-resveratrol ; ε-viniferin ; Italian varieties ; no-waste ; omega-3 ; smart sensors ; reuse ; fish oil industry ; recovery ; chemometrics ; lipid profile ; aquafaba ; cold-pressed oils ; confocal laser scanning microscopy ; egg replacement ; physicochemical properties ; radical scavenging activity ; vegan mayonnaise ; Amberlite resin ; hazelnut skin ; polyphenols ; Pinot noir pomace ; solid–liquid extraction ; valorization ; fatty acids ; derivatization ; cranberry pomace ; dietary fiber ; technological properties ; kiwi byproducts ; probiotic ; prebiotic ; Lactobacillus casei ; ingredients ; functional foods ; microbial spoilage ; lipidic oxidation ; antioxidant ; predictive microbiology ; food preservation ; food safety ; sustainable strategy ; by-product reuse ; kinetic parameters ; Olea europaea ; waste reuse ; inulin ; high polymerization degree ; functional pasta ; glycemic index ; prebiotics growth ; n/a ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::T Technology, engineering, agriculture
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The sustainable development of our planet depends on the use of energy. The increasing world population inevitably causes an increase in the demand for energy, which, on the one hand, threatens us with the potential to encounter a shortage of energy supply, and, on the other hand, causes the deterioration of the environment. Therefore, our task is to reduce this demand through different innovative solutions (i.e., both technological and social). Social marketing and economic policies can also play their role by affecting the behavior of households and companies and by causing behavioral change oriented to energy stewardship, with an overall switch to renewable energy resources. This reprint provides a platform for the exchange of a wide range of ideas, which, ultimately, would facilitate driving societies toward long-term energy efficiency.
    Keywords: natural resources ; globalization ; energy ; nonparametric causality in quantiles ; energy security ; power market ; near-zero emission technologies ; oxy-fuel combustion cycles ; emission rights sales mechanism ; economic assessment ; Oil Companies ; innovations ; investments in R&amp ; D ; forecasting the Innovation activities ; industry 4.0 ; Agenda 2030 ; sustainable human development ; measuring development ; energy sustainability ; indirect measurement ; composed indexes ; forecasting ; linear regression ; planning ; polynomial regression ; power supply ; green building ; housing projects management ; sustainable construction ; renewable energy sources ; real estate developers ; deviation ; energy dependence ; energy efficiency management ; energy saving ; cost ; risk limit ; energy industry ; energy supply ; energy intensity ; energy efficiency ; energy industry risks ; dilemma ; development ; Kazakhstan ; energy transitions ; Latin America ; power system ; sustainability ; economic growth ; pollution ; renewable energy ; oil and gas industry ; investments ; rating ; competitiveness ; financial analysis ; risk ; profitability ; merchandising technologies ; correlation ; scenario ; social development ; optimization ; investment ; financial portfolio ; financial leverage ; integral rating ; industry rating ; high-tech company ; decision-making ; minimax ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-11
    Description: This reprint aims to address the challenges modern-day buildings face in the context of high energy and resource consumption and climate change. One of the ways to address the issues is holistic design and operation of high-performance buildings in the area of energy efficiency, occupant health, and comfort. All this should be achieved through synergic interconnectedness between parameters such as the indoor–outdoor environment, sustainability, and resilience. Through different chapters, this reprint highlights the key areas, namely, the optimization of building design parameters, the impact of the use of modern-day phase-change materials, the adaptation of occupants and buildings to climate change, the mitigation of urban overheating by cool roofs, and reducing energy demand and CO2 emissions.
    Keywords: climate change ; bioclimatic design ; passive design ; energy efficiency ; overheating ; building resilience ; robustness ; shape factor ; building ; thermal envelope ; energy demand ; CO2 emissions ; white roofs ; cool roofs ; reflective material ; cost-benefit ; energy savings ; urban heat island ; thermal comfort ; indoor environmental quality ; educational buildings ; energy consumptions ; local discomfort ; building energy retrofitting ; phase change materials ; aerogel render ; heat stress risk ; emission ; lifecycle cost ; peak cooling load ; residential building ; building envelope ; multi-objective genetic algorithm ; TRNSYS ; climate zone ; multi-criteria decision making ; CRITIC ; TOPSIS ; capture devices ; variables ; field surveys ; thermal perceptions ; adaptive actions ; hostel dormitories ; composite climate of India ; reflective materials ; mitigation ; outdoor comfort ; visual comfort ; heat stress ; optimization ; skyscrapers ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: As we know, strokes are one of the world's leading causes of death, and the cruel aspect of a stroke is that it leaves people with severe functional disability and/or cognitive impairment. Strokes have a significant impact on economies worldwide, as it is estimated that about 10% of the male population and 8% of the female population are affected by them. Such people need personal help in their everyday life and must be materially supported by social services. With the advancement of medicine, artificial intelligence, and new technologies have been developing rapidly and are gradually applied in diseases of the nervous system, increasingly helping diagnosis, treatment, rehabilitation, and prognosis of disease.This Special Issue has collected the 14 papers on artificial intelligence and new technologies in strokes, including in the aspects of diagnosis, treatment, prognosis, rehabilitation, and nursing. We welcome your reading.
    Keywords: non-invasive brain stimulation ; stroke ; spasticity ; meta-analysis ; hemiplegia ; electromyographic bridge ; upper limb rehabilitation ; randomized controlled trial ; hypoxic ischemic encephalopathy ; disorders of consciousness ; metabolic connectivity ; positron emission tomography ; 18F-fluorodeoxyglucose ; hand function rehabilitation ; hand rehabilitation robot ; computer vision technology ; wearable devices ; sensors ; artificial intelligence ; brain–computer interface ; active rehabilitation training ; motor function ; brain function ; executive function ; postural control ; gait ; repetitive transcranial stimulation ; facial paralysis ; peripheral magnetic stimulation ; blood flows ; laser speckle ; stroke rehabilitation ; upper limb ; automated system ; motor function assessment ; Fugl-Meyer Assessment ; motor attempt (MA) ; EEG ; deep learning method ; overlapping time window ; facial expression recognition (FER) ; vision transformer (ViT) ; convolutional neural networks (CNNs) ; rehabilitation ; assessment ; upper extremity ; hand ; brain–computer interfaces ; motor task ; sensorimotor rhythm ; hand rehabilitation ; motor imagery ; virtual reality ; rTMS ; DTI ; immersive virtual reality ; post-stroke cognitive impairment ; aging ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Hyperbaric oxygen is a known therapeutic agent, and treatments using this agent remain a matter of discussion and research. This Special Issue collection will add new knowledge and also offer some not so usual approaches to foster contemporary understanding and potential benefit for patients and scholars.
    Keywords: hyperbaric oxygen therapy (HBOT) ; Hyperoxia ; wound healing ; antimicrobial properties ; Coronavirus Disease-19 (COVID-19) ; critical flicker fusion frequency ; threshold of flicker fusion ; neuropsychology ; diving and hyperbaric medicine ; minimal hepatic encephalopathy ; diabetes ; hyperbaric oxygen therapy ; glycaemia ; oxygen ; hyperbaric oxygen ; epigenetics ; normobaric oxygen paradox ; hyperoxic-hypoxic paradox ; frostbite ; classification ; cold disease ; prognosis ; amputation ; medical outcome ; atmosphere exposure chambers ; diving physiology ; decompression ; periodontal disease ; oral health index ; dental mobility ; periodontal pockets depth ; subfoveal choroidal thickness ; intraocular pressure ; central corneal thickness ; central serous chorioretinopathy ; flow-mediated dilation ; arterial stiffness ; endothelial dysfunction ; n/a ; FMD ; underwater ; hyperbaric ; commercial diver ; off-shore energy operation ; human ; adverse effects ; autonomic nervous system ; lung ultrasound ; mixed gas diving ; pulmonary function ; technical diving ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: We are honored to announce this reprint, containing contributions from the top experts in the field of logic and fuzzy logic. In total, this reprint consists of 10 papers that were selected from more than 20 submissions. The 10 papers comprising the reprint are the product of re-known experts in fuzzy logic from all over the world, such as Canada, Poland, China, Slovakia, Lithuania, Turkey, Pakistan, Germany, Serbia, Portugal, Taiwan, Norway, India, Saudi Arabia, Thailand, and Mexico. We expect that the papers comprising the Special Issue will contribute to an advancement in the state of the art in the fields of logic and also fuzzy logic.
    Keywords: fuzzy-sets ; fuzzy-random variables ; distribution generating function ; fuzzy binomial distribution ; Fuchs distribution ; MADM ; Aczel–Alsina operations ; IVIFNs ; IVIF Aczel–Alsina geometric aggregation operators ; interval type-3 fuzzy theory ; fuzzy control ; manufacturing ; Vietè’s method ; Newton–Raphson method ; regula falsi method ; testing of algorithms ; foundations of mathematics ; arithmetic ; set theory ; spatial fuzzy C-means ; COVID-19 ; rustbelt states ; extrapolation ; interpolation ; proving ; refuting ; improving ; fuzzy set ; linear Diophantine fuzzy sets ; linear Diophantine fuzzy relations ; level cut relations ; rough approximations on two universes ; decision analysis ; multi-valued logic trees ; hydraulic proportional valve ; weighting factors ; optimization ; granular computing ; formal concept analysis ; intuitionistic fuzzy sets ; periodicity ; spatial and temporal aspects ; knowledge discovery ; n/a ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This book presents recent advances in the field of bone tissue engineering, including molecular insights, innovative biomaterials with regenerative properties (e.g., osteoinduction and osteoconduction), and physical stimuli to enhance bone regeneration.
