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  • bic Book Industry Communication::M Medicine  (987)
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  • 1
    Unknown
    The Great Mindshift : How a New Economic Paradigm and Sustainability Transformations go Hand in Hand (2016)
    Cham : Springer
    Details
    Keywords: Environment ; Industrial management ; Environmental aspects ; Sustainable development ; Environmental economics ; Sociology ; Environment ; Sustainable Development ; Sociology, general ; Environmental Economics ; Sustainability Management
    Description / Table of Contents: 1.Introduction --- 2. What Political Economy adds to Transformation Research --- 3. Why the Mainstream Economic Paradigm Cannot Inform Sustainability Transformations --- 4. Mapping an Emerging New Economic Paradigm in Practice --- 5. How to Work a Great Mindshift for Sustainability Transformations
    Pages: Online-Ressource (XXIII, 184 pages) , 21 illustrations, 14 illustrations in color
    ISBN: 9783319437668
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-43766-8
    Language: English
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  • 2
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    The Great Mindshift : How a New Economic Paradigm and Sustainability Transformations go Hand in Hand (2016)
    Cham : Springer
    Details
    Keywords: Environment ; Industrial management ; Environmental aspects ; Sustainable development ; Environmental economics ; Sociology ; Environment ; Sustainable Development ; Sociology, general ; Environmental Economics ; Sustainability Management
    Description / Table of Contents: 1.Introduction --- 2. What Political Economy adds to Transformation Research --- 3. Why the Mainstream Economic Paradigm Cannot Inform Sustainability Transformations --- 4. Mapping an Emerging New Economic Paradigm in Practice --- 5. How to Work a Great Mindshift for Sustainability Transformations
    Pages: Online-Ressource (XXIII, 184 pages) , 21 illustrations, 14 illustrations in color
    ISBN: 9783319437668
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-319-43766-8
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  • 3
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    Migration, Gender and Social Justice : Perspectives on Human Insecurity (2014)
    Berlin, Heidelberg : Springer
    Details
    Keywords: Social sciences ; Public law ; Human rights ; International humanitarian law ; Anthropology ; Sociology ; Emigration and immigration ; Sex (Psychology) ; Gender expression ; Gender identity ; Social Sciences ; Gender Studies ; Migration ; International Humanitarian Law, Law of Armed Conflict ; Human Rights ; Anthropology ; Public Law
    Description / Table of Contents: Section I: Introduction – migration, gender and social justice: the research and policy agendas --- Section II: Transformation of social reproduction systems and migration: local-global interactions --- Section III: The state and female internal migration: Rights and livelihood security --- Section IV: Complexity of gender: embodiment and intersectionality --- Section V: Liminal legality, citizenship and migrant rights mobilization --- Section VI: Conclusion – the complexities of migration research-policy interactions --- Annex A - Portfolio of Migration Projects, 2006-2009 (21 May 2009) --- Women’s Rights and Citizenship Program --- Annex B - Profile of the Editors
    Pages: Online-Ressource (XII, 408 pages) , 20 illustrations
    ISBN: 9783642280122
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-642-28012-2
    Language: English
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  • 4
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    Networks in the Russian Market Economy (2011)
    London : Palgrave Macmillan
    Details
    Keywords: Marketing ; Public relations ; Computer organization ; International economics ; Economics ; Sociology ; Economics ; International Economics ; Sociology, general ; Computer Systems Organization and Communication Networks ; Marketing ; Economic Systems ; Corporate Communication/Public Relations
    Description / Table of Contents: A PDF version of this book is available for free in open access via the OAPEN Library platform, www.oapen.org. This book examines the significance of networks among the firms operative in the contemporary Russian software industry in the St. Petersburg region
    Pages: Online-Ressource (XI, 184 pages)
    ISBN: 9780230294936
    URL: https://link.springer.com/openurl?genre=book&isbn=978-0-230-29493-6
    Language: English
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  • 5
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    Ester Boserup’s Legacy on Sustainability : Orientations for Contemporary Research (2014)
    Dordrecht : Springer
    Details
    Keywords: Environment ; Agriculture ; Ecosystems ; Sustainable development ; Sociology ; Human geography ; Sex (Psychology) ; Gender expression ; Gender identity ; Environment ; Sustainable Development ; Agriculture ; Gender Studies ; Ecosystems ; Human Geography
    Description / Table of Contents: PART I: Ester Boserup’s Intellectual Heritage --- 1. Ester Boserup: An Interdisciplinary Visionary Relevant for Sustainability --- 2. “Finding Out Is My Life”: Conversations with Ester Boserup in the 1990s --- 3. Boserup’s Theory on Technological Change as a Point of Departure for the Theory of Sociometabolic Regime Transition --- PART II Land Use, Technology and Agriculture --- 4. The Dwindling Role of Population Pressure in Land Use Change – a Case from the South West Pacific --- 5. Conceptual and Empirical Approaches to Mapping and Quantifying Land-Use Intensity --- 6. Malthusian Assumptions, Boserupian Response in Transition to Agriculture Models --- 7. Reconciling Boserup with Malthus: Agrarian Change and Soil Degradation in Olive Orchards in Spain (1750-2000) --- 8. Beyond Boserup: The Role of Working Time in Agricultural Development --- PART III: Population and Gender --- 9. Following Boserup’s Traces: From Invisibility to Informalisation of Women’s Economy to Engendering Development in Translocal Spaces --- 10. Daughters of the Hills: Gendered Agricultural Production, Modernisation, and Declining Child Sex Ratios in the Indian Central Himalayas --- 11. Revisiting Boserup’s Hypotheses in the Context of Africa --- 12. An Interpretation of Large-Scale Land Deals Using Boserup’s Theories of Agricultural Intensification, Gender and Rural Development --- 13. Labour Migration and Gendered Agricultural Asset Shifts in Southeastern Mexico: Two Stories of Farming Wives and Daughters --- 14. Working Time of Farm Women and Small-Scale Sustainable Farming in Austria --- 15. A Human Ecological Approach to Ester Boserup: Steps Towards Engendering Agriculture and Rural Development --- 16. Conclusions: Re-Evaluating Boserup in the Light of the Contributions to this Volume
    Pages: Online-Ressource (XXV, 267 pages) , 44 illustrations, 22 illustrations in color
    ISBN: 9789401786782
    URL: https://link.springer.com/openurl?genre=book&isbn=978-94-017-8678-2
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  • 6
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    Ester Boserup’s Legacy on Sustainability : Orientations for Contemporary Research (2014)
    Dordrecht : Springer
    Details
    Keywords: Environment ; Agriculture ; Ecosystems ; Sustainable development ; Sociology ; Human geography ; Sex (Psychology) ; Gender expression ; Gender identity ; Environment ; Sustainable Development ; Agriculture ; Gender Studies ; Ecosystems ; Human Geography
    Description / Table of Contents: PART I: Ester Boserup’s Intellectual Heritage --- 1. Ester Boserup: An Interdisciplinary Visionary Relevant for Sustainability --- 2. “Finding Out Is My Life”: Conversations with Ester Boserup in the 1990s --- 3. Boserup’s Theory on Technological Change as a Point of Departure for the Theory of Sociometabolic Regime Transition --- PART II Land Use, Technology and Agriculture --- 4. The Dwindling Role of Population Pressure in Land Use Change – a Case from the South West Pacific --- 5. Conceptual and Empirical Approaches to Mapping and Quantifying Land-Use Intensity --- 6. Malthusian Assumptions, Boserupian Response in Transition to Agriculture Models --- 7. Reconciling Boserup with Malthus: Agrarian Change and Soil Degradation in Olive Orchards in Spain (1750-2000) --- 8. Beyond Boserup: The Role of Working Time in Agricultural Development --- PART III: Population and Gender --- 9. Following Boserup’s Traces: From Invisibility to Informalisation of Women’s Economy to Engendering Development in Translocal Spaces --- 10. Daughters of the Hills: Gendered Agricultural Production, Modernisation, and Declining Child Sex Ratios in the Indian Central Himalayas --- 11. Revisiting Boserup’s Hypotheses in the Context of Africa --- 12. An Interpretation of Large-Scale Land Deals Using Boserup’s Theories of Agricultural Intensification, Gender and Rural Development --- 13. Labour Migration and Gendered Agricultural Asset Shifts in Southeastern Mexico: Two Stories of Farming Wives and Daughters --- 14. Working Time of Farm Women and Small-Scale Sustainable Farming in Austria --- 15. A Human Ecological Approach to Ester Boserup: Steps Towards Engendering Agriculture and Rural Development --- 16. Conclusions: Re-Evaluating Boserup in the Light of the Contributions to this Volume
