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  • Articles  (6,274)
  • Molecular Diversity Preservation International  (5,101)
  • Institute of Electrical and Electronics Engineers (IEEE)  (903)
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  • 2020-2022
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  • Articles  (6,274)
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  • 2020-2022
  • 2015-2019  (6,274)
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  • 1
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: This article proposes a 4D segmentation method by considering the 3D t data as a 4D hyper object, using a D4Q81 lattice in a lattice Bhatnagar-Gross-Krook (LBGK) simulation, where time is considered a fourth dimension for defining directions of particle momentum in the LBGK model. They implemented 4D-LBGK on 20 4D hypersphere and hypercube images with varying amounts of Gaussian noise added (0–300 percent). The average Dice values were 94.56 and 93.35 percent for the hypersphere and hypercube segmentations, respectively, demonstrating good segmentation accuracy. They also applied 4D-LBGK on 4D intracranial aneurysm CTA images and compared the results to five established segmentation methods, demonstrating that the proposed method is accurate and robust. The aneurysm segmentation was subsequently used in a LBGK-based biomechanics simulation to provide potentially novel information for understanding the physiology and treatment of intracranial aneurysms.
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  • 2
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: Trajectory design for missions to small bodies is tightly coupled both with the selection of targets for the mission and with the choice of spacecraft power, propulsion, and other hardware. Traditional methods of trajectory optimization have focused on finding the optimal trajectory for an a priori selection of destinations and spacecraft parameters. Recent research has expanded the field to multidisciplinary systems optimization that includes spacecraft parameters. The logical next step is to extend the optimization process to include target selection based not only on engineering figures of merit but also scientific value. This article presents a new technique to solve the multidisciplinary mission optimization problem for small-body missions, including classical trajectory design, the choice of spacecraft power and propulsion systems, and the scientific value of the targets. This technique, when combined with modern parallel computers, enables a holistic view of the small-body mission design process that previously required iteration among several different design processes.
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  • 3
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
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  • 4
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective : This paper investigates the multivariate oscillatory nature of electroencephalogram (EEG) signals in adaptive frequency scales for epileptic seizure detection. Methods : The empirical wavelet transform (EWT) has been explored for the multivariate signals in order to determine the joint instantaneous amplitudes and frequencies in signal adaptive frequency scales. The proposed multivariate extension of EWT has been studied on multivariate multicomponent synthetic signal, as well as on multivariate EEG signals of Children's Hospital Boston-Massachusetts Institute of Technology (CHB-MIT) scalp EEG database. In a moving-window-based analysis, 2-s-duration multivariate EEG signal epochs containing five automatically selected channels have been decomposed and three features have been extracted from each 1-s part of the 2-s-duration joint instantaneous amplitudes of multivariate EEG signals. The extracted features from each oscillatory level have been processed using a proposed feature processing step and joint features have been computed in order to achieve better discrimination of seizure and seizure-free EEG signal epochs. Results : The proposed detection method has been evaluated over 177 h of EEG records using six classifiers. We have achieved average sensitivity, specificity, and accuracy values as 97.91%, 99.57%, and 99.41%, respectively, using tenfold cross-validation method, which are higher than the compared state of art methods studied on this database. Conclusion : Efficient detection of epileptic seizure is achieved when seizure events appear for long duration in hours long EEG recordings. Significance : The proposed method develops time–frequency plane for multivariate signals and builds patient-specific models for EEG seizure detection.
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  • 5
    Publication Date: 2017-08-23
    Description: Objective: subthalamic nucleus deep brain stimulation (STN DBS) is limited by the occurrence of a pyramidal tract side effect (PTSE) induced by electrical activation of the pyramidal tract. Predictive models are needed to assist the surgeon during the electrode trajectory preplanning. The objective of the study was to compare two methods of PTSE prediction based on clinical assessment of PTSE induced by STN DBS in patients with Parkinson's disease. Methods: two clinicians assessed PTSE postoperatively in 20 patients implanted for at least three months in the STN. The resulting dataset of electroclinical tests was used to evaluate two methods of PTSE prediction. The first method was based on the volume of tissue activated (VTA) modeling and the second one was a data-driven-based method named Pyramidal tract side effect Model based on Artificial Neural network (PyMAN) developed in our laboratory. This method was based on the nonlinear correlation between the PTSE current threshold and the 3-D electrode coordinates. PTSE prediction from both methods was compared using Mann–Whitney U test. Results: 1696 electroclinical tests were used to design and compare the two methods. Sensitivity, specificity, positive- and negative-predictive values were significantly higher with the PyMAN method than with the VTA-based method ( P 〈 0.05). Conclusion: the PyMAN method was more effective than the VTA-based method to predict PTSE. Significance: this data-driven tool could help the neurosurgeon in predicting adverse side effects induced by DBS during the electrode trajectory preplanning.
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  • 6
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: We introduce novel methods to identify the active intervals (AIs) of intracardiac electrograms (IEGMs) during complex arrhythmias, such as atrial fibrillation (AF). Methods: We formulate the AI extraction problem, which consists of estimating the beginning and duration of the AIs, as a sequence of hypothesis tests. In each test, we compare the variance of a small portion of the bipolar IEGM with its adjacent segments. We propose modified general-likelihood ratio (MGLR) and separating-function-estimation tests; we derive five test statistics (TSs), and show that the AIs can be obtained by threshold crossing the TSs. We apply the proposed methods to the IEGM segments collected from the left atrium of 16 patients (62.4 $\pm$ 8.2-years old, four females, four paroxysmal, and twelve persistent AF) prior to catheter ablation. The accuracy of our methods is evaluated by comparing them with previously developed methods and manual annotation (MA). Results: Our results show a high level of similarity between the AIs of the proposed methods and MA, e.g., the true and false positive rates of one of the MGLR-based methods were, respectively, 97.8% and 1.4%. The mean absolute error from estimation of the onset and end of AIs and also for the estimation of the mean cycle length for that approach was 8.7 $\pm$ 10.5, 13 $\pm$ 15.5, and 4.2 $\pm$ 9.4 ms, respectively. Conclusion: The proposed methods can accurately identify onset and duration of AI of the IEGM during AF. Significance: The proposed methods can be used for real-time automated analysis of A- , the most challenging complex arrhythmia.
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  • 7
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: Recently numerous methods have been proposed for estimating average heart rate using photoplethysmography (PPG) during physical activity, overcoming the significant interference that motion causes in PPG traces. We propose a new algorithm framework for extracting instantaneous heart rate from wearable PPG and Electrocardiogram (ECG) signals to provide an estimate of heart rate variability during exercise. Methods: For ECG signals, we propose a new spectral masking approach which modifies a particle filter tracking algorithm, and for PPG signals constrains the instantaneous frequency obtained from the Hilbert transform to a region of interest around a candidate heart rate measure. Performance is verified using accelerometry and wearable ECG and PPG data from subjects while biking and running on a treadmill. Results: Instantaneous heart rate provides more information than average heart rate alone. The instantaneous heart rate can be extracted during motion to an accuracy of 1.75 beats per min (bpm) from PPG signals and 0.27 bpm from ECG signals. Conclusion: Estimates of instantaneous heart rate can now be generated from PPG signals during motion. These estimates can provide more information on the human body during exercise. Significance: Instantaneous heart rate provides a direct measure of vagal nerve and sympathetic nervous system activity and is of substantial use in a number of analyzes and applications. Previously it has not been possible to estimate instantaneous heart rate from wrist wearable PPG signals.
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  • 8
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: We have developed an unobtrusive magnetic–acoustic fluid intake monitoring (MAFIM) system using a conventional stainless-steel roller-ball nipple to measure licking and drinking behavior in animals. Movements of a small permanent magnetic tracer attached to stainless-steel roller balls that operate as a tongue-actuated valve are sensed by a pair of three-axial magnetometers, and transformed into a time-series indicating the status of the ball (up or down), using a Gaussian mixture model based data-driven classifier. The sounds produced by the rise and fall of the roller balls are also recorded and classified to substantiate the magnetic data by an independent modality for a more robust solution. The operation of the magnetic and acoustic sensors is controlled by an embedded system, communicating via Universal Serial Bus (USB) with a custom-designed user interface, running on a PC. The MAFIM system has been tested in vivo with minipigs, accurately measuring various drinking parameters and licking patterns without constraints imposed by current lick monitoring systems, such as nipple access, animal-nipple contact, animal training, and complex parameter settings.
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  • 9
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: This study aimed to verify and compare the accuracy of energy expenditure (EE) prediction models using shoe-based motion detectors with embedded accelerometers. Methods: Three physical activity (PA) datasets (unclassified, recognition, and intensity segmentation) were used to develop three prediction models. A multiple classification flow and these models were used to estimate EE. The “unclassified” dataset was defined as the data without PA recognition, the “recognition” as the data classified with PA recognition, and the “intensity segmentation” as the data with intensity segmentation. The three datasets contained accelerometer signals (quantified as signal magnitude area (SMA)) and net heart rate (HR net ). The accuracy of these models was assessed according to the deviation between physically measured EE and model-estimated EE. Results: The variance between physically measured EE and model-estimated EE expressed by simple linear regressions was increased by 63% and 13% using SMA and HR net , respectively. The accuracy of the EE predicted from accelerometer signals is influenced by the different activities that exhibit different count-EE relationships within the same prediction model. Conclusion: The recognition model provides a better estimation and lower variability of EE compared with the unclassified and intensity segmentation models. Significance: The proposed shoe-based motion detectors can improve the accuracy of EE estimation and has great potential to be used to manage everyday exercise in real time.