    Keywords: bone ; collagen type I ; alginate ; conditioned medium ; viability ; MSC ; osteogenesis ; pulsed electromagnetic field ; osteogenic factors ; wool keratin scaffolds ; bone tissue engineering ; biocompatibility ; biomaterials ; bone augmentation ; bone conduction ; bone grafting ; calcium hydroxyapatite ; tissue regeneration ; dental implants ; osseointegration ; osteoporosis ; zoledronate ; animal model ; titanium membrane ; titanium foil ; occlusive titanium barrier ; guided bone regeneration ; osteoporotic condition ; xenograft ; bone regeneration ; titanium implants ; additive manufacturing ; reused powder ; unit cell topology ; tissue engineering ; mechanical properties ; stem cells ; surface functionalization ; titanium ; protein adsorption ; surface modifications ; cell interactions ; collagen hydrogel ; cell delivery ; olfactory ectomesenchyme stem cells ; bioactive glasses ; alkali-free ; sol–gel ; bone remodeling ; bone disorders ; biomechanics ; scaffolds ; microenvironment ; 3D bioprinting ; computational modeling ; bone implant ; bone defects ; chitosan ; degree of deacetylation ; bone formation ; X-ray micro CT ; histology ; sheep tibia ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This reprint focuses on the current progress in sports medicine, with a specific interest in surgery, exercise therapy, and multi-disciplinary research. With the advancement of society, more attention is paid to the quality of life, which emphasizes the importance of sports and exercise. Correspondingly, there is a great need for sports medicine. This issue collected novel findings on sports medicine in surgery, conservative therapy, and the application of exercise training in other disorders
    Keywords: shoulder ; rotator cuff ; allografts ; demineralized bone matrix ; biologics ; diabetes mellitus ; aerobic training ; resistance training ; vascular function ; meta-analysis ; femoroacetabular impingement ; hip arthroscopy ; longitudinal capsulotomy ; femoroplasty ; labrum repair ; degenerative lumbar diseases ; albumin-to-alkaline phosphatase ratio ; spinal fusion rate ; prognostic marker ; arterial hypertension ; exercise hypertension ; blood pressure ; exercise testing ; sports injuries ; machine learning ; injury prediction ; sports monitorization ; elite football ; performance ; systemic inflammation ; physical endurance ; physical fitness ; maximal aerobic capacity ; gingivitis ; cardiac rehabilitation ; exercise therapy ; balance exercises ; cardiovascular diseases ; ACLR ; hamstring tendon with preserved tibial insertion ; MRI ; T2 ; cartilage volume ; gait retraining ; running-related injuries ; kinetics ; kinematics ; rehabilitation ; rotator cuff tear ; rotator cuff repair ; bone quality ; osteopenia ; osteoporosis ; anchor pullout ; pullout strength ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Novel Anticancer Strategies (Volume II) reviews important findings and updates within the cancer therapy field of great interest to those in academic research studying the development and validation of novel anticancer approaches. The Editor invited preeminent specialists to contribute to original and review articles devoted to key areas of major progress and expectations. Key Features:Nanoparticle-based drug delivery in cancer therapy;Nanoerythrosomes;Cancer immunotherapy;Therapeutic vaccines;Oncogenic and tumor suppressive components of the cell cycle;Antimitotics in cancer clinical trials;Multifunctional enzymes as anti-cancer drug targets;Targeting undruggable proteins and non-coding RNAs;Cell-penetrating peptides;Repurposed cancer drugs in clinical trials;Circulating tumour cells.
    Keywords: Breast cancer treatment ; Photodynamic therapy ; Inorganic nanoparticles ; Active targeting ; cathepsins ; BAX ; MOMP ; ubiquitination ; apoptosis ; chemotherapy ; cancer ; nanoerythrosome ; nanoerythrocyte ; nanovesicles ; biomimetic ; cancer therapy ; diagnostics ; imaging agents ; cell cycle ; cyclin-dependent kinase ; p16 ; p21 ; p27 ; breast cancer ; prognosis ; drug delivery ; HL60 ; leukemia ; prodrug ; resistance ; retinoic acid ; vitamin K ; drug repurposing ; COVID-19 ; pandemic ; vaccination ; multi-drug resistance ; enhanced permeation and retention effect ; nanotherapeutics ; cancer theranostic ; clinical translation ; cell-penetrating peptides ; protein transduction domains ; tumor imaging ; targeted therapies ; dog ; comparative oncology ; molecular targets ; spheroids ; tumoroids ; hydrogel ; collagen ; agarose ; mammary spheroids ; tissue engineering ; cisplatin ; melanoma ; melanin nanoparticles ; cytotoxicity ; laser medical applications ; hyperthermia ; antimitotics ; mitotic slippage ; spindle assembly checkpoint ; clinical trials ; TRAIL ; cancer stem cells ; TRAIL resistance ; angiogenesis ; on-demand drug delivery systems ; electrospun nanofibers ; poly (N-isopropylacrylamide) ; gold nanorods ; paclitaxel ; β-Cyclodextrin ; SPIONs ; metallodrugs ; RAPTA derivatives ; phosphino-amine ligands ; CTCs ; NSCLCs ; metastasis suppression ; curcumin ; flavonoids ; TNBC ; immunotherapy ; immune checkpoint ; nanocarrier ; combinational immunotherapy ; lung cancer ; miRNA ; oncomiRs ; photodynamic therapy PDT ; porphyrin ; iron oxide nanoparticles ; mesoporous silica nanoparticles ; antibody functionalization ; targeted drug delivery systems ; molecular-targeted therapies ; multifunctional enzymes ; HCC ; CHRNA5 ; metastasis ; stemness property ; sorafenib sensitivity ; neoantigens ; vaccine ; Patched ; chemotherapy resistance ; metastases ; persistent cells ; adrenocortical carcinoma ; BUB3 ; mitosis ; senescence ; anticancer target ; boron neutron capture therapy ; 4-borono-l-phenylalanine ; drug discovery ; solubility ; mebendazole ; polymer ; HPMA ; controlled drug release ; PLK1 ; BI2536 ; Navitoclax ; slippage ; PD-1 ; gemcitabine ; new anti-cancer drugs ; precision medicine ; undruggable targets ; non-coding RNAs ; oligonucleotide therapeutics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Almost all fields of dentistry are closely related to newly developed materials, and all clinical improvements often follow, or, in any case, go hand in hand with the creation and the development of innovative and higher performing materials, instruments, and equipment. Thanks to contemporary applications of dental materials, the effectiveness of clinical dentistry has made remarkable advances. In recent years, thanks to digital technology and the frenetic development of the dental industry, new materials have been developed and proposed in many fields of dentistry: prosthesis, restorative dentistry, endodontics, implantology, and orthodontics. Unfortunately, as often happens, this productive challenge is not always accompanied by valid scientific research, and consequently the clinician finds new materials at their disposal that are not necessarily better than the old. Further studies are needed to gain relevant evidence for all recently introduced dental materials. This reprint includes research articles, clinical studies, review articles, and case reports focused on the latest advances and prospects of dental materials concerning all fields of dentistry.
    Keywords: MIH ; hypersensitivity ; enamel infiltration ; hypomineralization ; marginal adaptation ; fixed partial denture ; dental technology ; cobalt–chromium alloys ; scanning electron microscopy ; titanium ; dental implants ; hydrophilic ; hydrocarbon ; biological ageing ; UV photofunctionalization ; alveolar bone defects ; guided bone regeneration ; titanium meshes ; customized titanium meshes ; laser melting process ; electron beam melting ; composite restoration ; microleakage ; oblique layering technique ; horizontal layering technique ; composite ; fluorescence ; de-bonding ; residuals ; enamel damage ; orthodontics ; radiolucent sign ; OPG ; CBCT ; third molar ; oral surgery ; periapical sign ; biofilm ; bone healing capacity ; infected gutta-percha ; rat calvarium ; zirconia ; airborne particle abrasion ; femtosecond laser ; flexural strength ; surface roughness ; bond strength ; brackets ; dry ; wet and moistened enamel ; adhesion ; calcium phosphate ; radiation-induced center ; hyperfine interaction ; EDNMR ; ESEEM ; ENDOR ; biomaterial ; bone regeneration ; bone substitute ; dental implant ; octacalcium phosphate ; TiN ion plating ; metal allergy ; orthodontic wire ; micro-implants ; success rate ; insertion ; loading ; biocompatibility ; compliance ; dental material ; restorative material ; glass ionomer ; resin-modified glass ionomer ; pH ; acidity ; oral environment ; dental filling ; dental restoration ; apical negative pressure irrigation ; calcium hydroxide removal ; intracanal medicament ; mechanical activation ; ultrasonic activation ; osseoincorporation ; osseointegration ; trabecular metal ; guided tissue regeneration ; barrier membranes ; allergology ; demineralized dentin matrix ; human demineralized dentin matrix ; human ; bone graft ; FT-MIR ; SEM ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies.
    Keywords: infections ; cancer ; children ; bacteremia ; pneumonia ; sarcoma ; solid tumor ; outcome ; KI67 ; EZRIN ; 18F-FDG PET/CT ; random forest ; radiogenomics ; chemotherapy response ; metastasis ; serine-threonine kinase receptor-associated protein ; neuroblastoma ; CRISPR-Cas9 ; metronomic chemotherapy ; maintenance therapy ; high-risk ; Ewing sarcoma ; RNA-binding proteins ; regulation network ; prognosis prediction ; risk model ; melanotic neuroectodermal tumor of infancy ; inoperable ; metastatic ; recurrent ; chemotherapy ; adjuvant ; neoadjuvant ; systemic treatment ; childhood malignant bone tumors ; survivorship ; late effects ; somatic disease ; cohort study ; rhabdomyosarcoma ; targeted therapies ; cell surface proteomics ; B7-H3 ; stress ; allostasis ; stress regulatory pathways ; stress dysregulation ; stress reactivity ; early life stress ; childhood cancer ; cytotoxic cancer treatment ; interventions ; ependymoma ; risk stratification ; molecular group ; prognosis ; nephroblastoma ; clinical malformations ; cancer predisposition syndromes ; tumor surveillance ; n/a ; DSRCT ; EWSR1-WT1 ; preclinical model ; in vitro model ; pediatric cancer ; pediatric ; brain ; tumor ; medulloblastoma ; glioma ; natural products ; drug discovery ; fungal secondary metabolites ; soil microbes ; RH30 ; RD ; EZH2 ; epigenetic ; EPZ005687 ; DZNep ; AdOx ; malignant rhabdoid tumor ; hepatoblastoma ; small cell undifferentiated (SCUD) hepatoblastoma ; SMARCB1 ; INI1 ; pediatric liver tumors ; drug repurposing ; PI3K pathway ; epigenetics ; Fimepinostat ; LPAR1 ; LPA ; tumor metastasis ; bioinformatics analysis ; ulixertinib ; ERK inhibition ; combination therapy ; c-Myc/N-Myc ; cell differentiation ; ATRA ; SOX4 ; diffuse intrinsic pontine glioma ; immunotherapy ; immune microenvironment ; immune checkpoint inhibitor ; vaccine ; oncolytic virus ; myeloid sarcoma ; chloroma ; acute myeloid leukemia ; pediatric cancers ; VIPN ; DIC ; MDR ; drug transporters ; childhood acute leukemia ; early complication ; hyperleukocytosis ; risk factor ; survival outcome ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The researchers involved in this reprint will continue their studies to improve the existent dental biomaterials in order to achieve optimal dental treatment with biocompatible, bioactive, and stable properties. As the Guest Editors, we sincerely value and thank the reviewers for their insightful comments and the support of the team at Bioengineering. Finally, we express our gratitude to all contributing authors for their valuable research. Altogether, the 16 research papers/reviews in this Special Issue entitled "Recent Advances in Biomaterials and Dental Disease" reflect the importance of in vitro and in vivo studies for improving the efficacy of using biomaterials in dental treatment.
