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  • Frontiers Media SA  (2,449)
  • Taylor & Francis  (1,650)
  • Springer Nature  (1,606)
  • Routledge  (1,171)
  • Open Book Publishers  (319)
  • Amsterdam : Elsevier
  • Washington, DC : United States Gov. Print. Off.
  • English  (6,079)
  • 2020-2024  (6,075)
  • 2005-2009  (4)
  • 1995-1999
  • 2021  (6,075)
  • 2005  (4)
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  • 2020-2024  (6,075)
  • 2005-2009  (4)
  • 1995-1999
Year
  • 1
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: social-decision making ; animal behavior ; behavioral ecology ; animal collective behavior ; animal SDM ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 2
    Publication Date: 2023-12-20
    Description: This book presents the most current research results and knowledge from five multidisciplinary themes: Vulnerability of Arctic Environments, Vulnerability of Arctic Societies, Local and Traditional Knowledge, Building Long-term Human Capacity, New Markets for the Arctic, including tourism and safety. The themes are those discussed at the first ever UArctic Congress Science Section, St. Petersburg, Russia, September 2016. The book looks at the Arctic from a holistic perspective; how the environment (both marine and terrestrial) and communities can adapt and manage the changes due to climate change. The chapters provide examples of the state-of-the-art research, bringing together both scientific and local knowledge to form a comprehensive and cohesive volume.
    Keywords: GE1-350 ; environment ; tourism ; vulnerability ; Arctic ; indigenous knowledge ; marine and terrestrial polar landscapes ; climate change ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics
    Language: English
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  • 3
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    Taylor & Francis | The Transformation of Yunnan in Ming China | Routledge
    Publication Date: 2023-09-12
    Description: This book examines how the Ming state transformed the multi-ethnic society of Yunnan into a province. Yunnan had remained outside the ambit of central government when ruled by the Dali kingdom, 937-1253, and its foundation as a province by the Yuan regime in 1276 did not disrupt Dali kingdom style political, social and religious institutions. It was the Ming state in the fourteenth to seventeenth centuries through its institutions for military and civilian control which brought about profound changes and truly transformed local society into a province. In contrast to other studies which have portrayed Yunnan as a non-Han frontier region waiting to be colonised, this book, by focusing on changes in local society, casts off the idea of Yunnan as a border area far from civilisation.
    Keywords: Yunnan, Ming China ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBC Social research & statistics
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  • 4
    Publication Date: 2024-04-05
    Description: After a quarter of century of rapid technological advances, research has revealed the complexity of cancer, a disease intimately related to the dynamic transformation of the genome. However, the full understanding of the molecular onset of this disease is still far from achieved and the search for mechanisms of treatment will follow closely. It is here that Nanotechnology enters the fray offering a wealth of tools to diagnose and treat cancer. In fact, the National Cancer Institute predicts that over the next years, nanotechnology will result in important advances in early detection, molecular imaging, targeted and multifunctional therapeutics, prevention and control of cancer. Nanotechnology offers numerous tools to diagnose and treat cancer, such as new imaging agents, multifunctional devices capable of overcome biological barriers to deliver therapeutic agents directly to cells and tissues involved in cancer growth and metastasis, and devices capable of predicting molecular changes to prevent action against precancerous cells. Nanomaterials-based delivery systems in Theranostics (Diagnostics & Therapy) provide better penetration of therapeutic and diagnostic substances within the body at a reduced risk in comparison to conventional therapies. At the present time, there is a growing need to enhance the capability of theranostics procedures where nanomaterials-based sensors may provide for the simultaneous detection of several gene-associated conditions and nanodevices with the ability to monitor real-time drug action. These innovative multifunctional nanocarriers for cancer theranostics may allow the development of diagnostics systems such as colorimetric and immunoassays, and in therapy approaches through gene therapy, drug delivery and tumor targeting systems in cancer. Some of the thousands and thousands of published nanosystems so far will most likely revolutionize our understanding of biological mechanisms and push forward the clinical practice through their integration in future diagnostics platforms. Nevertheless, despite the significant efforts towards the use of nanomaterials in biologically relevant research, more in vivo studies are needed to assess the applicability of these materials as delivery agents. In fact, only a few went through feasible clinical trials. Nanomaterials have to serve as the norm rather than an exception in the future conventional cancer treatments. Future in vivo work will need to carefully consider the correct choice of chemical modifications to incorporate into the multifunctional nanocarriers to avoid activation off-target, side effects and toxicity. Moreover the majority of studies on nanomaterials do not consider the final application to guide the design of nanomaterial. Instead, the focus is predominantly on engineering materials with specific physical or chemical properties. It is imperative to learn how advances in nanosystem’s capabilities are being used to identify new diagnostic and therapy tools driving the development of personalized medicine in oncology; discover how integrating cancer research and nanotechnology modeling can help patient diagnosis and treatment; recognize how to translate nanotheranostics data into an actionable clinical strategy; discuss with industry leaders how nanotheranostics is evolving and what the impact is on current research efforts; and last but not least, learn what approaches are proving fruitful in turning promising clinical data into treatment realities.
    Keywords: QD1-999 ; Q1-390 ; Nanoparticles ; Gene Therapy ; Immunotherapy ; bioimaging ; theranostics ; nanomaterials ; Drug delivery ; Nanomedicine ; Cancer ; Phototherapy ; thema EDItEUR::P Mathematics and Science::PN Chemistry
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  • 5
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    Springer Nature
    Publication Date: 2022-01-31
    Description: The world is faced with an epidemic of metabolic diseases such as obesity and type 2 diabetes. This is due to changes in dietary habits and the decrease in physical activity. Exercise is usually part of the prescription, the first line of defense, to prevent or treat metabolic disorders. However, we are still learning how and why exercise provides metabolic benefits in human health. This open access volume focuses on the cellular and molecular pathways that link exercise, muscle biology, hormones and metabolism. This will include novel “myokines” that might act as new therapeutic agents in the future.
    Keywords: RC648-665 ; RC620-627 ; human brown adipose tissue plasticity ; type 2 diabetes ; Tryptophan-kynurenine metabolites ; metabolic diseases ; muscle glycogen ; AMPK ; skeletal muscle microRNAs ; FNDC5/irisin ; obesity
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  • 6
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    Taylor & Francis | CRC Press
    Publication Date: 2024-04-14
    Description: Going beyond current books on privacy and security, this book proposes specific solutions to public policy issues pertaining to online privacy and security. Requiring no technical or legal expertise, it provides a practical framework to address ethical and legal issues. The authors explore the well-established connection between social norms, privacy, security, and technological structure. They also discuss how rapid technological developments have created novel situations that lack relevant norms and present ways to develop these norms for protecting informational privacy and ensuring sufficient information security.
    Keywords: CHOICE Highly Recommended Title ; Data Preparation and Mining ; IT Security ; Cryptology ; InfoSECURITY ; SCI-TECH ; COMPUTERSCIENCE ; ITECH ; INFORMATIONSCIENCE ; STM ; deep ; defense ; inspection ; malware ; norm ; optimal ; packet ; perfect ; software ; vulnerabilities ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMK Games development and programming ; thema EDItEUR::U Computing and Information Technology::UN Databases::UNF Data mining ; thema EDItEUR::U Computing and Information Technology::UR Computer security ; thema EDItEUR::U Computing and Information Technology::UR Computer security::URY Data encryption
    Language: English
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  • 7
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: omics ; epigenetics ; pharmacogenetics ; CYP ; risk prediction ; microbiota ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKG Pharmacology
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  • 8
    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 9
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    Taylor & Francis | Classical Heritage and European Identities | Routledge
    Publication Date: 2024-04-01
    Description: This book examines how different agents and institutions within the Danish nation state have situated themselves within this complex landscape of competing appropriations of classical antiquity from the eighteenth century to the present day. In particular, it focuses on the use of classical heritages to construct both European and national identities (in the plural) and especially on how Danes in this period have engaged with a sense of European commonality through their engagements with the classical past.
    Keywords: Classical heritage ; European identities ; Europe ; Danish nation ; Denmark ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 10
    Publication Date: 2024-04-01
    Description: This book is a reflection on the politics of heritage in Europe at the present time, in a moment of pluralised conceptions of the political, social and demographic organisation proper to Europe. It is not a book that seeks to survey, define or characterise an enduring ‘European heritage’ as an entity, but rather to explore what heritage does – how it is understood, instrumentalised and what it enables – within what we will argue is a ‘critical’ moment for both identities and geopolitics in Europe.
    Keywords: European heritage ; political organisation ; social organisation ; demographic organisation ; Europe ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general
    Language: English
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  • 11
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: oligodendrocyte ; Schwann cell ; oligodendrocyte precursor cell ; myelin ; myelin repair ; axon physiology ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 12
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
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  • 13
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-08
    Description: The Orthodox Christian tradition has all too often been sidelined in conversations around contemporary religion. Despite being distinct from Protestantism and Catholicism in both theology and practice, it remains an underused setting for academic inquiry into current lived religious practice. This collection, therefore, seeks to redress this imbalance by investigating modern manifestations of Orthodox Christianity through an explicitly gender-sensitive gaze. By addressing attitudes to gender in this context, it fills major gaps in the literature on both religion and gender. Starting with the traditional teachings and discourses around gender in the Orthodox Church, the book moves on to demonstrate the diversity of responses to those narratives that can be found among Orthodox populations in Europe and North America. Using case studies from several countries, with both large and small Orthodox populations, contributors use an interdisciplinary approach to address how gender and religion interact in contexts such as, iconography, conversion, social activism and ecumenical relations, among others. From Greece and Russia to Finland and the USA, this volume sheds new light on the myriad ways in which gender is manifested, performed, and engaged within contemporary Orthodoxy. Furthermore, it also demonstrates that employing the analytical lens of gender enables new insights into Orthodox Christianity as a lived tradition. It will, therefore, be of great interest to scholars of both Religious Studies and Gender Studies.
