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  • R5-920  (142)
  • AERODYNAMICS
  • ASTROPHYSICS
  • Cell & Developmental Biology
  • Chemistry
  • Fisheries
  • GEOPHYSICS
  • fisheries stakeholders
  • MDPI - Multidisciplinary Digital Publishing Institute  (142)
  • Scandinavian University Press (Universitetsforlaget)  (1)
  • Berlin, Heidelberg : Springer
  • Logos Verlag Berlin
  • New York, NY : Anamaya Publishers
  • English  (143)
  • 2020-2024  (143)
  • 2021  (143)
Collection
Publisher
Language
  • English  (143)
Years
  • 2020-2024  (143)
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  • 1
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
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  • 2
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 3
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders;celiac disease;gluten intolerance ; bic Book Industry Communication::M Medicine
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  • 4
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
    Language: English
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  • 5
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
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  • 6
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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  • 7
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
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  • 8
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In the last few years, an increasing number of individuals have adopted a gluten free diet (GFD). A significant proportion of that includes patients affected by celiac disease (CD), who have to follow a strict GFD for medical purposes. However, a high number of individuals are currently following a GFD without medical counseling and without a specific diagnosis needing a gluten withdrawal from the diet. This is due to the frequently incorrect information diffused on the Internet and mass media on the topic of GFD. For these reasons, research on the GFD and its clinical use and biological effects is urgently needed.
    Keywords: R5-920 ; RC620-627 ; gluten ; n/a ; mental health ; 33-mer ; gut motility ; gluten re-introduction ; teenagers ; gastric emptying ; islet of Langerhans ; children ; high-fat diet-induced obesity ; affective disorders ; FODMAP intake ; Brazilian CD-QoL ; DQ2.5-glia-?3 epitopes ; place of residence ; zinc ; glutenin ; quality of life (QoL) ; mood disorders ; magnesium ; dietary adherence ; coeliac disease ; food habit ; villous atrophy ; pepsin ; peptides derived from gluten in faeces and urine ; beta cell ; body mass index (BMI) ; oral food challenge ; gliadin ; ?-gliadin ; non-celiac gluten sensitivity ; celiac disease ; wheat ; outcome ; DQ2.5-glia-?1 ; DQ2.5-glia-?2 ; gut microbiota ; type 2 diabetes ; major depressive disorder ; micronutrient ; beta-cell stress ; non-coeliac gluten sensitivity ; screening ; gluten free diet ; gluten-related disorders ; threshold ; diary recommended intake ; wheat species ; non-coeliac wheat sensitivity ; body composition ; serology ; educational level ; mineral ; disease duration ; gastrointestinal symptoms ; gluten-free diet ; NOD mouse ; diagnosis ; osteoporosis ; nutrition ; cholecyst ; wheat allergy ; celiac disease (CD) ; quality of life ; microbiota ; questionnaire ; nutritionists ; structured questionnaires ; Pseudomonas ; intestinal permeability ; Celiac Disease ; economic status ; effectiveness ; type 1 diabetes ; cost ; calcium ; irritable bowel syndrome ; adherence ; non celiac gluten sensitivity ; deficiency ; gluten sensitivity ; iron ; low FODMAP diet ; depression ; clinic ; duodenal biopsies ; fortification ; mucosal recovery ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
    Publication Date: 2023-12-21
    Description: The recent advances in optical sources and detectors have opened up new opportunities for sensing and imaging techniques which can be successfully used in biomedical and healthcare applications. This book, entitled ‘Optical Methods in Sensing and Imaging for Medical and Biological Applications’, focuses on various aspects of the research and development related to these areas. The book will be a valuable source of information presenting the recent advances in optical methods and novel techniques, as well as their applications in the fields of biomedicine and healthcare, to anyone interested in this subject.
    Keywords: R5-920 ; TA1-2040 ; RM1-950 ; fiber optic sensor ; computational optical sensing and imaging ; imaging spectroscopy ; spectral imaging ; optical coherent tomography ; optical feedback interferometry ; optical tomography ; Raman sensing and imaging ; bic Book Industry Communication::M Medicine
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  • 10
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Supporting initiation, development and resolution of appropriate immune responses is key to survival. Many nutrients and dietary components have been purported to have a role in supporting optimal immune function. This is vital throughout the life course, from the development and programming of the immune system in early life, to supporting immunity and reducing chronic inflammation in older people. In this special issue of Nutrients, we examine the evidence for the role of diet and dietary components in promoting protective immunity.
    Keywords: R5-920 ; RC581-607 ; immunonutrition ; supplementation ; superoxide dismutase (SOD) ; fermented milk ; selenocysteine ; dendritic cells ; lipoxygenase (LOX) ; chronic inflammatory conditions ; formulation ; immune system ; cytokines ; skeletal muscle ; zinc ; non-digestible carbohydrates ; Toll-like receptor ; carbohydrates ; fiber ; lymphocytes ; antibody ; infants ; liver ; macrophage ; inflammatory process ; probiotic ; plant ; older people ; gut barrier ; infection ; amino acids ; gut ; T helper 1 (Th1) ; immunity ; T cells ; bioactive peptide ; inhibitor of kappa kinase (IKK) ; inflammation ; adhesion molecules ; leukocytes ; human milk oligosaccharides ; vitamin D ; food structure ; vitamin E ; mitogen-activated protein Kinase (MAPK) ; gut microbiota ; weaning ; homeostasis ; intestinal immune system ; extra-cellular signal regulated kinases (ERK) ; cyclooxygenase (COX) ; oxidative stress ; life course ; polyphenols ; oligosaccharides ; micronutrients ; Th17 ; obesity ; tolerance ; arachidonic acid ; growth factors ; anti-inflammation ; age-related immunity ; prebiotic ; biomarker ; microbiome ; functional foods ; immunosenescence ; nutrition ; molecular mechanisms ; metabolism ; macronutrients ; toll-like receptor 4 ; sepsis ; nutrition guidelines ; microbiota ; immunomodulation ; inflammatory markers ; elderly ; Th1/Th17 response ; adults ; reactive oxygen species (ROS) ; anorexia nervosa ; macrophages ; autoimmune diseases ; fatty acids ; T cell ; Treg ; breast milk ; nitric oxide synthase (NOS) ; chemokines ; anti-tumorigenic ; metabolites ; deficiency ; protein hydrolysate ; nuclear factor kappa-light-chain-enhancer of activated B cells (NF-?B) ; cancer ; bic Book Industry Communication::M Medicine
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  • 11
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Several promising techniques have been developed to overcome the poor solubility and/or membrane permeability properties of new drug candidates, including different fiber formation methods. Electrospinning is one of the most commonly used spinning techniques for fiber formation, induced by the high voltage applied to the drug-loaded solution. With modifying the characteristics of the solution and the spinning parameters, the functionality-related properties of the formulated fibers can be finely tuned. The fiber properties (i.e., high specific surface area, porosity, and the possibility of controlling the crystalline–amorphous phase transitions of the loaded drugs) enable the improved rate and extent of solubility, causing a rapid onset of absorption. However, the enhanced molecular mobility of the amorphous drugs embedded into the fibers is also responsible for their physical–chemical instability. This Special Issue will address new developments in the area of electrospun nanofibers for drug delivery and wound healing applications, covering recent advantages and future directions in electrospun fiber formulations and scalability. Moreover, it serves to highlight and capture the contemporary progress in electrospinning techniques, with particular attention to the industrial feasibility of developing pharmaceutical dosage forms. All aspects of small molecule or biologics-loaded fibrous dosage forms, focusing on the processability, structures and functions, and stability issues, are included.
    Keywords: R5-920 ; RM1-950 ; antibacterial activity ; piroxicam ; n/a ; tissue engineering ; biotechnology ; polydextrose ; solvent casting ; antibacterial ; drug delivery ; diabetic ; pectin ; nanotechnology ; nanocomposite ; hydroxypropyl methyl cellulose ; poorly water-soluble drug ; artificial red blood cells ; oral dosage form ; Lactobacillus ; scanning electron microscopy ; wound healing ; UV imaging ; wetting ; biocompatibility ; scale-up ; polylactide-co-polycaprolactone ; nanofibers ; growth factor ; drug release kinetics ; hydrogel ; differential scanning calorimetry ; bacterial bioreporters ; physical solid-state properties ; PCL ; coaxial spinning ; drug delivery system ; haemanthamine ; probiotics ; amphiphilic nanofibers ; wound dressings ; grinding ; scanning white light interferometry ; biopharmaceuticals ; clove essential oil ; viability ; plant-origin alkaloid ; oligochitosan ; local delivery ; electrospinning ; Lactococcus ; self-assembled liposomes ; microcapsules ; microfibers ; nanofiber ; in situ drug release ; biomedical ; core-sheath nanofibers ; processability ; polymeric carrier ; aceclofenac ; drying ; gentamicin sulfate ; traditional electrospinning ; electrospinning and electrospray ; fourier transform infrared spectroscopy ; drug release ; gelatin ; ultrasound-enhanced electrospinning ; 3D printing ; bic Book Industry Communication::M Medicine
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  • 12
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In this special issue of Diagnostics, expert contributors have produced up-to-date research studies and reviews on various topics related to the diagnosis of dementia and cognitive impairment. The methods of the assessments discussed extend from simple neurological signs, which may be elicited in the clinical encounter, through cognitive screening instruments, to sophisticated analyses of neuroimaging and cerebrospinal fluid biomarkers of disease. It is hoped that these various methods may facilitate earlier diagnosis of dementia and its subtypes, and provide differential diagnosis of depression and functional cognitive disorders, as a prelude to meaningful interventions.
    Keywords: R5-920 ; screening ; MoCA ; neurodegeneration ; accuracy ; frontotemporal dementia ; cognitive assessment ; Free-Cog ; molecular imaging ; Alzheimer’s ; standardised mini-mental state examination ; decision tree ; differential diagnosis depression vs. MCI/dementia ; computerized cognitive assessment ; quantification ; Alzheimer’s disease ; functional cognitive disorder ; diagnosis ; Triple Test ; diagnostic imaging ; neurocognitive disorder ; feasibility ; TYM-MCI ; amyloid ; cerebrospinal fluid ; dementia ; precision medicine ; Mini-Addenbrooke’s Cognitive Examination ; memory ; depression in old age ; quick mild cognitive impairment screen ; cognition ; nuclear medicine ; TYM ; Rapid Cognitive Screen ; 18F-FDG ; functional neurological disorder cognition ; stroke ; sensitivity and specificity ; Codex ; mortality ; mild cognitive impairment ; cognitive screening instruments ; cognitive impairment ; aging ; SKT (Syndrom-Kurztest) ; PET ; executive function ; bic Book Industry Communication::M Medicine
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  • 13
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. This Special Issue gathers eight research articles covering a broad range of strategies on how to combat spinal cord injuries, from searching for therapeutic target molecules, tackling inflammatory reactions, utilizing cell therapy or cell-based products, combined strategies for axonal plasticity assessment, and prevention of post-surgical epidural adhesions. Moreover, four reviews cover recent findings about the role of stress-activated protein kinases in SCI; progress in stem cell therapies; the mechanisms and benefits of activity-based physical rehabilitation therapies with adjuvant testosterone; and, finally, translational regenerative therapies for chronic spinal cord injury.
    Keywords: R5-920 ; RM1-950 ; spinal cord injury ; neuroinflammation ; cell therapy ; transcriptomics ; cytokines ; hydrogels ; p38. ; neuronal regeneration ; extracellular matrix ; epidural adhesions ; neuroplasticity ; bic Book Industry Communication::M Medicine
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  • 14
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue provides an overview of pediatric integrative medicine, an emerging field that blends conventional and evidence based complementary therapies with an emphasis on preventive health and wellbeing.
    Keywords: R5-920 ; RJ1-570 ; cognitive behavioral therapy ; pain rehabilitation ; n/a ; education ; pediatric integrative medicine ; musical therapy ; mind-body ; non-pharmacological therapy ; guided imagery ; complementary ; infant ; pediatric ; multidisciplinary pain management strategies ; integrative medicine ; qualitative ; advocacy ; clinic model ; massage ; obesity ; Kneipp ; multidisciplinary ; adolescents ; mindfulness ; sucrose ; program development ; vision ; complementary therapies ; residents ; art therapy ; pastoral care ; academic medicine ; kindergarten ; yoga ; assessment of withdrawal ; clinical practice ; pediatric integrative nursing ; eHealth ; mindful eating ; opioid reduction therapy ; burnout ; resilience ; pediatric blood and marrow transplant ; preventive lifestyle behaviors ; biofeedback ; pain ; migraine ; Integrative therapies ; creative arts therapy ; weaning of opioids ; implementation ; yoga therapy ; mindfulness-based stress reduction ; withdrawal ; music therapy ; hypnosis ; acupuncture ; premature ; chronic illness ; meditation ; pediatrics ; skin-to-skin contact ; opioid therapy ; self-regulation ; headache ; PIMR ; breastfeeding ; bic Book Industry Communication::M Medicine
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  • 15
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book provides an overview of the design and physico-chemical properties of nanoparticles developed for biomedical applications such as targeting and detection of pathologies, nanovectorization of drugs, radiosensitization, metal detection, and nanocomposite implants. The considerations necessary when developing a new nanomedicine are also developed, including toxicological investigation, biodistribution, and efficacy. This book provides an accurate and current representation of the field by addressing the promises and hurdles of nanomedicine via 20 different pertinent studies. Covering a wide range of areas, this book is an excellent partner for physico-chemists, doctors, pharmacologists, and biochemists working on nanosciences dedicated to medicine, both in industry and in academia.
    Keywords: R5-920 ; alginate ; chitosan ; gold nanoparticles ; biochemical mechanism ; cancer imaging ; lignin ; thioredoxin reductase ; antimiR ; nanoparticles ; surface enhanced Raman scattering ; biomedical applications ; protein ; multidrug resistant (MDR) microorganisms ; nano-bio interaction ; curcumin ; autophagy ; MIC ; nanoparticle ; biocompatible ; gene delivery ; self-assembly ; glioblastoma ; dual functional imaging nanoprobe ; SERS ; antibiotics ; biogenic nanoparticles ; Hg2+ ions detection ; antimicrobial ; histamine ; layer-by-layer ; dihydroartemisinin ; computational electromagnetism ; photolysis ; Ag-film ; chitosan nanoparticles ; UiO-66 ; plasma liquid Interactions ; anticancer ; MBC ; nanophotonics ; targeted nanoparticles ; near-infrared ; hybrid Fe-Si nanoparticles ; FTIR ; thermoplastic polymer ; synergism ; prognosis ; medical devices ; silver nanoparticles ; glioma ; plasma ; iron oxide superparamagnetic nanoparticles ; oxidative stress ; mycosynthesis ; membrane integrity ; drug delivery ; nanocomposites ; finite element method ; cell labeling ; in vivo application ; non-thermal plasma ; nanocellulose ; biocompatibility ; liposomes ; nanocarriers ; upconversion nanoparticles ; Candida glabrata ; nanomaterials ; middle ear prosthesis ; short-wave infrared ; cytoreduction surgery ; fibril ; nanostars ; fluorescent nanoparticle ; density functional theory calculations ; cross-link ; mitoxantrone ; heat ; SERS sensor ; Caco2 cells ; apoptosis ; surface-enhanced Raman spectroscopy (SERS) ; MFC ; magnetic nanoparticles ; antibiotic resistance ; laser pyrolysis ; cytotoxicity ; core-shell nanoparticles ; enzyme ; extracellular ; nanomaterial synthesis ; cancer cell targeting ; nanodiamond ; breast cancer ; metal-enhanced fluorescence (MEF) ; PEG ; radiation ; trans-resveratrol derivative ; radiosensitization ; cancer ; surface-enhanced Raman scattering (SERS) ; TEM ; bic Book Industry Communication::M Medicine
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  • 16
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The analysis of circulating tumor cells (CTCs) as a real-time liquid biopsy approach can be used to obtain new insights into metastasis biology, and as companion diagnostics to improve the stratification of therapies and to obtain insights into the therapy-induced selection of cancer cells. In this book, we will cover all the different facets of CTCs to assemble a huge corpus of knowledge on cancer dissemination: technologies for their enrichment, detection, and characterization; their analysis at the single-cell level; their journey as CTC microemboli; their clinical relevance; their biology with the epithelial-to-mesenchymal transition (EMT); their stem-cell properties; their potential to initiate metastasis at distant sites; their ex vivo expansion; and their escape from the immune system.
    Keywords: R5-920 ; n/a ; FOLFIRINOX ; immunofluorescence imaging ; AR-V7 ; circulating tumour cells ; chemoradioresistance ; CTC-based treatment decisions ; rVAR2 ; immunophenotyping ; immune system ; CellSearch® ; flow cytometry ; clinical trials ; circulating tumor DNA ; synaptophysin ; stem cells ; colorectal cancer ; melanoma ; CTC biology ; platelets ; AR ; CTC capture technology ; castration resistant prostate cancer (CRPC) ; PD-L1 expression ; rovalpituzumab tesirine ; HMB-45 ; thymidylate synthase ; ctDNA ; tumor cell dissemination ; solid cancers ; metastasis ; locally advanced rectal cancer ; miRNA ; epithelial-to-mesenchymal transition (EMT) ; NSCLC ; tumor biomarkers ; tumor stem cells ; circulating tumor cells ; major histocompatibility complex class I (MHCI) ; bone marrow ; heterogeneity ; cerebrospinal liquid biopsy ; fish ; glioma ; in vivo flow cytometry ; colorectal surgery ; CellSearch ; single-cell analysis ; disseminated tumor cells ; EasyCount slides ; microsatellite instability ; circulating plasma cells ; circulating leukemia cells ; ARV7 ; SLUG ; androgen receptor ; metastatic colorectal cancer ; leukocyte-derived extracellular vesicles ; prostate cancer (PCa) ; neutrophils ; liquid biopsy ; enzalutamide ; CD133 ; enrichment and detection technologies ; biomarkers ; immune checkpoint inhibitors ; biomarker ; RAD23B ; microbiome ; integrin B1 ; ACCEPT ; emboli ; small-cell lung carcinoma ; EPISPOT ; microfluidics ; early breast cancer ; circulating tumor cells (CTC) ; tumor-initiating cells (TICs) ; immunomodulation ; xenograft models ; CTC-derived xenografts ; malaria ; circulating tumor cells (CTCs) ; clinical utility ; exosomes ; liquid surgery ; ctRNA ; CTCs ; epithelial–mesenchymal transition ; targeted therapy ; hematological cells ; gene expression analysis ; hepatocellular carcinoma (HCC) ; breast cancer ; EpCAM enrichment ; prostate cancer ; CTC ; abiraterone ; fibronectin ; CTC-derived ex vivo models ; CTMat ; chromogranin A ; CTM ; exosome ; bic Book Industry Communication::M Medicine
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  • 17
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The comparison between methods, evaluation of portal hypertension and many other questions are still open issues in liver elastography. New elastographic applications are under evaluation and close to being used in clinical practice. Strain imaging has been incorporated into many disciplines and EFSUMB guidelines are under preparation. More research is necessary for improved evidence for clinical applications in daily practice. The Special Issue published papers on recent advances in development and application of Ultrasound Elastography.
    Keywords: R5-920 ; RM1-950 ; ultrasonography ; elastography ; anti-HBV therapy ; pediatric ; WFUMB ; measurement variability ; tendon stiffness ; pancreas ; patellar positions ; point of care ultrasound ; time of day ; chronic hepatitis B ; quantification ; chronic hepatitis C ; EFSUMB ; stiffness ; liver cirrhosis ; liver fibrosis ; computer-aided diagnosis (CAD) ; guideline ; liver stiffness ; Achilles tendon ; bending energy ; ultrasound elastography ; acoustic radiation force impulse ; tendinopathy ; texture analysis ; power spectrum ; magnetic resonance imaging ; strain ratio ; thyroid cancer ; prior activity ; direct acting antivirals ; strain quantification ; patellar tendon ; shear wave elastography (SWE) ; cine-tagging ; cirrhosis ; health care ; shear wave elastography ; Crohn’s disease ; contrast enhanced ultrasound ; HCV core antigen ; shear modulus ; therapy ; ultrasound ; supersonic shear imaging ; carcinoma ; quantitative ; leg dominance ; viral hepatitis C ; strain elastography ; endoscopic ultrasound (EUS) ; bic Book Industry Communication::M Medicine
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  • 18
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is the definitive reference regarding the global status of melioidosis in 2018. Melioidosis is one of the most neglected tropical diseases (NTDs), so much so that it is not even included in the WHO list of NTDs. Yet modeling suggests that it kills more people worldwide every year than diseases that are much better known, such as leptospirosis and dengue. The reasons for this under-recognition are numerous, including the fact that it mainly affects the disadvantaged rural poor in areas that are poorly supplied with the diagnostic capability to make the diagnosis. In 22 separate articles, expert authors from around the world have summarized what is known about the burden of the disease in humans and animals and the presence of the causative bacterium in the environment in their countries or regions. They have also identified the main obstacles and challenges to establishing the true burden, and to ensure that patients receive accurate diagnosis and optimal care for this all too frequently fatal disease. Rather than focusing on the theoretical risk of the use of Burkholderia pseudomallei as a biological weapon, this book highlights its importance as a clear and present danger to global public health.
    Keywords: R5-920 ; RC955-962 ; South America ; Papua New Guinea ; Cambodia ; Laos ; prevention ; environmental ; Seychelles ; Africa ; India ; Lao PDR ; western Indian Ocean ; animal ; treatment ; Hong Kong ; transmission modes ; Madagascar ; Thailand ; Middle East ; bacteriology ; Vietnam ; public awareness ; Burkholderia ; MLST ; Sri Lanka ; melioidosis ; veterinary ; South Asia ; mortality ; Caribbean ; Australia ; Central America ; Myanmar ; Malaysia ; awareness ; Réunion ; diagnosis ; Mauritius ; Melioidosis ; clinical ; tropical medicine ; B. pseudomallei ; Singapore ; Oceania ; epidemiology ; China ; genomics ; Burkholderia pseudomallei ; surveillance ; Philippines ; environment ; Bangladesh ; Mexico ; Indonesia ; bic Book Industry Communication::M Medicine
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  • 19
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Sleep-related symptoms are common in the majority of psychiatric diagnostic categories. The overlap of sleep and psychiatric disorders have been demonstrated in numerous studies. The understanding of sleep and child psychiatry has progressively evolved in the last decade and newer insights have developed regarding the complex interaction between sleep and psychopathology. This collection of articles represents updates on sleep and psychiatric disorders with medical and neurological co-morbidities in children and adolescents.