    Keywords: adhesion ; bonding ; dental porcelain ; glass ceramics ; orthodontic bracket ; shear strength ; aligner ; cytotoxicity ; estrogenicity ; invisalign ; monomer ; retainer ; 3D resin ; endodontic sealer ; polyphenols ; resveratrol ; pyrogallol ; biological activity ; piezoelectric surgery ; endodonticsurgery ; crack formation ; ultrasonic tip ; retropreparation ; antibacterial effect ; dental impressions ; disinfectant agents ; disinfection ; oral bacteria ; implant periapical lesion ; implant failure ; peri-implantitis ; endodontic surgery ; complication ; retreatment procedure ; filling materials removal ; revision system ; sonic activation ; oval-shaped canal ; decontamination ; lithium disilicate ; resin ; saliva ; shear bond strength ; crowns ; fixed prosthodontics ; resin composite ; survival ; bond strength ; contact angle ; dentin ; desensitizers ; resin cements ; 3D printing ; digital light processing ; interim crown ; in vivo study ; wear ; endodontists ; general practicing dentists ; root canal treatment ; quality ; undergraduate students ; traumatic dental injury ; tooth fracture ; adhesive reattachment ; pulp ; regeneration ; revitalization ; transplant ; root ; maxillary premolars ; upper premolars ; canal ; root canal anomalies ; anatomical variations ; root morphology ; coneless ; MEA technique ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: This reprint focuses on recent advances in the clinical care of patients with acute and chronic coronary syndromes. We must accumulate novel scientific and clinical knowledge in this field to develop seamless treatments and preventive strategies for this patient population. Furthermore, accumulated data have implicated that there are some residual risk factors for coronary syndromes, and the clinical management of cardiovascular/non-cardiovascular complications associated with coronary syndromes is also a critical concern. We hope that this reprint will facilitate the management of future patients with coronary syndromes; however, further research is still required. It is also our hope that this reprint will promote future research to enable a better understanding of the clinical practice of coronary syndromes.
    Keywords: statin ; myocardial infarction ; renal function ; coronary CT angiography ; subtraction ; fractional flow reserve ; coronary artery disease ; Agatston score ; uric acid ; endothelial function ; ischemic heart disease ; ischemia with no obstructive coronary artery disease ; angioplasty ; drug-eluting stents ; non-ST-elevation myocardial infarction ; multivessel disease ; acute coronary syndrome ; chronic coronary syndrome ; xanthine oxidoreductase ; coronary artery spasm ; gender differences ; vasospastic angina ; microvascular spasm ; microvascular vasodilatory function ; high coronary thrombus burden ; tissue plasminogen activator ; catheter-directed thrombolysis ; olmesartan ; amlodipine ; rosuvastatin ; single pill combination ; phase III clinical trial ; computed tomography ; computed tomography perfusion ; myocardial perfusion abnormality ; aspirin ; clopidogrel ; prasugrel ; P2Y12 inhibitor ; bleeding ; nitrate ; vasodilator ; biomarker ; mortality ; risk-score model ; n/a ; NGAL ; contrast-induced acute kidney injury ; percutaneous coronary intervention ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: This book contains research articles on the advances in the aetiology of idiopathic scoliosis (IS), the spinal growth related to the implementation of growth modulation for the surgical treatment of early-onset IS, the non-surgical treatment of IS using Physiotheraputic Scoliosis Specific Exercises, and braces. Additionally, it focuses on issues related to surgical treatment, issues related to body posture and the quality of life of this sensitive group of people. The high quality of published papers in this Special Issue of the JCM serve these objectives.
    Keywords: idiopathic scoliosis ; health-related quality of life ; cultural adaptation ; Italian Spine Youth Quality of Life Questionnaire ; systematic review ; meta-analysis ; adolescent idiopathic scoliosis ; brace therapy ; brace concepts ; rigid brace ; night time brace ; ring apophysis ; maturation ; ossification ; fusion ; scoliosis ; nighttime orthotic treatment ; surgery ; quality of life ; paraspinal muscles ; cross-sectional area ; posterior approach ; computed tomography ; Italian spine youth quality of life questionnaire ; SRS-22 ; 22q11.2 deletion syndrome ; human model ; neuromuscular scoliosis ; radiography ; MRI ; curve morphology ; intraspinal anomaly ; body height ; pulmonary function test ; Cobb angle ; iTRAQ ; α-actin ; progressive ; differentially expressed proteins ; bracing ; physiotherapeutic scoliosis-specific exercise ; physical activity ; adherence ; spinal appearance ; shared decision-making ; personalised approach ; sclerostin ; osteocytes ; β-catenin ; Wnt signaling pathway ; scoliometer ; truncal asymmetry ; lateral spinal profile ; surface topography ; aetiology ; spinal deformities ; pathobiomechanics ; follow-up study ; Rett syndrome ; motor skills ; telerehabilitation ; physical therapy modalities ; home exercise program ; neurodynamic functions ; assessment ; pain ; treatment ; early onset scoliosis ; non-operative treatment ; body posture ; sports activity ; corrective exercises ; digital photography ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: Advancements in medical imaging modalities have resulted in increasing the importance and demand of pediatric radiology. This reprint showcases various examples of advanced research in pediatric radiology and nuclear medicine. These include the use of medical imaging modalities such as computed tomography, general radiography, magnetic resonance imaging, positron emission tomography, single-photon emission computed tomography, and ultrasound for diagnosis, as well as the performance of artificial intelligence (AI) in computer-aided detection and diagnosis in the pediatric population. The radiation dose issue of pediatric radiological examinations and emerging AI technology for dose reduction, as well as the use of three-dimensional printing based on medical images for pediatric surgical planning, healthcare professional education, and patient–clinician communication are also covered.
    Keywords: as low as reasonably achievable ; computed tomography ; convolutional neural network ; deep learning ; dose reduction ; generative adversarial network ; image processing ; machine learning ; medical imaging ; noise ; contrast-enhanced ultrasound ; head ultrasound ; brain death ; infants ; ancillary test ; child ; paediatric ; infant ; adolescent ; chest X-ray ; CXR ; chest radiography ; COVID-19 ; SARS-CoV-2 ; coronavirus ; biliary atresia ; ultrasonography ; diagnostic accuracy ; intraoperative cholangiography (IOC) ; diagnostic performance ; elastography ; three-dimensional printing ; congenital heart disease ; children ; model ; personalized medicine ; application ; confusion matrix ; disease identification ; image interpretation ; pneumonia ; artificial intelligence (AI) ; deep learning (DL) ; paediatric pneumonia ; chest radiograph ; computer-aided detection (CAD) ; cumulative ; radiation dose ; acute tonsillitis ; shear wave elastography ; stiffness ; pediatric ; magnetic resonance imaging ; infection ; neck ; emergency medicine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: With the deep integration of cutting-edge technologies such as artificial intelligence, big data, and the Internet, ship propulsion control systems are also gradually undergoing a transformation from the mode of automatic control to intelligent control. In particular, the smart ship concept has become a key factor in the maritime industry’s ambition to achieve sustainable green development. Currently, the development of all-electric propulsion and innovative hybrid ship propulsion systems is a priority, so that the efficiency of ship propulsion systems might be improved. Therefore, the aim of this monograph is to describe the intelligent control of ship propulsion systems. In this regard, this monograph deals with new approaches to the design of ship power systems. Among them, in terms of intelligent control, and using simulation experiments for comparison, the learning ability relied on by artificial intelligence is utilized to handle the collected data and generate corresponding commands, thus ensuring the safety and stability of the ship's movement. The main objective of this Special Issue is to fill existing knowledge gaps and provide additional ideas on the intelligent control of marine propulsion systems. Finally, we would like to express our deepest gratitude to the staff of MDPI Books and the editorial team of Marine Science and Engineering, especially the assistant editors of this Special Issue, the gifted authors, and the diligent and expert reviewers.
    Keywords: automation ; autonomous guidance ; green propulsion technologies ; marine engine ; safety and efficiency ; ship propulsion dynamics ; simulation ; smart control ; optimization ; weather routing ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: This Special Issue aimed to collate recent works regarding the planning and control of energy systems. In particular, this Special Issue focuses on microgrids. This kind of system enables optimal integration of renewable energy sources, electric vehicles, energy storage, and demand-side management strategies, thus proposing a valuable framework through which to implement the decarbonization of the electricity sector. Special attention is given to those works devoted to systems with high penetration of renewables and advanced demand response strategies. Literature reviews are also included in this Special Issue, and some real-life experiences are described and analyzed.
