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  • bic Book Industry Communication::M Medicine  (249)
  • Cell & Developmental Biology
  • Inorganic Chemistry
  • English  (249)
  • 2020-2024  (249)
  • 2023  (249)
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  • 2020-2024  (249)
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  • 1
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    On the Inequality of Lives (2023)
    Collège de France
    Details
    Publication Date: 2023-12-06
    Description: There is, on the one hand, life that flows from a beginning to an end, and, on the other hand, life that constitutes human singularity because it can be recounted. We may term them “biological life” and “biographical life”. Life expectancy measures the length of the former; a life story relates the richness of the latter. Only by acknowledging both can the inequality of lives be comprehended. They should be conceived of as being both distinct and connected: distinct, because the paradox of French women shows that a long life is no guarantee of a good life; connected, because the experience of African-American men stands as a reminder that a devalued life is a damaged life. This also raises the question of refugees and migrants.
    Keywords: society ; health ; public health ; sociology ; social science ; anthropology ; inequality ; life ; social inequality ; life expectancy ; lives ; inequity ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFH Illness & addiction: social aspects ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFJ Social discrimination & inequality ; bic Book Industry Communication::M Medicine
    Language: English
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  • 2
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    Pediatric Cancers (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: Childhood cancer or pediatric cancer is one of the leading causes of death among children. Treatment strategies for pediatric cancers include chemotherapy, surgery, radiation, and stem cell transplantation. These therapeutic regimens are well known to develop highly toxic and long-lasting side-effects including secondary cancers in the future lifespan of pediatric patients. Despite these intensive therapeutic regimens, cancer may still relapse as refractory and metastatic cancer. Therefore, further understanding the causes of different pediatric cancers, mechanisms of drug-resistance, and causes of relapse and metastasis is required for developing and advancing less toxic and more effective therapeutic strategies for pediatric cancers. Recent advancements in immunotherapies and targeted therapeutic approaches using pharmacological inhibitors are one step in this direction.In this Special Issue of Cancers, authors contributed original research and review articles focusing on different aspects of pediatric cancer development, causes, maintenance, and therapeutic strategies. The collected articles in this Special Issue will further enhance our knowledge and understanding of pediatric cancers and drive the development of novel therapeutic strategies.
    Keywords: infections ; cancer ; children ; bacteremia ; pneumonia ; sarcoma ; solid tumor ; outcome ; KI67 ; EZRIN ; 18F-FDG PET/CT ; random forest ; radiogenomics ; chemotherapy response ; metastasis ; serine-threonine kinase receptor-associated protein ; neuroblastoma ; CRISPR-Cas9 ; metronomic chemotherapy ; maintenance therapy ; high-risk ; Ewing sarcoma ; RNA-binding proteins ; regulation network ; prognosis prediction ; risk model ; melanotic neuroectodermal tumor of infancy ; inoperable ; metastatic ; recurrent ; chemotherapy ; adjuvant ; neoadjuvant ; systemic treatment ; childhood malignant bone tumors ; survivorship ; late effects ; somatic disease ; cohort study ; rhabdomyosarcoma ; targeted therapies ; cell surface proteomics ; B7-H3 ; stress ; allostasis ; stress regulatory pathways ; stress dysregulation ; stress reactivity ; early life stress ; childhood cancer ; cytotoxic cancer treatment ; interventions ; ependymoma ; risk stratification ; molecular group ; prognosis ; nephroblastoma ; clinical malformations ; cancer predisposition syndromes ; tumor surveillance ; n/a ; DSRCT ; EWSR1-WT1 ; preclinical model ; in vitro model ; pediatric cancer ; pediatric ; brain ; tumor ; medulloblastoma ; glioma ; natural products ; drug discovery ; fungal secondary metabolites ; soil microbes ; RH30 ; RD ; EZH2 ; epigenetic ; EPZ005687 ; DZNep ; AdOx ; malignant rhabdoid tumor ; hepatoblastoma ; small cell undifferentiated (SCUD) hepatoblastoma ; SMARCB1 ; INI1 ; pediatric liver tumors ; drug repurposing ; PI3K pathway ; epigenetics ; Fimepinostat ; LPAR1 ; LPA ; tumor metastasis ; bioinformatics analysis ; ulixertinib ; ERK inhibition ; combination therapy ; c-Myc/N-Myc ; cell differentiation ; ATRA ; SOX4 ; diffuse intrinsic pontine glioma ; immunotherapy ; immune microenvironment ; immune checkpoint inhibitor ; vaccine ; oncolytic virus ; myeloid sarcoma ; chloroma ; acute myeloid leukemia ; pediatric cancers ; VIPN ; DIC ; MDR ; drug transporters ; childhood acute leukemia ; early complication ; hyperleukocytosis ; risk factor ; survival outcome ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 3
