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  • bic Book Industry Communication::M Medicine  (242)
  • Cell & Developmental Biology
  • Inorganic Chemistry
  • English  (242)
  • 2020-2024  (242)
  • 2022  (242)
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  • 2020-2024  (242)
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  • 1
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    Advances in Autism Research (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-11-23
    Description: This book represents one of the most up-to-date collections of articles on clinical practice and research in the field of Autism Spectrum Disorders (ASD). The scholars who contributed to this book are experts in their field, carrying out cutting edge research in prestigious institutes worldwide (e.g., Harvard Medical School, University of California, MIND Institute, King’s College, Karolinska Institute, and many others). The book addressed many topics, including (1) The COVID-19 pandemic; (2) Epidemiology and prevalence; (3) Screening and early behavioral markers; (4) Diagnostic and phenotypic profile; (5) Treatment and intervention; (6) Etiopathogenesis (biomarkers, biology, and genetic, epigenetic, and risk factors); (7) Comorbidity; (8) Adulthood; and (9) Broader Autism Phenotype (BAP). This book testifies to the complexity of performing research in the field of ASD. The published contributions underline areas of progress and ongoing challenges in which more certain data is expected in the coming years. It would be desirable that experts, clinicians, researchers, and trainees could have the opportunity to read this updated text describing the challenging heterogeneity of Autism Spectrum Disorder.
    Keywords: autism spectrum disorder ; infants ; frontal EEG alpha asymmetry ; early detection ; autism spectrum disorders ; toddlers ; eye tracking ; joint attention ; longitudinal ; regression ; cytokines ; PAI-1 ; neuroinflammation ; gastrointestinal ; autism ; literature review ; comorbidity ; early intervention ; early intensive behavioral intervention ; behavioral intervention ; First Year Inventory ; early screening ; risk ; cross-cultural generalisability ; validity ; preschool teachers ; self-efficacy ; knowledge ; belief ; skills ; identify ; autism spectrum disorder (ASD) ; level 1 and level 2 screening tools ; systematic review ; COSMIN ; PRISMA ; screening ; infection ; prion ; meta-analysis ; motion analysis ; video signal processing ; neurodevelopmental disorders ; infant screening ; n/a ; developmental language disorder ; semantic features ; word learning ; central coherence ; biomarker ; p-cresol ; mouse social behavior ; dopamine ; ASD ; vision ; proprioception ; self-motion ; immersive virtual reality ; IVR ; HMD ; technology ; persuasive text writing ; perspective-taking ; adolescence ; intervention ; sign language ; imitation ; cognition ; language acquisition ; prevalence estimate ; predictors ; surveillance review ; Autism Spectrum Disorder (ASD) ; early intensive intervention ; developmental trajectories ; moderators and mediators of intervention. ; psychosis ; schizophrenia ; psychopathology ; AQ ; accuracy ; attention to detail ; self-awareness ; insight ; preconception risk factor ; Gilles de la Tourette ; obsession ; compulsion ; social behavior ; social impairment ; sensory profile ; sensory responsiveness ; feeding problems ; short sensory profile (SSP) ; sensory experience questionnaire (SEQ) ; coronavirus ; 2019-nCoV ; neurodevelopment ; child and adolescent psychiatry ; mental health prevention ; Asperger syndrome ; adults ; cerebrospinal fluid ; antibodies ; blood–brain barrier ; GAD65 ; Early Start Denver Model ; high-risk infants ; motor development ; high-functioning autism ; language ; experience ; communication ; autonomic nervous system ; wearable technologies ; EEG ; theory of mind ; adults and adolescents ; human figure drawings ; Draw-a-Man ; drawings maturity ; social perception ; ERP ; reward response ; RewP ; sensitization ; social skills intervention ; PEERS® ; adulthood ; diagnosis ; autistic traits ; action observation ; action prediction ; context ; priors ; hypothalamus ; amygdala ; oxytocin ; social cognition ; social interaction ; affiliative behavior ; neuroimaging ; COVID-19 ; challenging behavior ; dental care ; oral health ; medical procedures ; ICT ; wearable sensors ; migration ; Europe ; health system ; autism in adulthood ; intellectual disability ; regressive autism ; epilepsy ; challenging behaviors ; empathy ; executive functions ; attention deficit and hyperactivity disorder ; disruptive behavior disorders ; alexithymia ; anxiety ; depression ; TAS-20 ; TSIA ; parents ; broader autism phenotype ; autistic-like features ; social-cognitive development ; stereotypical behaviors ; visual impairment ; language profiles ; grammatical comprehension ; cannabinoids ; cannabidiol ; cannabidivarin ; THC ; problem behaviors ; sleep ; hyperactivity ; side effects ; motor performance skills ; Gulf ; BOT-2 ; machine learning ; employment ; telehealth ; ABA ; RCT ; cortisol ; group activity ; stress ; art ; assessment ; sensorimotor integration ; postural balance ; false positive report probability (FPRP) ; Bayesian false-discovery probability (BFDP) ; Genome-Wide Association Studies (GWAS) ; microbiome ; metabolomics ; study design ; biomarker discovery ; precise medicine ; bipolar disorder ; suicidal ideation ; suicidal attempts ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 2
