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  • Articles  (1,266)
  • Springer Nature  (1,266)
  • American Association for the Advancement of Science
  • American Meteorological Society
  • American Physical Society (APS)
  • Blackwell Publishing Ltd
  • 2010-2014  (1,266)
  • 2000-2004
  • 1995-1999
  • 1955-1959
  • 1935-1939
  • 1930-1934
  • 2012  (394)
  • 2010  (872)
  • 2003
  • 1984
  • 1983
  • 1959
  • 1932
  • Nature Precedings  (111)
  • 180185
  • Natural Sciences in General  (1,266)
  • Geosciences  (1,266)
  • Architecture, Civil Engineering, Surveying
Collection
  • Articles  (1,266)
Source
Publisher
  • Springer Nature  (1,266)
  • American Association for the Advancement of Science
  • American Meteorological Society
  • American Physical Society (APS)
  • Blackwell Publishing Ltd
Years
  • 2010-2014  (1,266)
  • 2000-2004
  • 1995-1999
  • 1955-1959
  • 1935-1939
    • +
Year
  • 2012  (394)
  • 2010  (872)
  • 2003
  • 1984
  • 1983
    • +
Journal
Topic
  • 1
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    Schizophrenia is a TH2 dominant autoimmune disease possibly against acetylcholine receptors of CNS (2012)
    Springer Nature
    Details
    Publication Date: 2012-03-13
    Description: Schizophrenia is a very common psychiatric disorder. However, its etiology and pathogenesis is still unknown. Current theory saying that neurotransmitter imbalance such as serotonin or dopamine only provides limited effectiveness in schizophrenia treatment by drugs changing serotonin and dopamine concentration. Despite of such treatment, majority of schizophrenia patients still have very poor prognosis. Thus, the neurotransmitter imbalance theory is not correct. Here, I propose that schizophrenia is actually a TH2 dominant autoimmune disorder. The candidate of autoantigen could be acetylcholine receptors of CNS. My theory can explain the positive as well as negative symptoms of schizophrenia. By microarray analysis of PBMCS, one-tenth of the total 519 significantly expressed genes are immune-related genes. Among them, TH2 related genes are significantly up-regulated including IL-4, histidine decarboxylase, aldehyde dehydrogenase, CCR9, IgE Fc receptor, GATA2, serotonin receptor, phospholipase A2, and prostaglandin D2 synthase. Besides, TH1 and TH17 related genes are down-regulated including CXCL5, cathepsin C, and neutrophil related S100 binding proteins. The new theory sheds a light to better control this detrimental illness. Anti-inflammatory agents could be used to manage schizophrenia in the near future.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 2
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    Translational neuroscience requires better design and analysis of preclinical studies (2012)
    Springer Nature
    Details
    Publication Date: 2012-03-15
    Description: Animal models are often used to obtain a better understanding of psychiatric, neurodegenerative, and neurodevelopmental disorders. Despite many years of research, these models have not led to many novel therapies or treatments. Translating results between species will always be difficult, and it is argued that inappropriate statistical analyses, failure to identify the experimental unit, lack of random assignment to treatment conditions, and unblinded assessment of outcomes contribute to the low rate of translating preclinical in vivo studies into successful therapies. It is known that these shortcomings can generate biased estimates, too many false positives and false negatives, and unreproducible results. These issues have been raised repeatedly, but have largely gone unheeded by scientists. Two recommendations are made to improve the situation.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 3
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    Mobile Image Ratiometry for the Detection of Botrytis cinerea (Gray Mold) (2012)
    Springer Nature
    Details
    Publication Date: 2012-03-15
    Description: Mobile Platform Informatics (MPI) and Smartphone Informatics (SPI) methods like Mobile Image Ratiometry (MIR) are potentially transformative point-of-use instantaneous analysis tools that are useful across a variety of industries. In agriculture, MIR-compatible immuno test strips allow early detection of a number of biotic stressors before devastating crop losses occur. Here we describe a low-cost and easy-to-use Smartphone and/or tablet-based protocol (Mobile Assay Inc., www.mobileassay.com) for the detection and on-sight instantaneous analysis of B. cinerea, a fungus that causes significant damage to a variety of plants and flowers. Early detection and tracking of the B. cinerea fungus before the visible gray mold appears has the potential to increase agricultural productivity especially in the developing world.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 4
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    Inter-Tunneling Mechanism of Colliding Population Waves (2012)
    Springer Nature
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    Publication Date: 2012-03-16
    Description: Here we show a new interaction mechanism of colliding population waves. It provides a stable coexistence of two similar but different species competing for the same limiting resource during their asexual propagation in a limited homogeneous environment under constant conditions. The revealed mechanism opens new opportunities in conservation biology.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 5
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    The phyogenetic principles of mma: A hypothetical biostratigraphic model (2012)
    Springer Nature
    Details
    Publication Date: 2012-03-16
    Description: Two erectoid hominids from Sarstedt prompted a detailed examination of the course of the impressions of the Arteria meningea media and their characteristics within the line of hominidae.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
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  • 6
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    Genomic Replikin Counts of Infectious Salmon Anemia Virus (ISAV) in Canada Exceed the Counts in Lethal Outbreaks in Norway, Chile, and Scotland. Real-Time Tracking of the Evolution of the ISAV Genome and the Resultant Replikins Solid Phase ISAV Vacci (2012)
    Springer Nature
    Details
    Publication Date: 2012-03-16
    Description: Genomic Replikin CountsTM of Infectious Salmon Anemia Virus (ISAV) in Canada Exceed the Counts in Lethal Outbreaks in Norway, Chile, and Scotland. Real-Time Tracking of the Evolution of the ISAV Genome and the Resultant Replikins Solid Phase ISAV Vaccine Make ISAV Pandemic Prevention Possible.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 7
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    HTRIdb: an open-access database for experimentally verified human transcriptional regulation interactions (2012)
    Springer Nature
    Details
    Publication Date: 2012-03-16
