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  • 1
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    The MIT Press | The MIT Press
    Publication Date: 2022-02-21
    Description: Philosophers discuss Jerome Wakefield's influential view of mental disorder as “harmful dysfunction,” with detailed responses from Wakefield himself. One of the most pressing theoretical problems of psychiatry is the definition of mental disorder. Jerome Wakefield's proposal that mental disorder is “harmful dysfunction” has been both influential and widely debated; philosophers have been notably skeptical about it. This volume provides the first book-length collection of responses by philosophers to Wakefield's harmful dysfunction analysis (HDA), offering a survey of philosophical critiques as well as extensive and detailed replies by Wakefield himself. HDA is offered as a definition of mental disorder, but it is also the outcome of a method—conceptual analysis—and contributors first take up HDA's methodology, considering such topics as HDA's influences on the DSM, empirical support for HDA, and clinical practice. They go on to discuss HDA's ultimate goal, the demarcation between normal and abnormal; the dysfunction component of the analysis, addressing issues that include developmental plasticity, autism and neurodiversity, and the science of salience; and the harmful component, examining harmless dysfunction, normal variation, medicalization, and other questions. Wakefield offers substantive responses to each chapter. Contributors Rachel Cooper, Andreas De Block, Steeves Demazeux, Leen De Vreese, Luc Faucher, Denis Forest, Justin Garson, Philip Gerrans, Harold Kincaid, Maël Lemoine, Dominic Murphy, Jonathan Sholl, Tim Thornton, Jerome Wakefield, Peter Zachar
    Keywords: Psychiatry ; disorder ; dysfunction ; harm ; Wakefield ; Diagnostic and Statistical Manual DSM ; function ; Harmful Dysfunction Analysis ; Mental disorder ; Evolution ; DSM ; Critics ; Spitzer ; distress ; disability ; harmful consequence ; dysfunction requirement ; Experimental philosophy ; proper function ; Theories of mental disorder ; theory-neutral ; conceptual analysis ; armchair ; Pluralism ; intuitions ; Clinical practice ; concept of disorder ; Haslam ; constructs ; Attention-Deficit Hyperactivity Disorder ; definition ; psychiatric classification ; Quine ; biological design ; naturally selected disorder ; environment mismatch ; Essentialism ; open concept ; construct validation ; latent variables ; imperfect community ; neo-empiricism ; decline in functioning ; Szasz ; network theory ; Stipulation ; meaning analysis ; abnormality ; Selected-effect ; causal-role ; Boorse ; descriptive ; natural kinds ; Cummins ; intuition ; Mechanistic explanation ; perspectival ; coherence ; Developmental mechanism ; developmental mismatch ; adaptation ; Evolutionary mismatch ; modal mismatch ; depression ; fever ; lactose intolerance ; Neander ; proximal-function ; distal function ; conduct disorder ; developmental disruption ; Low-level mechanisms ; salience system ; dopamine regulation ; aberrant valuation ; delusions ; adaptationism ; cognitive neuroscience ; mechanical-causal analysis ; belief fixation ; syndrome ; Autism ; modules ; ontogeny ; neurodiversity ; Reductionism ; naturalism ; Wittgenstein-Kripke paradox ; normative ; failure ; indeterminacy ; variation ; detrimental consequences ; individual values ; directindirect harm ; clinical significance criter ; bic Book Industry Communication::J Society & social sciences::JM Psychology ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMH Psychiatry
    Language: English
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  • 2
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    Springer Nature | Springer
    Publication Date: 2024-04-05
    Description: This open access book offers the first comprehensive account of the pan-genome concept and its manifold implications. The realization that the genetic repertoire of a biological species always encompasses more than the genome of each individual is one of the earliest examples of big data in biology that opened biology to the unbounded. The study of genetic variation observed within a species challenges existing views and has profound consequences for our understanding of the fundamental mechanisms underpinning bacterial biology and evolution. The underlying rationale extends well beyond the initial prokaryotic focus to all kingdoms of life and evolves into similar concepts for metagenomes, phenomes and epigenomes. The book’s respective chapters address a range of topics, from the serendipitous emergence of the pan-genome concept and its impacts on the fields of microbiology, vaccinology and antimicrobial resistance, to the study of microbial communities, bioinformatic applications and mathematical models that tie in with complex systems and economic theory. Given its scope, the book will appeal to a broad readership interested in population dynamics, evolutionary biology and genomics.
    Keywords: Microbial Genetics and Genomics ; Evolutionary Biology ; Genetics and Population Dynamics ; Microbial Ecology ; Human Genetics ; Genetics and Genomics ; Comparative genomics ; Metagenomics ; Microbial Population Analysis ; Pangenome Profile ; Supra-Genome Analysis ; Adaptive Evolution ; Computational Tools ; Bioinformatic Genomics ; Core Dispensable Genome ; Selection, Recombination, Composition ; Acquired Resistance ; Bacterial Species Concept ; Genomic Diversity ; Bacterial Ecology, Microevolution ; Open Access ; Pan-metagenomics ; Pan-microbiomics ; Pan-epigenome ; Gene Transfer ; Pan-phenomes ; Microbiology (non-medical) ; Genetics (non-medical) ; Evolution ; Applied mathematics ; Ecological science, the Biosphere ; Medical genetics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSG Microbiology (non-medical) ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAJ Evolution ; thema EDItEUR::P Mathematics and Science::PB Mathematics::PBW Applied mathematics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAF Ecological science, the Biosphere ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFN Medical genetics ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAK Genetics (non-medical)
    Language: English
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