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  • bic Book Industry Communication::M Medicine  (219)
  • bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology  (184)
  • Cell & Developmental Biology
  • Chemical Engineering
  • General Chemistry
  • Physics
  • T1-995
  • MDPI - Multidisciplinary Digital Publishing Institute  (408)
  • 2020-2024  (408)
  • 1970-1974
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  • 2022  (408)
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  • 2020-2024  (408)
  • 1970-1974
  • 1910-1914
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This book introduces novel results on mathematical modelling, parameter identification, and automatic control for a wide range of applications of mechanical, electric, and mechatronic systems, where undesirable oscillations or vibrations are manifested. The six chapters of the book written by experts from international scientific community cover a wide range of interesting research topics related to: algebraic identification of rotordynamic parameters in rotor-bearing system using finite element models; model predictive control for active automotive suspension systems by means of hydraulic actuators; model-free data-driven-based control for a Voltage Source Converter-based Static Synchronous Compensator to improve the dynamic power grid performance under transient scenarios; an exact elasto-dynamics theory for bending vibrations for a class of flexible structures; motion profile tracking control and vibrating disturbance suppression for quadrotor aerial vehicles using artificial neural networks and particle swarm optimization; and multiple adaptive controllers based on B-Spline artificial neural networks for regulation and attenuation of low frequency oscillations for large-scale power systems. The book is addressed for both academic and industrial researchers and practitioners, as well as for postgraduate and undergraduate engineering students and other experts in a wide variety of disciplines seeking to know more about the advances and trends in mathematical modelling, control and identification of engineering systems in which undesirable oscillations or vibrations could be presented during their operation.
    Keywords: B-spline neural networks ; adaptive power system control ; coordinated multiple controllers ; StatCom ; exact plate theory ; thick plate ; bending vibration ; partial differential operator theory ; gauge condition ; data-driven control ; reactive power compensation ; STATCOM ; voltage control ; voltage source converter ; quadrotor UAV ; artificial neural networks ; robust control ; Taylor series ; B-splines ; particle swarm optimization ; active suspension ; model predictive control ; linear parameter varying ; ellipsoidal set ; attraction sets ; quadratic stability ; algebraic identification ; rotor-bearing system ; finite element model ; rotordynamic coefficients ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
    Language: English
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  • 2
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Nondestructive testing and evaluation (NDT&E) is one of the most important techniques for determining the quality and safety of materials, components, devices, and structures. NDT&E technologies include ultrasonic testing (UT), magnetic particle testing (MT), magnetic flux leakage testing (MFLT), eddy current testing (ECT), radiation testing (RT), penetrant testing (PT), and visual testing (VT), and these are widely used throughout the modern industry. However, some NDT processes, such as those for cleaning specimens and removing paint, cause environmental pollution and must only be considered in limited environments (time, space, and sensor selection). Thus, NDT&E is classified as a typical 3D (dirty, dangerous, and difficult) job. In addition, NDT operators judge the presence of damage based on experience and subjective judgment, so in some cases, a flaw may not be detected during the test. Therefore, to obtain clearer test results, a means for the operator to determine flaws more easily should be provided. In addition, the test results should be organized systemically in order to identify the cause of the abnormality in the test specimen and to identify the progress of the damage quantitatively.
    Keywords: composites ; multi-scale ; embedded damage ; non-destructive testing ; photoacoustic ; ultrasonic representation ; terahertz ; coded-aperture imaging ; convolution neural network (CNN) ; fast image reconstruction ; nondestructive evaluation ; acoustic nonlinearity parameter ; indirect method ; laser ultrasound ; fully non-contact ; surface acoustic wave ; UWB-PPM ; UWB-OOK ; buried objects ; nondestructive environment ; Levenberg–Marquardt method ; textured surface anomaly detection ; computer vision ; deep learning ; attention mechanism ; adaptive fusion ; power quality disturbances ; long short term memory ; convolutional neural network ; short time Fourier transform ; leaky Lamb wave ; semi-analytical finite element (SAFE) ; waveguide sensor ; finite-width plate ; waveguide plate ; width modes ; spatial beating ; Rayleigh–Sommerfeld integral (RSI) ; weld cracks ; eddy current nondestructive testing ; gradiently relative magnetic permeability ; heat affected zone ; austenitic stainless steel ; circulating fluidized bed combustion boiler ; water-cooled wall tube ; magnetic sensor array ; magnetic flux density ; flexible ultrasonic probe ; neutron irradiation embrittlement ; reactor pressure vessel ; magnetic nondestructive evaluation ; micromagnetic multiparameter microstructure and stress analysis 3MA ; magnetic adaptive testing ; 3D imaging of metal grains ; non-destructive testing methods ; stacking images ; SA106 carbon steel ; terahertz waves ; refractive index ; thickness measurement ; Shim stock films ; composite materials ; reflection mode ; neutron radiography ; Bragg-edge imaging ; gas tungsten arc welding (GTAW) ; low transformation temperature (LTT) steel ; austenite-to-martensite transformation ; Debye–Waller factor ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: This book captures advancements in the applications of computational intelligence (artificial intelligence, machine learning, etc.) to problems in the mineral and mining industries. The papers present the state of the art in four broad categories: mine operations, mine planning, mine safety, and advances in the sciences, primarily in image processing applications. Authors in the book include both researchers and industry practitioners.
    Keywords: truck dispatching ; mining equipment uncertainties ; orebody uncertainty ; discrete event simulation ; Q-learning ; grinding circuits ; minerals processing ; random forest ; decision trees ; machine learning ; knowledge discovery ; variable importance ; mineral prospectivity mapping ; random forest algorithm ; epithermal gold ; unstructured data ; blast impact ; empirical model ; mining ; fragmentation ; mine worker fatigue ; random forest model ; health and safety management ; stockpiles ; operational data ; mine-to-mill ; geostatistics ; ore control ; mine optimization ; digital twin ; modes of operation ; geological uncertainty ; multivariate statistics ; partial least squares regression ; oil sands ; bitumen extraction ; bitumen processability ; mine safety and health ; accidents ; narratives ; natural language processing ; random forest classification ; hyperspectral imaging ; multispectral imaging ; dimensionality reduction ; neighbourhood component analysis ; artificial intelligence ; mining exploitation ; masonry buildings ; damage risk analysis ; Bayesian network ; Naive Bayes ; Bayesian Network Structure Learning (BNSL) ; rock type ; mining geology ; bluetooth beacon ; classification and regression tree ; gaussian naïve bayes ; k-nearest neighbors ; support vector machine ; transport route ; transport time ; underground mine ; tactical geometallurgy ; data analytics in mining ; ball mill throughput ; measurement while drilling ; non-additivity ; coal ; petrographic analysis ; macerals ; image analysis ; semantic segmentation ; convolutional neural networks ; point cloud scaling ; fragmentation size analysis ; structure from motion ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-07-06
    Description: Connected intelligent sensing reshapes our society by empowering people with increasing new ways of mutual interactions. As integration technologies keep their scaling roadmap, the horizon of sensory applications is rapidly widening, thanks to myriad light-weight low-power or, in same cases even self-powered, smart devices with high-connectivity capabilities. CMOS integrated circuits technology is the best candidate to supply the required smartness and to pioneer these emerging sensory systems. As a result, new challenges are arising around the design of these integrated circuits and systems for sensory applications in terms of low-power edge computing, power management strategies, low-range wireless communications, integration with sensing devices. In this Special Issue recent advances in application-specific integrated circuits (ASIC) and systems for smart sensory applications in the following five emerging topics: (I) dedicated short-range communications transceivers; (II) digital smart sensors, (III) implantable neural interfaces, (IV) Power Management Strategies in wireless sensor nodes and (V) neuromorphic hardware.
    Keywords: wake-up receiver ; digital controller ; reliability ; electronic toll collection (ETC) system ; dedicated short range communication (DSRC) ; temperature compensation ; piezoresistive ; pressure sensor ; negative temperature coefficient ; ACE-Q100 ; CMOS ; epilepsy ; seizure ; multichannel neural recording ; feature extraction ; closed-loop neurostimulator ; low-power ; low-noise amplifier ; implantable medical device ; switched capacitor ; voltage converter ; wide load range ; multiphase operation ; variable frequency ; integrated circuits ; EEPROM reprogrammable fuses ; memory cells ; trimming techniques with fuses ; digital temperature sensor ; temperature sensor with digital serial interface ; asynchronous control logic ; successive approximation register (SAR) ; wireless access in vehicular environments (WAVE) ; low power consumption ; capacitive digital to analog converter (CDAC) ; CMOS neural amplifier ; AC coupling ; pseudoresistor ; nonlinear distortion ; area-efficient design ; sensor node ; power mode ; wireless sensor networks ; power management ; spiking neural network ; leaky integrate and fire ; neuromorphic ; artificial neural networks ; artificial intelligence ; image classification ; capacitance-to-digital converter ; iterative-delay-chain discharge ; CMOS capacitive sensor interface ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Today, the flow of electricity is bidirectional, and not all electricity is centrally produced in large power plants. With the growing emergence of prosumers and microgrids, the amount of electricity produced by sources other than large, traditional power plants is ever-increasing. These alternative sources include photovoltaic (PV), wind turbine (WT), geothermal, and biomass renewable generation plants. Some renewable energy resources (solar PV and wind turbine generation) are highly dependent on natural processes and parameters (wind speed, wind direction, temperature, solar irradiation, humidity, etc.). Thus, the outputs are so stochastic in nature. New data-science-inspired real-time solutions are needed in order to co-develop digital twins of large intermittent renewable plants whose services can be globally delivered.
    Keywords: self-healing grid ; machine-learning ; feature extraction ; event detection ; optimization techniques ; manta ray foraging optimization algorithm ; multi-objective function ; radial networks ; optimal power flow ; automatic P2P energy trading ; Markov decision process ; deep reinforcement learning ; deep Q-network ; long short-term delayed reward ; inter-area oscillations ; modal analysis ; reduced order modeling ; dynamic mode decomposition ; machine learning ; artificial neural networks ; steady-state security assessment ; situation awareness ; cellular computational networks ; load flow prediction ; contingency ; fuzzy system ; change detection ; data analytics ; data mining ; filtering ; optimization ; power quality ; signal processing ; total variation smoothing ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: The second volume of the book contains the manuscripts that were accepted for publication in the MDPI Special Topic "Cyber Security and Critical Infrastructure" after a rigorous peer-review process. Authors from academia, government and industry contributed their innovative solutions, consistent with the interdisciplinary nature of cybersecurity. The book contains 16 articles, including an editorial that explains the current challenges, innovative solutions and real-world experiences that include critical infrastructure and 15 original papers that present state-of-the-art innovative solutions to attacks on critical systems.
    Keywords: Cybersecurity ; critical Infrastructures ; privacy preservation ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: The recent successes of machine learning, especially regarding systems based on deep neural networks, have encouraged further research activities and raised a new set of challenges in understanding and designing complex machine learning algorithms. New applications require learning algorithms to be distributed, have transferable learning results, use computation resources efficiently, convergence quickly on online settings, have performance guarantees, satisfy fairness or privacy constraints, incorporate domain knowledge on model structures, etc. A new wave of developments in statistical learning theory and information theory has set out to address these challenges. This Special Issue, "Machine Learning and Information Theory", aims to collect recent results in this direction reflecting a diverse spectrum of visions and efforts to extend conventional theories and develop analysis tools for these complex machine learning systems.
    Keywords: supervised classification ; independent and non-identically distributed features ; analytical error probability ; empirical risk ; generalization error ; K-means clustering ; model compression ; population risk ; rate distortion theory ; vector quantization ; overfitting ; information criteria ; entropy ; model-based clustering ; merging mixture components ; component overlap ; interpretability ; time series prediction ; finite state machines ; hidden Markov models ; recurrent neural networks ; reservoir computers ; long short-term memory ; deep neural network ; information theory ; local information geometry ; feature extraction ; spiking neural network ; meta-learning ; information theoretic learning ; minimum error entropy ; artificial general intelligence ; closed-loop transcription ; linear discriminative representation ; rate reduction ; minimax game ; fairness ; HGR maximal correlation ; independence criterion ; separation criterion ; pattern dictionary ; atypicality ; Lempel–Ziv algorithm ; lossless compression ; anomaly detection ; information-theoretic bounds ; distribution and federated learning ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 9
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: Information is key, which means that measurements are key. For this reason, this book provides unique insight into state-of-the-art research works regarding optical measurement systems. Optical systems are fast and precise, and the ongoing challenge is to enable optical principles for in-process measurements. Presented within this book is a selection of promising optical measurement approaches for real-world applications.
    Keywords: speckle photography ; in-process measurement ; deep rolling process ; generalized phase shifting interferometry ; dual-aperture common-path interferometer ; real-time optical instrumentation ; optomechatronic systems ; electrical steel ; optical coherence tomography ; OCT ; scanning ; process monitoring ; laser material processing ; spot compensation ; low coherence interferometry ; LCI ; wind lidar ; Doppler lidar ; bistatic ; metrology ; traceability ; wind energy ; meteorology ; diffraction grating ; grating pitch ; mode-locked femtosecond laser ; laser diffraction ; diffraction equation ; measurement uncertainty analysis ; image processing ; pattern recognition ; wind energy turbines ; turbulence wedges ; coherence scanning interferometry ; in-process application ; Mirau interferometer ; vibration compensation ; interferometric distance sensor ; optical path length modulation ; oscillating reference mirror ; hairpin ; laser welding ; semantic segmentation ; dilated convolution ; sdu-net ; spatter detection ; quality assurance ; fast prediction time ; in situ measurement ; optical metrology ; quality control ; interferometry ; fringe projection ; computational shear interferometry ; coherence function ; structure function ; additive manufacturing ; medium voltage switchgear ; SF6 alternatives ; UV-Vis spectroscopy ; gas mixing modeling ; multicomponent diffusion analysis ; explosion ; coal dust ; methane ; explosion suppression ; spectral characteristics ; explosion pressure ; radiation intensity ; free radicals ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: With the announcement of the European Green Deal, which defines a set of policy initiatives aimed at achieving a 50–55% reduction in carbon emissions by 2030 and making Europe climate neutral in 2050, the challenge of energy transition becomes even more critical. The transformation of national energy systems towards sustainability is progressing throughout all Central and Eastern European (CEE) countries, yet the goals and results are different. Most EU Member States have made substantial progress towards meeting their long-term commitments of emissions reductions. However, some bloc members have struggled to meet their obligations. An effective energy transition requires the introduction of appropriately designed policy instruments and of robust economic analyses that ensure the best possible outcomes at the lowest costs for society. In this context, this Special Issue aims to bring into the discussion the challenges that CEE countries have to face and overcome while undergoing energy transition.
    Keywords: climate change ; food security ; grand challenges ; multiple factor analysis ; regional studies ; renewable energy ; sustainable development goals ; support systems ; energy policy ; cogeneration ; capacity market ; individual cogeneration premium ; trade globalization ; financial globalization ; CO2 emissions ; real GDP per capita ; bootstrap panel Granger causality ; EU transition economies ; photovoltaics ; renewable energy sources ; “My Electricity” ; renewable energy policy ; Poland ; “Mój Prąd” ; grant ; renewable energy grants ; renewable energy support ; economic appraisal ; social discount rate ; Ramsey formula ; consumption rate of interest ; social opportunity cost ; renewable energy sources (RES) ; green energy transformation ; sustainable development ; energy cooperatives ; coopetition ; Renewable Energy Communities ; management ; households ; energy consumption ; platform ; EU ETS ; CO2 ; emissions trading ; energy companies from Central and Eastern Europe ; decarbonisation ; energy transition ; low-carbon technology ; climate and energy policy ; indicators ; biomass ; electric vehicle ; electromobility ; energy balance ; efficiency engines ; clustering ; charging stations ; data analysis ; hydrogen cells ; energy law ; customer preferences ; electric car ; PHEV ; driving technique ; limestone sorbents ; flue gas desulphurisation ; FGD gypsum ; coal-fired power plants ; climate policy ; capacity adequacy ; linear programming ; COVID-19 pandemic ; lockdown ; electricity demand profiles ; Polish energy mix ; energy transition in Poland ; social acceptance ; carbon emissions ; fleet electrification ; sustainable mobility ; fleet management ; energy mix ; onshore wind ; risk assessment ; cash-flows ; discount rate ; cost of capital ; cost of equity ; district heating ; decarbonization ; energy efficiency ; Hubgrade ; remuneration mechanism ; power generation ; new investments ; combined heat and power ; optimization ; thermal energy storage ; uncertainty ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: Animal production (e.g., milk, meat, and eggs) provides valuable protein production for human beings and animals. However, animal production is facing several challenges worldwide such as environmental impacts and animal welfare/health concerns. In animal farming operations, accurate and efficient monitoring of animal information and behavior can help analyze the health and welfare status of animals and identify sick or abnormal individuals at an early stage to reduce economic losses and protect animal welfare. In recent years, there has been growing interest in animal welfare. At present, sensors, big data, machine learning, and artificial intelligence are used to improve management efficiency, reduce production costs, and enhance animal welfare. Although these technologies still have challenges and limitations, the application and exploration of these technologies in animal farms will greatly promote the intelligent management of farms. Therefore, this Special Issue will collect original papers with novel contributions based on technologies such as sensors, big data, machine learning, and artificial intelligence to study animal behavior monitoring and recognition, environmental monitoring, health evaluation, etc., to promote intelligent and accurate animal farm management.
    Keywords: pig weight ; body size ; estimation ; deep learning ; convolutional neural network ; pig identification ; mask scoring R-CNN ; soft-NMS ; group-housed pigs ; audio ; dairy cow ; mastication ; jaw movement ; forage management ; precision livestock management ; equine behavior ; wearable sensor ; intermodality interaction ; class-balanced focal loss ; absorbing Markov chain ; cow behavior analysis ; prediction of calving time ; cow identification ; EfficientDet ; YOLACT++ ; cascaded model ; instance segmentation ; generative adversarial network ; machine learning ; automated medical image processing ; deep neural network ; animal science ; CT scans ; computer vision ; cow ; extensive livestock ; sensorized wearable device ; monitoring ; parturition prediction ; radar sensors ; radar signal processing ; animal farming ; computational ethology ; signal classification ; wavelet analysis ; dairy welfare ; hierarchical clustering ; mutual information ; precision livestock farming ; time budgets ; unsupervised machine learning ; wearables design ; animal-centered design ; animal telemetry ; modularity ; smart collar ; design contributions ; additive manufacturing ; low-frequency tracking ; commercial aviary ; laying hens ; false registrations ; tree-based classifier ; animal behaviour ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: This book focuses on the modelling and the design process of gas bearings, on the experimental validation of such models, and on their applications. In particular, recent developments about foil bearings, aerostatic bearings, porous bearings, and non-contact precision positioning systems are shown.
    Keywords: aerostatic spindle ; fluid–structure interaction ; restrictor geometrical parameters ; structural dimension ; optimal design ; bump foil gas bearing ; thermo-hydrodynamic model ; temperature field ; thermal characteristics analysis ; foil bearing ; turbo machinery ; gas bearing ; industrial application ; air-bearing ; precision positioning ; tribotronics ; rotation accuracy ; roundness ; cylindricity ; dispersion coefficient ; gas bearings ; porous materials ; rotordynamics ; force coefficients ; aerostatic journal bearings ; porous bearing ; annular-thrust bearing ; numerical simulation ; finite element method ; dynamic coefficients ; eccentricity ; tilting ; tilting velocity ; partial arc ; PCB spindles ; dynamic identification ; logarithmic decrement method ; complex exponential method ; half-power method ; damping factor identification ; rigid rotor ; modal analysis ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This book presents 22 of the accepted presentations at the 1st International Electronic Conference on Algorithms which was held completely online from September 27 to October 10, 2021. It contains 16 proceeding papers as well as 6 extended abstracts. The works presented in the book cover a wide range of fields dealing with the development of algorithms. Many of contributions are related to machine learning, in particular deep learning. Another main focus among the contributions is on problems dealing with graphs and networks, e.g., in connection with evacuation planning problems.
    Keywords: bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: One of the great challenges of contemporary society is establishing a sustainable way of life in harmony with the environment without compromising economic growth and technological development. On the other hand, the increase in the world population has driven per capita consumption, and consequently, the generation of waste. Because of this, new materials are being developed from different types of waste. This Special Issue aims to highlight and share recent scientific findings in the area of “New Environmentally Friendly and Sustainable Materials” manufactured from different material types (polymers, ceramics, metallics, and composites) and urban, industrial, mining and agricultural wastes. Moreover, scientific topics such as improving performance and durability, materials characterization, hybrid materials, foams and porous materials, trends and advances, and mechanical, electrical, magnetic, optical, and thermal properties will also be accepted.
    Keywords: palygorskite ; adsorption ; anionic dye ; cationic dye ; water treatment ; perlite tailings ; aggregate ; alkali–silicate reaction ; ceramic residue ; alkaline activation ; experimental design ; durability tests ; kaolin ; solid residues ; pozzolanic activity ; cement mortar ; carbonation ; poly (lactic acid) ; high-density biopolyethylene ; bioblends ; compatibilization ; scheelite tailings ; sustainable ceramic mass ; red ceramic ; firing parameters ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: According to the National Research Council, the use of embedded systems throughout society could well overtake previous milestones in the information revolution. Mechatronics is the synergistic combination of electronic, mechanical engineering, controls, software and systems engineering in the design of processes and products. Mechatronic systems put “intelligence” into physical systems. Embedded sensors/actuators/processors are integral parts of mechatronic systems. The implementation of mechatronic systems is consistently on the rise. However, manufacturers are working hard to reduce the implementation cost of these systems while trying avoid compromising product quality. One way of addressing these conflicting objectives is through new automatic control methods, virtual sensing/estimation, and new innovative hardware topologies.