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    Spinal Cord Injury and Transcutaneous Spinal Cord Stimulation (2022)
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    Publication Date: 2023-05-10
    Description: Recent research of epidural and transcutaneous electrical spinal cord stimulation has demonstrated unprecedented improvements in motor function thought to be irreversibly lost due to chronic, severe spinal cord injury. Studies in parallel assess these methods for spasticity management as an alternative to medications that are often accompanied by deleterious side effects. As a noninvasive intervention, transcutaneous spinal cord stimulation holds the great potential to find its way into wide clinical application. Its firm establishment and lasting acceptance as clinical practice in spinal cord injury will not only hinge on the demonstration of safety and efficacy, but also on the delineation of a conceptual framework of the underlying physiological mechanisms. This will also require advancing our understanding of immediate and temporary effects of transcutaneous spinal cord on neuronal circuits in the intact and injured spinal cord. The purpose of this collection of papers is to bring together peers in the field to share—and eventually fuse—their pertinent research into current neurorehabilitation practice by providing a clinical perspective and novel insights into the underlying mechanisms.
    Keywords: human ; neuromodulation ; neurorehabilitation ; non-invasive ; spinal cord injury ; transcutaneous spinal cord stimulation ; evoked potentials motor ; motor activity ; spinal cord stimulation ; spinal reflexes ; voluntary ankle control ; walking ; hand training ; combined intervention ; cervical spinal cord ; activity-based therapy ; gait ; locomotion ; paraplegia ; task-specific training ; tetraplegia ; use-dependent plasticity ; antispasmodic ; electrical stimulation ; pendulum test ; intensity effect ; muscle strength effect ; cervical ; corticospinal pathway ; spinal reflex ; electrically evoked spinal motor potentials ; cervical spinal cord injury ; motor evoked potentials ; automation ; electromyography ; noninvasive ; Parkinson’s disease ; posterior root-muscle reflexes ; spasticity ; transcutaneous ; biophysics ; H reflex ; M wave ; posterior root-muscle reflex ; posterior root stimulation ; spine alignment ; spinal cord ; spine ; spinal stimulation ; corticospinal tract ; functional connectivity ; movement ; sensorimotor networks ; task dependence ; interlimb coordination ; rehabilitation ; neurophysiology ; Hoffmann (H)-reflex ; motor-evoked potential ; electroencephalography ; event-related desynchronisation ; posterior root muscle reflex ; evoked potentials ; lumbar spinal cord ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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  • 3
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    Clinical Management and Challenges in Polytrauma (2022)
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    Publication Date: 2023-05-10
    Description: Trauma is still a leading cause of death in patients below 40 years of age. Clinical management of severely injured patients is challenging in all phases of treatment during the clinical course. Numerous factors, such as injury severity, injury pattern, patient characteristics and trauma system, affect the decision-making process in our patients. After the successful initial management of an unstable multiply injured patient, secondary definitive surgeries and reconstructions may have a risk for further systemic complications and the deterioration of the patient’s physiology. A “Safe Definitive Surgery” (SDS) concept considers the dynamics of the clinical course (prehospital, operations, complications, etc.) and the patient’s physiology. Due to the repeated re-evaluation and assessment of the patient’s clinical course, dynamics and adaptation of the treatment strategy, the safe management of polytraumatized patients is possible. Many unanswered questions still exist and need to be addressed in future studies: Which patients profit by the damage control strategy and which do not? When is it best to start with the definitive fixation of fractures in multiply injured patients? How can one improve the quality of life in polytraumatized patients? What are the strategies in elderly severely injured patients? With this Special Issue, we would like to stimulate research in the field of polytrauma in order to shed light on the above-mentioned questions
