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A critical role for NF2 and the Hippo pathway in branching morphogenesis (2016)

Antoine Reginensi; Leonie Enderle; Alex Gregorieff; Randy L. Johnson; Jeffrey L. Wrana; Helen McNeill

Springer Nature

In: Nature Communications

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Publication Date: 2016-08-04

Description: Article Branching morphogenesis is essential for the formation of most epithelial organs. Here, the authors show that Neurofibromatosis 2 (NF2), the Hippo pathway kinases LATS1 and LATS2, and the transcriptional co-activators YAP and TAZ control tip identity, RET signalling and branching morphogenesis in the mouse kidney. Nature Communications doi: 10.1038/ncomms12309 Authors: Antoine Reginensi, Leonie Enderle, Alex Gregorieff, Randy L. Johnson, Jeffrey L. Wrana, Helen McNeill

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Patterns and functional implications of rare germline variants across 12 cancer types (2015)

Charles Lu; Mingchao Xie; Michael C. Wendl; Jiayin Wang; Michael D. McLellan; Mark D. M. Leiserson; Kuan-lin Huang; Matthew A. Wyczalkowski; Reyka Jayasinghe; Tapahsama Banerjee; Jie Ning; Piyush Tripathi; Qunyuan Zhang; Beifang Niu; Kai Ye; Heather K. Schmidt; Robert S. Fulton; Joshua F. McMichael; Prag Batra; Cyriac Kandoth; Maheetha Bharadwaj; Daniel C. Koboldt; Christopher A. Miller; Krishna L. Kanchi; James M. Eldred; David E. Larson; John S. Welch; Ming You; Bradley A. Ozenberger; Ramaswamy Govindan; Matthew J. Walter; Matthew J. Ellis; Elaine R. Mardis; Timothy A. Graubert; John F. Dipersio; Timothy J. Ley; Richard K. Wilson; Paul J. Goodfellow; Benjamin J. Raphael; Feng Chen; Kimberly J. Johnson; Jeffrey D. Parvin; Li Ding

Springer Nature

In: Nature Communications

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Publication Date: 2015-12-24

Description: Article Published sequencing data sets of cancer samples could be used to identify genetic variants associated with the risk of developing cancer. Here, Lu et al . analyse over 4,000 tumour-normal pairs to reveal variable frequencies of inherited susceptibilities across 12 cancer types and find enrichment of functionally validated missense variants of unknown significance. Nature Communications doi: 10.1038/ncomms10086 Authors: Charles Lu, Mingchao Xie, Michael C. Wendl, Jiayin Wang, Michael D. McLellan, Mark D. M. Leiserson, Kuan-lin Huang, Matthew A. Wyczalkowski, Reyka Jayasinghe, Tapahsama Banerjee, Jie Ning, Piyush Tripathi, Qunyuan Zhang, Beifang Niu, Kai Ye, Heather K. Schmidt, Robert S. Fulton, Joshua F. McMichael, Prag Batra, Cyriac Kandoth, Maheetha Bharadwaj, Daniel C. Koboldt, Christopher A. Miller, Krishna L. Kanchi, James M. Eldred, David E. Larson, John S. Welch, Ming You, Bradley A. Ozenberger, Ramaswamy Govindan, Matthew J. Walter, Matthew J. Ellis, Elaine R. Mardis, Timothy A. Graubert, John F. Dipersio, Timothy J. Ley, Richard K. Wilson, Paul J. Goodfellow, Benjamin J. Raphael, Feng Chen, Kimberly J. Johnson, Jeffrey D. Parvin, Li Ding

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Natural selection favoring more transmissible HIV detected in United States molecular transmission network (2019)

Wertheim, Joel O. ; Oster, Alexandra M. ; Switzer, William M. ; [et al.]

Springer Nature

In: Nature Communications. 2019; 10(1): 5788. Published 2019 Dec 01. doi: 10.1038/s41467-019-13723-z.

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Publication Date: 2019-12-01

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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Structure of the human marker of self 5-transmembrane receptor CD47 (2021)

Fenalti, Gustavo ; Villanueva, Nicolas ; Griffith, Mark ; [et al.]

Springer Nature

In: Nature Communications. 2021; 12(1): 5218. Published 2021 Sep 01. doi: 10.1038/s41467-021-25475-w.

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Publication Date: 2021-09-01

Description: CD47 is the only 5-transmembrane (5-TM) spanning receptor of the immune system. Its extracellular domain (ECD) is a cell surface marker of self that binds SIRPα and inhibits macrophage phagocytosis, and cancer immuno-therapy approaches in clinical trials are focused on blocking CD47/SIRPα interaction. We present the crystal structure of full length CD47 bound to the function-blocking antibody B6H12. CD47 ECD is tethered to the TM domain via a six-residue peptide linker (114RVVSWF119) that forms an extended loop (SWF loop), with the fundamental role of inserting the side chains of W118 and F119 into the core of CD47 extracellular loop region (ECLR). Using hydrogen-deuterium exchange and molecular dynamics simulations we show that CD47’s ECLR architecture, comprised of two extracellular loops and the SWF loop, creates a molecular environment stabilizing the ECD for presentation on the cell surface. These findings provide insights into CD47 immune recognition, signaling and therapeutic intervention.

Electronic ISSN: 2041-1723

Topics: Biology , Chemistry and Pharmacology , Natural Sciences in General , Physics

Published by Springer Nature

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