    Keywords: Gender, Identity ; Christianity ; Women ; Religious ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups::QRMB2 Orthodox and Oriental Orthodox Churches ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRV Aspects of religion::QRVP Religious life and practice::QRVP7 Religious aspects of sexuality, gender and relationships ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRM Christianity::QRMB Christian Churches, denominations, groups::QRMB2 Orthodox and Oriental Orthodox Churches ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRV Aspects of religion::QRVP Religious life and practice::QRVP7 Religious aspects of sexuality, gender and relationships ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSR Social groups: religious groups and communities
    Language: English
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  • 14
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    Open Book Publishers
    Publication Date: 2024-03-24
    Keywords: critical edition ; translation ; ovid ; metamorphoses ; Bavarian commentary ; ancient literature ; medieval readers ; Munich Bayerische Staatsbibliothek clm 4610 ; thema EDItEUR::D Biography, Literature and Literary studies::DB Ancient, classical and medieval texts ; thema EDItEUR::D Biography, Literature and Literary studies::DC Poetry::DCF Poetry by individual poets ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFP Translation and interpretation
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  • 15
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    Taylor & Francis | Environmental Policy in the EU | Routledge
    Publication Date: 2023-09-12
    Description: The European Union (EU) has a hugely important effect on the way in which environmental policies are framed, designed and implemented in many parts of the world, but especially Europe. The new edition of this leading textbook provides a state-of-the-art analysis of the EU’s environmental policies. Comprising five parts, Environmental Policy in the EU covers the rapidly changing context in which EU environmental policies are made, the key actors who interact to co-produce them and the most salient dynamics of policy making, ranging from agenda setting and decision making, through to implementation and evaluation. Written by leading international experts, individual chapters examine how the EU is responding to a multitude of different challenges including biodiversity loss, climate change, energy insecurity, and water and air pollution. They tease out the different ways in which the EU’s policies on these topics co-evolve with national and international environmental policies. In this systematically updated fourth edition, a wider array of learning features are employed to ensure that readers fully understand how EU environmental policies have developed over the last fifty years and how they are currently adapting to the rapidly evolving challenges of the twenty-first century, including the COVID-19 pandemic. It is an essential resource for undergraduate and postgraduate students studying environmental policy and politics, climate change, environmental law and EU politics more broadly.
    Keywords: Brexit; Climate Change; Energy security; Europe; European Union; European Parliament; Governance; Global Environmental Policy ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNK Environment, transport & planning law::LNKJ Environment law ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNC Applied ecology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RND Environmental policy & protocols
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  • 16
    Publication Date: 2024-04-05
    Description: In the past two decades there have been significant advances made in understanding the cellular and molecular alterations that occur with brain ageing, as well as with our understanding of age-related brain diseases. Ageing is associated with a mid-life decline in many cognitive domains (eg. Attention, working memory, episodic memory) that progresses with advancing age and which may be potentiated by a variety of diseases. However, despite the breadth of attempts to explain it, the underlying basis for age-related memory impairment remains poorly understood. Both normal and “pathological” ageing (as in age-related neurodegenerative disorders such as Alzheimer’s disease) may be associated with overlapping and increased levels of “abnormal” pathology, and this may be a potential mediator of cognitive decline in both populations. An emerging hypothesis in this field is that metal ion dys/homeostasis may represent a primary unifying mechanism to explain age- and disease-associated memory impairment – either indirectly via an effect on disease pathogenesis, or by a direct effect on signaling pathways relevant to learning and memory. There remains a concerted worldwide effort to deliver an effective therapeutic treatment for cognitive decline associated with ageing and/or disease, which is currently an unmet need. There have been numerous clinical trials conducted specifically testing drugs to prevent cognitive decline and progression to dementia, but to date the results have been less than impressive, highlighting the urgent need for a greater understanding of the neurobiological basis of memory impairment in ageing and disease which can then drive the search for effective therapeutics.
    Keywords: RC321-571 ; Q1-390 ; Down Syndrome ; Amyotrophic Lateral Sclerosis ; Parkinson's disease ; aluminium ; Iron ; TBI ; Cognition ; Copper ; Alzheimer's disease ; Zinc ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 17
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-14
    Description: This book introduces a new mechanism for representing social networks in which pairwise relationships can be drawn from a range of realistic possibilities, including different types of relationships, different strengths in the directions of a pair, positive and negative relationships, and relationships whose intensities change with time. For each possibility, the book shows how to model the social network using spectral embedding. It also shows how to compose the techniques so that multiple edge semantics can be modeled together. The modeling techniques are then applied to a range of datasets to show how they can produce results that are useful in understanding real-world social networks.
    Keywords: Computer Science ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics::UBW Internet: general works
    Language: English
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  • 18
    Publication Date: 2024-04-04
    Description: Evolution of the horse has been an often-cited primary example of evolution, as well as one of the classic and important stories in paleontology for over a century and a half, due to their rich fossil record across 5 continents: North America, South America, Europe, Asia and Africa. The recent horse has served a profound role in human ancestry, including agriculture, commerce, sport, transport, warfare, and in prehistory, for the subsistence of humans. Many studies have examined the evolution of the Equidae and chronicled the striking changes in skulls, dentition, limbs, and body size which have long been perceived to be a response to environmental shifts through time. Most comprehensive studies heretofore have: (1) focused on the “Great Transformation”- changes that occurred in the early Miocene, (2) involved tracking long-term diversity or paleoecological trends on a single continent or within a geographical locality, or (3) concentrated on the 3-toed hipparions. The Plio–Pleistocene evolutionary stage of horse evolution is punctuated by the great climatic fluctuations of the Quaternary beginning 2.6 Ma which influenced Equus evolution, biogeographic dispersion and adaptation on a nearly global scale. The evolutionary biology of Equus evolution across its entire range remains relatively poorly understood and often highly controversial. Some of this lack of understanding is due to assumptions that have arisen because of the relatively derived craniodental and postcranial anatomy of Equus and its close relatives which has seemed to imply that that these forms occupied relatively homogenous and narrow dietary and locomotor niches - notions that have not been adequately addressed and rigorously tested. Other challenges have revolved around teasing apart environmentally-driven adaptation versus phylogenetically defined morphological change. Geochronologic age control of localities, geographic provinces and continents has improved, but in no way is absolute and can be reexamined in our proposed volume. Temporal resolution for paleodietary, paleohabitat and paleoecological interpretations are also challenging for understanding the evolution of Equus. Our proposed volume attempts to assemble a group of experts who will address multiple dimensions of Equus’ evolution in time and space.
    Keywords: Ecomorphology ; Equus ; Paleoecology ; Taxonomy ; Biogeography ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere
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  • 19
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
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  • 20
    Publication Date: 2024-04-05
    Description: Neuromorphic engineering has just reached its 25th year as a discipline. In the first two decades neuromorphic engineers focused on building models of sensors, such as silicon cochleas and retinas, and building blocks such as silicon neurons and synapses. These designs have honed our skills in implementing sensors and neural networks in VLSI using analog and mixed mode circuits. Over the last decade the address event representation has been used to interface devices and computers from different designers and even different groups. This facility has been essential for our ability to combine sensors, neural networks, and actuators into neuromorphic systems. More recently, several big projects have emerged to build very large scale neuromorphic systems. The Telluride Neuromorphic Engineering Workshop (since 1994) and the CapoCaccia Cognitive Neuromorphic Engineering Workshop (since 2009) have been instrumental not only in creating a strongly connected research community, but also in introducing different groups to each other’s hardware. Many neuromorphic systems are first created at one of these workshops. With this special research topic, we showcase the state-of-the-art in neuromorphic systems.
    Keywords: RC321-571 ; Q1-390 ; neuromorphic engineering ; Learning ; Floating gate ; Neural Network ; spike-based ; event-based ; simulation ; dynamic vision sensor ; network ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 21
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 22
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Despite the importance of mathematics in our educational systems little is known about how abstract mathematical thinking emerges. Under the uniting thread of mathematical development, we hope to connect researchers from various backgrounds to provide an integrated view of abstract mathematical cognition. Much progress has been made in the last 20 years on how numeracy is acquired. Experimental psychology has brought to light the fact that numerical cognition stems from spatial cognition. The findings from neuroimaging and single cell recording experiments converge to show that numerical representations take place in the intraparietal sulcus. Further research has demonstrated that supplementary neural networks might be recruited to carry out subtasks; for example, the retrieval of arithmetic facts is done by the angular gyrus. Now that the neural networks in charge of basic mathematical cognition are identified, we can move onto the stage where we seek to understand how these basics skills are used to support the acquisition and use of abstract mathematical concepts.
    Keywords: RC321-571 ; Q1-390 ; Neuroimaging ; development ; numerosity ; gifted ; Mathematical Cognition ; algebra ; abstract ; Expertise ; Arithmetic ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 23
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: E-commerce offers immense challenges to traditional dispute resolution methods, as it entails parties often located in different parts of the world making contracts with each other at the click of a mouse. The use of traditional litigation for disputes arising in this forum is often inconvenient, impractical, time-consuming and expensive due to the low value of the transactions and the physical distance between the parties. Thus modern legal systems face a crucial choice: either to adopt traditional dispute resolution methods that have served the legal systems well for hundreds of years or to find new methods which are better suited to a world not anchored in territorial borders. Online Dispute Resolution (ODR), originally an off-shoot of Alternative Dispute Resolution (ADR), takes advantage of the speed and convenience of the Internet, becoming the best, and often the only option for enhancing consumer redress and strengthening their trust in e-commerce. This book provides an in-depth account of the potential of ODR for European consumers, offering a comprehensive and up to date analysis of the development of ODR. It considers the current expansion of ODR and evaluates the challenges posed in its growth. The book proposes the creation of legal standards to close the gap between the potential of ODR services and their actual use, arguing that ODR, if it is to realise its full potential in the resolution of e-commerce disputes and in the enforcement of consumer rights, must be grounded firmly on a European regulatory model. Introduction 1. Consumer Protection and Access to Justice in the E-Commerce Era: A European Perspective 2. Online Dispute Resolution as a Consumer Redress Strategy 3. Consumer Adjudicative Processes Supported by ICT: Court Processes and Arbitration 4. Online Mediation for Consumers: The Way Forward 5. The Need for a Legal Framework to Develop Consumer ODR in the EU
    Keywords: law ; dispute resolution ; information technology ; e-commercie ; information technology law ; commercial law ; e-commerce ; commercieel recht ; informatie technologie ; informatie technologie recht ; recht ; Alternative dispute resolution ; Arbitration ; Consumer protection ; European Union ; Mediation ; Online dispute resolution ; Uniform Domain-Name Dispute-Resolution Policy ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KNT Media, information & communication industries::KNTX Information technology industries ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNC Company, commercial & competition law::LNCB Commercial law ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNC Company, commercial & competition law::LNCB Commercial law::LNCB2 E-commerce law
    Language: English
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  • 24
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 25
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Exercise Science ; Performance ; Physiology ; Japan ; Olympics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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  • 26
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-08
    Description: This edited collection explores the agency of women who do violence and have violence done to them. Topics covered include rape, pornography, prostitution, suicide bombing and domestic violence. The volume contributes to the philosophical and theoretical debate, as well as offering practical, social and political responses to the issues examined.