    Description: Background: The modeling of interactions among transcription factors (TFs) and their respective target genes (TGs) into transcriptional regulatory networks is important for the complete understanding of regulation of biological processes. In the case of human TF-TG interactions, there is no database at present that explicitly provides such information even though many databases containing human TF-TG interaction data have been available. In an effort to provide researchers with a repository of TF-TG interactions from which such interactions can be directly extracted, we present here the Human Transcriptional Regulation Interactions database (HTRIdb).Description: The HTRIdb is an open-access database of experimentally validated interactions among human TFs and their TGs. HTRIdb can be searched via a user-friendly web interface and the retrieved TF-TG interactions data and the associated protein-protein interactions can be downloaded or interactively visualized as a network using the Cytoscape Web software. Moreover, users can improve the database quality by uploading their own interactions and indicating inconsistencies in the data. So far, HTRIdb has been populated with 283 TFs that regulate 11886 genes, totaling 18160 TF-TG interactions. HTRIdb is freely available at http://www.lbbc.ibb.unesp.br/htri.Conclusions: HTRIdb is a powerful user-friendly tool from which human experimentally validated TF-TG interactions can be easily extracted and used to construct transcriptional regulation interaction networks enabling researchers to decipher the regulation of biological processes.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 8
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    AntEpiSeeker2.0: extending epistasis detection to epistasis-associated pathway inference using ant colony optimization (2012)
    Springer Nature
    Details
    Publication Date: 2012-03-16
    Description: Genome-wide association studies (GWAS) have become a standard method for finding genetic variations that contribute to common, complex diseases. Recently, it is suggested that these diseases may be caused by epistatic interactions of multiple genetic variations. Although tens of software tools have been developed for epistasis detection, few are able to infer pathway importance from the identified epistatic interactions. AntEpiSeeker is originally an algorithm for detecting epistatic interactions in case-control studies, using a two-stage ant colony optimization (ACO) algorithm. We have developed AntEpiSeeker2.0, which extends the AntEpiSeeker algorithm to inference of epistasis-associated pathways, based on a natural use of the ACO pheromones. By looking at pheromone distribution across pathways, epistasis-associated pathways can be easily identified. The effectiveness of AntEpiSeeker2.0 in inferring epistasis-associated pathways is demonstrated through a simulation study and a real data application. AntEpiSeeker 2.0 was designed to provide efficient inference of epistasis-associated pathways based on ant colony optimization and is freely available at http://lambchop.ads.uga.edu/antepiseeker2/.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 9
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    Agriculture: Nanotechnology’s Green Field (2012)
    Springer Nature
    Details
    Publication Date: 2012-02-22
    Description: Natural agricultural production functions in open system, where energy and matter are exchanged freely between geosphere (especially pedosphere), biosphere, and atmosphere. The self regulation of biophysical processes in these spheres is crucial for global sustainability. However, modern farming practices have stressed the system to the extent that damaged C, N, and P cycles are threatening catastrophic consequences. High food-wastage coupled with high food price, high soil fertility zones but low crop productivity, and highly productive irrigated farming marred with ecological disasters are examples of global paradoxes associated with modern farming. High incidence of pesticide residues in soil and water bodies, low use efficiency of agricultural inputs, vulnerability to climate, and low conversion of energy by crops leaving high amount of residues and their subsequent burden on environment, and hunger and malnutrition in many parts of the world are threatening civilizations to crumble. Nanotechnology promises to break these vicious cycles, because technology is based on applying exact amounts of inputs for use by the crops, and only when they are required. Some of the examples are: nanofabricating nutrient ions to improve nutrient use efficiency, targeted use of nano-pesticides, holding of water and then releasing it at the time of crop need by nps, forecasting and elimination of diseases, packaging of food to improve shelf-life, protecting food during storage, DNA nanotechnology, smart treatment delivery systems, bioanalytical nanosensors, bioselective surfaces, nanobioprocessing, protection of the environment by the reduction and conversion of agricultural materials into valuable products, design and development of new nanocatalysts to convert vegetable oils into biobased fuels and biodegradable industrial solvents, and controlled ecological life support system.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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  • 10
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    A call for disruptive innovation in science publishing with a new open data-sharing platform for the life sciences (2012)
    Springer Nature
    Details
    Publication Date: 2012-04-05
    Description: “A disruptive innovation is an innovation that helps create a new market and value network, and eventually goes on to disrupt an existing market and value network (over a few years or decades), displacing an earlier technology. The term is used in business and technology literature to describe innovations that improve a product or service in ways that the market does not expect.” -WikipediaOn April 3rd, 2012 Nature Precedings, Nature Publishing Group’s experiment in free pre-print publishing was shut down and no longer accepts submissions. According to the Nature Precedings website it was created in 2007 as “a place for researchers to share documents, including presentations, posters, white papers, technical papers, supplementary findings, and non-peer-reviewed manuscripts.” It was designed to “provide a rapid means for scientists to share preliminary findings, disseminate emerging results, solicit community feedback, and claim priority over discoveries.” It was designed in a way to “make such material easy to archive, share and cite.” Now that Nature Precedings is no more, a new disruptive open data-sharing platform (ODSP) for the life sciences is needed. Based, in part, by the model Nature Precedings established. Here I propose 5 qualities of an ideal ODSP and outline 10 benefits (see Table 1) to scientists for embracing such a potentially disruptive model.
    Electronic ISSN: 1756-0357
    Topics: Natural Sciences in General , Geosciences , Physics , Chemistry and Pharmacology , Biology , Medicine
    Published by Springer Nature
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