    Keywords: independent-wheel drive ; steering assistance ; nonlinear system ; active disturbance rejection control ; smooth road feeling ; city bus transport ; electric vehicles ; electrification ; software tool ; planning ; control ; charging management ; simulation ; analysis ; energy management ; hybrid electric vehicle ; powertrain electrification ; equivalent consumption minimization ; supercharging ; hardware-in-the-loop experiments ; driving force distribution ; decentralized traction system ; 4WD electric vehicle ; energy efficiency ; traction control ; efficiency optimization ; air mobility ; fuel cell hybrid aircraft ; stochastic optimal control ; drift counteraction optimal control ; normal force estimation ; unbiased minimum variance estimation ; controller output observer ; youla parameterization ; adaptive cruise control ; automated driving ; energy-saving ; fuel-saving ; optimal control ; passenger comfort ; new energy vehicles ; speed prediction ; macroscopic traffic model ; traffic big-data ; deep learning ; vehicle lateral dynamic and control ; unresolved issues ; application of speed prediction ; electric vehicle ; hybrid vehicle ; lithium ion ; ultracapacitor ; battery aging ; EHB ; EMB ; EWB ; system modeling ; bond graph ; optimization ; control design ; Youla parameterization ; robust control ; nonlinear optimization ; brake-by-wire ; actuator ; electro-mechanical brake ; electronic wedge brake ; electro-hydraulic brake ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-24
    Description: This reprint contains contributions focusing on recent developments in the design, synthesis, and characterization of nanocatalysts intended for applications in environmental protection and low carbon footprint power generation processes thanks to the overall effort of scientists and researchers for a cleaner and more sustainable future. New synthetic approaches to the production and in-depth characterization of innovative nanostructured composites and hybrid materials with well-controlled textural and surface chemistry properties that give performance advantages in a variety of important environmental and energy applications such as CO2 utilization/recycling, hydrogen and syngas production, biosensing, and biocatalysis as well as in ways to obtain useful materials from waste are included, among others. This reprint is the result of one of the cutting-edge Special Issues in the field of Nanoscience and Nanotechnology organized by Nanomaterials to celebrate its 10th anniversary.
    Keywords: nanocarbon ; rocket fuels ; furfuryl alcohol ; fuming nitric acid ; waste ; hypergolics ; carbon materials ; CO2 methanation ; bimetallic catalysts ; Ni-based catalysts ; promoters ; alloy nanoparticles ; bimetallic synergy ; hybrid nanoflowers ; biosynthesis ; influencing factors ; biosensing cues ; bio-catalysis ; propane ; steam reforming ; hydrogen production ; perovskite ; ruthenium ; rhodium ; La2O2CO3 ; stability ; propane steam reforming ; H2 production ; Ni ; TiO2 ; CeO2 ; YSZ ; ZrO2 ; Al2O3 ; drifts ; n/a ; HDO reaction ; transition metal phosphides ; structure ; acidity ; characterization ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these pathologies.
    Keywords: chronic intestinal pseudo-obstruction ; parenteral nutrition ; pediatrics ; myopathy ; neuropathy ; IBS ; microbiota ; visceral hypersensitivity ; colorectal motility ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; postoperative complications ; surgery ; preoperative therapy ; biologic therapy ; bio-naïve ; IBD ; pro-inflammatory cytokines ; lymphocyte migration ; treatment ; inflammatory bowel diseases ; biologic treatment ; combination ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).
    Keywords: neurorehabilitation ; cognitive enhancement in children ; tech mediated rehabilitation ; developmental coordination disorders ; virtual reality ; telerehabilitation ; specific learning disorders ; cerebral palsy ; well-being ; dyslexia ; rhythm ; music therapy ; intervention ; developmental dyslexia ; new technologies ; augmented reality ; good practices ; Delphi method ; rehabilitation ; remote intervention ; children ; age ; severity ; improvement ; follow-up ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Cement and lime currently are the most common binders in building materials. However, alternative materials and methods are needed to overcome the functional limitations and environmental footprint of conventional products. This Special Issue dedicated to “New frontiers in cementitious and lime-based materials and composites” gathers selected reviews and experimental articles that showcase the most recent trends in this multidisciplinary field. Authoritative contributions from all around the world provide important insights into all areas of research related to cementitious and lime-based materials and composites, spanning from structural engineering to geotechnics, including materials science and processing technology. This Topical Collection is intended to foster innovation and help researchers and developers to identify new solutions for a more sustainable and functional built environment.
    Keywords: durability ; hardened properties ; green composite ; fresh properties ; recycled concrete aggregates ; natural coarse aggregates ; enzyme-induced calcite precipitation ; microbial-induced calcite precipitation ; geotechnical engineering ; geoenvironmental engineering ; precast concrete wall ; interfacial bonding strength ; joint concrete ; interface processing ; washed rough surface ; roughness ; storage time ; cement mortar ; End-of-Life Tyre ; waste ; surface treatment ; compressive strength ; flexural strength ; workability ; fly ash ; freezing shaft sinking ; shaft lining structure ; uneven pressure ; hybrid fiber-reinforced concrete ; crack ; autogenous self-healing ; curing conditions ; supplementary cementitious materials (SCMs) ; GRC-PC ; integrated wall panels ; composite method ; shrinkage properties ; dissipation energy density ; high-strength concrete ; Weibull distribution ; damage mechanics ; constitutive model ; repeated impact ; ACI 544-2R ; high temperatures ; fire ; residual strength ; lime-cement mortar ; air-entrained agent ; heritage conservation ; reconstruction and restoration of historical buildings ; properties ; mechanical ; electrical resistivity ; ecofriendly ternary concrete ; SCBA ; SF ; coastal cemented soil ; nano silica ; iron tailings ; mechanical properties ; microscopic mechanism ; granite dust ; stabilizer ; particle size ; plasticity ; unconfined compression strength ; cement ; lime ; sustainable materials ; fibre-reinforced composite ; recycled aggregates ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Exceptional loads on buildings and structures are known to take origin and manifest from different causes, like natural hazards and possible high-strain dynamic effects, human-made attacks and impact issues for load-bearing components, possible accidents, and even unfavorable/extreme operational conditions. All these aspects can be critical for specific structural typologies and/or materials that are particularly sensitive to external conditions. In this regard, dedicated analysis methods and performance indicators are required for the design and maintenance under the expected lifetime. Typical issues and challenges can find huge efforts and clarification in research studies, which are able to address with experiments and/or numerical analyses the expected performance and capacity of a given structural system, with respect to demands. Accordingly, especially for existing structures or strategic buildings, the need for retrofit or mitigation of adverse effects suggests the definition of optimal and safe use of innovative materials, techniques, and procedures. This Special Issue follows the first successful edition and confirms the need of continuous research efforts in support of building design under extreme loads, with a list of original research papers focused on various key aspects of structural performance assessment for buildings and systems under exceptional design actions and operational conditions.
    Keywords: blast loads ; slab-column joints ; prediction model ; damage level ; progressive collapse ; steel beam-to-column connections ; catenary mechanism ; double-span assemblies ; stiffness degradation ; timber-to-timber composite (TCC) joints ; push-out (PO) test setup ; inclined self-tapping screws (STSs) ; finite-element (FE) method ; cohesive zone modelling (CZM) method ; boundaries ; friction ; sensitivity study ; prototype abutment ; non-destructive test ; surcharge load ; mode number ; scour ; steel truss ; roof structure ; partial collapse ; finite element analysis ; lightning strike ; cable-stayed bridge ; social disaster ; blast scenario ; blast analysis ; LS-DYNA ; balau wood ; cross-arm ; transmission tower ; bracing system ; creep ; findley’s power law model ; burger model ; top-seat angle connections (TSACW) ; component-based models ; initial stiffness ; ultimate moment capacity ; moment-rotation relation ; artificial neural network (ANN) ; sensitivity analysis (SA) ; reinforced concrete column ; multi-column pier ; seismic behavior ; lap-splice ; transverse reinforcement ; plastic hinge ; ductility ; bonded-in rod (BiR) connections ; adhesives ; fracture modes ; moisture ; experiments ; linear elastic fracture mechanics (LEFM) ; analytical model ; aeroelastic experiments ; experimental uncertainty ; singular value decomposition ; correlation field ; cathedral ; foundation rehabilitation ; jacked-in piles ; soil injection ; cracks ; masonry ; differential equation of motion ; Legendre–Galerkin matrix (LGM) method ; algebraic polynomials ; single degree of freedom (SDOF) ; multi degree of freedom (MDOF) ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: Electrical machines are one of the most important components of the industrial world. They are at the heart of the new industrial revolution, brought forth by the development of electromobility and renewable energy systems. Electric motors must meet the most stringent requirements of reliability, availability, and high efficiency in order, among other things, to match the useful lifetime of power electronics in complex system applications and compete in the market under ever-increasing pressure to deliver the highest performance criteria. Today, thanks to the application of highly efficient numerical algorithms running on high-performance computers, it is possible to design electric machines and very complex drive systems faster and at a lower cost. At the same time, progress in the field of material science and technology enables the development of increasingly complex motor designs and topologies. The purpose of this Special Issue is to contribute to this development of electric machines. The publication of this collection of scientific articles, dedicated to the topic of electric machine design and application, contributes to the dissemination of the above information among professionals dealing with electrical machines.
    Keywords: electric AWD tractor ; SOC level ; simulation model ; load measurement system ; driving test ; brushless direct current motor with permanent magnet (BLDCM) ; winding configurations ; star ; delta ; star–delta ; fault states ; open circuit (OC) ; FFT ; neutral-point voltage ; electrical machine ; hydro generator ; faulty synchronization ; finite element method ; field-circuit modeling ; permanent magnet machines ; hybrid excitation ; electric vehicles ; wind power generator ; finite element methods ; variable speed machines ; synchronous generator ; permanent magnets ; demagnetization ; motor control ; switched reluctance motor ; MATLAB ; simulation ; wheel hub motor ; electric drive ; permanent magnet synchronous motor ; electrical machines ; thermal modeling ; preformed coils ; insulation systems ; pre-shaped conductor ; system model ; structural dynamics ; multibody simulation ; transient electrical machine model ; permanent magnet synchronous machine ; induction machine ; dynamic gear forces ; planetary gear ; synchronous condenser ; different materials ; magnetic flux leakage in the end ; eddy current loss ; fluid–solid coupling ; finite element analysis (FEA) ; interior PM synchronous motor ; surface PM synchronous motor ; traction applications ; finite element analysis ; flux switching machine ; flux bridge ; magnetic flux leakage ; variable flux machine ; axial flux generator ; spatial harmonic interaction ; harmonic balance method ; turbo-generator ; eddy current losses ; data driven ; support vector regression ; multi-layer perceptron ; vane pump ; electric motor ; integrated motor-pump assembly (IMPA) ; balanced vane pump ; fluid power drives ; brushless DC electric motor ; permanent magnet machine ; measurements ; high-speed motor ; electromagnetic analysis ; mechanical analysis ; thermal analysis ; electromechanical convertor ; drive system component ; electromagnetic calculation ; MR fluids ; MR multi-disc clutch ; clutch design ; electric train ; hybrid excited linear flux switching machine ; rope-less elevator ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This Special Issue was intended to contribute to the sustainable mobility agenda through enhanced scientific and multi-disciplinary knowledge to investigate concerns and real possibilities in the achievement of a greener mobility and to support the debate between industry and academic researchers, providing an interesting overview on new needs and investigation topics required for future developments.
    Keywords: digging trajectory ; cable shovel ; robotic excavation ; multi-objective genetic algorithm ; electric vehicle ; propulsion cooling system ; modularity ; thermal management ; control optimization ; driving cycle ; energy consumption ; Markov chains ; driving range ; electrification ; green mobility ; compact off-highway vehicles ; battery electric ; urban air mobility ; WTW emissions ; hybrid electric vehicles ; battery aging ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: The concept of advanced therapy medicinal products (ATMPs) encompasses novel kinds of medicines for human use that are based on genes, cells or tissues. These intend to offer not only regeneration, but complete functional recovery of diseased tissues and organs using different strategies. Gene therapy, cell therapy and tissue engineering are the main areas in which promising advanced therapies are emerging. The eye is a very complex organ whose main structures, the cornea and the retina, play a pivotal role in maintaining normal vision, as severe alterations in these tissues can lead to blindness. Ocular tissues are starting to benefit from ATMPs by fighting against the enormous complexity and devastating potential of many ocular diseases. However, developments arising from this field of work face important challenges related to vectors to deliver drugs and genetic material to target tissues, suitable biomaterials to prepare cell scaffolds and cell stemness, among others—not to mention the complicated legislation around ATMPs, the complexity in production and quality control and the absence of standardized protocols.The purpose of this Special Issue is to serve as an overview of the current progress in the application of cell and gene therapies, as well as tissue engineering to restore functionality in diseased ocular structures, and the challenges linked to reaching patients.
    Keywords: MPC polymer ; dry eye ; ocular surface ; lacrimal fluid ; mucin ; 3D bioprinting ; cornea ; retina ; ophthalmology ; tissue regeneration ; electrospinning ; conjunctiva ; decellularized tissue matrix ; small intestinal submucosa ; urinary bladder matrix ; polycaprolactone ; fiber ; tissue engineering ; stratification ; conjunctival epithelial cells ; hydrogel ; keratoplasty ; scaffold ; collagen ; advanced therapy medicinal product ; ATMP ; cell therapy ; gene therapy ; eye ; ocular ; regulatory ; marketing authorization ; double-crosslinking ; carbodiimide ; glutaraldehyde ; sodium metabisulfite ; sodium borohydride ; EDC/NHS ; stem cells ; retinal diseases ; optic nerve diseases ; cell replacement ; cell sources ; advanced therapies ; ocular mucosa ; blindness ; CLET ; limbal niche ; limbal stem cell ; LSCD ; mesenchymal stem cell transplantation ; MSCT ; corneal limbus ; decellularized xenograft ; recellularization ; mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: Patient outcomes remain poor for many cancers despite improvements in treatments and new molecular-targeted biomedicines for certain cancer types or subtypes. Dose-limiting toxicity, a narrow therapeutic index, and the development of resistance to traditional anti-cancer agents are well-established. It is apparent that inherent and acquired drug resistance are major challenges with molecular-targeted agents and that on- as well as off-target side effects can still occur. Other issues include drug metabolism by the body and safely supplying a sufficient amount of active drug to the tumor cells. There is a clear and urgent need for new molecular targets and drugs that specifically target cancer cells in different ways to existing approved drugs. This book, through a collection of eight research articles and two review articles from the Biomedicines themed Special Issue ‘Novel Anti-Cancer Agents and Cellular Targets and Their Mechanism(s) of Action’, provides a snapshot of some of the diverse and exciting research approaches being taken by the cancer research community in trying to address some of these therapeutic challenges.
    Keywords: microtubule acetylation ; triple-negative breast cancer ; anti-cancer agent ; apoptosis ; K562 ; 8-hydroxydaidzein ; autophagy ; BCR-ABL ; MAPK ; NF-κB ; c-myc ; RNA interference ; siRNA ; oncogene ; gene silencing ; expression ; nanosystems ; Cytochrome P450 ; CYP1A1 ; CYP1B1 ; CYP2W1 ; breast cancer ; prodrug ; bioprecursor ; duocarmycin ; phortress ; AQ4N ; 5-FU resistance ; colorectal cancer ; drug repurposing ; Genomics of Drug Sensitivity in Cancer ; Connectivity Map ; anticancer drug ; B-lactam steroid alkylators ; synthetic lethality ; poly (ADP-ribose) polymerase inhibitors ; ovarian cancer ; hybrid steroidal alkylating agents ; migration ; invasion ; glioblastoma ; CCN1 ; mesenchymal–amoeboid transition ; biomarker ; HepG2 ; Huh7 ; isatin sulfonamides ; angiogenesis ; cancer hallmarks ; molecular docking ; EGFR tyrosine kinase inhibitor ; photon upconversion ; triplet-triplet annihilation ; in vivo imaging ; PLGA ; nanoparticles ; affibody molecule ; human epidermal growth factor receptor 3 (HER3) ; BxPC-3 ; emtansine ; DM1 ; albumin binding domain ; affibody drug conjugate (AffiDC) ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-08-12
    Description: The scope of the Special Issue is research and reviews on evaluations of current practice, innovations in medication management, developments in therapeutics, and pharmaceutical science research that informs and improves practice and administration, as well as the social and administrative pharmacy. We will mainly feature original research, reviews, short reports, and clinical studies, but also case reports, descriptive/how-to, and commentary submissions for consideration.
    Keywords: older adults ; polypharmacy ; internal medicine ward ; community pharmacy ; drug disposal ; unused medication ; environment ; awareness ; practice ; ambulatory care facilities ; health workforce ; pharmacists ; Taiwan ; Commonwealth Partnerships for Antimicrobial Stewardship (CwPAMS) ; National Health Service (NHS) ; Chief Pharmaceutical Officer’s Global Health Fellowship ; CPhOGH Fellows ; CwPAMS ; pharmacy ; fellowship ; health partnerships ; antimicrobial resistance (AMR) ; global health ; leadership ; non-prescription medicines ; emergency contraception ; community pharmacies ; information gathering ; availability ; pricing ; mystery calls ; ulipristal acetate ; levonorgestrel ; Germany ; e-prescription ; prescription writing ; Jazan ; Saudi Arabia ; prescription errors ; medicine consumption ; defined daily dose ; adolescents and young adults ; cancer patients ; fragility ; pain ; MUR ; medication review ; barriers ; pharmacist ; pregabalin ; abuse ; community pharmacists ; reproductive health ; contraception ; emergency contraceptives ; patient education ; biosensing technology ; digital medicine system ; medication adherence ; medication event monitoring system ; nonadherence ; prescription opioids ; mortality ; standardized mortality ratio ; underlying cause of death ; prescriptions ; community pharmacy services ; emergency prescribing ; pharmacy practice ; pharmacy law and regulation ; COVID-19 ; additional monitoring ; black triangle ; adverse event reporting ; pharmacovigilance ; intervention ; outcomes ; systematic review ; pharmacy education ; decision to study in pharmacy ; selecting pharmacy as a first choice ; pharmacogenomics ; learning activity ; asynchronous learning ; virtual learning ; student survey ; Program of All-Inclusive Care for the Elderly ; adverse drug events ; medication-related problems ; drug-related problems ; medication safety ; Medicare ; Medicaid ; financial management ; pharmacy management ; business ; entrepreneurship ; pharmacy students ; perception ; attitudes ; ability ; interprofessional ; simulation ; acute care ; nursing ; students ; standardized patients ; high fidelity ; SPICE-R2 ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: The trend of digitalization is an omnipresent phenomenon nowadays – in social life and in the dental community. Advancement in digital technology has fostered research into new dental materials for the use of these workflows, particularly in the field of prosthodontics and oral implantology.CAD/CAM-technology has been the game changer for the production of tooth-borne and implant-supported (monolithic) reconstructions: from optical scanning, to on-screen designing, and rapid prototyping using milling or 3D-printing. In this context, the continuous development and speedy progress in digital workflows and dental materials ensure new opportunities in dentistry.The objective of this Special Issue is to provide an update on the current knowledge with state-of-the-art theory and practical information on digital workflows to determine the uptake of technological innovations in dental materials science. In addition, emphasis is placed on identifying future research needs to manage the continuous increase in digitalization in combination with dental materials and to accomplish their clinical translation.This Special Issue welcomes all types of studies and reviews considering the perspectives of the various stakeholders with regard to digital dentistry and dental materials.
    Keywords: Dentistry ; Prosthodontics ; Implant ; dentistry ; Digital ; technology ; Dental ; materials ; Rapid ; prototyping ; CAD/CAM ; Optical ; scanning ; 3D ; printing ; Translational ; research ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Rare diseases, or orphan diseases, are those that individually affect a small number of patients, but taken together affect over 300 million people worldwide. They are characterized by their etiological, diagnostic and evolutionary complexity, important morbi-mortality, with high levels of disability that entail and hinder the development of a normal vital subject, not only in those who suffer from them, but also their families; therefore, a comprehensive social health approach is necessary to address this problem.About 80% of rare diseases have a genetic origin, mainly monogenic; thus, genetic testing is mandatory for the confirmation of clinical diagnostics and to ensure correct genetic counseling. Next-generation sequencing (NGS) has enabled a revolution in genetic diseases, specially in rare diseases. However, their complexity makes diagnoses difficult even with the advent of NGS.In this Special Issue, we present several examples of the complexity of genetic diagnosis for most of these diseases and the consequences that genetic testing implies for genetic counseling. There are examples of the genetic heterogeneity of hearing loss, some metabolic and lisosomal disorders, ataxia, Prader–Willi syndrome, and three comprehensive reviews on syndromic retinal dystrophies, the complexity of the molecular diagnosis of neuromuscular disorders, and the value of genetic counseling before and after a genetic test.