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  • 10
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: The standard chronic wound assessment method based on visual examination is potentially inaccurate and also represents a significant clinical workload. Hence, computer-based systems providing quantitative wound assessment may be valuable for accurately monitoring wound healing status, with the wound area the best suited for automated analysis. Here, we present a novel approach, using support vector machines (SVM) to determine the wound boundaries on foot ulcer images captured with an image capture box, which provides controlled lighting and range. After superpixel segmentation, a cascaded two-stage classifier operates as follows: in the first stage, a set of k binary SVM classifiers are trained and applied to different subsets of the entire training images dataset, and incorrectly classified instances are collected. In the second stage, another binary SVM classifier is trained on the incorrectly classified set. We extracted various color and texture descriptors from superpixels that are used as input for each stage in the classifier training. Specifically, color and bag-of-word representations of local dense scale invariant feature transformation features are descriptors for ruling out irrelevant regions, and color and wavelet-based features are descriptors for distinguishing healthy tissue from wound regions. Finally, the detected wound boundary is refined by applying the conditional random field method. We have implemented the wound classification on a Nexus 5 smartphone platform, except for training which was done offline. Results are compared with other classifiers and show that our approach provides high global performance rates (average sensitivity = 73.3%, specificity = 94.6%) and is sufficiently efficient for a smartphone-based image analysis.
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  • 11
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: The purpose of this paper is to describe a semiautomated segmentation method for the liver and evaluate its performance on CT-scan and MR images. Methods: First, an approximate 3-D model of the liver is initialized from a few user-generated contours to globally outline the liver shape. The model is then automatically deformed by a Laplacian mesh optimization scheme until it precisely delineates the patient's liver. A correction tool was implemented to allow the user to improve the segmentation until satisfaction. Results: The proposed method was tested against 30 CT-scans from the SLIVER07 challenge repository and 20 MR studies from the Montreal University Hospital Center, covering a wide spectrum of liver morphologies and pathologies. The average volumetric overlap error was 5.1% for CT and 7.6% for MRI and the average segmentation time was 6 min. Conclusion: The obtained results show that the proposed method is efficient, reliable, and could effectively be used routinely in the clinical setting. Significance: The proposed approach can alleviate the cumbersome and tedious process of slice-wise segmentation required for precise hepatic volumetry, virtual surgery, and treatment planning.
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  • 12
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Goal : Interictal high-frequency oscillations (HFOs [30–600 Hz]) have proven to be relevant biomarkers in epilepsy. In this paper, four categories of HFOs are considered: Gamma ([30–80 Hz]), high-gamma ([80–120 Hz]), ripples ([120–250 Hz]), and fast-ripples ([250–600 Hz]). A universal detector of the four types of HFOs is proposed. It has the advantages of 1) classifying HFOs, and thus, being robust to inter and intrasubject variability; 2) rejecting artefacts, thus being specific. Methods : Gabor atoms are tuned to cover the physiological bands. Gabor transform is then used to detect HFOs in intracerebral electroencephalography (iEEG) signals recorded in patients candidate to epilepsy surgery. To extract relevant features, energy ratios, along with event duration, are investigated. Discriminant ratios are optimized so as to maximize among the four types of HFOs and artefacts. A multiclass support vector machine (SVM) is used to classify detected events. Pseudoreal signals are simulated to measure the performance of the method when the ground truth is known. Results : Experiments are conducted on simulated and on human iEEG signals. The proposed method shows high performance in terms of sensitivity and false discovery rate. Conclusion : The methods have the advantages of detecting and discriminating all types of HFOs as well as avoiding false detections caused by artefacts. Significance : Experimental results show the feasibility of a robust and universal detector.
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  • 13
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Describes the above-named upcoming conference event. May include topics to be covered or calls for papers.
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  • 14
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Presents a listing of the handling editors for this issue of the publication.
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  • 15
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Describes the above-named upcoming conference event. May include topics to be covered or calls for papers.
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  • 16
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: By modeling the cochlear implant (CI) electrode-to-nerve interface and quantifying electrode discriminability in the model, we address the questions of how many individual channels can be distinguished by CI recipients and the extent to which performance might be improved by inserting electrodes deeper into the cochlea. Method: We adapt an artificial neural network to model electrode discrimination as well as a commonly used psychophysical measure (four-interval forced-choice) in CI stimulation and predict how well the locations of the stimulating electrodes can be inferred from simulated auditory nerve spiking patterns. Results: We show that a longer electrode leads to better electrode place discrimination in our model. For a simulated four-interval forced-choice procedure, correct classification rates significantly reduce with decreasing distance between the test electrodes and the reference electrodes, and higher correct classification rates may be achieved by the basal electrodes than apical electrodes. Conclusion: Our results suggest that enhanced electrode discriminability results from a longer CI electrode array, and the locations where the errors occur along the electrode array are not only affected by the distance between electrodes but also the twirling angle between electrodes. Significance: Our models and simulations provide theoretical insights into several important clinically relevant problems that will inform future designs of CI electrode arrays and stimulation strategies.
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  • 17
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: Episodes of bradycardia are common and recur sporadically in preterm infants, posing a threat to the developing brain and other vital organs. We hypothesize that bradycardias are a result of transient temporal destabilization of the cardiac autonomic control system and that fluctuations in the heart rate signal might contain information that precedes bradycardia. We investigate infant heart rate fluctuations with a novel application of point process theory. Methods: In ten preterm infants, we estimate instantaneous linear measures of the heart rate signal, use these measures to extract statistical features of bradycardia, and propose a simplistic framework for prediction of bradycardia. Results: We present the performance of a prediction algorithm using instantaneous linear measures (mean area under the curve = 0.79 ± 0.018) for over 440 bradycardia events. The algorithm achieves an average forecast time of 116 s prior to bradycardia onset (FPR = 0.15). Our analysis reveals that increased variance in the heart rate signal is a precursor of severe bradycardia. This increase in variance is associated with an increase in power from low content dynamics in the LF band (0.04–0.2 Hz) and lower multiscale entropy values prior to bradycardia. Conclusion: Point process analysis of the heartbeat time series reveals instantaneous measures that can be used to predict infant bradycardia prior to onset. Significance: Our findings are relevant to risk stratification, predictive monitoring, and implementation of preventative strategies for reducing morbidity and mortality associated with bradycardia in neonatal intensive care units.
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  • 18
    Publication Date: 2017-09-02
    Description: In the above paper [1] , the first footnote should have indicated the following information: A. H. Abdi and C. Luong are joint first authors.
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  • 19
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
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  • 20
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: Modernizing SW4 for massively parallel time-domain simulations of earthquake ground motions in 3D earth models increases resolution and provides ground motion estimates for critical infrastructure risk evaluations. Simulations of ground motions from large (M ≥ 7.0) earthquakes require domains on the order of 100 to500 km and spatial granularity on the order of 1 to5 m resulting in hundreds of billions of grid points. Surface-focused structured mesh refinement (SMR) allows for more constant grid point per wavelength scaling in typical Earth models, where wavespeeds increase with depth. In fact, MR allows for simulations to double the frequency content relative to a fixed grid calculation on a given resource. The authors report improvements to the SW4 algorithm developed while porting the code to the Cori Phase 2 (Intel Xeon Phi) systems at the National Energy Research Scientific Computing Center (NERSC) at Lawrence Berkeley National Laboratory. Investigations of the performance of the innermost loop of the calculations found that reorganizing the order of operations can improve performance for massive problems.
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  • 21
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: From the development of proxy applications to rapidly explore algorithmic and programming model changes and co-design of hardware and software features between vendors and application teams well in advance of delivery to early access to hardware and software stacks through dedicated hands-on activities with vendors, the articles in this special issue provide others with a starting point for their own roadmap to application modernization efforts.
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  • 22
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: Completing a full replication study of the authors’ previously published findings on bluff-body aerodynamics was harder than they thought, despite them having good reproducible-research practices, such as sharing their code and data openly. Here’s what they learned from three years, four computational fluid dynamics codes, and hundreds of runs.
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  • 23
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: Andres Kwasinski reviews “Signals and Systems” by Sanjit K. Mitra, a book that simply and efficiently presents the material it teaches through effective design decisions.
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  • 24
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: A decade of discourse to capture the essence of computational thinking has resulted in a broad set of skills whose teaching continue to pose challenges because of the reliance on the use of electronic computers and programming concepts. This article not only links computational thinking skills to fundamental cognitive competencies but also describes pedagogical tools that have proven effective in teaching them at early ages.
