ALBERT

Beschreibung: Sepsis has no proven pharmacologic treatment other than appropriate antibiotic agents, fluids, vasopressors as needed, and possibly corticosteroids. It is generally initiated mainly by the simultaneous recognition by various components of the innate immune system of either pathogen-associated molecular patterns (PAMPs) or damage-associated molecular patterns (DAMPs). In the current study, we employed the murine cecal ligation and puncture (CLP) model for sepsis to evaluate the effect of post-CLP infusion of apoptotic cells (Allocetra-OTS) on a CLP severe sepsis model. Cardiovascular evaluation, acute kidney injury (AKI), acute liver injury (ALI), and hematological and metabolic function were evaluated. Cytokine and chemokine profiles were measured by Multiplex ELISA and mitochondrial function, and glycolysis by Seahorse. The Murine Sepsis Score (MSS) was used for disease severity definition. CLP mice had low blood pressure, poor cardiac output, and lung dysfunction, as well as AKI, ALI, and thrombocytopenia, which correlated with the MSS and corresponded to a cytokine/chemokine storm. Apoptotic cell administration markedly improved the cytokine and chemokine storm and restored the impaired mitochondrial and glycolytic function in white blood cells leading to increased survival, from 6 to 60% (P 

Beschreibung: Dia1, which belongs to the diaphanous-related formin family, influences a variety of cellular processes through straight actin elongation activity. Recently, novel DIA1 mutants such as p.R1213X (p.R1204X) and p.A265S, have been reported to cause an autosomal dominant sensorineural hearing loss (DFNA1). Additionally, active DIA1 mutants induce progressive hearing loss in a gain-of-function manner. However, the subcellular localization and pathological function of DIA1(R1213X/R1204X) remains unknown. In the present study, we demonstrated the localization of endogenous Dia1 and the constitutively active DIA1 mutant in the cochlea, using transgenic mice expressing FLAG-tagged DIA1(R1204X) (DIA1-TG). Endogenous Dia1 and the DIA1 mutant were regionally expressed at the organ of Corti and the spiral ganglion from early life; alongside cochlear maturation, they became localized at the apical junctional complexes (AJCs) between hair cells (HCs) and supporting cells (SCs). To investigate HC vulnerability in the DIA1-TG mice, we exposed 4-week-old mice to moderate noise, which induced temporary threshold shifts with cochlear synaptopathy and ultrastructural changes in stereocilia 4 weeks post noise exposure. Furthermore, we established a knock-in (KI) mouse line expressing AcGFP-tagged DIA1(R1213X) (DIA1-KI) and confirmed mutant localization at AJCs and the tips of stereocilia in HCs. In MDCKAcGFP-DIA1(R1213X) cells with stable expression of AcGFP-DIA1(R1213X), AcGFP-DIA1(R1213X) revealed marked localization at microvilli on the apical surface of cells and decreased localization at cell-cell junctions. The DIA1-TG mice demonstrated hazy and ruffled circumferential actin belts at AJCs and abnormal stereocilia accompanied with HC loss at 5 months of age. In conclusion, Dia1 plays a pivotal role in the development and maintenance of AJCs and stereocilia, ensuring cochlear and HC integrity. Subclinical/latent vulnerability of HCs may be the cause of progressive hearing loss in DFNA1 patients, thus suggesting new therapeutic targets for preventing HC degeneration and progressive hearing loss associated with DFNA1.

Beschreibung: Breast cancer is considered to be the most prevalent cancer in women worldwide, and metastasis is the primary cause of death. Protease-activated receptor 1 (PAR1) is a GPCR family member involved in the invasive and metastatic processes of cancer cells. However, the functions and underlying mechanisms of PAR1 in breast cancer remain unclear. In this study, we found that PAR1 is highly expressed in high invasive breast cancer cells, and predicts poor prognosis in ER-negative and high-grade breast cancer patients. Mechanistically, Twist transcriptionally induces PAR1 expression, leading to inhibition of Hippo pathway and activation of YAP/TAZ; Inhibition of PAR1 suppresses YAP/TAZ-induced epithelial-mesenchymal transition (EMT), invasion, migration, cancer stem cell (CSC)-like properties, tumor growth and metastasis of breast cancer cells in vitro and in vivo. These findings suggest that PAR1 acts as a direct transcriptionally target of Twist, can promote EMT, tumorigenicity and metastasis by controlling the Hippo pathway; this may lead to a potential therapeutic target for treating invasive breast cancer.

Beschreibung: The outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in December 2019. As similar cases rapidly emerged around the world1–3, the World Health Organization (WHO) declared a public health emergency of international concern on January 30, 2020 and pronounced the rapidly spreading coronavirus outbreak as a pandemic on March 11, 20204. The virus has reached almost all countries of the globe. As of June 3, 2020, the accumulated confirmed cases reached 6,479,405 with more than 383,013 deaths worldwide. The urgent and emergency care of COVID-19 patients calls for effective drugs, in addition to the beneficial effects of remdesivir5, to control the disease and halt the pandemic.