    Keywords: retina ; inherited retinal diseases ; syndrome ; Turner syndrome ; mosaicism ; ring chromosomes ; growth hormone deficiency ; pituitary microadenoma ; clinical genetics ; early onset ataxia ; dystonia ; neurodevelopment ; network analysis ; bioinformatics ; ataxia ; phenotype ; child ; NGS ; next generation sequencing ; inborn errors of metabolism ; lysosomal disorders ; neuromuscular disease ; genetic testing ; whole exome sequencing ; Prader–Willi syndrome ; imprinting disorder ; recombinant human growth hormone ; insulin-like growth factor 1 ; HMGLD ; HMGCL ; HMG-CoA lyase deficiency ; inherited metabolic diseases ; familial hearing loss ; multiple diagnoses ; non-syndromic hearing loss ; ACTG1 ; MYH9 ; genetic counselling ; rare diseases ; professional recognition ; hearing loss ; genetic diagnosis ; SLC26A4 ; DFNB4 ; Tuvinians ; Altaians ; Southern Siberia ; Russia ; GSDME ; DFNA5 ; single-exon CNV ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: Pumped storage technology is a large-scale, efficient, flexible and clean energy storage technology. The core of it is the design of pumped storage units, which involves the operation and flow characteristics of vane hydraulic machinery under pump and turbine modes, as well as the complex flow conditions of the upstream and downstream flow channels of the units. With this as the background, this book expounds on the relevant problems and their solutions, providing a scientific basis for the development of pumped storage technology. I hope this book can provide as a useful reference for readers.
    Keywords: tip clearance ; vertical axial flow pump ; whole channel numerical simulation ; pressure pulsation ; leakage vortex ; bulb tubular pump ; numerical simulation ; adjusting speed ; transition process ; pressure fluctuation ; pump turbine ; flow energy loss ; flow–head stability ; guide vane opening ; V-inclined pipe ; sand transport ; critical velocity ; flow pattern ; orthogonal test method ; lateral intake ; CFD numerical simulation ; diversion pier ; prefabricated pumping station ; centrifugal pump ; energy characteristics ; internal flow field ; test ; integrated pump gate ; inlet channel ; outlet channel ; hydraulic performance ; “S” shaped airfoil ; bidirectional axial flow pump ; axial flow pumps ; energy ; cavitation ; numerical calculation ; Francis turbine ; sediment erosion ; clearance ; CFD ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: The year 2021 saw the publication of the Special Issue “"Diseases of the Salivary Glands" (https://www.mdpi.com/journal/jcm/special_issues/Salivary_Glands), Part I, covering recent and novel advancements as well as future trends in the field of research evaluating diagnostic and therapeutic treatment of salivary gland (SGs) diseases. Given the enormous success of Part I, the Special Issue “Diseases of the Salivary Glands” Part II has been launched, with the firm belief that it will enrich the panorama of world research in this field. Topics include: 1) Clinical features and presentation of potentially malignant SG disorders; 2) Risk factors and etiopathogenesis of SGs tumors; 3) Etiopathogenesis and molecular mechanisms involved in the chronic inflammatory condition characterizing Sjӧgren’s syndrome; 4) New discoveries in the field of micro RNAs associated with Sjӧgren’s syndrome; 5) Molecular markers linked to development and progression of SG diseases: current knowledge and future implications; 6) More innovative techniques for the study of the SG diseases: current limitations and future directions.
    Keywords: xerostomia ; dry mouth ; protein–protein interaction ; drug target ; head and neck cancer ; Sjögren’s Syndrome ; major histocompatibility complex (MHC) ; human leukocyte antigen (HLA) ; autoantigens ; T cells ; E-cadherins ; salivary glands ; morphogenesis ; EMT ; Sjögren’s syndrome ; autoimmunity ; hydrogen peroxide ; adrenaline ; blood loss ; tonsillectomy ; fibrosis ; pleomorphic adenoma ; epithelial–mesenchymal transition ; carcinoma ex-pleomorphic adenoma ; 99mTc-interleukin-2 ; activated lymphocytes ; inflammation imaging ; Sjögren syndrome ; nuclear medicine ; radiopharmaceuticals ; PET ; SPECT ; Follistatin-like 1 protein ; TGF-β1 ; SMAD2/3 ; fluoride ; sodium fluoride ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: These proceedings contain research papers that were accepted for presentation at the 14th International Conference Inter-Eng 2020 ,Interdisciplinarity in Engineering, which was held on 8–9 October 2020, in Târgu Mureș, Romania. It is a leading international professional and scientific forum for engineers and scientists to present research works, contributions, and recent developments, as well as current practices in engineering, which is falling into a tradition of important scientific events occurring at Faculty of Engineering and Information Technology in the George Emil Palade University of Medicine, Pharmacy Science, and Technology of Târgu Mures, Romania. The Inter-Eng conference started from the observation that in the 21st century, the era of high technology, without new approaches in research, we cannot speak of a harmonious society. The theme of the conference, proposing a new approach related to Industry 4.0, was the development of a new generation of smart factories based on the manufacturing and assembly process digitalization, related to advanced manufacturing technology, lean manufacturing, sustainable manufacturing, additive manufacturing, and manufacturing tools and equipment. The conference slogan was “Europe’s future is digital: a broad vision of the Industry 4.0 concept beyond direct manufacturing in the company”.
    Keywords: T1-995 ; History of engineering & technology ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues
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  • 35
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-24
    Description: Endometriosis is defined as the presence of endometrial-like endometrial cells, glands, and stroma outside the uterus, causing a strong inflammatory-like microenvironment in the affected tissue. The exact prevalence of endometriosis is unknown, but estimates range from 2%–10% of women of reproductive age, to 50% of infertile women. Its etiopathogenesis of endometriosis still remains controversial—immune, hormonal, genetic, and epigenetic factors may be all involved, and several theories have been proposed to explain it.This book aims to summarize recent ground-breaking studies that may open new scenarios and change the perspective of the topic, including cutting-edge elements about diagnosis, pharmacologic and surgical treatments, as well as basic/translational science (immunology, cell biology, genetics, and epigenetics) pieces of evidence, to unravel new pathways to follow for the future diagnosis and management of endometriosis, and to improve our current knowledge of its aetiology.
    Keywords: BTG1 ; endometriosis ; human endometrial stromal cells ; endometrium ; uterus ; purinergic signaling ; ATP ; pathogenesis ; genetics ; epigenetics ; immunology ; ion channels ; etiology ; CFTR ; aquaporin ; chloride channels ; biomarker ; angiogenesis ; cytokines ; urinary biomarkers ; genetic polymorphisms ; SNPs ; aetiology ; Mediterranean population ; Sardinian population ; peritoneal fluid ; microenvironment ; precision medicine ; bic Book Industry Communication::M Medicine
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  • 36
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This Special Issue focuses on the current state of pharmacogenomics (PGx) and the extensive translational process, including the identification of functionally important PGx variation; the characterization of PGx haplotypes and metabolizer statuses, their clinical interpretation, clinical decision support, and the incorporation of PGx into clinical care.
    Keywords: pharmacogenomics ; return of results ; genetic counseling ; qualitative ; pharmacogenetics ; implementation ; pharmacogenetics service ; screening ; pre-emptive ; personalized medicine ; precision medicine ; community pharmacy ; pharmacogenomic testing ; genetic privacy ; pharmaco-economics ; polymorphisms ; pharmacogenes ; pharmacogenomic ; machine learning ; adaptation ; human evolution ; US Food and Drug Administration ; clinical actionability ; clinical translation ; chronic kidney disease ; CYP3A5 ; polymorphism ; progression ; pharmacogenomics (PGx) ; pediatrics ; best practice alerts (BPAs) ; electronic health records (EHR) ; genomic indicators ; clinical decision support (CDS) ; phenotype ; genotype ; polypharmacy ; chronic disease ; medication management ; electronic medical record ; artificial intelligence ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-08-12
    Description: This is a book on the practical approaches of reliability to electrotechnical devices and systems. It includes the electromagnetic effect, radiation effect, environmental effect, and the impact of the manufacturing process on electronic materials, devices, and boards.
    Keywords: 3D-IC (three-dimensional integrated circuit) ; electromagnetic interference ; near field measurement ; SAC305 ; BGA ; low temperature ; fracture failure ; factorial design of experiment ; genetic algorithm optimization ; return loss ; multiple-input multiple-output (MIMO) ; single event effects ; linear energy transfer ; Monte Carlo simulation ; radiation hardness ; pressureless sintered micron silver joints ; deep space environment ; extreme thermal shocks ; reconstruction ; simulation ; elastic mechanical properties ; state of health ; remaining useful life ; electrochemistry based electrical model ; semi-empirical capacity fading model ; useful life distribution ; quality and reliability assurance ; single event effect ; microdosimetry ; lineal energy ; deconvolution ; gamma process ; lifetime ; measurement system analysis ; reliability estimation ; GaN ; operational amplifier ; proton therapy ; prompt gamma imaging ; 3D X-ray ; bias temperature-humidity reliability test ; conductive anodic filament (CAF) ; de-penalization ; finite element analysis ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: In higher mammals, including primates and carnivores, the asymmetrical aspects of brain morphology and function have been shown to be species-related, sex-related, and subject to individual diversity, and are associated with cognition, emotion, language, preference of hand/paw use, and numerous other aspects. Disturbance of the brain lateralization is involved in human neurodevelopmental disorders with cognitive impairments, social deficits, and/or specific language impairments. Asymmetric development may be essential to the evolution of the brain in acquiring higher and/or more diverse functions. The purpose of this Special Issue on “Brain Asymmetry in Evolution” is to highlight morphological and functional lateralization of the brain in various species of mammals toward understanding the evolution of the brain.
    Keywords: oxyhemoglobin level ; state anxiety ; task performance ; heart rate ; human ; asymmetry ; sex difference ; MRI ; volumetry ; cerebellum ; ferret ; lateralization ; side bias ; fish ; methodological artefacts ; symmetry ; non-human primate ; Old World monkey ; evolution ; evolutionary expansion ; gyrification ; structural asymmetry ; language laterality ; topological data analysis ; persistent homology ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 39
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: This Special Issue includes papers on physical phenomena, such as wind-driven flows, coastal flooding, and turbidity currents, and modeling techniques, such as model comparison, model coupling, parallel computation, and domain decomposition. These papers illustrate the need for modeling coastal ocean flows with multiple physical processes at different scales. Additionally, these papers reflect the current status of such modeling of coastal ocean flows, and they present a roadmap with numerical methods, data collection, and artificial intelligence as future endeavors.
    Keywords: high performance computing ; HPC ; PETSc ; parallelization ; scalability ; parallel performance ; streams ; curvilinear ; non-hydrostatic ; ocean modeling ; GCCOM ; open boundaries ; domain decomposition ; variational data assimilation ; inverse problems ; shallow water equations ; boundary conditions ; mathematical modelling ; coastal ocean modelling ; computational methods ; hydrodynamic ; modeling ; sea level rise ; mobile application ; app ; crowdsourcing ; SCHISM ; Tidewatch ; StormSense ; Catch the King ; downstream blocking ; compound flooding ; coastal storm surge and inundation ; explosive lateral flooding ; hurricane inland and upland flooding ; coastal modelling ; operational forecasting ; model evaluation ; inter-comparison ; NEMO ; FVCOM ; Ocean Protection Plan ; turbidity current ; suspended sediment ; numerical model ; Gulf of Mexico ; cold front ; Hurricane Barry ; numerical simulation ; subtidal hydrodynamics ; multi-inlet ; volume flux ; multiscale ; multiphysics ; model coupling ; data collection ; machine learning ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 40
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-08-12
    Description: The Special Issue "Computational Intelligence Application in Electrical Engineering" deals with the application of computational intelligence techniques in various areas of electrical engineering. The topics of computational intelligence applications in smart power grid optimization, power distribution system protection, and electrical machine design and control optimization are presented in the Special Issue. The co-simulation approach to metaheuristic optimization methods and simulation tools for a power system analysis are also presented. The main computational intelligence techniques, evolutionary optimization, fuzzy inference system, and an artificial neural network are used in the research presented in the Special Issue. The articles published in this issue present the recent trends in computational intelligence applications in the areas of electrical engineering.
    Keywords: active distribution network ; computational intelligence ; optimization algorithms ; optimal distribution system management ; optimal Smart Grid management ; advanced distribution system optimization ; renewable distributed generation ; Smart Grid optimization ; co-simulation ; computational intelligence techniques ; distributed generation ; optimal allocation and control ; power system protection ; overcurrent relays ; protection relays ; metaheuristic ; school-based optimizer ; electric markets ; photovoltaic generation ; Monte Carlo simulations ; power flow ; S-iteration process ; Newton–Raphson ; high order newton-like method ; computational efficiency ; line-start synchronous motor ; efficiency factor ; power factor ; optometric analysis ; transient models ; induction machine ; ant colony optimization ; predictive current control ; fuzzy logic control ; Takagi–Sugeno ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 41
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This Special Issue publishes the latest advances and developments concerning the modelling of flooding in urban areas and contributes to our scientific understanding of the flooding processes and the appropriate evaluation of flood impacts. This issue contains contributions of novel methodologies including flood forecasting methods, data acquisition techniques, experimental research in urban drainage systems and/or sustainable drainage systems, and new numerical and simulation approaches in nine papers with contributions from over forty authors.
    Keywords: machine learning ; flash flood ; GIS ; Iran ; decision trees ; ensemble techniques ; manhole flooding ; urban flooding ; grid-based modeling ; SWWM ; FIRM ; pollutant transport ; hydraulic structures ; urban drainage ; CFD ; dual drainage ; Iber ; SWMM ; hazard ; artificial neural network ; resilient backpropagation ; multistep urban flood forecast ; demographic change ; urbanization ; flooding ; drainage system ; vulnerability ; Sub-Saharan Africa ; Antananarivo ; parameterised power-linear model ; hyper concentration ; dilute concentration ; suspended sediment transport ; flood ; sediment size parameter ; rouse number ; mean concentration ; flow depth ; urban flood modeling ; porosity ; shallow-water model ; urban flood management ; flood forecasting ; weather radar ; integrated hydraulic modeling ; and evacuation lead time ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 42
    Publication Date: 2022-11-17
    Description: Micro- and nano-molding technologies are continuously being developed due to enduring trends like increasing miniaturization and higher functional integration of products, devices, and systems. Furthermore, with the introduction of higher performance polymers, feedstocks, and composites, new opportunities in terms of material properties can be exploited, and, consequently, more micro-products and micro/nano-structured surfaces are currently being designed and manufactured.Innovations in micro- and nano-molding techniques are seen in the different processes employed in production (injection molding, micro injection molding, etc.); on the use of new and functional materials; for an ever-increasing number of applications (health-care devices, micro-implants, mobility, and communications products, optical elements, micro-electromechanical systems, sensors, etc.); in several key enabling technologies that support the successful realization of micro and nano molding processes (micro- and nano-tooling technologies, process monitoring techniques, micro- and nanometrology methods for quality control, simulation, etc.) and their integration into new manufacturing process chains.This Special Issue reprint showcases research papers and review articles that focus on the latest developments in micro-manufacturing and key enabling technologies for the production of both micro-products and micro-structured surfaces.
    Keywords: demolding process ; molecular dynamics simulation ; polypropylene ; injection molding ; nanostructure ; depth-to-width ratio ; air-shielding electrochemical micro-machining ; nozzle design ; flow field ; grey relational analysis ; optimization ; bistable mechanism ; V-beam structure ; compliant mechanism ; microinjection molding ; out-of-plane ; silicon photonics ; integrated optics ; waveguide crossing design ; multimode interference (MMI) ; sub-wavelength grating (SWG) ; multiplexing technology ; optical aspheric surface ; fast tool serve (FTS) ; machining error ; optical performance ; micro injection moulding ; adiabatic heating ; diesel effect ; venting ; film insert moulding ; surface analysis ; blister formation ; simulation ; semi-crystalline polymer ; PLLA ; thermoplastics ; microdevice ; direct-writing ; additive manufacturing ; micro manufacturing ; functionalization ; modeling ; micro-injection molding ; micro replication ; process simulation ; grating couplers ; integrated waveguide devices ; functional analysis ; micro-injection moulding ; machine design ; process capability ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 43
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: The development of materials from industrial wastes has attracted the attention of the research community for years. A material's physico-chemical characteristics have specific impacts its properties and their application in environmental, energetic, and biomedical areas, such as in pollutant removal; CO2 capture; energy storage; catalytic oxidation and reduction processes; the conversion of biomass to biofuels; and drug delivery. Examples of such materials are activated carbons, clays, and zeolites, among others. The aim of this Special Issue is to collect the recent advances and progresses developed in this field considering valorised materials from industrial wastes and their applications in environmental, energetic, and biomedical areas.
    Keywords: biomass gasification ; agricultural residues ; cogeneration plant ; life cycle assessment ; environmental impact ; greenhouse gas ; kinetics ; polyolefins ; aerobic biodegradation ; waste plastic materials ; biodegradation of plastic ; standard plastic testing ; gas explosion ; equivalent stoichiometric cloud ; Q9 ; explosion risk assessment ; model evaluation ; precoat layer ; precoat filtration ; cellulose fibres ; filter aids ; backwash filtration ; filter regeneration ; filter media resistance ; filter cake resistance ; turbidity ; particle layer ; LNG vapour ; dispersion ; hazard distances ; CFD ; topography ; phase change ; cold venting ; municipal solid waste ; SWDS ; composting process ; DOC ; IPCC guidelines ; GHG emissions ; wastewater treatment ; natural clays ; emerging contaminants ; zeolite ; bentonite ; Daphnia magna ; adsorption ; copper ; ion exchange ; thiourea ; X-ray photoelectron spectroscopy (XPS) ; reductive extraction ; resource recovery ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 44
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Improving the durability of reinforced concrete structures is a mandatory strategy to reduce the environmental impact of construction materials together with aiming to limit carbon dioxide emissions, energy consumption and natural raw materials depletion. Hence, for both new and existing concrete structures, proper protective techniques are required to prevent premature failure induced by environmental aggressive agents. The book presents the most innovative findings both in designing durable new constructions and toward solving durability deficiencies in existing concrete structures, such as innovative special coatings, hydrophobic impregnations and pore blocking treatments that are very efficient in severe aggressive environments (seawater, biocorrosion, etc.). Moreover, migrant corrosion inhibitors applied on concrete surfaces are able to greatly improve resistance against both chloride and CO2. Finally, special reinforcements and fibers, together with a proper designed cathodic protection, can greatly contribute to obtaining long-life reinforced concrete structures, significantly increasing the sustainability of concrete construction.
    Keywords: durability of concrete ; chloride penetration ; rebar corrosion ; corrosion inhibitor ; silane-based surface treatment ; concrete ; reinforcing steel ; zinc coating ; HDG ; corrosion ; chlorides ; LPR ; EIS ; SEM ; EDS ; geopolymer coatings (GPC) ; setting time ; compressive strength ; adhesive strength ; impermeability ; steel fiber reinforced concrete ; zinc phosphate ; chloride ion corrosion resistance ; microstructure ; bond strength ; pullout ; optical measurements ; 3D scanning ; electrochemical noise ; fly ash ; cathodic protection ; coatings ; durability ; concrete bio-corrosion ; sulfuric acid corrosion control ; magnesium hydroxide coating ; sewerage pipe systems ; acid spraying test ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 45
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: This text presents cutting-edge topics on and the diagnostic and therapeutic approaches for tear film abnormities, including dry eye disease and Meibomian gland dysfunction. A new management algorithm for Meibomian gland dysfunction, therapeutic eye drops and intense pulsed lasers for dry eye disease, and topical and systemic agents for neuropathic ocular pain are proposed in this issue.
    Keywords: cross-sectional study ; dry eye disease ; systemic comorbidity ; graves’ ophthalmopathy ; inflammation ; meibomian glands ; morphological changes ; meibomian gland dysfunction ; ocular surface disease ; dry eye symptoms ; questionnaire ; Bangladesh ; global health ; epidemiology ; aqueous-deficient dry eye ; meibomian gland ; intense pulsed light ; severe keratitis ; hyaluronan ; hylan A ; multicenter ; randomized trial ; gabapentin ; dry eye ; neuropathic pain ; diabetes ; neuropathic keratopathy ; neuropathy ; nerve growth ; neurotrophic ; Houttuynia ; ultrasonic atomization ; meibography ; meiboscore ; TRPM8 agonist ; cryosim-3 ; fatty acids ; vitamin D ; brief-type self-administered diet history questionnaire ; Japanese ; bic Book Industry Communication::M Medicine
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  • 46
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-24
    Description: Natural products or organic compounds isolated from natural sources as primary or secondary metabolites have inspired numerous drugs. It is not an overstatement that the majority of medicines in clinics, even in the 21st century, have been derived from natural resources despite the decline of industry research into natural products due to a variety of drawbacks. Saffron crocus, considered to be the most valuable spice by weight, and its bioactive constituents, have been studied for the treatment of a wide range of pathologies, including neuropsychiatric and neurodegenerative disorders, cancer, diabetes, and even cardiovascular diseases. In this book on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents, we aimed to assess new advances in the understanding of the therapeutic action of saffron and its constituents in targeting different pathologies. In this context, eight original research articles covering recent advances in the therapeutic actions of saffron and its ingredients in different diseases are reported. Two studies reporting novel methods regarding the bioanalysis of saffron extracts have been included. The collection is completed with two very interesting reviews reporting advances in the fields of schizophrenia and cancer. In conclusion, in this book, we are delighted to have received several contributions that we hope will provide new and interesting information for the scientific community on the chemistry, pharmacology, and therapeutic potential of Crocus sativus L. extract and its constituents.