    Keywords: violence ; prostitution ; suicide bombing ; women ; rape ; pornography ; domestic violence ; bic Book Industry Communication::H Humanities::HP Philosophy::HPQ Ethics & moral philosophy ; bic Book Industry Communication::H Humanities::HP Philosophy::HPS Social & political philosophy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFK Feminism & feminist theory ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKV Crime & criminology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTQ Ethics and moral philosophy ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTS Social and political philosophy ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls::JBSF11 Feminism and feminist theory ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology
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    Taylor & Francis | CRC Press
    Publication Date: 2023-09-12
    Description: The complex regulations of the Endangered Species Act established by the U.S. Fish and Wildlife Service can be challenging for environmental professionals who must comply with them or assist clients in compliance. This is true especially for those without a background in biology or ecology. The Endangered Species Act: History, Implementation, Successes, and Controversies discusses the Act using clear scientific prose that all professionals whose activities fit into the ESA compliance process can readily comprehend, including those with limited education in science. The book begins by exploring the deeply rooted history of the Endangered Species Act, which extends back decades preceding its enactment in 1973. It continues with a discussion of the basic scientific theory underlying the Act and provides an overview of its key regulations. The author also examines the Act in the context of other key environmental planning statutes such as the National Environmental Policy Act and the Clean Water Act, especially Section 404 of the Clean Water Act, which relates specifically to wetlands. The remainder of the book details the regulatory processes faced by other government agencies and private developers who must routinely ensure that their actions comply with the Endangered Species Act. It concludes with a broad discussion of current controversies associated with the Act and how those controversies might ultimately change how environmental practitioners will have to comply with the Act in the future. The book is neither a defense of the Endangered Species Act and its associated regulations nor a call to repeal or modify the Act or regulations. The presentation is factual and avoids the hype and hyperbole commonly directed at the Act by both environmental activists and deregulation proponents. Readers will gain a solid understanding of how the Act was established, what goals were envisioned by its framers, how current environmental practice under the Act has been shaped, and how those practices might be changed in the future.
    Keywords: Environment law ; Applied ecology ; Biology ; life sciences ; Zoology & animal sciences ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNK Environment, transport & planning law::LNKJ Environment law ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNC Applied ecology ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSV Zoology & animal sciences
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  • 28
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: organohalide respiration ; Microbial reductive dehalogenation ; Dehalococcoides ; electron transport chain ; reductive dehalogenase ; Community composition and function ; bioremediation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 29
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: artificial reefs ; offshore oil and gas platforms ; coastal infrastructure ; aquaculture facilities ; anthropogenic influences ; ecological restoration ; marine conservation ; rigs-to-reef ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RB Earth sciences::RBK Hydrology and the hydrosphere::RBKC Oceanography (seas and oceans)
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  • 30
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 31
    Publication Date: 2024-03-29
    Description: In the year 2013, ‘selfie’ was named word of the year by Oxford Dictionaries in recognition of dramatic changes in frequency, prominence, and register of the term. This drastic increase in selfie-taking was spurred by two factors. The first was the advent of smartphones equipped with front cameras and preview screens that made it easy to compose a photographic self-portrait by a process of deliberately exploring one’s image, choosing a pose, and finally taking the picture. The second key change contributing to the rise of the selfie age was the increasing availability of internet connections. It is estimated that about 50% of the world population has access to the internet today (2018; https://www.internetworldstats.com). At the end of the past century, this percentage was a mere 1%. The growth of the internet infrastructure simultaneously spurred the development of social network applications such as Facebook, Twitter, Snapchat, and Instagram, providing accessible media for sharing photographs including photographic self-portraits. However, despite their tremendous reach and popularity, selfies have so far received relatively little attention by the scientific community, especially within psychology. Thus, we proposed a Frontiers in Psychology Research Topic to expand empirical and theoretical work on the massively popular, yet scientifically unexplored, phenomenon of the selfie. The articles published in this eBook offer a multifaceted insight into current scholarly work on this topic.
    Keywords: BF1-990 ; Q1-390 ; group selfies ; self-esteem ; Human Computer Interaction (HCI) ; self-presentation ; selfie ; viewing perspective ; perception bias ; smartphones ; social media ; internet ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 32
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This open access book makes a contribution to our understanding of one of the social challenges facing many western nations i.e. the challenge of an ageing population. It specifically addresses the issue of competence among older employees. Others have studied ageing populations in terms of the economic burden or the pressure on healthcare services and generally view the rising numbers of seniors more as a challenge than an opportunity. In this book, authors discuss ways of gaining positive benefits from our ageing and more experienced work force.
    Keywords: older employees ; active ageing ; lifelong learning ; competence ; ageing workers ; late careers ; Open Access ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBL Sociology: work and labour ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBK Sociology: family and relationships
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  • 33
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    Springer Nature | Springer International Publishing
    Publication Date: 2021-02-10
    Description: This third and last open access volume in the series takes the perspective of non-EU countries on immigrant social protection. By focusing on 12 of the largest sending countries to the EU, the book tackles the issue of the multiple areas of sending state intervention towards migrant populations. Two “mirroring” chapters are dedicated to each of the 12 non-EU states analysed (Argentina, China, Ecuador, India, Lebanon, Morocco, Russia, Senegal, Serbia, Switzerland, Tunisia, Turkey). One chapter focuses on access to social benefits across five core policy areas (health care, unemployment, old-age pensions, family benefits, guaranteed minimum resources) by discussing the social protection policies that non-EU countries offer to national residents, non-national residents, and non-resident nationals. The second chapter examines the role of key actors (consulates, diaspora institutions and home country ministries and agencies) through which non-EU sending countries respond to the needs of nationals abroad. The volume additionally includes two chapters focusing on the peculiar case of the United Kingdom after the Brexit referendum. Overall, this volume contributes to ongoing debates on migration and the welfare state in Europe by showing how non-EU sending states continue to play a role in third country nationals’ ability to deal with social risks. As such this book is a valuable read to researchers, policy makers, government employees and NGO’s.
    Keywords: Social Sciences, general ; Microeconomics ; Social Policy ; Sociology of Migration ; Open access ; Non-EU countries ; Immigrant social protection ; Migrant populations ; Argentina, China, Ecuador, India ; Lebanon, Morocco, Russia ; Senegal, Serbia, Switzerland ; Tunisia, Turkey ; Health care ; Unemployment ; Old-age pensions ; Guaranteed minimum resources ; Family benefits ; Migration and integration ; Sending states ; Society & Social Sciences ; Sociology ; Political economy ; Social & ethical issues ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCC Microeconomics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy
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  • 34
    Publication Date: 2024-04-14
    Description: Computer science
    Keywords: Computer science ; thema EDItEUR::U Computing and Information Technology::UY Computer science
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: resting-state fMRI ; fMRI denoising ; vascular modulation ; head motion ; arousal ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: The Gender-Sensitive University explores the prevailing forces that pose obstacles to driving a gender-sensitive university, which include the emergence of far-right movements that seek to subvert advances towards gender equality and managerialism that promotes creeping corporatism. This book demonstrates that awareness of gender equality and gender sensitivity are essential for pulling contemporary academia back from the brink. New forms of leadership are fundamental to reforming our institutions. The concept of a gender-sensitive university requires re-envisioning academia to meet these challenges, as does a different engagement of men and a shift towards fluidity in how gender is formulated and performed. Academia can only be truly gender-sensitive if, learning from the past, it can avoid repeating the same mistakes and addressing existing and new biases. The book chapters analyse these challenges and advocate the possibilities to ‘fix it forward’ in all areas. Representing ten EU countries and multiple disciplines, contributors to this volume highlight the evidence of persistent gender inequalities in academia, while advocating a blueprint for addressing them. The book will be of interest to a global readership of students, academics, researchers, practitioners, academic and political leaders and policy makers who share an interest in what it takes to establish gender-sensitive universities.
    Keywords: EU ; Europe ; GEPs ; gender ; equality ; university ; gender bias ; inequality ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology
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  • 38
    Publication Date: 2024-03-28
    Description: The book contains essays on current issues in Social and Political Sciences, such as the issues of governance and social order; social development and community development; global challenges and inequality; civil society and social movement; IT-based community and social transformation; poverty alleviation and corporate social responsibility; and gender issues. Asia and the Pacific are the particular regions that the conference focuses on as they have become new centers of social and political development. Therefore, this book covers areas that have been traditionally known as the social and political areas such as communication studies, political studies, governance studies, criminology, sociology, social welfare, anthropology and international relations. The book will help shed light on what social and political scholars in Asia and the Pacific have done in terms of research and knowledge development, as well as the new frontiers of research that have been explored and opening up, which can connect the two regions with the rest of the globe.
    Keywords: politics ; social sciences ; international relations ; Indonesia ; thema EDItEUR::J Society and Social Sciences
    Language: English
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    Springer Nature
    Publication Date: 2024-03-23
    Description: This book explores the interrelation between diversity in migrants’ internal relations and their experience of inequality in local and global contexts. Taking the case of Hamburg-based Iranians, it traces evaluation processes in ties between professionals – artists and entrepreneurs – since the 1930s, examining migrants’ potential to act upon hierarchical structures. Building on long-term ethnographic fieldwork and archival work, the book centers on differentiation, combining a diversity study with a focus on locality, with a transnational migration study, analysing strategies of capital creation and anthropological value theory. The analysis of migrants’ agency tackles questions of independence and cooperation in kinship, associations, transnational entrepreneurship and cultural events within the context of the position of Germany and Iran in the global politico-economic landscape. This material will be of interest to scholars and students of anthropology, sociology, migration, urbanism and Iranian studies, as well as Iranian-Germans and those interested in the entanglement of global and local power relations.
    Keywords: Social sciences ; Emigration and immigration ; Emigration and immigration ; Ethnography ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFH Migration, immigration and emigration ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PB Relating to peoples: ethnic groups, indigenous peoples, cultures and other groupings of people::5PBC Relating to migrant groups / diaspora communities or peoples ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: English
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    Springer Nature | Springer
    Publication Date: 2024-04-08
    Description: This book is open access under a CC BY 4.0 license. This book addresses the age-old problem of infinite regresses in epistemology. How can we ever come to know something if knowing requires having good reasons, and reasons can only be good if they are backed by good reasons in turn? The problem has puzzled philosophers ever since antiquity, giving rise to what is often called Agrippa's Trilemma. The current volume approaches the old problem in a provocative and thoroughly contemporary way. Taking seriously the idea that good reasons are typically probabilistic in character, it develops and defends a new solution that challenges venerable philosophical intuitions and explains why they were mistakenly held. Key to the new solution is the phenomenon of fading foundations, according to which distant reasons are less important than those that are nearby. The phenomenon takes the sting out of Agrippa's Trilemma; moreover, since the theory that describes it is general and abstract, it is readily applicable outside epistemology, notably to debates on infinite regresses in metaphysics. The book is a potential game-changer and a must for any advanced student or researcher in the field.