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  • 25
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
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  • 26
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
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  • 27
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
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  • 28
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: EIC Jim X. Chen looks at the latest trends in virtual reality.
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  • 29
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: This article presents recent progress in understanding solar wind–Mars interaction using a sophisticated global magnetohydrodynamic (MHD) model. Mars has localized crustal magnetic fields, so the solar wind plasma flow interacts directly with the Mars atmosphere/ionosphere system. Such an interaction generates an induced current in the ionosphere, modifies the magnetic field environment around Mars, and more importantly, causes the erosion of the Mars atmosphere. The nonuniformly distributed crustal magnetic field also plays an important role in the interaction process, which is modulated by planetary rotation. Recent advances in computing power allow the inclusion of the continuous crustal field rotation in the simulation with a time-dependent MHD model. Model results have been validated with observations from previous and ongoing Mars missions. The validated time-dependent MHD model is useful in quantifying the variation of ion loss rates with planet rotation and the internal response time scale of the Martian ionosphere.
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  • 30
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Articles in this special issue explore computational topics related to the solar system.
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  • 31
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: The threat of obesity, diabetes, anorexia, and bulimia in our society today has motivated extensive research on dietary monitoring. Standard self-report methods such as 24-h recall and food frequency questionnaires are expensive, burdensome, and unreliable to handle the growing health crisis. Long-term activity monitoring in daily living is a promising approach to provide individuals with quantitative feedback that can encourage healthier habits. Although several studies have attempted automating dietary monitoring using wearable, handheld, smart-object, and environmental systems, it remains an open research problem. This paper aims to provide a comprehensive review of wearable and hand-held approaches from 2004 to 2016. Emphasis is placed on sensor types used, signal analysis and machine learning methods, as well as a benchmark of state-of-the art work in this field. Key issues, challenges, and gaps are highlighted to motivate future work toward development of effective, reliable, and robust dietary monitoring systems.
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  • 32
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: Segmentation of skin lesions is an important step in the automated computer aided diagnosis of melanoma. However, existing segmentation methods have a tendency to over- or under-segment the lesions and perform poorly when the lesions have fuzzy boundaries, low contrast with the background, inhomogeneous textures, or contain artifacts. Furthermore, the performance of these methods are heavily reliant on the appropriate tuning of a large number of parameters as well as the use of effective preprocessing techniques, such as illumination correction and hair removal. Methods: We propose to leverage fully convolutional networks (FCNs) to automatically segment the skin lesions. FCNs are a neural network architecture that achieves object detection by hierarchically combining low-level appearance information with high-level semantic information. We address the issue of FCN producing coarse segmentation boundaries for challenging skin lesions (e.g., those with fuzzy boundaries and/or low difference in the textures between the foreground and the background) through a multistage segmentation approach in which multiple FCNs learn complementary visual characteristics of different skin lesions; early stage FCNs learn coarse appearance and localization information while late-stage FCNs learn the subtle characteristics of the lesion boundaries. We also introduce a new parallel integration method to combine the complementary information derived from individual segmentation stages to achieve a final segmentation result that has accurate localization and well-defined lesion boundaries, even for the most challenging skin lesions. Results: We achieved an average Dice coefficient of 91.18% on the ISBI 2016 Skin Lesion Challenge dataset and 90.66% on the PH2 dataset. Conclusion and Significance: Our extensive experimental results on two well-established public b- nchmark datasets demonstrate that our method is more effective than other state-of-the-art methods for skin lesion segmentation.
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  • 33
    Publication Date: 2017-08-23
    Description: Objective: In this paper, we present and test a new method for the identification and removal of nonstationary utility line noise from biomedical signals. Methods : The method, band limited atomic sampling with spectral tuning (BLASST), is an iterative approach that is designed to 1) fit nonstationarities in line noise by searching for best-fit Gabor atoms at predetermined time points, 2) self-modulate its fit by leveraging information from frequencies surrounding the target frequency, and 3) terminate based on a convergence criterion obtained from the same surrounding frequencies. To evaluate the performance of the proposed algorithm, we generate several simulated and real instances of nonstationary line noise and test BLASST along with alternative filtering approaches. Results: We find that BLASST is capable of fitting line noise well and/or preserving local signal features relative to tested alternative filtering techniques. Conclusion : BLASST may present a useful alternative to bandpass, notch, or other filtering methods when experimentally relevant features have significant power in a spectrum that is contaminated by utility line noise, or when the line noise in question is highly nonstationary. Significance : This is of particular significance in electroencephalography experiments, where line noise may be present in the frequency bands of neurological interest and measurements are typically of low enough strength that induced line noise can dominate the recorded signals. In conjunction with this paper, the authors have released a MATLAB toolbox that performs BLASST on real, vector-valued signals (available at https://github.com/VisLab/blasst ).
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  • 34
    Publication Date: 2017-08-23
    Description: Objective: the purpose of this paper is to propose an optimal control problem formulation to estimate subject-specific Hill model muscle–tendon (MT-) parameters of the knee joint actuators by optimizing the fit between experimental and model-based knee moments. Additionally, this paper aims at determining which sets of functional motions contain the necessary information to identify the MT-parameters. Methods: the optimal control and parameter estimation problem underlying the MT-parameter estimation is solved for subject-specific MT-parameters via direct collocation using an electromyography-driven musculoskeletal model. The sets of motions containing sufficient information to identify the MT-parameters are determined by evaluating knee moments simulated based on subject-specific MT-parameters against experimental moments. Results: the MT-parameter estimation problem was solved in about 30 CPU minutes. MT-parameters could be identified from only seven of the 62 investigated sets of motions, underlining the importance of the experimental protocol. Using subject-specific MT-parameters instead of more common linearly scaled MT-parameters improved the fit between inverse dynamics moments and simulated moments by about 30% in terms of the coefficient of determination (from $\text{0.57} \pm \text{0.20}$ to $\text{0.74} \pm \text{0.14}$ ) and by about 26% in terms of the root mean square error (from $\text{15.98} \pm \text{6.85}$ to $\text{11.85} \pm \text{4.12}\,{\text{N}} \cdot {\text{m}}$ ). In particular, subject-specific MT-parameters of the knee flexors were very different from linearly scaled MT-parameters. Conclus- on: we introduced a computationally efficient optimal control problem formulation and provided guidelines for designing an experimental protocol to estimate subject-specific MT-parameters improving the accuracy of motion simulations. Significance: the proposed formulation opens new perspectives for subject-specific musculoskeletal modeling, which might be beneficial for simulating and understanding pathological motions.
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  • 35
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Goal: We use noninvasive data (body surface potential mapping, BSPM) to personalize the main parameters of a cardiac electrophysiological (EP) model for predicting the response to different pacing conditions. Methods: First, an efficient forward model is proposed, coupling the Mitchell–Schaeffer transmembrane potential model with a current dipole formulation. Then, we estimate the main parameters of the cardiac model: activation onset location and tissue conductivity. A large patient-specific database of simulated BSPM is generated, from which specific features are extracted to train a machine learning algorithm. The activation onset location is computed from a Kernel Ridge Regression and a second regression calibrates the global ventricular conductivity. Results: The evaluation of the results is done both on a benchmark dataset of a patient with premature ventricular contraction (PVC) and on five nonischaemic implanted cardiac resynchonization therapy (CRT) patients with a total of 21 different pacing conditions. Good personalization results were found in terms of the activation onset location for the PVC (mean distance error, MDE = 20.3 mm), for the pacing sites (MDE = 21.7 mm) and for the CRT patients (MDE = 24.6 mm). We tested the predictive power of the personalized model for biventricular pacing and showed that we could predict the new electrical activity patterns with a good accuracy in terms of BSPM signals. Conclusion: We have personalized the cardiac EP model and predicted new patient-specific pacing conditions. Significance: This is an encouraging first step towards a noninvasive preoperative prediction of the response to different pacing conditions to assist clinicians for CRT patient selection and therapy planning.
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  • 36
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: The proposed spectral CT method solves the constrained one-step spectral CT reconstruction (cOSSCIR) optimization problem to estimate basis material maps while modeling the nonlinear X-ray detection process and enforcing convex constraints on the basis map images. In order to apply the optimization-based reconstruction approach to experimental data, the presented method empirically estimates the effective energy-window spectra using a calibration procedure. The amplitudes of the estimated spectra were further optimized as part of the reconstruction process to reduce ring artifacts. A validation approach was developed to select constraint parameters. The proposed spectral CT method was evaluated through simulations and experiments with a photon-counting detector. Basis material map images were successfully reconstructed using the presented empirical spectral modeling and cOSSCIR optimization approach. In simulations, the cOSSCIR approach accurately reconstructed the basis map images (<1% error). In experiments, the proposed method estimated the low-density polyethylene region of the basis maps with 0.5% error in the PMMA image and 4% error in the aluminum image. For the Teflon region, the experimental results demonstrated 8% and 31% error in the PMMA and aluminum basis material maps, respectively, compared with −24% and 126% error without estimation of the effective energy window spectra, with residual errors likely due to insufficient modeling of detector effects. The cOSSCIR algorithm estimated the material decomposition angle to within 1.3 degree error, where, for reference, the difference in angle between PMMA and muscle tissue is 2.1 degrees. The joint estimation of spectral-response scaling coefficients and basis material maps was found to reduce ring artifacts in both a phantom and tissue sp- cimen. The presented validation procedure demonstrated feasibility for the automated determination of algorithm constraint parameters.