    Keywords: saffron ; affron® ; depression ; anxiety ; antioxidant ; crocins ; glucose ; β-pancreatic cells ; insulin ; pck1 ; neuroprotective activity ; P2X7 receptor ; fraction ; flumazenil ; rat ; Crocus sativus ; cancer ; anticancer activity ; chemoprevention ; clinical trials ; patents ; anesthetic ketamine ; memory ; Crocus sativus L. ; schizophrenia ; crocetin ; pubertal testis ; X-rays ; radiotherapy ; fertility preservation ; SIRT1 ; HuR ; oxidative stress ; autophagy ; crocin ; picrocrocin ; safranal ; dietary supplement ; nutraceutical ; Crocus sativus L. (Iridaceae) ; reversed-phase UPLC ; metabolomics ; HR MS ; inflammatory bowel disease ; gut microbiota ; colitis ; cytokines ; colorectal cancer ; HCT116 ; MLH1 ; MSH3 ; DNA damage and repair ; apoptosis ; n/a ; bic Book Industry Communication::M Medicine
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  • 47
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: In the past few years, knowledge about glaucoma diagnosis and follow up has evolved dramatically through advances in intraocular pressure (IOP) measurement, corneal biomechanics, structural and functional assessment of the ocular surface, anterior chamber, retina, optic nerve and intracranial visual pathways, as well as the advent of artificial intelligence. In addition, the development of new modalities of IOP-lowering and non-IOP-lowering drugs, alternative deliveries, refined laser technologies, and minimally invasive glaucoma surgery (MIGS) techniques with different implants have widened the therapeutic possibilities for treating this disease. Finally, current insights into risk factors and quality of life in relation to glaucomatous impairment are emerging. The purpose of this Special Issue is to present the latest exciting clinical developments that are taking place in the field of glaucoma.
    Keywords: ripasudil ; suture trabeculotomy ab interno ; Schlemm’s canal incision ; aqueous outflow ; open-angle glaucoma ; glaucoma ; inflammation ; oxidative stress ; phenotype ; polymorphism ; susceptibility ; intraocular pressure ; ocular inflammation ; cornea biomechanics ; Corvis® ST ; subclinical keratoconus ; ocular hypertension ; tears ; miRNAs ; next generation sequencing ; biomarkers ; genes ; signaling pathways ; apoptosis ; neurodegeneration ; glaucoma suspect ; lamina cribrosa ; optical coherence tomography angiography ; peripapillary vessel density ; OCTA ; vessel density ; disc ; peripapillary ; NTG ; BRVO ; corneal hysteresis ; corneal biomechanics ; ocular biomarkers ; deep learning ; perimetry ; optic nerve ; obesity ; risk factor ; young adults ; multifocal visual evoked potentials ; mfVEP ; physical exercise ; sport ; acrobatic gymnastics ; baseline intraocular pressure ; central corneal thickness ; ocular health ; tumbling skills ; hand balance ; cytokines ; BDNF ; VEGF ; fractalkine ; microglia ; saffron ; crocin ; retinal glial cells ; microperimetry ; OCT ; macula ; structure ; function ; correlation ; retina ; inner ; outer ; macular segmentation ; optical coherence tomography-angiography ; vascular density ; blood flow ; biomarker ; myopia ; n/a ; bic Book Industry Communication::M Medicine
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  • 48
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-24
    Description: This special issue on the genetics of Alzheimer's disease was edited by Drs. Laura Ibanez and Justin Miller in 2021. It contains 10 original articles and reviews that help readers understand specific genetic contributions to Alzheimer's disease and how genetics will play a role in future Alzheimer's disease research.
    Keywords: Alzheimer disease ; expression quantitative trait loci (eQTL) ; rare variants ; set-based eQTL ; SKAT-O ; pathways ; immune system ; inflammation ; ROSMAP ; ADNI ; complement ; complement receptor 1 ; clusterin ; late-onset Alzheimer’s disease ; genetics ; neuroinflammation ; Alzheimer’s disease ; cytokines and growth factors ; genome-wide association study (GWAS) ; Polygenic Risk Score (PRS)-based analysis ; TOMM40 gene ; RNA transcription ; pseudogene ; mitochondrial dysfunction ; ITIM ; ITAM ; SIGLEC14 ; SIGLEC5 ; copy number variation ; CNV ; GWAS ; long non-coding RNA ; biomarkers ; peripheral system ; amyloid β ; tau ; APOE ; TREM2 ; OMICS ; therapeutics ; pairwise feature correlation ; feature reduction ; machine learning ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 49
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This book is a compilation of original research articles that apply a variety of techniques to identify and evaluate water resource management policies. These papers cover a wide range of topics and methodologies applied across the world, from a local to a continental scope. They illustrate open challenges in water resource management, such as the quantitative assessment of policy impacts, trade-off analyses, understanding the water–energy–food–environment nexus, collaborative model development, stakeholder engagement, formalizing social interactions, or improving the theoretical understanding of complex adaptive systems. Therefore, this book is a representation of research areas that have emerged from the origins of water resource systems analysis, seeking to improve the way in which water policy is formulated and implemented.
    Keywords: climate change ; water resources ; water availability ; uncertainty ; WAAPA model ; Western Europe ; water quality ; background pollutants ; export coefficient model ; chemical oxygen demand ; ammonia nitrogen ; water resource accessibility ; spatial pattern ; coupling coordination degree ; water resource management ; Southwest China ; pump efficiency ; water distribution systems ; water supply systems ; optimization ; design policies ; design ; BMPs ; Revised GWLF ; NSGAII ; hydrological dam safety ; initial reservoir level ; maximum conservation level ; water conservation volume ; flood control volume ; yield reliability ; regular operation ; stochastic methodology ; water management ; resources ; system dynamics ; drought management ; drought impacts ; urban public services ; inter-administrative cooperation ; border studies ; internal borders ; river municipalities ; freshwater health ; river chief system ; ecological integrity ; social services ; water governance ; national standard ; risk assessment ; water-saving ; set pair analysis ; China ; fluvial ecosystems ; hydropeaking ; InSTHAn tool ; short-term flow regimes ; subdaily flows ; sustainable river management ; droughts ; hydrological risk ; agri-food sector ; event study ; financial markets ; BOVESPA ; stormwater ; industrial facilities ; run off ; self-reported data ; multifunctional water source area ; ecotourism, people with different stakeholders ; balanced decision-making ; sponge city ; fuzzy comprehensive evaluation method ; water resource carrying capacity ; gray correlation analysis ; multiple linear regression models ; water environment capacity ; reservoir performance ; water resources systems ; participatory modeling ; river basin planning ; watershed management ; water scarcity ; water conflicts ; Robust Decision Support ; WEAP ; Integrated Water Resources Management ; Bolivia ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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  • 50
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-07-06
    Description: This book focuses on a variety of interdisciplinary perspectives concerning the theory and application of artificial intelligence (AI) in medicine, medically oriented human biology, and healthcare. The list of topics includes the application of AI in biomedicine and clinical medicine, machine learning-based decision support, robotic surgery, data analytics and mining, laboratory information systems, and usage of AI in medical education. Special attention is given to the practical aspect of a study. Hence, the inclusion of a clinical assessment of the usefulness and potential impact of the submitted work is strongly highlighted.
    Keywords: computational intelligence ; medical assistance ; instance-based learning ; healthcare ; clinical decision support systems ; deep neural networks ; medical imaging ; backdoor attacks ; security and privacy ; COVID-19 ; gastric cancer ; endoscopy ; deep learning ; convolutional neural network ; brain ; pituitary adenoma ; dysembryoplastic neuroepithelial tumor ; DNET ; ganglioglioma ; digital pathology ; computer vision ; machine learning ; CNN ; ATLAS ; HarDNet ; Swin transformer ; segmentation ; U-Net ; cerebral infarction ; CycleGAN ; advanced statistics ; schizophrenia ; aggression ; forensic psychiatry ; medical image segmentation ; CT image segmentation ; kernel density ; semi-automated labeling tool ; Bayesian learning ; neuroimaging ; feature selection ; kernel formulation ; mental disorders ; MRI ; visual acuity ; fundus images ; ophthalmology ; SVM ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: In the last decade, research on cold atmospheric plasma (CAP) has significantly advanced our understanding of the effect of CAP on cancer cells and their potential for cancer treatment. This effect is due to the reactive oxygen and nitrogen species (RONS) created by plasma. This has been demonstrated for different cancer cell lines and the first clinical trials showed promising results. In addition, plasma could be combined with other treatments—such as immunotherapy—to boost its anticancer activity. The addition of new research tools to study the response of cancer cells to CAP—such as 3D in vitro, in ovo, and in vivo models and in silico approaches—as well as the use of -OMICS technologies could aid in unravelling the underlying mechanisms of CAP in cancer treatment. In order to progress towards widespread clinical application of CAP, an integrated study of the multidimensional effect of CAP in cancer treatment is essential. In this book, reviews and original research papers are published that provide new insights into the mechanisms of cold atmospheric plasma in cancer treatment, based on in vitro and in vivo experiments, clinical studies, as well as computer modeling.
    Keywords: cell adhesion ; plasma medicine ; oncology ; cold atmospheric plasma ; selectivity ; plasma-treated liquid ; dielectric barrier discharge ; pancreatic cancer ; pancreatic stellate cells ; immunogenic cell death ; dendritic cells ; cell communication ; extracellular matrix (ECM) ; reactive oxygen and nitrogen species (ROS) ; tumour microenvironment (TME) ; extracellular vesicles ; communication junctions ; three-dimensional in vitro culture models ; apoptosis ; breast cancer ; genome-wide expression ; reactive oxygen species ; anticancer drugs ; screening ; tumor spheroids ; combination therapy ; kINPen ; reactive oxygen and nitrogen species ; ROS ; cancer ; non-thermal atmospheric pressure plasma (NTP) ; indirect treatment ; plasma-treated phosphate-buffered saline ; electroporation ; electric pulses ; pulsed electric field amplitude ; melanoma ; long-lived reactive species ; bone cancer ; osteosarcoma ; reactive species ; plasma-activated liquid ; Ringer’s saline ; organotypic model ; nonthermal biocompatible plasma ; soft jet plasma ; human glioblastoma ; p38/MAPK pathway ; tissue penetration ; non-thermal plasma ; non-invasive plasma treatment (NIPP) ; cervical intraepithelial neoplasia (CIN) ; Raman imaging ; Raman microspectroscopy ; Plasma lipid interactions ; cold physical plasma ; radiation therapy ; radio-frequency discharge ; PARP-inhibitor ; olaparib ; DNA-damage ; gold quantum dots ; plasma ; nanomaterials ; cellular uptake ; invasiveness ; cold atmospheric pressure plasma ; plasma-activated Ringer’s lactate solution ; ovarian cancer ; cytotoxicity ; plasma-activated liquids ; multicellular tumor spheroids ; long-lived reactive oxygen and nitrogen species ; high frequency electrosurgery ; plasma treatment ; cold atmospheric plasma (CAP) ; free radicals ; cancer selectivity ; cervical cancer treatment ; cervical intraepithelial neoplasia ; cholangiocarcinoma ; cold plasma ; innovative therapy ; tumor cells ; macrophages ; plasma selectivity ; plasma jet ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Connected and automated vehicles (CAVs) are a transformative technology that is expected to change and improve the safety and efficiency of mobility. As the main functional components of CAVs, advanced sensing technologies and control algorithms, which gather environmental information, process data, and control vehicle motion, are of great importance. The development of novel sensing technologies for CAVs has become a hotspot in recent years. Thanks to improved sensing technologies, CAVs are able to interpret sensory information to further detect obstacles, localize their positions, navigate themselves, and interact with other surrounding vehicles in the dynamic environment. Furthermore, leveraging computer vision and other sensing methods, in-cabin humans’ body activities, facial emotions, and even mental states can also be recognized. Therefore, the aim of this Special Issue has been to gather contributions that illustrate the interest in the sensing and control of CAVs.
    Keywords: TROOP ; truck platooning ; path planning ; kalman filter ; V2V communication ; string stability ; off-tracking ; articulated cargo trucks ; kabsch algorithm ; potential field ; sigmoid curve ; autonomous vehicles ; connected and autonomous vehicles ; artificial neural networks ; end-to-end learning ; multi-task learning ; urban vehicle platooning ; simulation ; attention ; executive control ; simulated driving ; task-cuing experiment ; electroencephalogram ; fronto-parietal network ; object vehicle estimation ; radar accuracy ; data-driven ; radar latency ; weighted interpolation ; autonomous vehicle ; urban platooning ; vehicle-to-vehicle communication ; in-vehicle network ; analytic hierarchy architecture ; traffic scenes ; object detection ; multi-scale channel attention ; attention feature fusion ; collision warning system ; ultra-wideband ; dead reckoning ; time to collision ; vehicle dynamic parameters ; Unscented Kalman Filter ; multiple-model ; electric vehicle ; unified chassis control ; unsprung mass ; autonomous driving ; trajectory tracking ; real-time control ; model predictive control ; tyre blow-out ; yaw stability ; roll stability ; vehicle dynamics model ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: A rigorous examination of the most recent advancements in blockchain technology (BCT) and artificial intelligence (AI)-enabled supply chain networks is provided in this book. The edited book brings together the perspectives of a number of authors who have presented their most recent views on blockchain technology and its applications in a variety of disciplines. The submitted papers contribute to a better understanding of how blockchain technology can improve the efficacy of human activities during a pandemic, improve traceability and visibility in the automotive supply chain, support food safety and reliability through digitalisation of the food supply chain, and increase the performance of next-generation digital supply chains, among other things. The book attempts to address and prepare a way to address the complicated issues that supply chains are encountering as a result of the global pandemic.
    Keywords: sustainable agricultural supply chain management ; web design elements ; blockchain ; variable demand ; cooperative advertisement ; uncertain environment ; supply chain ; digitalization ; Ethereum blockchain ; IPFS ; COVID-19 pandemic ; visibility ; transparency ; smart contracts ; sustainability ; supply chain management ; literature review ; automotive supply chains ; simulation ; case study ; Industry 4.0 ; humanitarian activities (HAs) ; humanitarian organization (HO) ; pandemic disruption ; COVID-19 ; blockchain-enabled digital humanitarian networks (BT-DHN) ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: An outstanding compilation that reflects the state-of-the art on Dielectrophoresis (DEP) in 2020. Contributions include: - A novel mathematical framework to analyze particle dynamics inside a circular arc microchannel using computational modeling. - A fundamental study of the passive focusing of particles in ratchet microchannels using direct-current DEP. - A novel molecular version of the Clausius-Mossotti factor that bridges the gap between theory and experiments in DEP of proteins. - The use of titanium electrodes to rapidly enrich T. brucei parasites towards a diagnostic assay. - Leveraging induced-charge electrophoresis (ICEP) to control the direction and speed of Janus particles. - An integrated device for the isolation, retrieval, and off-chip recovery of single cells. - Feasibility of using well-established CMOS processes to fabricate DEP devices. - The use of an exponential function to drive electrowetting displays to reduce flicker and improve the static display performance. - A novel waveform to drive electrophoretic displays with improved display quality and reduced flicker intensity. - Review of how combining electrode structures, single or multiple field magnitudes and/or frequencies, as well as variations in the media suspending the particles can improve the sensitivity of DEP-based particle separations. - Improvement of dielectrophoretic particle chromatography (DPC) of latex particles by exploiting differences in both their DEP mobility and their crossover frequencies.
    Keywords: dielectrophoresis (DEP) ; microparticles ; polystyrene ; chromatography ; interdigitated electrodes ; microfluidic ; separation ; electrowetting display ; driving waveform ; aperture ratio ; exponential function ; time constant ; single-cell microfluidics ; single-cell recovery ; single-cell array ; hydrodynamic trapping ; electrokinetics ; tridimensional electrodes ; mRNA sequencing ; Drop-seq ; induced charge electrophoresis (ICEP) ; Janus particles ; optical trapping ; phase-sensitive detection ; phoretic force spectroscopy ; ICEP motility reversal ; micro-robotics ; dielectrophoresis ; microfluidics ; cell separation ; electrokinetic ; particle focusing ; electrophoretic display ; particle activation ; response speed ; reference grayscale ; cell immobilization ; lab-on-a-chip ; Clausius–Mossotti function ; dielectric spectroscopy ; interfacial polarization ; proteins ; sleeping sickness ; Human African trypanosomiasis ; trypanosoma ; titanium ; curvature-induced ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-07-06
    Description: Reactive oxygen species (ROS) are produced by healthy cells and are maintained at physiological levels by antioxidant systems. However, when ROS increase in number, a condition of oxidative stress occurs, leading to many human diseases, including cancer. The relationship between oxidative stress and cancer is complex since ROS play a double-edged role in cancer development and under therapy response. This paradox represents a great challenge for researchers and needs to be investigated. The articles collected in this Special Issue can help to clarify the role of ROS modulation in cancer prevention and treatment, and to dissect the molecular mechanisms underlying its paradoxical role in order to counteract carcinogenesis or enhance sensitivity to anticancer therapy.
    Keywords: sonodynamic therapy ; carbon doped titanium dioxide ; sonosensitizers ; ultrasound ; cancer treatment ; breast cancer treatment ; radiotherapy ; hematological malignancies ; oxidative stress ; lymphoma ; leukemia ; multiple myeloma ; apoptosis ; mitochondria ; ultraviolet-C (UVC) ; withanolide ; combined treatment ; oral cancer ; DNA damage ; cancer therapy ; immune system ; Hypericum perforatum ; hyperforin ; reactive oxygen species ; pH regulation ; tumor prevention ; tumor therapy ; cancerogenesis ; inflammatory signaling ; natural compounds ; pancreatic cancer ; antitumor agents ; coordination polymers ; bioinorganic chemistry ; cold atmospheric plasma ; reactive oxygen and nitrogen species ; nitrite ; cancer stem cells ; chemoresistance ; glutathione ; lipid peroxidation ; ZEB-1 ; GPX4 ; ferroptosis ; HO-1 ; Nrf2 ; cancer progression ; patients ; therapy ; prognosis ; biomarker ; Eprenetapopt ; Erastin ; glutathione (GSH) ; SLC7A11 ; iron ; NRF2 ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: This book includes articles written by over 80 specialists from many countries that demonstrate the biological functions of ultrasonic vocalizations and how they are used in studies of vocal expression of emotional states and in numerous animal models of neuropsychiatric diseases and disorders. Results of investigations of emissions of ultrasonic vocalizations are useful in studies of emotional disturbances, affective disorders, autism spectrum disorders, addiction, developmental abnormalities, and many other pathologies.
    Keywords: ultrasonic vocalization ; maternal immune activation ; autism ; communication ; rat ; sex differences ; social play ; rats ; anxiety ; observational fear learning ; USV ; maternal separation ; pup ; vasopressin antagonists ; righting reflex ; negative geotaxis ; ACTH ; corticosterone ; Brattleboro rat ; larynx ; female ; male ; 50-khz ultrasonic vocalizations (USVs) ; individual differences ; chronic variable stress (CVS) ; dopamine ; nucleus accumbens ; microdialysis ; evolution of vocalization ; 22 kHz calls ; 50 kHz calls ; infant isolation calls ; emotional arousal ; mesolimbic dopaminergic system ; mesolimbic cholinergic system ; hedonia ; ultrasonic vocalizations ; cognitive development ; respiration ; brain oscillations ; Cav1.2 ; calcium ; animal model ; rough-and-tumble play ; social approach ; playback ; social contact call ; alarm call ; social buffering ; distress ; emotional contagion ; fear contagion ; aversive state ; automated scoring ; addiction ; mental health ; machine learning ; drug discovery ; drug development ; Parkinson’s disease ; alpha-synuclein ; 6-OHDA ; Pink1 ; DJ1 ; exercise ; pharmacology ; pathology ; hypervigilance ; hyperreactivity ; exaggerated reactivity ; generalization ; PTSD ; depression ; heart rate ; Wistar ; 22-kHz calls ; 50-kHz calls ; affect ; aversion ; NOR ; reward ; working memory ; Y maze ; opioids ; fentanyl ; self-administration ; play ; food ; dam–pup interaction ; ethanol ; pup isolation ; rat pup ; 50 kHz vocalizations ; 22 kHz vocalizations ; amphetamine ; chemogenetics ; clozapine-n-oxide ; UMAP ; males ; females ; vocalizations ; fear extinction ; pain ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: The deployment of distributed renewable energy resources (DRERs) has accelerated globally due to environmental concerns and an increasing demand for electricity. DRERs are considered to be solutions to some of the current challenges related to power grids, such as reliability, resilience, efficiency, and flexibility. However, there are still several technical and non-technical challenges regarding the deployment of distributed renewable energy resources. Technical concerns associated with the integration and control of DRERs include, but are not limited, to optimal sizing and placement, optimal operation in grid-connected and islanded modes, as well as the impact of these resources on power quality, power system security, stability, and protection systems. On the other hand, non-technical challenges can be classified into three categories—regulatory issues, social issues, and economic issues. This Special Issue will address all aspects related to the integration and control of distributed renewable energy resources. It aims to understand the existing challenges and explore new solutions and practices for use in overcoming technical challenges.
    Keywords: distribution system ; microgrids ; power quality ; power system management ; power system reliability ; smart grids ; distribution networks ; Monte Carlo simulations ; PV hosting capacity ; photovoltaics ; green communities ; energy independence ; HOMER ; wind turbines ; power losses ; power system optimization ; PV curves ; DG ; TSA/SCA ; solar-powered electric vehicle parking lots ; different PV technologies ; PLO’s profit ; uncertainties ; smart grid paradigm ; distributed generation ; model-based predictive control ; robustness ; worst-case scenario ; min–max optimisation ; intraday forecasting ; Gaussian process regression ; machine learning ; off-grid system ; composite control strategy ; solar photovoltaic panel ; wind turbine ; diesel generator ; energy storage system (ESS) ; synchronous machine (SM) ; permanent magnet brushless DC machine (PMBLDCM) ; power quality improvement ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: Engineering and business problems are becoming increasingly difficult to solve due to the new economics triggered by big data, artificial intelligence, and the internet of things. Exact algorithms and heuristics are insufficient for solving such large and unstructured problems; instead, metaheuristic algorithms have emerged as the prevailing methods. A generic metaheuristic framework guides the course of search trajectories beyond local optimality, thus overcoming the limitations of traditional computation methods. The application of modern metaheuristics ranges from unmanned aerial and ground surface vehicles, unmanned factories, resource-constrained production, and humanoids to green logistics, renewable energy, circular economy, agricultural technology, environmental protection, finance technology, and the entertainment industry. This Special Issue presents high-quality papers proposing modern metaheuristics in intelligent systems.