    Keywords: Epistemology ; Mathematical Logic and Foundations ; Statistical Theory and Methods ; History and Philosophical Foundations of Physics ; Operations Research/Decision Theory ; Philosophical Foundations of Physics and Astronomy ; Operations Research and Decision Theory ; Epistemic Justification ; Infinite Regress ; Regresses in Epistemology ; Regresses in Ethics ; Regresses in Metaphysics ; Regresses in Philosophy of Mind ; Open Access ; Philosophy: epistemology & theory of knowledge ; Mathematical foundations ; Mathematical logic ; Probability & statistics ; History of science ; Operational research ; Management decision making ; bic Book Industry Communication::H Humanities::HP Philosophy::HPK Philosophy: epistemology & theory of knowledge ; bic Book Industry Communication::P Mathematics & science::PB Mathematics::PBC Mathematical foundations ; bic Book Industry Communication::P Mathematics & science::PB Mathematics::PBT Probability & statistics ; bic Book Industry Communication::P Mathematics & science::PD Science: general issues::PDX History of science ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJT Operational research ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTK Philosophy: epistemology and theory of knowledge ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBC Mathematical foundations ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBT Probability and statistics ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJT Operational research
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    Taylor & Francis | International Perspectives on Writing Curricula and Development | Routledge
    Publication Date: 2023-09-12
    Description: This chapter analyses how writing and writing development has been and currently is prescribed and enacted in the curriculum for Danish as a subject (L1) in Years 1–9. Highlighting historical points of impact for writing in curricula from the early–nineteenth century through frequent reforms in the twentieth and twenty-first centuries, we focus empirically on the 2014 ruling curricular document Common Standards and auxiliary documents framing writing assessment at the school-leaving exam, as well as empirical classroom studies. Analyses of steering documents indicate that there has been an unprecedented push towards outcome-based and competence-oriented writing curricula. Following Ivanič's Discourses of Writing (DoW) framework, process writing is found to be the most dominant discourse from Grades 1–7. The analysis of the enacted writing curriculum, which focuses on empirical studies from 2009 until now, reveals that the enacted curriculum is misaligned with the prescriptive curriculum and tends to position the student in ambiguous ways—from joyful writer to a writer tested in high-stakes exams. For discussion, we call for a more coherent writing curriculum. Methodologically, we argue that the DoW framework needs to be complemented with a Nordic Bildung tradition, which accentuates personal formation, and a multimodal framework informing the Danish curriculum.
    Keywords: writing studies, writing development, cross-national writing research, school writing, curricular analysis, curriculum, assessment tools, national education ; bic Book Industry Communication::J Society & social sciences::JN Education
    Language: English
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    Frontiers Media SA
    Publication Date: 2022-01-31
    Description: This research topic is focused on recent advances in our understanding of effects of mechanical loading on the skeleton, and research methods used in addressing these. Though it is well established that mechanical loading provides an essential stimulus for skeletal growth and maintenance, there have been major advances recently in terms of our understanding of the molecular pathways involved, which are thought to provide novel drug targets for treating osteoporosis. The articles included in this topic encompass the full spectrum of laboratory and clinical research, and range from review articles, editorials, hypothesis papers and original research articles. Together, they demonstrate how mechanical loading underpins many aspects of bone biology, including the pathogenesis and treatment of osteoporosis and other clinical disorders associated with skeletal fragility.
    Keywords: RC648-665 ; R5-920 ; mechanical loading ; bone architecture ; accelerometers ; osteoblast ; osteoporosis ; osteoclast ; fractures ; distraction osteogenesis
    Language: English
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  • 43
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 44
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Thy-1 ; CD90 ; Signal Transduction ; cell-cell interaction ; Cell-matrix interaction ; Scaffold ; Nanodomains ; integrin ; Mechanotransduction ; Cancer ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 45
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: export ; secretion ; pathogens ; toxins ; macromolecular machineries ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MJ Clinical and internal medicine::MJC Diseases and disorders::MJCJ Infectious and contagious diseases
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  • 46
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Heart Rate ; Heart rate variability ; Autonomic Nervous System ; infants ; Children ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 48
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: NMDAR = N-methyl-d-aspartate receptor ; Enzymes - metabolism ; enzyme drug target ; d-serine ; L-serine ; thema EDItEUR::P Mathematics and Science::PD Science: general issues
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  • 49
    Publication Date: 2023-09-12
    Description: The Routledge Handbook of International Human Rights Law provides the definitive global survey of the discipline of international human rights law. Each chapter is written by a leading expert and provides a contemporary overview of a significant area within the field. As well as covering topics integral to the theory and practice of international human rights law the volume offers a broader perspective though examinations of the ways in which human rights law interacts with other legal regimes and other international institutions, and by addressing the current and future challenges facing human rights. Providing up-to-date and authoritative articles covering key aspects of international human rights law, this book work is an essential work of reference for scholars, practitioners and students alike. Chapter 35 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://www.routledgehandbooks.com/doi/10.4324/9780203481417.ch35
    Keywords: books by Nigel Rodley ; counter-terrorism and human rights ; economic, social and cultural rights ; human rights enforcement ; International criminal law and human rights ; International trade and human rights ; international human rights ; international human rights law ; investment and human rights ; Nigel Rodley ; non-State actors and human rights ; UN and human rights ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics
    Language: English
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  • 50
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    Open Book Publishers
    Publication Date: 2022-01-31
    Description: This critical edition of the working notes for Dombey and Son (1848) is ideal for readers who wish to know more about Charles Dickens’s craft and creativity. Drawing on the author’s manuscript in the Victoria and Albert Museum, London—and containing hyperlinked facsimiles—Dickens’s Working Notes for Dombey and Son offers a new digital transcription with a fresh commentary by Tony Laing. Unique and innovative, this is the only edition to make Dickens’s working methods visible. John Mullan has called Dombey and Son Dickens’s 'first great novel.' Set amid the coming of the railways, it tells the story of a powerful man—typical of the commercial and banking magnates of the period—and the effect he has on his family and those around him. Laing presents the worksheets and other materials (transcribed for the first time) that together grew into the novel. Reading the book alongside this edition of the notes enlarges the understanding of Dickens’s art among teachers, students, researchers and Dickens enthusiasts. As cultural tastes shift from print to digital, Dickens’s Working Notes helps preserve Dickens’s work for the future. The magnifying and linking functions of the edition mean that the notes are more easily and usefully—not to mention accessibly—exhibited here than elsewhere. Laing gives present-day readers the chance not only to recapture the effect of serial publication but also to gain greater insight into the making of a work which, by general agreement and Dickens’s own admission, has a special place in his development as a novelist.
    Keywords: PR1-9680 ; worksheets ; transcription ; working notes ; Dombey and Son ; commentary ; critical edition
    Language: English
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  • 51
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    Taylor & Francis | CRC Press
    Publication Date: 2024-04-11
    Description: This book contains selected papers presented at the 4th International Seminar of Contemporary Research on Business and Management (ISCRBM 2020), which was organized by the Alliance of Indonesian Master of Management Program (APMMI) and held in Surubaya, Indonesia, 25-27 November 2020. It was hosted by the Master of Management Program Indonesia University and co-hosts Airlangga University, Sriwijaya University, Trunojoyo University of Madura, and Telkom University, and supported by Telkom Indonesia and Triputra. The seminar aimed to provide a forum for leading scholars, academics, researchers, and practitioners in business and management area to reflect on current issues, challenges and opportunities, and to share the latest innovative research and best practice. This seminar brought together participants to exchange ideas on the future development of management disciplines: human resources, marketing, operations, finance, strategic management and entrepreneurship.
    Keywords: Civil engineering, surveying and building ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building
    Language: English
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    Frontiers Media SA
    Publication Date: 2024-03-30
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: biobank ; samples ; data ; biobank network ; BBMRI
    Language: English
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  • 53
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial ; activity ; extracellular enzyme ; marine ; freshwater ; Metabolic potential ; function ; metabolic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 54
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: precise genome editing ; CRISPR ; HDR efficiency ; biallelic HDR targeting ; off-target effect ; animal model ; base editing ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics
    Language: English
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  • 55
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: "This book offers multidisciplinary perspectives on renewable economies in the Arctic and how these are being supported scientifically, economically, socially, and politically by Arctic states. The economic development of the Arctic region is witnessing new, innovative trends which hold promise for the sustainable development of the region. This book discusses the emerging forms of renewable economies to understand where intellectual and technological innovations are being made. It draws on the expertise of scholars from across the Arctic and provides the reader with a foundation of knowledge to identify the unique challenges of the region and explore opportunities to unlock the immense potential of renewable resources to boost the region’s economy. This book offers a holistic Arctic perspective against the backdrop of prevailing social, economic, and climatic challenges. With critical insights on the economic state of play and the role of renewable resources in the development of the Arctic region, this book will be a vital point of reference for Arctic scholars, communities, and policy makers."
    Keywords: Geography;Human geography ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography
    Language: English
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  • 56
    Publication Date: 2024-04-05
    Description: In this EBook, we highlight how newly emerging techniques for non-invasive manipulation of the human brain, combined with simultaneous recordings of neural activity, contribute to the understanding of brain functions and neural dynamics in humans. A growing body of evidence indicates that the neural dynamics (e.g., oscillations, synchrony) are important in mediating information processing and networking for various functions in the human brain. Most of previous studies on human brain dynamics, however, show correlative relationships between brain functions and patterns of neural dynamics measured by imaging methods such as electroencephalography (EEG), magnetoencephalography (MEG), near-infrared spectroscopy (NIRS), positron emission tomography (PET) and functional magnetic resonance imaging (fMRI). In contrast, manipulative approaches by non-invasive brain stimulation (NIBS) have been developed and extensively used. These approaches include transcranial magnetic stimulation (TMS) and transcranial electric stimulation (tES) such as transcranial direct current stimulation (tDCS), alternating current stimulation (tACS), and random noise stimulation (tRNS), which can directly manipulate neural dynamics in the intact human brain. Although the neural-correlate approach is a strong tool, we think that manipulative approaches have far greater potential to show causal roles of neural dynamics in human brain functions. There have been technical challenges with using manipulative methods together with imaging methods. However, thanks to recent technical developments, it has become possible to use combined methods such as TMS–EEG coregistration. We can now directly measure and manipulate neural dynamics and analyze functional consequences to show causal roles of neural dynamics in various brain functions. Moreover, these combined methods can probe brain excitability, plasticity and cortical networking associated with information processing in the intact human brain. The contributors to this EBook have succeeded in showcasing cutting-edge studies and demonstrate the huge impact of their approaches on many areas in human neuroscience and clinical applications.