Beschreibung: Renal cell carcinoma (RCC) is one of the most frequently observed malignant tumours in the urinary system and targeted drug resistance is quite common in RCC. Long noncoding RNA SNHG12 (lncRNA SNHG12) has emerged as a key molecule in numerous human cancers, but its functions in renal cell carcinoma (RCC) sunitinib resistance remain unclear. In this study, we found SNHG12 was highly expressed in RCC tissues and in sunitinib-resistant RCC cells and was associated with a poor clinical prognosis. SNHG12 promoted RCC proliferation, migration, invasion and sunitinib resistance via CDCA3 in vitro. Mechanically, SNHG12 bound to SP1 and prevented the ubiquitylation-dependent proteolysis of SP1. Stabilised SP1 bound to a specific region in the promoter of CDCA3 and increased CDCA3 expression. Furthermore, in vivo experiments showed that SNHG12 increased tumour growth and that knocking down SNHG12 could reverse RCC sunitinib resistance. Our study revealed that the lncRNA SNHG12/SP1/CDCA3 axis promoted RCC progression and sunitinib resistance, which could provide a new therapeutic target for sunitinib-resistant RCC.

Beschreibung: PD-L1 is overexpressed in tumor cells and contributes to cancer immunoevasion. However, the role of the tumor cell-intrinsic PD-L1 in cancers remains unknown. Here we show that PD-L1 regulates lung cancer growth and progression by targeting the WIP and β-catenin signaling. Overexpression of PD-L1 promotes tumor cell growth, migration and invasion in lung cancer cells, whereas PD-L1 knockdown has the opposite effects. We have also identified WIP as a new downstream target of PD-L1 in lung cancer. PD-L1 positively modulates the expression of WIP. Knockdown of WIP also inhibits cell viability and colony formation, whereas PD-L1 overexpression can reverse this inhibition effects. In addition, PD-L1 can upregulate β-catenin by inhibiting its degradation through PI3K/Akt signaling pathway. Moreover, we show that in lung cancer cells β-catenin can bind to the WIP promoter and activate its transcription, which can be promoted by PD-L1 overexpression. The in vivo experiments in a human lung cancer mouse model have also confirmed the PD-L1-mediated promotion of tumor growth and progression through activating the WIP and β-catenin pathways. Furthermore, we demonstrate that PD-L1 expression is positively correlated with WIP in tumor tissues of human adenocarcinoma patients and the high expression of PD-L1 and WIP predicts poor prognosis. Collectively, our results provide new insights into understanding the pro-tumorigenic role of PD-L1 and its regulatory mechanism on WIP in lung cancer, and suggest that the PD-L1/Akt/β-catenin/WIP signaling axis may be a potential therapeutic target for lung cancers.

Beschreibung: Ferroptosis is an iron- and lipotoxicity-dependent form of regulated cell death (RCD). It is morphologically and biochemically distinct from characteristics of other cell death. This modality has been intensively investigated in recent years due to its involvement in a wide array of pathologies, including cancer, neurodegenerative diseases, and acute kidney injury. Dysregulation of ferroptosis has also been linked to various liver diseases and its modification may provide a hopeful and attractive therapeutic concept. Indeed, targeting ferroptosis may prevent the pathophysiological progression of several liver diseases, such as hemochromatosis, nonalcoholic steatohepatitis, and ethanol-induced liver injury. On the contrary, enhancing ferroptosis may promote sorafenib-induced ferroptosis and pave the way for combination therapy in hepatocellular carcinoma. Glutathione peroxidase 4 (GPx4) and system xc− have been identified as key players to mediate ferroptosis pathway. More recently diverse signaling pathways have also been observed. The connection between ferroptosis and other forms of RCD is intricate and compelling, where discoveries in this field advance our understanding of cell survival and fate. In this review, we summarize the central molecular machinery of ferroptosis, describe the role of ferroptosis in non-cancer hepatic disease conditions and discuss the potential to manipulate ferroptosis as a therapeutic strategy.

Beschreibung: Phosphoribosylaminoimidazole carboxylase, phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS), an essential enzyme involved in de novo purine biosynthesis, is connected with formation of various tumors. However, the specific biological roles and related mechanisms of PAICS in gastric cancer (GC) remain unclear. In the present study, we identified for the first time that PAICS was significantly upregulated in GC and high expression of PAICS was correlated with poor prognosis of patients with GC. In addition, knockdown of PAICS significantly induced cell apoptosis, and inhibited GC cell growth both in vitro and in vivo. Mechanistic studies first found that PAICS was engaged in DNA damage response, and knockdown of PAICS in GC cell lines induced DNA damage and impaired DNA damage repair efficiency. Further explorations revealed that PAICS interacted with histone deacetylase HDAC1 and HDAC2, and PAICS deficiency decreased the expression of DAD51 and inhibited its recruitment to DNA damage sites by impairing HDAC1/2 deacetylase activity, eventually preventing DNA damage repair. Consistently, PAICS deficiency enhanced the sensitivity of GC cells to DNA damage agent, cisplatin (CDDP), both in vitro and in vivo. Altogether, our findings demonstrate that PAICS plays an oncogenic role in GC, which act as a novel diagnosis and prognostic biomarker for patients with GC.