    Keywords: matheuristics ; hyperheuristics ; vehicle routing ; wireless networking ; green energy ; low carbons&nbsp ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: With the increasing global usage of water and the continuous addition of contaminants to water sources, new challenges have arisen that are associated with the abatement of organic pollutants, particularly those that are refractory to conventional water and wastewater treatment technologies. Advanced oxidation processes (AOPs) present a competitive alternative to promote the oxidation of organic contaminants by strong oxidative radicals generated from oxygen, ozone, wet peroxide, and UV radiation. The use of catalysts not only improves efficiency but may present remarkable cost advantages for practical applications of AOPs in the abatement of several pollutants. In this Special Issue of Catalysts, we invite authors to submit original research papers focused on the synthesis and characterization of novel heterogeneous catalysts and their uses in advanced oxidation processes for the removal of organic pollutants from aqueous solutions.
    Keywords: CdS ; Bi2MoO6 microspheres ; antibiotic removal ; charge separation ; visible-light-driven ; carbon xerogel ; carbon nanotubes ; activated carbon ; adsorption ; catalytic wet peroxidation ; heterogeneous Fenton’s oxidation ; p-nitrophenol ; magnetic materials ; chemical vapour deposition ; photocatalytic ozonation ; organic pollutants ; advanced oxidation process ; wastewater treatment ; contaminants of emerging concern ; pharmaceuticals ; environmental catalysis ; biochar ; iron mineral ; heterogeneous catalysts ; antibiotic ; advanced oxidation processes ; water treatment ; Fenton reactions ; LCA ; environmental impact ; Fenton ; photocatalysis ; visible light ; SBA15 ; magnetite ; graphene ; tin oxide ; antimony doped tin oxide ; electrochemical oxidation ; atomic layer deposition ; TiO2-SiO2 ; immobilized photocatalyst ; methylene blue adsorption ; metal-free carbon catalysts ; N, S-co-doping ; catalytic wet air oxidation ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: This reprint presents various aspects of the future grid, which is the next generation of the electrical grid and will enable the smart integration of conventional, renewable, and distributed power generation, energy storage, transmission and distribution, and demand management. Renewable energy is crucial in transitioning to a less carbon-intensive economy and a more sustainable energy system. The high penetration and uncertain power outputs of renewable energy pose great challenges to the stable operation of energy systems. The deployment of the smart grid is revolutionary, and also imperative around the world. It involves and deals with multidisciplinary fields such as energy sources, control systems, communications, computational generation, transmission, distribution, customer operations, markets, and service providers. Smart grids are emerging in both developed and developing countries, with the aim of achieving a reliable and secure electricity supply. Smart grids will eventually require standards, policy, and a regulatory framework for successful implementation. This reprint addresses the emerging and advanced green energy technologies for a sustainable and resilient future grid, and provides a platform to enhance interdisciplinary research and share the most recent ideas.
    Keywords: islanded mode ; microgrid ; decentralized control ; robust tracking ; invariant set ; thermal energy storage ; parabolic dish ; latent heat ; phase change material ; heat transfer fluid ; bio-inspired algorithms ; wireless sensor network ; genetic algorithm ; particle swarm optimization ; advanced metering infrastructure ; blockchain ; Ethereum ; isolated DC–DC converter ; photovoltaics ; LLC resonant converter ; dual-bridge ; wide voltage range ; power optimizer ; coordinated control ; vehicle-to-grid ; primary frequency control ; secondary frequency control ; state of charge ; decentralized ; Simulink model ; dimensionality reduction ; simple linear regression ; multiple linear regression ; polynomial regression ; load forecasting ; VSC (voltage source converter) ; PLL (Phase-Locked Loop) ; weak grid ; small signal stability ; eigenvalues ; demand-side management ; low-power consumer electronic appliances ; low-voltage distribution system ; non-intrusive identification of appliance usage patterns ; power quality ; smart home ; true power factor ; total harmonic distortion ; renewable energy sources ; energy management system ; communication technologies ; microgrid standards ; third-order sliding mode control ; asynchronous generators ; variable speed dual-rotor wind turbine ; direct field-oriented control ; integral-proportional ; transformer ; internal fault currents ; magnetic inrush currents ; extended Kalman filter (EKF) algorithm ; harmonic estimation ; DC microgrid ; fault ; cluster ; DC/DC converter ; fault current limiter (FCL) ; multi-objective ; renewable energy ; profit-based scheduling ; Equilibrium Optimizer ; smart grid ; campus microgrid ; batteries ; prosumer market ; distributed generation ; renewable energy resources ; energy storage system ; distributed energy resources ; demand response ; load clustering techniques ; sizing methodologies ; digital signal processing ; green buildings ; spectral analysis ; spectral kurtosis ; life-cycle cost ; optimal scheduling ; reinforcement learning ; enabling technologies ; energy community ; smart meter ; nanogrid ; platform ; power cloud ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: This Special Issue is a book composed by collecting documents published through peer review on the research of various advanced technologies related to applications and theories of signal processing for multimedia systems using ML or advanced methods. Multimedia signals include image, video, audio, character recognition and optimization of communication channels for networks. The specific contents included in this book are data hiding, encryption, object detection, image classification, and character recognition. Academics and colleagues who are interested in these topics will find it interesting to read.
    Keywords: data hiding ; AMBTC ; BTC ; Hamming code ; LSB ; predicate encryption ; inner product encryption ; constant-size private key ; efficient decryption ; constant pairing computations ; watermarking ; self-embedding ; digital signature ; fragile watermarking ; constrained backtracking matching pursuit ; sparse reconstruction ; compressed sensing ; greedy pursuit algorithm ; image processing ; visual surveillance ; deep learning ; object detection ; latency optimization ; mobile edge cloud ; connected autonomous cars ; smart city ; video surveillance ; physical layer security ; secure transmission ; secrecy capacity ; secrecy capacity optimization artificial noise ; power allocation ; channel estimation error ; neural network ; transfer learning ; scalograms ; MFCC ; Log-mel ; pre-trained models ; seismic patch classification ; CNN-features ; data complexity ; handwritten text recognition ; Residual Network ; Transformer model ; named entity recognition ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: This book includes 17 papers published in the Special Issue/Article Collectoin “New Insights in the Genetics and Genomics of adrenocortical tumors and pheochromocytomas” including an editorial, 10 research papers and six review articles. Adrenal tumors represent a hot topic in contemporary endocrine oncology. Significant advancements in the genetics of genomics of these tumors have been made in recent years, and these articles give a useful and comprehensive overview of these issues. Questions regarding molecular pathogenesis, diagnosis (biomarkers) and even treatment are discussed in the papers written by international leaders of the field. Manuscripts are focused on three main topics: i. primary aldosteronism (the most common cause of secondary endocrine hypertension), ii. adrenocortical cancer and iii. pheochromocytoma/paraganglioma, which are the tumors with the highest heritability in humans. The book is edited by Prof. Peter Igaz (Department of Endocrinology, Faculty of Medicine, Semmelweis University).
    Keywords: pheochromocytoma ; paraganglioma ; genetics ; non-coding RNA ; malignancy ; biomarker ; treatment ; adaptive metabolism ; adrenal gland ; conn adenoma ; fatty acid metabolism ; ferroptosis ; hyperaldosteronism ; metabolic reprogramming ; β-oxidation ; PPARα ; tumor microenvironment ; Next Generation Sequencing ; hereditary cancer ; endocrine tumor syndrome ; KCNJ5 somatic mutation ; pulse wave velocity ; aldosterone-producing adenoma ; adrenalectomy ; propensity score matching ; arterial stiffness ; pheochromocytomas ; paragangliomas ; mutations ; susceptibility genes ; driver mutations ; hereditary ; germline ; somatic ; environment ; variants ; tumor suppressor genes ; metastatic ; RNAseq ; next generation sequencing ; adrenocortical carcinoma ; in silico analysis ; machine learning ; bioinformatic clustering ; biomarker prediction ; aldosterone producing adenoma ; ATP2B3 ; K416-F418delinsN mutation ; primary aldosteronism ; PPGL ; telomeres ; TERT ; ATRX ; NOP10 ; prognostic biomarker ; ALT ; phaeochromocytoma ; cancer ; mitochondrial complex II ; zebrafish ; therapy ; drug discovery ; redox balance pathway ; Vitamin C ; mitotane ; H295 strains ; microRNA ; aldosterone ; circulating ; adrenocortical ; transcriptomics ; epigenetics ; metabolomics ; epidemiology ; genetic analysis ; mortality ; surveillance ; TP53 R337H ; genetic testing ; adrenocortical tumor ; neonatal screening ; screening ; adenoma ; adrenal ; tissue ; artificial intelligence ; neural network ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: Using hyperspectral imaging (HSI) to exploit data has been found in a wide variety of applications. This reprint book only presents a small glimpse of it. Many other important applications using HSI which have emerged in data exploitation are not covered in this reprint book. For example, such applications may include water pollution and toxic waste in environmental monitoring, pesticide residual detection in food safety and inspection, plant and crop disease detection in agriculture, tumor detection and breast cancer detection in medical imaging, drug traffic in law enforcement, etc. Nevertheless, this reprint book provides many techniques which may find their ways in these applications as well.
    Keywords: hyperspectral image few-shot classification ; deep learning ; meta-learning ; relation network ; convolutional neural network ; constrained-target optimal index factor band selection (CTOIFBS) ; hyperspectral image ; underwater spectral imaging system ; underwater hyperspectral target detection ; band selection (BS) ; constrained energy minimization (CEM) ; lightweight convolutional neural networks ; hyperspectral imagery classification ; transfer learning ; air temperature ; spatial measurement ; FTIR ; MWIR ; carbon dioxide absorption ; target detection ; coffee beans ; insect damage ; hyperspectral imaging ; band selection ; visualization ; color formation models ; multispectral image ; image fusion ; joint tensor decomposition ; anomaly detection ; constrained sparse representation ; hyperspectral imagery ; moving target detection ; spatio-temporal processing ; hyperspectral remote sensing ; image classification ; constraint representation ; superpixel segmentation ; multiscale decision fusion ; plug-and-play ; denoising ; nonlinear unmixing ; spectral reconstruction ; residual augmented attentional u-shape network ; spatial augmented attention ; channel augmented attention ; boundary-aware constraint ; atmospheric transmittance ; temperature ; emissivity ; separation ; midwave infrared ; hyperspectral images ; hyperspectral image super-resolution ; data fusion ; spectral-spatial residual network ; self-supervised training ; hyperspectral ; vegetation ; generative adversarial network ; data augmentation ; classification ; rice leaf blast ; hyperspectral imaging data ; deep convolutional neural networks ; fused features ; evolutionary computation ; heuristic algorithms ; machine learning ; unmanned aerial vehicles (UAVs) ; vegetation mapping ; upland swamps ; mine environment ; rice ; rice leaf folder ; hyperspectral image classification ; change detection ; self-supervised learning ; attention mechanism ; multi-source image fusion ; SFIM ; least square estimation ; spatial filter ; hyperspectral imaging (HSI) ; hyperspectral target detection ; hyperspectral reconstruction ; hyperspectral unmixing ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Droughts are one of the main extreme meteorological, and hydrological phenomena, which influence both the functioning of ecosystems, and many important sectors of human economic activity. Throughout the world, various direct changes in meteorological, and climatic conditions, such as: air temperature, humidity, and evapotranspiration can be observed. They have a significant influence upon the shaping of the phenomenon of drought. Land cover and land use can also be indirect factors influencing evapotranspiration, and, by the same token, the water balance in the water catchment area. They can also influence the course of the process of the drought. The observed climate change, manifested mainly by increases in temperature, in turn, influencing evapotranspiration, may cause intensification in terms of both the degree and frequency of droughts. Droughts related to changes in the hydrological regime, and to the decrease in water resources. Its results can be observed in various sectors, related, among others, to a demand for water for people, agriculture and the Industry. It can also prove problematic for water ecosystems. To reflect the aforementioned information, a reasonable drought risk management is indispensable in order to ease the water demand related problems in various sectors of human activity. This book presents original research on various drought indicators, modern measurement techniques used, among others, for monitoring and predicting droughts, drought indicator trends, the impact of insufficient precipitation on human activity in the context of climate change, and examples of modern solutions devised to prevent water shortages.
    Keywords: extensive green roofs ; climate change ; summer drought ; urban vegetation ; phytomass ; fertilizer ; biodiversity ; blue green infrastructure ; pan evaporation ; ANN ; WANN ; SVM-RF ; SVM-LF ; Pusa station ; drought ; SPI ; run theory ; Sen’s estimator ; Mann–Kendall ; Wadi Cheliff Basin ; water stress ; soil moisture ; atmospheric evaporative demand ; eddy covariance ; gross primary productivity ; meteorological drought ; agricultural drought ; atmospheric circulation ; elementary circulation mechanism (ECM) ; information entropy ; atmospheric blocking ; hydrological drought ; trends ; central Poland ; lotic systems ; refuge habitats ; fish ; risk management ; forecasting ; ARIMA ; Standardized Precipitation Evapotranspiration Index (SPEI) ; mitigation ; atmospheric drought ; forest drought ; Carpathian Mts. ; beech ; vertical climate zones ; Copernicus Sentinel-1 ; electrical resistivity tomography ; expansive clay ; InSAR ; shrink-swell risk ; SMOS surface soil moisture ; wavelet analysis ; precipitation ; precipitation deficit ; climatic water balance ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: The constant search for innovative magnetic materials increasingly leads to the creation of highly engineered systems built in different forms (films, wires, particles), structured on the nanoscale in at least one spatial direction, and often characterized by the coexistence of two or more phases that are magnetically and/or structurally different. In magnetic systems, the nanometric structural characteristics of the constituent elements, together with the type and strength of the magnetic interactions between them, determine the overall magnetic behavior and can lead to the appearance of unexpected and amazing magnetic phenomena. Indeed, the study of the magnetic properties of nanomaterials continues to arouse great interest for their intriguing fundamental properties and prospective technological applications. This Special Issue contributes to broadening the knowledge on magnetic nanomaterials, demonstrating the breadth and richness of this research field as well as the growing need to address it through an interdisciplinary approach. The papers collected in this book (two reviews and eight regular articles) report cutting-edge studies on the production and characterization of a variety of novel magnetic nanomaterials (nanoparticles, nanocomposites, thin films and multilayers), which have the potential to play a key role in different technologically advanced sectors, such as biotechnology, nanomedicine, energy, spintronics, data storage, and sensors.
    Keywords: disordered magnetism ; super-spin glass ; glassy correlation length ; magnetic freezing ; nanogranular Au/Fe-oxide ; Fe-oxide nanocrystallites ; synthetic antiferromagnet ; exchange bias ; interlayer exchange coupling ; vibrating sample magnetometry ; CoFeB ; thermally assisted magnetic scanning probe lithography ; magnetron sputtering ; nanoparticles ; sol-gel ; Raman spectroscopy ; UV-blue photoluminescence ; ZnNiO ; Kubelka-Munk function ; Burstein-Moss shift ; substitutional doping ; FePd alloy ; electrodeposition technique ; magnetic properties ; structural characterisation ; ferrimagnetic materials ; superparamagnetism ; magnetic hysteresis ; magnetic materials ; magnetic nanoparticles ; nanocomposites ; nanowires ; martensitic transition ; Heusler alloys ; magnetic shape memory alloys ; twin boundary ; epitaxial Ni-Mn-Ga films ; transmission electron microscopy ; magnetic anisotropy ; iron nitrides ; III-nitrides ; nanocrystals ; density functional theory ; magnetic hyperthermia ; magneto-sonoporation ; stem cells ; superparamagnetic iron oxide particles ; cell labelling ; ultrasounds ; osteogenesis ; bone tissue engineering ; magnetic aggregates ; magnetic interactions ; core/shell nanoparticles ; multicore nanoparticles ; hybrid systems ; mixed nanoparticle systems ; chemical synthesis ; magnetic heating ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: People who have chronic diseases spend a significant amount of time in self-management in out-of-hospital environments, in their homes and in their community settings. These patients have different disease statuses and management requirements, so providing personalized care is key.Personalized care is a collaborative process that should be used in chronic condition management in which patients, caregivers, and healthcare providers identify and discuss problems caused by or related to the patient's condition and then develop plans and goals to empower patients.Personalized care can improve aspects of physical health, mental health, and the ability to self-manage conditions. Thus, a personalized care approach could greatly benefit patients with chronic conditions.In this book, we have included 20 articles that expand the current knowledge on the personalized care approach to diagnosing and treating chronically ill patients.
    Keywords: fibromyalgia ; physical functioning ; obesity ; pain catastrophizing ; pain acceptance ; chronic pain ; rehabilitation ; clinical psychology ; performance-based test ; dual-tasking ; cognitive function ; postural control ; older adults ; Parkinson disease ; personalized medicine ; clinical exercise ; exercise prescription ; boot camp ; physiotherapy ; compliance ; qualitative ; empowerment ; medication acceptability ; intentional nonadherence ; decision ; self esteem ; pharmacology ; rheumatology ; autoimmune ; adolescent ; nursing ; review literature ; sexuality ; virtual reality ; pain ; fatigue ; quality of life ; meta-analysis ; temporomandibular disorders ; surface electromyography ; aerobic exercise ; therapeutic exercise ; diabetes mellitus ; SGLT-2 inhibitors ; antidiabetic agents ; cardiovascular outcomes ; personalized therapy ; sleep ; chronic liver disease ; informal caregiver ; caregiver ; bibliometrics ; data analysis ; needs ; intervention ; patient-focused care ; aged ; disease prevention ; health promotion ; nursing education ; nursing students ; mental disorders ; mental illness ; social stigma ; students ; ageism ; stereotyping ; prejudice ; discrimination ; assessment ; aging ; stroke ; ischemia ; biomarkers ; mortality risk ; patient adherence ; glaucoma ; personalized care ; patient compliance ; child ; child abuse ; maltreatment ; neglect ; risk factors ; family ; caregivers ; child protective services ; advanced nursing practice ; rehabilitation nursing ; transitional care ; hospital discharge ; continuity of care ; hip fracture ; older person ; returning home ; safety ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: This Special Issue provides an overview of the applied experimental and numerical flow, models, which are used to investigate fluid flow in complex situations. The investigated problems are related to fundamental processes or new applications. As demonstrated, the field of the application of experimental and numerical flow models is constantly expanding.
    Keywords: subcooled flow boiling ; two-fluid model ; vapor volume fraction ; rod bundle ; STAR-CCM+ ; gas–liquid two-phase flow ; local flow parameters measurement ; four-sensor probe ; vector-based signal processing ; visual measurement experiment ; bearing chamber ; breakup ; coalescence ; population balance model ; two phase flow ; oil droplet size distribution ; computational fluid dynamics ; fluid-structure interaction ; flexible flaps ; bending line ; deformation ; mechanical chamber room ; performance enhancement ; flow channel ; cover back machine ; domestic refrigerator ; in-vitro experimental modeling ; CT-scanned OSAHS model ; oscillatory respiratory flow rates ; particle image velocimetry technique ; optical index matching ; inverted U-tube ; two-phase flow ; air/water vapor entrainment ; steam condenser ; solar energy ; parabolic trough collector ; thermal performance ; turbulator ; swirl generator ; numerical simulation ; LES ; microclimate model ; thermal radiation ; pollutant dispersion ; urban planning ; railway tunnel fire ; FDS ; tunnel ventilation ; tenability analysis ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: This book contains publications related to the special topic entitled: "The Latest Scientific Problems Related to the Implementation and Diagnostics of Construction Objects". Construction is a sector of the economy that is characterized by a very high variability of execution conditions and a large variety of building structures. In a period of very rapid economic development, this high variability and diversity generates many new scientific problems that must be solved in order to further improve the quality of production, as well as to reduce the cost and time of construction. The purpose of the issue is to present and discuss the results of the latest research in the broad field of construction engineering, particularly concerning: modification of the composition of construction materials using various micro- and nanomaterials, by-products or wastes; modern methods of controlling construction processes; methods of planning and effective management in construction, as well as methods of diagnosing construction objects. The articles published in this issue deal with theoretical, experimental, applied and modeling research conducted worldwide in the above-mentioned scientific areas.
    Keywords: reinforced concrete diagnostics ; non-destructive method ; galvanostatic pulse method ; reinforcement corrosion ; temperature impact ; FRP ; soft computing ; compressive strength ; confined concrete ; artificial neural network ; construction project management ; cost ; time ; Bank Investment Supervision ; self-compacting concrete ; cement matrix ; nanoparticles ; indentation ; creep ; buildings ; buildings elements ; rehabilitation needs ; rehabilitation planning ; degree of technical condition ; degradation of buildings ; the maximum aggregate grain size ; modulus of elasticity ; compressive and tensile strength of concrete ; aggregate crushing value ; gravel aggregate ; interfacial transition zone ; facade systems ; cost management ; structural analysis ; MICMAC method ; residential buildings ; warranty ; acceptance of the work ; health and safety ; workplace ; construction industry ; scaffoldings ; alcohol ; thin layer drying ; moisture ; drying rate ; sustainable development ; alfa fiber ; cement ; composite ; density ; mechanical properties ; thermal properties ; construction project ; random conditions ; online scheduling ; simulation method ; process mode selection ; deep excavation ; adjacent buildings ; HLC monitoring ; temporary support structure ; multicriteria decision-making ; retaining wall ; selection criteria ; construction requirements ; AHP method ; VIKOR method ; TOPSIS method ; contractor selection ; multi-criteria decision making ; decision support concept ; AHP ; PROMETHEE ; construction procurement ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: This Special Issue covers original and innovative basic research regarding the anti-inflammatory potential of several classes of secondary metabolites (i.e., polyphenols, phytosterols, proteoglycans, and polysaccharides) in manifestations of acute and chronic inflammation in both in vitro and in vivo experimental models.