    Keywords: RC321-571 ; Q1-390 ; non-invasive brain stimulation NIBS ; TMS-EEG ; Transcranial magnetic stimulation TMS ; transcranial electric stimulation tES ; Coregistration ; Near-infrared spectroscopy NIRS ; Functional magnetic resonance imaging fMRI ; transcranial direct current stimulation tDCS ; transcranial alternating current stimulation tACS ; transcranial random noise stimulation tRNS ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 57
    Publication Date: 2024-04-05
    Description: Bálint’s syndrome is named after the Hungarian physician who first reported a remarkable case of a man with complex visuospatial deficits following bilateral lesions within parietal and occipital cortex (Bálint, 1909). The syndrome has three primary symptoms: simultanagnosia (impaired spatial awareness of more than one object at time), optic ataxia (misreaching to visual targets) and ocular apraxia (described by Bálint as “psychic paralysis of gaze”). Balint’s patients not only cannot perceive more than one object at time and therefore show poor comprehension of multi-object visual scenes i.e. poor detection of all the objects present and difficulty in grasping the relationship between them; in addition they typically fail to reach towards location of the single object, which they can perceive. The deficit of the allocation of spatial attention in Balint’s syndrome has been linked to a problem in feature binding which results in illusory conjunctions. Patients with Balint’s syndrome also show deficits in global processing i.e. when integration of multiple local elements into global compound shapes is required. Consequently, Balint’s syndrome provides a unique opportunity to study the nature and neuroanatomy of human visuospatial processing, in particular multi-level object representation, spatial awareness and the distribution of visual attention. The studies collected here cover both the anatomical and the cognitive mechanisms of the different symptoms associated with the syndrome. Furthermore, the dissociations between the components of Bálints’ syndrome, in particular simultanagnosia and optic ataxia, can also co-occur with visual neglect and extinction and the different combinations of reported lesions raises a question about the status of the syndrome and whether it should be merely treated as a historical compilation of symptoms which may or may not coexist cohesively. This interesting argument is raised here.
    Keywords: RC321-571 ; Q1-390 ; posterior cortical atrophy ; Balints syndrome ; optic ataxia ; Posterior parietal cortex ; simultanagnosia ; ocular apraxia ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 58
    Publication Date: 2024-04-01
    Description: This volume is an investigation of how Augustine was received in the Carolingian period, and the elements of his thought which had an impact on Carolingian ideas of ‘state’, rulership and ethics. It focuses on Alcuin of York and Hincmar of Rheims, authors and political advisers to Charlemagne and to Charles the Bald, respectively. It examines how they used Augustinian political thought and ethics, as manifested in the De civitate Dei, to give more weight to their advice. A comparative approach sheds light on the differences between Charlemagne’s reign and that of his grandson. It scrutinizes Alcuin’s and Hincmar’s discussions of empire, rulership and the moral conduct of political agents during which both drew on the De civitate Dei, although each came away with a different understanding. By means of a philological–historical approach, the book offers a deeper reading and treats the Latin texts as political discourses defined by content and language.
    Keywords: Augustine ; De Civitate Dei ; Rulership ; Alcuin ; Hincmar ; Early medieval Europe ; Carolingian ; Ethics ; Political thought ; Charlemagne ; thema EDItEUR::N History and Archaeology::NH History
    Language: English
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  • 59
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    Springer Nature | Springer
    Publication Date: 2021-02-10
    Description: This open access book provides anthropological insights into the arduous yet rewarding journeys involved in selected TESOL teachers’ pedagogical transition to teaching English for Academic Purposes (EAP) at universities in Shanghai, the largest metropolitan area in China. Applying a unique combination of ethnography and phenomenology, the book offers innovative new perspectives on teacher education research. Drawing on the latest language education theory, it outlines a practitioner-friendly approach to EAP literacy. Teacher readers will especially benefit from the case studies presented here, which provide role models for teacher change in educational reform, as well as advice on their academic careers. In addition to addressing a timely and important research gap on EAP teachers in non-Western countries, the book is the ideal choice for readers interested in an update on English education in China.
    Keywords: Philosophy of Education ; Language Education ; Teaching and Teacher Education ; Social Anthropology ; EAP Teacher Education ; EAP Teaching ; University English Teaching ; China Higher Education ; Teacher Change ; Open Access ; Philosophy & theory of education ; Language: reference & general ; Teacher training ; Social & cultural anthropology ; bic Book Industry Communication::J Society & social sciences::JN Education::JNA Philosophy & theory of education ; bic Book Industry Communication::C Language::CB Language: reference & general ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education::JNMT Teacher training ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography
    Language: English
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  • 60
    Publication Date: 2024-04-14
    Description: Computer science
    Keywords: Computer science ; thema EDItEUR::U Computing and Information Technology::UY Computer science
    Language: English
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  • 61
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World
    Keywords: Ages, Christopher, Contemporary, Everyday, Fletcher, Middle, Objects, Political, World ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
    Language: English
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  • 62
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    Taylor & Francis | Routledge
    Publication Date: 2024-04-02
    Description: This book provides a comparative and transnational examination of the complex and multifaceted experiences of anti-labour mobilisation, from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. It retraces the formation of an extensive market for corporate policing, privately contracted security and yellow unionism, as well as processes of professionalisation in strikebreaking activities, labour espionage and surveillance. It reconstructs the diverse spectrum of right-wing patriotic leagues and vigilante corps which, in support or in competition with law enforcement agencies, sought to counter the dual dangers of industrial militancy and revolutionary situations. Although considerable research has been done on the rise of socialist parties and trade unions the repressive policies of their opponents have been generally left unexamined. This book fills this gap by reconstructing the methods and strategies used by state authorities and employers to counter outbreaks of labour militancy on a global scale. It adopts a long-term chronology that sheds light on the shocks and strains that marked industrial societies during their turbulent transition into mass politics from the bitter social conflicts of the pre-war period, through the epochal tremors of war and revolution, and the violent spasms of the 1920s and 1930s. Offering a new angle of vision to examine the violent transition to mass politics in industrial societies, this is of great interest to scholars of policing, unionism and striking in the modern era.
    Keywords: Armed Associations ; Austria-Hungary ; Czarism ; Dublin Lockout ; Geoff Eley ; Iberian Peninsula ; Industrial vigilantism ; Proto-Fascism ; Russian Empire ; The Dark Side of the Belle Époque ; Tsarism ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 63
    Publication Date: 2024-04-05
    Description: The tale of cyclic GMP has been astonishing. Having overcome an initial disbelief, cyclic GMP has risen to its present eminence as a premium cellular signal transduction messenger of not only hormonal extracellular but also of the intracellular signals. This research topic focuses on the pathways and functions of membrane guanylate cyclases in different tissues of the body and their interplay with intracellular sensory signals where in many cases, cyclic GMP along with Ca2+ have taken on roles as synarchic co-messengers.
    Keywords: RC321-571 ; Q1-390 ; Glaucoma ; Visceral Pain ; Calcium ; membrane guanylate cyclase ; ANF-RGC ; Gene Therapy ; Cyclic GMP ; synaptic plasticity ; trafficking ; ROS-GC ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Microbial communities ; Pollutants ; Environmental risk assessment ; Bioindication ; Biodegradation ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKF Pathology::MKFM Medical microbiology and virology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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    Taylor & Francis
    Publication Date: 2024-03-23
    Description: First published in 1995. Routledge is an imprint of Taylor & Francis, an informa company.
    Keywords: total ; fertility ; rate ; southern ; skilled ; international ; migration ; demographic ; transition ; age ; thema EDItEUR::A The Arts::AM Architecture::AMV Landscape architecture and design::AMVD City and town planning: architectural aspects ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGC Human geography ; thema EDItEUR::A The Arts::AM Architecture::AMV Landscape architecture and design::AMVD City and town planning: architectural aspects ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGC Human geography
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    Taylor & Francis | Changing Paradigms and Approaches in Interpreter Training | Routledge
    Publication Date: 2024-03-24
    Description: The aim of the chapter is to determine whether the current education of interpreters in the Republic of Slovenia responds to the needs of the society. In order to do that, the chapter first briefly outlines the development of the education of Slovene interpreters from its beginnings to the present. By drawing on the results of a nation-wide survey of language-support needs in Slovene healthcare institutions from 2016, which gathered responses of 564 healthcare workers, and on statistics of the Ministry of Interior Affairs of the Republic of Slovenia providing the countries of origin of applicants for international protection in Slovenia in the period between 2013 and 2019, the language needs on the contemporary Slovene society are outlined. These needs are then compared to the results provided by a nation-wide survey of interpreters and sworn interpreters from 2020 (n=123) focusing on language combinations they offer and identifying different settings in which they work. The results of this comparison show that there is a serious mismatch between the needs of the society and the existing language profiles of professional interpreters in the market, which results in the fact that ad-hoc interpreters are used for almost all the languages of newly arrived migrants with negative consequences for society at large. The chapter concludes with the description of educational efforts aimed at remedying the situation: first, a short specialisation program for sworn interpreters introduced in 2018, and second, the education of teachers of community interpreters for Albanian, Arabic and Persian which took place from 2019 to 2020.
    Keywords: Interpreting studies; community interpreting; community interpreter education; interpreting in Slovenia; Slovenia ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Alzheimer's disease ; Neurodegeneration ; Peptides ; cognitive ; model ; Parkinson's disease ; database ; transgenic ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Sport ; performance ; physiology ; kinesiology ; biomechanics ; health ; exercise ; physical activity ; athletes ; training ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::S Sports and Active outdoor recreation ; thema EDItEUR::M Medicine and Nursing::MK Medical specialties, branches of medicine::MKW Sports injuries and medicine
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  • 69
    Publication Date: 2024-04-05
    Description: In the search for simple explanations of the natural world, its complicated textures are often filed down to a smoothened surface of our liking. The impetus for this Research Topic was borne out of a need to re-ignite interest in the complex – in this case in the context of ion channels in the nervous system. Ion channels are the large proteins that form regulated pores in the membranes of cells and, in the brain, are essential for the transfer, processing and storage of information. These pores full of twists and turns themselves are not just barren bridges into cells. More and more we are beginning to understand that ion channels are like bustling medieval bridges (packed with apartments and shops) rather than the more sleek modern variety – they are dynamic hubs connected with many structures facilitating associated activities. Our understanding of these networks continues to expand as our investigative tools advance. Together these articles highlight how the complexity of ion channel signaling nexuses is critical to the proper functioning of the nervous system.
    Keywords: RC321-571 ; Q1-390 ; Nervous System ; Ion Channels ; Interactome ; cellular signaling ; Protein complexes ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 70
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    Frontiers Media SA
    Publication Date: 2024-04-04
    Description: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact
    Keywords: Brainstem monoamine neurons ; locus coeruleus ; emotion ; pain ; morphometry ; amphetamine derivatives ; sleep ; gaze ; trigeminal nerve ; microglia. ; thema EDItEUR::P Mathematics and Science::PD Science: general issues ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 71
    Publication Date: 2024-04-05
    Description: Genome-wide association studies (GWAS) for complex disorders with large case-control populations have been performed on hundreds of traits in more than 1200 published studies (http://www.genome.gov/gwastudies/) but the variants detected by GWAS account for little of the heritability of these traits, leading to an increasing interest in using family based designs. While GWAS studies are designed to find common variants with low to moderate attributable risks, family based studies are expected to find rare variants with high attributable risk. Because family-based designs can better control both genetic and environmental background, this study design is robust to heterogeneity and population stratification. Moreover, in family-based analysis, the background genetic variation can be modeled to control the residual variance which could increase the power to identify disease associated rare variants. Analysis of families can also help us gain knowledge about disease transmission and inheritance patterns. Although a family-based design has the advantage of being robust to false positives, novel and powerful methods to analyze families in genetic epidemiology continue to be needed, especially for the interaction between genetic and environmental factors associated with disease. Moreover, with the rapid development of sequencing technology, advances in approaches to the design and analysis of sequencing data in families are also greatly needed. The 11 articles in this book all introduce new methodology and, using family data, substantial new findings are presented in the areas of infectious diseases, diabetes, eye traits, autism spectrum disorder and prostate cancer.