    Keywords: R5-920 ; RJ1-570 ; screening ; attention deficit hyperactivity disorder ; medical education ; sleep disturbance ; narcolepsy ; mental health ; circadian disturbance ; schizophrenia ; teenagers ; psychosis ; sleep disorders in ASD ; pediatric sleep ; executive functions ; children ; autism spectrum disorder ; multidisciplinary ; adolescents ; traumatic brain injury ; sleep problems ; comorbidities in ASD ; anxiety ; adolescence ; pediatric intensive care unit ; adolescent ; attention deficit disorder ; Theory of Mind ; arousal ; social functioning ; sleep–wake disorders ; mechanical ventilation ; child psychiatry ; learning ; Acute illness ; non-pharmacologic management ; sedation ; sleep ; electroencephalography (EEG) ; delayed sleep phase ; anticipatory guidance ; behavior ; obstructive sleep apnea ; medications for sleep disorders in ASD ; Attention Deficit Hyperactivity Disorder (ADHD) ; cannabis ; autism ; insomnia ; interventions ; sleep disordered breathing ; emotional information processing cognition ; attention ; cognitive behavioral therapy for insomnia (CBT-I) ; depression ; post-traumatic stress ; melatonin ; psychiatric disorders ; bic Book Industry Communication::M Medicine
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  • 20
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Over the last few years, polyphenol has received a great deal of attention due to their potential beneficial effects on human health. Widely contained in foods commonly consumed in all populations worldwide, polyphenols represent an attractive explanation of the beneficial effects, not only of fruits and vegetables, characteristic components of healthy dietary patterns, but also of other plant-derived foods, such as tea, coffee, and cocoa, which only recently have been exploited as being beneficial for humans. In addition to the numerous biological properties, polyphenols have been indicated as being responsible for a decreased risk of metabolic disorders, cardiovascular disease, and certain cancers. The book addresses original research and reviews of literature concerning polyphenol-rich foods and human health.
    Keywords: R5-920 ; polyphenols ; antioxidants ; inflammation ; prevention of non-communicable diseases ; flavonoids ; bic Book Industry Communication::M Medicine
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  • 21
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The book “Protective and Detrimental Role of Heme Oxygenase-1”, includes a selection of original research papers and reviews aimed at understanding the dual role (protective and detrimental) of HO-1 and the involved signaling pathways. Original research papers and reviews aimed at the identification of natural molecules or new synthetic compounds able to modulate HO-1 activity/expression help make HO-1 a potential therapeutic target for the amelioration of various diseases.
    Keywords: R5-920 ; RM1-950 ; coronary artery disease ; n/a ; glucocorticoid receptor ; antigen presentation ; analgesia ; chemotherapy ; locus coeruleus ; Sirtuin 1 ; thiol groups ; Heme Oxygenase-1 ; Betula etnensis Raf. ; heme oxygenase 1 ; tolerance ; heme oxygenase ; atherosclerosis ; nitric oxide ; caloric restriction ; liver ; carbon monoxide ; ER stress ; heme oxygenase-1 ; mineralocorticoid receptor ; Type 1 diabetes mellitus (T1D) ; Gamma-Glutamyl-Cysteine Ligase (GGCL) ; angiotensin II ; bilirubin ; Heme oxygenase-1 (HO-1) inducers ; Inducible nitric oxide synthase (iNOS) ; HO-1 activity inhibitor ; ferroptosis ; Myristica fragrans kernels ; glutathione ; high-pressure gas ; apoptosis ; HO-1 ; diabetes mellitus ; Caffeic acid phenethyl ester (CAPE) ; carotid plaque ; ischemia–reperfusion injury ; ANTIGEN presenting cell ; LPS ; endoplasmic reticulum stress ; hemoglobin ; Pancreatic oxidative damage ; Colon cancer ; inflammation ; reactive oxygen species ; inflammatory pain ; paracetamol ; cardiomyopathy ; heme oxigenase-1 ; adipocytes ; sirtuin 1 ; peripheral artery disease ; PGC-1? ; heme ; Reactive oxygen species (ROS) ; metformin ; GR ; prostate cancer ; NF-?B ; hyperbilirubinemia ; iron ; Tet-ON system ; lung preservation ; oxidative stress ; Gunn rats ; Dimethylarginine dimethylaminohydrolase-1 (DDAH-1) ; bic Book Industry Communication::M Medicine
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  • 22
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In the post-genomic era, many efforts have been devoted to better understanding the biological information encoded by the cell “glycome” in normal and pathologic conditions. The glycan signature of human cells plays a pivotal role in regulating fundamental biological processes, which are critical for cell physiology and for cancer as well. Galectins (also worded S-type lectins) are an evolutionarily conserved family of endogenous lectins, which bind carbohydrates with high specificity. These molecules, which can be found both intracellularly and in the extracellular milieu, are functionally active in converting glycan-containing information into cell biological programs. This fashionable mechanism of signal transduction plays a relevant role in regulating several biological functions, including RNA splicing, gene transcription, cell migration and differentiation, apoptosis, immune response, and tumor growth and progression. It is not surprising, indeed, that a large number of studies on galectin–glycan interactions and galectins expression and function in human diseases have been published in the recent literature, spanning from immunology to cardiovascular medicine, from diagnostic Pathology to nuclear medicine. The aim of this Special Issue of IJMS is to collect selected contributions in the field reporting data, concepts, and new ideas, which have the potential to be translated in a clinical setting in the near future, in order to improve the diagnosis and treatment of cancer and other relevant human diseases.
    Keywords: R5-920 ; QH301-705.5 ; RM1-950 ; galectins in therapy ; galectins and cancer ; galectins ; galectin-8 ; galectin-9 ; galectins in diagnosis ; galectins and immunity ; galectins and human diseases ; galectin-3 ; galectin-1 ; bic Book Industry Communication::M Medicine
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  • 23
    Publication Date: 2023-12-21
    Description: Antioxidative polyphenols represented by tannins and flavonoids are rich in numerous food sources and traditional natural medicines and currently attracting increased attention in health care and food industries because of their multiple biological activities that are favorable to human health. Commemorating the outstanding achievements on tannins by Dr. Takuo Okuda on the occasion of his passing away in December 2016, his colleagues, friends, and worldwide experts of polyphenol research have contributed 18 papers on their recent study to the Special Issue of Molecules. This book is its reprinted form. This covers reviews of structural features, historical usages, and biological activities of unique class of ellagitannins and condensed tannins, and original articles on the most up-to-date findings on the anticancer effect of green tea catechins, the antivirus effect of tannins comparing with the clinically used drugs, the analytical method of ellagitannins using quantitative NMR, the chemical structures of Hydrangea-blue complex (pigment) and condensed tannins in Ephedra sinica and purple prairie clover, and the relationship of condensed tannins in legumes and grape-marc with methane production in the in vitro ruminant system, and others. This book will be useful to natural product chemists and also to researchers in pharmaceutical and/or food industry.
    Keywords: R5-920 ; Coreopsis lanceolata L. ; UV-Vis ; methanogenesis ; Lythraceae ; flavanone ; grape marc ; TDDFT ; Ephedra sinica ; macrocyclic oligomer ; triple-negative breast cancer ; antioxidant ; purple prairie clover ; chalcone ; neuraminidase ; fatty acid synthase ; (?)-epigallocatechin gallate ; epidermal growth factor ; NMR spectroscopy ; Aluminum ion ; Onagraceae ; Hydrangea macrophylla ; synthetic analogues ; blue color development ; amyloid-? peptide ; FTIR ; oseltamivir carboxylate ; quantitative NMR ; phloroglucinolysis ; thin layer chromatography ; European historic leathers ; FASN inhibition ; ECD ; colorimetric tests ; taxanes ; cynandione A ; conservation method ; 5-O-caffeoylquinic acid ; ellagitannin ; PC12 ; condensed tannin ; Trapa taiwanensis Nakai ; 1H-NMR ; Acacia ; (?)-epigallocatechin 3-gallate ; Geranium thunbergii ; condensed tannins ; immunomodulatory effect ; Acacia mearnsii bark ; Escherichia coli ; oligomer ; Horner–Wadsworth–Emmons reaction ; lung tumor ; Aspergillus fumigates ; in vitro batch fermentation ; metal complex ; Myrtaceae ; Cynanchum auriculatum ; molecular interactions ; phenolic glycoside ; bamboo leaf extract ; stability ; Microsporum canis ; Cynanchum wilfordii ; thiolysis ; anti-inflammation ; hydrolysable tannin ; geraniin ; NGF ; polyphenol ; revision ; ESI-mass ; bioactivity ; antifungal activities ; interferon-? ; antitumor effect ; tannin composition ; oenothein B ; zanamivir ; 2-O-?-laminaribiosyl-4-hydroxyacetophenone ; anticancer activity ; proanthocyanidin ; vegetable tanning ; Dittrichia viscosa ; differentiation ; aurone ; antioxidants ; protein precipitation ; apoptosis ; polyphenolic FASN inhibitors ; forage legume ; biological activities ; ultrahigh-resolution negative mode MALDI-TOF mass spectrometry ; overlay method ; spectroscopy ; wattle tannin ; immune checkpoint ; hormesis ; 3-O-glucosyldelphinidin ; gallotannin ; proanthocyanidins ; fatty acids ; flavonol ; inhibition ; structure ; Candida spp. ; Malassezia spp. ; ORAC assay ; neuroprotection ; crystal structure ; tannins ; bic Book Industry Communication::M Medicine
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  • 24
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The role of nutrition in health and disease has been appreciated from time immemorial. Around 400 B.C., Hippocrates wrote “Let food by thy medicine and medicine be thy food.” In the 12th century, the great philosopher and physician Moses Maimonides wrote “any disease that can be treated by diet should be treated by no other means.” Now, in the 21st century, we are bombarded by claims in the media of “superfoods,” wondrous nutritional supplements, and special diets that promise to cure or prevent disease, improve health and restore functioning. Much of the focus has been on neurological disease, brain health and psychological functioning (behavior, cognition, and emotion). The hyperbole aside, there has been considerable progress in the past decade in our understanding of the contribution of specific nutrients and dietary patterns to brain development, physiology, and functioning. This Special Issue of Brain Sciences is devoted to the latest research on the role of nutritional deficiencies and excesses in the genesis of brain dysfunction, and use of diet for the prevention and treatment of brain and mental disorders. Basic laboratory and clinical research studies of the immature, adult, and aged nervous system are all welcome.
    Keywords: R5-920 ; RC321-571 ; epilepsy ; glioblastoma multiforme ; ADHD ; n/a ; prefrontal cortex ; regainers ; functional neuroimaging ; malignant glioma ; nutrients ; caffeine ; children ; inflammation ; working memory ; cytokines ; modified Atkins diet ; fish intake ; insulin resistance ; transpulmonary administration ; obesity ; maintainers ; electroencephalography ; Alzheimer’s disease ; omega-3 fatty acids ; diet-deficient ; weight loss maintenance ; neural processing ; hippocampal neurogenesis ; bic Book Industry Communication::M Medicine
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  • 25
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Almost 25 years ago, the first mammalian transient receptor potential (TRP) channel was cloned and published. TRP channels now represent an extended family of 28 members fulfilling multiple roles in the living organism. Identified functions include control of body temperature, transmitter release, mineral homeostasis, chemical sensing, and survival mechanisms in a challenging environment. The TRP channel superfamily covers six families: TRPC with C for “canonical”, TRPA with A for “ankyrin”, TRPM with M for “melastatin”, TRPML with ML for “mucolipidin”, TRPP with P for “polycystin”, and TRPV with V for “vanilloid”. Over the last few years, new findings on TRP channels have confirmed their exceptional function as cellular sensors and effectors. This Special Book features a collection of 8 reviews and 7 original articles published in “Cells” summarizing the current state-of-the-art on TRP channel research, with a main focus on TRP channel activation, their physiological and pathophysiological function, and their roles as pharmacological targets for future therapeutic options.
    Keywords: R5-920 ; n/a ; transient receptor potential channels ; photochromic ligands ; elementary immunology ; Purkinje cell ; EPSC ; substance P ; chemicals ; organ toxicity ; lymphocytes ; HSP70 ; physiology ; bioavailable ; inflammatory bowel disease ; platelets ; pollutants ; yeast ; regulatory T cells ; kinase ; Saccharomyces cerevisiae ; manganese ; cerebellum ; TRP channel ; NHERF ; inflammation ; nanoHPLC-ESI MS/MS ; TRPM7 ; chemical probes ; TRPM8 ; dorsal column nuclei ; TRPV2 ; TRPV3 ; calcitonin gene-related peptide ; TRPV1 ; ion channels ; transient receptor potential ; 2D gel electrophoresis ; MALDI-TOF MS(/MS) ; TRPV4 ; overproduction ; sulfur mustard ; oxidative stress ; graft versus host disease ; menthol ; topical ; chemosensor ; AP18 ; calcium signalling ; mucosal epithelium ; cuneate nucleus ; production platform ; TRPC channels ; ulcerative colitis ; channel structure ; xerostomia ; neutrophils ; cardiovascular system ; TRPC5 ; TRPC6 ; TRPC3 ; TRPC4 ; calcium signaling ; protein purification ; adipose tissue ; transient receptor potential (TRP) channels ; sodium ; TH17 ; diacylglycerol ; hypersensitivity ; TRPY1 ; GABAB ; HEK293 ; thrombosis ; ion channel ; TRPC ; pathophysiology ; SMAD ; toxicology ; endothelium ; calcium ; proteomics ; TRPA1 ; salivary glands ; TRP channels ; lipid mediators ; sensors ; radiation ; TRPM4 channel ; human medulla oblongata ; mGluR1 ; small molecules ; TRPC3 pharmacology ; bic Book Industry Communication::M Medicine
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  • 26
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Identification and development of cancer biomarkers and targets have greatly accelerated progress towards precision medicine in oncology. Studies of tumor biology have not only provided insights into the mechanisms underlying carcinogenesis, but also led to discovery of molecules that have been developed into cancer biomarkers and targets. Multi-platforms for molecular characterization of tumors using next-generation genomic sequencing, immunohistochemistry, in situ hybridization, and blood-based biopsies have greatly expanded the portfolio of potential biomarkers and targets. These cancer biomarkers have been developed for diagnosis, early detection, prognosis, and prediction of treatment response. The molecular targets have been exploited for anti-cancer therapy and delivery of therapeutic agents. This Special Issue of Biomedicines focuses on recent advances in the discovery, characterization, translation, and clinical application of cancer biomarkers and targets in malignant diseases of the digestive system. The goal is to stimulate basic and translational research and clinical collaboration in this exciting field with the hope of developing strategies for prevention and early detection/diagnosis of cancer in digestive organs, and improving therapeutic and psychosocial outcomes in patients with these malignant diseases.
    Keywords: R5-920 ; n/a ; liver graft injury ; HFE ; neurokinin ; chemotherapy ; intestinal tumors ; therapeutic targets ; biliary tract carcinoma ; hepatocellular carcinoma ; clinical trial ; cell adhesion molecules ; colorectal cancer ; biomarkers ; phenotypic mosaics ; gastrointestinal oncology ; Asian Cancer Research Group (ACRG) ; biomarker ; psychosocial support ; precision therapy ; pancreatic carcinoma ; precision medicine ; Liver transplantation ; predictive biomarkers ; CD274 ; cholecystokinin ; The Cancer Genome Atlas (TCGA) ; gastrin ; pembrolizumab ; immunotherapy ; gastrin-releasing peptide ; stereotactic body radiation therapy ; immunohistochemistry ; gastric carcinoma ; liver transplant ; CAM invasion assay ; intragraft gene expression profiles ; molecular profiling ; targeted therapy ; neurotensin ; intestinal disorder ; ramucirumab ; next-generation sequencing ; colorectal carcinoma ; tumor progenitor ; circulating tumor cells ; gastrointestinal malignancies ; bombesin ; trastuzumab ; somatostatin ; zebrafish ; G protein–coupled receptors ; bic Book Industry Communication::M Medicine
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  • 27
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The deficits of mammography and the potential of noninvasive diagnostic testing using circulating miRNA profiles are presented in our first review article. Exosomes are important in the transfer of genetic information. The current knowledge on exosome-associated DNAs and on vesicle-associated DNAs and their role in pregnancy-related complications is presented in the next article. The major obstacle is the lack of a standardized technique for the isolation and measurement of exosomes. One review has summarized the latest results on cell-free nucleic acids in inflammatory bowel disease (IBD). Despite the extensive research, the etiology and exact pathogenesis are still unclear, although similarity to the cell-free ribonucleic acids (cfRNAs) observed in other autoimmune diseases seems to be relevant in IBD. Liquid biopsy is a useful tool for the differentiation of leiomyomas and sarcomas in the corpus uteri. One manuscript has collected the most important knowledge of mesenchymal uterine tumors and shows the benefits of noninvasive sampling. Microchimerism has also recently become a hot topic. It is discussed in the context of various forms of transplantation and transplantation-related advanced therapies, the available cell-free nucleic acid (cfNA) markers, and the detection platforms that have been introduced. Ovarian cancer is one of the leading serious malignancies among women, with a high incidence of mortality; the introduction of new noninvasive diagnostic markers could help in its early detection and treatment monitoring. Epigenetic regulation is very important during the development of diseases and drug resistance. Methylation changes are important signs during ovarian cancer development, and it seems that the CDH1 gene is a potential candidate for being a noninvasive biomarker in the diagnosis of ovarian cancer. Preeclampsia is a mysterious disease—despite intensive research, the exact details of its development are unknown. It seems that cell-free nucleic acids could serve as biomarkers for the early detection of this disease. Three research papers deal with the prenatal application of cfDNA. Copy number variants (CNVs) are important subjects for the study of human genome variations, as CNVs can contribute to population diversity and human genetic diseases. These are useful in NIPT as a source of population specific data. The reliability of NIPT depends on the accurate estimation of fetal fraction. Improvement in the success rate of in vitro fertilization (IVF) and embryo transfer (ET) is an important goal. The measurement of embryo-specific small noncoding RNAs in culture media could improve the efficiency of ET.
    Keywords: R5-920 ; n/a ; screening ; single nucleotide polymorphism ; predictive and preventive approach ; PTEN ; cell-free DNAs ; fetal fraction ; gestational hypertension ; RASSF1 ; CDH1 ; RT-PCR ; cfDNA ; statistical models ; hematopoietic stem cell transplantation ; NanoString ; solid organ transplantation ; copy number variants ; sarcomas ; liquid biopsy ; obesity ; fetal DNA ; neutrophil extracellular traps ; mammography ; non-invasive prenatal testing ; ovarian cancer ; circulating miRNA ; pyrosequencing ; growth retardation ; preeclampsia ; gestational diabetes mellitus ; biomarker ; inflammatory bowel disease ; multi-level diagnostics ; PAX1 ; population study ; nuclease activity ; NETosis ; omics ; piRNA ; cell-free DNA ; prediction ; leiomyosarcomas ; network analysis ; NGS ; statistical methods ; circulating nucleic acids ; deletion/insertion polymorphism ; gender differences ; leiomyomas ; fetal growth restriction ; blood plasma ; exosomes ; miRNA ; pregnancy-related complications ; NIPT ; genetic marker ; cell-free nucleic acids ; extracellular vesicles ; expression ; next generation sequencing ; breast cancer ; individualized patient profile ; circulating tumor cells ; maternal serum screening ; personalized medicine ; embryo culture medium ; C19MC microRNA ; DNA ; cell-free RNAs ; z-score ; fetal cells ; microchimerism ; aging ; plasma ; bic Book Industry Communication::M Medicine
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  • 28
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Stroke, a progressively non-communicable disease, is the second leading cause of death after coronary heart disease in developed countries. The present treatment options for stroke are adapting lifestyle practices, diabetes treatment, drugs, and the management of other factors, but no cure is yet available, despite new insights into molecular and therapeutic targets. Discoveries related to explicating the molecular pharmacology in cerebrovascular function and thrombosis have led to significant advancements in the current treatment paradigm for patients with stroke. Hence, this Special Issue invited scientific papers and reviews from researchers to provide solid evidence from a molecular point of view to scrutinize the molecular pharmacology and pathology of strokes. Platelet activation plays a major role in cardio and cerebrovascular diseases. Platelets also play a key role in the hemostatic process and are associated with various pathological events, such as arterial thrombosis and atherosclerosis. While the currently used anti-platelet drugs such as aspirin and clopidogrel demonstrate efficacy in many patients, they exert undesirable side effects. Therefore, the development of effective therapeutic strategies for the prevention and treatment of thrombotic diseases is a significant priority. Recently, precious metal drugs have conquered the subject of metal-based drugs, and several investigators have moved their attention to the synthesis of various ruthenium (Ru) and iridium (Ir) complexes due to their prospective therapeutic values. We have published this e-book about the “Molecular Pharmacology and Pathology of Strokes” and anticipate that readers will find this book useful regarding the significant challenges and current advances that are presently being made in stroke research, with the possibility of inspiring the application of novel drug development to enrich the devotion and treatment of patients with cardiovascular diseases.