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    Gastrointestinal Malignancies: Screening, Diagnosis, and Treatment (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: Gastrointestinal (GI) malignancies represent a diverse spectrum of cancers with notable global incidence and prevalence. The comprehensive care of individuals affected by these malignancies is a multifaceted endeavor involving the collaboration of various medical disciplines. The nonspecific clinical manifestations of GI cancers often present a formidable diagnostic challenge to primary care providers, resulting in diagnostic delays. Subsequently, the treatment regimens, once initiated, are often demanding and prolonged, and profoundly impact the patients' overall quality of life. Given the intricate involvement of the digestive system, nutritional concerns are pervasive among these patients, influencing both their quality of life and survival. Despite these considerable challenges, the evolving landscape of treatment modalities has yielded improved outcomes, enabling a greater number of patients to achieve remission or extended survival. It is now imperative that we delve deeper into understanding the unique needs of this patient population and refine the care delivery pathways through enhanced diagnostic approaches, treatment strategies, and holistic support, and ultimately enhance the overall value of care provided to individuals afflicted by GI malignancies.
    Keywords: HCV ; esophageal cancer ; male ; interferon ; mortality ; colorectal cancer ; gynecologic cancer ; retrospective cohort study ; colonoscopy screening ; gastric cancer ; ascites ; postoperative follow-up ; gastrectomy ; endoscopic submucosal dissection ; early gastric cancer ; type 2 diabetes mellitus ; glycemic control ; insulin resistance ; hepatocellular carcinoma ; annexin A2 ; prognostic marker ; survival outcome ; biliary tract cancer ; circulating tumor cell ; vimentin ; diagnosis ; prognosis ; gastric xanthelasma ; synchronous/metachronous gastric cancer ; genetic alteration ; predicting marker ; interval cancer ; screening ; endoscopy ; national cancer screening program ; c-Myc ; genetic linkage analysis ; cigarette smoking ; survival ; CRC ; CCL2 ; CCL4 ; CCL15 ; diagnostic utility ; gastrointestinal malignancies ; cancer survivorship ; calcium carbonate ; hypercalcemia ; cancer outcomes ; bic Book Industry Communication::M Medicine
    Language: English
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  • 4
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    Advances in Postoperative Pain Management and Chronic Postoperative Pain (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: This Special Issue delves deeply into the intricate distinctions between acute and chronic pain. Crucially, chronic pain is more than a mere by-product of sensory input; it entails the activation of a complex brain network intertwined with biopsychosocial factors. As such, its management emerges as a formidable clinical challenge. Within the scope of this Special Issue, focused attention is given to postoperative pain (POP) and chronic postsurgical pain (CPSP). POP, characterized by its predictability, intensity, and short duration, contrasts starkly with the potentially persistent and troublesome nature of CPSP, which can endure for over three months if not adequately addressed. The prevention of CPSP takes on paramount importance, with regional anesthesia techniques emerging as promising tools for intervention. The pivotal role of multimodal analgesia and combined therapeutic strategies is underscored. The Special Issue also delves into the intriguing realm of gender differences in pain perception, advocating for further research to illuminate these disparities. Risk factors contributing to the development of chronic pain following surgery are meticulously identified. Lastly, this Special Issue explores the potential of new technologies in the field of telemedicine and artificial intelligence to optimize care delivery, opening new avenues for enhanced patient outcomes and treatment strategies.