    Keywords: QH426-470 ; Q1-390 ; Regional heritability ; prostate cancer ; infectious diseases ; MCMC ; combining studies screening ; conditional-logistic linkage ; Informatics ; autism ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
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    Taylor & Francis | Negotiating bioethics | Routledge
    Publication Date: 2024-04-05
    Description: The sequencing of the entire human genome has opened up unprecedented possibilities for healthcare, but also ethical and social dilemmas about how these can be achieved, particularly in developing countries. UNESCO's Bioethics Programme was established to address such issues in 1993. Since then, it has adopted three declarations on human genetics and bioethics (1997, 2003 and 2005), set up numerous training programmes around the world and debated the need for an international convention on human reproductive cloning. Negotiating Bioethics presents Langlois' research on the negotiation and implementation of the three declarations and the human cloning debate, based on fieldwork carried out in Kenya, South Africa, France and the UK, among policy-makers, geneticists, ethicists, civil society representatives and industry professionals. The book examines whether the UNESCO Bioethics Programme is an effective forum for (a) decision-making on bioethics issues and (b) ensuring ethical practice. Considering two different aspects of the UNESCO Bioethics Programme - deliberation and implementation - at international and national levels, Langlois explores: - how relations between developed and developing countries can be made more equal - who should be involved in global level decision-making and how this should proceed - how overlap between initiatives can be avoided - what can be done to improve the implementation of international norms by sovereign states - how far universal norms can be contextualized - what impact the efficacy of national level governance has at international level Drawing on extensive empirical research, Negotiating Bioethics presents a truly global perspective on bioethics
    Keywords: unesco's bioethics programm ; bioethics ; genetics, medical ; program evaluation ; ethics, medical ; international cooperation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bioethics
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  • 73
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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  • 74
    Publication Date: 2022-01-31
    Description: This eBook presents illustrative examples of genetic chaperonopathies affecting primarily nerves and muscles and discusses molecular mechanisms and treatment targeting chaperones, i.e., chaperonotherapy.
    Keywords: Q1-390 ; small-Hsp ; Hsp60/CCT/BBS ; Indirect/Secondary Chaperonopathies ; Genetic Chaperonopathies ; Hsp40/DnaJ ; chaperonotherapy
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  • 75
    Publication Date: 2024-04-01
    Description: This book offers a provocative account of interdisciplinary research across the neurosciences, social sciences and humanities. Setting itself against standard accounts of interdisciplinary 'integration,' and rooting itself in the authors' own experiences, the book establishes a radical agenda for collaboration across these disciplines. Rethinking Interdisciplinarity does not merely advocate interdisciplinary research, but attends to the hitherto tacit pragmatics, affects, power dynamics, and spatial logics in which that research is enfolded. Understanding the complex relationships between brains, minds, and environments requires a delicate, playful and genuinely experimental interdisciplinarity, and this book shows us how it can be done.
    Keywords: neurosciences ; interdisciplinarity ; social sciences ; interdisciplinary research ; integration ; humanities ; Des Fitzgerald ; Epistemology ; Sociology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 76
    Publication Date: 2024-04-05
    Description: Virus-caused asthma, we now call a phenotype of asthma. Regardless of the significance and popularity of this disease, the etiology of the virus-induced asthma have not well understood. In addition, a few effective vaccines have been applied to prevent respiratory virus infection. To solve the issues, it is essential to clarify and delineate both aspects of the virus and host defense systems including acute/chronic inflammation and airway tissue remodeling. To deeply review and discuss pathophysiology and epidemiology of virus-induced asthma, this topics includes new findings of the host immunity, pathology, epidemiology, and virology of asthma/chronic obstructive pulmonary disease (COPD). We believe that these works are well summarized and informative to glimpse the field of virus- associated asthma and COPD, and may help understanding the basic and clinical aspects of the diseases.
    Keywords: QR1-502 ; QK1-989 ; Q1-390 ; virus-induced asthma ; Pathology ; respiratory virus ; human immunity ; Epidemiology ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical)
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  • 77
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    Springer Nature | Springer
    Publication Date: 2024-04-14
    Description: This open access two-volume set constitutes the proceedings of the 26th International Conference on Tools and Algorithms for the Construction and Analysis of Systems, TACAS 2020, which took place in Dublin, Ireland, in April 2020, and was held as Part of the European Joint Conferences on Theory and Practice of Software, ETAPS 2020. The total of 60 regular papers presented in these volumes was carefully reviewed and selected from 155 submissions. The papers are organized in topical sections as follows: Part I: Program verification; SAT and SMT; Timed and Dynamical Systems; Verifying Concurrent Systems; Probabilistic Systems; Model Checking and Reachability; and Timed and Probabilistic Systems. Part II: Bisimulation; Verification and Efficiency; Logic and Proof; Tools and Case Studies; Games and Automata; and SV-COMP 2020.
    Keywords: Software Engineering/Programming and Operating Systems ; Special Purpose and Application-Based Systems ; Computer System Implementation ; Control Structures and Microprogramming ; Mathematics of Computing ; open access ; specification and verification techniques ; software and hardware verification ; SAT and SMT solving ; theorem proving ; model checking ; static and dynamic program analysis ; testing ; system construction and transformation techniques ; tool environments and tool architectures ; abstraction techniques for modeling and verification ; compositional and refinement-based methodologies ; mathematics ; software engineering ; software design ; architecting ; software architecture ; embedded systems ; automata theory ; linguistics ; Software Engineering ; Operating systems ; Expert systems / knowledge-based systems ; Systems analysis & design ; Algorithms & data structures ; Mathematical theory of computation ; Maths for computer scientists ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMZ Software Engineering ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYQ Artificial intelligence::UYQE Expert systems / knowledge-based systems ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYD Systems analysis and design ; thema EDItEUR::U Computing and Information Technology::UM Computer programming / software engineering::UMB Algorithms and data structures ; thema EDItEUR::U Computing and Information Technology::UY Computer science::UYA Mathematical theory of computation
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    Springer Nature | Springer International Publishing
    Publication Date: 2024-04-05
    Description: This Open Access book gives a comprehensive account of both the history and current achievements of molecular beam research. In 1919, Otto Stern launched the revolutionary molecular beam technique. This technique made it possible to send atoms and molecules with well-defined momentum through vacuum and to measure with high accuracy the deflections they underwent when acted upon by transversal forces. These measurements revealed unforeseen quantum properties of nuclei, atoms, and molecules that became the basis for our current understanding of quantum matter. This volume shows that many key areas of modern physics and chemistry owe their beginnings to the seminal molecular beam work of Otto Stern and his school. Written by internationally recognized experts, the contributions in this volume will help experienced researchers and incoming graduate students alike to keep abreast of current developments in molecular beam research as well as to appreciate the history and evolution of this powerful method and the knowledge it reveals.
    Keywords: Quantum Physics ; Atomic/Molecular Structure and Spectra ; Astronomy, Astrophysics and Cosmology ; History and Philosophical Foundations of Physics ; Physics, general ; Atomic and Molecular Structure and Properties ; History of Physics and Astronomy ; Philosophical Foundations of Physics and Astronomy ; Physics and Astronomy ; Open Access ; Molecular Beam History ; Precision Measurements ; Femto- and Atto-science ; Foundations of Quantum Mechanics ; Droplet Beams ; Molecular Beam Applications ; Matter Wave Interferometry ; Ultracold Atoms ; Quantum physics (quantum mechanics & quantum field theory) ; Nuclear physics ; Theoretical & mathematical astronomy ; History of science ; Physics ; thema EDItEUR::P Mathematics and Science::PH Physics::PHQ Quantum physics (quantum mechanics and quantum field theory) ; thema EDItEUR::P Mathematics and Science::PH Physics::PHN Nuclear physics ; thema EDItEUR::P Mathematics and Science::PG Astronomy, space and time ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::P Mathematics and Science::PH Physics
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    Frontiers Media SA
    Publication Date: 2024-04-05
    Description: Transfer cells are anatomically specialized cells optimized to support high levels of nutrient transport in plants. These cells trans-differentiate from existing cell types by developing extensive and localized wall ingrowth labyrinths to amplify plasma membrane surface area which in turn supports high densities of membrane transporters. Unsurprisingly, therefore, transfer cells are found at key anatomical sites for nutrient acquisition, distribution and exchange. Transfer cells are involved in delivery of nutrients between generations and in the development of reproductive organs and also facilitate the exchange of nutrients that characterize symbiotic associations. Transfer cells occur across all taxonomic groups in higher plants and also in algae and fungi. Deposition of wall ingrowth-like structures are also seen in “syncytia” and “giant cells” which function as feeding sites for cyst and root-knot nematodes, respectively, following their infection of roots. Consequently, the formation of highly localized wall ingrowth structures in diverse cell types appears to be an ancient anatomical adaption to facilitate enhanced rates of apoplasmic transport of nutrients in plants. In some systems a role for transfer cells in the formation of an anti-pathogen protective barrier at these symplastic discontinuities has been inferred. Remarkably, the extent of cell wall ingrowth development at a particular site can show high plasticity, suggesting that transfer cell differentiation might be a dynamic process adapted to the transport requirements of each physiological condition. Recent studies exploiting different experimental systems to investigate transfer cell biology have identified signaling pathways inducing transfer cell development and genes/gene networks that define transfer cell identity and/or are involved in building the wall ingrowth labyrinths themselves. Further studies have defined the structure and composition of wall ingrowths in different systems, leading in many instances to the conclusion that this process may involve previously uncharacterized mechanisms for localized wall deposition in plants. Since transfer cells play important roles in plant development and productivity, the latter being relevant to crop yield, especially so in major agricultural species such as wheat, barley, soybean and maize, understanding the molecular and cellular events leading to wall ingrowth deposition holds exciting promise to develop new strategies to improve plant performance, a key imperative in addressing global food security. This Research Topic presents a timely and comprehensive treatise on transfer cell biology to help define critical questions for future research and thereby generating a deeper understanding of these fascinating and important cells in plant biology.