    Keywords: R5-920 ; RM1-950 ; RC666-701 ; Neuroprotection ; Vascular diseases ; Novel drug development ; Signal transductions ; Clinical and translational research ; Free radicals/oxidative stress ; Platelet activation and thrombosis ; bic Book Industry Communication::M Medicine
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  • 29
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The goal of this Special Issue, “Probiotics and Prebiotics in Pediatrics”, is to focus on the importance of pediatric nutrition with probiotics and prebiotics to improve gastrointestinal health in newborn, infants, and children.Specifically, the aim is to clarify if probiotics and prebiotics can influence gut microbiota composition and host-interaction favoring human health and preventing diseases.This new information will provide health care professionals with a widespread, clear and update evidence on probiotics and prebiotics and intestinal gut microbiota in pediatric care.
    Keywords: R5-920 ; RJ1-570 ; non-IgE mediated allergy ; n/a ; randomized controlled trials ; infant ; “Probiotics”[Mesh] ; children ; safety ; therapeutic microbiology ; zinc ; prevention ; Lactobacillus ; cow’s milk protein ; constipation ; hepcidin ; infants ; Bifidobacterium ; Bifidobacterium breve ; allergy ; asthma ; functional abdominal pain disorders ; probiotic strain ; formula feeding ; probiotic ; nutritional programming ; 2?-fucosyllactose ; “Pregnancy”[Mesh] ; colic ; iron absorption ; bifidobacteria ; Newborn”[Mesh] ; breast feeding ; neonatal ; diversity ; acute diarrhea ; celiac disease ; human milk oligosaccharide ; acute gastroenteritis ; human milk oligosaccharides ; tolerance acquisition ; iron deficiency anemia ; infantile colic ; Lacto-N-neotetraose ; gluten free diet ; oligosaccharides ; preterm ; preterm infant ; microbial programming ; paediatrics ; Lactobacillus reuteri ; functional constipation ; protein hydrolyzed formulas ; oral rehydration solution ; gluten-free diet ; infant formula ; prebiotic ; Childhood Asthma Control Test ; microbiome ; intestinal transit time ; prebiotics ; sepsis ; probiotics ; microbiota ; “Infant ; lactobacilli ; human milk ; functional gastrointestinal disorders ; inulin ; fecal microbiota ; Bacillus clausii ; peak expiratory flow rate ; breast milk ; immunoglobulin E ; efficacy ; intestinal microbiota ; necrotizing enterocolitis ; pediatrics ; growth ; bic Book Industry Communication::M Medicine
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  • 30
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: With cardiometabolic diseases still topping the list of mortality causes and in facing the obesity and diabetes epidemic, there remains a great need to better understand the pathophysiological derangements underlying these conditions. During the past years, it has become increasingly appreciated that low grade systemic inflammation is a common hallmark of cardiometabolic disorders—not only concerning diabetes and atherosclerotic cardiovascular disease but also involving non-alcoholic fatty liver disease. Recently developed high-throughput laboratory techniques for lipidomics and metabolomics have enabled researchers to discern novel crosstalk pathways between lipid phenotypes and enhanced chronic inflammation. With this Special Issue of the Journal of Clinical Medicine, entitled “Novel Aspects of Lipoprotein Metabolism with a Focus on Systemic Inflammation”, researchers were invited to submit original papers and reviews on various topics, in particular, at the interface of lipid metabolism and inflammation.
    Keywords: R5-920 ; lipids ; atherothrombosis ; interleukin 1? ; hepatic steatosis index ; cholesterol ; cytokines ; small LDL ; anti-apolipoprotein A-1 antibodies ; lipoproteins ; miR-33a ; microparticles ; microvesicles ; platelets ; chronic kidney disease ; endothelial cells ; sodium intake ; lipid metabolism ; HDL function ; GlycA ; acute coronary syndrome ; passive diffusion ; inflammation ; metabolic disorder ; type 2 diabetes mellitus ; leukocytes ; autoantibodies ; cardiovascular disease ; GRACE score ; Breast cancer ; triglycerides ; prognosis ; fatty liver index ; gut microbiota ; paraoxonase-1 ; canakinumab ; carbamoylation ; anti-apolipoprotein A-1 IgG ; 27-hydroxycholesterol ; C-reactive protein ; cholesterol homeostasis ; lipoprotein subfractions ; CANTOS ; myocardial infarction ; diabetic cardiomyopathy ; Type 2 diabetes mellitus ; retinol ; anti-apolipoprotein A-I autoantibodies ; non-alcoholic fatty liver ; large VLDL ; familial hypercholesterolemia ; lipoprotein metabolism ; free thiols ; phospholipid transfer protein activity ; obesity ; foam cells ; cardiovascular events ; atherosclerotic cardiovascular disease (ASCVD) ; biomarkers ; cholesterol-lowering therapies ; trimethylamine N-oxide related metabolites ; adipose tissue ; nuclear magnetic resonance spectroscopy ; biomarker ; metabolic syndrome ; HOMA-IR ; ANGPTL8 ; ANGPTL3 ; ANGPTL4 ; anti-apoA-1 IgG ; adiponectin ; retinol binding protein 4 ; HDL ; TLR2/4 ; visceral adipose tissue (VAT) ; LDL ; renal transplant recipient ; insulin resistance ; infrared spectroscopy ; C-statistics ; large very low density lipoproteins ; cholesterol efflux capacity ; coronary artery calcium score ; betaine ; LDL cholesterol ; bic Book Industry Communication::M Medicine
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  • 31
    Publication Date: 2023-12-21
    Description: This Special Issue has been introduced with the aim of offering the possibility to publish new research results from old and new pioneers in the field of bladder cancer basic research. While editing this Special Issue we learned that an enormous enthusiasm is necessary to go on in bladder cancer research. In our eyes, bladder cancer is on one hand a very heterogenous malignancy, which is what makes it so difficult to focus on only one bladder cancer marker in bladder cancer diagnostics and follow-up. On the other hand, it is very important to find prognostic and predictive factors for bladder cancer due to its high incidence and its enormous costs, as one of the most expensive malignancies in the world. Finding and developing new bladder cancer markers is still a very dynamic field. Because there are many of these markers, it is impossible to report all of them. This Special Issue attempts to highlight the role of bladder cancer markers in diagnosis, and the most important biomarkers that have been recently studied and reported. This Special Issue highlights some of the most important markers. Further determination of recurrence and progression markers will contribute to establishing better treatments for individual patients. Molecular staging of urological tumors will allow the selection of cases that will require systemic treatment. It is necessary and important to integrate basic and clinical research under the same objectives.
    Keywords: R5-920 ; RM1-950 ; RC870-923 ; RB1-214 ; molecular biology ; diagnostics ; tumor markers ; Bladder cancer ; bic Book Industry Communication::M Medicine
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  • 32
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Marine herbal medicine generally refers to the use of marine plants as original materials to develop crude drugs, or for other medical purposes. The term ‘marine plants’ usually denotes macroalgae grown between intertidal and subintertidal zones, including Chlorophyta, Phaeophyta, and Rhodophyta. Considerable progress has been made in the field of biomedical research into marine microalgae and microorganisms in the past decade. As the most important source of fundamental products in the world, marine plants have a very important role in biomedical research. Furthermore, worldwide studies have consistently demonstrated that many crude drugs derived from marine plants contain novel ingredients that may benefit health or can be used in the treatment of diseases; some have been developed into health foods, and some even into drugs. It is expected that there are many substances of marine plant origin that will have medical applications in terms of improving human health and are awaiting discovery.〈false,〉In this Special Issue, entitled “Development and Application of Herbal Medicine of Marine Origin”, we will provide a platform for researchers to publish biomedical studies on substances of marine plant origin. We welcome submissions from scientists and academics from across the world.
    Keywords: R5-920 ; marine functional foods ; vascular endothelial growth factor receptor-3 ; ultrafiltration ; lung fibrosis ; metabolic instability ; peptide fractions ; cembrane ; 3T3 fibroblasts ; Pinnigorgia sp. ; lymphatic endothelial cells ; bile salts ; caspase-3 ; cytokine ; hepatic stellate cells ; macrophage ; oral squamous cell carcinoma ; anti-inflammation ; MAPK ; fucoidan ; Jaspine B ; ACE-inhibition ; bioactivity ; sulfated galactan ; bioavailability ; ROS ; anti-angiogenesis ; briarellin ; neolignan ; radiation pneumonitis ; Pachyclavularia ; Lumnitzera racemosa ; apoptosis ; phomaketide A ; prodigiosin ; neutrophil ; intestinal permeability ; autophage ; secosterol ; octocoral ; amino acids composition ; phlorotannins ; cardiovascular-health ; antioxidant properties ; marine viva ; green seaweed ; protein enzymatic hydrolysate ; lymphangiogenesis ; edible brown algae ; briarane ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Both chronic and acute infections play a significant role in the pathogenesis and clinical course of chronic obstructive pulmonary disease (COPD) and both cystic fibrosis (CF) and non-CF bronchiectasis. There is also specific evidence that chronic infection, even in the absence of acute infection, has an influence on the manifestations and disease course. The infections found in COPD, CF, and bronchiectasis share a number of clinical similarities, the most striking of which are bacterial persistence despite the use of antibiotics and antibiotic resistance. In the last two decades, the rate of antibiotic resistance has increased dramatically and poses serious threats for patients and public health. There are different reasons for this increase in resistance, but the overuse of antibiotics in the community is certainly the most prominent. On the other hand, the chronic use of antibiotics in chronic diseases like COPD, CF, and bronchiectasis is also potentially associated with an increase in MDR pathogens. During the last decade, a growing interest has been raised in evaluating nontuberculous mycobacteria’s role in chronic respiratory diseases like bronchiectasis.
    Keywords: R5-920 ; RC581-607 ; RM1-950 ; Fungi ; Non-Tuberculous Mycobacteria ; Antibiotics ; Respiratory infections ; Pseudomonas aeruginosa ; Bronchiectasis ; Microbiome ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Current worldwide estimates suggest that approxiamtely 11% of all cancers are caused by viral infections. At present, there are eight viruses that have a strong association with cancer development namely, human papillomavirus, Epstein-Barr virus, Kaposi’s sarcoma-associated herpes virus, human T-cell lymphotrophic virus type I, Merkel cell polyomavirus, hepatitis B and C viruses and human immunodeficiency virus. Some of these viruses and associated cancers, such as human papillomavirus and cervical cancer, are well studied and the causal link between infection and cancer development is established. However, the involvement of these known oncogenic viruses in cancer development at other body sites is not well understood and further study of these viruses continues to highlight novel mechanisms of cellular transformation. Other cancer-associated viruses are only recently discovered, such as Merkel cell polyomavirus, and further work is required to formally prove their role in cancer development. In this Special Issue, we seek to explore novel mechanisms of cellular transformation by oncogenic viruses, the role of viral infection in cancer development in understudied body sites and the potential role of novel viral pathogens in cancer development.
    Keywords: R5-920 ; epidemiology ; post-vaccine ; novel mechanism ; cancer ; tumour virus ; emerging ; undiscovered cancers/viruses ; bic Book Industry Communication::M Medicine
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  • 35
    Publication Date: 2023-12-21
    Description: Natural products are increasingly attracting attention from both basic and applied science. Plant secondary metabolites, especially alkaloids, are receiving interest from a wide range of researchers due to their biological activity. They are produced to protect plants from diseases and herbivores. Therefore, they reveal a toxic activity that affects organisms at various levels of biological organization. A growing amount of research is proving their antimicrobial, antifungal, insecticidal, and anticancer activities. That makes them applicable in various fields from medicine, to pharmacology, veterinary, and toxicology, to crop protection. This Special Issue of Toxins, “Biological Activities of Alkaloids: From Toxicology to Pharmacology"", collects 15 manuscripts describing the ecological, biological, pharmacological, and toxicological effects as well as structural and analytical aspects of plant alkaloids, their mode of action, and possible application in veterinary, medicine, and plant protection. These studies prove the potential for alkaloid application in various areas of science.
    Keywords: R5-920 ; RM1-950 ; leukemia ; n/a ; biodistribution ; glycoalkaloids ; insect heart ; Solanum melongena L. ; antibacterial ; alkaloid ; ?-carboline ; Ovarian cancer ; Chelidonium majus ; secondary metabolites ; lindoldhamine ; livestock ; insect ; chanoclavine ; bisbenzylisoquinoline alkaloid ; cytotoxic activity ; Staphylococcus aureus ; antioxidant ; acid-sensing ion channel subtype 1a ; malonylated form ; HPLC-DAD ; ergot alkaloids ; nociception ; macrophage ; Arecoline ; Macleaya cordata ; antifungal ; neuropathic pain ; Corydalis lutea ; antiviral ; Curine ; lung cancer cells ; lipopolysaccharide ; Epichloë ; Meconopsis cambrica ; Berberis thunbergii ; SRC ; Dicentra spectabilis ; apoptosis ; endophyte ; natural sources ; dehydrocrenatidine ; neutrophil ; EGFR ; anticancer ; solamargine ; berberine ; isoquinoline alkaloids ; natural products ; Radix Aconiti Lateralis preparations ; short-term and long-term usage ; inflammation ; acute toxicity ; Mahonia aquifolia ; Palmatine ; sanguinarine ; Rutidea parviflora ; voltage-gated sodium channels ; cytotoxicity ; toxicology ; malonyl-solamargine ; alkaloids ; acetylcholinesterase ; beetles ; Fumaria officinalis ; antimicrobial activity ; solasonine ; FAK ; plant secondary metabolites ; di-ester diterpenoid alkaloids ; mAchR3 ; subchronic feeding study ; mono-ester diterpenoid alkaloids ; Tenebrio molitor ; Apoptosis ; reproduction ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book presents different articles focused on the role of nutritional properties and/or health-related claims on choice preferences, choice behavior, healthy eating/healthy diet, and the willingness to pay for certain foods.
    Keywords: R5-920 ; allergen ; n/a ; consumer home-test ; cereal grains ; non-communicable diseases ; health information ; trans-fatty acids ; health halo ; Aragón ; nutritional knowledge ; WTP ; Food Neophobia Scale (FNS) ; qualitative ; choice architecture ; plant extract ; organic consumer choices ; loglinear analysis ; exposure time ; purchase intentions ; food labelling ; functional ingredients ; greenhouse gas emissions ; non-communicable disease ; functional food ; food labels ; dietary fiber ; dining environment ; food choices ; changes in quality ; random forest ; local ; labeling ; segmentation ; cluster analysis ; nudging ; policy ; green tea ; United Kingdom ; health ; menu ; perceptions ; nutritional labels ; consumer research ; vitamins ; quantile regression ; nutritional claims ; information ; market success ; red wine ; qualified health claim ; alcohol content ; cross-cultural comparison ; health attitudes ; environmental information ; health consciousness ; nutrition claims ; health claim ; choice experiment ; organic dried strawberries ; emotional eating ; Brexit ; claim ; food choice ; pastries ; nutrition claim ; a discrete choice-based experiment ; trade-offs ; campus ; sustainability ; food neophobia ; nutrition ; lycopene ; nutrient labels ; yoghurt ; claims ; ultra-processed food products ; health claims ; willingness to pay ; changes in prices ; binary logistic regression ; new product development ; carrier foods ; consumer behavior ; college students ; focus groups ; clean labels ; consumer heterogeneity ; consumer ; organic ; consumer choice ; biscuits ; packaging ; label ; portion size ; older adult ; visual appraisal ; willingness to purchase ; experimental auction ; cancer ; consumer preferences ; bic Book Industry Communication::M Medicine
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  • 37
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Marine biotoxins may pose a threat to the human consumption of seafood and seafood products. The increasing global trade and higher demand for seafood products worldwide represents a challenge for food safety authorities, policy makers, food business operators, and the scientific community, in particular, researchers devoted to environmental sciences, toxicology, and analytical chemistry. In addition, due to changes in climate conditions and technological developments, new and emerging marine toxins are being detected in regions where they were previously unknown. This Special Issue highlight studies aiming to the develop detection methods for marine biotoxins for better understanding the dynamics of accumulation/elimination of marine biotoxins and their effects on marine organisms, as well as toxin exposure studies that aim to evaluate the risks associated with the consumption of contaminated seafood.
    Keywords: R5-920 ; RA1190-1270 ; mass mortality ; marine biotoxin ; n/a ; alamethicin ; synergy ; seafood toxin ; patulin ; Paralytic shellfish toxin ; greater blue-ringed octopus ; Alexandrium catenella ; paralytic toxicity ; Ishigaki Island ; depuration ; okadaic acid ; serum biomarker ; ecotoxicological responses ; Hapalochlaena lunulata ; sydowinin A ; purification ; PSP outbreak ; southern Chile ; posterior salivary gland ; saxitoxin ; harmful algal blooms ; gliotoxin ; seafood safety ; uptake ; immunoaffinity column ; Alexandrium ; sydowinol ; chronic exposure ; environmental neurotoxin ; assimilation ; shellfish ; LC-MS ; biotransformation ; Perna viridis ; domoic acid ; fish ; algal toxin ; warming ; tetrodotoxin ; Mesodesma donacium ; combination index ; ultrahigh high performance liquid chromatography tandem mass spectrometry ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book presents some of the state-of-the-art methods for the study of the gastrointestinal variables affecting oral drug absorption. Practical applications of new in vitro release/dissolution methods are presented, as well as in vitro permeability studies to explore segmental differences. The application of MRI methods for the study of colon physiology is presented to illustrate its potential applications in controlled release dosage form design. Some examples of successful in vitro–in vivo correlations show how implementing the gastrointestinal physiological variables in the new in vitro methods can improve the predictions of in vivo drug product performance. The book contains an updated review of the experimental, computational, and in vivo approaches for measuring intestinal permeability.
    Keywords: R5-920 ; RM1-950 ; in vitro dissolution ; microscopy imaging ; modulation ; ionotropic gelation ; laponite ; biowaiver ; beads ; model ; polymer/clay composite ; flow ; bioequivalence ; oral absorption ; curcumin ; P-gp ; liquid–liquid phase separation ; absorption ; large bowel ; dissolution ; Ussing chamber ; swelling ; fimasartan ; volume ; dexketoprofen ; gastrointestinal simulator ; transit ; controlled release formulations ; experimental and computational permeability methods ; magnetic resonance imaging ; GastroPlus™ ; in vitro–in vivo correlation (IVIVC) ; diltiazem ; MRI ; gut ; in vitro systems ; CYP3A4 ; poorly water-soluble drugs ; regional absorption ; intestinal permeability ; butyric acid ; intestinal drug absorption ; gastrointestinal absorption ; Biopharmaceutics Classification System (BCS) ; anti-inflammatory ; in vivo ; colon microbiota ; lipid-based formulations ; in situ single-pass perfusion ; metabolites ; biorelevant media ; fluconazole ; colon delivery ; modeling study ; mathematical modeling ; motility ; gellan gum ; gastrointestinal drug release ; large intestine ; lipolysis ; regional drug absorption ; bic Book Industry Communication::M Medicine
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  • 39
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue Book ""Anti-Photoagaing and Photo-Protective Compounds from Marine Organisms"" is aimed at collecting literature on the below-mentioned keyword topics, which can significantly increase our basic understanding of marine-derived compounds in cosmeceutical product development and increases the value of marine products at the industrial level.
    Keywords: R5-920 ; RM1-950 ; UV-absorbing compound ; lifespan ; oligosaccharides ; mast cells ; AP-1 ; antioxidant activity ; phlorotannin ; pH-thermo stability ; microalgae ; Hizikia fusiforme ; skin-aging ; MAPKs ; bioactive ; Fucofuroeckol-A ; carbohydrates ; antioxidant ; mitochondrial function ; natural ; photoprotection ; anti-inflammation ; keratinocytes ; heme oxygenase-1 ; fucoidan ; marine algae ; Biological Effective Protection Factors (BEPFs) ; 9-cis-?-carotene ; MMP ; radical scavenging activity ; Ecklonia stolonifera ; nuclear factor erythroid 2-related factor 2 ; Drosophila melanogaster ; anti-allergy ; miiuy croaker (Miichthys miiuy) ; UVB ; sunscreen ; mobility ; cosmeceuticals ; collagen hydrolysates ; mycosporine-2-glycine ; scale ; cosmetics ; anti-aging ; anti-protein-glycation activity ; pepsin-soluble collagen (PSC) ; inflammation ; sulfated polysaccharides ; UV- mediated action spectra ; skin health ; anti-oxidation ; ageing ; substances ; low molecular-weight ; cytoprotection ; MMPs ; 5-dihydroxybenzaldehyde ; acid-soluble collagen (ASC) ; marine collagen peptide ; Dunaliella salina ; NF-?B ; mycosporine-like amino acids ; photoprotective ; monosaccharides ; degranulation ; ultraviolet-B ; 3-bromo-4 ; bic Book Industry Communication::M Medicine
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  • 40
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book is a printed edition of the Special Issue Promising Detoxification Strategies to Mitigate Mycotoxins in Food and Feed that was published in Toxins
    Keywords: R5-920 ; RA1190-1270 ; Trichoderma ; n/a ; photodegradation product ; physical decontamination ; growth performance ; toxigenic Fusarium ; curcumin ; mitigation ; Aspergillus flavus ; food and beverage ; ascladiol ; biological control ; antioxidant capability ; trichothecene ; bioprospecting ; turkey ; processing ; chicks ; Sporobolomyces sp. IAM 13481 ; mycotoxins ; epimer ; Tri101 ; enzymes ; neutral electrolyzed water ; antioxidant function ; purification ; ameliorating effects ; aflatoxin-degrading enzyme ; chemical decontamination ; desoxypatulinic acid ; furan rings ; maize ; atmospheric pressure ; biotransformation ; estrogen receptor (ER) ; oxidative stress ; decontamination ; Bacillus shackletonii ; hyssop ; DBD ; degradation ; TQEF-MS/MS ; CYP450 ; enzymatic detoxification ; low temperature plasma ; Fusarium ; AFBO–DNA ; modified mycotoxin ; Bacillus subtilis ANSB060 ; polarity ; thermal treatment ; serum hormones ; mycotoxins mitigation ; mycotoxin ; zearalenone (ZEA) ; cell viability ; detoxification ; patulin ; biodegradation ; interactions ; intracellular and extracellular enzymes ; Bacillus licheniformis CK1 ; deoxynivalenol ; aflatoxins ; aflatoxin B1 ; biological decontamination ; Corylus avellana ; molecular ; Pichia caribbica ; mild technologies ; microbial patulin degradation ; enzyme ; proteomics ; fatty acids ; spores of Ganoderma lucidum ; inhibition ; residue ; food safety ; cold atmospheric pressure plasma technology ; application ; post-weaning female piglets ; laccase ; aflatoxin biodegradation preparation ; Aflatoxin B1 ; microorganism identification ; bic Book Industry Communication::M Medicine
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  • 41
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: In recent years, there has been a steady increase in the publication of papers on the chemistry, biology, and potential clinical uses of marine glycosides. Indeed, more than half of the papers published in this field are less than a decade old. Glycosides have been isolated from species as diverse as algae, fungi, anthozoans, and echinoderms. Even fish of the genus Pardachirus produce glycosides, which they use as shark repellents.〈false,>The major interest in these compounds as potential drugs stems from their broad spectrum of biological effects. They have been shown to have antimicrobial, antifungal, anti-inflammatory, immune modulatory, and anticancer effects. The anticancer effects of marine glycosides include cell cycle suppression, the induction of apoptosis, and the inhibition of migration, invasion, and metastasis, as well as antiangiogenesis. Marine glycosides influence membrane permeability and have been shown to influence membrane transport at the molecular level through effects on transport carriers and pumps, as well as effects on ligand-gated and voltage-gated channels. Various marine glycosides have been shown to activate sphingomyelinase and ceramide synthesis, to inhibit topoisomerase activity, receptor tyrosine kinase activity, and multidrug resistance protein activity, and to antagonize eicosanoid receptors.〈false,>This Special Issue covers the entire scope of marine organism-derived glycosides that are of potential value as pharmaceutical agents or leads. These include, but are not limited to, tetracyclic triterpene glycosides, other triterpene glycosides, steroid glycosides, and glycosides of non-isoprenoid aglycones.
