Publikationsdatum:
1997-03-21
Beschreibung:
The "Spanish" influenza pandemic killed at least 20 million people in 1918-1919, making it the worst infectious pandemic in history. Understanding the origins of the 1918 virus and the basis for its exceptional virulence may aid in the prediction of future influenza pandemics. RNA from a victim of the 1918 pandemic was isolated from a formalin-fixed, paraffin-embedded, lung tissue sample. Nine fragments of viral RNA were sequenced from the coding regions of hemagglutinin, neuraminidase, nucleoprotein, matrix protein 1, and matrix protein 2. The sequences are consistent with a novel H1N1 influenza A virus that belongs to the subgroup of strains that infect humans and swine, not the avian subgroup.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Taubenberger, J K -- Reid, A H -- Krafft, A E -- Bijwaard, K E -- Fanning, T G -- New York, N.Y. -- Science. 1997 Mar 21;275(5307):1793-6.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Division of Molecular Pathology, Department of Cellular Pathology, Armed Forces Institute of Pathology, Washington DC 20306-6000, USA. taubenbe@email.afip.osd.mil〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/9065404" target="_blank"〉PubMed〈/a〉
Schlagwort(e):
Algorithms
;
Base Sequence
;
*Genes, Viral
;
Hemagglutinin Glycoproteins, Influenza Virus/genetics
;
History, 20th Century
;
Humans
;
Influenza A virus/classification/*genetics/pathogenicity
;
Influenza, Human/history/*virology
;
Lung/virology
;
Molecular Sequence Data
;
Neuraminidase/genetics
;
Nucleoproteins/genetics
;
Phylogeny
;
Polymerase Chain Reaction
;
RNA, Viral/*genetics
;
*RNA-Binding Proteins
;
Viral Core Proteins/genetics
;
Viral Matrix Proteins/genetics
;
Virulence
Print ISSN:
0036-8075
Digitale ISSN:
1095-9203
Thema:
Biologie
,
Chemie und Pharmazie
,
Informatik
,
Medizin
,
Allgemeine Naturwissenschaft
,
Physik
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