    Keywords: optimization algorithm ; control system ; renewable energy ; PSO ; GWO ; battery storage energy ; electric vehicle ; photovoltaics ; BESS ; optimization ; AOA algorithm ; uncertainty ; distribution network ; DC multi-microgrid system ; carbon emissions ; economic dispatch ; across-time-and-space energy transmission ; cooperative multi-objective optimization ; PV ; wind turbine ; biomass system ; heap-based optimizer ; Franklin’s and Coulomb’s algorithm ; sooty tern optimization ; energy cost ; metaheuristics ; solar cell systems ; elephant herding optimization ; alpha tuned EHO ; cultural-based ; biased initialization ; parameter identification ; single diode ; double diode ; three diodes ; modular multilevel converter (MMC) ; fault-tolerant ; voltage source modular multilevel converter (VSMMC) ; SPWMLSC ; SPWMPSC ; STHILSC ; STHIPSC ; optimal energy management ; multi-agent system ; multi-energy carrier ; renewable energy sources ; microgrids management ; renewable energy resources ; isolated microgrids ; optimization techniques ; demand-side management (DSM) ; distributed generations (DGs) ; energy management systems (EMS) ; renewable energy sources (RES) ; waste to energy (W2E) ; microgrid architecture ; smart infrastructure ; resilience ; optimization model ; critical node identification ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-28
    Description: System dynamics is a simulation modeling approach to strategic and policy analysis that has been applied to many health care and public health issues since the 1960s and has become increasingly prevalent since the 2000s. The ten articles in this reprint appeared in a Special Issue of Systems and cover a broad cross-section of relevant methodological topics as well as applications to specific health problems.One methodological article describes the use of cascaded system archetypes, with an application to reducing hospital congestion. Another discusses Monte Carlo uncertainty analysis, with an application to the US opioid crisis. Three of the articles describe models of community response to severe shocks, including recovery from the COVID-19 pandemic. Two other articles address strategies for dealing with myriad chronic diseases and risk factors in a population. Other papers include in-depth analyses of prostate cancer screening, digital prosthetic services for lower-limb amputees, and the complex behavioral health challenge of youth homelessness.This reprint provides an excellent snapshot of the current state of practice in system dynamics as it is applied to public health, health care delivery, and health policy. It offers practical policy guidance and will be of interest to both experienced practitioners and those new to the field.
    Keywords: simulation model ; public health practice ; chronic disease ; prevention ; cardiovascular diseases ; cancer ; COVID-19 ; tourism recovery ; public policy ; system dynamics ; participatory modelling ; health ; social care ; integrated care ; hospital ; delayed hospital discharges ; strategy ; congestion ; capacity ; archetypes ; unintended consequences ; population health and well-being ; equity ; stewardship ; resilience ; simulation modeling ; uncertainty analysis ; optimization ; sensitivity testing ; Monte Carlo randomization ; opioid epidemic ; prosthetics ; major lower-limb amputations ; prosthesis usage ; amputee mobility ; health care system ; health policy ; youth homelessness ; child welfare ; juvenile justice ; mental health ; public health ; decision making ; long-term conditions ; resource allocation ; complex systems ; early detection of cancer ; mass screening ; decision-making ; dissemination ; clinical practice guidelines ; evidence-based guidelines ; policy decision thresholds ; prostate cancer ; natural history of disease ; biomarker ; PSA ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GP Research and information: general ; thema EDItEUR::P Mathematics and Science
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: A full awareness of the role played by a healthy diet, as part of a healthy lifestyle, in countering or slowing-down chronic and degenerative diseases has strongly increased the interest in food bioactives and the return of ancient foods that are nowadays considered functional. In fact, these dietary substances, to which nutraceutical attributes are increasingly entrusted, could display disease-preventing effects on animals and humans. In this context, polyphenols, which are widespread and mostly copious in dietary plant sources, have gained a lot of attention thanks to their potential ability to halt or reverse oxidative stress-related diseases. Indeed, food could contain, beyond health-promoting compounds, toxicants which are naturally occurring or process-induced dietary compounds with adverse effects on human health. The presence and abundance of bioactives are strictly related to their food source. Edible plant components largely contain beneficial secondary metabolites, but understanding them fully is still an important challenge as complex biotic and abiotic interactions are involved in their biosynthesis. Analytical methods, which are increasingly powerful, could enhance our knowledge of food bioactives, whereas the deep investigation of their bioactivity and bioavailability could make them particularly useful.
    Keywords: Urtica dioica ; natural products bioactivity ; food bioactives ; nutraceuticals ; cancer therapy ; breast cancer ; Aloe vera ; Aloe vera polysaccharides ; in vitro fermentation ; SCFAs ; antioxidant capacity ; food waste recovery ; grape leaves ; UHPLC-HR-MS/MS analysis ; flavonol glycuronides recovery ; linoleic acid peroxidation products ; hexane ; gastric cells ; metabolomics ; cDNA microarray ; avocado ; LC/MS ; fat-soluble vitamins ; carotenoids ; Cannabis sativa L. ; phenylamides ; lignanamides ; hemp seeds ; high resolution tandem mass spectrometry ; U-87 glioblastoma cells ; cytotoxicity ; Pistacia vera ; antioxidant ; quality ; tocopherol ; FTIR ; discriminant analysis ; pistacia (Pistacia vera) hulls ; anticancer ; bacterial resistance ; efflux pumps ; terpenoids ; thymol ; carvacrol ; Rosmarinus officinalis L. ; fresh young shoots tincture ; polyphenols ; terpenes ; hepatoprotective ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: The reprint is devoted to the phenomena associated with exact or approximate axial symmetry in different areas of technical physics and mechanical engineering science. How can the symmetry of the problem be used most efficiently for its analysis? Why is the symmetry broken or why is it still approximately retained? These and other questions are discussed based on systems from different fields of engineering.
    Keywords: fretting wear ; axis-symmetry ; tangential contact ; torsional contact ; Abel transform ; injection molding ; concentricity ; coaxiality ; optical barrel ; bilateral telecentric lens ; optimization ; contact problem ; non-axisymmetric indenter ; extremal principle ; generalized MDR ; non-axisymmetric ; circular contact ; frictionless contact ; general solution ; closed-form solution ; series solution ; cylindrical punch ; contact stress-intensity factor ; cylindrical symmetry ; spherical symmetry ; periodic boundary conditions ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.
    Keywords: HCV ; esophageal cancer ; male ; interferon ; mortality ; colorectal cancer ; gynecologic cancer ; retrospective cohort study ; colonoscopy screening ; gastric cancer ; ascites ; postoperative follow-up ; gastrectomy ; endoscopic submucosal dissection ; early gastric cancer ; type 2 diabetes mellitus ; glycemic control ; insulin resistance ; hepatocellular carcinoma ; annexin A2 ; prognostic marker ; survival outcome ; biliary tract cancer ; circulating tumor cell ; vimentin ; diagnosis ; prognosis ; gastric xanthelasma ; synchronous/metachronous gastric cancer ; genetic alteration ; predicting marker ; interval cancer ; screening ; endoscopy ; national cancer screening program ; c-Myc ; genetic linkage analysis ; cigarette smoking ; survival ; CRC ; CCL2 ; CCL4 ; CCL15 ; diagnostic utility ; gastrointestinal malignancies ; cancer survivorship ; calcium carbonate ; hypercalcemia ; cancer outcomes ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: This reprint examines regulatory, pricing and reimbursement issues related to the market access and uptake of off-patent biologics, biosimilars, next-generation biologics and competing innovative medicines in European countries.
    Keywords: infliximab ; etanercept ; TNFα inhibitors ; biologics ; biosimilars ; Germany ; policies ; incentives ; uptake ; market dynamics ; biosimilar market ; biosimilar/supply and distribution ; biosimilar sustainability ; Delphi technique ; pricing ; reimbursement ; utilization ; biosimilar ; biological ; information ; education ; communication ; patient ; Europe ; adalimumab ; biosimilarity assessment ; quality attributes (QAs) ; potentially critical quality attributes (pCQAs) ; European public assessment reports (EPARs) ; clinical governance ; Spain ; barriers ; regulatory ; review ; approval ; clinical ; queries ; regulatory science ; budget impact analysis ; savings ; pharmaceutical spending ; cost containment ; reference biological ; competitive market ; Belgium ; trastuzumab ; intravenous ; subcutaneous ; HER2-positive breast cancer ; drug costs ; healthcare costs ; cost simulation ; tender ; procurement ; off-patent ; award criteria ; switching ; interchangeability ; sustainability ; competition ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Researchers have made great progress in the mechanism of mycotoxins biosynthesis, pathogenicity, and the construction of detection methods. This collection holds fundamental and applied research on pathogenic fungi and mycotoxins in China, which directly or indirectly affect the health of plants, animals, and humans. Some papers mainly study the mechanism of mycotoxin biosynthesis, including the crucial genes, environmental factors, and regulation mechanisms, which is beneficial to advancing our knowledge of this area. Some papers focus on the toxicity of mycotoxins, which is helpful to the detoxification of mycotoxins and the reduction of the hazardous effect of mycotoxins. Special attention is given to the leading detection methods, especially on-site rapid detection. These effective and feasible methods are important for discovering and controlling the risk of mycotoxins.
    Keywords: water activity ; aflatoxin biosynthesis ; conidia development ; regulatory mechanism ; AtfB ; fumonisin B1 ; BALB/c mice ; fecal bacterial flora ; 16S rRNA sequencing ; zearalenone ; gilts ; ovary ; hormone ; weaned gilt ; intestinal morphology ; ghrelin ; PCNA ; farmers’ grain storage silos ; absolute water potential ; ventilation and drying ; mycotoxins ; contamination distribution ; Alternaria toxins ; modified QuEChERS method ; ultra-high-performance liquid chromatography-tandem mass spectrometry ; mixed fruit puree ; Aspergillus flavus ; AflN ; aflatoxin ; conidiation ; rice false smut ; ustiloxins ; generic antigen ; immuno-magnetic beads ; enzyme-linked immunity ; hepatotoxicity ; nephrotoxicity ; haematological toxicity ; regulatory limit ; αB-conotoxin VxXXIVA ; epitope ; hybridoma ; monoclonal antibody ; ELISA ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 80
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-11-30
    Description: This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies.
    Keywords: Postoperative pain ; Chronic postoperative pain ; Pain mechanisms ; Postoperative pain management ; Physiopathology of chronic postoperative pain ; Opioids ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 81
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: The great economic and strategic importance of catalysis makes it a rapidly evolving field. Catalysis is fundamental in areas such as sustainable development, energy production, environmental protection, food production, and water purification. In the face of the significant challenges of the present day, acquiring fundamental knowledge about the structure and phenomena on the surface of catalysts and the relationships between the composition, synthesis method, properties, and performance of catalysts in industrial processes is essential. Research is still needed to improve existing catalysts or design new systems which may efficiently and selectively conduct a given reaction toward the desired product. This Special Issue was devoted to designing and characterizing heterogeneous catalytic systems for industrial chemical processes. The reprint collects 10 research articles providing insight into important aspects of modern catalyst design. The papers cover recent advances and comprehensive experimental studies of synthesis, characterization, and evaluation of catalyst performance in the following processes: ammonia synthesis, selective catalytic reduction of nitrogen oxides, hydrogen production from ethanol, and photocatalysis.