    Keywords: R5-920 ; RM1-950 ; leukemia ; angucycline glycosides ; steroidal glycoside ; antitumor ; deep-sea ; antibacterial ; anticoagulant ; saquayamycin ; marine invertebrate ; triterpene glycoside ; glycosides ; carbohydrate ; polyhydroxysteroidal glycoside ; glycosphingolipids ; triterpene glycosides ; cytotoxic activity ; metabolite profiling ; magnumosides ; antioxidant ; angiogenesis ; Poecillastra compressa ; cucumarioside ; antifungal ; nonholostane ; Eupentacta fraudatrix ; angucycline ; urdamycin ; marine ginseng ; sponge ; antimicrobial ; holostane ; apoptosis ; cholesterol sulfate ; SMMC-7721 ; metastases ; Culcita novaeguineae ; natural products ; marine organisms ; liquid chromatography–tandem mass spectrometry ; anti-inflammatory ; tumor growth ; mass spectrometry ; ESI ; total synthesis ; starfish ; sea cucumber ; cytotoxic ; cytotoxicity ; saponins ; Neothyonidium magnum ; glycolipids ; glycoglycerolipids ; Conus pulicarius ; MALDI ; Streptomyces ; glycoside ; radioactive irradiation ; frondoside A ; LC-MS ; invasion ; Holothuroidea ; saponin ; bioactive compounds ; cancer ; structure elucidation ; mangrove-derived Streptomyces ; bic Book Industry Communication::M Medicine
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  • 42
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [This Special Issue book, “Natural Products for Cancer Prevention and Therapy”, is based on recent advances in natural products for cancer prevention and therapy. For this purpose, the authors of this book have been organizing a biennial international conference series. The first meeting (First International Conference on Natural Products for Cancer Prevention and Therapy) was held in Istanbul between 31 August and 2 September 2015, with the support and contribution of many valuable researchers in this field. The abstracts of the first conference were published in the Anticancer Drugs journal as a supplement. The second meeting, namely The Second International Conference on Natural Products for Cancer Prevention and Therapy, was held at Erciyes University, Kayseri, Turkey, between 8 and 11 November 2017. The abstracts of all of the presentations from the second meeting were published in the Special Issue of Proceedings by the MDPI publishing group. Furthermore, the conference report and the selected full-length papers based on the presentations at the meeting, as well as other papers based on natural products for cancer prevention and therapy, were published as a Special Issue of the Nutrients journal from MDPI. This Special Issue has contributions from various participants of the aforementioned conference, as well as other cancer and natural product researchers. These contributions include original research papers, authoritative and up-to-date reviews, and commentaries on the following topics and areas: •Natural products for the prevention and therapy of oncologic diseases •Mechanism of natural agents for anticancer and cancer preventive effects •In vitro, in vivo, and clinical studies related to natural agents and cancer • Combinatorial effects of phytochemicals and cancer chemotherapeutic drugs •Challenges and innovative approaches for anticancer drug development based on natural products •Emerging studies on anticancer phytochemicals]
    Keywords: R5-920 ; RM1-950 ; RC254-282 ; Phytochemicals ; Natural products ; Cancer therapy ; Dietary agents ; Cancer prevention ; bic Book Industry Communication::M Medicine
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  • 43
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: MicroRNAs (miRNAs) constitute a large family of small, approximately 20–22-nucleotide, non-coding RNAs that are involved in gene regulation, mainly at the post-transcriptional level. Multiple lines of evidence have indicated that miRNAs play important roles in the maintenance of biological homeostasis and that aberrant expression levels of miRNAs are involved in the onset of many diseases, including cancer. In various types of cancer, miRNAs play important roles in tumor initiation and development. Recently, miRNAs have been demonstrated to also be secreted via small endosome-derived vesicles called exosomes—which are derived from multiple cell types—including immunocytes and cancer cells. Exosomal miRNAs exert important functions in cell-to-cell communication and have been investigated as prognostic and diagnostic biomarkers.
    Keywords: R5-920 ; RM1-950 ; RC254-282 ; tumor initiation and development ; cancer therapy ; circulating microRNA ; microRNA ; diagnosis ; biomarker ; exosome ; bic Book Industry Communication::M Medicine
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  • 44
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: [Increasing evidence suggests that microbiota and especially the gut microbiota (the microbes inhabiting the gut including bacteria, archaea, viruses, and fungi) plays a key role in human physiology and pathology. Recent findings indicate how dysbiosis—an imbalance in the composition and organization of microbial populations—could severely impact the development of different medical conditions (from metabolic to mood disorders), providing new insights into the comprehension of diverse diseases, such as IBD, obesity, asthma, autism, stroke, diabetes, and cancer. Given that microbial cells in the gut outnumber host cells, microbiota influences human physiology both functionally and structurally. Microbial metabolites bridge various—even distant—areas of the organism by way of the immune and hormone system. For instance, it is now clear that the mutual interaction between the gastrointestinal tract and the brain (gut–brain axis), often involves gut microbiota, indicating that the crosstalk between the organism and its microbial residents represents a fundamental aspect of both the establishment and maintenance of healthy conditions. Moreover, it is crucial to recognize that beyond the intestinal tract, microbiota populates other host organs and tissues (e.g., skin and oral mucosa). We have edited this eBook with the aim of publishing manuscripts focusing on the impact of microbiota in the development of different diseases and their associated treatments.]
    Keywords: R5-920 ; RC31-1245 ; gastrointestinal diseases ; sterile inflammation ; n/a ; Staphylococcus spp. ; etiopathogenesis ; colitis ; Escherichia coli ; bacteriophages ; atopic dermatitis ; intravenous immunoglobulin G ; adaptive immunity ; 16S rRNA gene ; vaginal microbiota ; modularity ; innate immunity ; gut-liver axis ; disease activity ; immune system ; cytokines ; commensals ; Staphylococcus aureus ; dysbiosis ; fecal transplantation ; TLR mimicry ; etanercept ; dextran sulfate sodium ; CAR T-cell ; 3-dihydroxy-4-methoxyBenzaldehyde ; chemo free treatment ; Staphylococcus epidermis ; rheumatoid arthritis ; microbiome ; co-occurrence network ; immune epigenetics ; 2 ; autoimmunity ; superoxide dismutase ; precision medicine ; metabolism ; adoptive cell transfer (ACT) ; gut barrier ; antibiotics ; checkpoint inhibitors ; probiotics ; microbiota ; Candida albicans ; Enterococcus faecalis ; chronic liver diseases ; TCR ; anaerobic bacteria ; HSV2 ; bacteriocins ; methotrexate ; microbial interactions ; T cells ; virus ; mice ; lymphoid malignancies ; HPV ; macrophages ; anti-TNF-? ; inflammation ; chondroitin sulfate disaccharide ; immunotherapy ; genomics ; immuno-oncology ; diet ; aerobic bacteria ; immunological niche ; melanin ; health ; chemokines ; gut microbiota ; cutaneous immunity ; HIV ; TIL ; cancer ; global network ; bic Book Industry Communication::M Medicine
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  • 45
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Contamination of foods and agricultural commodities by various types of toxigenic fungi is a concerning issue for human and animal health. Moulds naturally present in foods can produce mycotoxins and contaminate foodstuffs under favourable conditions of temperature, relative humidity, pH, and nutrient availability. Mycotoxins are, in general, stable molecules that are difficult to remove from foods once they have been produced. Therefore, the prevention of mycotoxin contamination is one of the main goals of the agriculture and food industries. Chemical control or decontamination techniques may be quite efficient; however, the more sustainable and restricted use of fungicides, the lack of efficiency in some foods, and the consumer demand for chemical-residue-free foods require new approaches to control this hazard. Therefore, food safety demands continued research efforts for exploring new strategies to reduce mycotoxin contamination. This Special Issue contains original contributions and reviews that advance the knowledge about the most current promising approaches to minimize mycotoxin contamination, including biological control agents, phytochemical antifungal compounds, enzyme detoxification, and the use of novel technologies.
    Keywords: R5-920 ; RA1190-1270 ; n/a ; decontamination ; superheated steam ; quercetin glycosides ; antagonism ; mode of action ; corn ; Botrytis sp. ; AITC ; binding ; degradation ; brine shrimp bioassay ; apple pomace ; nanoparticles ; enzymatic detoxification ; Bacillus ; estrogen response element ; Fusarium ; biological detoxification ; abiotic factors ; stability ; fumonisin esterase FumD ; mycotoxigenic fungi ; Aspergillus flavus ; Aflatoxin M1 ; Fusarium graminearum ; milk ; Penicillium digitatum ; biocontrol agents ; biological control ; dry-cured ham ; mycotoxin reduction ; Fusarium sp. ; enzyme kinetics ; Penicillium nordicum ; Satureja montana ; roasted coffee ; fermentation ; crisp biscuit ; detoxification ; essential oils ; gene expression ; probiotics ; zearalenone ; mycotoxins ; degradation products ; Geothrichum citri-aurantii ; garlic-derived extracts ; Zearalenone ; biodegradation ; EU limits ; storage ; Origanum virens ; aflatoxin ; fungal growth reduction ; green chemistry ; Penicillium italicum ; deoxynivalenol ; ?-Fe2O3 ; ochratoxin A (OTA) ; wheat ; cell-free extracts of Aspergillus oryzae ; photocatalysis ; wheat quality ; post-harvest phytopathogen ; cold plasma ; pinnatifidanoside D ; ochratoxin A ; oats ; cell proliferation ; estrogen receptor ; Penicillium verrucosum ; pig production performance ; phloridzin ; maize ; biotransformation ; fumonisin ; fungi ; bic Book Industry Communication::M Medicine
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  • 46
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Once viewed solely as fat storage cells, adipocytes and their adipokines have now been proven to be central for human health. Understanding that overweight and obesity may increase the risk for various diseases requires detailed characterization of adipokine function. Weight gain, weight regain, and fasting affect adipocyte health and accordingly their secretome. Different adipose tissue deposits exist and they vary in cellular composition and function. The evidence is strong of a role of adipokines in cancer, reproductive function, neurological diseases, cardiovascular diseases ,and rheumatoid arthritis. Adipokines are considered useful biomarkers for adipose tissue and metabolic health, and may be used as diagnostic tools in rheumatoid arthritis, cancer, or sepsis. This book contains 10 original articles and 9 review articles focusing on these bioactive peptides. Several articles deal with chemerin, an adipokine discovered more than 20 years ago. Data so far have resulted in promising insights related to its biological function. We are only beginning to understand the multiple roles of chemerin, the mechanisms regulating its activity, and the signaling pathways used by this chemokine. Adipokine receptor agonists and antagonists may result in the formulation of novel drugs and ultimately may lead to new therapeutic targets to be used in clinical practice.
    Keywords: R5-920 ; RM1-950 ; n/a ; lipids ; cathepsins ; neurodegeneration ; tocilizumab ; SGBS adipocytes ; chemerin receptors ; cholesterol ; metabolically healthy obese ; energy metabolism ; adipose-brain axis ; EP3 receptor ; leptin ; rheumatoid arthritis ; excessive gestational weight gain ; in vitro fat regain ; secreted frizzled-related protein 5 ; PCOS ; EP4 receptor ; leukocyte ; exchange protein directly activated by cAMP isoform 2 (EPAC2) ; extracellular remodeling ; insulin ; osteoarthritis ; lipid metabolism ; fat mass ; Tango bioassay ; fatty liver ; free fatty acids ; label-free proteomic profiling ; interleukin(IL)-33 ; sick fat ; polycystic ovary syndrome ; early-life programming ; inflammation ; gestational diabetes ; glucose restriction ; adipokines ; neonatal anthropometry ; epicardial adipose tissue (EAT) ; oestrous cycle ; Cardiovascular Diseases (CVDs) ; triglycerides ; G protein-coupled receptor 1 ; testicular pathologies ; prognosis ; ovary ; ICU ; biologic activity ; preeclempsia ; adipokine ; critical illness ; early pregnancy ; myokine ; liver steatosis ; C-C chemokine receptor-like 2 ; testis ; stimulating growth factor 2 (ST2) ; pig ; fitness ; human granulosa cells ; obesity ; proteolysis ; annexins ; adipose tissue ; biomarker ; ghrelin ; brain health ; sepsis ; adiponectin ; rheumatic diseases ; chemokine-like receptor 1 ; follicular fluid ; glucose homeostasis ; resistin ; Nonalcoholic fatty liver disease ; prostaglandin E2 (PGE2) ; visceral fat ; microglia ; weight regain ; complement factors ; alpha-fetoprotein ; polycystic ovary morphology ; chemerin ; cancer ; depression ; hypertension ; hypothalamus ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Current efforts to limit the ravages of schistosomiasis are pushing the world closer to eliminating a chronic infection that has been associated with human life in the tropics since time immemorial. This notwithstanding, the disease remains a scourge for large populations in sub-Saharan Africa, Latin America, and Southeast Asia, and the main part of this book is made up by papers dealing with its current distribution, discussing ways and means to establish and implement improved control approaches. While chemotherapy limits the symptoms caused by schistosomiasis, the number of infected people will not decrease until the parasite's life cycle is interrupted. To that end, some papers focus on the intermediate snail host, which is notoriously difficult to control, while others discuss human hygiene and sanitation. The latter approach not only prevents infection through avoiding people being infected from the snail, but more importantly, also stops people infecting the snail by leaving contagious feces and urine in nature. With morbidity reduced by chemotherapy, the immediate target now is the interruption of transmission to be achieved by new tools, such as the novel chemotherapies, improved diagnostics (for humans, animals, and snails), and vaccines discussed in several of the papers. As made clear in this book, a complex infection requires new tools as well as work on many fronts, above all; however, a clear idea is needed as to how to skillfully combine the tools available and sustain implemented control activities.
    Keywords: R5-920 ; RC109-216 ; n/a ; Cambodia ; schistosomiasis elimination ; chemotherapy ; Côte d’Ivoire ; systems thinking ; Schistosomiasis mansoni ; control and elimination ; neglected tropical diseases ; drug discovery ; systems epidemiology ; guidelines ; schistosomiasis ; Central Africa ; goals ; mapping ; Africa ; cattle ; zoonosis ; systematic non-compliance ; Lao PDR ; Sm14 ; POC-CCA ; planorbidae ; complexity ; distribution ; remote-sensing ; Neotricula aperta ; sanitation ; Biomphalaria glabrata ; Schistosomiasis ; international space station ; Mayuge ; elimination ; spatio-temporal epidemiology ; goats ; FABP ; artemether ; interdisciplinarity ; praziquantel ; soil-transmitted-helminthiasis ; Caribbean ; health education ; snail ; Schistosoma haematobium ; snail resistance ; 28S ribosomal DNA ; WIPO Re:Search ; intermediate snail host ; Schistosoma malayensis ; Gabon ; transmission ; soil-transmitted helminths ; combination therapy ; S. mansoni ; climate change ; domestic animals ; Schistosoma mansoni ; diagnosis ; Schistosoma japonicum ; leishmaniasis ; modelling ; public-private partnerships ; GIS ; ECOSTRESS ; young adults ; Oncomelania hupensis ; PCR ; Bulinus truncatus ; gene drive ; worldview ; S. japonicum zoonosis ; coverage rate ; phylogeography ; cross-sector collaboration ; epidemiology ; preventive chemotherapy ; MDA coverage ; China ; operational research ; transmission control ; satellite ; high-sensitivity diagnostics ; loop-mediated isothermal amplification (LAMP) ; sheep ; polymerase chain reaction ; BIO Ventures for Global Health ; bovines ; Kato-Katz ; vaccine development ; treatment-opportunities ; Philippines ; buffalo ; Schistosoma mekongi ; control ; Schistosoma ; vector control ; vaccine ; parasite ; Asia ; transgenic snail ; snail control ; DNA ; capacity-building ; Uganda ; pooled samples ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Mucoadhesive polymers are widely used in the design of dosage forms for transmucosal drug delivery to the eye, respiratory, gastrointestinal and reproductive tracts. These routes of drug administration offer a number of advantages including improved drug bioavailability, reduced frequency of administration, and the avoidance for the use of injections.
    Keywords: R5-920 ; RM1-950 ; chitosan ; maltodextrin ; Caco-2 cells ; alkyl lactate ; mucosal drug delivery ; thermogelling polymers ; buccal mucosa drug delivery ; drug delivery ; triple co-culture model ; oral lichen planus ; mucoadhesive polymers ; cyclodextrins ; paediatric ; mucoadhesion ; nanoparticles ; pectin ; furosemide ; oral lyophilisates ; films ; wound healing ; pluronic f127 ; interpolymer complexes ; transmucosal permeations ; Alzheimer’s disease ; biocompatibility ; poly (vinylpyrrolidone) ; mucosal membranes ; scanning electron microscopic images ; pioglitazone ; hydrogel ; resuspendibility ; thermoresponsive polymers ; mucoadhesive microspheres ; trimethyl chitosan ; Candida albicans ; xanthan gum ; omeprazole ; texture profile analysis ; acrylated chitosan ; mucoadhesive ; clotrimazole ; clobetasol ; Carbopol® ; hydroxypropyl cellulose ; electrospinning ; chitosan derivatives ; in vitro permeability ; l-arginine ; resveratrol ; cytotoxicity ; retention ; thiolated hyaluronic acid ; Carbopol ; mucoadhesive polymer ; rheology ; Eudragit® E PO ; detachment force ; chitosan-catechol ; controlled release ; PLGA-PEG ; liposphere ; gellan gum ; storage and loss moduli ; thiolated chitosan ; interpolyelectrolyte complex ; poly(2-ethyl-2-oxazoline) ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: It is with great pleasure that we present to you this Special Issue of Medical Sciences. In this issue, we present a comprehensive and contemporary review of the medical comorbidities that contribute to chronic rhinosinusitis, and, conversely, how our interventions as otolaryngologists can impact those systemic conditions. Our understanding of chronic rhinosinusitis has evolved tremendously over the last two decades. As we have learned, chronic rhinosinusitis—a chronic inflammatory condition of the nasal cavity and paranasal sinuses—is often a local inflammatory response to a systemic or mucosal disorder. The underlying systemic medical conditions not only influence the presentation and diagnosis of chronic rhinosinusitis, but also modify the patients’ response to medical and surgical interventions. Chronic rhinosinusitis associated with cystic fibrosis, for example, is a disorder quite distinct from that associated with aspirin-exacerbated respiratory disease. A clear understanding of the nuances that distinguish these unique and challenging disorders is critical for the practicing otolaryngologist. Equally important, however, is a clear understanding of the powerful benefits that our interventions as otolaryngologists can have for our patients’ rhinologic and systemic health. Knowing that our rhinologic interventions might spare an asthma patient a trip to an emergency room or reduce lung infections in a cystic fibrosis patient makes this a very exciting time to be a rhinologist. We hope you enjoy this Special Issue of Medical Sciences.
    Keywords: R5-920 ; RD1-811 ; n/a ; AERD ; pediatric ; adenoidectomy ; chronic rhino sinusitis ; cystic fibrosis ; biofilm ; nasal polyps ; aspirin exacerbated respiratory disease ; eosinophilia ; eosinophil ; adenoiditis ; nasal poly ; endoscopic sinus surgery ; aspirin desensitization ; central compartment atopic disease ; medial maxillectomy ; allergy ; diagnosis ; adenoids ; asthma ; allergic fungal rhinosinusitis ; nasal polyposis ; Samter’s Triad ; medical management ; sinus surgery ; chronic rhinosinusitis ; sinusitis ; allergic rhinitis ; rhinosinusitis ; polyposis ; hyposmia ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-04-05
    Description: Nanofibers, particularly those of a carbonaceous content, have received increased interest in the past two decades due to their outstanding physico-chemical characteristics and their possibility to form and contribute towards a plethora of potentially advantageous materials for consumer, industrial and medical applications. Despite this, and together with the numerous research studies and published articles that have sought to investigate these aspects, the potential impact of CNTs is still not understood. Whether or not nanofibers may be able to provide a sophisticated alternative to conventional materials is still debatable, whilst their effects upon both environmental and human health are highly equivocal. How nanofibers are conceived can determine how they may interact with different environments, such as the human body. Understanding each key step of the synthesis and production of nanofibers to their use within potential applications is therefore essential in gaining an insight into how they may be perceived by any biological system and environment. Thus, obtaining such information will enable all scientific communities to begin to realize the potential advantages posed by nanofibers. The aim of this Special Issue therefore, was to provide a collective overview of nanofibers; ‘from synthesis to application’. The Issue particularly focuses upon carbon-based nanofibers, but also highlights alternative nanofiber types. Emphasis is given holistically, with articles discussing the production routes of nanofibers, their plight during their life-cycle (origin to applied form and effects over time), as well as how nanofibers could either incite conflict, or provide aid to human and environmental health.