    Keywords: QK1-989 ; Q1-390 ; Wall ingrowth ; Arabidopsis thaliana ; synctial cells ; Zea mays ; transfer cells ; endosperm transfer cells ; Giant Cells ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 81
    Publication Date: 2024-04-05
    Description: Research during the past decade highlights the strong link between appetitive feeding behavior, reward and motivation. Interestingly, stress levels can affect feeding behavior by manipulating hypothalamic circuits and brain dopaminergic reward pathways. Indeed, animals and people will increase or decrease their feeding responses when stressed. In many cases acute stress leads to a decrease in food intake, yet chronic social stressors are associated to increases in caloric intake and adiposity. Interestingly, mood disorders and the treatments used to manage these disorders are also associated with changes in appetite and body weight. These data suggest a strong interaction between the systems that regulate feeding and metabolism and those that regulate mood. This Research Topic aims to illustrate how hormonal mechanisms regulate the nexus between feeding behavior and stress. It focuses on the hormonal regulation of hypothalamic circuits and/or brain dopaminergic systems, as the potential sites controlling the converging pathways between feeding behavior and stress.
    Keywords: RC321-571 ; Q1-390 ; stress ; Obesity ; Dopamine ; Ghrelin ; Leptin ; Seasonal regulation ; feeding ; HPA axis ; Hypothalamus ; circadian rhythms ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 82
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    Springer Nature
    Publication Date: 2024-03-25
    Description: Environmental Economics; Climate Change/Climate Change Impacts; Green Development; Environmental Competitiveness; Environmental Coordination; Economy Transformation; Environmental Carrying; Environmental Management
    Keywords: Environmental Economics ; Climate Change/Climate Change Impacts ; Green Development ; Environmental Competitiveness ; Environmental Coordination ; Economy Transformation ; Environmental Carrying ; Environmental Management ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBC Engineering: general ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WC Antiques, vintage and collectables::WCF Collecting coins, banknotes, medals and other related items
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  • 83
    Publication Date: 2024-04-05
    Description: euromodulation is among the fastest-growing areas of medicine, involving many diverse specialties and affecting hundreds of thousands of patients with numerous disorders worldwide. It can briefly be described as the science of how electrical, chemical, and mechanical interventions can modulate the nervous system function. A prominent example of neuromodulation is deep brain stimulation (DBS), an intervention that reflects a fundamental shift in the understanding of neurological and psychiatric diseases: namely as resulting from a dysfunctional activity pattern in a defined neuronal network that can be normalized by targeted stimulation. The application of DBS has grown remarkably and more than 130,000 patients worldwide have obtained a DBS intervention in the past 30 years—most of them for treating movement disorders. This Frontiers Research Topics provides an overview on the current discussion beyond basic research in DBS and other brain stimulation technologies. Researchers from various disciplines, who are working on broader clinical, ethical and social issues related to DBS and related neuromodulation technologies, have contributed to this research topic.
    Keywords: RC321-571 ; Q1-390 ; Informed Consent ; Deep Brain Stimulation ; Depression ; Neurosurgery ; Movement Disorders ; Neuromodulation ; Enhancement ; Neuroethics ; Philosophy ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 84
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    Taylor & Francis | The Routledge Handbook of Philosophy and Improvisation in the Arts | Routledge
    Publication Date: 2024-04-05
    Description: The idea of improvisation, broadly defined, has been integral to our imagination of the medieval musical past. It can be related to many elements of production: to the act of un-notated creation; to the manipulation and amplification of notated materials; to our observance of rigid rules and formulae; or to spontaneous freedom. Likely a product of the Carolingian Renaissance, this is the first medieval music treatise to address an aspect of chant performance that does not only relate to a memorized repertoire, but includes an unwritten practice of extemporizing an accompanying voice to a pre-given melody. The art of “coloration” or the ornamentation of a line, whether polyphonic or monophonic, had been an integral part of extemporization since at least the time of the Ad organum faciendum treatises. When planning author's ontological inquiries, the author's would do well to remember the possible existence of creativity that is not inspired, or ephemerality that is not performer- or expression-centered.
    Keywords: Philosophy, Ontology, Music, Improvisation, Arts, Performance ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy
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  • 85
    Publication Date: 2024-03-29
    Description: The integration of multisensory information is an essential mechanism in perception and in controlling actions. Research in multisensory integration is concerned with how the information from the different sensory modalities, such as the senses of vision, hearing, smell, taste, touch, and proprioception, are integrated to a coherent representation of objects. Multisensory integration is central for action control. For instance, when you grasp for a rubber duck, you can see its size and hear the sound it produces. Moreover, identical physical properties of an object can be provided by different senses. You can both see and feel the size of the rubber duck. Even when you grasp for the rubber duck with a tool (e.g. with tongs), the information from the hand, from the effect points of the tool and from the eyes are integrated in a manner to act successfully. Over the recent decade a surge of interest in multisensory integration and action control has been witnessed, especially in connection with the idea that multiple sensory sources are integrated in an optimized way. For this perspective to mature, it will be helpful to delve deeper into the information processing mechanisms and their neural correlates, asking about the range and constraints of this mechanisms, about its localization and involved networks.
    Keywords: BF1-990 ; Q1-390 ; recalibration ; haptic ; Human Information Processing ; Vision ; Perception ; reference frame ; Acoustics ; Tool Use ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; thema EDItEUR::J Society and Social Sciences::JM Psychology
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  • 86
    Publication Date: 2024-04-05
    Description: Volume I, entitled “Augmentation of Brain Functions: Brain-Machine Interfaces”, is a collection of articles on neuroprosthetic technologies that utilize brain-machine interfaces (BMIs). BMIs strive to augment the brain by linking neural activity, recorded invasively or noninvasively, to external devices, such as arm prostheses, exoskeletons that enable bipedal walking, means of communication and technologies that augment attention. In addition to many practical applications, BMIs provide useful research tools for basic science. Several articles cover challenges and controversies in this rapidly developing field, such as ways to improve information transfer rate. BMIs can be applied to the awake state of the brain and to the sleep state, as well. BMIs can augment action planning and decision making. Importantly, BMI operations evoke brain plasticity, which can have long-lasting effects. Advanced neural decoding algorithms that utilize optimal feedback controllers are key to the BMI performance. BMI approach can be combined with the other augmentation methods; such systems are called hybrid BMIs. Overall, it appears that BMI will lead to many powerful and practical brain-augmenting technologies in the future.
    Keywords: RC321-571 ; Q1-390 ; microcircuits ; Brain machine interface (BMI) ; nootropics ; tDCStranscranial direct current stimulation ; neural networks ; neuroprosthesis ; TMS ; implants ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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  • 87
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-30
    Description: Ecosystem services; Sustainable development; Environmental management; Natural resource management; Coastal management; Bangladesh and sea-level rise research; Governance of ecosystem services; Regional climate change in South Asia
    Keywords: Ecosystem services ; Sustainable development ; Environmental management ; Natural resource management ; Coastal management ; Bangladesh and sea-level rise research ; Governance of ecosystem services ; Regional climate change in South Asia ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCV Economics of specific sectors::KCVG Environmental economics
    Language: English
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  • 88
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    Taylor & Francis | A Global History of Ideas in the Language of Law | Language and Law | Routledge
    Publication Date: 2024-03-24
    Description: Language plays an essential role both in creating law and in governing its implementation. Providing an accessible and comprehensive introduction to this subject, Language and Law:describes the different registers and genres that make up spoken and written legal language and how they develop over time; analyses real-life examples drawn from court cases from different parts of the world, illustrating the varieties of English used in the courtroom by speakers occupying different roles; addresses the challenges presented to our notions of law and regulation by online communication; discusses the complex role of translation in bilingual and multilingual jurisdictions, including Hong Kong and Canada; and provides readings from key scholars in the discipline, including Lawrence Solan, Peter Goodrich, Marianne Constable, David Mellinkoff, and Chris Heffer. With a wide range of activities throughout, this accessible textbook is essential reading for anyone studying language and law or forensic linguistics.
    Keywords: English for law ; English for specific purposes law ; forensic linguistics ; language and the law ; legal English ; legal genres ; thema EDItEUR::C Language and Linguistics::CB Language: reference and general ; thema EDItEUR::C Language and Linguistics::CF Linguistics ; thema EDItEUR::C Language and Linguistics::CF Linguistics::CFB Sociolinguistics ; thema EDItEUR::L Law::LA Jurisprudence and general issues ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAR Legal aspects of criminology ; thema EDItEUR::L Law::LA Jurisprudence and general issues::LAS Legal skills and practice
    Language: English
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  • 89
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    Taylor & Francis | Routledge
    Publication Date: 2023-09-12
    Description: This book investigates the ways in which soft power is used by African countries to help drive global influence. Selecting four of the countries most associated with soft power across the continent, this book delves into the currencies of soft power across the region: from South Africa’s progressive constitution and expanding multinational corporations, to Nigeria’s Nollywood film industry and Technical Aid Corps (TAC) scheme, Kenya’s sport diplomacy, fashion and tourism industries, and finally Egypt’s Pan-Arabism and its reputation as the cradle of civilisation. The book asks how soft power is wielded by these countries and what constraints and contradictions they encounter. Understandings of soft power have typically been driven by Western scholars, but throughout this book, Oluwaseun Tella aims to Africanise our understanding of soft power, drawing on prominent African philosophies, including Nigeria’s Omolúwàbí, South Africa’s Ubuntu, Kenya’s Harambee, and Egypt’s Pharaonism. This book will be of interest to researchers from across political science, international relations, cultural studies, foreign policy and African Studies.
    Keywords: African Studies ; cultural studies ; foreign policy ; international relations ; political science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies
    Language: English
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  • 90
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    Taylor & Francis
    Publication Date: 2024-03-30
    Description: The Open Access version of this book, available at http://www.tandfebooks.com/doi/view/10.4324/9781315401867, has been made available under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. This book brings together academics, members of European institutions, and regional and national level policymakers in order to assess the performance and direction of EU Cohesion policy against the background of the most significant reforms to the policy in a generation. Responding to past criticisms of the effectiveness of the policy, the policy changes introduced in 2013 have aligned European Structural and Investment Funds with the Europe 2020 strategy and introduced measures to improve strategic coherence, performance and integrated development. EU Cohesion Policy: Reassessing performance and direction argues that policy can only be successfully developed and implemented if there is input from both academics and practitioners. The chapters in the book address four important issues: the effectiveness and impact of Cohesion policy at European, national and regional levels; the contribution of Cohesion policy to the Europe 2020 strategy of smart, sustainable and inclusive growth; the importance of quality of government and administrative capacity for the effective management of the Funds; and the inter-relationships between institutions, territory and place-based policies. The volume will be an invaluable resource to students, academics and policymakers across economics, regional studies, European studies and international relations.