Beschreibung: Cancer stem cell (CSC) is a challenge in the therapy of triple-negative breast cancer (TNBC). Intratumoral hypoxia is a common feature of solid tumor. Hypoxia may contribute to the maintenance of CSC, resulting in a poor efficacy of traditional treatment and recurrence of TNBC cases. However, the underlying molecular mechanism involved in hypoxia-induced CSC stemness maintenance remains unclear. Here, we report that hypoxia stimulated DNA double-strand breaks independent of ATM kinase activation (called oxidized ATM in this paper) play a crucial role in TNBC mammosphere formation and stemness maintenance by governing a specific energy metabolism reprogramming (EMR). Oxidized ATM up-regulates GLUT1, PKM2, and PDHa expressions to enhance the uptake of glucose and production of pyruvate rather than lactate products, which facilitates glycolytic flux to mitochondrial pyruvate and citrate, thus resulting in accumulation of cytoplasmic acetyl-CoA instead of the tricarboxylic acid (TCA) cycle by regulating ATP-citrate lyase (ACLY) activity. Our findings unravel a novel model of TNBC-CSC glucose metabolism and its functional role in maintenance of hypoxic TNBC-CSC stemness. This work may help us to develop new therapeutic strategies for TNBC treatment.

Beschreibung: Dysregulation of RKIP and NRF2 has been widely involved in the therapy resistance of multiple malignances, however, their relation and the corresponding mechanisms, especially in radiation response, have not been elucidated. In this study, we revealed that RKIP could negatively regulate the expression of NRF2 in nasopharyngeal carcinoma (NPC) cells. Depletion or ectopic expression of NRF2 countered the pro- or anti- radioresistant effects of RKIP knockdown or overexpression on NPC cells, respectively, both in vitro and in vivo. Furthermore, our results indicated that NQO1 was positively regulated by NRF2 and served as the downstream effector of RKIP/NRF2 axis in regulation of NPC radioresistance. Mechanistically, miR-450b-5p, being positively regulated by RKIP in NPC cells, could sensitize NPC cells to irradiation by directly targeting and suppressing the level of NRF2. Besides, we analyzed the level of aforementioned molecules in NPC tissues. The results indicated that RKIP was significantly downregulated, NRF2 and NQO1 were notably upregulated in NPC tissues compared with in normal nasopharyngeal mucosa (NNM) tissues. Furthermore, RKIP and miR-450b-5p were remarkably lower, yet NRF2 and NQO1 were notably higher, in radioresistant NPC tissues relative to in radiosensitive NPC tissues. Consistent with the pattern in NPC cells, the RKIP/miR-450b-5p/NRF2/NQO1 axis was significantly correlated in NPC tissues. Downregulation of RKIP and miR-450b-5p, and upregulation of NRF2 and NQO1, positively correlated to malignant pathological parameters such as primary T stage, Lymph node (N) metastasis, and TNM stage. Finally, RKIP and miR-450b-5p served as favorable prognostic indicators, and NRF2 and NQO1 acted as unfavorable prognostic biomarkers in patients with NPC. Collectively, our outcomes reveal that RKIP downregulation promotes radioresistance of NPC by downregulating miR-450b-5p and subsequently upregulating and activating NRF2 and NQO1, highlighting RKIP/miR-450b-5p/NRF2/NQO1 axis as a potential therapeutic target for improving the radiosensitivity of NPC.

Beschreibung: Chop deficiency prevents UUO-induced renal fibrosis by attenuating fibrotic signals originated from Hmgb1/TLR4/NFκB/IL-1β signaling Cell Death and Disease 6, e1847 (August 2015). doi:10.1038/cddis.2015.206 Authors: M Zhang, Y Guo, H Fu, S Hu, J Pan, Y Wang, J Cheng, J Song, Q Yu, S Zhang, J-F Xu, G Pei, X Xiang, P Yang & C-Y Wang

Beschreibung: Protein tyrosine kinase 6 promotes ERBB2-induced mammary gland tumorigenesis in the mouse Cell Death and Disease 6, e1848 (August 2015). doi:10.1038/cddis.2015.210 Authors: M Peng, S M Ball-Kell & A L Tyner

Beschreibung: Tyr1068-phosphorylated epidermal growth factor receptor (EGFR) predicts cancer stem cell targeting by erlotinib in preclinical models of wild-type EGFR lung cancer Cell Death and Disease 6, e1850 (August 2015). doi:10.1038/cddis.2015.217 Authors: G Sette, V Salvati, M Mottolese, P Visca, E Gallo, K Fecchi, E Pilozzi, E Duranti, E Policicchio, M Tartaglia, M Milella, R De Maria & A Eramo