    Keywords: QD1-999 ; Toxicology ; Chemistry ; Biology ; Material Science ; Nanofibers ; Nanotechnology ; thema EDItEUR::P Mathematics and Science::PN Chemistry
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Drug metabolism/pharmacokinetics and drug interaction studies have been extensively carried out in order to secure the druggability and safety of new chemical entities throughout the development of new drugs. Recently, drug metabolism and transport by phase II drug metabolizing enzymes and drug transporters, respectively, as well as phase I drug metabolizing enzymes, have been studied. A combination of biochemical advances in the function and regulation of drug metabolizing enzymes and automated analytical technologies are revolutionizing drug metabolism research. There are also potential drug–drug interactions with co-administered drugs due to inhibition and/or induction of drug metabolic enzymes and drug transporters. In addition, drug interaction studies have been actively performed to develop substrate cocktails that do not interfere with each other and a simultaneous analytical method of substrate drugs and their metabolites using a tandem mass spectrometer. This Special Issue has the aim of highlighting current progress in drug metabolism/pharmacokinetics, drug interactions, and bioanalysis.
    Keywords: R5-920 ; RM1-950 ; human liver microsomes ; alcohol addiction ; UGT ; ultra-high-pressure liquid chromatography ; adalimumab ; procainamide ; LC-MS/MS ; DA-9805 ; paeonol ; LC-QTOF-MS/MS ; YRA-1909 ; chlorogenic acid ; immunoprecipitation ; Eurycoma longifolia ; CYP ; caffeic acid ; rat ; pharmaceutical excipient ; Korean red ginseng extract ; Stauntonia hexaphylla leaf extract ; bioanalysis ; HPLC-MS/MS ; B6 ; eurycomanone ; bioavailability ; drying technology ; GB3 ; diclofenac ; 129-Glatm1Kul/J ; aglycone ; caffeic acid O-glucuronides ; organic anion transporting polypeptide ; protein precipitation ; metabolic stability ; Fabry disease ; biopharmaceuticals ; imperatorin ; neochlorogenic acid ; gastric ulcer ; saikosaponin a ; hair ; anthraquinone ; acetyl tributyl citrate ; pharmacokinetics ; brain distribution ; mematine ; ethyl glucuronide ; pharmacokinetic ; loxoprofen ; liquid chromatography-quadrupole TOF MS ; glucuronidation ; esomeprazole ; metformin ; cytochrome P450 ; glycoside ; AUDIT score ; protein stability ; efficacy ; LC-HR/MS ; cryptochlorogenic acid ; aceclofenac ; drug interaction ; liquid chromatography-tandem mass spectrometry ; Osthenol ; plasma ; N-acetylprocainamide ; diabetes ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This book focuses on the investigation, development, and modernization of acupuncture in basic research settings as well as in clinical applications. The book contains 13 chapters reporting the latest evidence-based results of acupuncture research and exploring acupuncture in general. Altogether, 44 authors from all over the world contributed to this book.
    Keywords: R5-920 ; RM1-950 ; acupuncture ; sciatica ; low back pain (LBP) ; uterine cancer ; osteoarthritis ; myopia ; pulse diagnosis ; depression ; moxibustion ; post-stroke ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: A “genotype"" is essentially an organism's full hereditary information which is obtained from its parents. A ""phenotype"" is an organism's actual observed physical and behavioral properties. These may include traits such as morphology, size, height, eye color, metabolism, etc. One of the pressing challenges in computational and systems biology is genotype-to-phenotype prediction. This is challenging given the amount of data generated by modern Omics technologies. This “Big Data” is so large and complex that traditional data processing applications are not up to the task. Challenges arise in collection, analysis, mining, sharing, transfer, visualization, archiving, and integration of these data. In this Special Issue, there is a focus on the systems-level analysis of Omics data, recent developments in gene ontology annotation, and advances in biological pathways and network biology. The integration of Omics data with clinical and biomedical data using machine learning is explored. This Special Issue covers new methodologies in the context of gene–environment interactions, tissue-specific gene expression, and how external factors or host genetics impact the microbiome.
    Keywords: R5-920 ; RM1-950 ; precision medicine informatics ; n/a ; drug sensitivity ; chromatin modification ; cell lines ; biocuration ; neurodegeneration ; multivariate analysis ; artificial intelligence ; epigenetics ; missing data ; sequencing ; clinical data ; class imbalance ; integrative analytics ; algorithm development for network integration ; deep phenotype ; non-omics data ; feature selection ; Gene Ontology ; miRNA–gene expression networks ; omics data ; plot visualization ; Alzheimer’s disease ; tissue classification ; epidemiological data ; proteomic analysis ; genotype ; RNA expression ; indirect effect ; multi-omics ; dementia ; multiomics integration ; data integration ; phenomics ; network topology analysis ; challenges ; transcriptome ; enrichment analysis ; regulatory genomics ; scalability ; heterogeneous data ; systemic lupus erythematosus ; database ; microtubule-associated protein tau ; disease variants ; genomics ; joint modeling ; distance correlation ; annotation ; phenotype ; direct effect ; curse of dimensionality ; gene–environment interactions ; logic forest ; machine learning ; KEGG pathways ; multivariate causal mediation ; amyloid-beta ; bioinformatics pipelines ; support vector machine ; pharmacogenomics ; candidate genes ; tissue-specific expressed genes ; cognitive impairment ; causal inference ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Rabies is an acute, progressive, incurable viral encephalitis and one of the oldest described infectious diseases. All mammals are susceptible to infection, but rabid dogs are responsible for the greatest global burden. Bats and carnivores are the major wildlife reservoirs. More than 60,000 persons, primarily children, succumb each year after the bite from a rabid animal. This compilation describes new information on disease surveillance, diagnosis, prevention and control within Africa, Eurasia and the New World. Public health professionals, veterinarians, physicians, laboratory workers and conservation biologists should appreciate the novel communications provided from internationally renowned authors and the diversity of topics in this special issue on rabies.
    Keywords: R5-920 ; Infectious disease ; one health ; rabies ; veterinary medicine ; prophylaxis ; virus ; zoonosis ; public health ; vaccination ; wildlife ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: At least 20 million children worldwide would benefit from Pediatric Palliative Care (PPC) annually, and eight million children would need specialized PPC services. In the USA alone, more than 42,000 children, 0–19 years, die annually; fifty-five percent of them are infants younger than one year old. Interdisciplinary PPC is about matching treatment to patient goals and is considered specialized medical care for children with a serious illness. It is focused on relieving pain, distressing symptoms, and stress from a serious illness and is appropriate at any age and at any stage, together with curative treatment. The primary PPC goal is to improve the quality of life both for the child and for his/her family. Sadly, advances in the control of symptoms in children dying of life-limiting diseases have often not kept pace with treatment directed at curing the underlying disease. Data reveal that the majority of distressing symptoms in children with an advanced serious illness (such as pain, dyspnea and nausea/vomiting) are not treated, and, when treated, therapy is commonly ineffective. Emerging evidence shows that palliative care involvement results in improved quality of life, as well as prolongation of life. High-quality pediatric palliative care for children with serious illnesses is now an expected standard of medical care. However, there still remain significant barriers to achieving optimal care, related to lack of formal education, reimbursement issues, the emotional impact of caring for a dying child, and most importantly, the lack of interdisciplinary PPC teams with sufficient staffing. Fortunately, considerable advances have been made in recent years providing PPC around the globe both in resource-poor and resource-rich countries through care provided at children’s hospitals, outpatient palliative care clinics, palliative home care, and free-standing children’s hospice houses. This book, authored by leading authorities in the field, is dedicated to describing existing gaps, as well as the achievements made in clinical care, education, training, and research.
    Keywords: R5-920 ; RJ1-570 ; symptom management ; life-limiting disease ; quality of life ; hospice ; pediatric palliative care ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Presented here are scientific reports which add considerable information to the area of early stage ovarian cancer detection and the application of this detection to ovarian cancer screening. In this volume, the following presentations are made: 1) The performance of different ultrasound-based International Ovarian Tumor Analysis (IOTA) strategies is analyzed to discriminate between early stage ovarian malignancy and benign abnormalities of the ovary. 2) Since oophorectomy confers protection against ovarian cancer, when adjustment for oophorectomy was made, rates of ovarian cancer were substantially higher. 3) The frequency of symptoms relevant to ovarian cancer was found to be more than two-hundred times higher than the occurrence of ovarian cancer and it was found that 80.1% of women expressed confidence in the symptoms they reported. 4) Complications resulting from surgery performed in the Kentucky Ovarian Cancer Screening Program were infrequent and significantly fewer than reported in the Prostate, Lung, Colorectal and Ovarian Cancer Screening trial. Complications observed were mostly minor (93%) and were more common in cancer versus non-cancer surgery. 5) Arguments in favor of serial ultrasonography as an alternative to immediate surgery are presented and illustrate the benefits of surveillance. 6) Ten critical considerations for ovarian cancer screening are presented in depth, highlighting their important bearing on ovarian screening outcomes and their interpretations. 7) Considerations that have psychological and behavioral impacts on individuals participating in ovarian screening suggest that a “normal” screening test result can have psychological benefits, including an increased positive effect and beliefs in the efficacy of screening. 8) The efficacy of ovarian cancer screening may be higher in Asia than in Europe and the USA. Additionally, the re-analysis of PLCO screening data, when cancers presenting more than one year after screening are excluded, shows a significant survival benefit in the PLCO screening trial. 9) The effect that ovarian cancer has on patients and their families is examined from the perspective of a first-year resident in Obstetrics and Gynecology. 10) The 50-year history of biomarkers and ultrasound in the context of ovarian cancer indicates the importance of serial application of both biomarkers and ultrasound. Taken together, this volume provides both original data and overviews of ovarian cancer screening studies that enhance the present interpretation of this type of screening.
    Keywords: R5-920 ; treatment ; collateral affectors ; costs ; screening ; endpoints ; trail design ; ovarian cancer ; efficacy ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Nanomedicine represents one of the most investigated areas in the last two decades in the field of pharmaceutics. Several nanovectors have been developed and a growing number of products have been approved. It is well known that many biomaterials are able to self-organize under controlled conditions giving rise nanostructures. Polymers, lipids, inorganic materials, peptides and proteins, and surfactants are examples of such biomaterials and the self-assembling property can be exploited to design nanovectors that are useful for drug delivery. The self-organization of nanostructures is an attractive approach to preparing nanovectors, avoiding complex and high-energy-consuming preparation methods, and, in some cases, facilitating drug loading procedures. Moreover, preparations based on these biocompatible and pharmaceutical grade biomaterials allow an easy transfer from the lab to the industrial scale. This book reports ten different works, and a review, aiming to cover multiple strategies and pharmaceutical applications in the field of self-organizing nanovectors for drug delivery.
    Keywords: R5-920 ; RM1-950 ; chitosan ; encapsulation ; gold nanoparticles ; pH/redox-responsive ; bolaform amphiphilic lipids ; irradiation cycles ; drug delivery ; caries prevention ; bolalipids ; nanocage ; natural extracts ; astaxanthin ; eukaryotic vaults ; nanoparticles ; amphiphilic random copolymers ; zoledronic acid ; triggered release ; nanohydrogels ; doxorubicin ; vapor nanobubbles ; curcumin ; gold reduction ; diffusion barrier ; liposomes ; hyaluronan ; laser treatment ; nanoparticle ; mixed polymeric micelles ; protein self-assembly ; squalene ; antimicrobial photodynamic therapy ; self-assembly ; hydrogel ; C-peptide ; polyelectrolyte complexes ; siRNA delivery ; drug delivery system ; biofilms ; pulmonary surfactant ; multidrug resistance ; drug delivery systems ; nano-assemblies ; photo-thermal therapy ; anticancer ; polypeptides ; graphene quantum dots ; nanovesicles ; aerogel ; resveratrol ; intracellular therapy ; Oral antimicrobials ; syringeable implant ; trehalose ; betulinic acid ; in situ gelling systems ; autophagy induction ; chorioallantoic membrane model ; controlled release ; diabetes ; oxidative stress ; localized heating effect ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Environmental health researchers have long used concepts like the neighborhood effect to assessing people’s exposure to environmental influences and the associated health impact. However, these are static notions that ignore people’s daily mobility at various spatial and temporal scales (e.g., daily travel, migratory movements, and movements over the life course) and the influence of neighborhood contexts outside their residential neighborhoods. Recent studies have started to incorporate human mobility, non-residential neighborhoods, and the temporality of exposures through collecting and using data from GPS, accelerometers, mobile phones, various types of sensors, and social media. Innovative approaches and methods have been developed. This Special Issue aims to showcase studies that use new approaches, methods, and data to examine the role of human mobility and non-residential contexts on human health behaviors and outcomes. It includes 21 articles that cover a wide range of topics, including individual exposure to air pollution, exposure and access to green spaces, spatial access to healthcare services, environmental influences on physical activity, food environmental and diet behavior, exposure to noise and its impact on mental health, and broader methodological issues such as the uncertain geographic context problem (UGCoP) and the neighborhood effect averaging problem (NEAP). This collection will be a valuable reference for scholars and students interested in recent advances in the concepts and methods in environmental health and health geography.
    Keywords: R5-920 ; the elderly ; regression analysis ; walking event ; green space ; missing data ; crop residue burning ; correlation analysis ; imputation ; physical environment ; crowdedness ; Guangzhou ; mobile phone data ; GPS trace ; noise pollution ; mental disorders ; Beijing ; urban leisure ; environmental exposure ; environmental context cube ; subway stations ; air pollution exposure ; long-distance walking ; car ownership ; multilevel model ; CHAS ; ecological momentary assessment ; cycling for transportation ; cognitive aging ; 3SFCA ; interannual and seasonal variations ; well-being experience ; personal projects ; spatial spread ; E2SFCA ; activity space ; catchment areas ; structural equation modeling ; transport modes ; greenspace exposure ; health ; train stations ; human mobility ; quantile regression ; the neighborhood effect averaging problem (NEAP) ; emissions estimation ; taxi GPS trajectories ; real-time traffic ; primary healthcare ; rail travel ; spatial accessibility ; commuting route ; GPS ; urban planning ; environmental health ; Brazil ; EMA ; geographical accessibility ; big data ; dynamic assessment ; obesity ; healthcare accessibility ; population demand ; the uncertain geographic context problem (UGCoP) ; geographic impedance ; collective leisure activity ; multimodal network ; GIS ; 2009 influenza A(H1N1) pandemic ; UGCoP ; environmental exposures ; spatial data ; the uncertain geographic context problem ; Singapore ; built environment ; adults ; time-weighted exposure ; geographic imputation ; Public Participatory GIS (PPGIS) ; access probability ; life-course perspectives ; China ; walking ; active travel ; foodscape exposure ; car use ; food environment ; fuel consumption ; ageing ; Healthcare services ; road traffic accidents ; space-time kernel density estimation ; multilevel Bayesian model ; environmental context exposure index ; spatial autocorrelation ; PM concentrations ; physical activity ; bike paths ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: For many years people assumed that children did not experience chronic pain. However, recent epidemiological studies show that chronic pain, defined as constant or recurrent pain lasting three months or longer, is common in childhood. Empirical studies have characterized chronic pain conditions including headaches, abdominal pain, chest pain, and musculoskeletal pains including fibromyalgia. These pain conditions are associated with school absence, emotional distress, disruption in family activities, and significantly reduced quality of life in both the affected child and their families. For some of these children, chronic pain persists from childhood into adulthood, causing substantial long-term personal and financial costs to the individual, society, and our health care systems. Despite the prevalence and serious consequences of pediatric chronic pain, it is still under-recognized and under-treated. Too often, chronic pain is treated as a symptom of something else, rather than as a separate condition requiring its own treatment. The goal of this Special Issue was to discuss recent advances in the understanding and treatment of pediatric chronic pain. The Special Issue Book contains 22 notable articles including original research, reviews, and commentaries. Together they provide an excellent overview of the field of chronic and recurrent pediatric pain as it stands in 2016–2017.
    Keywords: R5-920 ; Pediatrics ; Pain ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Obesity and eating disorders remain major public health concerns worldwide that often co-exist. While we are far from having definitive solutions, scientific insights into the prevention and management of obesity and eating disorders have developed significantly in recent years. This research has been stimulated by the continuous challenge of reducing the global burden of obesity and its commonly associated health complications, as well as the life-threatening characteristics of eating disorders. Looking towards better solutions for these pressing public health concerns, this book addresses recent scientific findings regarding the prevention and management of obesity and eating disorders. It reports on cognition and mental health in people with obesity, as well as on food addiction, co-morbidities of eating disorders, cultural aspects of eating, intermittent dietary energy restriction as a treatment for overweight or obesity, factors influencing the adherence to dietary treatments for overweight and obesity, philosophies underpinning dietary practices, treatment of eating disorders in men, cognitive remediation therapy for anorexia nervosa, and online or virtual interventions for weight management or bulimia nervosa. This book includes culturally diverse findings from research groups around the world (e.g. Australia, UK, Norway, Brazil), and is informative for healthcare professionals and researchers working in the fields of obesity and/or eating disorders.
    Keywords: R5-920 ; Therapy ; Treatment ; Diet therapy ; Eating disorders ; Mental health ; Health impact assessment ; Obesity/overweight ; Behavioural therapy ; bic Book Industry Communication::M Medicine
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    Publication Date: 2024-03-30
    Description: Advances in Peptide and Peptidomimetic Design Inspiring Basic Science and Drug Discovery is a book dedicated to Prof. Victor J. Hruby on the occasion of his 80th birthday. This book includes twenty contributions from authors representing diverse multidisciplinary fields of scientific expertise, and is focused on the extraordinary potential of peptides and peptidomimetics as a surging therapeutic modality and as tools for basic research and technology development.
    Keywords: R5-920 ; RM1-950 ; fusogenic ; small molecule ; cancer vaccine ; peptide-drug conjugate ; protein–protein interaction ; anticancer peptide ; tetrapeptides ; drug discovery ; ginkgo nuts ; prostaglandin F2? ; macrocyclic peptide ; melanocortins ; Toll-like receptor ; polo-box domain ; endosomolytic ; structure-activity ; free energy calculation ; peptide ; autophagy ; synthetic vaccine ; small antimicrobial peptides ; azapeptides ; classification ; multifunctional ligands ; cytoprotective ; polycationic -amino acids ; N-acetylated Pam2Cys ; Pam2Cys ; disulfide-rich scaffold ; d-amino acid scan ; VEGF165 ; antibiotics ; hyperdisulfide ; peptides ; random forest ; pseudosubstrate ; influenza hemagglutinin ; Ranalexin ; ?-ginkgotide ; LIR motif ; bioconjugation ; peptide agonist ; GnRH ; molecular rotor dye ; sensor chip ; helix-breaker ; Plk1 ; antimicrobial activity ; molecular dynamics ; machine learning ; melanocortin-4 receptor ; kinase inhibitor ; support vector machine ; D-amino acid ; drug screen ; receptor desensitization ; diabetes ; opioids ; selectivity ; IP20 ; aza-amino acids ; bis-benzamide scaffold ; G?S signaling ; chemical linker ; MC4R ; LHRH ; ?-hairpin ; androgen receptor ; adjuvant ; high throughput screening ; receptor internalization ; peptide design ; ?-helix mimetics ; adaptogenic ; obesity ; cardiovascular profile ; hypoxia ; programmed cell death ligand protein 1 ; PKA ; neuropilin-1 ; preterm labor ; ?-sheet ; PKI ; MC3R ; myometrium contractions ; amphiphilic ; structure–activity relationship ; peptidomimetics ; combinatorial chemistry ; sepsis ; coactivator PELP1 ; OBOC ; mixed-mode pharmacology ; configuration ; peptide permeability ; triazole ; stapled peptide ; cysteine-rich peptides ; GLP-1 ; RBC lysis ; mixed pharmacology ; therapeutic peptides ; opioid ; peptidomimetic ; prostate cancer ; alanine scan ; lipidation ; peptide therapeutics ; cancer ; pharmacophore
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The biennial Congress of the Italian Society of Oral Pathology and Medicine (SIPMO) is an International meeting dedicated to the growing diagnostic challenges in the oral pathology and medicine field. The III International and XV National edition will be a chance to discuss clinical conditions which are unusual, rare, or difficult to define. Many consolidated national and international research groups will be involved in the debate and discussion through special guest lecturers, academic dissertations, single clinical case presentations, posters, and degree thesis discussions. The SIPMO Congress took place from the 17th to the 19th of October 2019 in Bari (Italy), and the enclosed copy of Proceedings is a non-exhaustive collection of abstracts from the SIPMO 2019 contributions.