    Keywords: cobalt molybdenum nitrides ; ammonia synthesis ; phase composition ; specific surface area ; cobalt catalyst ; barium ; promoter ; optimization ; hydrogen ; ethanol ; catalyst ; TiO2 photocatalysis ; UV-C ; photolysis ; ammonia ; nitrogen removal ; water treatment ; hydrogen production ; ethanol steam reforming ; nickel-based catalyst ; manganese oxides ; potassium promoter ; gliding discharge ; plasma–catalytic system ; tar decomposition ; nickel catalyst ; nitric acid plant ; selective catalytic reduction ; clinoptilolite ; iron-modified zeolite catalyst ; TiO2-SiO2 ; mesoporous ; F127 ; high surface area ; solar photocatalysis ; dye degradation ; structure sensitivity ; size effect ; carbon support ; neodymium oxide ; support ; hydrogen poisoning ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 82
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The second volume of the Special Issue on “Micro-Electro Discharge Machining: Principles, Recent Advancements and Applications” confirms the growing interest in the micro-EDM technology as a suitable and efficient technology for machining novel, multilateral components, with demanding requirements in terms of precision, accuracy, and productivity.This volume consists of 10 original research papers which involve several approaches to micro-EDM and cover the enhancement of the process performance, such as the material removal rate, surface roughness, or machining accuracy, using advanced optimization methods. Some studies also consider several dielectric fluid additives and investigate the processability of new materials. Others investigate the combination of Reverse-micro-EDM with laser beam micromachining or explore new applications for the micro-EDM for fabricating antimicrobial nanosilver colloid.
    Keywords: electrical discharge machining ; metal matrix composite ; Taguchi ; micro-hardness ; surface roughness ; material removal rate ; wire electro-discharge machining ; polymer composite materials ; processing precision ; interelectrode gap ; micro-EDM milling ; accumulative difference ; material removal ; tool electrode wear ; analytical hierarchy process ; residual stress ; metal erosion rate ; Reverse-μEDM ; Nd: YAG LBµM ; micro-holes ; burrs ; protrusions ; electrical discharge machine ; energy consumption ; nanosilver colloid ; antimicrobial ; micro-EDM ; tungsten carbide ; carbon nanofiber ; silicon ; alumina ; shape memory alloys ; nitinol ; optimization ; near-dry wire electric discharge machining (WEDM) ; teaching–learning based optimization (TLBO) algorithm ; micro electrical discharge machining ; vibration assisted electrical discharge machining (EDM) ; high-speed camera ; array electrode ; structured surface ; efficiency ; micromachining ; performance ; quality ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 83
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: The development of in vivo neuroimaging techniques has yielded an incredible amount of digital information about the brain. Neuroimaging techniques are increasingly being used to study human cognitive processes, create brain–machine interfaces, and also to identify and diagnose certain brain disorders. Currently, neuroscientists and medics actively use different methods for brain scans, including electro- and magnetoencephalography (EEG/MEG), functional near-infrared spectroscopy (fNIRS), electrocorticography (ECoG), functional magnetic resonance imaging (fMRI), positron emission tomography (PET), and diffusion tensor imaging (DTI). Recent advances in signal processing and machine learning for neuroimaging data using various signal processing methods have made impressive progress in solving a number of practical tasks in medicine, healthcare, neuroscience, biomedical engineering, brain–machine interfaces, and cognitive science, to name but a few. This Special Issue aims to provide a forum for academic and industrial communities to present and discuss the latest theoretical and experimental results related to recent advances in neuroimaging data processing in terms of new theories, algorithms, architectures, and applications.
    Keywords: MEG ; FieldTrip ; Brainstorm ; source reconstruction ; flickering ; cognitive neuroscience ; visual perception ; detrended fluctuation analysis ; long-range correlations ; electroencephalogram ; sleep deprivation ; nonstationarity ; transfer entropy ; kernel methods ; Renyi’s entropy ; connectivity analysis ; phase interactions ; brain data ; low-cost devices ; EEG ; BIDS ; neuroscience ; library ; ambiguous stimuli ; Necker cubes ; classification task ; EEG analysis ; wavelet analysis ; decision time ; perceptual errors ; time-on-task effect ; brain connectivity ; artificial neural networks ; granger causality ; time series ; brain–computer interface ; event-related potential ; beamforming ; regularization ; BCI ; graphical user interface ; wheelchair navigation ; grid map ; natural landmark ; optimal paths ; deep Q-networks ; focal epilepsy ; diffusion imaging ; electroencephalography ; structure-function coupling ; seizure onset ; structural connectivity ; functional connectivity ; cognitive load ; coupling ; bubble entropy ; transition network ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: Non-destructive testing and evaluation are commonly referred to as the vast group of analysis techniques used in civil, medical, and industrial sectors to evaluate the properties of materials, tissues, components, or structures, without causing any damage. Automation offers many benefits for non-destructive testing to cope with increasing demands, including improved reliability and higher inspection speeds. Additionally, robots enable inspections in locations that are not easily accessible to human operators and allow for humans to be removed from potentially dangerous environments. However, the perceived complexity and high costs have limited the adoption of automation. As a result, the full potential that could be derived from the seamless integration of robotic platforms with sensors, actuators, and software has not been fully explored; it could still revolutionise the way that automated inspections are performed and conceived. The recent advancements in electronics, robotics, sensor technology and software pave the way for new developments in automated testing and data-driven autonomous robotic inspections in several sectors. This Special Issue aimed to attract the latest research outcomes in the field of robotic sensing. Five papers relate to inspection systems based on robotic fixed-base manipulators, three of which are associated with in-process inspection in manufacturing applications (robotic wire-arc welding and additive manufacturing). Four papers report research advancements in mobile robotic-enabled sensing.
    Keywords: wall-climbing robot ; passive adaptive mechanism ; magnetic circuit optimization ; flexible detection method ; welding robot ; seam tracking ; laser sensor ; feature point extracting ; complex welding seam ; UAVs ; inspection ; soft robotics ; non-destructive evaluation ; robotic NDE ; robotic welding ; robotic control ; in-process NDE ; ultrasonic NDE ; ultrasound ; image motion analysis ; image processing ; optical flow ; underwater robotic ; NDT ; free-form surface profiling ; autonomous robotic systems ; in-process robotic NDE ; Wire + Arc Additive Manufacture (WAAM) ; ultrasound testing ; total focusing method ; defect recognition ; aircraft inspection ; deep learning ; CNN ; UAV ; defect classification ; AI ; underwater vehicle–manipulator system ; robotics emulator ; contact management ; remote inspection ; force control ; automated eddy current testing ; eddy current arrays ; robotics ; thermography ; non-destructive testing ; image alignment ; image blending ; n/a ; bic Book Industry Communication::M Medicine
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The year 2021 marks the 10th anniversary of Journal of Clinical Medicine, and as one of the major sections of JCM, we are launching a 10th anniversary Special Issue in the section “Gastroenterology & Hepatopancreatobiliary Medicine”. We accepted papers for the Special Issue, titled "Recent diagnostic and therapeutic advance in Gastroenterology & Hepatopancreatobiliary Medicine". This medical field is a complex and wide-ranging field that deals with diseases in multiple organs such as the gastrointestinal tract and hepatobiliary pancreas. With recent advances in diagnostic imaging and interventional treatment, those in endoscopic diagnosis and treatment, those in functional test and those in genetic diagnosis and drug therapy, including the molecular-targeted therapy, many new medical findings have been accumulated. In this Special Issue, we looked for reports that make full use of advances in diagnostics and therapeutics in the field of Gastroenterology and Hepatopancreatobiliary Medicine.
    Keywords: TXI ; sessile serrated lesion ; hyperplastic polyp ; colonoscopy ; endoscopic submucosal dissection ; colorectal tumor ; traction method ; carbon dioxide ; CO2 insufflation ; abdominal pain ; abdominal distention ; transnasal endoscopy ; health check ; tranexamic acid ; gastrointestinal bleeding ; mortality ; thromboembolic events ; liver metastases ; colorectal liver metastases ; non-colorectal and non-neuroendocrine liver metastases ; liver resection ; Crohn’s disease ; biologics ; small-molecule drugs ; health-related quality of life (HRQoL) ; gastric cancer ; gastric cancer screening ; endoscopy ; H. pylori ; eradication therapy ; n/a ; functional bowel disorders ; gut microbiota ; personalized diet ; machine learning ; personalized medicine ; Turkey ; machine perfusion ; normothermic ; hypothermic ; liver transplant ; survival ; ustekinumab ; perianal fistula ; radiological fistula remission ; metastatic pancreatic carcinoma ; FOLFIRINOX ; sarcopenia ; oxaliplatin ; L3 skeletal muscle index ; percutaneous endoscopic gastrostomy ; prognostic factor ; bic Book Industry Communication::M Medicine
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Ciguatoxins (CTXs), which are responsible for Ciguatera fish poisoning (CFP), are liposoluble toxins produced by microalgae of the genera Gambierdiscus and Fukuyoa. This book presents 18 scientific papers that offer new information and scientific evidence on: (i) CTX occurrence in aquatic environments, with an emphasis on edible aquatic organisms; (ii) analysis methods for the determination of CTXs; (iii) advances in research on CTX-producing organisms; (iv) environmental factors involved in the presence of CTXs; and (v) the assessment of public health risks related to the presence of CTXs, as well as risk management and mitigation strategies.