Beschreibung: Assessment of p53 and ATM functionality in chronic lymphocytic leukemia by multiplex ligation-dependent probe amplification Cell Death and Disease 6, e1852 (August 2015). doi:10.1038/cddis.2015.223 Authors: G D te Raa, P D Moerland, A C Leeksma, I A Derks, H Yigittop, N Laddach, M Loden-van Straaten, V Navrkalova, M Trbusek, D M Luijks, T Zenz, A Skowronska, M Hoogendoorn, T Stankovic, M H van Oers, E Eldering & A P Kater

Beschreibung: Silencing NFBD1/MDC1 enhances the radiosensitivity of human nasopharyngeal cancer CNE1 cells and results in tumor growth inhibition Cell Death and Disease 6, e1849 (August 2015). doi:10.1038/cddis.2015.214 Authors: Z Wang, Q Zeng, T Chen, K Liao, Y Bu, S Hong & G Hu

Beschreibung: Syncytial apoptosis signaling network induced by the HIV-1 envelope glycoprotein complex: an overview Cell Death and Disease 6, e1846 (August 2015). doi:10.1038/cddis.2015.204 Authors: R Nardacci, J-L Perfettini, L Grieco, D Thieffry, G Kroemer & M Piacentini

Beschreibung: Hexokinase 2 controls cellular stress response through localization of an RNA-binding protein Cell Death and Disease 6, e1837 (August 2015). doi:10.1038/cddis.2015.209 Authors: L Courteau, J Crasto, G Hassanzadeh, S D Baird, J Hodgins, U Liwak-Muir, G Fung, H Luo, D F Stojdl, R A Screaton & M Holcik

Beschreibung: DRP1 inhibition rescues retinal ganglion cells and their axons by preserving mitochondrial integrity in a mouse model of glaucoma Cell Death and Disease 6, e1839 (August 2015). doi:10.1038/cddis.2015.180 Authors: K-Y Kim, G A Perkins, M S Shim, E Bushong, N Alcasid, S Ju, M H Ellisman, R N Weinreb & W-K Ju

Beschreibung: NSC-87877 inhibits DUSP26 function in neuroblastoma resulting in p53-mediated apoptosis Cell Death and Disease 6, e1841 (August 2015). doi:10.1038/cddis.2015.207 Authors: Y Shi, I T Ma, R H Patel, X Shang, Z Chen, Y Zhao, J Cheng, Y Fan, Y Rojas, E Barbieri, Z Chen, Y Yu, J Jin, E S Kim, J M Shohet, S A Vasudevan & J Yang

Beschreibung: Exploring the role of MKK7 in excitotoxicity and cerebral ischemia: a novel pharmacological strategy against brain injury Cell Death and Disease 6, e1854 (August 2015). doi:10.1038/cddis.2015.226 Authors: A Vercelli, S Biggi, A Sclip, I E Repetto, S Cimini, F Falleroni, S Tomasi, R Monti, N Tonna, F Morelli, V Grande, M Stravalaci, E Biasini, O Marin, F Bianco, D di Marino & T Borsello

Beschreibung: MiR-26a functions oppositely in osteogenic differentiation of BMSCs and ADSCs depending on distinct activation and roles of Wnt and BMP signaling pathway Cell Death and Disease 6, e1851 (August 2015). doi:10.1038/cddis.2015.221 Authors: X Su, L Liao, Y Shuai, H Jing, S Liu, H Zhou, Y Liu & Y Jin

Beschreibung: Scaffolding protein Homer1a protects against NMDA-induced neuronal injury Cell Death and Disease 6, e1843 (August 2015). doi:10.1038/cddis.2015.216 Authors: Y Wang, W Rao, C Zhang, C Zhang, M-d Liu, F Han, L-b Yao, H Han, P Luo, N Su & Z Fei

Beschreibung: p53- and p73-independent activation of TIGAR expression in vivo Cell Death and Disease 6, e1842 (August 2015). doi:10.1038/cddis.2015.205 Authors: P Lee, A K Hock, K H Vousden & E C Cheung

Beschreibung: Thiazolides promote apoptosis in colorectal tumor cells via MAP kinase-induced Bim and Puma activation Cell Death and Disease 6, e1778 (June 2015). doi:10.1038/cddis.2015.137 Authors: A Brockmann, A Bluwstein, A Kögel, S May, A Marx, M P Tschan & T Brunner

Beschreibung: Activation of transient receptor potential vanilloid 4 induces apoptosis in hippocampus through downregulating PI3K/Akt and upregulating p38 MAPK signaling pathways Cell Death and Disease 6, e1775 (June 2015). doi:10.1038/cddis.2015.146 Authors: P Jie, Z Hong, Y Tian, Y Li, L Lin, L Zhou, Y Du, L Chen & L Chen