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  • 37
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: High-resolution, low-noise X-ray detectors based on CMOS active pixel sensor (APS) technology have demonstrated superior imaging performance for digital breast tomosynthesis (DBT). This paper presents a task-based model for a high-resolution medical imaging system to evaluate its ability to detect simulated microcalcifications and masses as lesions for breast cancer. A 3-D cascaded system analysis for a 50- $\mu \text{m}$ pixel pitch CMOS APS X-ray detector was integrated with an object task function, a medical imaging display model, and the human eye contrast sensitivity function to calculate the detectability index and area under the ROC curve (AUC). It was demonstrated that the display pixel pitch and zoom factor should be optimized to improve the AUC for detecting small microcalcifications. In addition, detector electronic noise of smaller than 300 e − and a high display maximum luminance (>1000 cd/cm $^{2})$ are desirable to distinguish microcalcifications of $150~\mu \text{m}$ in size. For low contrast mass detection, a medical imaging display with a minimum of 12-bit gray levels is recommended to realize accurate luminance levels. A wide projection angle range of greater than ±30° in combination with the image gray level magnification could improve the mass detectability especially when the anatomical background noise is high. On the other hand, a narrower projection angle range below ±20° can improve the small, high contrast object detection. Due to the low mass contrast and luminance, the ambient luminance should be controlled below 5 cd/ $\text{m}^{2}$ . Task-based modeling provides important firsthand imaging performance of the high-resolution CMOS-based medical imaging system that is still at early stage development for DBT. The modeling results could guide the prototype design and clinical studies in the future.
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  • 38
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: Contrast-enhanced digital mammography (CEDM) is an alternative to conventional X-ray mammography for imaging dense breasts. However, conventional approaches to CEDM require a double exposure of the patient, implying higher dose, and risk of incorrect image registration due to motion artifacts. A novel approach is presented, based on hyperspectral imaging, where a detector combining positional and high-resolution spectral information (in this case based on Cadmium Telluride) is used. This allows simultaneous acquisition of the two images required for CEDM. The approach was tested on a custom breast-equivalent phantom containing iodinated contrast agent (Niopam 150®). Two algorithms were used to obtain images of the contrast agent distribution: K-edge subtraction (KES), providing images of the distribution of the contrast agent with the background structures removed, and a dual-energy (DE) algorithm, providing an iodine-equivalent image and a water-equivalent image. The high energy resolution of the detector allowed the selection of two close-by energies, maximising the signal in KES images, and enhancing the visibility of details with the low surface concentration of contrast agent. DE performed consistently better than KES in terms of contrast-to-noise ratio of the details; moreover, it allowed a correct reconstruction of the surface concentration of the contrast agent in the iodine image. Comparison with CEDM with a conventional detector proved the superior performance of hyperspectral CEDM in terms of the image quality/dose tradeoff.
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  • 39
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: Prediction of treatment responses from available data is key to optimizing personalized treatment. Retinal diseases are treated over long periods and patients’ response patterns differ substantially, ranging from a complete response to a recurrence of the disease and need for re-treatment at different intervals. Linking observable variables in high-dimensional observations to outcome is challenging. In this paper, we present and evaluate two different data-driven machine learning approaches operating in a high-dimensional feature space: sparse logistic regression and random forests-based extra trees (ET). Both identify spatio-temporal signatures based on retinal thickness features measured in longitudinal spectral-domain optical coherence tomography (OCT) imaging data and predict individual patient outcome using these quantitative characteristics. We demonstrate on a data set of monthly SD-OCT scans of 155 patients with central retinal vein occlusion (CRVO) and 92 patients with branch retinal vein occlusion (BRVO) followed over one year that we can predict from initial three observations if the treated disease will recur within the covered interval. ET predicts the outcome on fivefold cross-validation with an area under the receiver operating characteristic curve (AuC) of 0.83 for BRVO and 0.76 for CRVO. Logistic regression achieved an AuC of 0.78 and 0.79, respectively. At the same time, the methods identified stable predictive signatures in the longitudinal imaging data that are the basis for accurate prediction. Furthermore, our results show that taking spatio-temporal features into account improves accuracy compared with features extracted at a single time-point. Our results demonstrate the feasibility of mining longitudinal data for predictive signatures, and building predictive models based on observed data.
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  • 40
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: It is essential for physicians to obtain the accurate venous tree from abdominal CT angiography (CTA) series in order to carry out the preoperative planning and intraoperative navigation for hepatic surgery. In this process, one of the important tasks is to separate the given liver venous mask into its hepatic and portal parts. In this paper, we present a novel method for liver venous tree separation. The proposed method first concentrates on extracting potential vessel intersection points between hepatic and portal venous systems. Then, the proposed method focuses on modeling the vessel intersection neigh-borhoods with a robust twin-line random sample consensus (RANSAC) shape detector. Finally, the proposed method conducts the venous tree separation based on the results of the twin-line RANSAC as well as physical constraints posed by Murray’s Law. We test our method on 22 clinical CTA series and demonstrate its effectiveness.
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  • 41
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: Angle-closure glaucoma is a major cause of irreversible visual impairment and can be identified by measuring the anterior chamber angle (ACA) of the eye. The ACA can be viewed clearly through anterior segment optical coherence tomography (AS-OCT), but the imaging characteristics and the shapes and locations of major ocular structures can vary significantly among different AS-OCT modalities, thus complicating image analysis. To address this problem, we propose a data-driven approach for automatic AS-OCT structure segmentation, measurement, and screening. Our technique first estimates initial markers in the eye through label transfer from a hand-labeled exemplar data set, whose images are collected over different patients and AS-OCT modalities. These initial markers are then refined by using a graph-based smoothing method that is guided by AS-OCT structural information. These markers facilitate segmentation of major clinical structures, which are used to recover standard clinical parameters. These parameters can be used not only to support clinicians in making anatomical assessments, but also to serve as features for detecting anterior angle closure in automatic glaucoma screening algorithms. Experiments on Visante AS-OCT and Cirrus high-definition-OCT data sets demonstrate the effectiveness of our approach.
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  • 42
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: The focus of the Internet has recently shifted from current computers and mobile devices to everyday objects, people, and places; consequently, the Internet of Things (IoT) promises to be not only a compelling vision but the actual driving force of the upcoming fourth Industrial Revolution. Novel cyber-physical, customized, and highly pervasive services are impacting our lives, involving several stakeholders and fostering an unseen globally interconnected ecosystem. However, IoT system development is a multifaceted process that’s complex, error-prone, and time-consuming. Although modeling and simulation are crucial aspects that could effectively support IoT system development, an integrated approach synergistically providing both of them is lacking. The authors propose a hybrid approach that uses agents for IoT modeling and OMNeT for simulation, providing mapping guidelines between the agent paradigm and the OMNeT simulator abstractions. The proposed approach has been applied in small-, medium-, and large-scale IoT scenarios, where relevant performance indexes of IoT entities communication have been measured and analyzed.
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  • 43
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: Two recent projects have harnessed supercomputing resources at the US Department of Energy’s Argonne National Laboratory in a novel way to support major fusion science and particle collider experiments. Using leadership computing resources, one team ran fine-grid analysis of real-time data to make near-real-time adjustments to an ongoing experiment, while a second team is working to integrate Argonne’s supercomputers into the Large Hadron Collider/ATLAS workflow. Together these efforts represent a new paradigm of the high-performance computing center as a partner in experimental science.
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  • 44
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: Blockchain is a new technology, based on hashing, which is at the foundation of the platforms for trading cryptocurrencies and executing smart contracts. This article reviews the basic ideas of this technology and provides a sample minimalist implementation in Python.
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  • 45
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
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  • 46
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: Columnist Charles Day describes a new dating app called Blur and how it stacks up to the human brain in matching potential mates.
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  • 47
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
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  • 48
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: The conventional wavelet transform is widely used in image and signal processing, where a signal is decomposed into a combination of known signals. By analyzing the individual contributions, the behavior of the original signal can be inferred. In this article, the authors present an introductory overview of the extension of this theory into graphs domains. They review the graph Fourier transform and graph wavelet transforms that are based on dictionaries of graph spectral filters, namely, spectral graph wavelet transforms. Then, the main features of the graph wavelet transforms are presented using real and synthetic data.
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  • 49
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: Semisupervised DR techniques using virtual label regression have attracted considerable attention, but they suffer from two restrictions: the number of discriminant directions available is constrained to the number of classes, and they’re nonorthogonal. Traditional methods easily address these problems. However, an interesting problem is how to address these restrictions in label regression modelings. To do this, the authors developed Recursive Orthogonal Label Regression (ROLR), a regression framework of semisupervised dimension reduction that uses label propagation and label regression in a recursive procedure. Here, they illustrate the formulation of ROLR using semisupervised regression encoding. ROLR provides an unified view to understand and explain a large family of label regression techniques. Experimental results show the approach’s feasibility and effectiveness.