    Keywords: Postoperative pain ; Chronic postoperative pain ; Pain mechanisms ; Postoperative pain management ; Physiopathology of chronic postoperative pain ; Opioids ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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  • 5
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    Cell Therapy, Bispecific Antibodies and other Immunotherapies Against Cancer (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: This Special Issue in Cancers is focused on cell therapy, bispecific antibodies, and other immunotherapies against cancer. It includes reports on cell therapies such as CAR-NK cell therapies, and bispecific antibodies against multiple myeloma and B cell lymphoma. Immunotherapies against solid tumors include TGF-beta-PDL-1 fusion protein and EpCAM-CD3 bispecific antibody generated with mRNA-lipid nanoparticles (LNP) against colorectal tumors. The clinical studies ongoing with bi- and tri-specific T cell engager antibodies against solid tumors and advantages versus cell therapies are discussed. This Special Issue highlights novel approaches to cell therapies, bispecific antibodies, vaccines, and immunotherapies that will be interesting for cancer cell researchers, biologists, and oncologists.
    Keywords: cell therapy ; bispecific antibody ; chimeric antigen receptor ; cancer ; immunotherapy ; vaccine ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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  • 6
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    Recent Advances in Understanding of the Role of Synuclein Family Members in Health and Disease (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: In this Special Issue, we have compiled data and opinions from leading scientists to demonstrate the recent advances in the study of function and dysfunction of synucleins. These proteins are involved in multiple normal and pathological molecular processes and consequently have various effects on cell biology of the nervous system. Three members of the synuclein family share many structural properties and have an overlapping pattern of expression and intracellular distribution in the developing and adult nervous system, which point to functional redundancy within the family. However, each synuclein has its own functions which are not shared with the two other family members, and there are certain cellular mechanisms and pathways in which these functions could be antagonistic rather than synergistic.
    Keywords: prenatal alcohol exposure ; synucleins ; alcohol consumption ; free-choice ; hippocampus ; midbrain ; mRNA expression ; α-synuclein ; rats ; dopaminergic neuron ; MPTP ; knockout mice ; Parkinson’s disease ; alpha-synuclein ; SH-SY5Y ; hiPSCs ; organoid ; aggregation ; synucleinopathy ; blood–brain barrier ; microglia ; astrocytes ; overexpression ; mutation ; Lewy body ; synucleinopathies ; multiple system atrophy ; dementia with Lewy bodies ; deep brain stimulation ; focused ultrasound ; gene therapy ; surgical techniques ; dopamine ; electroencephalogram ; frequency spectrum ; α-, β- and γ-synuclein ; epigenetic ; protein aggregation ; SNARE-complex ; protein trafficking ; phytochemicals ; methylation ; histones ; γ-synuclein ; autoantibodies ; glaucoma ; α2-macroglobulin ; tear fluid ; intraocular pressure ; SARS-CoV-2 spike RBD domain ; amyloid aggregation ; post-COVID-19 neurodegeneration ; SARS-CoV-2 vaccine ; depression ; serotonin ; raphe nuclei ; Lewy bodies diseases ; E46K-SNCA ; cognition ; nonmotor ; clustering analysis ; multimodal MRI ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 7
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    Frontiers in Vascular Stiffness (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: The evaluation of vascular stiffness is becoming increasingly important in cardiovascular research to determine the properties of the arterial tree and clinically assesspatients. Current research addresses and debates some unresolved technical and methodological issues with measuring arterial stiffness, with the purpose of making it more reliable and clinically suitable. This Special Issue focuses on new methodological advances in vascular stiffness, as well as preclinical and clinical applications. A privileged space is reserved for new data and targeted reviews of the application of arterial stiffness and early vascular ageing measures regarding problems such as the stratification of risk of special populations and specific diseases.