Beschreibung: Chloride transporter KCC2-dependent neuroprotection depends on the N-terminal protein domain Cell Death and Disease 6, e1776 (June 2015). doi:10.1038/cddis.2015.127 Authors: A Winkelmann, M Semtner & J C Meier

Beschreibung: Brain death and marginal grafts in liver transplantation Cell Death and Disease 6, e1777 (June 2015). doi:10.1038/cddis.2015.147 Authors: M B Jiménez-Castro, J Gracia-Sancho & C Peralta

Beschreibung: MicroRNA-587 antagonizes 5-FU-induced apoptosis and confers drug resistance by regulating PPP2R1B expression in colorectal cancer Cell Death and Disease 6, e1845 (August 2015). doi:10.1038/cddis.2015.200 Authors: Y Zhang, G Talmon & J Wang

Beschreibung: AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages Cell Death and Disease 6, e1856 (August 2015). doi:10.1038/cddis.2015.211 Authors: E Six, C Lagresle-Peyrou, S Susini, C De Chappedelaine, N Sigrist, H Sadek, M Chouteau, N Cagnard, M Fontenay, O Hermine, C Chomienne, P Reynier, A Fischer, I André-Schmutz, N Gueguen & M Cavazzana

Beschreibung: Radiation-induced gamma-synuclein in regards to DC function Cell Death and Disease 6, e1883 (September 2015). doi:10.1038/cddis.2015.253 Authors: J-Y Song & D-S Lim

Beschreibung: Preventing ototoxic hearing loss by inhibiting histone deacetylases Cell Death and Disease 6, e1882 (September 2015). doi:10.1038/cddis.2015.252 Authors: W S Layman & J Zuo

Beschreibung: ER stress induces NLRP3 inflammasome activation and hepatocyte death Cell Death and Disease 6, e1879 (September 2015). doi:10.1038/cddis.2015.248 Authors: C Lebeaupin, E Proics, C H D de Bieville, D Rousseau, S Bonnafous, S Patouraux, G Adam, V J Lavallard, C Rovere, O Le Thuc, M C Saint-Paul, R Anty, A S Schneck, A Iannelli, J Gugenheim, A Tran, P Gual & B Bailly-Maitre

Beschreibung: A cascade of protein aggregation bombards mitochondria for neurodegeneration and apoptosis under WWOX deficiency Cell Death and Disease 6, e1881 (September 2015). doi:10.1038/cddis.2015.251 Authors: C I Sze, Y M Kuo, L J Hsu, T F Fu, M F Chiang, J Y Chang & N S Chang

Beschreibung: Autophagy regulates hepatocyte identity and epithelial-to-mesenchymal and mesenchymal-to-epithelial transitions promoting Snail degradation Cell Death and Disease 6, e1880 (September 2015). doi:10.1038/cddis.2015.249 Authors: G Grassi, G Di Caprio, L Santangelo, G M Fimia, A M Cozzolino, M Komatsu, G Ippolito, M Tripodi & T Alonzi

Beschreibung: Absence of RIPK3 predicts necroptosis resistance in malignant melanoma Cell Death and Disease 6, e1884 (September 2015). doi:10.1038/cddis.2015.240 Authors: P Geserick, J Wang, R Schilling, S Horn, P A Harris, J Bertin, P J Gough, M Feoktistova & M Leverkus

Beschreibung: MicroRNA-22 inhibits tumor growth and metastasis in gastric cancer by directly targeting MMP14 and Snail Cell Death and Disease 6, e2000 (November 2015). doi:10.1038/cddis.2015.297 Authors: Q-F Zuo, L-Y Cao, T Yu, L Gong, L-N Wang, Y-L Zhao, B Xiao & Q-M Zou

Beschreibung: In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins Cell Death and Disease 6, e1996 (November 2015). doi:10.1038/cddis.2015.341 Authors: D Senft, A Weber, F Saathoff, C Berking, M V Heppt, C Kammerbauer, S Rothenfusser, S Kellner, Z Kurgyis, R Besch & G Häcker

Beschreibung: A novel cyclic helix B peptide inhibits dendritic cell maturation during amelioration of acute kidney graft rejection through Jak-2/STAT3/SOCS1 Cell Death and Disease 6, e1993 (November 2015). doi:10.1038/cddis.2015.338 Authors: C Yang, Y Zhang, J Wang, L Li, L Wang, M Hu, M Xu, Y Long, R Rong & T Zhu

Beschreibung: Elevated α-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinson's patient-derived induced pluripotent stem cells Cell Death and Disease 6, e1994 (November 2015). doi:10.1038/cddis.2015.318 Authors: L M A Oliveira, L J Falomir-Lockhart, M G Botelho, K-H Lin, P Wales, J C Koch, E Gerhardt, H Taschenberger, T F Outeiro, P Lingor, B Schüle, D J Arndt-Jovin & T M Jovin