    Pages: Online-Ressource (XXV, 267 pages) , 44 illustrations, 22 illustrations in color
    ISBN: 9789401786782
    URL: https://link.springer.com/openurl?genre=book&isbn=978-94-017-8678-2
    Language: English
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  • 7
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    Migration, Gender and Social Justice : Perspectives on Human Insecurity (2014)
    Berlin, Heidelberg : Springer
    Details
    Keywords: Social sciences ; Public law ; Human rights ; International humanitarian law ; Anthropology ; Sociology ; Emigration and immigration ; Sex (Psychology) ; Gender expression ; Gender identity ; Social Sciences ; Gender Studies ; Migration ; International Humanitarian Law, Law of Armed Conflict ; Human Rights ; Anthropology ; Public Law
    Description / Table of Contents: Section I: Introduction – migration, gender and social justice: the research and policy agendas --- Section II: Transformation of social reproduction systems and migration: local-global interactions --- Section III: The state and female internal migration: Rights and livelihood security --- Section IV: Complexity of gender: embodiment and intersectionality --- Section V: Liminal legality, citizenship and migrant rights mobilization --- Section VI: Conclusion – the complexities of migration research-policy interactions --- Annex A - Portfolio of Migration Projects, 2006-2009 (21 May 2009) --- Women’s Rights and Citizenship Program --- Annex B - Profile of the Editors
    Pages: Online-Ressource (XII, 408 pages) , 20 illustrations
    ISBN: 9783642280122
    URL: https://link.springer.com/openurl?genre=book&isbn=978-3-642-28012-2
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  • 8
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    Electrospun and Electrosprayed Formulations for Drug Delivery (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This book is comprised of important reviews and cutting-edge original research papers concerning electrospun and electrosprayed formulations in drug delivery. Electrospinning and electrospraying have, in recent years, attracted increasing attention in the pharmaceutical sector, with research in the area advancing rapidly. It is now possible to prepare extremely complex systems using multi-fluid processes, and to increase production rates to an industrial scale. Electrospun formulations can be produced under GMP conditions and are in clinical trials. In this volume, we explore a range of topics around electrospinning and electrospraying in controlled drug delivery. Four reviews cover the exciting potential of cyclodextrin-containing fibers and the many potential biomedical applications of electrospun fibers. The use of electrospinning to prepare amorphous systems and improve the dissolution rate and solubility of poorly soluble active ingredients is addressed, and the possibilities of such materials in tissue engineering are comprehensively covered. The six original research papers cover the effect of molecular properties on API release from Eudragit-based electrospun fibers; ferulic acid solid dispersions; electrospun medicines to treat psoriasis; scale up of electrospinning and its use to produce low-dose tablets; transepithelial permeation of drugs released from electrospun fibers, and the possibilities for the synergistic chemophotothermal treatment of cancer.
    Keywords: R5-920 ; RM1-950 ; tissue engineering ; cyclodextrin ; permeability ; poly (vinylpyrrolidone-co-vinyl acetate) ; crystalline ; antibacterial ; drug delivery ; homogenization ; capsaicin ; combination therapy ; high-shear mixing ; cyclodextrin-inclusion complexes ; amorphous ; high-speed electrospinning ; PMVE/MA ; aqueous solubility enhancement ; sieve analysis ; Raman mapping ; Eudragit ; nanofibers ; psoriasis ; PCL ; essential oils ; parameters ; antibiotics ; xanthan gum ; carvedilol ; amorphous composite ; coaxial electrospinning ; insoluble drug ; NIR-triggered drug release ; fast dissolution ; electrospinning ; oral drug delivery ; electrospun nanofibers ; poly-cyclodextrin ; TRPV1 ; gallic acid ; solid dispersion ; photothermal therapy ; drug release ; applications ; bic Book Industry Communication::M Medicine
    Language: English
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  • 9
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    Beverage Consumption Habits around the World: Association with Total Water and Energy Intakes (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Fluid intake has barely been assessed, and hydration status has only rarely been measured in epidemiological studies. This hampers attempts to assess the adequacy of water intake at a population level. However, although guidelines have been established to determine how much water humans require to avoid dehydration and to optimize physical and psychological function, limited data are available on the total water and beverages intake. Therefore, the percentage of population with inadequate water intake is unknown. There is a clear need for studies in different settings around the world that quantify total water and beverage intake and explore associations between types of beverages consumed and energy intake.
    Keywords: R5-920 ; Adequate hydration ; Beverages consumption ; Water and energy intake ; bic Book Industry Communication::M Medicine
    Language: English
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  • 10
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    Neuroimmune Interface in Health and Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
    Language: English
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  • 11
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    Equality and Diversity (2021)
    Policy Press
    Details
    Publication Date: 2024-04-04
    Description: This important book explores the values of equality and diversity as promoted across liberal societies, drawing on various traditions of political and social philosophy, and applying them to policy and practice debates.
    Keywords: Sociology ; Diversity ; Equality ; Incommensurability ; Politics ; Recognition ; Value ; Disability ; Egalitarianism ; Empathy ; Existentialism ; Friedrich Nietzsche ; Immanuel Kant ; John Rawls ; Liberalism ; Modern liberalism in the United States ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFA Social discrimination and social justice
    Language: English
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  • 12
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    Inhibiting PARP as a Strategic Target in Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Poly-ADP ribose polymerase (PARP) proteins are critical mediators of DNA repair. Many traditional anti-cancer chemotherapy agents overwhelm a cell’s ability to repair DNA damage in order to kill proliferating malignant cells. Recent evidence suggests that cancers within and across tissue types have specific defects in DNA repair pathways, and that these defects may predispose for sensitivity and resistance to various classes of cytotoxic agents. Breast, ovarian and other cancers develop in the setting of inherited DNA repair deficiency, and these cancers may be more sensitive to cytotoxic agents that induce DNA strand breaks, as well as to inhibitors of PARP activity. A series of recent clinical trials has tested whether PARP inhibitors can achieve synthetic lethality in hereditary DNA repair-deficient tumors. At the current time, mutation of BRCA serves as a potential, but not comprehensive, biomarker to predict response to PARP inhibitor therapy. Mechanisms of resistance to PARP inhibitors are only recently being uncovered. Future studies seek to identify sporadic cancers that harbor genomic instability rendering susceptibility to PARP inhibitors that compound lethal DNA damage.