    Keywords: laminarin ; aging ; transient cerebral ischemia ; neuroprotection ; oxidative stress ; neuroinflammation ; marine-derived fungi ; anti-inflammation ; anti-neuroinflammation ; PTP1B ; marine biocompounds ; neurodegeneration ; Alzheimer’s disease ; Parkinson’s disease ; Bacillus sp. ; proteoglycan ; macrophages ; Padina boryana ; RAW 264.7 macrophages ; Nrf2/HO-1 ; MAPK ; NF-κB ; P. oceanica ; inflammation ; pain ; CD-1 mice ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: Technology is changing the manufacturing world. For example, sensors are being used to track inventories from the manufacturing floor up to a retail shelf or a customer’s door. These types of interconnected systems have been called the fourth industrial revolution, also known as Industry 4.0, and are projected to lower manufacturing costs. As industry moves toward these integrated technologies and lower costs, engineers will need to connect these systems via the Internet of Things (IoT). These engineers will also need to design how these connected systems interact with humans. The focus of this Special Issue is the smart sensors used in these human–robot collaborations.
    Keywords: physical human-robot interaction ; game theory ; adaptive optimal control ; robot control ; tandem force sensor ; traction force sensor ; human–robot interaction ; contact task ; imitation learning ; safe physical human–robot collaboration ; collision detection ; human action recognition ; artificial intelligence ; industrial automation ; reinforcement learning ; social robotics ; human-robot interaction ; reward design ; physical embodiment ; human robot collaboration ; human robot interaction ; path planning ; bidirectional awareness ; haptic feedback device ; human machine interface ; collision identification ; collaborative robot ; deep learning ; uncertainty estimation ; knowledge distillation ; human–robot collaboration ; speed and separation monitoring ; human–machine differentiation ; thermal cameras ; protective separation distance ; collaborative robots ; motion planning ; human motion prediction ; human-following robots ; teleoperation ; high-speed image processing ; machine learning ; finger position recognition ; grasp type estimation ; human-robot collaboration ; human-centered robotics ; task planning ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This Special Issue of "Nanostructural Materials with Rare Earth Ions: Synthesis, Physicochemical Characterization, Modification and Applications" is related to studies of nanometer-sized materials doped and co-doped with rare earth ions and the creation of periodically ordered nanostructures based on single nanoparticles. A small particle size implies a high sensitivity and selectivity. These new effects and possibilities are mainly due to the quantum effects resulting from the increasing ratio of surface-to-volume atoms in low-dimensional systems. An important factor in this context is the design and fabrication of nanocomponents displaying new functionalities and characteristics for the improvement of existing materials, including photonic materials, conductive materials, polymers and biocomposites. With this concept in mind, the aim of the Special Issue is to publish research on innovative materials and their applications.Topics to be covered in this Special Issue include, but are not limited to, the following: Technology and applications of nanomaterials with rare earth ions; Advanced physicochemical properties, characterization and modification of nanomaterials with rare earth ions; Novel active materials, especially organic and inorganic materials, nanocrystalline materials, nanoceramics doped and co-doped with rare-earth ions with bio-related and emerging applications; Magnetic properties of nano-sized rare-earth compounds; Applications of nano-sized rare-earth-doped and co-doped optical materials.
    Keywords: calcium hydroxyapatite nanopowders ; rare earth ions ; poly(L-lactide) ; nanocomposites ; twin screw extrusion ; SmS ; EuS ; semiconductor-metal transition ; structural properties ; piezoresistivity ; interdiffusion ; rare earths ; thin films ; diphosphates ; up-conversion ; theranostics ; β-tricalcium diphosphate(V) ; Ce3+ and Pr3+ ions co-doping ; poly(l-lactide) ; stem cells ; nanomaterials ; bone augmentation ; nanohydroxyapatite ; Cu2+ ions ; ozonated olive oil ; hydroxyapatite ; antimicrobial activity ; microorganisms ; spectroscopy ; nanocrystallites ; silicate-substituted hydroxyapatite ; Eu3+ and Sr2+ ion co-doping ; microwave-assisted hydrothermal method ; lanthanides ; luminescence ; nitrogen-rich ligand ; phosphate sensing ; quenching ; dental nanomaterials ; dental implants ; endodontics ; prosthetic ; ozone ; orthodontics ; brackets ; wires ; antimicrobial effect ; apatite ; europium ions ; cooper ions ; photoluminescence spectroscopy ; EPR spectroscopy ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: This reprintshows recent advances in dam safety related to overtopping and the prevention, detection, and risk assessment of geostructural risks. Related to overtopping, the issues treated are: the throughflow and failure process of rockfill dams; the protection of embankment dams against overtopping by means of a rockfill toe or wedge-shaped blocks; and the protection of concrete dams with highly convergent chutes. In the area of geostructural threats, the detection of anomalies in dam behavior from monitoring data using a combination of machine learning techniques, the numerical modeling of seismic behavior of concrete dams, and the determination of the impact area downstream of ski-jump spillways are also studied and discussed. In relation to risk assessment, three chapters deal with the development of fragility curves for dikes and dams in relation to various failure mechanisms.
    Keywords: hydraulic structure ; sky-jump ; spillway ; flip bucket ; chute ; basin ; erosion ; flow rate ; jet flow ; wave overtopping ; levee ; cover ; probabilistic framework ; slope stability ; piping ; overtopping ; fragility curves ; Monte Carlo simulation ; dam ; stilling basin ; bucket ; flood ; weir ; safety ; protection ; dam protection ; wedge-shaped block ; WSB ; dam spillway ; dam safety ; ACUÑA ; rockfill dams ; throughflow ; numerical modeling ; non-Darcy flow ; porous media ; Forchheimer equation ; high velocity ; crushed rock ; rounded materials ; hydraulic mean radius ; intrinsic permeability ; shape of particles ; angularity of particles ; surface roughness of particles ; river levees ; geogrid reinforcement ; First Order Reliability Method (FORM) ; Surface Response Method (SRM) ; high gravity dams ; dam-foundation-reservoir dynamic interaction ; earthquake input mechanisms ; hydrodynamic pressure ; foundation size ; reservoir length ; stacking ; blending ; combination ; meta-learner ; experts ; machine learning ; Cross Validation ; radial displacement ; rockfill dam ; dam failure ; overflow ; floods ; dam breach ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: The gastrointestinal tract (GIT) can be broadly divided into several regions: the stomach, the small intestine (which is subdivided to duodenum, jejunum, and ileum), and the colon. The conditions and environment in each of these segments, and even within the segment, are dependent on many factors, e.g., the surrounding pH, fluid composition, transporters expression, metabolic enzymes activity, tight junction resistance, different morphology along the GIT, variable intestinal mucosal cell differentiation, changes in drug concentration (in cases of carrier-mediated transport), thickness and types of mucus, and resident microflora. Each of these variables, alone or in combination with others, can fundamentally alter the solubility/dissolution, the intestinal permeability, and the overall absorption of various drugs. This is the underlying mechanistic basis of regional-dependent intestinal drug absorption, which has led to many attempts to deliver drugs to specific regions throughout the GIT, aiming to optimize drug absorption, bioavailability, pharmacokinetics, and/or pharmacodynamics. In the book "Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation" we aim to highlight the current progress and to provide an overview of the latest developments in the field of regional-dependent intestinal drug absorption and delivery, as well as pointing out the unmet needs of the field.
    Keywords: bioequivalence ; Biopharmaceutics Classification System ; in vitro ; dissolution test ; pravastatin ; oral absorption ; in silico modeling ; GastroPlus ; Phoenix WinNonlin ; pharmacokinetics ; clinical studies ; ibuprofen ; manometry ; gastrointestinal ; mechanistic modeling ; PBPK ; PBBM ; disintegration ; dissolution ; enteric-coated ; ICH ; quality control ; regional intestinal permeability ; permeation enhancers ; absorption-modifying excipients ; oral peptide delivery ; intestinal perfusion ; pharmaceutical development ; controlled release drug product ; biopharmaceutics classification system ; drug solubility ; drug permeability ; location-dependent absorption ; segregated flow intestinal model (SFM) ; traditional model (TM) ; route-dependent intestinal metabolism ; first-pass effect ; drug-drug interactions ; DDI ; in vitro in vivo extrapolations ; IVIVE ; zero-order absorption ; first-order absorption ; combined zero- and first-order absorption ; transit compartment absorption model ; in situ perfusion ; microdevices ; shape ; mucoadhesion ; colon absorption ; nutrient digestion ; nutrient absorption ; gastrointestinal hormone ; postprandial glycaemia ; energy intake ; region of the gut ; obesity ; type 2 diabetes ; Franz–PAMPA ; BCS drugs ; biomimetic membrane ; Franz cell ; passive drug transport ; BCS class IV drugs ; segmental-dependent intestinal permeability ; intestinal absorption ; oral drug delivery ; biopharmaceutics ; physiologically-based pharmacokinetic (PBPK) modeling ; furosemide ; intestinal permeability ; human colon carcinoma cell layer (Caco-2) ; hierarchical support vector regression (HSVR) ; drug absorption ; drug solubility/dissolution ; regional/segmental-dependent permeability and absorption ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-24
    Description: Nowhere is the explosion in comprehensive genomic testing more evident than in oncology. Multiple consensus guidelines now recommend molecular testing as the standard of care for most metastatic tumors. To aid in the advancement of this rapidly changing field, we intend this Special Issue of JPM to focus on technical developments in the genomic profiling of cancer, detail promising somatic alterations that either are, or have a high likelihood of being, relevant in the near future, and to address issues related to the pricing and value of these tests.The last few years have seen the cost of molecular testing decrease by orders of magnitude. In 2018, we saw the first “site-agnostic” drug approvals in cancer (for microsatellite unstable cancer (PD-1 inhibitors) and NTRK-fusions (TRK inhibitors)). Research on targetable mutations, determination of genetic “signatures” that can use multiple individual genes/pathways, development of targeted therapy, and insight into the value of new technology remains at the cutting edge of research in this field. We are soliciting papers that present new technologies to assess predictive biomarkers in cancer, original research (pre-clinical or clinical) that demonstrates promise for particular targeted therapies in cancer, and articles that explore the clinical and financial impacts of this paradigmatic shift in cancer diagnostics and treatment.
    Keywords: patient-derived tumor xenograft (PDX) ; anti-cancer drug development ; immunodeficient mice ; precision medicine ; molecular profiling ; immunohistochemistry ; next-generation sequencing ; targeted therapy ; molecular oncology ; biomarkers ; molecular imaging ; non-small cell lung cancer ; proliferation ; cancer stem cells ; circulating tumour cells ; personalised treatment ; renal cell carcinoma ; clear cell ; VEGF ; immunotherapy ; PD-L1 ; immune checkpoint inhibitors ; immune checkpoint blockade ; tyrosine-kinase inhibitors ; integrin-linked kinase (ILK) ; ovarian cancer ; sgRNA ; gene expression ; microarray ; xenograft ; MTB ; cancer ; oncology practice ; community setting ; CGP ; pancreatic cancer ; FOLFIRINOX ; chemotherapy ; gender ; cholangiocarcinoma ; biliary tract cancer ; prognosis ; neutrophils ; BRCA1 ; BRCA2 ; PALB2 ; homologous recombination repair ; colorectal cancer ; heme oxygenase-1 ; endothelin-1 ; endothelin con-verting enzyme-1 ; bosentan ; precision oncology ; tumor-agnostic indications ; solid tumors ; tumor markers ; FDA-approved therapeutics ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This Special Issue consists of selected papers from the Experimental Stress Analysis 2020 conference. Experimental Stress Analysis 2020 was organized with the support of the Czech Society for Mechanics, Expert Group of Experimental Mechanics, and was, for this particular year, held online in 19–22 October 2020. The objectives of the conference included identification of current situation, sharing professional experience and knowledge, discussing new theoretical and practical findings, and the establishment and strengthening of relationships between universities, companies, and scientists from the field of experimental mechanics in mechanical and civil engineering. The topics of the conference were focused on experimental research on materials and structures subjected to mechanical, thermal–mechanical, and dynamic loading, including damage, fatigue, and fracture analyses. The selected papers deal with top-level contemporary phenomena, such as modern durable materials, numerical modeling and simulations, and innovative non-destructive materials’ testing.
    Keywords: residual stresses ; neutron diffraction ; three axis setting ; high resolution ; bent crystal monochromator ; bent crystal analyzer ; stainless steel 316L ; additive manufacturing ; multiaxial loading ; plasticity ; digital image correlation method ; hill yield criterion ; isotropic hardening ; finite element method (FEM) ; straightening process ; three-point bending ; FEM ; control strategy ; billet straightening ; multiaxial fatigue ; high-cycle fatigue ; multiaxial fatigue experiments ; S-N curve approximation ; laser welding ; pressure vessel steel ; microstructure ; X-ray and neutron diffraction ; high-cycle fatigue tests ; wearable ; flexible ; structure ; stiffness ; biomedical ; mechanics ; simulation ; pattern ; 3D print ; PA12 ; tram ; pedestrian ; crash ; windshield model ; HIC ; hole-drilling ; PhotoStress ; digital image correlation ; experimental analysis ; finite element analysis ; composite ; thermoplastic ; interlaminar strength ; polyphenylensulfid ; polyetheretherketone ; polyaryletherketone ; curved beam ; NDE ; infrared thermography ; Infrared Nondestructive Testing ; CFRP ; Anand material model ; material parameters ; ABS-M30 ; indentation test ; genetic algorithm ; acoustic emission ; CFRP composite tube ; unsupervised learning approach ; failure mechanism ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: The first national conference with international participation, “Fundamental aspects of atherosclerosis: scientific research for improving the technologies of personalized medicine”, was held in Novosibirsk on 15 October, 2021. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of atherosclerosis among various relevant specialists. The conference was intended for practicing cardiologists, primary care physicians, medical geneticists, and physician–scientists. The conference included plenary sessions, specialty sessions, satellite symposia, an open competition for young scientists.
    Keywords: metalloproteinases ; calcification ; atherosclerosis ; multiplex assay ; coronary heart disease ; aspirin ; resistance ; non-sensitivity ; antiplatelet ; light transmission aggregometry ; Plateletworks® ; familial hypercholesterolemia ; targeted sequencing technologies ; multiplex ligation-dependent probe amplification ; LDLR ; APOB ; ABCG5 ; APOC3 ; LPL ; SREBF1 ; rare variants ; coronary atherosclerosis ; ischemic heart disease ; saturated fatty acids ; monounsaturated fatty acids ; polyunsaturated fatty acids ; oxidative stress ; superoxide dismutase ; catalase ; glutathione peroxidase ; cumulative LDL-C level ; prognosis ; DNA methylation ; epigenetic age ; myocardial infarction ; acute coronary syndrome ; population ; nested case-control ; HAPIEE project ; HAPIEE study ; atrial fibrillation ; arterial hypertension ; obesity ; diabetes mellitus ; aging ; determinants ; prevalence ; Russian population cohort ; Cox regression analysis ; adiponectin ; leptin ; interleukin-6 ; epicardial adipose tissue ; perivascular adipose tissue ; circulating biochemical markers ; coronary atherosclerosis presence and severity ; integrated biomarker (i-BIO) ; validation ; visual markers ; lipoprotein(a) ; immune cells blood count ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Due to the ongoing rise in sea level and increases in extreme wave climates, which consequently change the wave climate, coastal structures such as sea dikes and seawalls are exposed to severe and frequent sea storms. Even though much research related to wave–structure interactions has been carried out, it remains one of the most important and challenging topics in the field of coastal engineering. The recent publications in the Special Issue “Wave Interactions with Coastal Structures” in the Journal of Marine Science and Engineering include a wide range of research, including theoretical/mathematical, experimental, and numerical work related to the interaction between sea waves and coastal structures. These publications address conventional coastal hard structures in deep water zones as well as those located in shallow water zones, such as wave overtopping over shallow foreshores with apartment buildings on dikes. The research findings presented help to improve our knowledge of hydrodynamic processes, and the new approaches and developments presented here will be good benchmarks for future work.
    Keywords: shallow waters ; wave energy ; coastal erosion ; beach restoration ; submerged breakwaters ; protected nourishments ; wave overtopping ; coastal safety ; flow velocity ; flow depth ; sea dikes ; overtopping reduction ; force reduction ; oblique waves ; storm return wall ; EurOtop manual ; validation ; wave modelling ; shallow foreshore ; dike-mounted vertical wall ; wave impact loads ; OpenFOAM ; average overtopping discharge ; individual volume ; overtopping flow depth ; overtopping flow velocity ; promenade ; vertical wall ; SWASH ; fluid–structure interaction ; waves ; smoothed particle hydrodynamics ; SPH ; Pont del Petroli ; storm Gloria ; inter-model comparison ; DualSPHysics ; wave pressure ; caisson breakwater ; stability ; RANS model ; solitary wave ; fully nonlinear wave ; three-dimensional wave ; partially submerged cylinder ; hollow circular cylinder ; tsunami ; wave ; bore ; flooding ; debris ; numerical modeling ; SPH–FEM coupling ; coastal structures ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-10-25
    Description: In recent years, improving the sustainability of the steel industry and reducing its CO2 emissions has become a global focus. To achieve this goal, further process optimization in terms of energy and resource efficiency and the development of new processes and process routes are necessary. Modeling and simulation have established themselves as invaluable sources of information for otherwise unknown process parameters and as an alternative to plant trials that involves lower costs, risks, and time. Models also open up new possibilities for model-based control of metallurgical processes. This Special Issue focuses on recent advances in the modeling and simulation of unit processes in iron and steelmaking. It includes reviews on the fundamentals of modeling and simulation of metallurgical processes, as well as contributions from the areas of iron reduction/ironmaking, steelmaking via the primary and secondary route, and continuous casting.
    Keywords: liquid metals ; bubble generation ; bubble size distribution ; porous plugs ; bubble deformation ; drag force ; lift force ; mathematical modelling ; computational fluid dynamic ; slag heat recovery ; heat exchanger ; drying ; slag energy content ; heat recovery technology ; RecHeat ; rotary kiln ; reduction process ; numerical simulation ; pre-reduction ; scrap preheating ; electric arc furnace ; continuous charging ; turbulence modelling ; RANS/LES/DNS ; inflow condition ; model validation ; model application ; energy demand ; regression ; artificial neural network ; Gaussian process regression ; Köhle formula ; evaluation model ; quantitative relationship ; scrap melting ; mass transfer coefficient ; steelmaking process ; direct current ; arc impingement ; arc gap ; gas density ; electric arc ; magneto hydrodynamics ; computational fluid dynamics ; real-time model ; estimation ; model predictive control ; steel refining ; mathematical modeling ; carbon composite briquette ; blast furnace ironmaking ; reaction kinetics ; coke saving ; direct reduction ; Midrex ; HYL ; Rist diagram ; energy consumption ; profile optimization ; modelling ; machine learning ; steelmaking ; fuzzy modelling ; evolving modelling ; continuous casting ; near net shape casting ; twin roll (Bessemer) casting ; horizontal single belt casting ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This Special Issue book covers a wide scope in the research field of 3D-printing, including: the use of 3D printing in system design; AM with binding jetting; powder manufacturing technologies in 3D printing; fatigue performance of additively manufactured metals, such as the Ti-6Al-4V alloy; 3D-printing methods with metallic powder and a laser-based 3D printer; 3D-printed custom-made implants; laser-directed energy deposition (LDED) process of TiC-TMC coatings; Wire Arc Additive Manufacturing; cranial implant fabrication without supports in electron beam melting (EBM) additive manufacturing; the influence of material properties and characteristics in laser powder bed fusion; Design For Additive Manufacturing (DFAM); porosity evaluation of additively manufactured parts; fabrication of coatings by laser additive manufacturing; laser powder bed fusion additive manufacturing; plasma metal deposition (PMD); as-metal-arc (GMA) additive manufacturing process; and spreading process maps for powder-bed additive manufacturing derived from physics model-based machine learning.
    Keywords: powder-bed additive manufacturing (AM) ; powder spreading ; spreading process map ; discrete element method (DEM) ; machine learning ; GMA additive manufacturing ; weld reinforcement ; visual features ; neural network ; selective laser melting ; magnesium alloys ; properties ; plasma metal deposition ; additive manufacturing ; 316L ; processing conditions ; mechanical properties ; microstructure ; virgin ; recycled ; metal powders ; laser powder bed fusion ; laser additive manufacturing ; 316l ss ; nickel alloy ; tribological behavior ; porosity ; rough surface ; ultrasonic testing ; convolutional neural network ; deep neural network ; multi-layer perceptron ; key performance indicators ; topology optimization ; design for additive manufacturing ; design for additive manufacturing services ; selective laser melting (SLM) ; laser powder bed fusion (LPBF) ; powder ; particle size distribution ; particle morphology ; powder layer density ; part density ; flowability ; Hausner ratio ; electron beam melting ; customized implant ; cost analysis ; fitting accuracy ; cranial reconstruction ; thin wall manufacturing ; process modelling ; ultrasonic vibration ; laser directed energy deposition ; coating ; TiC-TMC ; extremity ; revision ; limb salvage surgery ; 3D printing ; customized ; implant ; powder metallurgy ; simulated body fluid ; biomaterial ; fatigue ; titanium ; direct laser deposition ; Inconel 625 ; parametrisation ; microhardness ; preheating ; binder jetting ; sand casting ; aluminum alloy ; corrosion ; pressure drop ; heat exchanger ; surface textures ; dimples ; drag reduction ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: This book reprints articles from the Special Issue "Industrial Applications: New Solutions for the New Age" published online in the open-access journal Machines (ISSN 2075-1702). This book consists of twelve published articles. This special edition belongs to the "Mechatronic and Intelligent Machines" section.