    Keywords: pelvic ring fracture ; PCCD ; position ; associated injuries ; geriatric trauma ; scoring ; polytrauma ; ISS ; AIS ; geriatric patients ; orthogeriatric ; E-bike injuries ; outcome ; injury pattern comparison ; traumatic injury ; reactive oxygen species ; phagocytosis ; CD14 ; CD16 ; CD62L ; fMLP ; PMA ; emergency surgery ; trauma team competence ; trauma system ; life-saving intervention ; trauma ; non-invasive external pelvic stabilizers ; bleeding ; pelvic fractures ; post mortem analysis ; biomechanical force ; pneumatic pelvic sling VBM® ; T-POD® ; cloth sling ; SAM Sling® ; trauma victims ; prehospital death ; Injury Severity Score (ISS) ; hemorrhage ; shock ; resuscitation ; coagulopathy ; oxygen transport ; endotheliopathy ; microcirculation ; macrocirculation ; orthopaedic trauma ; nutritional deficiencies ; vitamins ; lower extremity ; wound complications ; nutrition wound healing ; platelets ; immune system ; posttraumatic organ failure ; posttraumatic lung dysfunction ; posttraumatic hyperinflammation ; I-FABP ; biomarker ; intestinal damage ; hemorrhagic shock ; major trauma ; bic Book Industry Communication::M Medicine
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  • 4
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    Intraocular Pressure and Ocular Hypertension (2022)
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    Publication Date: 2023-05-10
    Description: Primary open-angle glaucoma (POAG) is a multi-factorial progressive optic neuropathy characterized by retinal ganglion cell degeneration and progressive visual field loss which, if left untreated, may lead to blindness. Increased intraocular pressure (IOP) is considered to be the main risk factor for developing POAG, and its reduction has been shown to correlate with a decrease in glaucoma incidence and progression. Considering that fewer than 10% of the subjects with ocular hypertension (OHT) will develop morphological and/or functional glaucomatous damage within 5 years if not treated, glaucoma causes and molecular changes leading to ocular tissue damage in glaucoma are still largely unknown. The contemporary treatment of POAG is mainly oriented towards reducing IOP; the importance of the IOP reduction in other types of glaucoma, such as the “normal pressure glaucoma”, is still discussed. The IOP value is maintained by balancing the amount of fluid contained within the anterior and posterior chambers of the eye; our comprehension of the mechanisms underlying the secretion and active and passive outflow of the aqueous humor is extremely important for improving the treatment of glaucoma. Innovative pharmacological approaches, and laser and surgical procedures aiming to reduce IOP, have been developed in recent years. This book provides a compendium of topics regarding IOP, aqueous humor dynamics, tonometry, and medical and surgical techniques developed to reduce the IOP in subjects with ocular hypertension or glaucoma.
    Keywords: intraocular pressure ; serum calcium ; female ; ab interno trabeculotomy ; glaucoma ; incision in the Schlemm’s canal in degrees ; post-surgical complication ; neuroretinal rim reversal ; Bruch’s membrane opening-minimum rim width ; trabeculectomy ; refractive error ; neuroretina ; myopia ; intraocular pressure (IOP) ; tonometry ; Goldmann applanation tonometer (GAT) ; central corneal thickness (CCT) ; ocular hypertension ; higher-order aberrations ; Kahook Dual Blade ; age ; central corneal thickness ; Goldmann Applanation tonometer ; non-contact tonometer ; rebound tonometer ; iCare ; open angle glaucoma (OAG) ; Schlemm’s canal viscodilation ; OMNI viscosurgical system ; minimally invasive glaucoma surgeries (MIGS) ; trabeculotomy ; cataract extraction ; aqueous humor ; GDF15 ; serum ; intravitreal injection ; anti-VEGF agents ; trabecular meshwork ; Matrigel ; 3D culture ; outflow ; cytoskeleton ; rho-kinase inhibitor ; prostaglandin analog ; childhood glaucoma ; aphakia ; pseudophakia ; cataract surgery ; lensectomy ; management (or therapy) ; glaucoma drainage device ; cyclodestruction ; corneal biomechanics ; ocular response analyzer ; ORA ; corneal hysteresis ; non-penetrating deep sclerectomy ; Esnoper V-2000 implant ; glucocorticoids ; safety profile ; intranasal administration ; inhaled administration ; systemic administration ; steroid response ; canaloplasty ; non-perforating surgical procedures ; pseudoexfoliation glaucoma (PEXG) ; Schlemm’s canal ; phase-sensitive optical coherent tomography ; pulsatile motion ; IOP fluctuation ; primary open-angle glaucoma ; intraocular pressure measurement ; iCare tonometry ; Perkins tonometry ; standardized anaesthesia ; corneal thickness ; progression ; risk stratification ; XEN GelStent ; corneal resistance factor ; open-angle glaucoma ; n/a ; laser treatment ; dropless treatment ; thyroid-associated ophthalmopathy ; extraocular muscle ; magnetic resonance imaging ; T2 relaxation time ; bic Book Industry Communication::M Medicine