    Keywords: arterial stiffness ; Arteriograph ; obstructive sleep apnea (OSA) ; continuous positive airway pressure (CPAP) ; metabolic syndrome (MS) ; adherence ; abdominal aortic aneurysm ; diabetes mellitus type 2 ; inflammatory marker ; vascular stiffness ; cardiovascular death ; degenerative aortic stenosis ; heat failure episodes ; pulsatile index ; resistive index ; aortic valve replacement ; transcatheter aortic valve implantation ; energy drinks ; pediatrics ; prevention ; aorta ; arterial distensibility ; augmentation index ; blood pressure amplification ; cardiovascular prevention ; elastic modulus ; pulse wave analysis ; pulse wave velocity ; prediabetes ; 11-dh-thromboxane ; cardiovascular risk ; IMT ; familial hypercholesterolemia ; selective LDL apheresis ; PCSK9 inhibitor monoclonal antibody ; thyroid ; parathyroid ; cardiovascular disease ; carotid distensibility ; carotid strain ; Young’s elastic modulus ; carotid compliance ; systemic sclerosis ; scleroderma ; vascular ageing ; central hemodynamics ; gut microbiota ; gut microbiome ; inflammation ; oxidative stress ; altitude ; altitude sickness ; aortic stiffness ; aortic distensibility ; atrial natriuretic factor ; blood pressure ; vascular age ; risk factors ; carotid distension ; primary prevention ; CAVI ; CAVI0 ; PWV ; comorbidity ; aging ; echo-tracking ; vascular ultrasound ; arterial properties ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJD Cardiovascular medicine
    Language: English
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  • 8
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    Recent Advances in Long-Acting Drug Delivery and Formulations (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: The Special Issue titled “Recent Advances in Long-Acting Drug Delivery and Formulations” encompasses versatile and innovative research domains of oral, ocular, brain, and topical delivery systems and chemical approaches (e.g., prodrugs), highlighting the progress made in identifying excipients (e.g., basic amino acids to ameliorate gastric side effects of non-steroidal anti-inflammatory drugs (NSAIDs)), polymers, and molecular targets to achieve more effective sustained release systems and safer medicine. In this Special Issue, 78 authors have contributed, with eleven original research articles spanning five continents (Asia, Europe, Africa, North America, and Australasia) providing important insights into the pharmaceutical sciences.
    Keywords: drug delivery ; nanotechnology ; alzheimer’s disease ; Amyloid-β ; solid lipid nanoparticles ; SHSY5Y cells ; altretamine ; cancer therapy ; sustained delivery ; hydroxyapatite nanoparticles ; chemical precipitation method ; polymeric film ; diabetes mellitus ; skin regeneration ; wound healing ; sodium alginate ; sodium carboxy methyl cellulose ; microwave ; cross-linking ; ketoprofen ; L-arginine ; L-lysine ; tris ; basic amino acids ; writhing ; gastric ulcer ; chitosan ; 1,3,5-benzene tricarboxylic acid ; hydrogels ; rheology ; alginate ; BSA ; Maillard reaction ; age-related-macular degeneration ; drug release ; fenofibrate ; retinal cells ; HIV ; long-acting subcutaneous injection ; raltegravir ; cyclisation-activated prodrugs ; β-blockers ; NSAIDs ; corticosteroids ; ocular delivery ; drug permeability ; QSPR ; MLR ; Alzheimer’s disease ; GSK-3β-Wnt/β-catenin ; PERK/CHOP/Bcl-2 ; oxidative stress ; cocoa ; vinpocetine ; diabetes ; salbutamol ; skeletal muscle atrophy ; sarcosine ; metabolomics ; factorial design ; controlled release ; topical delivery ; texture analysis ; bioadhesion ; intermolecular interactions ; hydroxypropyl methylcellulose ; polyvinylpyrrolidone ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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  • 9
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    Sports or/and Special Populations: Training Physiology in Health and Sports Performance (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-30
    Description: Several factors have been identified as interfering with the success, rehabilitation, and fitness of athletes from childhood to adulthood, as well as in para-sport, and special populations, according to research. The performance and health of this population are affected by the relationships between stress, maturation, training load, and recovery. Environmental approaches aim to increase efficiency and physiological adaptations in this sense. In various situations and conditions, however, this stimulus–performance–adaptation relationship varies.As a result, we received contributions related (but not limited) to the following topics: training load monitoring; stress and physiological responses during exercise or sports; recovery process after exercise; changes after stress and/or training load; physiology of training in health and sports performance.