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  • 50
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: Two recent projects have used the Cray XK7 Titan supercomputer at the US Department of Energy’s Oak Ridge National Laboratory to study Earth’s dynamics, specifically seismology-related studies. Using Titan, one team of researchers modeled Earth’s interior using earthquake data, while a second team developed physics-based earthquake simulations for disaster management applications. Together, the projects demonstrate how leadership-class supercomputing provides context to scientific discussions and informs decision making among civic leaders.
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  • 51
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: The ISO/IEC Fortran standards working group states that the third most detectable type of error in scientific software is “incorrect use of units of measurement” and has developed a draft specification for incorporating unit-checking into Fortran compilers. This article shows that unit-checking is insufficient to detect all quantity errors, and that kind-of-quantity also needs to be verified. A suggested syntax and program for a Fortran source-code preprocessor are given.
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  • 52
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Presents the table of contents for this issue of the publication.
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  • 53
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    Publication Date: 2017-08-23
    Description: Presents a listing of the editorial board, board of governors, current staff, committee members, and/or society editors for this issue of the publication.
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  • 54
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    Publication Date: 2017-08-23
    Description: Mobile technology is opening a wide range of opportunities for transforming the standard of care for chronic disorders. Using smartphones as tools for longitudinally tracking symptoms could enable personalization of drug regimens and improve patient monitoring. Parkinson's disease (PD) is an ideal candidate for these tools. At present, evaluation of PD signs requires trained experts to quantify motor impairment in the clinic, limiting the frequency and quality of the information available for understanding the status and progression of the disease. Mobile technology can help clinical decision making by completing the information of motor status between hospital visits. This paper presents an algorithm to detect PD by analyzing the typing activity on smartphones independently of the content of the typed text. We propose a set of touchscreen typing features based on a covariance, skewness, and kurtosis analysis of the timing information of the data to capture PD motor signs. We tested these features, both independently and in a multivariate framework, in a population of 21 PD and 23 control subjects, achieving a sensitivity/specificity of $0.81/0.81$ for the best performing feature and $0.73/0.84$ for the best multivariate method. The results of the alternating finger-tapping, an established motor test, measured in our cohort are $0.75/0.78$ . This paper contributes to the development of a home-based, high-compliance, and high-frequency PD motor test by analysis of routine typing on touchscreens.
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  • 55
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Presents the front cover for this issue of the publication.
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  • 56
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    Publication Date: 2017-08-23
    Description: Objective : The challenging task of heart rate (HR) estimation from the photoplethysmographic (PPG) signal, during intensive physical exercises, is tackled in this paper. Methods: The study presents a detailed analysis of a novel algorithm (WFPV) that exploits a Wiener filter to attenuate the motion artifacts, a phase vocoder to refine the HR estimate and user-adaptive post-processing to track the subject physiology. Additionally, an offline version of the HR estimation algorithm that uses Viterbi decoding is designed for scenarios that do not require online HR monitoring (WFPV+VD). The performance of the HR estimation systems is rigorously compared with existing algorithms on the publically available database of 23 PPG recordings. Results: On the whole dataset of 23 PPG recordings, the algorithms result in average absolute errors of 1.97 and 1.37 BPM in the online and offline modes, respectively. On the test dataset of 10 PPG recordings which were most corrupted with motion artifacts, WFPV has an error of 2.95 BPM on its own and 2.32 BPM in an ensemble with two existing algorithms. Conclusion: The error rate is significantly reduced when compared with the state-of-the art PPG-based HR estimation methods. Significance : The proposed system is shown to be accurate in the presence of strong motion artifacts and in contrast to existing alternatives has very few free parameters to tune. The algorithm has a low computational cost and can be used for fitness tracking and health monitoring in wearable devices. The MATLAB implementation of the algorithm is provided online.
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  • 57
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    Publication Date: 2017-08-23
    Description: Objective : State-of-the-art techniques for surgical data analysis report promising results for automated skill assessment and action recognition. The contributions of many of these techniques, however, are limited to study-specific data and validation metrics, making assessment of progress across the field extremely challenging. Methods : In this paper, we address two major problems for surgical data analysis: First, lack of uniform-shared datasets and benchmarks, and second, lack of consistent validation processes. We address the former by presenting the JHU-ISI Gesture and Skill Assessment Working Set (JIGSAWS), a public dataset that we have created to support comparative research benchmarking. JIGSAWS contains synchronized video and kinematic data from multiple performances of robotic surgical tasks by operators of varying skill. We address the latter by presenting a well-documented evaluation methodology and reporting results for six techniques for automated segmentation and classification of time-series data on JIGSAWS. These techniques comprise four temporal approaches for joint segmentation and classification: hidden Markov model, sparse hidden Markov model (HMM), Markov semi-Markov conditional random field, and skip-chain conditional random field; and two feature-based ones that aim to classify fixed segments: bag of spatiotemporal features and linear dynamical systems. Results : Most methods recognize gesture activities with approximately 80% overall accuracy under both leave-one-super-trial-out and leave-one-user-out cross-validation settings. Conclusion : Current methods show promising results on this shared dataset, but room for significant progress remains, particularly for consistent prediction of gesture activities across different surgeons. Significance : The results reported in this paper provide the first systematic and uniform evaluatio- of surgical activity recognition techniques on the benchmark database.
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    Publication Date: 2017-08-23
    Description: Objective: An in vivo kinetic framework is introduced to analyze and predict the quantitative advantage of using nanocarriers to deliver drugs, especially anticancer agents, compared to administering the same drugs in their free form. Methods: This framework recognizes three levels of kinetics. First is the particokinetics associated with deposition of nanocarriers into tissues associated with drug effect and toxicity, their residence inside those tissues, and elimination of the nanocarriers from the body. Second is the release pattern in time of free drug from the nanocarriers. Third is the pharmacokinetics of free drug, as it relates to deposition and elimination processes in the target and toxicity associated tissues, and total body clearance. A figure of merit, the drug targeting index (DTI), is used to quantitate the benefit of nanocarrier-based drug delivery by considering the effects of preferential deposition of nanoparticles into target tissues and relative avoidance of tissues associated with drug toxicity, compared to drug that is administered in its free form. Results: General methods are derived for calculating DTI when appropriate particokinetic, pharmacokinetic, and drug release rate information is available, and it is shown that relatively simple algebraic forms result when some common assumptions are made. Conclusion: This approach may find use in developing and selecting nanocarrier formulations, either for populations or for individuals.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: The measurement and analysis of electrodermal activity (EDA) offers applications in diverse areas ranging from market research to seizure detection and to human stress analysis. Unfortunately, the analysis of EDA signals is made difficult by the superposition of numerous components that can obscure the signal information related to a user's response to a stimulus. We show how simple preprocessing followed by a novel compressed sensing based decomposition can mitigate the effects of the undesired noise components and help reveal the underlying physiological signal. The proposed framework allows for decomposition of EDA signals with provable bounds on the recovery of user responses. We test our procedure on both synthetic and real-world EDA signals from wearable sensors and demonstrate that our approach allows for more accurate recovery of user responses as compared with the existing techniques.
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  • 60
    Publication Date: 2017-08-23
    Description: Objective: An autoencoder-based framework that simultaneously reconstruct and classify biomedical signals is proposed. Previous work has treated reconstruction and classification as separate problems. This is the first study that proposes a combined framework to address the issue in a holistic fashion. Methods: For telemonitoring purposes, reconstruction techniques of biomedical signals are largely based on compressed sensing (CS); these are “designed” techniques where the reconstruction formulation is based on some “assumption” regarding the signal. In this study, we propose a new paradigm for reconstruction—the reconstruction is “learned,” using an autoencoder; it does not require any assumption regarding the signal as long as there is sufficiently large training data. But since the final goal is to analyze/classify the signal, the system can also learn a linear classification map that is added inside the autoencoder. The ensuing optimization problem is solved using the Split Bregman technique. Results: Experiments were carried out on reconstructing and classifying electrocardiogram (ECG) (arrhythmia classification) and EEG (seizure classification) signals. Conclusion: Our proposed tool is capable of operating in a semi-supervised fashion. We show that our proposed method is better in reconstruction and more than an order magnitude faster than CS based methods; it is capable of real-time operation. Our method also yields better results than recently proposed classification methods. Significance: This is the first study offering an alternative to CS-based reconstruction. It also shows that the representation learning approach can yield better results than traditional methods that use hand-crafted features for signa- analysis.