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  • 5
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    Virus Infection in Equine (2022)
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    Publication Date: 2023-05-10
    Description: The increased international transportation and trade over the last few decades have increased the risk of the introduction of pathogens into new areas. Global climate change has influenced environmental conditions and the ability of pathogens to survive, and has changed the habitats of certain vectors and hosts. These processes have led to the emergence or re-emergence of various pathogens in different parts of the world, including those affecting horses. This Special Issue features some aspects regarding several well recognized as well as some new and emerging equine viral pathogens, highlighting the need for updated epidemiological data. Such surveillance is crucial for proper decision making by clinicians and by regulatory authorities. Also demonstrated by the recent global emergence of SARS-CoV-2, the development of an effective infrastructure for the rapid and effective detection and control of novel viral pathogens, as well as re-emerging ones, is essential. Horses should play an important role in such surveillance systems, not only for equine pathogens but also as sentinels to other viruses and arboviruses. As was demonstrated in several examples in this Special Issue, it is important to remember, both as clinicians and as researchers, that when facing clinical cases, even when those are common, we should remain alert to the possibility of the intrusion of unknown pathogens and, therefore, should seek a definitive diagnosis. This may allow for the early detection of emerging or re-emerging pathogens.
    Keywords: equine coronavirus ; horse ; enteric disease ; ECoV ; seroprevalence ; equine ; viruses ; loop-mediated isothermal amplification ; insulated isothermal polymerase chain reaction ; field-deployable ; point-of-care testing ; Huculs ; viral status ; immunological status ; equine viral diseases ; EHV-1 ; EHV-4 ; ELISA ; VNT ; Morocco ; equine parvoviruses ; equine parvovirus hepatitis ; equine parvovirus CSF ; equine copivirus ; nasal fluid ; blood ; qPCR ; sick equids ; healthy horses ; gammaherpesvirus ; horses ; respiratory disease ; equine herpesvirus 1, -2, -4, -5 ; equine influenza ; quantitative PCR ; equine encephalosis virus ; EEV ; epidemiology ; clinical disease ; control ; Culicoides ; SARS-CoV-2 ; nasal secretions ; n/a ; bic Book Industry Communication::M Medicine
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  • 6
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    Precision Medicine in Solid Tumors (2022)
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    Publication Date: 2023-05-10
    Description: In the era of precision medicine, the use of molecularly targeted therapies in selected patients has led to a paradigm change in cancer treatment. Multiple studies have demonstrated the benefits of therapies that are chosen based on the molecular profile of the tumor and also from the liquid biopsy. With genomics' increasing ability, a routine transcriptomics analysis of advanced/metastatic cancers is now feasible in most cancer hospitals, including community cancer centers. This is an unprecedented shift in the management of cancers irrespective of their organ types, which not only improved the outcome but also opened several new avenues in research and practice, such as immune-check-point inhibitors, tumor-TME co-evolution in the development of resistance, longitudinal liquid biopsies, biomarkers screening and the management of electronic medical records.This book brings together these crucial areas of investigation. The research presented here attempts to address the current issues to provoke thoughts for the future. The future of precision medicine will have to embrace a shift from in vitro, in vivo/PDX models for the mechanistic study to a more functional test based on the scientific interrogation of genomic data, in the form of functional precision medicine. We will also have to combat the element of noise in the multitudes of data and impart the regulatory structure to make judicious use of the data. The expectations for functional precision medicine are high. We aspire to witness a tremendous improvement in patient outcomes, from better to best, down the road that will match the clinical guidelines.