    Keywords: R5-920 ; RB1-214 ; modeling ; underwater vehicle ; gesture-based language ; text classification ; navigation and control ; motion constraints ; autonomy ; dynamics ; marine robotics ; unmanned surface vehicle ; field trials ; actuator constraints ; robust control ; fault detection and isolation ; remotely operated vehicle ; underwater manipulator ; intelligent control ; object obstacle avoidance ; submersible vehicles ; overcome strong sea current ; underwater robot ; maneuverability identification ; ROV ; Lyapunov stability ; VGI ; ocean research ; two-ray ; path loss ; obstacle avoidance ; parallel control ; approximated optimal control ; sliding mode control ; automation systems ; fault-tolerant control ; numerical calculation ; backstepping control ; deep learning ; unmanned underwater vehicle (UUV) ; underwater human–robot interaction ; aerial underwater vehicle ; thruster fault ; airmax ; position control ; cross-medium ; free space ; second path planning ; flow sensing ; underwater vehicle-manipulator system ; marine systems ; low-level control ; dynamic modelling ; kinematics ; vehicle dynamics ; WLAN ; viscous hydrodynamics ; fault accommodation ; RSSI ; nonlinear systems ; guidance ; simulation model ; artificial lateral system ; autonomous underwater vehicle ; typhoon disaster ; force control ; bic Book Industry Communication::M Medicine
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    Scandinavian University Press (Universitetsforlaget)
    Publication Date: 2023-12-21
    Description: This book introduces systems epidemiology, which is a new scientific discipline borne by novel technologies. These have opened up the potential for studies of temporal changes in the carcinogenic process and the response of the immune system, all measured as functional genomics: gene expression, microRNA and methylation. Systems epidemiology is an integrated approach based on epidemiological methods with biobanks designed for studies of the trajectories or curves of functional genomics moving from before diagnosis, at diagnosis and postdiagnostic. It demands new epidemiological designs, the globolomic one, new statistical methods for description and analyses of time changes and incorporating basic knowledge from reductionist experiments and clinical outcomes including molecular biomarkers of cancer tissue and normal tissues.
    Keywords: R5-920 ; epidemiology ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. NPs have also been implicated in the pathogenesis of several cardiovascular diseases (CVDs), including hypertension, atherosclerosis, heart failure, and stroke. A fine comprehension of the molecular mechanisms dependent from NPs and underlying the promotion of cardiovascular damage has contributed to improve our understanding of the molecular basis of all major CVDs. Finally, the opportunity to target NPs in order to develop new therapeutic tools for a better treatment of CVDs has been developed over the years. The current Special Issue of the Journal covers all major aspects of the molecular implications of NPs in physiology and pathology of the cardiovascular system, including NP-based therapeutic approaches.
    Keywords: R5-920 ; RC666-701 ; postmortem biochemistry ; medulla ; animal models ; remodeling ; BNP ; PCSK9 ; guanylyl cyclase/natriuretic peptide receptor-A ; cardiorenal syndrome ; forensic medicine ; preserved ejection fraction ; kidney ; renin-angiotensin-aldosterone system ; atrial fibrillation ; vasopressor ; congestive heart failure ; atrial natriuretic peptide ; gene-knockout ; obesity ; heart failure ; angiogenesis ; adipose tissue ; vascular ; LDL receptor ; metabolic syndrome ; linkage analysis ; cardiometabolic disease ; cardiomyocyte ; cardiac dysfunction ; cardiac hypertrophy ; insulin ; lipid metabolism ; cGMP ; Idiopathic Pulmonary Arterial Hypertension (IPAH) ; Natriuretic Peptide Clearance Receptor (NPR-C) signaling ; gene-duplication ; renin–angiotensin system ; natriuretic peptides ; angiotensin receptor–neprilysin inhibitor ; cardiac remodelling ; ARNi ; NT-proBNP ; inflammation ; pulmonary arterial hypertension ; vascular homeostasis ; endothelial cell ; Atrial Natriuretic peptide ; natriuretic peptide ; vasodilator ; stroke ; genetic variants ; arterial hypertension ; fibroblast ; MANP ; hypertension ; guanylyl cyclase receptor A ; bic Book Industry Communication::M Medicine
    Language: English
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  • 65
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Hydrogels are the foundation of regenerative medicine as a supportive matrix for cell immobilization and growth factor delivery. The fate of implanted cells is mediated by cell-matrix interaction at multiple scales and timed-release of growth factors to guide the differentiation and maturation of cells. Recently, there has been great interest in hydrogels with a hierarchical structure that mimics the complex interaction of cells with a microenvironment that can locally release growth factors to specific cells. Related topics in this Special Issue include hydrogels with a hierarchical structure; hybrid, degradable, and load-bearing hydrogels; hydrogels for cell encapsulation, micro-patterning, microfluidic devices, biofabrication, and high-throughput screening; and hydrogels that modulate the body’s immune response.
    Keywords: R5-920 ; Q1-390 ; cell encapsulation ; tissue engineering ; bioresponsive extracellular matrix mimetic ; hydrogel ; cell adhesion ; high throughput screening ; polyampholyte ; biphasic ; antifouling ; bioprinting ; bioactive ; bic Book Industry Communication::M Medicine
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  • 66
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Thousands of arthropod species, ranging from arachnids (spiders and scorpions) to hymenopterans (ants, bees, and wasps) and myriapods (centipedes), are venomous and use their venoms for both defense and predation. These venoms are invariably harmful to humans, and some may cause serious injuries, e.g., those from scorpions, spiders, and wasps. Arthropods’ venoms are also known as rich sources of biologically active compounds and have attracted the attention of toxin researchers for years. In this century, venom component analysis has progressed considerable due to the advances in analytical techniques, in particular, mass spectrometry and next-generation deep (DNA and RNA) sequencing. As such, proteomic and peptidomic analyses using LC–MS have enabled the full analysis of venom components, revealing a variety of novel peptide and protein toxins sequences and scaffolds, potentially useful as pharmacological research tools and for the development of highly selective peptide ligands and therapeutic leads, like chlorotoxin. Due to their specificity for numerous ion-channel subtypes, including voltage- and ligand-gated ion channels, arthropod neurotoxins have been investigated to dissect and treat neurodegenerative diseases and control epileptic syndromes. This Special Issue collects information on such progress, encouraging contributions on the chemical and biological characterization of venom components, not only peptides and proteins, but also small molecules, their mechanisms of action, and the development of venom-derived peptide leads.
    Keywords: R5-920 ; RA1190-1270 ; n/a ; spider toxin ; hybrid immunogen ; channel-like pore-forming activity ; venom peptides ; chemotherapy ; piperidine heterocyclic amines ; computational docking ; insect immune system ; venom ; toxoplasmosis ; wasps ; ion channel structure ; mechanical allodynia ; Dinoponera quadriceps ; natural antibiotics ; bees ; acid-gated currents ; nematicide ; novel therapeutics ; toxins ; protons ; Hymenoptera venom ; ants ; chronic pain ; heart contractility ; transcriptome ; drug targets ; skin ; peptides ; LTQ Orbitrap Hybrid Mass Spectrometer ; cantharidin ; Centruroides limpidus Karch ; pilosulin-like peptide ; mechanism ; scorpion ; stent ; homology modelling ; amphipathic ?-helix structure ; Berberomeloe majalis ; mass spectrometric analysis ; phospholipases D ; Nav1.7 ; biotools ; metalloproteases ; myrmecology ; Tenebrio molitor ; antifeedant ; ixodicide ; virtual screening ; Loxosceles ; acid-sensing ion channels ; small hive beetle ; knottins ; Nav channel activity ; envenomation ; pharmacology ; Staphylococcus aureus ; spider venom ; scorpion venom ; insecticidal peptide ; Formicidae ; AMP ; de novo sequencing ; tertiapin ; leishmaniasis ; brown spider ; proteome ; keratitis ; Acinetobacter baumannii ; neuropathic pain ; bee venom ; bioinformatics ; ICK peptide ; human African trypanosomiasis ; automated patch-clamp ; Hymenoptera ; antimicrobial peptide ; LyeTxI-b ; linear cationic ?-helical peptide ; melittin ; Chagas disease ; mass spectrometry analysis ; neutralizing antibodies ; apoptosis ; protein–peptide interactions ; malaria ; pH regulation ; voltage-gated sodium channel ; venom toxicity ; insect neurotoxin ; solitary wasp ; oxaliplatin ; arthropod ; mastoparan ; cold allodynia ; pain target ; cutaneous disease ; pain ; NaV ; proteomics ; industrial biotechnology ; ant ; directed disulfide bond formation ; antivenoms ; blister beetle ; venom allergens ; ICK-like toxins ; Loxosceles spp. ; alternative treatment ; recombinant toxins ; FMRF-amide ; bic Book Industry Communication::M Medicine
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  • 67
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Cyanobacteria are a group of ubiquitous photosynthetic prokaryotes. Their occurrence has been increasing worldwide, due to anthropogenic activities and climate change. Several cyanobacterial species are able to synthesize a high number of bioactive molecules, among them, cyanotoxins (microcystins, cylindrospermopsin, nodularin, etc.), which are considered a health concern. For risk assessment of cyanotoxins, more scientific knowledge is required to perform adequate hazard characterization, exposure evaluation and, finally, risk characterization of these toxins. This Special Issue “Cyanobacteria and Cyanotoxins: New Advances and Future Challenges” presents new research or review articles related to different aspects of cyanobacteria and cyanotoxins, and contributes to providing new toxicological data and methods for a more realistic risk assessment.
    Keywords: R5-920 ; RA1190-1270 ; method validation ; sirtuin 1 (SIRT1) ; arctic ; Cylindrospermopsin ; Microcystin-LR ; 16S rRNA gene ; astaxanthin ; secondary metabolites ; shotgun metagenomic sequencing ; time-resolved fluoroimmunoassay ; Histopathological evaluation ; cyanobacterial thresholds ; akinetes ; nutrient enrichment ; benthic mats ; cylindrospermopsin ; drinking water treatment plant ; blue-green algae supplements ; lettuce ; genotoxicity ; exposure ; bacterial community ; PCR ; microcystin-LR ; marine natural compounds ; ELISA ; [d-Leu1]Microcystin-LR ; Paracentrotus lividus ; tadpoles ; apoptosis ; 16S rRNA gene sequencing ; PSP toxins ; marine cyanobacteria ; hemolytic essay ; energy budget ; bioassays ; anatoxin-a ; Lithobates catesbeianus ; mixture ; reproductive toxicity ; cyanobacteria ; taste-and-odor compounds ; Procambarus clarkii ; drinking water ; saxitoxin ; resveratrol ; harmful algal blooms ; cytotoxicity ; phylogenetic analyses ; Yangtze estuary ; microcystin ; mutagenicity ; detection ; Artemia salina ; water source ; cyanotoxins ; microcystins ; in vitro ; marine sponges ; microcystin-LR (MC-LR) ; UPLC-MS/MS ; reservoir ; microbial metabolisms ; Aphanizomenon flos-aquae ; monoclonal antibody ; oxidative stress ; Nostocales ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2024-03-30
    Description: The Neuroproteomics Special Issue overviews the unique challenges that must be addressed to carry out meaningful MS/proteomics analyses on neural tissues and the technologies that are available to meet these challenges. The articles on Alzheimer’s disease, addiction, and schizophrenia illustrate how MS/proteomics technologies can be used to improve our ability to diagnose and understand the molecular basis for neurological diseases. Several articles will be of interest to investigators beyond the field of neurological disorders. The review on the discovery of biofluid biomarkers of neurodegenerative dementias will be of interest to investigators searching for other disease biomarkers. Similarly, the review on the role of neuroproteomics in elucidating mechanisms of drug addiction provides an overview of the utility of MS/proteomics approaches for addressing critical questions in addiction neuroscience that should be applicable to investigators involved in virtually any area of biomedical research. Likewise, the article on developing targeted MS approaches for quantifying postsynaptic density proteins will be useful for any investigator who wishes to design targeted assays for virtually any protein. Finally, the peroxidase-mediated proximity labeling technology, described in the article on mapping the proteome of the synaptic cleft, will be of interest to investigators interested in mapping other spatially restricted proteomes.
    Keywords: R5-920 ; RC346-429 ; n/a ; analgesia ; quantitative phosphoproteomics ; neurodegeneration ; neuron ; neuronal circuits ; mating ; sex-specific differences ; AMPA receptor complex ; parallel reaction monitoring ; splicing ; phosphorylation ; peptidylglycine ?-amidating monooxygenase ; pherophorin ; Alzheimer’s disease ; neuroscience ; yohimbine ; synapses ; adolescence ; conformational antibody ; opioid receptors ; protein interaction networks ; Alzheimer’s Disease ; transmembrane AMPA receptor regulatory protein ; neuroproteome ; ethanol ; U1 snRNP ; mass spectroscopy ; morphine ; protein phosphatase-1 ; neuroproteomics ; axons ; reinstatement ; DIA ; voltage gated channels ; prohormone convertase ; postsynaptic density ; neuroimmune ; dendrites ; carboxypeptidase ; GPCR signaling ; CaMKII ; FGF14 ; SynCAM ; nicotinic receptor ; synaptic plasticity ; plasma ; serum ; corticosterone ; dopamine ; Receptor-type tyrosine-protein phosphatase zeta ; Ptprz1 ; PRM ; cell type ; schizophrenia ; laser capture microdissection ; synapse specificity ; LC-MS/MS ; mouse ; drug abuse ; synaptic cleft ; striatum ; Cadm ; cytokine ; spinophilin ; PSD ; trans-synaptic adhesion ; nicotine ; proximity labeling ; biomarkers ; addiction ; PKA ; synapse ; proteome ; signal peptide ; ventral tegmental area ; protein aggregation ; cerebrospinal fluid ; bioinformatics ; progressive ratio ; interactome ; subtilisin ; affinity chromatography ; basal ganglia ; cocaine ; targeted proteomics ; postsynaptic ; mass spectrometry ; connectome ; quantitative mass spectrometry ; biotinylation ; proteomics ; amphetamine ; autism ; data-independent acquisition ; excitatory/inhibitory tone ; neuropeptidomics ; matrix metalloproteinase ; cilia ; R-PTP-zeta ; cognitive impairment
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  • 69
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Mitochondrial disease constitutes a complex and heterogeneous group of disorders resulting from a defect in mitochondrial respiratory chain (MRC) enzyme activity. In view of the dual regulation of the MRC, exercised by both the mitochondrial and nuclear genome, mutations in either mitochondrial or nuclear DNA can result in a MRC deficiency. Whilst a single organ can be affected, MRC disorders often result in a multi-organ system presentation with prominent neurological and myopathic features. The diagnosis of MRC disorders can be complex, and requires a coordinated interplay of a number of disciplines. However, biochemical determination of metabolites in blood, cerebral spinal fluid (CSF) and/or urine are generally considered to be first-line investigations for the diagnosis of these disorders, although they lack sensitivity and specificity. Furthermore, there is a lack of consensus on the overall utility of monitoring other biochemical parameters, which may be of diagnostic value. For example, although oxidative stress may contribute to the pathogenesis of mitochondrial disorders, few centers monitor this as part of their diagnostic repertoire. Therefore, the purpose of this Special Issue was to highlight potential biomarkers of mitochondrial disease and to discuss the appropriateness of biochemical markers to monitor disease progression and therapeutic intervention.
    Keywords: R5-920 ; RA1-1270 ; RM1-950 ; biomarks ; diagnosis ; mitochondrial respiratory chain (MRC) ; mitochondrial disorders ; biochemical parameters/markers ; oxidative stress ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: ca. 200 words; this text will present the book in all promotional forms (e.g. flyers). Please describe the book in straightforward and consumer-friendly terms. [One of the main aspirations of the European Union (EU) is the development of a pan-European health system with unhindered access to quality care, in all member states. The PHAR-QA “Quality Assurance in European Pharmacy Education and Training” project explored the realities surrounding this idea in the area of pharmacy. This book assembles a series of papers, already published in the journal “Pharmacy”, that describe the project: its origins, design, implementation, results, interpretation, and perspectives.]
    Keywords: R5-920 ; RM1-950 ; competence ; education ; pharmacy ; bic Book Industry Communication::M Medicine
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  • 71
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This special issue entitled “Soft and hard tissue regeneration” will cover both periodontal and implant therapies. Regenerative periodontal treatment goal is to restore functional periodontal support offering a valuable treatment alternative even for teeth with large periodontal destruction, which may be successfully treated and maintained in health for long periods. In most cases where teeth are extracted for periodontal reasons, implant therapy will demand large bone augmentation procedures. Lack of sufficient bone volume may prevent placement of dental implants. In extreme cases, large bone reconstruction is indispensable before implant placement can be performed. Although, most bone grafts are only able to fill and maintain a space, where bone regeneration can occur (“osseoconductive”), the ideal bone graft will also promote osseous regeneration (“osseoinductive”). Several bone augmentation procedures have been described, each, presenting advantages and shortcomings. Success of bone augmentation procedures depends on the presence of bone forming cells, primary wound closure over the augmented area, space creation and maintenance where bone can grow and proper angiogenesis of the grafted area. Factors that influence the choice of the surgical technique are the estimated duration of surgical procedure, its complexity, cost, total estimated length of procedure until the final rehabilitations may be installed and the surgeons’ experience. This special issue will have a definite clinical orientation, and be entirely dedicated to soft and hard tissue regenerative treatment alternatives, both in periodontal and implant therapy, discussing their rationale, indications and clinical procedures. Internationally renowned leading researchers and clinicians will contribute with articles in their field of expertize.
    Keywords: R5-920 ; RK1-715 ; dog study ; root coverage ; n/a ; bone grafts ; aggregation ; enamel matrix proteins derivative ; bone substitutes ; periodontal surgery ; animal study ; ?-tricalcium phosphate ; bone regeneration ; combination therapy ; videoscope ; socket preservation ; guided tissue regeneration (GTR) ; biologics ; deproteinized bovine bone ; minimally invasive ; platelet-rich plasma ; platelets ; Alveolar ridge preservation ; periodontal regeneration ; Smart Dentin Grinder ; quality assurance ; tooth particles ; enamel matrix derivatives (Emdogain®) ; autogenous particulate tooth graft ; aggressive periodontitis ; spectrophotometer ; soft tissue management ; connective tissue graft ; bic Book Industry Communication::M Medicine
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  • 72
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Monoclonal antibodies are established in clinical practice for the treatment of cancer, and autoimmune and infectious diseases. The first generation of antibodies has been dominated by classical IgG antibodies, however, in the last decade, the field has advanced, and, nowadays, a large proportion of antibodies in development have been engineered. This Special Issue on "Monoclonal Antibodies" includes original manuscripts and reviews covering various aspects related to the discovery, analytical characterization, manufacturing and development of therapeutic and engineered antibodies.
    Keywords: R5-920 ; RC581-607 ; antibody drug conjugates ; bispecific antibodies ; engineered antibodies ; antibody-like scaffolds ; monoclonal antibodies ; bic Book Industry Communication::M Medicine
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  • 73
    Publication Date: 2023-12-21
    Description: Tissue fibrosis may occur for unknown causes or be the consequence of many pathological conditions including chronic inflammatory or infectious diseases, autoimmune disorders, graft rejection, or malignancy. On the other hand, malignant tumors have been identified in fibrotic tissues decades ago, and now accumulating evidence suggests that fibrotic lesions enhance the risk of cancer in several organs such as liver, lungs, and breast. Disruption of an organ parenchymal cells and of its normal structural scaffold during tissue fibrogenesis appears to induce loss of cell polarity, promoting uncontrolled cell proliferation that may eventually lead to cancer development. Many cellular and molecular abnormalities including aberrant expression of microRNAs, genetic and epigenetic alterations, evasion or delayed apoptosis, unregulated intracellular signal pathways, and dysregulation or defective intercellular communications have been proposed to explain this link between fibrogenesis and carcinogenesis. However, the precise mechanisms of this fibrosis-to-cancer transition remain unclear. This book presents a collection of reviews and original articles summarizing recent advances in understanding the molecular mechanisms of cancer development in fibrotic organs.
    Keywords: R5-920 ; RC31-1245 ; bleomycin ; n/a ; regeneration ; antitumor efficacy ; lung cancer ; SOX2 ; leiomyosarcoma ; lung cancer (LC) ; nanoparticles ; cytokines ; hepatocellular carcinoma ; metabolic reprogramming ; hepatic stellate cells ; angiogenesis ; transforming growth factor-? ; anaplastic lymphoma kinase ; idiopathic pulmonary fibrosis ; growth factor ; pathogenesis ; cancer-associated fibroblasts ; fibrosis ; lipopolysaccharide ; DHA ; lncRNA ; SREBP-1 ; YAP ; protein S ; non-small cell lung cancer (NSCLC) ; omega-3 fatty acid ; inflammation ; metastasis ; clinical symptoms ; miRNA ; smooth muscle tumor of uncertain malignant potential ; Wnt ; interstitial fluid pressure ; heterogeneity ; hepatocytes ; myometrium ; tumor necrosis factor ? ; tumor ; tumor microenvironment ; extracellular matrix ; TAZ ; carcinogenesis ; cystic formation ; pulmonary fibrosis ; HBV ; cytokine ; genetic instability ; diagnosis ; EMT ; crizotinib ; Hippo pathway ; GPR120 ; marker ; HCV ; non-alcoholic steatohepatitis ; pathology ; common pathways ; apoptosis ; type I collagen ; GPR40 ; acute lung injury ; uterine fibroid ; renal injury ; pathophysiology ; reactive oxygen species ; immunohistochemistry ; SMAD ; butylidenephthalide ; leiomyoma ; cirrhosis ; Erk1/2 ; targeted therapy ; TGF-? ; mechanotransduction ; therapy ; breast cancer ; hepatocellular carcinoma (HCC) ; hepatic stellate cells (HSCs) ; idiopathic pulmonary fibrosis (IPF) ; cancer-associated fibroblasts (CAFs) ; cancer ; signal pathway ; tumor stiffness ; bic Book Industry Communication::M Medicine
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  • 74
    Publication Date: 2023-12-21
    Description: Some 20% of the population is required to work outside the regular 9:00 a.m.–5:00 p.m. working day, and this number is likely to increase as economic demands push work hours into the night for many companies. These irregular schedules mean workers often have to sleep during the day and be awake at night. This causes a misalignment between normal day-light entrained internal physiological processes, such as metabolism and digestion, and the external environment. As a direct consequence, night workers have poorer health than day workers, even after controlling for lifestyle and socioeconomic status. The purpose of this Special Issue is to highlight the interrelationships between timing of food intake and diet quality with sleep and work patterns in humans with an emphasis on randomized controlled trials or meta-analyses of data from published studies.