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  • 61
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    Publication Date: 2017-08-23
    Description: Remote points-of-care has recently had a lot of attention for their advantages such as saving lives and cost reduction. The transmitted streams usually contain 1) normal biomedical signals (e.g., electrocardiograms) and 2) highly private information (e.g., patient identity). Despite the obvious advantages, the primary concerns are privacy and authenticity of the transferred data. Therefore, this paper introduces a novel steganographic mechanism that ensures 1) strong privacy preservation of private information by random concealing inside the transferred signals employing a key and 2) evidence of originality for the biomedical signals. To maximize hiding, fast Walsh–Hadamard transform is utilized to transform the signals into a group of coefficients. To ensure the lowest distortion, only less-significant values of coefficients are employed. To strengthen security, the key is utilized in a three-dimensional (3-D) random coefficients’ reform to produce a 3-D order employed in the concealing process. The resultant distortion has been thoroughly measured in all stages. After extensive experiments on three types of signals, it has been proved that the algorithm has a little impact on the genuine signals ( $〈$ 1 %). The security evaluation also confirms that unlawful retrieval of the hidden information within rational time is mightily improbable.
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  • 62
    Publication Date: 2017-08-23
    Description: Objective: For long-term electrocardiography (ECG) recordings, accurate R-wave detection is essential. Several algorithms have been proposed but not yet compared on large, noisy, or pathological data, since manual ground-truth establishment is impossible on such large data. Methods: We apply the simultaneous truth and performance level estimation (STAPLE) method to ECG signals comparing nine R-wave detectors: Pan and Tompkins (1985), Chernenko (2007), Arzeno et al. (2008), Manikandan et al. (2012), Lentini et al. (2013), Sartor et al. (2014), Liu et al. (2014), Arteaga-Falconi et al. (2015), and Khamis et al. (2016). Experiments are performed on the MIT-BIH database, TELE database, PTB database, and 24/7 Holter recordings of 60 multimorbid subjects. Results: Existing approaches on R-wave detection perform excellently on healthy subjects (F-measure above 99% for most methods), but performance drops to a range of F = 90.10% (Khamis et al. ) to F = 30.10% (Chernenko) when analyzing the 37 million R-waves of multimorbid subjects. STAPLE improves existing approaches (Δ F = 0.04 for the MIT-BIH database and Δ F = 0.95 for the TELE database) and yields a relative (not absolute) scale to compare algorithms’ performances. Conclusion: More robust R-wave detection methods or flexible combinations are required to analyze continuous data captured from pathological subjects or that is recorded with dropouts and noise. Significance: STAPLE algorithm has been adopted from image to signal analysis to compare algori- hms on large, incomplete, and noisy data without manual ground truth. Existing approaches on R-wave detection weakly perform on such data.
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  • 63
    Publication Date: 2017-08-23
    Description: Goal : Accurate determination of the epileptogenic focus is of paramount diagnostic and therapeutic importance in epilepsy. The current gold standard for focus localization is from ictal (seizure) onset and thus requires the occurrence and recording of multiple typical seizures of a patient. Localization of the focus from seizure-free (interictal) periods remains a challenging problem, especially in the absence of interictal epileptiform activity. Methods : By exploring the concept of effective inflow, we developed a focus localization algorithm (FLA) based on directed connectivity between brain sites. Subsequently, using the measure of generalized partial directed coherence over a broad frequency band in FLA for the analysis of interictal periods from long-term (days) intracranial electroencephalographic signals, we identified the brain region that is the most frequent receiver of maximal effective inflow from other brain regions. Results : In six out of nine patients with temporal lobe epilepsy, the thus identified brain region was a statistically significant outlier ( p 〈 0.01) and coincided with the clinically assessed epileptogenic focus. In the remaining three patients, the clinically assessed focus still exhibited the highest inflow, but it was not deemed an outlier ( p > 0.01). Conclusions : These findings suggest that the epileptogenic focus is a region of intense influence from other regions interictally, possibly as a mechanism to keep it under control in seizure-free periods. Significance : The developed framework is expected to assist with the accurate epileptogenic focus localization, reduce hospital stay and healthcare cost, and provide guidance to treatment of epilepsy via resective surgery or neuromodulation.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: Most trainees begin learning robotic minimally invasive surgery by performing inanimate practice tasks with clinical robots such as the Intuitive Surgical da Vinci. Expert surgeons are commonly asked to evaluate these performances using standardized five-point rating scales, but doing such ratings is time consuming, tedious, and somewhat subjective. This paper presents an automatic skill evaluation system that analyzes only the contact force with the task materials, the broad-bandwidth accelerations of the robotic instruments and camera, and the task completion time. Methods: We recruited $N = 38$ participants of varying skill in robotic surgery to perform three trials of peg transfer with a da Vinci Standard robot instrumented with our Smart Task Board. After calibration, three individuals rated these trials on five domains of the Global Evaluative Assessment of Robotic Skill (GEARS) structured assessment tool, providing ground-truth labels for regression and classification machine learning algorithms that predict GEARS scores based on the recorded force, acceleration, and time signals. Results: Both machine learning approaches produced scores on the reserved testing sets that were in good to excellent agreement with the human raters, even when the force information was not considered. Furthermore, regression predicted GEARS scores more accurately and efficiently than classification. Conclusion: A surgeon's skill at robotic peg transfer can be reliably rated via regression using features gathered from force, acceleration, and time sensors external to the robot. Significance: We expect improved trainee learning as a result of providing these automatic skill ratings during inanimate task practice on a surgical robot.
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  • 65
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: These instructions give guidelines for preparing papers for this publication. Presents information for authors publishing in this journal.
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  • 66
    Publication Date: 2017-08-23
    Description: Goal: Bucking the trend of big data, in microdevice engineering, small sample size is common, especially when the device is still at the proof-of-concept stage. The small sample size, small interclass variation, and large intraclass variation, have brought biosignal analysis new challenges. Novel representation and classification approaches need to be developed to effectively recognize targets of interests with the absence of a large training set. Methods: Moving away from the traditional signal analysis in the spatiotemporal domain, we exploit the biosignal representation in the topological domain that would reveal the intrinsic structure of point clouds generated from the biosignal. Additionally, we propose a Gaussian-based decision tree (GDT), which can efficiently classify the biosignals even when the sample size is extremely small. Results: This study is motivated by the application of mastitis detection using low-voltage alternating current electrokinetics (ACEK) where five categories of bisignals need to be recognized with only two samples in each class. Experimental results demonstrate the robustness of the topological features as well as the advantage of GDT over some conventional classifiers in handling small dataset. Conclusion: Our method reduces the voltage of ACEK to a safe level and still yields high-fidelity results with a short assay time. Significance: This paper makes two distinctive contributions to the field of biosignal analysis, including performing signal processing in the topological domain and handling extremely small dataset. Currently, there have been no related works that can efficiently tackle the dilemma between avoiding electrochemical reaction and accelerating assay process using ACEK.
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    Publication Date: 2017-09-02
    Description: Presents the table of contents for this issue of the publication.
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    Publication Date: 2017-09-02
    Description: The objective of electrical impedance tomographic reconstruction is to identify the distribution of tissue conductivity from electrical boundary conditions. This is an ill-posed inverse problem usually solved under the finite-element method framework. In previous studies, standard sparse regularization was used for difference electrical impedance tomography to achieve a sparse solution. However, regarding elementwise sparsity, standard sparse regularization interferes with the smoothness of conductivity distribution between neighboring elements and is sensitive to noise. As an effect, the reconstructed images are spiky and depict a lack of smoothness. Such unexpected artifacts are not realistic and may lead to misinterpretation in clinical applications. To eliminate such artifacts, we present a novel sparse regularization method that uses spectral graph wavelet transforms. Single-scale or multiscale graph wavelet transforms are employed to introduce local smoothness on different scales into the reconstructed images. The proposed approach relies on viewing finite-element meshes as undirected graphs and applying wavelet transforms derived from spectral graph theory. Reconstruction results from simulations, a phantom experiment, and patient data suggest that our algorithm is more robust to noise and produces more reliable images.
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    Publication Date: 2017-09-02
    Description: Automatic skin lesion segmentation in dermoscopic images is a challenging task due to the low contrast between lesion and the surrounding skin, the irregular and fuzzy lesion borders, the existence of various artifacts, and various imaging acquisition conditions. In this paper, we present a fully automatic method for skin lesion segmentation by leveraging 19-layer deep convolutional neural networks that is trained end-to-end and does not rely on prior knowledge of the data. We propose a set of strategies to ensure effective and efficient learning with limited training data. Furthermore, we design a novel loss function based on Jaccard distance to eliminate the need of sample re-weighting, a typical procedure when using cross entropy as the loss function for image segmentation due to the strong imbalance between the number of foreground and background pixels. We evaluated the effectiveness, efficiency, as well as the generalization capability of the proposed framework on two publicly available databases. One is from ISBI 2016 skin lesion analysis towards melanoma detection challenge, and the other is the PH2 database. Experimental results showed that the proposed method outperformed other state-of-the-art algorithms on these two databases. Our method is general enough and only needs minimum pre- and post-processing, which allows its adoption in a variety of medical image segmentation tasks.
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    Publication Date: 2017-09-02
    Description: Describes the above-named upcoming conference event. May include topics to be covered or calls for papers.
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  • 71
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: These instructions give guidelines for preparing papers for this publication. Presents information for authors publishing in this journal.