    Keywords: visceral adipose tissue ; military ; metabolic syndrome ; cut-off points ; DXA ; warm-up ; muscle force ; performance ; resistance training ; thermal imaging ; physiology ; backstroke ; breaststroke ; start ; sink ; cortisol ; people with disabilities ; physical activities ; South Korea ; social determinants of health ; focus group interviews ; Paralympic Games ; Tokyo 2020 ; sociodemographic ; well-being ; resilience ; social support ; athletes ; disability ; performance indicators ; sports ; footwork ; reaction time ; agility ; physical activity environment ; relative importance ; priority ; pro bono ; intention ; pre-service physical activity instructor ; theory of planned behavior ; leisure time physical activity ; volunteering ; swimming ; social inclusion ; adapted physical activity ; respite care ; altitude ; hemoglobin ; erythropoietin ; hypoxia ; maximum volume of oxygen ; para powerlifting ; athletes with disabilities ; scoping review ; PAGER framework ; bibliometrics ; physical fitness ; body composition ; health ; measurement ; Down syndrome ; load-velocity relationship ; autoregulation ; load monitoring ; fixed-loading ; Wingate anaerobic performance ; paralympic sport ; para-rowing ; bibliometric analysis ; back pain ; sport ; sleep deficiency ; aerobic exercise ; oxidative stress ; hs-CRP ; stress ; hormones ; salivary glands ; endocrine ; autonomic nervous system ; immune system ; disabled athletes ; infection ; lymphocytes ; cytokines ; narrative review ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 10
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    Inflammation and Natural Products (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
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    Publication Date: 2023-11-30
    Description: Terrestrial and marine environments are inexhaustible sources of compounds and active extracts which have been employed in medicine since ancient times. The aim of this reprint is to collect new approaches around compounds and extracts isolated from natural products and their biological activity, with a focus on anti-inflammatory pathways. Thus, this reprint compiles full original papers and reviews articles published during 2023 in a Special Issue of Life, titled “Inflammation and Natural products”. The publications within this reprint are focused on secondary metabolites of plants demonstrating significant antioxidants and anti-inflammatory properties, among others, and clinical relevance in various pathological conditions. It also includes reviews that focus on natural therapies for topics such as arthritis, lung diseases, neuroprotection, skin photoprotection, and the impact of gender in the use of medicinal plants in relation to vascular diseases. The reprint of this Special Issue will serve as a reference text for researchers and academics, as well as those studying natural products and their pharmacological activities.
    Keywords: Laurus nobilis ; Arbutus undeo ; volatile compounds ; anti-diabetic ; anti-inflammatory ; antimicrobial ; Ziziphus jujuba leaves ; rutin ; quercetin ; chlorogenic acid ; lipophilic ointment ; healing activity ; anti-inflammatory properties ; Alzheimer’s disease ; biflavonoids ; ginkgetin ; neuroprotection ; ginkgo ; vascular dysfunction ; endothelium ; plant extracts ; gender ; safety ; botanicals ; garlic ; traditional medicine ; ethnopharmacology ; hesperidin ; inflammation ; respiratory lung diseases ; flavonoids ; usnic acid ; enantioselective ; plumbagin ; plumbaginaceae ; natural compound ; antioxidant ; antibacterial ; antiparasitic ; anti-senescence ; stem cells ; Polypodium leucotomos ; Fernblock® ; photoprotection ; photodermatoses ; photoaging ; hyperpigmentation ; rheumatoid arthritis ; triterpenes ; celastrol ; betulinic acid ; ginsenosides ; saponins ; essential oils ; Melissa officinalis ; oregano ; lavender ; Chios Mastic (Mastiha) ; glucocorticoid receptor ; anti-inflammatory actions ; apoptosis ; anti-hyperglycemic actions ; royal jelly ; anti-inflammatory activity ; antioxidant activity ; natural products ; anticancer potential ; biological activity ; systemic lupus erythematosus ; clinical ; autoimmune diseases ; natural product ; supplement ; medicinal plant ; immunomodulatory ; review ; herbal medicine ; psoriasis ; Ficus carica fruit extract ; JAK–STAT modulation ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
    Language: English
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