    Keywords: ciguatoxins ; HRMS ; Q-TOF ; ciguatera poisoning ; C-CTX1 ; fragmentation pathways ; maitotoxins ; Gambierdiscus ; Fukuyoa ; LC-MS/MS ; QToF ; neuroblastoma cell assay ; matrix effect ; ciguatera monitoring ; SPATT passive samplers ; HP20 resin ; CBA-N2a ; WS artificial substrate ; qPCR ; HTS metabarcoding ; ciguatera ; ciguatoxin ; cytotoxicity assay ; ELISA ; HPLC ; immunoassay ; mouse bioassay ; receptor-binding assay ; ciguatoxins (CTXs) ; neuroblastoma cell-based assay (CBA) ; immunosensor ; pacific ciguatoxins ; natural product ; polycyclic ether ; ring-closing metathesis ; Tsuji-Trost allylation ; French Polynesia ; epidemiology ; toxicological analyses ; risk management ; climate change ; Gambierdiscus polynesiensis ; toxin profile ; nitrate ; urea ; culture medium acidification ; CTX1B ; 52-epi-54-deoxyCTX1B ; 54-deoxyCTX1B ; Dictyota ; Caribbean ; dinoflagellate ; benthic algae ; algal toxin ; harmful algal bloom ; the Indian Ocean ; Arabian sea ; Kuwait bay ; Aden Gulf ; Red Sea ; Gulf of Aqaba ; Andaman Sea ; Bay of Bengal ; seafood safety ; foodborne disease ; experimental exposure ; lionfish ; trophic transfer ; toxin accumulation ; Selvagens Islands ; morphology ; phylogeny ; benthic dinoflagellate ; Beibu Gulf ; Chinese waters ; least absolute shrinkage and selection operator ; machine learning ; data science ; medical informatics ; survival analysis ; foodborne diseases ; Ciguatera Fish Poisoning ; digital technologies ; open data ; risk analysis ; marine biotoxins ; Lagodon rhomboides ; pinfish ; bioaccumulation ; depuration ; Caribbean ciguatoxin ; growth dilution ; model ; kinetics ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: Billions of people suffer from dental problems. Paradoxically, the deteriorating state of teeth is accompanied by the ever-increasing desire to preserve the best facial appearance, which is significantly influenced by teeth aesthetics. This favors the development of dental materials and manufacturing technologies for dental prosthetics, needed to achieve expected effects of clinical treatment.This reprint focus on enhancing antimicrobial and mechanical properties of polymeric materials and composites for dentistry. In recent years, special attention has been focused on the possibility of giving materials new or improved properties by the introduction of nano or submicron size additives, fibers or whiskers. Using agents such as natural oils to enhance antimicrobial properties remains an exciting idea. Another area of research is the application of antibacterial monomers, which can be copolymerized in resins to kill oral pathogenic microflora. The use of new monomers or new compilations of various monomers to improve mechanical properties has also aroused interest. In addition, we are currently looking for new data regarding colonization of dental materials by pathogenic microbes and their influence on the other properties. Further, there are many new commercially available materials which should be investigated to verify their properties, which is important from the point of view of clinical practice. Original new research and reviews related to any of the topics mentioned above indicate the current directions of development of dental materials. We hope that the presented work will be of interest to readers.
    Keywords: dental cements ; ethanol ; water ; resistance ; DTS ; Vickers hardness ; dental materials ; dimethacrylates ; polymer networks ; structure ; morphology ; degree of conversion ; crosslink density ; physical crosslinking ; hydrogen bonds ; mechanical properties ; water sorption ; polymethyl methacrylate ; denture ; antibacterial properties ; silver ; sorption ; solubility ; wear resistance ; FRC ; bonding ; technique ; fiber ; reinforced ; composite ; spot ; mechanical ; deflection ; orthodontics ; brushing ; wear ; retainer ; splint ; load ; direct pulp capping ; indirect pulp capping ; ProRoot MTA ; MTA Angelus ; retroMTA ; biodentine ; theraCal LC ; ACTIVA BioACTIVE ; vital pulp therapy ; glass fiber ; composite post ; endodontic therapy ; etching ; post and core technique ; silane ; glass-ionomer cements ; resin-modified ; fibre ; reinforcement ; nanoparticles ; testing ; strength ; P2O5-bioglass ; zirconia ; melt-quenching ; SBF ; hydroxyapatite ; in vitro bioactivity ; essential oils ; oral pathogens ; antibacterial activity ; S. mutans ; L. acidophilus ; C. albicans ; antifungal activity ; resin composite ; wettability ; biofilm formation ; cytotoxicity ; polymers ; antimicrobial properties ; infiltrants ; metronidazole ; dental ceramics ; spectroscopy ; IR ; FT-IR ; Raman spectroscopy ; UV-Vis ; X-ray spectroscopy ; XRF ; XRD ; MS ; dental resins ; UDMA ; Bis-GMA ; Bis-EMA ; TEGDMA ; hardness ; water absorption ; water dissolution ; CAD-CAM ; inlay ; lithium disilicate ; zirconium dioxide ; root caries ; infiltration ; microstomatology ; adhesive ; bracket ; dentures ; denture adhesives ; human fibroblasts ; composite resins ; Streptococcus mutans ; dental caries ; bacterial adhesion ; oleic acid ; PMMA ; filamentation ; biofilm ; antimicrobial surface ; Candida albicans ; colonization ; penetration ; dimethacrylate copolymers ; quaternary ammonium methacrylates ; urethane-dimethacrylates ; photocurable copolymers ; water behavior ; thermoplastic materials ; laboratory protocol ; texture ; roughness ; biomaterial ; polymer ; microbial degradation ; artificial saliva ; mucins ; n/a ; bic Book Industry Communication::M Medicine
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  • 88
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-07-14
    Description: In this Special Issue, we sought advanced knowledge in both basic and clinical research presented in original articles and comprehensive reviews highlighting the latest advances in MCC. Articles focus on but were not restricted to the molecular basis of the disease, translational investigations of biomarkers for prospective clinical applications, and innovative diagnostic and therapeutic approaches in MCC.
    Keywords: miR-375 ; antagomiRs ; Merkel cell carcinoma ; Hippo signaling ; focal adhesion ; diagnosis ; treatment ; review ; guideline ; Merkel cell polyoma virus ; tumor microenvironment ; CD8 lymphocytes ; ulceration ; E-cadherin ; artesunate ; MCC ; polyomavirus ; ferroptosis ; radiation therapy ; immunotherapy ; surgical intervention ; survival ; multidisciplinary communication ; biomarkers ; cell tropism ; signaling pathways ; therapy ; transgenic mice ; tumorigenesis ; histogenesis ; ATOH1 ; GLI1 ; sonic hedgehog ; hair follicle ; Merkel cell polyomavirus ; skin carcinogenesis ; T antigens ; human polyomaviruses ; DNA tumor viruses ; viral oncoproteins ; merkel cell carcinoma ; merkel cell polyoma virus ; sex ; radiotherapy ; UV ; cell line ; MYC ; TP53 ; RB1 ; whole-exome ; significantly mutated genes ; copy number variation ; virus positive Merkel cell carcinoma ; virus negative Merkel cell carcinoma and copy number variant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-06-23
    Description: In the treatment of acute stroke, thrombolysis and thrombectomy have proven to be highly effective. Many patients have seen significant improvement after reperfusion therapy. This reprint aims to address current knowledge gaps and promote advancements in the use of thrombolysis and thrombectomy for the treatment of acute ischemic stroke.
    Keywords: ischemic stroke ; acute kidney injury ; contrast media ; endovascular treatment ; outcome ; hyperglycemia ; acute ischemic stroke ; large vessel occlusion ; mechanical thrombectomy ; stroke ; ischemia ; machine learning ; cerebral infarction ; biomarkers ; recanalization therapy ; reperfusion ; temperature ; time to admission ; prehospital delay ; prior stroke ; basilar artery ; brain ischemia ; intracranial atherosclerosis ; embolism ; infarction ; clinical symptoms ; intravenous thrombolysis ; endovascular therapy ; recanalization times ; clinical outcome ; hypoperfusion index ratio ; collateral circulation ; collateral scoring ; CTA ; CTP ; thrombolysis ; C-reactive protein ; white blood cell count ; prognosis ; hypoperfusion ; collaterality ; thrombectomy ; frailty ; elderly patients ; hospital frailty risk score ; acute stroke ; perfusion imaging ; CT perfusion ; MR perfusion ; RAPID ; fasting hyperglycemia ; fasting normoglycemia ; long-term outcome ; hemorrhagic transformation ; parenchymal hematoma ; GWAS ; single nucleotide variants ; anterior circulation ; bridging therapy ; recanalization ; stroke risk score ; COVID-19 ; Lithuania ; reperfusion therapies ; outcomes ; safety ; prehospital stroke diagnosis ; ultrasound ; brain perfusion ; SONAS® ; prehospital stroke scales ; point-of-care diagnostics ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: As Editor-in-Chief of the journal Diabetology, I am pleased to announce that the Special Issue “Diabetology: Feature Papers 2022” has now been published as a reprint. Diabetology (ISSN 2673-4540) is an international, peer-reviewed scientific open access journal that provides an advanced forum for studies related to the epidemiology, etiology, pathophysiology, pathogenesis, management, complications, and prevention of diabetes, including the molecular, biochemical, and physiological aspects of diabetes. In this Special Issue, “Feature Papers”, we aimed to publish outstanding contributions in the main fields covered by the journal, which will make a great contribution to the community. This reprint covers the whole spectrum of diabetology from risk screening, risk markers, pathways of disease in type 1 diabetes and insulin treatment, and management of the disease and comorbidities.
    Keywords: older people ; diabetes mellitus ; management ; insulin therapy ; frailty ; sarcopenia ; type 1 diabetes ; type 2 diabetes ; insulin ; beta cell preservation ; verapamil ; thioredoxin-interacting protein (TXNIP) ; Chronic Care Model ; self-management of type 2 diabetes ; chronic disease ; healthcare system of Pakistan ; patients’ quality of life ; obstructive sleep apnoea ; DM ; obesity ; inflammation ; polysomnography ; coronavirus disease 2019 ; COVID-19 ; severe acute respiratory syndrome coronavirus 2 ; SARS-CoV-2 ; diabetes ; diabetic ketoacidosis ; DKA ; hyperglycemia ; mortality ; innate immunity ; cytokine storm ; angiotensin-converting enzyme 2 ; pancreatic β-cell damage ; pediatrics ; HbA1c ; telemedicine ; continuous glucose monitoring ; prediabetes ; liver enzymes ; rhenium (V) compound ; triglycerides ; NAFLD ; fructose ; injection technique ; lipohypertrophy ; sodium glucose co-transporter 2 (SGLT2) inhibitors ; nocturia ; sodium intake ; key informant interviews ; prevention of type 2 diabetes ; National DPP ; DSMES ; telehealth ; provider experiences ; lipodystrophy ; clinical detection ; recommendations ; rehabilitation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: Electronic cigarettes (ECs) have been present on the consumer market for over a decade, and the number of related scientific publications in the PubMed database has now exceeded seven thousand. Despite the number of publications, there is still no consensus in the scientific community regarding their safety. However, it should be emphasized that a comparison of equivalent quantities of tobacco smoke and the aerosol produced from e-cigarettes showed that there was a significantly lower quantity of toxic compounds in the aerosol compared with the tobacco smoke. Therefore, the use of ECs could be seen as a way of reducing the health damage to cigarette smokers who cannot or are unwilling to quit using conventional methods. In addition, randomized studies are emerging suggesting that ECs could be useful in smoking cessation. On the other hand, ECs are now widely used among adolescents and may pose a serious risk of future nicotine dependence and health problems in this population, as they counteract their advantages in the population gained from smokers who quit using them. Therefore, as most authors stress, further research that will convincingly resolve the current controversies is needed. Clinicians urgently need evidence-based knowledge to better inform their patients about the use of these emerging tobacco products as a harm-reduction strategy, and regulators should regulate these products in ways that best serve public health, especially taking the youth population into account.