Beschreibung: P2X7 receptor activity regulation: the role of CD44 proteoglycan GAG chains Cell Death and Disease 6, e1997 (November 2015). doi:10.1038/cddis.2015.340 Authors: G E D D Moura, S V Lucena, M A Lima, F D Nascimento, T F Gesteira, H B Nader, E J Paredes-Gamero & I L S Tersariol

Beschreibung: DED or alive: assembly and regulation of the death effector domain complexes Cell Death and Disease 6, e1866 (August 2015). doi:10.1038/cddis.2015.213 Authors: J S Riley, A Malik, C Holohan & D B Longley

Beschreibung: Activation of RARα induces autophagy in SKBR3 breast cancer cells and depletion of key autophagy genes enhances ATRA toxicity Cell Death and Disease 6, e1861 (August 2015). doi:10.1038/cddis.2015.236 Authors: D Brigger, A M Schläfli, E Garattini & M P Tschan

Beschreibung: Co-receptors are dispensable for tethering receptor-mediated phagocytosis of apoptotic cells Cell Death and Disease 6, e1772 (May 2015). doi:10.1038/cddis.2015.140 Authors: B Park, J Lee, H Moon, G Lee, D-H Lee, J Hoon Cho & D Park

Beschreibung: CD59 signaling and membrane pores drive Syk-dependent erythrocyte necroptosis Cell Death and Disease 6, e1773 (May 2015). doi:10.1038/cddis.2015.135 Authors: T J LaRocca, E A Stivison, T Mal-Sarkar, T A Hooven, E A Hod, S L Spitalnik & A J Ratner

Beschreibung: Dual induction of apoptotic and autophagic cell death by targeting survivin in head neck squamous cell carcinoma Cell Death and Disease 6, e1771 (May 2015). doi:10.1038/cddis.2015.139 Authors: L Zhang, W Zhang, Y-F Wang, B Liu, W-F Zhang, Y-F Zhao, A B Kulkarni & Z-J Sun

Beschreibung: Cross talk between EBV and telomerase: the role of TERT and NOTCH2 in the switch of latent/lytic cycle of the virus Cell Death and Disease 6, e1774 (May 2015). doi:10.1038/cddis.2015.145 Authors: S Giunco, A Celeghin, K Gianesin, R Dolcetti, S Indraccolo & A De Rossi

Beschreibung: PML nuclear body disruption impairs DNA double-strand break sensing and repair in APL Cell Death and Disease 7, e2308 (July 2016). doi:10.1038/cddis.2016.115 Authors: A di Masi, D Cilli, F Berardinelli, A Talarico, I Pallavicini, R Pennisi, S Leone, A Antoccia, N I Noguera, F Lo-Coco, P Ascenzi, S Minucci & C Nervi

Beschreibung: Ferroptosis is induced following siramesine and lapatinib treatment of breast cancer cells Cell Death and Disease 7, e2307 (July 2016). doi:10.1038/cddis.2016.208 Authors: S Ma, E S Henson, Y Chen & S B Gibson

Beschreibung: Granzyme M has a critical role in providing innate immune protection in ulcerative colitis Cell Death and Disease 7, e2302 (July 2016). doi:10.1038/cddis.2016.215 Authors: F Souza-Fonseca-Guimaraes, Y Krasnova, T Putoczki, K Miles, K P MacDonald, L Town, W Shi, G C Gobe, L McDade, L A Mielke, H Tye, S L Masters, G T Belz, N D Huntington, G Radford-Smith & M J Smyth

Beschreibung: Proton pump inhibitors protect mice from acute systemic inflammation and induce long-term cross-tolerance Cell Death and Disease 7, e2304 (July 2016). doi:10.1038/cddis.2016.218 Authors: E Balza, P Piccioli, S Carta, R Lavieri, M Gattorno, C Semino, P Castellani & A Rubartelli

Beschreibung: The route to solve the interplay between inflammation, angiogenesis and anti-cancer immune response Cell Death and Disease 7, e2299 (July 2016). doi:10.1038/cddis.2016.211 Authors: C Botta, G Misso, E C Martino, L Pirtoli, M G Cusi, P Tassone, P Tagliaferri, M Caraglia & P Correale

Beschreibung: TWEAK favors phosphate-induced calcification of vascular smooth muscle cells through canonical and non-canonical activation of NFκB Cell Death and Disease 7, e2305 (July 2016). doi:10.1038/cddis.2016.220 Authors: L Hénaut, A B Sanz, D Martin-Sanchez, S Carrasco, R Villa-Bellosta, G Aldamiz-Echevarria, Z A Massy, M D Sanchez-Nino & A Ortiz

Beschreibung: Activation of salt-inducible kinase 2 promotes the viability of peritoneal mesothelial cells exposed to stress of peritoneal dialysis Cell Death and Disease 7, e2298 (July 2016). doi:10.1038/cddis.2016.79 Authors: H-H Wang, C-Y Lin, S-H Su, C-T Chuang, Y-L Chang, T-Y Lee, S-C Lee & C-J Chang