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  • 72
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    Publication Date: 2017-09-02
    Description: While plane-wave imaging can improve the performance of power Doppler by enabling much longer ensembles than systems using focused beams, the long-ensemble averaging of the zero-lag autocorrelation R(0) estimates does not directly decrease the mean noise level, but only decreases its variance. Spatial variation of the noise due to the time-gain compensation and the received beamforming aperture ultimately limits sensitivity. In this paper, we demonstrate that the performance of power Doppler imaging can be improved by leveraging the higher lags of the autocorrelation [e.g., R(1), R(2),…] instead of the signal power (R(0)). As noise is completely uncorrelated from pulse-to-pulse while the flow signal remains correlated significantly longer, weak signals just above the noise floor can be made visible through the reduction of the noise floor. Finally, as coherence decreases proportionally with respect to velocity, we demonstrate how signal coherence can be targeted to separate flows of different velocities. For instance, we show how long-time-range coherence of microbubble contrast-enhanced flow specifically isolates slow capillary perfusion (as opposed to conduit flow).
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  • 73
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-02
    Description: Conventional Doppler ultrasound is useful for visualizing fast blood flow in large resolvable vessels. However, frame rate and tissue clutter caused by movement of the patient or sonographer make visualizing slow flow with ultrasound difficult. Patient and sonographer motion causes spectral broadening of the clutter signal, which limits ultrasound’s sensitivity to velocities greater than 5–10 mm/s for typical clinical imaging frequencies. To address this, we propose a clutter filtering technique that may increase the sensitivity of Doppler measurements to at least as low as 0.52 mm/s. The proposed technique uses plane wave imaging and an adaptive frequency and amplitude demodulation scheme to decrease the bandwidth of tissue clutter. To test the performance of the adaptive demodulation method at suppressing tissue clutter bandwidths due to sonographer hand motion alone, six volunteer subjects acquired data from a stationary phantom. Additionally, to test in vivo feasibility, arterial occlusion and muscle contraction studies were performed to assess the efficiency of the proposed filter at preserving signals from blood velocities 2 mm/s or greater at a 7.8 MHz center frequency. The hand motion study resulted in initial average bandwidths of 175 Hz (8.60mm/s), which were decreased to 10.5 Hz (0.52 mm/s) at −60 dB using our approach. The in vivo power Doppler studies resulted in 4.73 dB and 4.80 dB dynamic ranges of the blood flow with the proposed filter and 0.15 dB and 0.16 dB dynamic ranges of the blood flow with a conventional 50 Hz high-pass filter for the occlusion and contraction studies, respectively.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: This article introduces a new computer system architecture and how its benefits are tailored toward the cloud, fog, and ICT computing infrastructure. This new technology delivers a compute performance density 10 times higher than existing solutions while consuming only a quarter of the power and costing a third of the initial capital outlay for that performance. The capabilities of KMAX offers an attractive alternative to the PC platform, while opening new compute, storage, and networking capabilities.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-06
    Description: Associate EIC Barry Schneider looks at the history of computational physics and chemistry.
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  • 76
    Publication Date: 2017-09-06
    Description: To efficiently perform multiscale analysis of high-resolution, global, multiple-dimensional datasets, the authors have deployed the parallel ensemble empirical mode decomposition (PEEMD) package by implementing three-level parallelism into the ensemble empirical mode decomposition (EMD), achieving a scaled performance of 5,000 cores. In this study, they discuss the implementation of the PEEMD and its application for the analysis of Earth science data, including the solution of the Lorenz model, an idealized terrain-induced flow, and Hurricane Sandy.
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  • 77
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    Publication Date: 2017-09-06
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  • 78
    Publication Date: 2017-09-06
    Description: This article presents software for a satellite position and attitude control system based on mathematical modeling. The software is developed using Matlab for conceptual design; an added benefit is that it shortens design time and decrease design costs. Providing interactive modules for different actuators with various configurations and control algorithms makes this toolbox suitable for analyzing the effect of design parameters on satellite response and stability. Moreover, this toolbox contains adjustable modules for date and orbital parameters, which helps users improve their realization of satellite position effects on different matters such as eclipse, magnetic field, and satellite communication with ground station. Taking position data, the software computes disturbance torques and gives users the ability to analyze satellite attitude control performance. The software’s ability to show simulation results as a set of graphics and text windows makes it more user friendly.
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  • 79
    Publication Date: 2017-09-06
    Description: This article describes a pilot programming course in which high school students were introduced, through the visual programming language of live sequence charts (LSC), to a new paradigm termed scenario-based programming. The rationale underlying this course was teaching high school students a second, very different programming paradigm. Using LSC for this purpose has other advantages, such as exposing students to high-level programming, dealing with nondeterminism and concurrency, and referring to human-computer interaction (HCI) issues. This work also contributes to the discussion about guiding principles for curriculum development. It highlights an important principle: the educational objective of a course should include more than mere knowledge enhancement. A course should be examined and justified through its contribution to learning fundamental ideas and forming useful habits of mind.
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  • 80
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    Publication Date: 2017-09-20
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  • 81
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  • 82
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    Publication Date: 2017-09-20
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  • 83
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    Publication Date: 2017-09-20
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  • 84
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    Publication Date: 2017-09-23
    Description: Goal: Intracochlear sound pressure (ICSP) measurements are limited by the small dimensions of the human inner ear and the requirements imposed by the liquid medium. A robust intracochlear acoustic receiver (ICAR) for repeated use with a simple data acquisition system that provides the required high sensitivity and small dimensions does not yet exist. The work described in this report aims to fill this gap and presents a new microelectromechanical systems (MEMS) condenser microphone (CMIC)-based ICAR concept suitable for ICSP measurements in human temporal bones. Methods: The ICAR head consisted of a passive protective diaphragm (PD) sealing the MEMS CMIC against the liquid medium, enabling insertion into the inner ear. The components of the MEMS CMIC-based ICAR were expressed by a lumped element model (LEM) and compared to the performance of successfully fabricated ICARs. Results: Good agreement was achieved between the LEM and the measurements with different sizes of the PD. The ICSP measurements in a human cadaver temporal bone yielded data in agreement with the literature. Conclusion: Our results confirm that the presented MEMS CMIC-based ICAR is a promising technology for measuring ICSP in human temporal bones in the audible frequency range. Significance: A sensor for evaluation of the biomechanical hearing process by quantification of ICSP is presented. The concept has potential as an acoustic receiver in totally implantable cochlear implants.
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    Publication Date: 2017-09-23
    Description: We have developed a new headstage architecture as part of a smart experimental arena, known as the EnerCage-HC2 system, which automatically delivers stimulation and collects behavioral data over extended periods with minimal small animal subject handling or personnel intervention in a standard rodent homecage. Equipped with a four-coil inductive link, the EnerCage-HC2 system wirelessly powers the receiver (Rx) headstage, irrespective of the subject's location or head orientation, eliminating the need for tethering or carrying bulky batteries. On the transmitter (Tx) side, a driver coil, five high-quality (Q) factor segmented resonators at different heights and orientations, and a closed-loop Tx power controller create a homogeneous electromagnetic (EM) field within the homecage 3-D space, and compensate for drops in power transfer efficiency (PTE) due to Rx misalignments. The headstage is equipped with four small slanted resonators, each covering a range of head orientations with respect to the Tx resonators, which direct the EM field toward the load coil at the bottom of the headstage. Moreover, data links based on Wi-Fi, UART, and Bluetooth low energy are utilized to enables remote communication and control of the Rx. The PTE varies within 23.6%–33.3% and 6.7%–10.1% at headstage heights of 8 and 20 cm, respectively, while continuously delivering >40 mW to the Rx electronics even at 90° rotation. As a proof of EnerCage-HC2 functionality in vivo , a previously documented on-demand electrical stimulation of the globus pallidus, eliciting consistent head rotation, is demonstrated in three freely behaving rats.
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  • 86
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    Publication Date: 2017-09-23
    Description: Objective: Develop a reliable single-shot ${\rm{T}}_{{2}}$ mapping method with extra robustness to motion and the potential for real-time dynamic and quantitative MR imaging. Methods: A single-shot ${\rm{T}}_{{2}}$ mapping sequence was proposed based on spin-echo planar imaging acquisition scheme. Two overlapped echo signals with different ${\rm{T}}_{{2}}$ weighting were obtained simultaneously by using two small flip-angle excitation pulses and corresponding echo-shifting gradients. A detachment algorithm based on structure similarity constraint was proposed to separate the two echo signals. ${\rm{T}}_{{2}}$ mapping was obtained from the two separated echo signals. Results: The robustness and efficiency of the method were demonstrated through simulation, phantom experiments, and human brain measurements. Conclusion: Reliable ${\rm{T}}_{{2}}$ mapping can be obtained within milliseconds even under continuous head motion. Significance: Reliable ${\rm{T}}_{{2}}$ mapping was achieved with a single shot for the first time. The proposed method will facilitate real-time dynamic and quantitative MR imaging.