    Keywords: pediatric tumors ; tumor mutational burden ; TMB ; whole-exome sequencing ; gene panel sequencing ; immune checkpoint inhibitors ; glioblastoma prognosis ; overall survival ; extent of resection ; random forest ; Decision tree ; personalized precision oncology ; circulating free DNA ; liquid biopsy ; epidermal growth factor receptor ; tyrosine kinase inhibitor ; osimertinib ; comprehensive genomic profiling ; molecular genotyping ; intratumor heterogeneity ; multiple biopsies ; tumor evolution ; clonality classification ; strategic therapeutic intervention ; thymoma ; driver mutation ; sequencing ; molecular barcoding ; EGFR mutation ; EGFR-TKI ; cfDNA ; NGS ; digital enrichment ; next-generation sequencing ; solid cancer ; universal health-care system ; precision medicine ; presumed germline findings ; clinical guideline ; non-small cell lung cancer ; outcome ; adjuvant chemotherapy ; anaplastic lymphoma receptor tyrosine kinase ; HNSCC ; ctDNA ; tDNA ; DDR genes ; PARP inhibitors ; new drug development ; next-generation sequencing (NGS) ; open data ; regulatory reform ; tumor profiling test ; triple-negative breast cancer (TNBC) ; breast cancer ; targeted therapy ; TNBC subtypes ; immunotherapy ; cancer ; screening ; smoking ; electronic records ; PD-L1 ; cancer-associated fibroblasts ; resistance ; chemotherapy ; CTC ; immunocytochemistry ; parallel double-detection ; laboratory-friendly ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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  • 7
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    Enhancing Mesenchymal Stem Cells (MSCs) for Therapeutic Purposes (2022)
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    Publication Date: 2023-05-10
    Description: The regenerative and immunomodulatory properties of mesenchymal stem cells (MSCs) have made these cells the focus of multiple pre-clinical studies and clinical trials. While the results from these clinical studies have established that MSCs are safe, the efficacy of these cells is not as well-established. In this regard, there have been increased efforts towards generating potentiated/activated MSCs with enhanced therapeutic efficacy. Research on the mechanisms for enhancing MSC potency and efficacy is an area of active study with great potential for translation into clinical settings. The purpose of this book is to bring together recent research from a broad range of topics relating to potentiation strategies for enhancing MSC therapeutic efficacy, including growth factor pre-conditioning, hypoxia, and 3D culture. The research compiled in this book increases the basic understanding of MSC culture techniques and describes some MSC preparations for potential novel therapeutic applications.
    Keywords: cell therapy ; immunomodulation ; polyunsaturated fatty acid ; CD206 ; phagocytosis ; mesenchymal stem cells ; Vadadustat ; AKB-6548 ; preconditioning ; priming ; secretome ; chemotaxis ; Wharton’s jelly mesenchymal stem cells ; umbilical cord ; oxygen conditions ; secretory profile ; neuroprotection ; mesenchymal stromal cells ; 3D culture ; neurospheres ; spheroids ; pluripotency ; neural ; quiescence ; mesothelioma ; malignant pleural mesothelioma (MPM) ; liver cirrhosis ; placenta-derived mesenchymal stem cells ; WKYMVm ; combination therapy ; iPSC-derived MSCs ; iMSC secretome ; pre-conditioning ; angiogenesis ; IFN-γ ; hypoxia ; potentiation of iMSC efficacy ; nanofiber-hydrogel composite ; spinal cord injury ; inflammation ; macrophages ; secondary injury ; astrocytes ; axon growth ; adipose tissue-derived stem cells (ASCs) ; autophagy ; rapamycin ; 3-methyladenine ; immunosuppression ; exosome ; engineered cardiac patches ; adipose-derived stem cell ; paracrine potential ; osteogenic differentiation ; hepatocyte growth factor ; fibroblast growth factor 2 ; bic Book Industry Communication::M Medicine
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  • 8
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    Novel Methods of Diagnostics of Thyroid and Parathyroid Lesions (2022)
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    Publication Date: 2023-05-10
    Description: Thyroid nodular disease is one of the most frequent endocrine diseases. The prevalence of thyroid focal lesions detected by imaging techniques, according to studies on different populations, ranges from 10 to 70%. In a population of women over 50 years of age, approximately half of them will have a thyroid focal lesion. However, only 18% of thyroid nodules are diagnosed as malignant. Thyroid nodular disease is the most frequently diagnosed endocrine pathology, while thyroid cancer constitues the most common endocrine malignancy and is reponsible for about 67% of deaths due to neoplasms derived from endocrine organs. The incidence of thyroid cancer has risen by about 240% in the last three decades. Due to the increased availability of imaging techniques, recently, a rise in the detectability of thyroid cancer at the stage of microcarcinoma has been observed. Diagnostic and therapeutic decisions in patients with thyroid nodules require an interdisciplinary consensus between endocrinologists and physicians of other specialities (radiologists, pathologists, surgeons, oncologists). This book focuses on current trends in novel techniques of thyroid nodule diagnostics before they are implemented in the current guidelines on the management of thyroid nodular disease.
