Publication Date:
2012-04-17
Description:
From its inception, tissue engineering has had three tenets: cells, biomaterial scaffolds and signaling molecules. Among the triad, cells are the center piece, because cells are the building blocks of tissues. For decades, cell therapies have focused on the procurement, manipulation and delivery of healthy cells for the treatment of diseases or trauma. Given the complexity and potential high cost of cell delivery, there is recent and surging interest to orchestrate endogenous cells for tissue regeneration. Biomaterial scaffolds are vital for many but not all, tissue-engineering applications and serve to accommodate or promote multiple cellular functions. Signaling molecules can be produced by transplanted cells or endogenous cells, or delivered specifically to regulate cell functions. This review highlights recent work in tissue engineering and cell therapies, with a focus on harnessing the capacity of endogenous cells as an alternative or adjunctive approach for tissue regeneration. Content Type Journal Article Category Review Pages 665-676 DOI 10.1007/s00441-012-1339-2 Authors Hemin Nie, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Chang Hun Lee, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Jiali Tan, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Chuanyong Lu, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Avital Mendelson, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Mo Chen, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Mildred C. Embree, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Kimi Kong, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Bhranti Shah, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Shuang Wang, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Shoko Cho, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Jeremy J. Mao, Tissue Engineering and Regenerative Medicine Laboratory (TERML), Columbia University Medical Center, 630 W. 168 St. – PH7E, New York, NY 10032, USA Journal Cell and Tissue Research Online ISSN 1432-0878 Print ISSN 0302-766X Journal Volume Volume 347 Journal Issue Volume 347, Number 3
Print ISSN:
0302-766X
Electronic ISSN:
1432-0878
Topics:
Biology
,
Medicine
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