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    Publication Date: 2017-09-23
    Description: Objective: To provide a new approach to spectral quantification for magnetic resonance spectroscopic imaging (MRSI), incorporating both spatial and spectral priors. Methods: A novel signal model is proposed, which represents the spectral distributions of each molecule as a subspace and the entire spectrum as a union of subspaces. Based on this model, the spectral quantification can be solved in two steps: 1) subspace estimation based on the empirical distributions of the spectral parameters estimated using spectral priors; and 2) parameter estimation for the union-of-subspaces model incorporating spatial priors. Results: The proposed method has been evaluated using both simulated and experimental data, producing impressive results. Conclusion: The proposed union-of-subspaces representation of spatiospectral functions provides an effective computational framework for solving the MRSI spectral quantification problem with spatiospectral constraints. Significance: The proposed approach transforms how the MRSI spectral quantification problem is solved and enables efficient and effective use of spatiospectral priors to improve parameter estimation. The resulting algorithm is expected to be useful for a wide range of quantitative metabolic imaging studies using MRSI.
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-23
    Description: Objective: There is a need to monitor the heart rhythm in resuscitation to improve treatment quality. Resuscitation rhythms are categorized into: ventricular tachycardia (VT), ventricular fibrillation (VF), pulseless electrical activity (PEA), asystole (AS), and pulse-generating rhythm (PR). Manual annotation of rhythms is time-consuming and infeasible for large datasets. Our objective was to develop ECG-based algorithms for the retrospective and automatic classification of resuscitation cardiac rhythms. Methods: The dataset consisted of 1631 3-s ECG segments with clinical rhythm annotations, obtained from 298 out-of-hospital cardiac arrest patients. In total, 47 wavelet- and time-domain-based features were computed from the ECG. Features were selected using a wrapper-based feature selection architecture. Classifiers based on Bayesian decision theory, k-nearest neighbor, k-local hyperplane distance nearest neighbor, artificial neural network (ANN), and ensemble of decision trees were studied. Results: The best results were obtained for ANN classifier with Bayesian regularization backpropagation training algorithm with 14 features, which forms the proposed algorithm. The overall accuracy for the proposed algorithm was 78.5%. The sensitivities (and positive-predictive-values) for AS, PEA, PR, VF, and VT were 88.7% (91.0%), 68.9% (70.4%), 65.9% (69.0%), 86.2% (83.8%), and 78.8% (72.9%), respectively. Conclusions: The results demonstrate that it is possible to classify resuscitation cardiac rhythms automatically, but the accuracy for the organized rhythms (PEA and PR) is low. Significance: We have made an important step toward making classification of resuscitation rhythms more ef- icient in the sense of minimal feedback from human experts.
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  • 92
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-23
    Description: In the diagnosis of various cancers by analyzing histological images, automatic nuclear segmentation is an important step. However, nuclear segmentation is a difficult problem because of overlapping nuclei, inhomogeneous staining, and presence of noisy pixels and other tissue components. In this paper, we present an automatic technique for nuclear segmentation in skin histological images. The proposed technique first applies a bank of generalized Laplacian of Gaussian kernels to detect nuclear seeds. Based on the detected nuclear seeds, a multiscale radial line scanning method combined with dynamic programming is applied to extract a set of candidate nuclear boundaries. The gradient, intensity, and shape information are then integrated to determine the optimal boundary for each nucleus in the image. Nuclear overlap limitation is finally imposed based on a Dice coefficient measure such that the obtained nuclear contours do not severely intersect with each other. Experiments have been thoroughly performed on two datasets with H&E and Ki-67 stained images, which show that the proposed technique is superior to conventional schemes of nuclear segmentation.
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  • 93
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-23
    Description: Parkinson's disease (PD) is a chronic progressive disease caused by loss of dopaminergic neurons in the substantia nigra, degenerating the nervous system of a patient over time. Freezing of gait (FOG), which is a form of akinesia, is a symptom of PD. Meanwhile, recent studies show that the gait of PD patients experiencing FOG can be significantly improved by providing the regular visual or auditory patterns for the patients. In this paper, we propose a gait-aid system built upon smart glasses. Our system continuously monitors the gait and so on of a PD patient to detect FOG, and upon detection of FOG it projects visual patterns on the glasses as if the patterns were actually on the floor. Conducting experiments involving ten PD patients, we demonstrate that our system achieves the accuracy of 92.86 $\%$ in detecting FOG episodes and that it improves the gait speed and stride length of PD patients by 15.3 $\sim$ 37.2% and 18.7  $\sim$  31.7%, respectively.
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  • 94
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-23
    Description: This paper presents a novel strategy aiming to acquire an accurate and walking-speed-adaptive estimation of the gait phase through noncontact capacitive sensing and adaptive oscillators (AOs). The capacitive sensing system is designed with two sensing cuffs that can measure the leg muscle shape changes during walking. The system can be dressed above the clothes and free human skin from contacting to electrodes. In order to track the capacitance signals, the gait phase estimator is designed based on the AO dynamic system due to its ability of synchronizing with quasi-periodic signals. After the implementation of the whole system, we first evaluated the offline estimation performance by experiments with 12 healthy subjects walking on a treadmill with changing speeds. The strategy achieved an accurate and consistent gait phase estimation with only one channel of capacitance signal. The average root-mean-square errors in one stride were 0.19 rad (3.0% of one gait cycle) for constant walking speeds and 0.31 rad (4.9% of one gait cycle) for speed transitions even after the subjects rewore the sensing cuffs. We then validated our strategy in a real-time gait phase estimation task with three subjects walking with changing speeds. Our study indicates that the strategy based on capacitive sensing and AOs is a promising alternative for the control of exoskeleton/orthosis.
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  • 95
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-09-23
    Description: Since its introduction 25 years ago, Optical Coherence Tomography (OCT) has contributed tremendously to diagnostic and monitoring capabilities of pathologies in the field of ophthalmology. Despite rapid progress in hardware and software technology however, the price of OCT devices has remained high, limiting their use in private practice, and in screening examinations. In this paper, we present a slitlamp-integrated OCT device, built with off-the-shelf components, which can generate high-quality volumetric images of the posterior eye segment. To do so, we present a novel strategy for 3D image reconstruction in this challenging domain that allows us for state-of-the-art OCT volumes to be generated at fast speeds. The result is an OCT device that can match current systems in clinical practice, at a significantly lower cost.
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  • 96
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
    Description: Columnist Charles Day describes computing and the naval front during World War I.
    Print ISSN: 1521-9615
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  • 97
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
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  • 98
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-19
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  • 99
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    Institute of Electrical and Electronics Engineers (IEEE)
    Publication Date: 2017-08-23
    Description: Objective: Blind source separation (BSS) can be used to decompose complex electroencephalography (EEG) or magnetoencephalography data into simpler components based on statistical assumptions without using a physical model. Applications include brain–computer interfaces, artifact removal, and identifying parallel neural processes. We wish to address the issue of applying BSS to event-related responses, which is challenging because of nonstationary data. Methods: We introduce a new BSS approach called momentary-uncorrelated component analysis (MUCA), which is tailored for event-related multitrial data. The method is based on approximate joint diagonalization of multiple covariance matrices estimated from the data at separate latencies. We further show how to extend the methodology for autocovariance matrices and how to apply BSS methods suitable for piecewise stationary data to event-related responses. We compared several BSS approaches by using simulated EEG as well as measured somatosensory and transcranial magnetic stimulation (TMS) evoked EEG. Results: Among the compared methods, MUCA was the most tolerant one to noise, TMS artifacts, and other challenges in the data. With measured somatosensory data, over half of the estimated components were found to be similar by MUCA and independent component analysis. MUCA was also stable when tested with several input datasets. Conclusion: MUCA is based on simple assumptions, and the results suggest that MUCA is robust with nonideal data. Significance: Event-related responses and BSS are valuable and popular tools in neuroscience. Correctly designed BSS is an efficient way of identifying artifactual and neural processes from nonstationary event-related data.
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  • 100
    Publication Date: 2017-08-23
    Description: Objective: The use of a fully implanted first-generation prototype sensor/telemetry system is described for long-term monitoring of subcutaneous tissue glucose in a small cohort of people with diabetes. Methods: Sensors are based on a membrane containing immobilized glucose oxidase and catalase coupled to oxygen electrodes and a telemetry system, integrated as an implant. The devices remained implanted for up to 180 days, with signals transmitted every 2 min to external receivers. Results: The data include signal recordings from glucose clamps and spontaneous glucose excursions, matched, respectively, to reference blood glucose and finger-stick values. The sensor signals indicate dynamic tissue glucose, for which there is no independent standard, and a model describing the relationship between blood glucose and the signal is, therefore, included. The values of all model parameters have been estimated, including the permeability of adjacent tissues to glucose, and equated to conventional mass transfer parameters. As a group, the sensor calibration varied randomly at an average rate of −2.6%/week. Statistical correlation indicated strong association between the sensor signals and reference glucose values. Conclusion: Continuous long-term glucose monitoring in individuals with diabetes is feasible with this system. Significance: All therapies for diabetes are based on glucose control, and therefore, require glucose monitoring. This fully implanted long-term sensor/telemetry system may facilitate a new era of management of the disease.
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