    Keywords: e-cigarettes ; global health ; vaping ; tobacco smoke ; toxicants ; cessation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-01-05
    Description: In the last century, the average life expectancy at birth increased from roughly 45 years in the early 1900s to more than 80 years of age at present. However, living longer is often related to different levels of frailty. There is no curative treatment for frailty—the interventions that have been described as effective to slow or delay the onset of frailty are physical activity and nutritional interventions. Maintaining adequate nutrition status is important to reduce the risk of chronic diseases, many of which are age-related. On the other hand, frailty itself may have a negative effect on eating and, thus, on the nutritional status. This Special Issue, "Nutrition, Diet Quality, Aging and Frailty", addresses the existing knowledge on nutrition regarding the causative factors of frailty and disease due to aging, i.e., strategies for delaying the pathological effects of aging. It consists of twelve peer-reviewed papers covering original research, protocol development, methodological studies, narrative or systematic reviews, and meta-analyses, to better understand these complex relationships.
    Keywords: diet ; metabolism ; nutrient ; glucose ; lipid ; insulin ; neuroinflammation ; Alzheimer’s disease ; anti-ageing ; eating habits ; functional foods ; skin ageing ; breakfast ; meals ; older adults ; protein intake ; hyperhomocysteinemia ; vitamin B deficiency ; amyloid beta-peptides ; disease models ; animal ; memory and learning tests ; dietary diversity ; activities of daily living ; cohort study ; adults ; mortality ; QOL ; ADL ; Serum albumin ; self-assessed chewing ability ; inflammaging ; cognitive impairment ; cytokines ; physical frailty ; aged ; dietary inflammatory index ; dietary patterns ; frailty ; inflammation ; muscle function ; muscle mass ; sarcopenia ; prevalence ; nutrition ; physical activity ; meta-analysis ; meta-regression ; dairy products ; dietary pattern ; malnutrition ; food groups ; Mediterranean dietary pattern ; Westernized dietary pattern ; cross-sectional study ; aging ; lifespan ; carbohydrates ; whole grain ; protein ; bic Book Industry Communication::M Medicine
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-02
    Description: Essential hypertension is still an important health care problem. It is necessary to investigate its mechanisms in animal models. The potential clinical importance of such experimental research might be expected. This Special Issue concerned several important topics. First, several studies focused on the pathophysiological mechanisms responsible for blood pressure elevation during hypertension development, organ damage in chronic hypertension, and drugs targeting hypertension and/or its complications. Other studies were interested in the participation of central and peripheral blood pressure control, changes in vascular structure and function, and neural, humoral, and endocrine factors. Furthermore, the contribution of altered redox signaling, chronic inflammation, microbiome changes, and interactions of genetic and environmental factors were evaluated in multiple papers. Finally, special attention was paid to the progress in pharmacological tools for the control of hypertension and associated organ damage, genetic modifications to alter blood pressure levels, and non-pharmacological interventions attenuating hypertension or its complications. The original articles or reviews covered the interesting aspects of the pathophysiology of hypertension and associated end-organ damage, the use of various experimental hypertensive models, and the importance of specific environmental factors acting in distinct phases of the ontogeny. We especially appreciate the presentation of new ideas and the critical discussion of traditional theories.
    Keywords: developmental origins of health and disease (DOHaD) ; gut microbiota ; hypertension ; short chain fatty acid ; oxidative stress ; probiotics ; prebiotics ; renin–angiotensin system ; fibroblast growth factor-23 ; left ventricular hypertrophy ; renin–angiotensin–aldosterone system ; losartan ; canrenone ; Hyp mice ; X-linked hypophosphatemia ; hairless SHRM ; cold acclimation ; cardiac Cx43 ; extracellular matrix ; thyroid hormones ; SHR ; sacubitril/valsartan ; ARNI ; ivabradine ; remodelling ; cardiac dysfunction ; fibrosis ; angiotensin II ; angiotensin 1-7 ; knock-out ; genome-editing ; SHRSP ; Dahl SS ; foetal programming of hypertension ; sympathetic neurotransmission ; sympathetic innervation ; vascular remodelling ; foetal undernutrition ; old SHR ; antihypertensive therapy ; blood pressure monitoring ; LV hypertrophy ; ECM markers ; cardiac fibrosis ; SHR-CRP ; SGLT-2 inhibitor ; gene expression ; age ; lipid metabolism ; nitric oxide ; l-NAME ; rostral ventrolateral medulla ; aging ; reactive oxygen species ; NADPH oxidase activator 1 ; mitochondria ; chloride ; calcium-activated chloride channel ; Na+–K+–2Cl− cotransporter 1 ; TMEM16A ; smooth muscle ; fetal undernutrition programming ; cross-fostering ; lactation period ; cardiovascular hypertrophy ; adipose tissue browning ; cardiovascular disease ; catecholamines ; liquid chromatography–tandem mass spectrometry ; SGLT-2 inhibition ; proteinuria ; uninephrectomized salt-loaded ; two-kidney ; one-clip hypertension ; fawn-hooded hypertensive rat ; ApoE KO ; apolipoprotein E knockout mice ; atherosclerosis ; Na,K-ATPase ; TCTP ; TCTP-overexpressing transgenic mice ; translationally controlled tumor protein ; TCTP-TG ; experimental hypertension ; bone ; rats ; taurine ; magnesium ; 24 h urine(24U) ; stroke-prone spontaneously hypertensive rat ; young SHR ; combination therapy ; treatment effect ; systolic blood pressure ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint aims to promote and disseminate applied research in the field of corrosion of steel structures and technological equipment. Within the text, the focus is firmly placed on the detailed study of corrosion processes affected by specific environments, as well as on the effects of corrosion damage on the reliability and service life of structural components and technological equipment. Special attention is paid to the study of the impact of corrosion processes on pipelines.
    Keywords: Q235B steel ; desulfurization solution ; corrosion mechanism ; pitting corrosion ; high pressure and high temperature ; O2–CO2 coexistence environment ; flow-induced corrosion ; reinforcing steel ; corrosion ; chloride ; experiment ; bow shaped device ; concrete ; cathodic protection ; buried pipelines ; rust layer ; electrochemical acceleration test ; applied current density ; required current ; low-alloy steel ; SEM ; inclusion ; anodic dissolution ; steel pipeline ; in-line inspection results ; interacting corrosion defects ; structural integrity ; galvanostatic test method ; underground infrastructure ; long-term corrosion ; carbon steel ; ASTM A516-65 steel ; weld ; hydrogen-induced cracking ; galvanic corrosion ; sour environment ; vinyltrimethoxysilane ; silane ; sol–gel ; response surface methodology ; Box–Behnken design ; modeling ; soil environment ; carbon steel corrosion ; stray current corrosion ; pipeline ; calcareous deposit ; corrosion mitigation ; failure analysis ; low-carbon steel pipe ; aluminum inclusions ; pearlite inhomogeneity ; steel structures ; crevice corrosion ; lattice towers ; bolted lap joints ; weathering steel ; experimental tests ; numerical modelling ; corrosion current density ; sulfate ; galvanized steel ; alkaline solutions ; linear polarization resistance ; electrochemical impedance spectroscopy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 95
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: The challenges in identifying effective therapies for CNS tumors continue to be daunting. Potentially effective targeted therapies must be able to penetrate the blood–brain barrier to reach the tumor and, in sufficient concentrations, to result in meaningful treatment responses. Moreover, molecular targets must be key drivers in the growth and progression of CNS tumors. Numerous potentially efficacious therapies have failed in randomized clinical trials due to other factors, including subclonal genetic intratumoral heterogeneity (particularly within malignant gliomas), epigenetic heterogeneity, and failure to target important factors involved in the tumor microenvironment. Developing effective targeted therapies requires a thorough fundamental understanding of the genetic and epigenetic factors driving tumor progression, the interactions between CNS tumor cells and the tumor microenvironment, and the key mechanisms of tumor treatment resistance. In this Special Issue, experts in the field of CNS tumors will highlight the most promising molecular targets in the development of treatments for patients with CNS tumors.
    Keywords: glioblastoma molecular classification ; ERK/MAPK pathway ; PI3K/PTEN pathway ; receptor tyrosine kinase ; EGFR ; PDGFRA ; FGFR3 ; MET ; EPHB2 ; NF1 ; immunotherapy ; glioblastoma ; blood–brain barrier ; central nervous system ; T cells ; T lymphocytes ; PCNSL ; CNS lymphoma ; methotrexate ; novel therapies ; novel therapeutics ; neurofibromatosis ; low grade glioma ; plexiform neurofibroma ; vestibular schwannoma ; glioma ; tumor mutation burden ; neoantigen ; immune score ; germline mutation ; antigen processing and presentation ; ependymoma ; subependymoma ; RELA ; YAP1 ; ZFTA ; PFA ; PFB ; MYCN ; Group A ; Group B ; myxopapillary ; targeted therapy ; diffuse midline gliomas ; molecular targets ; potential therapy development ; intraparenchymal metastases ; CNS disease ; metastatic disease ; tyrosine kinase inhibitors ; monoclonal antibodies ; Warburg effect ; mass spectrometry ; isotope labeling ; cancer metabolism ; pediatric brain tumor ; adenosine ; tumor microenvironment ; A2AAR antagonist ; immune evasion ; adenosine receptors ; bevacizumab ; temozolomide ; progression ; biomarker ; neoplastic ; meningitis ; leptomeningeal ; chemotherapy ; radiotherapy ; intrathecal ; GBM ; U87MG ; A172 ; Metformin ; LPS ; antioxidant ; cell cycle arrest ; apoptosis ; low-grade glioma ; preclinical models ; IDH-mutant glioma ; patient avatars ; methylation ; methylomics ; G-CIMP ; MGMT ; DNMT ; ATRX ; H3K27M ; CpG island ; tumor suppressor ; methyltransferases ; histone acetylation ; brain tumor ; brain metastasis ; lung cancer ; lung malignancy ; progression-free survival ; epidermal growth factor receptor ; lung carcinoma ; molecular therapy ; whole-brain radiation therapy ; stereotactic radiosurgery ; KIF11 ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-09-11
    Description: Humans and animals are continuously exposed to different unwanted actions of compounds, including mycotoxins present in food, water, and air. The presence of mycotoxins is a reason for different disease states or tissue and organism dysfunction. New work should facilitate a more accurate description of the degree of species sensitivity and more efficient dietary management, using environmental influences to improve plant material and animal health quality during primary production. On the other hand, better knowledge of the different forms of enzymes participating in mycotoxin biotransformation would enable more efficient preventive and therapeutic actions in many disease states in which the aetiology was not fully understood until now.