    Keywords: R5-920 ; RC254-282 ; DNA reapir ; PARP inhibitor ; Homologous Recombination ; combination therapy ; DNA Damage ; Cancer ; bic Book Industry Communication::M Medicine
    Language: English
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  • 13
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    International Perspectives on Health and Safety Among Dairy Workers Challenges, Solutions and the Future (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: This e-book provides the insight into occupational health and safety problems, challenges and solutions of the dairy sector. Thirty-two authors have been sharing their results and knowledge reflecting the challenges from small scale farming up to industrial style. The worldwide trend of growing farm sizes and a reduction in numbers is one of the major drivers for the changes in the working environment. Musculoskeletal disorders are among the most prevalent health problems of people working on farms. Nevertheless mechanisation has not reduced the number of complaints, and new problems arise due to the changing working environment.
    Keywords: R5-920 ; RA1-1270 ; immigrant workers ; Dairy farming ; OHS ; MSS ; MSD ; bic Book Industry Communication::M Medicine
    Language: English
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  • 14
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    From Ptolemaus to Copernicus: The Evolving System of Gluten-Related Disorder (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Gluten is the major protein of wheat and other cereals (rye and barley); it is responsible for triggering celiac disease (CD) in genetically predisposed individuals. Until a few years ago, CD was the major (if not the only) well-known gluten-related disorder. However, in recent years, it has become clear that gluten proteins may activate different pathological mechanisms, leading to a wide spectrum of human diseases, including non-celiac gluten sensitivity (NCGS), gluten ataxia, neuro-psychiatric disorders, and many others. Conceptually, we have therefore moved from a Ptolemaic to a Copernican system, i.e., CD is no longer the “center of the universe”, but is just one of the possible worlds of gluten intolerance. Many other gluten planets do indeed exist and deserve the attention of researchers and clinicians alike. Although different gluten-related disorders show specific epidemiological, pathophysiological, and clinical aspects, these conditions share a trigger and treatment: the gluten-free diet. For a very long time, awareness of these disorders has been limited and, therefore, the epidemiology of gluten-related disorders is still a “work in progress”. Current research strives to clarify the boundaries between these entities, their disease mechanisms, and how a proper diagnosis can be implemented.
    Keywords: R5-920 ; gluten-related disorders；celiac disease；gluten intolerance ; bic Book Industry Communication::M Medicine
    Language: English
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  • 15
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    Inventing America's First Immigration Crisis (2023)
    Fordham University Press
    Details
    Publication Date: 2023-10-05
    Description: Why have Americans expressed concern about immigration at some times but not at others? In pursuit of an answer, this book examines America's first nativist movement, which responded to the rapid influx of 4.2 million immigrants between 1840 and 1860 and culminated in the dramatic rise of the National American Party. As previous studies have focused on the coasts, historians have not yet completely explained why westerners joined the ranks of the National American, or "Know Nothing," Party or why the nation's bloodiest anti-immigrant riots erupted in western cities-namely Chicago, Cincinnati, Louisville, and St. Louis. In focusing on the antebellum West, Inventing America's First Immigration Crisis illuminates the cultural, economic, and political issues that originally motivated American nativism and explains how it ultimately shaped the political relationship between church and state. In six detailed chapters, Ritter explains how unprecedented immigration from Europe and rapid westward expansion reignited fears of Catholicism as a corrosive force. He presents new research on the inner sanctums of the secretive Order of Know-Nothings and provides original data on immigration, crime, and poverty in the urban West. Ritter argues that the country's first bout of political nativism actually renewed Americans' commitment to church-state separation. Native-born Americans compelled Catholics and immigrants, who might have otherwise shared an affinity for monarchism, to accept American-style democracy. Catholics and immigrants forced Americans to adopt a more inclusive definition of religious freedom. This study offers valuable insight into the history of nativism in U.S. politics and sheds light on present-day concerns about immigration, particularly the role of anti-Islamic appeals in recent elections.
    Keywords: Sociology ; History ; American Studies ; Religion ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFJ Social discrimination & inequality ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJK History of the Americas ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRC Christianity::HRCC Christian Churches & denominations::HRCC7 Roman Catholicism, Roman Catholic Church
    Language: English
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  • 16
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    Microglia in Health and Disease: A Unique Immune Cell Population (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
    Language: English
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  • 17
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    HLA-G-mediated Immune Tolerance: Past and New Outlooks (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 18
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    Aging and Self-Realization (2021)
    transcript Verlag
    Details
    Publication Date: 2022-05-02
    Description: Dominant cultural narratives about later life dismiss the value senior citizens hold for society. In her cultural-philosophical critique, Hanne Laceulle outlines counter narratives that acknowledge both potentials and vulnerabilities of later life. She draws on the rich philosophical tradition of thought about self-realization and explores the significance of ethical concepts essential to the process of growing old such as autonomy, authenticity and virtue. These counter narratives aim to support older individuals in their search for a meaningful age identity, while they make society recognize its senior members as valued participants and moral agents of their own lives.
    Keywords: Sociology ; Memory ; Ageing ; Cultural Practices ; Media ; Collective Memory ; Narrative ; Reminiscence ; Representation ; Lifespan ; Biopics ; Music By The Elderly ; Artefacts ; Aging Studies ; Memory Culture ; Cultural Studies ; Self-Realization ; Cultural Narratives ; Autonomy ; Virtue ; Aging Studies ; Culture ; Philosophy of Culture ; Cultural Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSP Age groups::JFSP3 Age groups: adults::JFSP31 Age groups: the elderly
    Language: English
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  • 19
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    Collective Decision Making in Rural Japan (2021)
    University of Michigan Press | U of M Center For Japanese Studies
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    Publication Date: 2024-03-29
    Description: Society and social sciences;Sociology;Veterinary medicine: infectious diseases and therapeutics
    Keywords: Society and social sciences ; Sociology ; Veterinary medicine: infectious diseases and therapeutics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
    Language: English
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  • 20
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    Current Trends and Future Directions in Prosthetic and Implant Dentistry in the Digital Era (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-01-05
    Description: Advancements in digital technologies are reshaping the world of dentistry, from prosthodontics to implant dentistry. Intraoral scanners, facial scanners, 3D printers, and milling machines have revolutionized the clinical approach and operative workflow in daily practice. However, digital dentistry brings several challenges to clinicians due to the rapid evolution of new technologies and the lack of evidence-based guidelines for their correct use. The aim of this Special Issue is to cover the latest advances in the development and application of digital technologies in prosthetic and implant dentistry. We wish to provide both clinicians and researchers with a comprehensive and up-to-date source of information on current trends, limitations, and potential future applications of digital technologies in daily clinical practice.