    Keywords: thyroid nodule ; care pathway ; guidelines ; fine-needle aspiration cytology ; thyroid cancer ; COLD-PCR ; digital PCR ; BRAFV600E ; papillary thyroid cancer ; liquid biopsy ; thyroid nodules ; ultrasound ; computer-aided diagnosis ; S-Detect ; EU-TIRADS ; PTC ; thyroid ; metastasis ; Snail-1 ; primary hyperparathyroidism ; parathyroidectomy ; remedial surgery ; ectopic mediastinal localization ; persistent hypercalcemia ; ectopic thymus ; shear wave sonoelastography ; strain elastography ; metastatic lymph nodes ; shear wave elastography ; interobserver variability ; tissue aspirate parathyroid hormone assay ; recurrent renal hyperparathyroidism ; persistent renal hyperparathyroidism ; parathyroid sonography ; parathyroid scintigraphy ; thyroid surgery ; vocal cord dysfunction ; vocal cord palsy ; loss of signal ; complications ; parathyroid adenoma ; hyperparathyroidism ; PET-CT ; FEC ; FCH ; n/a ; postsurgical hypoparathyroidism ; risk-factor analysis ; time course ; bic Book Industry Communication::M Medicine
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    Bio-Functional Natural Products in Edible Resources for Human Health and Beauty (2022)
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    Publication Date: 2023-05-10
    Description: Natural products remain important repositories of promising therapeutic candidates due to their rich chemical and biological diversity. The Special Issue on "Bio-functional Natural Products in Edible Resources for Human Health and Beauty" is intended to offer biological active natural products from edible resources as candidates and/or leads for pharmaceuticals, dietary supplements, functional foods, cosmetics, and food additives, etc. The research fields of this Special Issue include natural products chemistry, phytochemistry, pharmacognosy, food chemistry, bioorganic chemistry, chemical biology, molecular biology, molecular pharmacology, and other related research fields of bioactive natural products obtained from the edible resources. This eBook contains 12 Reviews and Articles focusing on these research areas. I hope that this eBook will be of benefit to outstanding professionals in these research areas.
    Keywords: sweet potato ; anthocyanin compositions ; biosynthesis structural genes ; transcription factor ; Vaccinium vitis-idaea ; lingonberry ; sugars ; cultivated berries ; wild berries ; HPLC–ELSD ; banana inflorescences ; anti-inflammatory activity ; antiparasitic activity ; UPLC-ESI-MS ; arylpropanoid sucroses ; Lavandula stoechas essential oil ; topical anti-inflammatory effect ; anticancer activity ; melanoma cell lines ; 1,8-Cineole ; fallopian tube ; phytoestrogen ; ciliated cell ; secretory cell ; Notch ; sea buckthorn ; phenolic compounds ; triterpenic compounds ; carotenoids ; chlorophyll ; freeze-drying ; leaf powder ingredients ; leukemia ; leukemic stem cell ; FLT-3 ; chemotherapeutic drug ; curcumin ; co-treatment ; tomato seed ; lycoperoside ; steroidal saponin ; ceramide ; transepidermal water loss ; anti-inflammation ; anemia ; cognition ; elder ; hemoglobin ; iron ; Oryza sativa ; rice ; medicine food homology ; functional food herbs ; type 2 diabetes mellitus ; gut microbiota ; aging of the human body ; medicinal plants ; antioxidant ; anti-inflammatory ; anti-glycation ; anti-neurodegenerative properties ; sesame oil aroma ; 2,5-dimethylpyrazine ; 2-methoxy phenol ; water-immersion stress ; antianxiety ; elevated plus-maze test ; dual specificity phosphatase 1 ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Marine Drug Research in China: Selected Papers from the 15-NASMD Conference (2022)
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    Publication Date: 2023-05-10
    Description: The Book covers this whole field, from the discovery of structurally new and bioactive natural products (including biomacromolecules), from marine macro-/micro-organisms, to the pharmacodynamics, pharmacokinetics, metabolisms, and mechanisms of marine-derived lead compounds, both in vitro and in vivo, along with the synthesis and/or structural optimization of marine-derived lead compounds and their structure–activity relationships. Taken together, this Special Issue reprint not only provides inspiration for the discovery of marine-derived novel bioactive compounds, but also sheds light on the further research and development of marine candidate drugs.
