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  • Mice
  • Models, Molecular
  • Springer  (3)
  • American Institute of Physics (AIP)
  • Nature Publishing Group (NPG)
  • 2010-2014
  • 1990-1994  (3)
  • 1990  (3)
Collection
Keywords
Publisher
Years
  • 2010-2014
  • 1990-1994  (3)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Energy expenditure and locomotor activity in mice selected for food intake adjusted for body weight (1990)
    Springer
    Theoretical and applied genetics 79 (1990), S. 131-136 
    Details
    ISSN: 1432-2242
    Keywords: Selection response ; Metabolic rate ; Inheritance of activity ; Mice
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary The aim of this study was to examine the differences in physical activity and their contribution to differences in energy utilization in mice, selected either high or low for food intake, adjusted for body weight, which show correlated responses in lean content and metabolic rate. Simultaneous measurements of fasting metabolic rate and activity were made in lines of mice selected at either: a young age, 4-to 6-week food intake corrected for 4-week body weight; or an older age, 8- to 10-week food intake corrected for mean weight at 8 and 10 weeks of age. Correlated response in metabolic rate was found to have been accompanied by changes in locomotor activity near the ages at selection in both sets of lines. Activity, however, accounted for only a small proportion of variation in fasting heat production, generally less than 5%, although a highly positive correlation (r=0.63) between the two traits was found. It was concluded that selection for food intake adjusted for body weight has led to correlated response in physical activity. In consequence, mice selected in the upward direction expend some of the excess energy intake rather than assimilating it as body mass and are, therefore, slightly leaner than their counterparts selected in the downward direction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00223799
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Selection response for litter size at birth and litter weight at weaning in the first parity in mice (1990)
    Springer
    Theoretical and applied genetics 80 (1990), S. 625-630 
    Details
    ISSN: 1432-2242
    Keywords: Selection ; Mice ; Litter size ; Litter weight ; Reproductive performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Five 60-pair lines of mice were selected for seven generations for the following criteria: number born alive (LSO), random selection of litters (LC), number born alive divided by the weight of the dam at 9 weeks (LSO/DWT), total litter weight weaned divided by the weight of the dam at 9 weeks (LWT/DWT), and weight of litter weaned (LWT). All traits were measured in the first parity only and litters were not standardized. Realized heritabilities for LSO, LWT, LSO/DWT, and LWT/ DWT were 0.10± 0.06, 0.11±0.07, 0.22 ± 0.04, and 0.22 ± 0.08, respectively. Selection response for the two ratio lines was due to correlated responses in the respective numerators, LSO and LWT, as DWT did not decrease. In terms of improving LWT, selection for LWT/ DWT was three times as effective as selection for LSO/ DWT.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00224221
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  • 3
    Electronic Resource
    Electronic Resource
    Selection for increased length of reproductive life in mice (1990)
    Springer
    Theoretical and applied genetics 79 (1990), S. 268-272 
    Details
    ISSN: 1432-2242
    Keywords: Mice ; Lifetime ; Performance ; Longevity ; Selection
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary An experiment was conducted in mice to examine whether selection can increase reproductive life and lifetime production of progeny. Mice in two lines with litter size standardized at birth and in two lines without standardization were pair-mated at 7 weeks of age and maintained as long as they produced litters up to 382 days. Progeny from the sixth litters were used to maintain the four selected lines, while progeny from the first litters were bred to maintain unselected control lines. Selected and control lines were compared at five and six generations of the selected lines. Contemporary comparisons revealed that the length of reproductive life and most lifetime production traits were significantly greater in the selected than in control lines. Realized heritability of the length of reproductive life ranged from 0.08 to 0.13. It was concluded that the length of reproductive life and lifetime production in mice can be increased by selection.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225962
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