    Keywords: dental implants ; digital impression ; intraoral scanner ; CAD/CAM materials ; toothbrushing wear ; surface ; roughness ; surface integrity ; alveolar remodeling ; tooth extraction ; intraoral digital scanning ; imaging superimposition ; less traumatic surgery ; socket healing ; implantology ; computer-aided surgery ; image-guided surgery ; zygomatic implants ; navigation system ; dental implant ; bone level ; prospective study ; sub-crestal placement ; emergence profile ; guided surgery ; digital workflow ; stereolithographic surgical guide ; accuracy ; CAD–CAM ; DICOM–STL ; static guided surgery ; clinical study ; intraoral scanners ; digital dentistry ; impression techniques ; full-arch impression ; elderly population ; dimensional measurement accuracy ; implant scan ; operator ; precision ; scan area ; trueness ; occlusion ; overloading ; complications ; implant-supported restorations ; marginal bone loss ; oral implantology ; intraoral scan ; cone-beam computed tomography ; oral surgery ; emergence angle ; retrospective study ; bic Book Industry Communication::M Medicine
    Language: English
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    Migration and Social Protection in Europe and Beyond (Volume 3) (2021)
    Springer Nature | Springer International Publishing
    Details
    Publication Date: 2021-02-10
    Description: This third and last open access volume in the series takes the perspective of non-EU countries on immigrant social protection. By focusing on 12 of the largest sending countries to the EU, the book tackles the issue of the multiple areas of sending state intervention towards migrant populations. Two “mirroring” chapters are dedicated to each of the 12 non-EU states analysed (Argentina, China, Ecuador, India, Lebanon, Morocco, Russia, Senegal, Serbia, Switzerland, Tunisia, Turkey). One chapter focuses on access to social benefits across five core policy areas (health care, unemployment, old-age pensions, family benefits, guaranteed minimum resources) by discussing the social protection policies that non-EU countries offer to national residents, non-national residents, and non-resident nationals. The second chapter examines the role of key actors (consulates, diaspora institutions and home country ministries and agencies) through which non-EU sending countries respond to the needs of nationals abroad. The volume additionally includes two chapters focusing on the peculiar case of the United Kingdom after the Brexit referendum. Overall, this volume contributes to ongoing debates on migration and the welfare state in Europe by showing how non-EU sending states continue to play a role in third country nationals’ ability to deal with social risks. As such this book is a valuable read to researchers, policy makers, government employees and NGO’s.
    Keywords: Social Sciences, general ; Microeconomics ; Social Policy ; Sociology of Migration ; Open access ; Non-EU countries ; Immigrant social protection ; Migrant populations ; Argentina, China, Ecuador, India ; Lebanon, Morocco, Russia ; Senegal, Serbia, Switzerland ; Tunisia, Turkey ; Health care ; Unemployment ; Old-age pensions ; Guaranteed minimum resources ; Family benefits ; Migration and integration ; Sending states ; Society & Social Sciences ; Sociology ; Political economy ; Social & ethical issues ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCC Microeconomics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy
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    COVID-19: Current Status and Future Prospects (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: On 11 March 2020, the World Health Organization declared COVID-19 a global pandemic, and the disease now affects nearly every country and region. Nearly 18 months later, COVID-19, caused by SARS-CoV-2, continues to present significant challenges to health systems, public health, and the economy of countries across both hemispheres. The morbidity and mortality of the infection caused by SARS-CoV-2 has been significant, and various waves of disease outbreaks initially overwhelmed hospitals and clinics in many countries and continue to do so. This influences everyone, and public health countermeasures have been dramatic in terms of their impact on employment, social systems, and mental health. This Special Issue collection follows on from the Special Issue “COVID-19: Current Challenges and Future Perspectives” and provides an avenue for authors from various disciplines to provide feedback on the response to and our future global preparedness for COVID-19, as well as to disseminate critical information about SARS-CoV-2 and the associated COVID-19 pandemic.
    Keywords: COVID-19 ; new-onset DM ; severe infection ; mortality ; outbreak ; P.1 variant ; Gamma variant ; SARS-CoV-2 infection ; whole-genome sequencing ; pandemic ; overweight ; obesity ; Peru ; psychological impacts ; public health ; preparedness ; mRNA-1273 ; BNT162b2 ; TAK-919 ; SARS-CoV-2 ; post-vaccination ; healthcare personnel ; vaccination ; asymptomatic infection ; HIV ; infectious disease ; excess mortality ; regdanvimab ; remdesivir ; severe ; community transmission ; population density gradient ; Dhaka ; Bangladesh ; dengue ; undifferentiated febrile illness ; antigen testing ; variants ; reinfections ; breakthrough infections ; vaccine hesitancy ; sub-Saharan Africa ; pulmonary fibrosis ; postacute COVID-19 syndrome ; tuberculosis ; helminth coinfection ; coronavirus ; coordination ; health operations and technical expertise ; AFRO ; diarrhea ; liver ; pancreas ; inflammatory bowel diseases ; liver transplantation ; reproduction rate ; phylogenetic analysis ; clade GK ; D614G ; P681R ; cross-reactivity ; haemorrhage ; thrombocytopenia ; thrombosis ; severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) ; molecular diagnostics ; real-time polymerase chain reaction (RT-qPCR) ; economy ; income levels ; waves ; policy ; turning points ; occupational exposure ; risk factors ; personal protective equipment ; SIR model ; socio-behavioral aspects ; interaction distance ; school reopening strategy ; self-medication ; over-the-counter ; medicine use ; Pakistan ; clinical features ; Luanda ; Angola ; socioeconomic status ; risk perception ; risk prevention practices ; qualitative ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Capacity Building at the Kurdistan Region Statistics Office Through Data Collection (2023)
    RAND Corporation
    Details
    Publication Date: 2024-04-02
    Description: The Kurdistan Region of Iraq needs policy-relevant data to help improve infrastructure, encourage the private sector, attract foreign investment, and foster economic growth. The Kurdistan Region Statistics Office needs to build capacity to collect the data. RAND worked closely with the Office to build capacity by preparing, conducting, and analyzing the first round of a survey of the regional labor force.
    Keywords: History ; Sociology ; Law ; thema EDItEUR::N History and Archaeology::NH History::NHG Middle Eastern history ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNH Employment and labour law: general ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBC Social research and statistics
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    Pathogenesis and Targeted Therapy of Epilepsy (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Epilepsy is one of the most prevalent neurological disorders and is characterized by recurrent seizures resulting from abnormal neuronal excitability in the central nervous system. Despite the availability of thirty-six antiseizure medications, about one-third of patients with epilepsy do not respond to the pharmacological treatment and develop a so-called “pharmaco-resistant epilepsy” or “refractory epilepsy.” Thus, there is an urgent need to develop novel, effective therapies based on novel mechanisms underlying neuronal excitability that leads to seizures. This reprint’s original research papers and review articles highlight unknown mechanisms underlying pharmaco-resistant resistant epilepsy, epileptogenesis, and seizure suppression.