    Keywords: R5-920 ; Shiftwork and dietary patterns ; sleep and work ; Sleep and dietary factors ; Diet quality ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Marine natural products containing a heterocyclic moiety in their structure are present in a wide variety of sponges, corals, algae, and fungi. Many of them show important biological activities such as cytotoxic properties against several cancer cell lines. Their challenging chemical structures have attracted the attention of many researchers who have developed various synthetic approaches. This Special Issue presents some examples of new synthetic or biosynthetic methodologies to access this type of marine natural drug.
    Keywords: R5-920 ; RM1-950 ; antarctic-derived fungus ; marine drugs analogues ; antitumor ; pallescensone ; Haematococcus pluvialis ; toluquinol ; antiproliferative activity ; astaxanthin ; thymoquinone ; alotamide ; microalgae ; tetrahydropyrans ; isomicrocionin-3 ; hybrid polyketides ; anticonvulsant ; peptide/polyketide molecules ; functional-analogues ; Synechococcus sp. PCC 7942 ; natural compound analogues ; LLC-PK1 cells ; structural modification ; relative structural determination ; benzo[d]thiazol ; Cladosporium sphaerospermum ; hybrid PKS-NRPS ; anticandidal activity ; Octopus minor ; dihydropallescensin 2 ; Candida albicans ; Iso-Seq ; biological activity ; Octominin ; pallescensin 2 ; pallescensin 1 ; stereoselective ; synthetic analogues ; psammaplin A ; cyclogeranylsulfonylbenzene isomers ; synthesis ; smenamides ; MM cell line ; ?-ketoacyl ACP Synthase ; antidepressant ; marine natural products ; marine hydroquinone ; tetramic acid ; asymmetric synthesis ; acid mediated cyclization ; stereoselective synthesis ; GGPPS ; furanosesquiterpenes ; marine natural product ; short chain fatty acids ; antimicrobial peptides ; lipase-mediated resolution ; bic Book Industry Communication::M Medicine
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  • 76
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Over the last few years, polyphenol has received a great deal of attention due to their potential beneficial effects on human health. Widely contained in foods commonly consumed in all populations worldwide, polyphenols represent an attractive explanation of the beneficial effects, not only of fruits and vegetables, characteristic components of healthy dietary patterns, but also of other plant-derived foods, such as tea, coffee, and cocoa, which only recently have been exploited as being beneficial for humans. In addition to the numerous biological properties, polyphenols have been indicated as being responsible for a decreased risk of metabolic disorders, cardiovascular disease, and certain cancers. The book addresses original research and reviews of literature concerning polyphenol-rich foods and human health.
    Keywords: R5-920 ; polyphenols ; antioxidants ; inflammation ; prevention of non-communicable diseases ; flavonoids ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Plants have served mankind as an important source of foods and medicines. While we all consume plants and their products for nutritional support, a majority of the world population also rely on botanical remedies to meet their health needs, either as their own “traditional medicine” or as “complementary and alternative medicine”. From a pharmaceutical point of view, many compounds obtained from plant sources have long been known to possess bio/pharmacological activities, and historically, plants have yielded many important drugs for human use, from morphine discovered in the early nineteenth century to the more recent paclitaxel and artemisinin. Today, we are witnessing a global resurgence in interest and use of plant-based therapies and botanical products, and natural products remain an important and viable source of lead compounds in many drug discovery programs.This Special Issue on “Plant Natural Products for Human Health” compiles a series of scientific reports to demonstrate the medicinal potentials of plant natural products. It covers a range of disease targets, such as diabetes, inflammation, cancer, neurological disease, cardiovascular disease, liver damage, bacterial, and fungus infection and malarial. These papers provide important insights into the current state of research on drug discovery and new techniques. It is hoped that this Special Issue will serve as a timely reference for researchers and scholars who are interested in the discovery of potentially useful molecules from plant sources for health-related applications.
    Keywords: R5-920 ; RM1-950 ; PhGs ; bitter orange ; immunomodulator ; A549 cells ; bergapten ; triptolide ; BMP/Smad ; phytochemicals ; antioxidant enzymes ; kumquat ; MTT assay ; HepaRG cells ; human health ; nanoparticles ; dendritic cells ; drug discovery ; biofilm ; catechin ; antitubercular activity ; Panax notoginseng saponins ; animals ; mouse-hair growth ; A? ; curcumin ; WNT/?-catenin ; copaiba ; AD ; Plasmodium parasites ; traditional medicine ; procyanidin A2 ; PET inhibition ; rheumatoid arthritis ; cannabinoid type 1 receptor ; iridoids ; inflammatory bowel disease ; acute liver injury ; human-hair-follicle dermal papilla cells ; Neuroprotective ; dihydromyricetin ; AMPK ; thromboembolism ; ginseng ; drug design and development ; endoplasmic reticulum stress ; mitogen-activated protein kinase ; Nrf2 ; prenylated flavonoids ; inflammation ; preclinical studies ; plants ; dietary supplements ; Glycyrrhiza uralensis ; aspirin ; Tripterygium wilfordii ; P. eryngii ; reperfusion ; ethnopharmacology ; glucans ; innovation ; hpatoprotection ; hinokitiol ; phytocannabinoid ; antistaphylococcal activity ; Shh/Gli ; green tea ; sesquiterpenoids ; adjuvant-induced arthritis ; yuzu ; hepatotoxicity ; p53/Bax ; Keap1 ; nuclear factor-kappaB ; oxidative stress ; pharmacokinetic study ; cinnamamides ; toxicity ; APAP ; Astragali Radix ; computational softwares ; plant natural product ; onion ; anti-malaria activity ; lipogenesis ; bleeding time ; diterpenoids ; Penthorum chinense Pursh ; myocardial hypertrophy ; automation ; adjuvant ; grapefruit ; melanoma cell ; essential oil ; sweet orange ; Amadori rearrangement compounds ; heme oxygenase ; global health ; calorie restriction ; bergamot ; liposomes ; EGCG ; celastrol ; herb–drug interactions ; cannabigerol ; anti-inflammation ; OH· free radical ; molecular targets ; gluconeogenesis ; microbiome ; SIRT1 ; fucoidan ; heart ; PC12 cells ; acetaminophen ; omics ; time-kill assay ; arthritis ; lychee seed ; bioinformatics ; structure–activity relationship ; precision medicine ; orange petitgrain ; immune modulation ; antiproliferation ; flavonoids ; scoulerine ; oleoresin ; triterpenic acids ; Cannabis sativa ; NAFLD ; biological activity ; differentiation ; oxygen consumption rate ; mitochondrial bioenergetics ; neroli ; apoptosis ; targeted delivery ; platelet activation ; protein kinase ; heat-process ; hepatic steatosis ; hyperglycemia ; natural products ; lemon ; genistein ; neuroinflammation ; astragaloside IV ; cytoxicity ; flavonoid ; paracetamol ; medicinal plants ; insulin resistance ; resveratrol ; mandarin ; garlic ; TGF-? ; morin hydrate ; sirtuin 3 ; MMPs ; gomisin N ; lime ; Ziziphus jujuba ; antifungal activity ; ischemia ; migration ; caspases ; small molecules ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Ribosome inactivating proteins (RIPs) form a vast family of hundreds of toxins from plants, fungi, algae and bacteria. RIP activities have also been detected in animal tissues. They target a single adenine of a ribosomal RNA, thereby blocking protein synthesis and leading intoxicated cells to apoptosis. The role of plant RIPs may be related to plant defense against predators and viruses, plant senescence or bacterial pathogenesis. Most RIPs are no threat to human or animal health. However, several bacterial RIPs are major virulence factors involved in severe epidemic diseases such as dysentery or the hemolytic uremic syndrome that may occur in patients suffering from Shiga toxin-producing entero-hemorrhagic Escherichia coli infection. Several plant RIPs such as ricin toxin, abrin or sarcin have been, or may be involved in accidental or criminal poisonings, political intimidation or bio-suicides. Health crisis, biosafety and biosecurity issues became a major concern and many efforts are made to develop treatments. Finally, RIPs can be engineered into immunotoxins to destroy cancer cells or cells chronically infected by viruses. This book presents the most recent data on all aspects of RIPs including function, diversity and evolution, mechanism, pathophysiology, medical countermeasures and engineering into anticancer drugs.
    Keywords: R5-920 ; RM1-950 ; RA1190-1270 ; toxin ; Shiga toxin ; ricin ; Ribosome inactivating protein ; bic Book Industry Communication::M Medicine
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The aim of this collection of papers is to provide the reader with a cogent understanding of the role of evidence in the development of social or community-based interventions to promote inclusion oral-health and reduce oral health, health, and psychosocial inequities. In addition, this material will include various methods used for their implementation and evaluation. At the outset, the reader will be offered a working definition of inclusion oral-health, which will be modelled on the work of Luchenski et al. [1]. The interventions described are theoretically underpinned by a pluralistic definition of evidence-based practice [2] and the radical discourse of health promotion as postulated by Laverack and Labonte [3] and others [4,5]. This Special Issue will consist of eight papers, including an introduction. The first three papers will examine the various sources of evidence used to transform top-down into bottom-up community-based interventions for people experiencing homelessness; people in custody and for families residing in areas of high social deprivation. The final four papers will report on the implementation and evaluation of social or community-based interventions. This collection of research papers will highlight the importance of focusing on prevention and the adoption of a common risk factor agenda to tackle oral health, health and psychosocial inequities felt by those most excluded in our societies.
    Keywords: R5-920 ; RK1-715 ; dental health services ; oral health care ; parental knowledge ; obvious decay ; young people ; prison ; critical consciousness ; oral health education ; oral health ; attitudes and behaviors ; accessible dental services ; baby oral health ; social and community-based interventions ; undocumented migrants ; homeless persons ; undocumented migrant ; social exclusion ; community health workers ; oral health-related quality of life ; prisons ; inclusion oral health ; homelessness ; delivery of health care ; undocumented immigrants ; pedagogical approaches ; bic Book Industry Communication::M Medicine
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  • 80
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Polyphenols are commonly found in fruits and vegetables, and have been suggested to have protective effects against chronic diseases, such as cancers. They are a diverse group of molecules, many of which possess antioxidant, anti-inflammatory, epigenetic, drug sensitization, and/or modulation of xenobiotic metabolizing enzyme properties. However, there is mixed evidence regarding their protective effects with respect to various cancers. Some of this controversy may be due to the combination of polyphenols administered, synergistic effects of accompanying compounds, bio-accessibility, bioavailability, effect of gut microbiota, and the type of cancer investigated. The purpose of this Special Issue is to present the recent evidence for the effect of polyphenol intake on cancer, as well as mechanisms of action. This Special Issue, entitled "Polyphenols for Cancer Treatment or Prevention", welcomes manuscript submissions of original research, meta-analyses, or reviews of the scientific literature. Authors should focus their manuscripts on polyphenol bioactives or dietary patterns naturally rich in polyphenols that have been identified and used for the prevention and or treatment of cancer.
    Keywords: R5-920 ; cancer prevention ; synergistic effects ; Polyphenols ; bic Book Industry Communication::M Medicine
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  • 81
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The focus on dopamine-sensitive motor symptoms, in association with the improvement of motor complications in the heterogeneous disease entity Parkinson's disease, has led to a certain standstill in research. This Special Issue provides new concepts and new ideas on the pathogenesis, genetics, and clinical maintenance of Parkinson's disease and related disorders. Not only new experimental findings, but also clinical outcomes, case series, and research on alternative, non-pharmacological therapies are included. The objective is to bridge the currently increasing gap between experimental and clinical research on Parkinson's disease and related disorders.
    Keywords: R5-920 ; RC321-571 ; microRNAs ; disease-modifying effects ; SH-SY5Y ; inpatient treatment ; sphingolipids ; neurodegeneration ; magnetic resonance spectroscopy ; MO3.13 ; schizophrenia ; epigenetics ; long-chain acylcarnitine ; molecular mimicry ; curli ; multimodal complex treatment ; chlorogenic acid ; glycerophospholipids ; caffeic acid ; lipoproteins ; myenteric plexus ; neurometabolites ; HOG ; immature oligodendrocyte ; autophagy ; oligodendrocyte ; hypochlorite ; alpha-synuclein ; microbiome ; glucocerebrosidase ; Lewy Body Dementia ; brain iron ; mesenchymal stem cells ; fatty acid ?-oxidation ; GABA ; enteric glial cell ; gut-brain axis ; microbiota ; REM sleep behavior disorders ; redox cycling ; magnetic resonance imaging ; differentiation ; ?-synuclein-mediated pathology ; Parkinson disease ; Gaucher’s disease ; metallothionein ; [123I]FP-CIT-SPECT ; dopaminergic neuron ; mature oligodendrocyte ; glycerolipids ; spectroscopy ; neuroinflammation ; exosomes ; immunotherapy ; DNA methylation ; sterol lipids ; nigral cells ; cell line ; cysteinyl-dopamine ; myelin ; parkinsonisms ; multiple sclerosis ; rotenone ; brain ; fatty acyls ; Krabbe’s disease ; neuroprotection ; DAT ; motor dysfunction ; secretome ; multiprofessional therapy ; Parkinson’s disease ; oxidative stress ; alpha-Synuclein ; bic Book Industry Communication::M Medicine
    Language: English
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  • 82
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The field of reprogramming somatic cells into induced pluripotent stem cells (iPSC) has moved very quickly, from bench to bedside in just eight years since its first discovery. The best example of this is the RIKEN clinical trial this year in Japan, which will use iPSC derived retinal pigmented epithelial (RPE) cells to treat macular degeneration (MD). This is the first human disease to be tested for regeneration and repair by iPSC-derived cells and others will follow in the near future. Currently, there is an intense worldwide research effort to bring stem cell technology to the clinic for application to treat human diseases and pathologies. Human tissue diseases (including those of the lung, heart, brain, spinal cord, and muscles) drive organ bioengineering to the forefront of technology concerning cell replacement therapy. Given the critical mass of research and translational work being performed, iPSCs may very well be the cell type of choice for regenerative medicine in the future. Also, basic science questions, such as efficient differentiation protocols to the correct cell type for regenerating human tissues, the immune response of iPSC replacement therapy and genetic stability of iPSC-derived cells, are currently being investigated for future clinical applications.
    Keywords: R5-920 ; clinical application ; differentiation ; adult stem cell ; human disease ; immune response ; induced pluripotent stem cells ; genetic cell stability ; bic Book Industry Communication::M Medicine
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  • 83
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Marine proteins and peptides have great potential application in developing pharmaceuticals, nutraceuticals, and cosmeceuticals. Proteins and peptides from marine sources are considered to be safe and inexpensive. Protein- and peptide-based drugs have been increasing in recent days to cure various diseases by serving multiple roles, such as antioxidants, anticancer drugs, antimicrobials, and anticoagulants. There are different marine sources (macroalgae, fish, shellfish, and bivalves), which possibly contain specific protein and peptides.
    Keywords: R5-920 ; anticoagulant proteins and peptides ; cardio protective proteins and peptides ; fish collagen ; antifreeze proteins and peptides ; antihypertensive proteins ; anticancer proteins and peptides ; antimicrobial protein and peptides ; antitumor proteins and peptides ; antioxidant proteins and peptides ; macro algae protein ; isolation process ; fish gelatin ; digestive enzymes ; bic Book Industry Communication::M Medicine
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  • 84
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The role of major dietary omega-3 fatty acids (Ω-3; α-linolenic acid, eicosapentaenoic acid and docosahexaenoic acid) in human health has generated enormous scientific interest and many controversies in recent years. Due to a growing number of studies with conflicting or even negative clinical results, the former “hype” of Ω-3 thought to be beneficial in many aspects of human health regardless of the physiological and clinical preconditions is now being critically re-evaluated, especially with respect to the potential role of Ω-3 fatty acid supplementation in preventing a variety of diseases and clinical conditions. This critical view reflects the complex interaction of Ω-3 with cell membranes and their integrated proteins mediating signal transduction, transport systems, and other processes. Moreover, Ω-3 are precursors of bioactive metabolites, such as eicosanoids, lipoxins, resolvins, protectins, maresins, and nitrolipids that influence several physiological and pathophysiological processes and their full spectrum of effects are only beginning to be defined. Finally, physiological and pathophysiological conditions as well as concomitant pharmacological treatments may influence the specific and non-specific actions of Ω-3 supplementation. This Special Issue of the Journal of Clinical Medicine will emphasize the role and biological interactions of Ω-3 with regard to cancer, psychiatric disorders, metabolic disorders and nutrition and will also reflect on some basic molecular and cellular mechanisms.
    Keywords: R5-920 ; Obesity ; nutrition ; Alzheimer’s disease ; inflammation ; Schizophrenia ; Depression ; Dyslipidaemia ; cancer ; Diabetes ; rheumatoid arthritis ; bic Book Industry Communication::M Medicine
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  • 85
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The overall goal of this book is to give the reader a state-of-the-art synopsis of the pharmacist services domain. To accomplish this goal, the authors have addressed the social, psychosocial, political, legal, historic, clinical, and economic factors that are associated with pharmacist services. In this book, you will gain cutting-edge insights from learning about the research of experts throughout the world. The findings have relevance for enhancing pharmacist professionalism, pharmacist practice, and the progression of pharmacist services in the future.
    Keywords: R5-920 ; RS1-441 ; n/a ; medication experience ; medication safety ; collaborative practice ; age disparities ; Comprehensive Medication Management ; pharmacist ; pharmaceutical care ; readmissions ; healthy people 2020 ; multiple chronic conditions ; comparative case study ; billing ; interprofessional care ; clinical pharmacy ; safety ; community pharmacy ; qualitative research ; 21st century history ; medication management ; innovation science ; clinical results ; healthcare access ; documentation ; cost avoidance ; code of ethics ; misuse ; intention ; experiential learning ; opioid use disorder ; pharmacist workforce ; adverse drug events ; cue orientation ; pharmacy intern ; continuity of patient care ; decision-making ; community-based pharmacist practitioners ; service process ; quality assurance ; vaccination ; medication-related problems ; medication therapy management ; chronic kidney disease ; services marketing ; pharmacist roles ; health workers ; disposal ; federally qualified health center ; pharmacy services ; student pharmacist ; pharmacy communication ; interrupted time series analysis ; interprofessional practice and education ; 20th century history ; pharmacist services ; transitions in care ; retail clinics ; pharmacy clinical services ; counseling ; brown bag ; chronic diseases ; observation ; medication therapy problems ; ambulatory care ; mobile health units ; human papilloma virus ; community-based pharmacy ; medication reconciliation ; pharmacy learners ; collaboration ; care plan ; primary care ; interprofessional training ; travel ; theory of planned behavior. ; information sharing ; pharmacy practice ; health care policy ; medication adherence ; ethics ; pharmaceutical intervention ; medication synchronization ; counselling ; comprehensive medication review ; medication use burden ; dispensing ; pharmacy staff ; communication ; mental illness ; pharmacy benefit manager (PBM) ; focus group interviews ; South Asian ; pharmaceutical regulation ; wellness programs ; serviced marketing ; emergency unit ; immunization ; pharmacy ; quality measurement/benchmarking ; advanced practice pharmacist provider ; job satisfaction ; job-related preferences ; naltrexone ; medication discrepancies ; interprofessional ; CMS Star rating ; HPV vaccination ; regulatory ; clinical practice ; community pharmacists ; ethical models ; immunization programs ; health policy ; nurse practitioners ; history of pharmacy ; cystic fibrosis ; focus groups ; community pharmacy practice ; gender disparities ; pharmaceutical care practice ; comprehensive medication management ; value ; design thinking ; grants ; value-added services ; pharmacists ; adherence ; implementation ; opioid ; primary health care ; mental health first aid ; pharmacy practice faculty ; community pharmacy services ; comprehensive medication management services ; pharmacy education ; coordinated care ; management ; mental health care ; competitive advantage ; organizations ; Denmark ; naloxone ; compensation ; bic Book Industry Communication::M Medicine
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  • 86
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: A screenshot of some the most rapidly evolving fields in Neonatology and Pediatrics with articles reviewing some metabolic dysregulations as well as non-oncologic diseases that may occur in infancy, childhood, youth. The illustrative material with original photographs and drawings highlighting some pathogenetic concepts are keystones of this book.
    Keywords: R5-920 ; interferon signature score ; interferonopathies ; n/a ; rat model ; pulmonary hypertension ; neurological symptoms ; early-onset sarcoidosis ; sialidosis ; sialidosis I ; children ; mediastinitis ; bilirubin encephalopathy ; Blau syndrome ; myocardial dysfunction ; cardiopulmonary bypass ; neuropathology ; bacteremia ; tissue doppler imaging ; HD-OCT ; biostatistics ; continuous insulin infusion system ; infants ; RNFL ; biomarkers ; diagnosis ; somatosensory evoked potential ; Paediatric sarcoidosis ; diabetic retinopathy ; brain damage ; tonsillectomy ; hybrid closed-loop system ; cytopathology ; neuraminidase ; subcutaneous emphysema ; continuous glucose monitor ; respiratory syncytial virus ; data sharing ; complication ; lysosomal storage disease ; echocardiography ; ONH ; systemic lupus erythematosus ; NT-proBNP ; preterm brain ; head and neck ; inter-laboratory variability ; GSH ; insulin pump ; high-risk sarcoidosis ; type 1 diabetes ; hypoxia-ischemia ; Tei index ; sialidosis II ; mediastinal emphysema ; newborn ; diabetes technology ; diagnostics ; lysosomal exocytosis ; kernicterus ; cerebral palsy ; choroidal thickness ; oxidative stress ; bic Book Industry Communication::M Medicine
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  • 87
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: According to a report from the U.S. Centers for Disease Control and Prevention (CDC), achieving safe and healthier foods was one of the top ten achievements of public health in the 20th century. However, considerable persisting challenges currently exist in developed nations and developing economies for further assuring the safety and security of the food supplies. According to CDC estimates, as many as 3000 American adults, as an example, and based on a recent epidemiological estimate of the World Health Organization, around 420,000 individuals around the globe, lose their lives annually due to foodborne diseases. This emphasizes the need for innovative and emerging interventions, for further prevention or mitigation of the risk of foodborne microbial pathogens during food processing and manufacturing. The current publication discusses recent advancements and progress in the elimination and decontamination of microbial pathogens during various stages of manufacturing and production. Special emphasis is placed on hurdle validation studies, investigating decontamination of non-typhoidal Salmonella enterica serovars, various serogroups of Shiga toxin-producing Escherichia coli, public health-significant serotypes of Listeria monocytogenes, and pathogenic species of Cronobacter.
