ISSN:
1741-0444
Keywords:
Artificial heart
;
Biodegradation
;
Biomaterials
;
Blood compatibility tests in vitro and in vivo
;
Calcification
;
Protein adsorption
;
Toxicity
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Chemistry and Pharmacology
,
Medicine
Notes:
Abstract Synthetic materials used for medical prostheses and devices, mainly those which will come into contact with blood, have to provide for specific properties. Three in vitro blood-compatibility tests are presented; one is a screening method (m.t.e.g.) whose results show remarkable correlations to in vivo behaviour, the other two (Nosé-blood-chamber, protein adsorption) yield more basis information on synthetic surfaces. Aspects of toxicity and biodegradation should be included in the definition of ‘blood compatibility’. After preselection by in vitro tests, a material has to pass an in vivo examination in animal experiments (shunt, catheter, tube, test chamber) under haemodynamic conditions. Finally, devices or prostheses in their intended shape, such as the total artificial heart, are implanted in animals.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02443330
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