    Keywords: 3CAI ; GRIA1 ; GRIA2 ; intractable epilepsy ; PICK1 ; protein kinase C ; pericytes ; mural cells ; cytokine ; blood-brain barrier ; neuroinflammation ; 3-phosphoinositide-dependent protein kinase-1 ; AKT ; cyclosporin A ; GluA1 ; GluR1 ; PDK1 ; refractory seizure ; temporal lobe epilepsy ; hippocampus ; 4-aminopyridine ; epilepsy model ; long-term potentiation ; AMPA receptor ; audiogenic epilepsy ; rodents ; fear reaction ; behavior genetics ; c-Fos ; early gene activation ; epileptogenesis ; lipopolysaccharide ; pentylenetetrazole ; post-traumatic epilepsy ; seizure susceptibility ; traumatic brain injury ; epilepsy ; ghrelin ; ghrelin receptor ; anxiety ; TRPV1 channels ; neuronal activity ; neuropsychiatric comorbidity ; immunofluorescence ; audiogenic kindling ; acoustically evoked seizures ; EACT ; generalized tonic-clonic seizures ; inherited epilepsy ; TMEM1A channels ; wild running seizures ; astrocyte ; ML365 ; pharmacoresistant epilepsy ; cortical atrophy ; hippocampal atrophy ; intracerebral electrode ; magnetic resonance imaging ; posttraumatic epilepsy ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
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    Cross Talk between Lymph Node Lymphatic Endothelial Cells and T Cells in Inflammation and Cancer (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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    Transmucosal Absorption Enhancers in the Drug Delivery Field (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Development of strategies to assist the movement of poorly permeable molecules across biological barriers has long been the goal of drug delivery science. In the last three decades, there has been an exponential increase in advanced drug delivery systems that aim to address this issue. However, most proprietary delivery technologies that have progressed to clinical development are based on permeation enhancers (PEs) that have a history of safe use in man. This Special Issue entitled “Transmucosal Absorption Enhancers in the Drug Delivery Field” aims to present the current state-of-the-art in the application of PEs to improve drug absorption. Emphasis is placed on identification of novel permeation enhancers, mechanisms of barrier alteration, physicochemical properties of PEs that contribute to optimal enhancement action, new delivery models to assess PEs, studies assessing safety of PEs, approaches to assist translation of PEs into effective oral, nasal, ocular and vaginal dosage forms and combining PEs with other delivery strategies.
    Keywords: R5-920 ; RM1-950 ; chitosan ; intestinal epithelial cells ; ocular delivery ; amphiphilic polymers ; cornea ; tight junction modulator ; cyclodextrin ; permeability ; gemini surfactant ; transferrin ; compound 48/80 ; epithelial permeability ; cervicovaginal tumors ; nanoparticles ; confocal laser scanning microscopy ; safety ; formulation ; salcaprozate sodium ; intestinal absorption ; FITC-dextran ; curcumin ; block copolymers ; nasal vaccination ; whole leaf ; brush border ; ocular drug delivery ; vaccine adjuvant ; nanoparticle ; nasal delivery ; efflux ; permeation enhancers ; absorption enhancers ; nose to brain delivery ; small intestine ; epithelium ; CNS disorders ; absorption modifying excipients ; insulin ; absorption enhancer ; gel ; intestinal delivery ; thermogel system ; Caco-2 ; biocompatibility studies ; absorption enhancement ; man ; PN159 ; poorly absorbed drug ; tryptophan ; tight junction ; oral macromolecule delivery ; penetration enhancer ; intestinal permeation enhancers ; nanocrystals ; simvastatin ; nanomedicine ; enterocyte ; N-dodecyl-?-D-maltoside (DDM) ; cell-penetrating peptide ; quaternization ; KLAL ; nasal ; nasal permeability ; transmucosal drug delivery ; Caco-2 cells ; mast cell activator ; penetration enhancers ; drug delivery ; nose-to-brain ; bioenhancer ; polymeric micelles ; mucoadhesion ; cell-penetrating peptide (CPP) ; simulated intestinal fluid ; vaginal delivery ; nasal formulation ; pharmacokinetic interaction ; sodium caprate ; clinical trial ; transmucosal permeation ; drug absorption enhancer ; sugar-based surfactants ; nanocapsules ; imatinib ; teriparatide ; osteoporosis ; hydrophobization ; F-actin ; combined microsphere ; transepithelial electrical resistance ; oral delivery ; ocular conditions ; metabolism ; antimicrobial peptide ; permeation enhancer ; drug administration ; antiepileptic drug ; amino acid ; in vivo studies ; sodium cholate (NaC) ; epithelial transport ; preclinical ; nose to brain transport ; pharmacokinetics ; chitosan derivatives ; ophthalmology ; tight junctions ; sheep ; cationic functionalization ; GLP-1 ; pulmonary ; and liposome ; cytochrome P450 ; claudin ; P-glycoprotein ; in situ hydrogel ; mucoadhesiveness ; PTH 1-34 ; Aloe vera ; oral peptides ; bic Book Industry Communication::M Medicine
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    Farmers in the Forest (2023)
    University of Hawai'i Press
    Details
    Publication Date: 2023-10-05
    Description: Farmers in the Forest, while using examples chiefly from northern Thailand, is concerned with complex problems found in all tropical countries. In these areas rapid population growth, increasing demands for food, and burgeoning international markets for forest products and other raw materials are associated with active competition for land and natural resources in upland areas. This book brings together studies by administrators, agronomists, anthropologists, forest ecologists, geographers and jurists, who describe a variety of swidden systems and their effect on soil, forest, society, and economy. They point to conflicts between traditional farming systems and modern legal and administrative constraints now being imposed, and they describe special and technological conditions that contribute to a marginal, stagnant upland economy, increasing socio-economic disparities with the lowlands, and the serious ecological consequences of these conditions. Several possible solutions are suggested to solve these problems.
    Keywords: Sociology ; Anthropology ; Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies::JFCV Food & society
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    A Continent Moving West? (2023)
    Amsterdam University Press
    Details
    Publication Date: 2024-03-29
    Description: A Continent Moving West? argues that the conceptualization of migration as a one-way or long-term process is becoming increasingly wide of the mark. Rather, east-west labor migration in Europe, in common perhaps with other flows in and from other parts of the world, is diverse, fluid, and influenced by the dynamics of local and sector-specific labor markets and migration-related political regulations. The papers in this book contribute to critical understanding of the east-west migration within the European Union after the 2004 enlargement, from the new to the old member states.
    Keywords: Sociology ; Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
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    From War to the Rule of Law (2023)
    Amsterdam University Press
    Details
    Publication Date: 2024-03-29
    Description: As recent events in Iraq demonstrate, countries that have suffered civil war or rule by military regime can face a long, difficult transition to peaceful democracy. Drawing on the experiences of Bosnia, Haiti, Rwanda and Afghanistan, this outstanding volume demonstrates that newly emerging democracies need more than emergency economic support: restoring the rule of law can involve the training of a new police force, for example, or the creation of an international war crimes tribunal. Concluding with specific recommendations for the UN and EU members,Voorhoeve reminds us that disregard for human rights or delay in civilian reconciliation can lead to resurgences of violence. This title is available in the OAPEN Library - http://www.oapen.org.