Beschreibung: Tankyrase inhibition aggravates kidney injury in the absence of CD2AP Cell Death and Disease 7, e2302 (July 2016). doi:10.1038/cddis.2016.217 Authors: S Kuusela, H Wang, A A Wasik, H Suleiman & S Lehtonen

Beschreibung: WASH has a critical role in NK cell cytotoxicity through Lck-mediated phosphorylation Cell Death and Disease 7, e2301 (July 2016). doi:10.1038/cddis.2016.212 Authors: L Huang, P Zhu, P Xia & Z Fan

Beschreibung: DNA-PK-mediated phosphorylation of EZH2 regulates the DNA damage-induced apoptosis to maintain T-cell genomic integrity Cell Death and Disease 7, e2316 (July 2016). doi:10.1038/cddis.2016.198 Authors: Y Wang, H Sun, J Wang, H Wang, L Meng, C Xu, M Jin, B Wang, Y Zhang, Y Zhang & T Zhu

Beschreibung: Cereblon negatively regulates TLR4 signaling through the attenuation of ubiquitination of TRAF6 Cell Death and Disease 7, e2313 (July 2016). doi:10.1038/cddis.2016.226 Authors: Yoon Min, Sae Mi Wi, Jung-Ah Kang, Taewoo Yang, Chul-Seung Park, Sung-Gyoo Park, Sungkwon Chung, Jae-Hyuck Shim, Eunyoung Chun & Ki-Young Lee

Beschreibung: Exosome-mediated delivery of miR-9 induces cancer-associated fibroblast-like properties in human breast fibroblasts Cell Death and Disease 7, e2312 (July 2016). doi:10.1038/cddis.2016.224 Authors: S Baroni, S Romero-Cordoba, I Plantamura, M Dugo, E D’Ippolito, A Cataldo, G Cosentino, V Angeloni, A Rossini, M G Daidone & M V Iorio

Beschreibung: Inhibitor of apoptosis protein expression in glioblastomas and their in vitro and in vivo targeting by SMAC mimetic GDC-0152 Cell Death and Disease 7, e2325 (August 2016). doi:10.1038/cddis.2016.214 Authors: A Tchoghandjian, A Soubéran, E Tabouret, C Colin, E Denicolaï, C Jiguet-Jiglaire, A El-Battari, C Villard, N Baeza-Kallee & D Figarella-Branger

Beschreibung: TMEM166/EVA1A interacts with ATG16L1 and induces autophagosome formation and cell death Cell Death and Disease 7, e2323 (August 2016). doi:10.1038/cddis.2016.230 Authors: Jia Hu, Ge Li, Liujing Qu, Ning Li, Wei Liu, Dan xia, Beiqi Hongdu, Xin Lin, Chentong Xu, Yaxin Lou, Qihua He, Dalong Ma & Yingyu Chen

Beschreibung: TLR and NLRP3 inflammasome-dependent innate immune responses to tumor-derived autophagosomes (DRibbles) Cell Death and Disease 7, e2322 (August 2016). doi:10.1038/cddis.2016.206 Authors: Y Xing, R Cao & H-M Hu

Beschreibung: Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway Cell Death and Disease 7, e2324 (August 2016). doi:10.1038/cddis.2016.227 Authors: Hsiang-Cheng Chi, Shen-Liang Chen, Yi-Hung Cheng, Tzu-Kang Lin, Chung-Ying Tsai, Ming-Ming Tsai, Yang-Hsiang Lin, Ya-Hui Huang & Kwang-Huei Lin

Beschreibung: Transgelin is a TGFβ-inducible gene that regulates osteoblastic and adipogenic differentiation of human skeletal stem cells through actin cytoskeleston organization Cell Death and Disease 7, e2321 (August 2016). doi:10.1038/cddis.2016.196 Authors: M Elsafadi, M Manikandan, R A Dawud, N M Alajez, R Hamam, M Alfayez, M Kassem, A Aldahmash & A Mahmood

Beschreibung: Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4 Cell Death and Disease 7, e2277 (June 2016). doi:10.1038/cddis.2016.181 Authors: J Xiao, Y Pan, X H Li, X Y Yang, Y L Feng, H H Tan, L Jiang, J Feng & X Y Yu

Beschreibung: Critical role of astrocytic interleukin-17 A in post-stroke survival and neuronal differentiation of neural precursor cells in adult mice Cell Death and Disease 7, e2273 (June 2016). doi:10.1038/cddis.2015.284 Authors: Y Lin, J-C Zhang, C-Y Yao, Y Wu, A F Abdelgawad, S-L Yao & S-Y Yuan

Beschreibung: The APRIL paradox in normal versus malignant B cell biology Cell Death and Disease 7, e2276 (June 2016). doi:10.1038/cddis.2016.183 Authors: M H A van Attekum, A P Kater & E Eldering