    Keywords: EU ; Cohesion ; Policy ; Economics ; Regional Studies Association ; RSA ; Development ; Policy Makers ; Growth ; Poland ; Latvia ; Diversity ; Smart Specialisation ; Unemployment ; Iain Begg ; David Charles ; Laura Polverari ; Riccardo Crescenzi ; Mara Giua ; Grzegorz Gorzelak ; Jerzy Pieńkowski ; Peter Berkowitz ; Nicola Pontarollo ; Piotr Rosik ; Marcin Stępniak ; Tomasz Komornicki ; Aleksandrs Dahs ; Henning Kroll ; Elizabeth Sanderson ; Peter Wells ; Ian Wilson ; Leaza McSorley ; Jim Campbell ; Jale Tosun ; Stefan Speckesser ; Carsten Jensen ; Jacqueline O'Reilly ; Neculai-Cristian Surubaru ; Mih Fazekas ; IstvJs Tth ; Andrey Demidov ; Gergő Medve-Bnt ; Septimiu-Rares Szabo ; Ugo Fratesi ; Giovanni Perucca ; Liga Baltiņa ; Tatjana Muravska ; IvTosics ; Jacek Zaucha ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCM Development economics and emerging economies ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas::KJMV6 Research and development management ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCM Development economics and emerging economies ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas::KJMV6 Research and development management
    Language: English
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  • 91
    Publication Date: 2023-09-12
    Description: This book brings together researchers from the fields of international human rights law, EU law and constitutional law to reflect on the tug-of-war over the positioning of the centre of gravity of human rights protection in Europe. It addresses both the position of the Convention system vis-à-vis the Contracting States, and its positioning with respect to fundamental rights protection in the European Union. The first part of the book focuses on interactions in this triangle from an institutional and constitutional point of view and reflects on how the key actors are trying to define their relationship with one another in a never-ending process. Having thus set the scene, the second part takes a critical look at the tools that have been developed at European level for navigating these complex relationships, in order to identify whether they are capable of responding effectively to the complexities of emerging realities in the triangular relationship between the EHCR, EU law and national law. Chapter 10 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://s3-us-west-2.amazonaws.com/tandfbis/rt-files/docs/Open+Access+Chapters/9781138121249_oachapter10.pdf
    Keywords: accession ; agreement ; court ; draft ; european ; geir ; judgment ; pilot ; procedure ; ulfstein ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues ; bic Book Industry Communication::L Law::LB International law ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPV Political control & freedoms::JPVH Human rights
    Language: English
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  • 92
    Publication Date: 2024-04-07
    Description: Mathematics Education, Philosophy of Education, Educational Philosophy
    Keywords: Mathematics Education ; Philosophy of Education ; Educational Philosophy ; thema EDItEUR::P Mathematics and Science
    Language: English
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  • 93
    Publication Date: 2024-04-06
    Description: fuzzy arithmetic; defuzzyfication; fuzzy prediction models; analysis; trend processing; uncertainty modeling; propagation of uncertainty; Kosinski’s fuzzy numbers
    Keywords: fuzzy arithmetic ; defuzzyfication ; fuzzy prediction models ; analysis ; trend processing ; uncertainty modeling ; propagation of uncertainty ; Kosinski’s fuzzy numbers ; thema EDItEUR::P Mathematics and Science ; thema EDItEUR::U Computing and Information Technology::UY Computer science
    Language: English
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  • 94
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    Springer Nature
    Publication Date: 2023-03-03
    Description: Cardiology; Pediatrics
    Keywords: Cardiology ; Pediatrics ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBD Medical profession
    Language: English
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  • 95
    Publication Date: 2022-04-28
    Description: Urban Ecology; Urbanism; Sustainable Development; Complex Systems; Science, general; International Environmental Law
    Keywords: Urban Ecology ; Urbanism ; Sustainable Development ; Complex Systems ; Science, general ; International Environmental Law ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJM Management & management techniques::KJMV Management of specific areas ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere ; bic Book Industry Communication::T Technology, engineering, agriculture::TB Technology: general issues::TBX History of engineering & technology ; bic Book Industry Communication::T Technology, engineering, agriculture::TC Biochemical engineering ; bic Book Industry Communication::W Lifestyle, sport & leisure::WC Antiques & collectables::WCF Coins, banknotes, medals, seals (numismatics)
    Language: English
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  • 96
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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  • 97
    Publication Date: 2024-04-05
    Description: Photosystem II is a 700-kDa membrane-protein super-complex responsible for the light-driven splitting of water in oxygenic photosynthesis. The photosystem is comprised of two 350-kDa complexes each made of 20 different polypeptides and over 80 co-factors. While there have been major advances in understanding the mature structure of this photosystem many key protein factors involved in the assembly of the complex do not appear in the holoenzyme. The mechanism for assembling this super-complex is a very active area of research with newly discovered assembly factors and subcomplexes requiring characterization. Additionally the ability to split water is inseparable from light-induced photodamage that arises from radicals and reactive O2 species generated by Photosystem II chemistry. Consequently, to sustain water splitting, a “self repair” cycle has evolved whereby damaged protein is removed and replaced so as to extend the working life of the complex. Understanding how the biogenesis and repair processes are coordinated is among several important questions that remain to be answered. Other questions include: how and when are the inorganic cofactors inserted during the assembly and repair processes and how are the subcomplexes protected from photodamage during assembly? Evidence has also been obtained for Photosystem II biogenesis centers in cyanobacteria but do these also exist in plants? Do the molecular mechanisms associated with Photosystem II assembly shed fresh light on the assembly of other major energy-transducing complexes such as Photosystem I or the cytochrome b6/f complex or indeed other respiratory complexes? The contributions to this Frontiers in Plant Science Research Topic are likely to reveal new details applicable to the assembly of a range of membrane-protein complexes, including aspects of self-assembly and solar energy conversion that may be applied to artificial photosynthetic systems. In addition, a deeper understanding of Photosystem II assembly — particularly in response to changing environmental conditions — will provide new knowledge underpinning photosynthetic yields which may contribute to improved food production and long-term food security.
    Keywords: QK1-989 ; Q1-390 ; Arabidopsis thaliana ; photoactivation ; photosynthesis ; Chlamydomonas reinhardtii ; cyanobacteria ; biogenesis ; Photosystem II ; photodamage ; Nicotiana tabacum ; Synechocystis sp. PCC 6803 ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PST Botany and plant sciences
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  • 98
    Publication Date: 2024-04-05
    Description: Big data is revolutionizing our ability to measure and study the human brain. New technology increases the resolution of images that are being study as well as enables researchers to study the brain as it functions. These technological advances are combined with efforts to collect neuroimaging data on large numbers of subjects, in some cases longitudinally. This combination of advances in measurement and scope of studies requires novel development in the statistical analysis. Fast, scalable, robust and accurate models and approaches need to be developed to make headway on these problems. This volume represents a unique collection of researchers providing deep insights on the statistical analysis of big neuroimaging data.
    Keywords: RC321-571 ; Q1-390 ; fMRI ; Neuroscience ; functional connectivity ; EEG ; Classification ; prediction ; big data ; MEG ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 99
    Publication Date: 2024-04-11
    Description: The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. Manuscripts should yield new insights and ultimately contribute to a safer and more reliable design of building structures and infrastructures. The scope includes the characterization of earthquake ground motions (e.g. near-fault, far-fault, short-period, long-period), their underlying properties, their intrinsic relationship with structural responses, and the true behaviors of building structures and infrastructures under risky and uncertain ground motions. More specific topics include recorded ground motions, generated ground motions, response spectra, stochastic modeling of ground motion, critical excitation, geotechnical aspects, soil mechanics, soil liquefaction, soil-structure interactions, pile foundations, earthquake input energy, structural control, passive control, active control, base-isolation, steel structures, reinforced concrete structures, wood structures, building retrofit, structural optimization, uncertainty analysis, robustness analysis, and redundancy analysis. This eBook includes four original research papers, in addition to the Specialty Grand Challenge article, on the critical earthquake response of elastic-plastic structures under near-fault or long-duration ground motions which were published in the specialty section Earthquake Engineering. In the early stage of dynamic nonlinear response analysis of structures around 1960s, a simple hysteretic structural model and a simple sinusoidal earthquake ground motion input were dealt with together with random inputs. The steady-state response was tackled by an equivalent linearization method developed by Caughey, Iwan and others. In fact, the resonance plays a key role in the earthquake-resistant design and it has a strong effect even in case of near-fault ground motions. In order to draw the steady-state response curve and investigate the resonant property, two kinds of repetition have to be introduced. One is a cycle, for one forced input frequency, of the initial guess of the steady-state response amplitude, the construction of the equivalent linear model, the analysis of the steady-state response amplitude using the equivalent linear model and the update of the equivalent linear model based on the computed steady-state response amplitude. The other is the sweeping over a range of forced input frequencies. This process is quite tedious. Four original research papers included in this eBook propose a new approach to overcome this difficulty. Kojima and Takewaki demonstrated that the elastic-plastic response as continuation of free-vibrations under impulse input can be derived in a closed form by a sophisticated energy approach without solving directly the equations of motion as differential equations. While, as pointed out above, the approach based on the equivalent linearization method requires the repetition of application of the linearized equations, the method by Kojima and Takewaki does not need any repetition. The double impulse, triple impulse and multiple impulses enable us to describe directly the critical timing of impulses (resonant frequency) which is not easy for the sinusoidal and other inputs without a repetitive procedure. It is important to note that, while most of the previous methods employ the equivalent linearization of the structural model with the input unchanged, the method treated in this eBook transforms the input into a series of impulses with the structural model unchanged. This characteristic guarantees high accuracy and reliability even in the large plastic deformation range. The approach presented in this eBook is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic range.
    Keywords: TA1-2040 ; fling-step input ; Critical response ; Long-duration ground motion ; double impulse ; forward-directivity input ; triple impulse ; robustness ; Near-fault ground motion ; Ground motion ; Ductility factor ; uncertainty ; resonance ; Structural parameter ; Earthquake Response ; Elastic-plastic response ; Interval analysis ; Multiple impulse ; Earthquake input energy ; redundancy ; Upper bound of input energy ; earthquake engineering ; critical excitation method ; Energy transfer function ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 100
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    Taylor & Francis
    Publication Date: 2024-04-07
    Description: This fascinating book is the first comprehensive analysis of the economic, social and political interrelationships between tourism and global environmental change: one of the most significant issues facing humankind today. Its contributors argue that the impacts of these changes are potentially extremely serious both for the tourism industry, and for the communities dependent upon it. Integrating knowledge from the social and physical sciences, this significant book explores they key issues surrounding global environmental change, as well as government and industry willingness to meet the challenges posed by it. Divided into four main sections, it investigates: the tourism and global environmental change relationship in specific environments global issues related to environmental change differing perceptions of global environmental change held by tourists and the tourist industry. Comprehensive in scope, topical and integrative, this key text is essential reading for students, scholars and researchers in all aspects of tourism, geography and environmental studies.
    Keywords: climate ; scenario ; industry ; ski ; area ; sustainable ; world ; organization ; sea ; surface ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGC Human geography ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TQ Environmental science, engineering and technology ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WT Travel and holiday::WTH Travel and holiday guides::WTHC Travel guides: eco-tourism / ‘green’ tourism
    Language: English
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