    Keywords: induction machines ; electrical machines ; vector control ; SVPWM modulation ; frequency inverter ; artificial intelligence ; photovoltaics ; fault detection ; machine learning ; operation and maintenance ; renewable energy ; water-in-crude oil emulsion ; water content ; ultrasound ; propagation velocity ; exoskeletons ; test bench ; industry ; benchmarking ; microgrid model-based systems engineering ; service systems ; goal-oriented requirements engineering ; safety instrumented system ; ventricular assist device Bayesian network ; Petri net ; control strategy ; UAV ; fuzzy ; PID controller ; ROS ; Industry 4.0 ; database ; data models ; big data and analytics ; asset administration shell ; MLOps ; digital twin ; IoT ; prediction ; coordinate metrology ; optical scanning ; noise reduction ; digital manufacturing ; integrated inspection system ; data analytics ; uncertainty ; convolutional neural networks ; warehouse management ; image classification ; ensemble learning ; synthetic data ; depth image ; electrical maintenance ; COVID-19 ; thermography ; fever ; computer vision ; intelligent systems ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: The impact of buildings on the environment is nothing short of devastating. In recent years, much attention has been given to creating an environmentally friendly built environment. Nonetheless, it has been levied on new buildings. Residential buildings make up at least 80% of the built environment, most of which were built before any energy efficiency guidelines or regulations were introduced. Retrofitting existing residential buildings is a key yet neglected priority in effecting the transition to an environmentally friendly, sustainable built environment. It is pivotal to reducing a building’s energy consumption while simultaneously improving indoor environmental quality and minimizing harmful emissions. This Special Issue showcases studies investigating applications of environmental technology that is tailored to enhance the sustainable performance of existing residential buildings. It helps to better understand the innovations that have been taking place in retrofitting residential buildings, as well as highlighting many opportunities for future research in this field.
    Keywords: automatically generated heating ventilating and air conditioning (HVAC) controllers ; Building Information Modelling (BIM) ; Industry Foundation Classes (IFC) ; advanced building controls ; HVAC control ; occupancy prediction ; energy consumption ; thermal comfort ; smart building ; smart city ; Bayesian networks ; elevator control algorithm ; intelligent elevator system ; decision theory ; decision support systems ; solar PV ; battery ; costs ; CO2 emissions ; electric vehicle ; high-density residential district ; pedestrian wind environment ; computational fluid dynamics ; enclosure boundary ; lift-up design ; bushfire ; retrofit ; ember attack ; pressure differential ; urban fringe ; rural housing ; pyro-tornadogenesis ; backdraft ; self-consumption ; solar photovoltaics ; heat pumps ; thermal storage ; space heating ; space cooling ; residential construction ; retrofitting ; sustainable construction ; literature review ; research trends ; scientometric review ; carbon emission ; Green Building-Rating System (GBS) ; cross laminated timber (CLT) ; hybrid structure system ; radiant system ; conditioning system ; residential building ; BIM ; IFC ; architecture model enrichment ; machine learning ; IfcSpace ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: Nowadays, we are witnessing highly dynamic research activities related to the intriguing field of biodegradable materials with plastic-like properties. These activities are currently intensified by a strengthened public awareness of prevailing ecological issues connected to growing piles of plastic waste, microplastic formation, and increasing greenhouse gas emissions; this goes hand-in-hand with the ongoing depletion of fossil feedstocks, which are traditionally used to produce full carbon backbone polymers. To a steadily increasing extend, polyhydroxyalkanoate (PHA) biopolyesters, a family of plastic-like materials with versatile material properties, are considered a future-oriented solution for diminishing these concerns. PHA production is based on renewable resources, and occurs in a bio-mediated fashion by the action of living organisms. If accomplished in an optimized way, PHA production and the entire PHA lifecycle are embedded into nature´s closed cycles of carbon. Holistic improvement of PHA production, applicable on an industrially relevant scale, calls for inter alia: consolidated knowledge about the enzymatic and genetic particularities of PHA accumulating organisms, in-depth understanding of the kinetics of the bioprocess, the selection of appropriate inexpensive fermentation feedstocks, tailoring the composition of PHA on the level of the monomeric constituents, optimized biotechnological engineering, and novel strategies for PHA recovery from biomass characterized by minor energy and chemical requirement.
    Keywords: polyhydroxyalkanoate ; PHOU ; water soluble PHA ; network ; tannic acid ; polyhydroxyalkanoates ; PHB ; PAT ; Synechocystis sp. PCC 6714 ; process monitoring ; ultrasound particle manipulation ; Tepidimonas taiwanensis ; grape pomace ; thermophiles ; cheese whey ; acetic acid ; Acetobacter pasteurianus C1 ; Bacillus sp. CYR-1 ; PHA ; biodegradable plastic ; PHBHHx ; CO2 ; Cupriavidus necator ; hydrogen-oxidizing bacterium ; biopolymers ; commercialization ; copolyester ; homopolyester ; polyhydroxybutyrate ; biopolymer ; plasticizer ; ferulic acid ; poly(3-hydroxybutyrate) ; cell retention ; volatile fatty acids ; Bacillus megaterium ; polyhydroxyalkanoates (PHA) ; polyhydroxybutyrate (PHB) ; mixed microbial cultures ; activated sludge ; respiration kinetics ; Monod kinetics ; oxygen mass balance ; hysteresis ; process modelling ; sugar beet molasses ; hydrolysis ; synthesis ; properties of PHA ; cyanobacteria ; habitat conditions ; sampling ; wild types ; single species selection ; purification ; axenic cultures ; growth ; non-phototrophic CO2 assimilation ; Knallgas cultivation ; Chemolithotrophs ; ATEX compliant bioreactor ; dissolved oxygen control ; mcl-PHAs ; scl-PHAs ; polythioester ; 3-hydroxybutyrate ; bioplastic ; alpha-methylated ; rubber-like elasticity ; polyhydroxyalkanoate (PHA) ; poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (P(HB-co-HV)) ; mixed microbial culture (MMC) ; hypochlorite digestion ; subcritical water (SBW) ; autotrophs ; biopolyesters ; industrialization ; mcl-PHA ; polymer processing ; polymer recovery ; process design ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-11-17
    Description: Today’s power system is facing the challenges of increasing global demand for electricity, high-reliability requirements, the need for clean energy and environmental protection, and planning restrictions. To move towards a green and smart electric power system, centralized generation facilities are being transformed into smaller and more distributed ones. As a result, the microgrid concept is emerging, where a microgrid can operate as a single controllable system and can be viewed as a group of distributed energy loads and resources, which can include many renewable energy sources and energy storage systems. The energy management of a large number of distributed energy resources is required for the reliable operation of the microgrid. Microgrids and nanogrids can allow for better integration of distributed energy storage capacity and renewable energy sources into the power grid, therefore increasing its efficiency and resilience to natural and technical disruptive events. Microgrid networking with optimal energy management will lead to a sort of smart grid with numerous benefits such as reduced cost and enhanced reliability and resiliency. They include small-scale renewable energy harvesters and fixed energy storage units typically installed in commercial and residential buildings. In this challenging context, the objective of this book is to address and disseminate state-of-the-art research and development results on the implementation, planning, and operation of microgrids/nanogrids, where energy management is one of the core issues.
    Keywords: energy demand ; long-term forecasting ; machine learning ; R programming ; solar power generation ; support vector regression ; economic energy ; Bonobo Optimizer ; hybrid renewable energy system ; microgrid ; PV panels ; wind turbine ; energy storage ; hierarchical control ; primary ; secondary control ; droop control ; frequency restoration ; voltage restoration ; grid synchronization ; proportional resonant controller ; robust control ; distributed generation, microgrid ; LMI ; optimization ; lightning attachment procedure optimization (LAPO) algorithm ; photovoltaic panel ; uncertainty ; cooperation ; energy ; reliability ; Monte Carlo ; smart energy control ; grid-synchronization ; dynamic voltage restorer ; converter control system ; sliding mode control ; economic scheduling ; clean energy ; quantum mayfly algorithm (QMA) ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Dear Readers, Oncolytic Viruses (OV) are self-propagating agents that can selectively induce the lysis of cancer cells while sparing normal tissues. OV-mediated cancer cell death is often immunogenic and triggers robust anticancer immune responses and immunoconversion of tumor microenvironments. This makes oncolytic virotherapy a promising new form of immunotherapy and OVs ideal candidates for combination therapy with other anticancer agents, including other immunotherapeutics. There are more than 40 OVs from nine different families in clinical development and many more at the preclinical stage. Each OV has its own unique characteristics, its pros and cons. Although herpes simplex virus is currently the lead clinical agent, a real champion among the OVs has not yet emerged, justifying the continuous development and optimization of these agents. This book, “Oncolytic Virus Immunotherapy”, summarizes the state-of-the-art and gives a comprehensive overview of the OV arena with a particular focus on new trends, directions, challenges, and opportunities.
    Keywords: oncolytic viruses ; melanoma ; immunotherapy ; checkpoint inhibitors ; combinatory therapy ; reovirus ; oncolytic virus ; adenovirus ; oncolytic ; virotherapy ; targeting ; immunogenic cell death ; αvβ6 integrin ; oncolytic adenovirus ; cancer immunotherapy ; multi-stage ; immunostimulatory ; arming ; HSV-1 ; clinical trials ; newcastle disease virus ; NDV ; cancer ; immune checkpoint inhibitor ; PD-1 ; PD-L1 ; CTLA-4 ; type I interferon ; herpes simplex virus ; retargeted virus ; tropism retargeting ; tumor ; checkpoint inhibitor ; vaccination ; antigen-agnostic vaccination ; HER2 ; parvovirus ; tumor microenvironment ; combination therapy ; glioblastoma ; pancreatic cancer ; colorectal cancer ; measles virus ; vector engineering ; immune checkpoint blockade ; antitumor immune response ; delivery ; genetic modification ; biomarkers ; personalized oncolyticvirotherapy ; class I HLA ; immunosurveillance ; immunoediting ; oncogenic signaling ; RAS ; DNA methyltransferase inhibitor (DNMTi) ; viral mimicry ; epigenetic silencing ; adoptive T cell therapy ; CAR T cell ; pancreatic ductal adenocarcinoma ; vesicular stomatitis virus ; small molecule ; cancer immune therapy ; cancer therapy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: This Special Issue of Cancers focuses on new advances in the treatment of renal cell carcinoma, both surgical and pharmacological (and combinations of these), and novel approaches to tackle treatment resistance and improve our understanding of this phenomenon.
    Keywords: renal cell carcinoma ; autophagy ; hydroxychloroquine ; chloroquine ; ROC-325 ; cysteine cathepsins ; cysteine cathepsin inhibitors ; lysosome ; renal cancer ; metastatic renal cell carcinoma ; immune-based combination therapies ; network meta-analysis ; PD-L1 ; predictive ; biomarker ; treatment ; TKIs ; mRCC ; biomarkers ; soluble factors ; immunotherapy ; renal cell carcinoma (RCC) ; sunitib resistance ; artesunate (ART) ; Traditional Chinese Medicine (TCM) ; growth inhibition ; ferroptosis ; reactive oxygen species (ROS) ; clear cell renal cell carcinoma ; ccRCC ; RCC ; kidney cancer ; evolution ; evolutionary trajectory ; metastatic ; second line therapy ; renal cell cancer ; immune checkpoint inhibitors ; tyrosine kinase inhibitors ; individualization ; genomic signature ; transcriptomic analysis ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-08-12
    Description: For many years, the trend of increasing energy demand has been visible. Despite the search for alternative energy sources, it is estimated that oil and natural gas will be the main source of energy in transport for the next several dozen years. However, the reserves of renewable raw materials are limited in volume. Along with the degree of depletion, oil recovery becomes more and more difficult, even though the deposits are not yet completely empty. Therefore, it is essential to find new methods to increase oil and gas recovery. Actions aimed at intensifying oil recovery are very rational use of energy that has not yet been fully used. Usually, an increase in oil recovery can be achieved by using extraction intensification methods. However, measures to increase oil recovery can be implemented and carried out at any stage of the borehole implementation. Starting from the well design stage, through drilling and ending with the exploitation of oil and gas. Therefore, in order to further disseminate technologies and methods related to increasing oil recovery, a special edition has been developed, entitled "Fundamentals of Enhanced Oil Recovery". This Special Issue mainly covers original research and studies on the above-mentioned topics, including, but not limited to, improving the efficiency of oil recovery, improving the correct selection of drilling fluids, secondary methods of intensifying production and appropriate energy management in the oil industry.
    Keywords: gas migration ; well cementing ; cement slurry ; cement sheath ; corrosion resistance ; gas outflows ; oil-based mud ; invert drilling fluid ; water phase ; oil phase ; emulsion stability ; emulsifier ; drilling mud ; oxidants ; enzymes ; filter cake ; improving the sealing of the borehole ; rational selection of drilling fluids ; cleaning the borehole ; adhesion ; spacer fluid ; CO2 and H2S geological sequestration ; acid gas reinjection ; acid gas migration ; bottomhole sampling ; isotopic composition ; gas and water chemical analysis ; soil gas analysis ; leakage risk analysis ; improved borehole sealing ; nanosilica ; cement stone ; mechanical parameters ; drilling fluids ; wash ; mud cake ; annular space ; borehole cleaning ; cementing ; wash contact time ; high temperature on corrosion of mining pipes ; water ; aggressive natural gas components ; L80-1 steel ; water shut-off treatment ; gas production ; water-gas ratio (WGR) ; formation permeability ; well logging data quality and quantity interpretation ; gas well ranking ; water flooding ; pore scale ; enhanced oil recovery ; viscosity ; capillarity ; jet pump ; oil ; well ; sucker-rod pump ; gas-water-oil mixture ; chrome coating ; unconventional resources ; shale gas ; oil gas ; total organic carbon (TOC) ; cluster analysis ; genetic type of kerogen ; WAG ; carbonate reservoir ; CO2 ; acid gas ; high-nitrogen natural gas ; water alternating gas ; EOR ; recovery factor ; genetic programming ; fine-grained material ; borehole sealing efficiency ; technological parameters ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-24
    Description: The first all-Russia conference with international participation “Basic Research in Endocrinology: A Modern Strategy for the Development and Technologies of Personalized Medicine” was held in Novosibirsk on 26–27 November 2020. The purpose of this conference was to disseminate the latest basic and clinical findings in the fields of etiology, clinical characteristics, and modern diagnostics and treatments of endocrine disorders among various relevant specialists. The conference was intended for practicing endocrinologists, primary care physicians, medical geneticists, pediatric endocrinologists, pediatricians, and physician–scientists. The main topics included epidemiology and pathogenesis of endocrine disorders; genomic research in endocrinology; biochemical characteristics of endocrine aberrations; immunology and immunogenetics in endocrinology; cellular technologies in endocrinology; metabolomic research in endocrinology; pharmacogenetics; basic pathomorphology; high-tech care of patients with endocrine disorders; iodine-deficiency-related, autoimmune, and oncological diseases of the thyroid; modern diagnostic and therapeutic strategies for diabetes mellitus; osteoporosis and osteopenias; polyendocrinopathies; an interdisciplinary approach to the diagnosis and treatment of obesity and metabolic syndrome; hypo- and hyperparathyroidism, vitamin D; neuroendocrine disorders; reproductive health; rehabilitation of patients with endocrine disorders; health resort and spa treatments of endocrine disorders and comorbid conditions.
    Keywords: diagnostic method ; severity of disturbances ; rheology ; diabetes mellitus ; erythrocyte ; dielectrophoresis ; anemia of chronic disease ; iron deficiency anemia ; hyperlipidemia ; inflammation ; C-reactive protein ; tumor necrosis factor-α ; erythrocyte sedimentation rate ; osteoporosis ; fracture ; menopause ; population ; chronic non-communicable diseases ; risk factors ; early IHD ; abdominal obesity ; blood cytokines/chemokines complex ; multiplex assay ; Flt3 ligand ; GM-CSF ; MCP-1 ; IL-4 ; maturity onset diabetes of the young type 14 ; APPL1 ; single-nucleotide variant ; Firmicutes ; Bacteroidetes ; gut microbiota ; bile microbiota ; gallstone patients ; maturity onset diabetes of the young ; MODY ; multiplex ligation-dependent probe amplification ; next-generation sequencing ; GCK ; HNF1A ; HNF4A ; HNF1B ; obesity ; BMI ; blood tests ; proteomics ; mass spectrometry ; norepinephrine concentration in the hypothalamus ; heart mass ; QTL analysis ; SNPs ; ISIAH hypertensive rat strain ; risk factor ; diabetes risk scale ; diabetes risk model ; type 1 diabetes mellitus ; type 2 diabetes mellitus ; proton spectroscopy ; hippocampus ; cognitive dysfunction ; n/a ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: The electrical energy industry is undergoing dramatic changes: massive deployment of renewables, increasing share of DC networks at transmission and distribution levels, and at the same time, a continuing reduction in conventional synchronous generation, all contribute to a situation where a variety of technical and economic challenges emerge. As the society’s reliance on electrical power continues to increase as a result of international decarbonisation commitments, the need for secure and uninterrupted delivery of electrical energy to all customers has never been greater. Power system protection plays an important enabling role in future decarbonized energy systems. This book includes ten papers covering a wide range of topics related to protection system problems and solutions, such as adaptive protection, protection of HVDC and LVDC systems, unconventional or enhanced protection methods, protection of superconducting transmission cables, and high voltage lightning protection. This volume has been edited by Adam Dyśko, Senior Lecturer at the University of Strathclyde, UK, and Dimitrios Tzelepis, Research Fellow at the University of Strathclyde.
    Keywords: decentralized protection scheme ; fault analysis ; low voltage direct current grids ; plug-and-play systems ; solid-state circuit breakers ; DC grids ; fault protection ; local detection ; local action ; DC circuit breaker ; AC microgrid ; adaptive protection ; IEC 61850 GOOSE protocol ; substation automation ; adaptive auto-reclosing ; power system protection ; EV transmission lines ; transient fault ; Hilbert–Huang transform ; microgrid ; distributed generation ; inverse-time over-current protection ; coordination optimization ; superconducting cable ; quench ; high temperature ; coppers stabilizer ; superconducting tape ; fault current limiting feature ; power generation-side ; multi-information fusion ; hierarchical protection system ; system layer ; station layer ; local layer ; wavelet entropy ; transient component ; MMC-HVDC ; protection ; building integrated photovoltaic (BIPV) ; lightning attachment characteristics ; lightning energy withstand capability ; numerical and experimental analysis ; ±230 kV MMC-HVDC ; zero-crossing DCCB ; DC transmission line ; fault current ; hybrid DCCB ; bidirectional DCCB ; external elements ; energy dissipation ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Evolutionary algorithms (EAs) are population-based global optimizers, which, due to their characteristics, have allowed us to solve, in a straightforward way, many real world optimization problems in the last three decades, particularly in engineering fields. Their main advantages are the following: they do not require any requisite to the objective/fitness evaluation function (continuity, derivability, convexity, etc.); they are not limited by the appearance of discrete and/or mixed variables or by the requirement of uncertainty quantification in the search. Moreover, they can deal with more than one objective function simultaneously through the use of evolutionary multi-objective optimization algorithms. This set of advantages, and the continuously increased computing capability of modern computers, has enhanced their application in research and industry. From the application point of view, in this Special Issue, all engineering fields are welcomed, such as aerospace and aeronautical, biomedical, civil, chemical and materials science, electronic and telecommunications, energy and electrical, manufacturing, logistics and transportation, mechanical, naval architecture, reliability, robotics, structural, etc. Within the EA field, the integration of innovative and improvement aspects in the algorithms for solving real world engineering design problems, in the abovementioned application fields, are welcomed and encouraged, such as the following: parallel EAs, surrogate modelling, hybridization with other optimization techniques, multi-objective and many-objective optimization, etc.
    Keywords: Automatic Voltage Regulation system ; Chaotic optimization ; Fractional Order Proportional-Integral-Derivative controller ; Yellow Saddle Goatfish Algorithm ; two-stage method ; mono and multi-objective optimization ; multi-objective optimization ; optimal design ; Gough–Stewart ; parallel manipulator ; performance metrics ; diversity control ; genetic algorithm ; bankruptcy problem ; classification ; T-junctions ; neural networks ; finite elements analysis ; surrogate ; beam improvements ; beam T-junctions models ; artificial neural networks (ANN) limited training data ; multi-objective decision-making ; Pareto front ; preference in multi-objective optimization ; aeroacoustics ; trailing-edge noise ; global optimization ; evolutionary algorithms ; nearly optimal solutions ; archiving strategy ; evolutionary algorithm ; non-linear parametric identification ; multi-objective evolutionary algorithms ; availability ; design ; preventive maintenance scheduling ; encoding ; accuracy levels ; plastics thermoforming ; sheet thickness distribution ; evolutionary optimization ; genetic programming ; control ; differential evolution ; reusable launch vehicle ; quality control ; roughness measurement ; machine vision ; machine learning ; parameter optimization ; distance-based ; mutation-selection ; real application ; experimental study ; global optimisation ; worst-case scenario ; robust ; min-max optimization ; optimal control ; multi-objective optimisation ; robust design ; trajectory optimisation ; uncertainty quantification ; unscented transformation ; spaceplanes ; space systems ; launchers ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-03-21
    Description: Environmental odour is perceived as a major nuisance by rural as well as urban populations. The sources of odourous substances are manifold. In urban areas, these include restaurants, small manufacturing trades, and other sources, which might cause complaints. In the suburbs, wastewater treatment plants, landfill sites, and other infrastructures are the expected major odour sources. These problems are often caused be the accelerated growth of cities. In rural sites, livestock farming and the spreading of manure on the fields is blamed for severe odour annoyance. In fact, environmental odours are considered to be a common cause of public complaints by residents to local authorities, regional, or national environmental agencies. This Special Issue of Atmosphere will address the entire chain, from the quantification of odour sources, abatement methods, the dilution in the atmosphere, and the assessment of odour exposure for the assessment of annoyance. In particular, this Special Issue aims to encourage contributions dealing with field trials and dispersion modeling to assess the degree of annoyance and the quantitative success of abatement measures.