Beschreibung: Junctophilin 3 expresses in pancreatic beta cells and is required for glucose-stimulated insulin secretion Cell Death and Disease 7, e2275 (June 2016). doi:10.1038/cddis.2016.179 Authors: L Li, Z-F Pan, X Huang, B-W Wu, T Li, M-X Kang, R-S Ge, X-Y Hu, Y-H Zhang, L-J Ge, D-Y Zhu, Y-L Wu & Y-J Lou

Beschreibung: Engineered adenovirus fiber shaft fusion homotrimer of soluble TRAIL with enhanced stability and antitumor activity Cell Death and Disease 7, e2274 (June 2016). doi:10.1038/cddis.2016.177 Authors: J Yan, L Wang, Z Wang, Z Wang, B Wang, R Zhu, J Bi, J Wu, H Zhang, H Wu, B Yu, W Kong & X Yu

Beschreibung: STAT3 modulates β-cell cycling in injured mouse pancreas and protects against DNA damage Cell Death and Disease 7, e2272 (June 2016). doi:10.1038/cddis.2016.171 Authors: S De Groef, D Renmans, Y Cai, G Leuckx, S Roels, W Staels, G Gradwohl, L Baeyens, Y Heremans, G A Martens, N De Leu, M Sojoodi, M Van de Casteele & H Heimberg

Beschreibung: Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease Cell Death and Disease 7, e2271 (June 2016). doi:10.1038/cddis.2016.173 Authors: I Celardo, A C Costa, S Lehmann, C Jones, N Wood, N E Mencacci, G R Mallucci, S H Y Loh & L M Martins

Beschreibung: NUPR1, a new target in liver cancer: implication in controlling cell growth, migration, invasion and sorafenib resistance Cell Death and Disease 7, e2269 (June 2016). doi:10.1038/cddis.2016.175 Authors: M R Emma, J L Iovanna, D Bachvarov, R Puleio, G R Loria, G Augello, S Candido, M Libra, A Gulino, V Cancila, J A McCubrey, G Montalto & M Cervello

Beschreibung: Towards maximising information extraction from rodent models of ocular disease Cell Death and Disease 7, e2270 (June 2016). doi:10.1038/cddis.2016.174 Authors: B M Davis, L Guo, J Brenton, L Langley, E M Normando & M F Cordeiro

Beschreibung: The emerging role of Toll-like receptor 4 in myocardial inflammation Cell Death and Disease 7, e2234 (May 2016). doi:10.1038/cddis.2016.140 Authors: Y Yang, J Lv, S Jiang, Z Ma, D Wang, W Hu, C Deng, C Fan, S Di, Y Sun & W Yi

Beschreibung: Mechanical stimulation orchestrates the osteogenic differentiation of human bone marrow stromal cells by regulating HDAC1 Cell Death and Disease 7, e2221 (May 2016). doi:10.1038/cddis.2016.112 Authors: J Wang, C D Wang, N Zhang, W X Tong, Y F Zhang, S Z Shan, X L Zhang & Q F Li

Beschreibung: GADD34 suppresses lipopolysaccharide-induced sepsis and tissue injury through the regulation of macrophage activation Cell Death and Disease 7, e2219 (May 2016). doi:10.1038/cddis.2016.116 Authors: S Ito, Y Tanaka, R Oshino, S Okado, M Hori & K-I Isobe

Beschreibung: The four and a half LIM domains 2 (FHL2) regulates ovarian granulosa cell tumor progression via controlling AKT1 transcription Cell Death and Disease 7, e2297 (July 2016). doi:10.1038/cddis.2016.207 Authors: G Hua, C He, X Lv, L Fan, C Wang, S W Remmenga, K J Rodabaugh, L Yang, S M Lele, P Yang, A R Karpf, J S Davis & C Wang

Beschreibung: Double-edged-sword effect of IL-1β on the osteogenesis of periodontal ligament stem cells via crosstalk between the NF-κB, MAPK and BMP/Smad signaling pathways Cell Death and Disease 7, e2296 (July 2016). doi:10.1038/cddis.2016.204 Authors: C-y Mao, Y-g Wang, X Zhang, X-y Zheng, T-t Tang & E-y Lu

Beschreibung: GPRC5A is a potential oncogene in pancreatic ductal adenocarcinoma cells that is upregulated by gemcitabine with help from HuR Cell Death and Disease 7, e2294 (July 2016). doi:10.1038/cddis.2016.169 Authors: H Zhou, A G Telonis, Y Jing, N L Xia, L Biederman, M Jimbo, F Blanco, E Londin, J R Brody & I Rigoutsos

Beschreibung: The pancreatitis-associated protein VMP1, a key regulator of inducible autophagy, promotes KrasG12D-mediated pancreatic cancer initiation Cell Death and Disease 7, e2295 (July 2016). doi:10.1038/cddis.2016.202 Authors: C Loncle, M I Molejon, S Lac, J I Tellechea, G Lomberk, L Gramatica, M F Fernandez Zapico, N Dusetti, R Urrutia & J L Iovanna