    Keywords: Sociology ; Political Science ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
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    Learning from Experience (2023)
    RAND Corporation
    Details
    Publication Date: 2023-10-05
    Description: Describes the response of state and local health departments to outbreaks of Severe Acute Respiratory Syndrome (SARS), monkeypox, West Nile virus, and hepatitis A that took place from 1999 to 2003. In general, public health agencies demonstrated a robust ability to implement the major components of response to a public health emergency. Researchers found that the most pervasive problem involved communication difficulties within public health agencies and with public health partners.
    Keywords: Health Sciences ; Sociology ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNS Epidemiology & medical statistics ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFH Illness & addiction: social aspects
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    Los Angeles County Juvenile Justice Crime Prevention Act (2023)
    RAND Corporation
    Details
    Publication Date: 2024-04-02
    Description: California’s Juvenile Justice Crime Prevention Act provides funds for counties to offer evidence-based programs for high-need juvenile probationers and at-risk youth. This report, based on the annual report to the state legislature, outlines the program’s success for six outcome measures (completion of probation, restitution, and community service; arrests; probation violations; and incarcerations) and county-required supplemental outcomes.
    Keywords: Law ; History ; Political Science ; Sociology ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNF Criminal law: procedure and offences::LNFQ Juvenile criminal law ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKS Social welfare and social services::JKSW Emergency services::JKSW1 Police and security services ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology
    Language: English
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    Recent Progress of Nanomedicine and Targeted Drug Delivery for Cancer Treatment (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Currently, cancer is the second leading cause of death worldwide and is the most complex and challenging disease known to humankind. Due to the complex underlying mechanisms of tumorigenesis and tumor metastasis, as well as the intrinsic limitations of conventional cancer therapies, the effective treatment of cancer remains a great challenge. Novel therapeutic strategies with superior anticancer ability urgently need to be discovered. In recent years, nano-drug delivery systems have been extensively investigated and applied as alternatives to conventional cancer treatments. Cancer nanomedicines aim to achieve the targeted delivery of chemotherapeutic drugs to the tumor site, utilizing strategies such as passive targeting, active targeting and stimuli-triggered drug release, while simultaneously decreasing drug accumulation in normal tissues, which together lead to improved therapeutic efficacy and reduced side effects. Currently, several cancer nanomedicines are in regular use, and several others are in various stages of development.This Special Issue will highlight recent progress in the development of novel nanomedicines and targeted drug delivery systems for cancer therapy.
    Keywords: graphene quantum dot ; targeted drug delivery ; photothermal therapy ; chemo-therapy ; polymeric prodrug ; theranostic nanocomplex ; pH-triggering releasing ; magnetic targeting ; magnetic hyperthermia ; magnetic resonance imaging ; docetaxel ; adenosine receptors ; PLGA ; nanoparticles ; lung cancer ; Notch signaling ; RBPJ protein ; drug repurposing ; fidaxomicin ; acarbose ; schaftoside ; breast cancer ; experimental skin cancer ; entrapment efficacy ; ethosomes ; metformin ; in vitro permeation ; zeta potential ; sesamol ; albumin nanoparticles ; doxorubicin ; oxidative stress ; antioxidants ; tumor-derived membrane vesicles ; cancer therapy ; tumor vaccine ; personalized immunotherapy ; low-density lipoprotein ; nanoparticle ; tumor microenvironment-responsive ; magnetic nanofluid ; improved magnetic resonance imaging ; neutral-responsive Fenton reaction ; enhanced chemodynamic therapy ; brain targeting ; folate receptor ; glioma cancer ; erlotinib ; blood–brain barrier ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    New Multicultural Identities in Europe (2021)
    Leuven University Press
    Details
    Publication Date: 2024-03-29
    Description: How to understand Europe’s post-migrant Islam on the one hand and indigenous, anti-Islamic movements on the other? What impact will religion have on the European secular world and its regulation? How do social and economic transitions on a transnational scale challenge ethnic and religious identifications? These questions are at the very heart of the debate on multiculturalism in present-day Europe. Through the lens of post-migrant societies, manifestations of identity appear in pluralized and deterritorialized forms. This calls into question the nature of boundaries between, as well as within various ethnic-religious groups. Although the contributions in this volume focus on Islam, attention is also paid to Christianity, Judaism, and Hinduism. The authors present empirical data from cases in Turkey, Germany, France, Spain, the United Kingdom, Poland, Norway, Sweden and Belgium, and sharpen the perspectives on the religious-ethnic manifestations of identity in 21st-century Europe.
    Keywords: Sociology ; Islam studies ; Europe ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology
    Language: English
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    Extracellular Vesicle-Mediated Processes in Cardiovascular Diseases (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: It is long known that many cells can shed extracellular vesicles, small membrane-enclosed cell fragments. Although the existence of extracellular vesicles has been recognized for many years, researchers are only beginning to understand their physiologic significance. Several recent studies have demonstrated that extracellular vesicles released from cells serve as a mode of cellular communication. They can carry diverse molecular payload (e.g. nucleic acids, bioactive lipids and proteins) to distal organs and recipient cells. Extracellular vesicles can be classified into three major groups: exosomes, microvesicles, and apoptotic bodies. All these types of extracellular vesicles can be found in a variety of biologic specimen and their numbers, distribution and composition may serve as biomarkers for various disorders, including cardiovascular disease. Although extracellular vesicle-mediated processes are currently best characterized in the fields of cancer biology and neurobiology, evidence is accumulating that extracellular vesicles play a key role in the pathophysiology of diabetes, thrombosis, inflammation and cardiovascular calcification. In this Research Topic, we invited review and methodological articles that advance our understanding of extracellular vesicle-related processes in vascular biology.
    Keywords: R5-920 ; Angiogenesis ; Atherosclerosis ; Extracellular vesicles ; Calcification ; Biomarkers ; Cardiovascular disease ; Inflammation ; Exosomes ; Platelets ; Heart valve ; bic Book Industry Communication::M Medicine
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    Prognostic Factors for Pediatric Tumors (2024)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-01-08
    Description: In this Special Issue, recent advancements in the field of pediatric tumors are discussed, and novel prognostic markers are critically appraised. Greater understanding of the heterogeneity of pediatric cancers will ultimately lead to new therapeutic strategies with the potential to provide new prospects for precision medicine in pediatric oncology.
