Publication Date:
2011-02-02
Description:
We agree that some cancers may primarily have a polyclonal origin that results in genetically heterogeneous tumors. Retracing the Evolutionary Steps in Cancer (RESIC), as currently implemented (1), is not applicable to these cases. Depending on the source of heterogeneity, we are considering several refinements to our algorithm. Should this heterogeneity arise from interactions between separate cell populations, as in the polyclonal colorectal cancer example by Parsons (2), we will remove the independence assumption of cell niches. However, such modification requires information on the mechanisms, frequency, and strength of interniche interactions, which is not currently available. Without this knowledge, any...
Keywords:
Letters
Print ISSN:
0027-8424
Electronic ISSN:
1091-6490
Topics:
Biology
,
Medicine
,
Natural Sciences in General
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