    Keywords: environmental odour ; emission ; annoyance ; separation distance ; dispersion models ; empirical equations ; odour ; dispersion modelling ; wastewater treatment ; odour impact criteria ; separation distances ; odour legislation ; air quality ; air pollution ; odor ; smell ; odour units ; agriculture ; environmental regulations ; policy ; VOC ; GC-QTOF-MS ; GC-IMS ; wastewater treatment plant ; air dispersion model ; dose–response relationship ; odor impact criterion (OIC) ; perception-related odor exposure ; wastewater treatment plant (WWTP) ; Odors ; Odor Patrol ; Odor Profile Method ; monitoring Odors ; field inspection ; odour impact ; odour modelling ; olfactometry ; proficiency test ; bench loop ; n-butanol ; sampling uncertainties ; odorants ; SOAV ; OTV ; livestock ; odour dispersion modelling ; climate change ; stability classification ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-07-06
    Description: The road of acceptance of oncologic thermotherapy/hyperthermia as a synergistic modality in combination with standard oncologic therapies is still bumpy. This is partially due to the lack of level I evidence from international, multicentric, randomized clinical trials including large patient numbers and a long term follow-up. Therefore we need more level I EVIDENCE from clinical trials, we need HARMONISATION and global acceptance for existing technologies and a common language understood by all stakeholders and we need INNOVATION in the fields of biology, clinics and technology to move thermotherapy/hyperthermia forward. This is the main focus of this reprint. In this reprintyou find carefully selected and peer-reviewed contributions from Africa, America, Asia, and Europe. The published papers from leading scientists from all over the world covering a broad range of timely research topics might also help to strengthen thermotherapy on a global level.
    Keywords: perfusion estimation ; temperature monitoring ; conductivity reconstruction ; systems medicine ; immune system in silico ; perceptron ; antigen pattern ; danger signal ; fractionation ; immune response ; head and neck cancer ; hyperthermia ; reirradiation ; treatment outcome ; hyperthermia treatment planning ; adaptive planning ; temperature optimization ; low-middle-income group countries ; cancer ; radiotherapy ; chemotherapy ; recurrent breast cancers ; cervical cancer ; head and neck cancers ; cost-effective ; meta-analysis ; intensity-modulated radiotherapy ; prostate cancer ; thermal dose ; thermometric parameters ; preclinical data ; clinical evidence ; modulated electro-hyperthermia ; abscopal effect ; locally advanced cervical cancer ; resource-constrained setting ; radiosensitiser ; rectal cancer ; chemoradiotherapy ; tumour control ; loco-regional hyperthermia ; oncology ; cellular selection ; bioelectromagnetics ; complexity ; immune-effects ; moderate hyperthermia ; deep hyperthermia ; radiative hyperthermia ; patterns of care ; reimbursement ; regional hyperthermia ; neoadjuvant chemoradiation ; survival ; induced ; brachytherapy ; prostatic neoplasms ; interstitial hyperthermia ; treatment plan optimization ; prostate ; thermoradiotherapy ; linear quadratic model ; biological modeling ; thermal dosimetry ; hypoxia ; radiation therapy ; reoxygenation ; perfusion ; oxygen consumption rate ; local tumor control ; biomarker ; immune phenotype ; hyperthermia treatment sequence ; breast cancer ; immune checkpoint molecules ; dendritic cell activation ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: The advancements in research related to heat transfer has gathered much attention in recent decades following the quest for efficient thermal systems, interdisciplinary studies involving heat transfer, and energy research. Heat transfer, a fundamental transport phenomenon, has been considered one of the critical aspects for the development and advancement of many modern applications, including cooling, thermal systems which contain symmetry analysis, energy conservation and storage, and symmetry-preserving discretization of heat transfer in a complex turbulent flow. The objective of this book is to present recent advances, as well as up-to-date progress in all areas of heat transfer in engineering and its influence on emerging technologies.
    Keywords: heat generation ; internal short ; lithium-ion ; nail penetration ; temperature ; thermal abuse ; adaptive neuro-fuzzy interface system ; artificial neural network ; current ; power ; thermal efficiency ; thermoelectric generator system ; waste heat recovery ; efficiency ; power generation ; thermal stress ; thermoelectric module ; cooling and heating mode ; heat pump ; high-pressure chiller ; light-duty commercial electric vehicle ; system performance ; truncated twisted tape ; secondary flow ; laminar convective heat transfer ; performance evaluation criterion ; CFD ; heat exchanger ; cooling ; Lorentz force ; magnetohydrodynamics ; microchannel ; MHD pump ; thermoelectric system ; real-time polymerase chain reaction ; battery ; heating performance ; HVAC ; parallel ; serial ; economic ; energy saving ; hot water ; internal combustion engine ; waste heat ; heat transfer characteristics ; hybrid nanofluid ; performance evaluation criteria ; single particle nanofluid ; uniformly heated tube ; Bejan number ; microplate heat exchanger ; particle shape ; performance index ; thermodynamic analysis ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-12-06
    Description: This is a reprint of the MDPI IJERPH Special Issue entitled "COVID-19 and Environment: Impacts of a Global Pandemic". The reprint consists of 17 papers with different topics related to the COVID-19 pandemic and environmental impacts using data from different countries all over the globe.
    Keywords: risk perception ; China as an international tourism destination ; anticipated emotions ; destination attachment ; post-pandemic ; COVID-19 ; customer behavior ; psychological process ; live-streaming shopping apps ; stimulus-organism-response framework ; Unified Theory of Acceptance and Use of Technology 2 ; Flow Theory ; gender ; age ; SARS-CoV-2 ; environmental contamination ; air samples ; surface samples ; bottom trawling ; COVID-19 pandemic lockdown ; environmental impacts ; macrobenthic fauna ; tidal channels ; central Mediterranean Sea ; ethnopharmacology ; skin diseases ; cosmetics ; Lithuania ; global environment ; solid waste ; air quality ; transport ; airborne ; CO2 ; collective transport ; tramway ; filtration ; infectious diseases ; epidemiology ; public health ; elementary teacher ; junior high school teacher ; psychological change ; physical changes ; urban mobility ; parking demand ; IoT parking sensors ; explanatory data analysis ; parking policies ; vaccinations ; pharmacist ; KAP ; infection control ; burnout ; COVID-19 pandemic ; postnatal care ; psychological distress ; psychosocial support ; health-seeking behavior ; appendicitis ; surgical care ; metrology ; data analysis ; atmospheric environment ; pollution ; coronavirus ; comorbidity ; spatial analysis ; logistic regression ; ROC curve ; freight transport ; air freight ; sea shipping ; road transport ; recovery measures ; strategies ; public trust ; perceived societal fairness ; mental health ; air pollution ; PM2.5 concentration ; gym sports ; spatial econometric model ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: Cyber-physical system (CPS) innovations, in conjunction with their sibling computational and technological advancements, have positively impacted our society, leading to the establishment of new horizons of service excellence in a variety of applicational fields. With the rapid increase in the application of CPSs in safety-critical infrastructures, their safety and security are the top priorities of next-generation designs. The extent of potential consequences of CPS insecurity is large enough to ensure that CPS security is one of the core elements of the CPS research agenda. Faults, failures, and cyber-physical attacks lead to variations in the dynamics of CPSs and cause the instability and malfunction of normal operations. This reprint discusses the existing vulnerabilities and focuses on detection, prevention, and compensation techniques to improve the security of safety-critical systems.
    Keywords: smart grids ; device authentication ; situational awareness ; home area networks ; time-delay switch attack ; networked control systems ; secure control design ; Lyapunov theory ; attack estimation ; hardware-in-the-loop testing ; machine learning ; industrial control systems ; anomaly detection ; fault detection ; intrusion detection system ; blockchain ; security ; privacy ; financial transactions ; transportation systems ; autonomous vehicles ; power system resilience ; disaster ; Federated Learning ; edge intelligence ; resilience management systems ; resource-limitations ; demand response ; remedial testing ; greybox fuzzing ; vulnerability detection ; enhanced security ; traffic microsimulation tool ; cooperative automated driving systems ; vehicle powertrain ; safety ; road capacity ; contested environments ; anomaly isolation ; artificial neural networks ; Cyber Physical System ; out-of-bounds ; vulnerable detection ; patch ; inverter-based energy resources ; islanded microgrids ; resilient control design ; secondary control ; false data injection ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Dysregulation of Wnt signaling is known to be associated with various cancers. As such, identification of novel Wnt pathway targets in cancer and better characterization of already-known targets present exciting, emerging opportunities for cancer treatment. In this Special Issue, we feature papers which discuss the role of Wnt signaling and associated targets in cancer metabolism, tumor immune response, and tumor microenvironment. Papers discussing a range of Wnt-mediated cancers, including those of the colon, liver, pancreas, synovium, bladder, etc., are included.
    Keywords: Wnt signaling ; synovial sarcoma ; TNIK ; NCB-0846 ; MYC ; hepatitis B virus ; HBV ; cancer ; liver cancer ; β-catenin ; TCF/LEF ; pancreatic cancer ; pancreatic stellate cells ; CBP ; p300 ; pancreatitis ; fibrosis ; just-right signaling ; APC ; colorectal cancer ; RNA-binding proteins ; Musashi ; drug discovery ; Notch signaling ; cancer therapy ; fungi secondary metabolite derivative ; microenvironment ; Wnt ; AML ; drug target ; signaling ; colorectal ; porcupine ; R-spondin ; serrated ; immunotherapy ; wnt ; vitamin D ; colon cancer ; L1 ; Wnt target genes ; cell adhesion ; NF-κB ; invasion and metastasis ; cancer stem cells ; EMT ; Lgr5 ; Wnt/beta-catenin signaling ; angiogenesis ; anti-angiogenic therapy ; gastrointestinal cancers ; therapeutic targeting of Wnt signaling ; β-catenin paradox ; molecular targeting ; urothelial cancer ; immune checkpoint inhibitor ; immunotherapy resistance ; IBD ; colitis ; β-catenin mutations ; tumor metabolism ; tumor immunology ; molecular therapeutics ; precision medicine ; astrocytic brain tumors ; DKKs ; GSK3β ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: Breast cancer is acknowledged as an international priority in healthcare. It is currently the most common cancer in women worldwide, with demographic trends indicating a continuous increase in incidence. Over the years, increasing efforts and resources have been devoted to the search for a systematic and optimized strategy in breast cancer diagnosis and treatment. Today, the Breast Unit model is considered the gold standard in order to ensure optimal patient-centered and research-based clinical services through multidisciplinary and integrated management.Surgical treatment has gradually evolved toward less aggressive approaches with the adoption of new therapeutic strategies. The evolution of evidence-based guidelines in such leading disciplines as radiation and medical oncology has led to a steady improvement in survival rates. This Special Issue will highlight innovations in the integrated management of breast cancer, their potential advantages, and the many open issues that still need to be properly defined and addressed.
    Keywords: metastatic breast cancer ; breast surgery ; immune system ; metabolic derangements ; precision medicine ; integrated therapies ; advanced breast cancer ; mTOR inhibitor ; CDK4/6 inhibitor ; endocrine resistance ; breast cancer ; pregnancy ; chemotherapy ; tailoring ; personalization ; DataMart ; real world data ; predictive model ; healthcare ; breast-conserving surgery ; non-palpable breast lesions ; image-guided localization ; preoperative breast localization ; breast ultrasound ; large database ; standardized data collection ; networks ; nipple-sparing mastectomy ; immediate breast reconstruction ; acellular dermal matrix (ADM) ; aesthetic and oncological outcomes ; quality of life ; rare breast cancer ; osteoclast-like giant cells ; gene profiling ; Oncotype Dx ; adjuvant treatment ; neoadjuvant chemotherapy ; sentinel lymph node ; systemic treatment ; locally advanced breast cancer ; mini-invasive treatment ; liver metastases ; hepatic surgery ; personalized medicine ; sarcopenia ; physical performance ; frailty ; older cancer patients ; clinical trial ; patient enrollment ; artificial intelligence ; machine learning ; lung cancer ; oncology ; web app ; conventional CT and CT angiography ; DIEP flap planning ; multidisciplinary treatment ; evidence-based medicine ; personalized treatment ; oncological outcomes ; patient quality of life ; normal breast ; breast pathology ; hormone receptor ; hormone expression ; lymphedema ; lymphaticovenous anastomosis ; vascularized lymph node transfer ; lymphatic microsurgery ; radiotherapy ; oligometastatic breast cancer ; locoregional therapy ; CDK4/6 inhibitors ; multidisciplinary ; AMH ; ovarian reserve ; pregnancy desire ; subtypes breast cancer ; miRNAs ; breast cancer treatment ; next-generation-sequencing ; target therapy ; old age ; survival ; vitamin D ; ductal breast cancer ; in situ breast cancer ; lobular breast cancer ; histology ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-02-01
    Description: Anorexia nervosa is a common eating disorder affecting several functions of the body. Although our knowledge of the underlying mechanism has increased, therapeutic options are still limited. This Special Issue discusses several aspects of anorexia nervosa and covers a broad range of topics from the bench to the bedside.
    Keywords: Anorexia nervosa ; treatment contracts ; weight gain ; inpatient treatment ; survey ; accelerometry ; eating disorders ; motor restlessness ; physical inactivity ; anorexia nervosa ; cognitive behaviour therapy ; manualised treatment ; modules ; worksheets ; guidelines ; evidenced-based ; treatment ; emotion regulation ; males ; drug-treatment ; pharmacotherapy ; medication ; nutrition ; comorbidity ; complication ; functional magnetic resonance imaging ; disorder-specific stimuli ; narrative review ; immune system ; inflammation ; cytokines ; bic Book Industry Communication::M Medicine
    Language: English
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  • 98
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-09
    Description: The seeds and fruits (or their parts) of Iberoamerican crops have high nutritional and functional properties which could be utilized in a wide range of foods. The crops included in this book are amaranth (Amaranthus spp.), quinoa (Chenopodium quinoa), kañiwa (Chenopodium pallidicaule), chia (Salvia hispanica L.), Andean maize (Zea mays L.), moringa (Moringa oleifera), yvapuru (Plinia peruviana), kurugua (Sicana odorifera), sacha inchi (Plukenetia huayllabambana), camu camu (Myrciaria dubia), mango (Mangifera indica), tarwi (Lupinus mutabilis), peanut (Arachis hypogaea L.) and taro (Colocasia esculenta), all of them still underutilized. Their cultivation is low; nevertheless, in recent years, the worldwide demand for some of them has increased immensely, resulting in an increase in their production. The ancient Iberoamerican crops have been widely recognized for their nutritional value by food scientists and food producers because they contain high-quality proteins and large quantities of micronutrients such as minerals, vitamins and bioactive compounds. In addition, they are gluten-free, which makes them suitable for people suffering from various gluten intolerances. This book summarizes the large amount of investigations in this field in the last year and provides knowledge within all the relevant areas of food science. The editors hope that this book will contribute to an increased use of these products in human nutrition by consumers worldwide.
    Keywords: T1-995 ; History of engineering & technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-06-21
    Description: This SI presents the latest achievements, challenges and prospects for drives, actuators, sensors, controls and robot navigation with reverse validation and applications in the field of industrial automation and robotics. Automation, supported by robotics, can effectively speed up and improve production. The industrialization of complex mechatronic components, especially robots, requires a large number of special processes already in the pre-production stage provided by modelling and simulation. This area of research from the very beginning includes drives, process technology, actuators, sensors, control systems and all connections in mechatronic systems. Automation and robotics form broad-spectrum areas of research, which are tightly interconnected. To reduce costs in the pre-production stage and to reduce production preparation time, it is necessary to solve complex tasks in the form of simulation with the use of standard software products and new technologies that allow, for example, machine vision and other imaging tools to examine new physical contexts, dependencies and connections.
    Keywords: underground robots ; automation in mines ; remote control ; autonomous underground machinery ; robotic manipulator ; identification ; calibration ; Jacobian ; workcell layout detection ; QR code detection ; adaptive thresholding ; finder pattern ; perspective transformation ; smart buildings ; shared sensory system ; surveillance system ; localization ; marker detection ; manipulation ; design ; analytical calculation ; numerical analysis ; manipulation platform ; 3D deformable object ; grasping ; robust manipulation ; robot hand ; Matlab ; CoppeliaSim Edu ; V-Rep ; SolidWorks ; kinematics ; inverse kinematics (IK) ; manufacturing technology ; modular robots ; coordinate transformation ; industrial robot ; renishaw Ballbar QC20–W ; positional analysis ; measurement ; visual semantic SLAM ; semantic segmentation ; FPGA ; hardware acceleration ; mobile robots ; automated machining ; milling strategies ; geometrical tolerances ; assisted assembly ; mixed reality ; collaborative robot ; digital twin ; convolutional neural networks ; planar robotic arm ; pneumatic artificial muscle (PAM) ; gravity test ; dynamic model ; validation ; optimization ; trust region algorithm ; chimney ; cleaning ; in-pipe robot ; pneumatic actuator ; simulation ; pre-identification ; least squares method ; instrumental variable method ; robotics ; sensor ; antagonistic system ; pneumatic artificial muscles ; function ; model ; trajectory planning method ; hexapod robots ; legged robots ; triangle gait ; automation ; drives ; actuators ; sensors ; diagnostics ; holography ; virtual instrumentation ; control systems ; robot navigation ; reverse validation ; trajectory control ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2022-05-06
    Description: The production of industrial and bioenergy crops has been the subject of scientific research for many years; however, the implementation of previously proposed solutions for commercial production is still at an early stage. It should be emphasized that when developing the production of industrial and bioenergy crops on agricultural lands, it is important to avoid land-use competition with the production of food and feed. It is well justified, for initiating the sustainable production of industrial and bioenergy crops, to promote efficient species for growing on marginal lands, which are unsuitable or less suitable for food or feed production. Another important point is that industrial and bioenergy crops should include nonfood and nonfeed crops and generate agricultural products categorized as commodities and/or raw materials for industrial goods and bioenergy. These industrial and bioenergy crops can become an important source of biomass. Of course, the concept of their cultivation for nonfood (and/or nonfeed) uses is not new but, despite considerable investment in research and development, little progress has been made with regard to the introduction of such crops and their products into the market. Therefore, the papers focus on innovations and perspectives regarding sustainable industrial and bioenergy crops production, logistic chains, biomass quality, utilization and cascade biomass use for bioeconomy, socio-economic and energy analyses, etc.
    Keywords: harvesting ; work productivity ; supply chain ; harvesting efficiency ; Salix ; genoype × site interaction ; survivability ; biometric features ; plant height ; fresh biomass yield ; dry biomass yield ; Miscanthus ; nitrogen fertilization ; rhizomes ; stem ; leaves ; consumer choices ; eucalyptus ; firewood ; Italy ; multilevel logistic regression model ; willingness to consume ; tobacco biomass ; energy yield ; higher heating value ; biogas potential ; Nicotiana tabacum ; energy crops ; planting density ; calorific value ; SRC ; hulled wheat species ; energy ; life cycle assessment ; Tenebrio molitor ; edible insects ; larval development ; feed conversion ratio ; agricultural and industrial residues ; lignocellulosic biomass ; bioconversion ; agroforestry ; biodiversity ; bioeconomy ; biomass supply ; circular economy ; organic farming ; perennial crops ; quarry ; syntropy ; vegetation restoration ; willow ; varieties ; yield ; marginal soil ; biological diversity ; marginal land ; cup plant ; perennial energy crop ; energy expenses ; biogas ; biomass yield ; willow SRC ; energy plants ; ground beetles ; Carabidae ; ecosystem services ; invertebrate biodiversity ; willow-leaf sunflower ; Jerusalem artichoke ; supercritical extraction ; water as co-solvent ; antimicrobial activity ; biocidal effect ; bioenergy crop ; groundwater ; growth ; invasive potential ; reproductive potential ; Silphium perfoliatum ; soil moisture ; water table distance ; energy biomass ; yields ; invasive behavior ; economics ; common osier ; fertilization ; dry matter yield ; soil chemical parameters ; soil bulk density ; water-stable aggregates ; soil microbial carbon ; willow browse ; soluble carbohydrates ; browsing damage ; cervids ; gas chromatography ; aboveground ; belowground part of Miscanthus × giganteus ; ash ; potassium ; calcium ; sulphur content ; uptake ; bioproduction ; CAP payments ; sustainable agriculture ; Poland ; unutilized agricultural areas (uUAA) ; abandoned areas ; land use and land-use change ; carbon sequestration ; soil properties (physical and chemical) ; polyphenols ; supercritical CO2 extraction ; perennial industrial crops ; antioxidant activity ; silvergrass ; willowleaf sunflower ; prairie cordgrass ; n/a ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology
    Language: English
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