    Keywords: undernutrition ; obesity ; nutritional status ; childhood cancer ; overall survival ; event-free survival ; relapse ; treatment-related toxicity ; review ; sarcoma botryoides ; fertility-sparing surgery ; embryonal rhabdomyosarcoma ; genital tract ; prognosis ; treatment ; local debulking ; neoadjuvant chemotherapy ; radiation ; ovarian cancer ; adolescents ; diagnosis ; therapy ; guidelines ; children ; papillary thyroid cancer ; proto-oncogene B-raf gene (BRAF) ; craniopharyngioma ; recurrence ; risk factors ; youth ; acute lymphoblastic leukemia (ALL) ; child ; genetics ; CDKN2A/2B deletions ; fluorescent in situ hybridization (FISH) ; multiple-ligation probe amplification (MLPA) ; copy-number alterations (CNAs) ; risk stratification ; minimal residual disease (MRD) ; cardiotoxicity ; chemotherapeutics agents ; biomarkers ; omics technology ; medulloblastoma ; tumor ; histologic ; pediatrics ; micro-RNAs ; non-coding RNAs ; molecular subgroup ; stratification ; acute lymphoblastic leukemia ; proteomics ; oncology ; chemotherapy ; cardiac function tests ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Rethinking Interdisciplinarity across the Social Sciences and Neurosciences (2021)
    Springer Nature | Palgrave Macmillan
    Details
    Publication Date: 2024-04-01
    Description: This book offers a provocative account of interdisciplinary research across the neurosciences, social sciences and humanities. Setting itself against standard accounts of interdisciplinary 'integration,' and rooting itself in the authors' own experiences, the book establishes a radical agenda for collaboration across these disciplines. Rethinking Interdisciplinarity does not merely advocate interdisciplinary research, but attends to the hitherto tacit pragmatics, affects, power dynamics, and spatial logics in which that research is enfolded. Understanding the complex relationships between brains, minds, and environments requires a delicate, playful and genuinely experimental interdisciplinarity, and this book shows us how it can be done.
    Keywords: neurosciences ; interdisciplinarity ; social sciences ; interdisciplinary research ; integration ; humanities ; Des Fitzgerald ; Epistemology ; Sociology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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    Atlantic Bonds (2023)
    University of North Carolina Press
    Details
    Publication Date: 2024-04-02
    Description: A decade before the American Civil War, James Churchwill Vaughan (1828-1893) set out to fulfill his formerly enslaved father's dying wish that he should leave America to start a new life in Africa. Over the next forty years, Vaughan was taken captive, fought in African wars, built and rebuilt a livelihood, and led a revolt against white racism, finally becoming a successful merchant and the founder of a wealthy, educated, and politically active family. Tracing Vaughan's journey from South Carolina to Liberia to several parts of Yorubaland (present-day southwestern Nigeria), Lisa Lindsay documents this "free" man's struggle to find economic and political autonomy in an era when freedom was not clear and unhindered anywhere for people of African descent. In a tour de force of historical investigation on two continents, Lindsay tells a story of Vaughan's survival, prosperity, and activism against a seemingly endless series of obstacles. By following Vaughan's transatlantic journeys and comparing his experiences to those of his parents, contemporaries, and descendants in Nigeria and South Carolina, Lindsay reveals the expansive reach of slavery, the ambiguities of freedom, and the surprising ways that Africa, rather than America, offered new opportunities for people of African descent.
    Keywords: History ; American Studies ; African Studies ; Sociology ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas ; thema EDItEUR::N History and Archaeology::NH History::NHH African history ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFA Social discrimination and social justice
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    Polymer Materials in Biomedical Application (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-03-21
    Description: Recently, the development of polymeric materials for biomedical applications has advanced significantly. Polymeric materials are favored in the development of therapeutic devices, including temporary implants and three-dimensional scaffolds for tissue engineering and in vitro disease modelling.Further advancements have also occurred in the utilization of polymeric materials for pharmacological applications, such as delivery vehicles for drug release.We would like to invite you to contribute to this Special Issue. Research topics of interest include, but are not limited to, recent advances related to 3D cell culture, biomaterials, tissue engineering, disease modelling, hydrogel, organoids, drug discovery, bioimaging, cardio-renal, metabolic disease, and stem cell biology.
    Keywords: hydrogels ; crosslinking ; degradable ; gamma (γ)-irradiation ; sterilization ; sterility assurance ; antibacterial ability ; jojoba ; Simmondsia ; chemistry ; liquid wax ; biology ; toxicity ; pharmaceutical/industrial uses ; articular cartilage ; mechanical properties ; tribological properties ; antibacterial ; pathogens ; infectious diseases ; silver nanoparticles ; wound care ; wound dressings ; polymers ; gelatin ; nanofibers ; sponges ; Ag/RGO nanocomposites ; green preparation ; anticancer performance ; potential mechanism ; oxidative stress ; hydrogel ; poloxamer 407 polymer ; poloxamer 407 gel ; transungual drug delivery ; onychomycosis ; ungual penetration enhancer ; Terbinafine ; diafiltration ; SAXS ; aromatic interactions ; poly(sodium 4-styrenesulfonate) ; chlorpheniramine ; polyelectrolyte ; aggregation ; coaxial electrospinning ; extracellular matrix ; myelination ; oligodendrocyte ; water-soluble materials ; orthokeratology lens ; protein deposition ; optical characteristics ; rubbing ; chitosan ; kenaf ; nanocrystalline cellulose ; platelet lysate ; wound healing ; carbohydrate polymers blends ; functional food ; antioxidant activity ; co-microencapsulation ; spray drying ; bacteria viability (Bacillus clausii) ; probiotics ; itraconazole ; self-emulsifying nanovesicles ; transungual ; anti-fungal ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    How to improve immune reconstitution in allogeneic hematopoietic stem cell transplantation? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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    Return of the Jew (2021)
    Academic Studies Press
    Details
    Publication Date: 2022-05-02
    Description: A new, “unexpected” generation of Jews made an appearance in Poland following the fall of the communist regime. Once home to the greatest Jewish community in the world and then site of one of the biggest tragedies in Jewish history, today Poland is experiencing what some have called a “renaissance of Jewish culture.” Simultaneously, more and more Poles are discovering their Jewish roots and beginning to seek forms of Jewish affiliation. Can there be “authentic” Jewish life in Poland after fifty years of oppression? "Return of the Jew" offers the first in-depth study of the third post-Holocaust generation of Jews in Poland. It provides a revealing account of the experience of being or rather becoming Jewish vis-a-vis uniquely compelling circumstances.
    Keywords: Sociology ; Polish Jews ; Third Generation Jews ; Jewish roots ; Kazimierz ; Polish Jewish identity ; Polish Jewish cutlure ; Jewish identity ; identity ; Post-Holocaust generation ; Third generation Holocaust survivors ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSR Religious groups: social & cultural aspects::JFSR1 Jewish studies
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    Grenville Goodwin Among the Western Apache (2023)
    University of Arizona Press
    Details
    Publication Date: 2023-10-05
    Description: Grenville Goodwin was one of the leading field anthropologists during a crucial period in American Indian research-the 1930s. His letters from the field provide original source material on Western Apache beliefs and customs. They also reveal the attitudes and methods which made him so effective in his work. A dedicated and thorough ethnographer, Goodwin became familiar with every aspect of Western Apache culture. During this same period, Morris Opler was studying the Chiricahua and Mescalero Apache in New Mexico. In order to exchange information about their studies, Goodwin and Opler began corresponding. Both men were convinced that a long-overdue, systematic comparison of Apachean cultures would yield significant results.
    Keywords: Sociology ; Anthropology ; History ; American Indian Studies ; American Studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJK History of the Americas
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    Preschool Adequacy and Efficiency in California (2023)
    RAND Corporation
    Details
    Publication Date: 2023-10-05
    Description: The California Preschool Study examined gaps in school readiness and achievement in the early grades among California children and the potential for high-quality preschool to close those gaps, the use of early care and education (ECE) services and their quality, and the system of publicly funded ECE programs for three- and four-year-olds. This analysis integrates the results from the prior studies and makes recommendations for preschool policy.
