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  • 05.02. Data dissemination  (2)
  • ArenaviridaeendonucleasesLymphocytic choriomeningitis virusLCMVdiketo acidscompound optimizationmetal chelation  (1)
  • Springer  (2)
  • International Union of Crystallography (IUCr)  (1)
  • American Institute of Physics (AIP)
  • Taylor & Francis
  • 2015-2019  (3)
  • 1950-1954
  • 2018  (3)
  • 1
    Publication Date: 2018-03-19
    Description: The importance of historical earthquake data is largely recognized by both seismologists and engineers, who use such data in a wide range of applications. At the European-Mediterranean scale, several databases dealing with historical earthquake data – mostly intensity data points – exist and are constantly maintained and updated, as well as national earthquake catalogues. In addition, a number of studies on historical earthquakes are published every year. Most of these activities are being performed at a national scale, depending on each country’s needs, and according to diverse methodologies. As a result, the earthquake history of Europe is today fragmented in a puzzle of different, only partially overlapping sets of data, which, at the continent scale, are not homogeneously collected and interpreted. This situation is particularly evident in the frontier areas, where historical earthquakes are often interpreted in a conflicting and/or partial way by the catalogues of the bordering countries. In addition, the background information upon which several historical catalogues are built is not published or not easily accessible. In recent years, a major effort was made to bridge over these gaps, by establishing cooperation among existing national databases, and creating new ones according to common standards. Particular attention was devoted to retrieve the earthquake background information, that is, the results of historical earthquake investigation in terms of a paper, a report, a book chapter, a map, etc. As most of the information on an historical earthquake can be summarized in a set of Macroseismic Data Points (MDPs) – i.e. a list of localities (name and coordinates) with a macroseismic intensity assessment and the related macroseismic scale – a dedicated effort was addressed to make such data publicly available. The described activities resulted in the European Archive of Historical Earthquake Data (AHEAD). The Archive is conceived as a pan-European common and open platform supporting the research activities in the field of historical seismology by (i) tracing back, preserving and granting access to the sources of data on the earthquake history of Europe (papers, reports, MDPs, and catalogues), and (ii) establishing relations among these data. AHEAD inventories multiple sets of information concerning each European earthquake in the time-window 1000–1899. The AHEAD web portal (http://www.emidius.eu/AHEAD/) gives access, as of today, to 4,722 earthquakes and the related background information as provided by 338 data sources. All these data can be queried by earthquake and by study, through a user-friendly web-interface. The distinguishing feature of AHEAD is to grant access not only to one study, but to all the available (published) data sources dealing with each individual earthquake, allowing researchers to take into account the different point of views and interpretations.
    Description: Published
    Description: 359-369
    Description: 3T. Storia Sismica
    Description: 4T. Sismologia, geofisica e geologia per l'ingegneria sismica
    Description: 4IT. Banche dati
    Keywords: historical seismology ; seismicity ; historical earthquakes ; 04.06. Seismology ; 05.02. Data dissemination
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: book chapter
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  • 2
    Publication Date: 2022-05-24
    Description: Investigating relationships between macroseismic intensity and strong-motion data requires the existence of these two records for the same seismic event and site. In Italy, this comparison is feasible through the cross-matching of the Italian Macroseismic Database (DBMI) and the Italian Strong-Motion Database (ITACA) which are the most comprehensive sources of both data. However, the two databases lack a direct link which would allow performing joint analysis of macroseismic data points and strong-motion recordings, making the comparison a time consuming job for the researcher. This paper demonstrates the usefulness of cross-database identifiers, and presents their use in a webtool called Rosetta, an initial proof-of-concept that helped testing linking procedures among DBMI and ITACA, and user friendly visual solutions. The development allowed the working group to exchange expertise on their respective database structures and workflows, laying the groundwork for a consistent, low-maintenance, and durable solution that will be easily updatable each time a new version of DBMI or ITACA will be released.
    Description: Italian Department of Civil Protection to the project INGV-DPC S2-2014 “Constraining Observations into Seismic Hazard”
    Description: Published
    Description: 2429–2443
    Description: 3T. Storia Sismica
    Description: 4T. Sismologia, geofisica e geologia per l'ingegneria sismica
    Description: 4IT. Banche dati
    Description: JCR Journal
    Keywords: seismology ; macroseismic intensity ; strong-motion ; stations ; historical earthquakes ; database ; identifiers ; 04.06. Seismology ; 05.02. Data dissemination
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 3
    Publication Date: 2018-02-23
    Description: The Arenaviridae family, together with the Bunyaviridae and Orthomyxoviridae families, is one of the three negative-stranded RNA viral families that encode an endonuclease in their genome. The endonuclease domain is at the N-terminus of the L protein, a multifunctional protein that includes the RNA-dependent RNA polymerase. The synthesis of mRNA in arenaviruses is a process that is primed by capped nucleotides that are `stolen' from the cellular mRNA by the endonuclease domain in cooperation with other domains of the L protein. This molecular mechanism has been demonstrated previously for the endonuclease of the prototype Lymphocytic choriomeningitis virus (LCMV). However, the mode of action of this enzyme is not fully understood as the original structure did not contain catalytic metal ions. The pivotal role played by the cap-snatching process in the life cycle of the virus and the highly conserved nature of the endonuclease domain make it a target of choice for the development of novel antiviral therapies. Here, the binding affinities of two diketo-acid (DKA) compounds (DPBA and L-742,001) for the endonuclease domain of LCMV were evaluated using biophysical methods. X-ray structures of the LCMV endonuclease domain with catalytic ions in complex with these two compounds were determined, and their efficacies were assessed in an in vitro endonuclease-activity assay. Based on these data and computational simulation, two new DKAs were synthesized. The LCMV endonuclease domain exhibits a good affinity for these DKAs, making them a good starting point for the design of arenavirus endonuclease inhibitors. In addition to providing the first example of an X-ray structure of an arenavirus endonuclease incorporating a ligand, this study provides a proof of concept that the design of optimized inhibitors against the arenavirus endonuclease is possible.
    Keywords: ArenaviridaeendonucleasesLymphocytic choriomeningitis virusLCMVdiketo acidscompound optimizationmetal chelation
    Electronic ISSN: 2052-2525
    Topics: Geosciences , Physics
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