    Keywords: R5-920 ; RM1-950 ; n/a ; bacteria ; stainless steel ; Escherichia coli ; biofilm formation ; beef ; powdered infant formula ; bile acids ; stx-subtypes ; raw milk ; Shiga toxin-producing Escherichia coli ; Cronobacter sakazakii ; synergism of mild heat and pressure ; raspberry ; blueberry ; biocidal effectiveness ; salmonellosis ; Listeria monocytogenes ; small fruits ; biosensors ; food borne pathogens ; grape ; postharvest diseases ; modified atmosphere packaging ; high hydrostatic pressure ; epithelial barrier ; carvacrol ; dietary bioactive components ; rapid detection ; essential oils ; ozon ; stx-genes ; Cronobacter outbreaks ; habituation ; plant extracts ; Escherichia coli (STEC) ; ozonated water ; disinfectants ; caprylic acid ; foodborne pathogens ; temperature ; natural background microflora ; preventive measures ; carbon dioxide ; nitrogen ; strawberry ; high-pressure pasteurization ; gut microbiota ; food safety ; Shiga toxin-producing Escherichia coli (STEC) ; microfluidic chip ; fungi ; blackberry ; serogroups ; infant care setting ; non-ozonated water ; bic Book Industry Communication::M Medicine
    Language: English
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  • 88
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Arthritis has a high prevalence globally and includes over 100 different types, the most common of which are rheumatoid arthritis, osteoarthritis, psoriatic arthritis, and inflammatory arthritis. The exact etiology of arthritis remains unclear and no cure exists. Anti-inflammatory drugs are commonly used in the treatment of arthritis but are associated with significant side effects. Novel modes of therapy and additional prognostic biomarkers are urgently needed for arthritis patients. This book summarizes and discusses the global picture of the current understanding of arthritis.
    Keywords: R5-920 ; RM1-950 ; receptor activator of nuclear factor ?B ; infliximab ; tripterine ; triptolide ; osteoblast ; tumor necrosis factor-alpha ; synovial cell ; anti-arthritis ; biosimilars ; Epstein-Barr virus ; cytokines ; SOX9 ; parathyroid hormone ; nitric oxide ; rat ; etanercept ; angiogenesis ; glycosylation ; mitogen activated protein kinase ; Th9 lymphocytes ; rheumatoid arthritis ; IL-6 ; clodronate ; bone erosion ; mesenchymal stem cells ; collagen-induced arthritis ; biological ; gene expression ; inflammatory arthritis ; osteoarthritis ; fraxinellone ; nuclear factor kappa B ; messenger RNA ; inflammation ; miRNA ; disease-modifying ; adipokines ; WNT ; glycoprotein 42 ; miR-199a-5p ; proliferation ; next-generation sequencing ; collagen ; osteoarthritis (OA) ; experimental arthritis ; bone morphogenetic protein ; TNF-? ; computational modeling ; basic research ; osteoclast ; therapeutics ; certolizumab pegol ; chondrocytes ; progenitor cells ; adjuvant arthritis ; adalimumab ; triterpenoid ; sclareol ; TNF? ; fibroblast growth factor 2 ; antibodies ; osteoblasts ; molecular pathology ; Th17 ; immunology ; obesity ; visfatin ; articular cartilage ; autoimmune ; biomarkers ; celastrol ; MAPK ; disease pathways ; IL1? ; arthritis ; bioinformatics ; anticitrullinated peptide antibodies ; drug delivery system ; antagonists ; shared epitope ; pathology ; SMA- and MAD-related protein ; small-molecule inhibitor ; transforming growth factor ? ; mice ; golimumab ; spinal fusion ; antirheumatic drug ; early osteoarthritis ; stem cell ; rheumatoid factor ; therapeutic antibody ; bisphosphonate ; osteoclastogenesis ; interleukin ; spondyloarthropathies ; clinical translation ; therapy ; Traditional Chinese medicine ; chemokines ; structure ; cell signaling ; microRNA ; bic Book Industry Communication::M Medicine
    Language: English
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  • 89
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The contribution of genomic variants to the aetiopathogenesis of both paediatric and adult neurological disease is being increasingly recognized. The use of next-generation sequencing has led to the discovery of novel neurodevelopmental disorders, as exemplified by the deciphering developmental disorders (DDD) study, and provided insight into the aetiopathogenesis of common adult neurological diseases. Despite these advances, many challenges remain. Correctly classifying the pathogenicity of genomic variants from amongst the large number of variants identified by next-generation sequencing is recognized as perhaps the major challenge facing the field. Deep phenotyping (e.g., imaging, movement analysis) techniques can aid variant interpretation by correctly classifying individuals as affected or unaffected for segregation studies. The lack of information on the clinical phenotype of novel genetic subtypes of neurological disease creates limitations for genetic counselling. Both deep phenotyping and qualitative studies can capture the clinical and patient’s perspective on a disease and provide valuable information. This Special Issue aims to highlight how next-generation sequencing techniques have revolutionised our understanding of the aetiology of brain disease and describe the contribution of deep phenotyping studies to a variant interpretation and understanding of natural history.
    Keywords: R5-920 ; RC346-429 ; polymicrogyria ; n/a ; neurodegenerative disease ; next generation sequencing (NGS) ; inborn error of metabolism ; genetic biomarker ; deep learning ; TUBA1A ; Alzheimer’s disease (AD) ; ataxia ; risk prediction ; p.(Arg2His) ; movement science ; tubulin ; R2H ; diagnosis ; machine learning ; metal storage disorders ; amyotrophic lateral sclerosis (ALS) ; glucocerebrosidase ; Parkinsonism ; cerebellar hypoplasia ; Gaucher disease ; disease phenotyping ; tubulinopathy ; Parkinson’s disease (PD) ; dementia ; Parkinson’s disease ; bic Book Industry Communication::M Medicine
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  • 90
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: G-quadruplexes (G4s) are nucleic acids secondary structures that form in DNA or RNA guanine (G)-rich strands. In recent years, the presence of G4s in microorganisms has attracted increasing interest. In prokaryotes, G4 sequences have been reported in several human pathogens. Bacterial enzymes able to process G4s have been identified. In viruses, G4s have been suggested to be involved in key steps of the viral life cycle: They have been associated with the human immunodeficiency virus (HIV), herpes simplex virus 1 (HSV-1), human papilloma virus, swine pseudorabies virus, and other viruses’ genomes. New evidence shows the presence of G4s in parasitic protozoa, such as the causative agent of malaria. G4 binding proteins and mRNA G4s have been implicated in the regulation of microorganisms’ genome replication and translation. G4 ligands have been developed and tested both as tools to study the complexity of G4-mediated mechanisms in the viral life cycle and as therapeutic agents. Moreover, new techniques to study G4 folding and their interactions with proteins have been developed. This Special Issue will focus on G4s present in microorganisms, addressing all the above aspects.
    Keywords: R5-920 ; RC109-216 ; bacteria ; folding ; co-translational refolding ; RecQ helicase ; regulatory element ; conformational dynamics ; G4Hunter ; NDPK ; fluorescence ; pseudorabies virus ; Epstein-Barr virus (EBV) ; structure-activity relationship ; PhenDC3 ; eukaryotic hosts ; Herpesvirus ; translation suppression ; turn-on ligands ; co-transcriptional folding ; Herpesviridae ; G-quadruplex ; nucleoside diphosphate kinase ; nucleic acids ; nucleic acids conformation ; bioinformatics ; protein–DNA interaction ; aptamers ; deinococcus ; Alphaherpesvirinae ; EBNA1 ; G4 ; virus ; human papillomaviruses ; S. cerevisiae ; genome stability ; G-quadruplexes ; metastable structure ; genome evolution ; pyridostatin ; alphaherpesviruses ; structure ; protozoa ; genome ; G-quadruplex ligand ; NMR ; microbes ; DNA ; protein-mRNA interactions ; G-quadruplex formation ; immediate early promoters ; bic Book Industry Communication::M Medicine
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  • 91
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The subject of enteral nutrition is an interesting one both to the healthcare professionals working in this practice area and to the individuals who may benefit from nutritional support. These individuals usually have functional guts but may be suffering from dysphagia (with the underlying neurological deficits) or the effects of radiotherapy treatment. Enteral nutrition involves the provision of nutritional support to individuals whose nutritional requirements cannot be met by a normal diet. In particular, it is the process of delivering enteral feed via feeding tubes such nasogastric feeding, nasojejunal and percutaneous endoscopic gastrostomy tubes. Often, enteral nutrition provision involves the assessment of nutritional status, the determination of nutritional requirements, the establishment of feeding regimes, and the management of patients, pumps, feeds, and feeding tubes. Researchers in this field are also keen to evaluate the effect of enteral feeding protocols, algorithms, and guidelines on patients with different medical conditions in various care settings. There have also been a series of comparisons between the use of feeding tubes, feeding methods, and management approaches. Economic evaluations of enteral nutrition and Home Enteral Nutrition (HEN) teams show the benefits of Home Enteral Tube Feeding (HETF); however, due to the rising cost of HETF, there has been intense debate on the subject. There have been reviews on advances, challenges, and prospects in enteral nutrition. This Special Issue is intended to provide information on recent advances in the area of enteral nutrition.
    Keywords: R5-920 ; enteral nutrition ; enteral feeding methods ; enteral feeds ; evaluation of enteral nutrition ; bic Book Industry Communication::M Medicine
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  • 92
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This collection of papers describes the recent development of travel health and vaccination services delivered by pharmacists. It is the first dedicated collection of its type and provides a template for the continued growth of pharmacy practice in this area. The articles examine and report on aspects of such services in the UK, US, Canada, Australia, Switzerland, and South Africa, which will provide useful insight for those in other countries developing such pharmacy-based services.
    Keywords: R5-920 ; RS1-441 ; practice ; education ; vaccinations ; vaccines ; malaria prophylaxis ; pharmacy law ; prescribing and education ; pharmacist ; multidisciplinary collaboration ; training ; travel medicine ; malaria ; travel health ; schedules ; community pharmacy ; pharmacists ; health ; ambulatory care ; community ; Switzerland ; Canada ; pharmacy ; South Africa ; Australia ; travel ; vaccination ; bic Book Industry Communication::M Medicine
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  • 93
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Human papillomavirus (HPV) infections cause approximately 5% of all human cancers. While there are efficacious prophylactic vaccines that prevent infections with the most common cancer-associated HPVs, these vaccines are not widely available in low-resource settings and in many countries, including the US, HPV vaccination rates have remained disappointingly low. Moreover, vaccination does not modify existing HPV infections and the incidence of HPV-associated anal and oropharyngeal cancers has steadily increased and is projected to overtake the caseload of cervical cancer in the next two years. Hence, infections with cancer-associated HPVs will remain a major cause of morbidity and mortality, worldwide. This book provides state-of-the-art summaries and expert viewpoints on unresolved, controversial or emerging topics related to the natural history, evolution, biology, and disease association of papillomavirus infection. The individual chapters cover a wide range of thought provoking topics.
    Keywords: R5-920 ; Cervical Cancer ; Viral Pathogenesis ; human papillomavirus ; Viral Carcinogenesis ; Head and Neck Cancer ; HPV ; bic Book Industry Communication::M Medicine
    Language: English
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  • 94
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue explores the range of clinical manifestations and epidemiology of both skin NTDs and common skin disease in endemic regions, the use of common diagnostic and management pathways, the different technologies that play a role in diagnosis and training, the role of patient involvement at a community level, as well as the assessment of the results of different initiatives in the field.
    Keywords: R5-920 ; RC955-962 ; n/a ; topical corticosteroids ; mental health ; digital handheld microscope ; skin infections ; sporotrichosis Community dermatology ; mHealth ; animal reservoir ; iatrogenic ; case management ; Wet Dermatoscopy (w-DS) ; Mycobacterium ulcerans ; transmission ; neglected tropical diseases ; review ; Enhanced Dermatoscopy (e-DS) ; outbreak ; long range diagnosis ; teledermatology ; Treponema pallidum ; leprosy ; onchocerciasis ; mass drug administration ; point of care test ; scabies ; Africa ; podoconiosis ; Mite-Gallery Unit (MGU) ; diagnosis ; Amerindian communities ; eumycetoma ; community engagement ; clinical presentation ; integration ; onchocercal skin disease ; mycetoma ; PCR ; mobile phone application ; stigma ; resource-poor setting ; slit skin smears ; morbidity management ; training ; tele-expertise ; ivermectin ; eHealth ; NTDs ; Dry Dermatoscopy (d-DS) ; Amazon lowland ; actinomycetoma ; patient involvement ; tropical skin diseases ; surveillance ; yaws ; skin diseases ; skin NTDs ; lymphedema ; Cushing syndrome ; onchodermatitis ; skin disease ; primary health care ; technology ; skin biopsy ; impetigo ; early diagnosis ; dermatology ; telepathology ; drought ; subcutaneous mycosis ; disease mapping ; emergency state ; Entodermoscopy (EDS) ; leprosy diagnosis ; bic Book Industry Communication::M Medicine
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  • 95
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This Special Issue focuses on the synthesis and characterization of hydrogels specifically used as carriers of biological molecules for pharmaceutical and biomedical employments. Pharmaceutical applications of hydrophilic materials has emerged as one of the most significant trends in the area of nanotechnology. To propose some of the latest findings in this field, each contribution involves an in-depth analysis including different starting materials and their physico-chemical and biological properties with the aim of synthetizing high-performing devices for specific use. In this context, intelligent polymeric devices able to be morphologically modified in response to an internal or external stimulus, such as pH or temperature, have been actively pursued. In general, hydrophilic polymeric materials lead to high in vitro and/or in vivo therapeutic efficacy, with programmed site-specific feature showing remarkable potential for targeted therapy. This Special Issue serves to highlight and capture the contemporary progress in this field. Relevant resources and people to approach - American Association Pharmaceutical Scientists (AAPS): web: www.aaps.org; email: (marketing division): Marketing@aaps.org; (mmeting division): Meetings@aaps.org - International Association for Pharmaceutical Technology (APV): web: apv-mainz.de; email (managing director):
    Keywords: R5-920 ; RM1-950 ; polyphenols ; n/a ; sphericity 4 ; injectable hydrogels ; drug delivery ; silk fibroin ; retinol ; “click” chemistry ; amphiphilic copolymers ; pellet diameter 2 ; lacritin ; caffeic acid ; alkyne–azide reaction ; wound healing ; polymer carriers ; thermogravimetric analysis ; lutein ; nanofibers ; ATRP ; gene delivery ; poly(ionic liquid)s ; allantoin ; micellar carriers ; anticancer activity ; crosslinking ; HUVECs ; natural polymers ; sustained release ; graft copolymers ; crystallinity 3 ; equilibrium swelling ratio ; contact lens ; pinocembrin ; bioconjugation ; accumulative release ; nanoporous silicon ; synthetic polymers ; pellets 1 ; self-assemblies ; stimuli-responsive materials ; protein therapeutics ; sodium alginate ; ?CD polymer ; fast release 5 ; star polymers ; extended release 6 ; controlled release ; conjugates ; polyvinyl alcohol ; graft polymers ; elastin-like polypeptide (ELPs) ; bic Book Industry Communication::M Medicine
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  • 96
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: The purpose of these books is to have an updated systematic overview examining, in detail, the functional role of different diets and dietary components in maintaining glucose homeostasis and preventing long-term complications. The first book includes experimental evidence from preclinical research, whereas the second book provides studies in the clinical scenario.
    Keywords: R5-920 ; RC620-627 ; bic Book Industry Communication::M Medicine
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  • 97
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: This text will provide the most recent knowledge and advances in the area of chronic low back pain. The articles will range from topics such as the growing epidemic of chronic low back pain, to intervention for it, as well as specific biopsychosocial characteristics that can be used in its assessment, treatment, and outcomes monitoring.
    Keywords: R5-920 ; functional restoration ; biopsychosocial ; opioid misuse ; chronic low back pain ; interdisciplinary care ; exercise and physical activity ; bic Book Industry Communication::M Medicine
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  • 98
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    MDPI - Multidisciplinary Digital Publishing Institute
    Publication Date: 2023-12-21
    Description: Mycotoxins are secondary metabolites produced by several fungal species. They can contaminate human food and animal feed, and have been a threat for thousands of years. The gastrointestinal tract is the first target when ingesting mycotoxin-contaminated food or feed. As unlikely as it sounds, the investigations concerning the effects of mycotoxins on the intestine are still in their early stages. This book gathers the most recent advances related to the characterization of the intestinal toxicity of mycotoxins. Substantial data assembled on the damage caused to a number of histological structures and functions of the intestine remove any remaining doubt about this organ being a primary target for the toxicity of mycotoxins. An interesting overview of the detrimental effects of mycotoxins on the gut-hosted microbiota—now regarded as a fully-fledged organ associated with the gut—is also given. Finally, outstanding contributions in this book address questions relating to the suitability of current regulations to protect against alterations of the intestine, and to the efficacy assessment of new detoxification strategies using the intestinal toxicity of mycotoxins as a relevant endpoint.
    Keywords: R5-920 ; RA1190-1270 ; toxicity ; intestinal epithelial cells ; n/a ; piglets ; toll-like receptors ; permeability ; aflatoxin M1 ; pig ; N-acetylcysteine ; pigs ; histology ; pre-pubertal gilts ; histopathological lesions ; Mitochondrial apoptosis ; explant technique ; Lactobacillus ; liver ; ergot alkaloids ; digestive tract ; ultrastructure ; hydrogen-rich water ; genotoxicity ; proliferating cell nuclear antigen ; mycotoxin ; feed ; intestinal morphology ; functional oligosaccharides ; Saccharomyces cerevisiae boulardii CNCM I-1079 ; jejunum ; small intestine ; detoxification ; vasoactive intestinal polypeptide ; PCR ; atlantic salmon ; ileum ; microbiota ; sclerotia ; zearalenone ; intestine ; doses ; mycotoxins ; transcriptome ; lipid metabolism ; Zearalenone ; caecal water ; mice ; deoxynivalenol ; aflatoxin B1 ; goblet cells ; inflammation ; intestinal bacterial flora ; SIEC02 cells ; piglet ; colon microbiota ; tight junctions ; tight junction ; suppressor of cytokine signaling ; ochratoxin A ; Claviceps ; T-2 toxin ; MiSeq 16S rDNA sequencing ; lactulose ; Clostridium sp. WJ06 ; swine ; intestinal microbiota ; fumonisin ; response ; contaminated feed ; Fusarium mycotoxins ; microbial diversity ; enteric nervous system ; large intestine ; ultrastructural changes ; oxidative stress ; bic Book Industry Communication::M Medicine
    Language: English
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  • 99
    Publication Date: 2023-12-21
    Description: The prefrontal cortex (PFC) plays a pivotal role in regulating our emotions. The importance of ventromedial regions in emotion regulation, including the ventral sector of the medial PFC, the medial sector of the orbital cortex and subgenual cingulate cortex, have been recognized for a long time. However, it is increasingly apparent that lateral and dorsal regions of the PFC, as well as neighbouring dorsal anterior cingulate cortex, also play a role. Defining the underlying psychological mechanisms by which these functionally distinct regions modulate emotions and the nature and extent of their interactions is a critical step towards better stratification of the symptoms of mood and anxiety disorders. It is also important to extend our understanding of these prefrontal circuits in development. Specifically, it is important to determine whether they exhibit differential sensitivity to perturbations by known risk factors such as stress and inflammation at distinct developmental epochs. This Special Issue brings together the most recent research in humans and other animals that addresses these important issues, and in doing so, highlights the value of the translational approach.
    Keywords: R5-920 ; RC321-571 ; norepinephrine ; medial prefrontal cortex ; fear extinction ; emotion regulation ; emotion processing ; connectivity ; anticipatory arousal ; Pavlovian ; triadic neural systems model ; prelimbic ; development ; positive and negative ; rat ; Williams Syndrome ; psychological treatment ; glia density ; anxiety ; fMRI ; area 25 ; anhedonia ; adolescence ; adolescent ; autonomic ; amygdala ; neuron density ; neural ; prefrontal cortex ; reliability ; functional magnetic resonance imaging (fMRI) ; networks ; cAMP ; cognitive control ; extinction ; infralimbic ; NMDA ; reward ; calcium ; stress adolescence ; BDNF ; machine learning ; negative affect ; hierarchical control ; emotion ; occasion setting ; serotonin transporter ; ventromedial prefrontal cortex ; psychophysiology ; depression ; aging ; dopamine ; age ; bic Book Industry Communication::M Medicine
    Language: English
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  • 100
    Publication Date: 2024-03-30
    Description: This Special Issue of the International Journal of Molecular Science comprises a comprehensive study on “Metal Complex Interactions with Nucleic Acids and/or DNA”. This Special Issue has been inspired by the important contribution of Prof. Nick Hadjiliadis to the field of palladium or/and platinum/nucleic acid interactions. It covers a selection of recent research and review articles in the field of metal complex interactions with nucleic acids and/or DNA. Moreover, this Special Issue on "Metal Complexes Interactions with Nucleic Acids and/or DNA" provides an overview of this increasingly diverse field, presenting recent developments and the latest research with particular emphasis on metal-based drugs and metal ion toxicity.
    Keywords: R5-920 ; QH301-705.5 ; RM1-950 ; QD415-436 ; Metal-based drugs ; Platinum complexes anticancer agents ; Non-platinum metal complexes anticancer agents ; Metal complexes interactions with nucleic acids ; Inorganic Biochemistry ; Metal complexes interactions with DNA
    Language: English
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