    Keywords: Antarctic krill (Euphausia superba) ; peptide ; antioxidant activity ; stability ; oyster ; plasma ; peptidome ; antimicrobial peptides ; cytotoxicity ; actinomycete ; piericidins ; absolute configuration ; Pestalotiopsis heterocornis ; heterocornols ; anti-inflammatory activity ; sponge-derived fungus ; sclerotides ; lipodepsipeptide ; Aspergillus sclerotiorum ; nasopharyngeal carcinoma ; AChE inhibitory ; vascular endothelial cell ; flavonoid ; oxidized low-density lipoprotein ; Nrf2 ; apoptosis ; butyrolactone I ; food allergy ; metabolism ; pharmacokinetics ; actinomycin X2 ; microbial pigments ; dyeing ; silk ; antibacterial properties ; PD-L1 ; virtual screening ; pharmacophore modeling ; ADME ; molecular dynamics ; xanthones ; ascidian-derived fungus ; Diaporthe sp. ; anti-glioma activity ; antiaging ; Sonneratia apetala ; signaling pathway ; Caenorhabditis elegans ; mutants ; coral-derived fungi ; Aspergillus hiratsukae ; meroterpenoids ; antibacterial activity ; cytotoxic activity ; deep-sea-derived fungus ; Aspergillus puniceus ; isoquinoline alkaloid ; protein tyrosine phosphatase inhibitor ; antibacterial ; Aspergillus sp. ; geodin ; semisynthesize ; insecticidal activity ; Arca inflata ; antitumor peptide ; MAPK signaling ; calmodulin ; colorectal cancer ; methicillin-resistant Staphylococcus aureus ; actinomycin D ; Streptomyces parvulus ; mechanism ; mangrove endophytic Pestalotiopsis ; Sdy-1 ; antitumor activity ; Wnt signaling ; β-catenin ; eremophilane sesquiterpenoids ; mangrove-derived fungus ; Penicillium sp. ; Oceanapia ; sponge ; secondary metabolites ; biological activities ; drug design ; anticancer ; cyclic pentapeptide ; galaxamide analogues ; skipjack tuna (Katsuwonus pelamis) muscle ; angiotensin-I-converting enzyme (ACE) peptide ; molecular docking ; nitric oxide (NO) ; endothelin-1 (ET-1) ; Trichoderma longibrachiatum ; sesquiterpene glycoside ; antimicrobial activity ; marine fungi ; Aspergillus unguis ; depsides ; depsidones ; osteoclast differentiation ; soft-coral-derived fungus ; pyranodipyran derivatives ; tyrosyl DNA phosphodiesterase 1 inhibitory activities ; fluorescent properties ; butenolides ; enantiomers ; Aspergillus terreus ; pancreatic lipase ; NAFLD ; fucoxanthin ; adenosine monophosphate-activated protein kinase (AMPK) ; nuclear factor erythroid-2-related factor 2-mediated (Nrf2) ; Toll-like receptor 4-mediated (TLR4) ; Aspergillus flavipes HN4-13 ; emodin ; macroporous resin XAD-16 ; adsorption kinetics and isotherms ; enrichment ; tetramic acid derivatives ; deep-sea fungus ; clavipitacae ; Lecanicillium fusisporum ; chronic kidney disease ; fucoidan ; cognitive dysfunction ; neuroinflammation ; oxidative stress ; GSK3β-Nrf2-HO-1 signaling ; microglial polarization ; deep-sea actinomycetes ; aromatic acids ; oximes ; antihyperlipidemic ; phycocyanin ; microbiota ; transcriptome ; IL-17 pathway ; Hahella ; prodiginine ; chejuenlide ; genome mining ; LC-MS/MS ; CDK4/6 ; marine compounds ; pharmacophore construction ; ADMET ; mm-pbsa ; bic Book Industry Communication::M Medicine
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