    Keywords: zearalenone ; digestive tract ; carryover factor ; ERs mRNA ; CYP1A1 mRNA ; GSTP1 mRNA ; pre-pubertal gilts ; low doses ; carry-over ; myocardium ; vascular reactivity ; mastitis ; ovarian cysts ; pyometra ; hepatic portal system ; dairy cows ; biosensors ; deoxynivalenol ; immunosensors ; feed ; antibody ; aptamer ; molecularly imprinted polymer ; low dose ; bone marrow microenvironment ; haematology ; AMH ; cattle ; long-term monitoring ; sub-clinical contamination ; SAA ; urine ; intestines ; CYP1A1 and GSTπ1 ; prepubertal gilts ; amoxicillin ; doxycycline ; Ussing chamber ; swine jejunum mucosa explants ; gonads ; hypothalamus ; pituitary gland ; steroid hormones ; immunohistochemistry ; oestrogen receptors ; gilts before puberty ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-03-07
    Description: This reprint, entitled “Process Control and Smart Manufacturing for Industry 4.0”, contains the extended papers from the Series of annual IFSA conferences on Automation, Robotics and Communications for Industry 4.0/5.0 (ARCI) on the following topics: Process Automation, Process Control and Monitoring, Design Principles in Industry 4.0, Smart Manufacturing and Technologies, Smart Factories, Machine Learning and Artificial Intelligence in Manufacturing. The reprint contains 13 chapters written by 54 ARCI conference participants from seven countries: China, Croatia, Denmark, Germany, Italy, Poland and Romania. This reprint will inform readers of cutting-edge developments in the field and provide effective starting points and a road map for further research and development. All chapters follow the same structure: firstly, an introduction to the specific topic under study; secondly, a description of the field, including sensing or/and measuring applications. Each chapter ends with a curated list of references, including books, journals, conference proceedings and websites. “Process Control and Smart Manufacturing for Industry 4.0” is intended for researchers and scientists from academia and industry, as well as for postgraduate students.
    Keywords: steel alloys ; resistance spot welding ; RSW ; electrode wear ; electrode tip-dressing ; process monitoring ; mushrooming ; plateau forming ; quality control ; COVID-19 ; FDM ; 3D printing ; injection molding ; personal protection ; rapid prototyping ; protective face shields ; mechatronics line ; visual servoing system ; wheeled mobile robot ; industrial robotic manipulator ; Industry 4.0 ; NDT ; magnetic particle inspection ; optimization ; condition monitoring ; vibration ; acoustic emission ; drive train ; data fusion ; machine learning ; product morphology ; core data model ; phase rule filter ; phase private data model ; storage system ; forklift AGV ; deep learning ; semantic segmentation ; H-Swish ; community transformation ; community innovation governance ; ternary space ; coupling and coordination analysis ; lean manufacturing ; lean principles ; pull principle ; production control mechanisms ; production processes ; lean implementation ; batch process ; partial least squares ; multi-phase ; multi-mode ; master production scheduling ; make-to-order ; mathematical programming ; agent-based ; overtime ; earliness ; tardiness ; equipment selection decision ; business compass ; energy consumption ; processing time ; beetle antennae search algorithm ; sustainable blank dimension design ; energy-saving ; low-carbon ; grey wolf algorithm ; gas–solid ; cyclone ; separator ; gas dynamics ; erosion ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general ; bic Book Industry Communication::P Mathematics & science::PN Chemistry
    Language: English
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  • 98
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-05-11
    Description: It was recently reported that pollution was responsible for 9 million premature deaths in 2015, making it the world's largest environmental risk factor for disease and premature death. Human and industrial activities generate various forms of residual wastes and by-products in a solid, liquid, or gaseous state. Waste generation starts with simple processes such as living, eating, and breathing. Managing waste and minimizing associated environmental impacts have become more challenging as worldwide populations and economies continue to grow. Once these hazardous chemicals are present in the environment, people can become exposed to them. Human health can be influenced by many factors, including exposure to physical, chemical, biological, and radiological contaminants in the environment.This reprint comprises research papers related to the aspects of environmental exposure to multiple toxic chemicals and human health. The manuscripts are focused on toxicology, biomonitoring, exposure and risk assessment, and endocrine disruptors.
    Keywords: pesticide ; insecticide ; herbicide ; fungicide ; rheumatoid arthritis ; autoimmune disease ; n/a ; ovary ; endocrine disruptors ; follicular growth ; hormonal secretions ; gene expression ; bisphenols ; plasticiser ; ewe ; tetracyclines ; sulfonamides ; quinolones ; streptomycines ; meat ; antibiotics ; risk assessment ; air pollution ; endothelium ; inflammation ; cardiovascular disease ; ALS ; Alzheimer’s ; Aβ1–42 ; α synuclein ; children ; cerebrospinal fluid ; cisternal CSF ; fronto-temporal dementia ; Metropolitan Mexico City ; nanoparticles ; olfactory bulb granule cells ; PM2.5 ; Parkinson’s ; hyperphosphorylated tau ; TDP-43 ; cadmium ; crab ; crustaceans ; heavy metal toxicity ; nutrition ; pollution ; biomagnification ; biomonitoring ; benchmark dose ; BMDL ; BMDU ; creatinine clearance ; chronic kidney disease ; eGFR ; NOAEL ; urine cadmium ; plant protection products ; residential exposure ; agriculture ; Africa ; exposure pathway ; intake dose ; temporal variations ; spatial variations ; pollutants ; women exposure ; microRNAs ; PAHs ; paint production plant ; volatile organic compounds (VOCs) ; inhalation exposure ; cancer risk ; non-cancer risk ; economic loss ; subway PM exposure ; health burden ; long-term mortality ; morbidity ; 3-PBA ; pyrethroid pesticides ; pregnancy ; newborn ; anthropometry ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
    Language: English
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  • 99
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-02-20
    Description: This Special Issue is intended to lay the foundation of AI applications focusing on oral health, including general dentistry, periodontology, implantology, oral surgery, oral radiology, orthodontics, and prosthodontics, among others.
    Keywords: machine learning ; artificial intelligence ; malocclusion ; diagnostic imaging ; active learning ; maxillary sinusitis ; convolutional neural network ; deep learning ; segmentation ; oral microbiota ; LEfSe ; PCoA ; alloprevotella ; prevotella ; core microbiota ; artificial neural networks ; oral cancer diagnosis ; oral cancer prediction ; pit and fissure sealants ; caries assessment ; visual examination ; clinical evaluation ; convolutional neural networks ; transfer learning ; deep learning network ; YOLOv4 ; mandibular third molar ; inferior alveolar nerve ; contact relationship ; panoramic radiograph ; deep learning methods ; caries diagnosis ; dental panoramic images ; radiography ; Fourier transform infrared spectroscopy ; FTIR imaging ; spectral biomarker ; multivariate analysis ; discriminant model ; oral squamous cell carcinoma ; oral epithelial dysplasia ; oral potentially malignant disorder ; risk stratification ; early oral cancer detection ; dentigerous cysts ; histopathology images ; image classification ; odontogenic keratocysts ; radicular cysts ; AI ; screening ; diagnosis ; dentistry ; ultrasonography ; tongue ; algorithm ; dysphagia ; impacted ; tooth ; detection ; neural networks ; proximal caries ; training strategy ; small dataset ; periapical radiograph ; X-ray ; tooth extraction ; oroantral fistula ; operative planning ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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  • 100
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-04-05
    Description: This reprint focuses on novel findings of diagnostic dermatopathology, such as diagnosable new morphological (histopathologic) findings, immunohistochemical and immunofluorescent markers, and molecular techniques. Dermatopathology is the most sophisticated area in anatomic pathology; we can easily observe superficial skin lesions using our eyes without the need for an invasive approach and can easily compare gross configurations to microscopic and immunohistochemical findings. Meanwhile, dermatopathology has recently focused on the study of various cutaneous diseases at the molecular biology level. Many cutaneous diseases are now being well-researched, and special attention is paid to keratoacanthoma, lichen sclerosus (et atrophicus), mycosis fungoides, atopic dermatitis, epidermolysis bullosa, extramammary Paget’s disease, malignant melanoma, psoriasis, and secondary neoplasms associated with nevus sebaceous.
    Keywords: extramammary Paget’s disease ; dermcidin ; prognosis ; lymph node metastasis ; survival ; mechanical intermittent compression ; malignant melanoma ; in vitro model ; cancer progression ; mycosis fungoides ; early stage ; diagnostic algorithm ; T-cell receptor rearrangement ; tumor-specific marker ; microRNA ; keratoacanthoma ; squamous cell carcinoma (SCC) ; keratoacanthoma-like SCC ; keratoacanthoma with malignant transformation ; crateriform neoplasms ; crateriform verruca ; crateriform seborrheic keratosis ; crateriform Bowen disease ; crateriform SCC arising from actinic keratosis ; crater form of infundibular SCC ; psoriasis ; STAT3 ; cancer ; immunohistochemistry ; atopic dermatitis ; biologic agents ; neuroimmune interactions ; type 2 inflammation ; PSORS1C3 ; PSORS1C1/CDSN ; LOC105375015 ; rs1062470 ; rs887466 ; rs10484554 ; single-nucleotide polymorphism ; epidermolysis bullosa ; mutation ; heterogeneity ; nevus sebaceus ; malignant tumor ; basal cell carcinoma ; sebaceus carcinoma ; lichen sclerosus ; extracellular matrix protein 1 ; lipoid proteinosis ; basement membrane zone ; laminin-332 ; collagen IV ; collagen VII ; glycosaminoglycan ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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