    Keywords: Sociology ; Management & Organizational Behavior ; Education ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management::KJW Office & workplace::KJWX Working patterns & practices ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSP Age groups::JFSP1 Age groups: children
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    Rheumatic Diseases: Pathophysiology, Targeted Therapy, Focus on Vascular and Pulmonary Manifestations (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: This e-book summarises the latest advances in the rheumatic diseases with a focus on the recent efforts of vascular and pulmonary manifestations and anticipate the new and future directions of these research topic. Rheumatic diseases represent a heterogeneous group of severe autoimmune disorders. The present Special Issue aims to provide an overview of the complexity of vascular and pulmonary manifestations of rheumatologic diseases and helps in knowledge to manage them. The eleven published articles here collected underline the complexity of rheumatic diseases and the difficult to treated them. The manuscripts provide an overview of the pathophysiology and current treatment regimes of these disorders, highlighting tools which assist with diagnosis, risk stratification and therapy. Finally, we underline the importance of a multidisciplinary team working using the skills of clinicians, radiologists, and pathologists.
    Keywords: systemic sclerosis ; scleroderma ; interstitial lung disease ; pulmonary function tests ; high-resolution computed tomography ; rheumatic ; pulmonary arterial hypertension ; targeted therapy ; systemic lupus erythematosus ; airway disease ; shrinking lung syndrome ; diffuse alveolar hemorrhage ; pleurisy ; infection ; cardiopulmonary exercise testing ; osteopontin ; connective tissue diseases ; pulmonary involvement ; microvascular involvement ; nailfold capillaroscopy ; rheumatoid arthritis ; interstitial lung diseases ; CX3CL1/fractalkine ; CX3CR1 ; M1 macrophage ; M2 macrophage ; SKG mice ; heart failure ; 3D-echocardiography ; ventricular function ; outcome ; ventricular-arterial coupling ; antifibrotic agents ; COVID-19 ; IPF ; progressive fibrosing ILD ; UIP ; pharmacological interactions ; fibromyalgia ; gastrointestinal symptoms ; probiotic ; VSL#3® ; efficacy ; tolerability ; polymyalgia rheumatica ; vagus nerve stimulation ; inflammatory response ; PMR ; t-vns ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Recent advances in γδ T cell biology: New ligands, new functions, and new translational perspectives (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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    Traditional Medicines and Globalisation (2021)
    Maven Publishers
    Details
    Publication Date: 2022-04-28
    Description: The development of natural products requires the confluence of the modern techniques and integrated approaches in various fields of science and technology. Intention of this book is to highlight different aspects of globalization of traditional medicine with the focus on some crucial and contemporary issues on validation of natural products. Eminent scientists around the globe have contributed for this book on different issues of ethnopharmacology, traditional medicine and globalization. Given the importance on promotion and development of natural products, this book covers various aspects on revitalization of traditional medicines. The contributors have provided an insight into the modem aspects and future of traditional medicine inspired drug development, validation, safety related quality issues, sustainability and globalization. Bringing together expertise from academia and industry, this edited volume provides an overview of traditional medicine with wisdom and know-how in both innovation and commercialization, placing natural product research in a broader sense for readers. This edited volume contains 68 chapters emphasizing several thrust areas of ethnopharmacology and natural products. A wide diversity of chapters has been contributed by eminent personalities throughout the world including Dr. A. P. J. Abdul Kalam, Sri. Shekhar Dutt, Dr. Marco Leonti, Dr. G. A. Cordell, Dr. R. Verpoorte, Dr. P. J. Houghton, Dr. P. Pushpangadan, Dr. Y. K. Gupta, Dr. A.K.S. Rawat, Dr. S.K. Kulkarni, Dr. Colin W. Wright, Dr. S. C. Mandal, Dr. C. K. Katiyar, Dr. T. K. Mukherjee, Dr. S. Rajan, Dr. G. Schemda, Dr. P. K. Debnath, Dr. Bob Alkin, Dr. Elfin Y. Sukandar, Dr. N. Maity, Dr. A. K. Mitra, Dr. E. Hossain, Dr. H. Fukui, Dr. S.Bhadra, Dr. N. Neema, Dr. H. Mizuguchi, Dr. D. Chattopadhyay, Dr. T. Sen, Dr. Erdem Yesilada, Dr. S.K.Mitra, Dr. S.C. Bachar, Dr. S. Karmakar, Dr. G. B. J. Bailly, Dr. P. Haldar, Dr. Y. Oztruk, Dr. S. Pandit, and others. All representing the-state-of-the-art of the field, and thus would be interesting sources for information. This book will be of enormous help to the undergraduate and postgraduate students, researchers and academia and all others working in the area of Ethnopharmacology and natural product research. It will be an imperative addition to the libraries of technical and administrative personnel in the industries and Universities as a potential resource to update their knowledge.
    Keywords: Globalization ; traditional medicine ; bic Book Industry Communication::M Medicine
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    Disability and Poverty (2021)
    Policy Press
    Details
    Publication Date: 2024-03-28
    Description: This book is about being disabled and being poor and the social, cultural and political processes that link these two aspects of living in what has been characterised as a “vicious circle” (Yeo & Moore 2003). It is also about the strengths that people show when living with disability and being poor. How they try to overcome their problems and making the best out of what little they have. This book will appeal to academics, postgraduates and policymakers in disability studies, development studies, poverty and social exclusion.
    Keywords: Sociology ; Disability ; Malawi ; South Africa ; Zimbabwe ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBF Social and ethical issues::JBFM Disability: social aspects
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    Research Topics in Medicines and How Our Board Members Are Engaged in Them (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: With the development of analytical instruments, the academic system has become more complicated, producing new journals one after another. Therefore, it became much important to clarify what is original of “Medicines”. As the name Medicines indicates, it includes science and practice of caring for a patient and managing the diagnosis, prognosis, prevention, treatment or palliation of their injury or disease. Therefore, Medicines differs from other journals with similar title in that it covers a wide range of fields, from traditional medicine to rapidly developing molecular-targeted drugs, focusing on their pharmacological effects, structure–activity relationships, metabolic pathways, gene expression, using cultured cells, animals, and clinical trials. Most parts of this Special Issue were written by our editorial board members, who described the research topics and how they are engaged in their field of research. All of these articles are their life-long story. We collected a total number of 22 original works by basic researchers and clinical doctors. We hope that readers can get a chance to know the current status of diverse fields of medicines, and what your most important research themes are after reading these articles.
    Keywords: Hedychium ; traditional medicine ; coronarin D ; villosin ; anti-acetylcholinesterase ; antidiabetic ; anti-inflammatory ; antimicrobial ; antioxidant ; antitumor ; Genista tridentata ; Pterospartum tridentatum ; isoflavones ; flavonols ; genistein ; biochanin A ; rutin ; daidzein ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; extra-intestinal manifestations ; orofacial granulomatosis ; tag-like lesions ; cobblestoning ; mucogingivitis ; lip swelling ; aphthous stomatitis ; Angelicae Sinensis Radix ; Danggui ; granules ; herb ; multivariate analysis ; ultra-performance liquid chromatography ; Tai Chi ; qigong ; immune system ; immunity ; inflammation ; telemedicine ; remote monitoring ; GER-e-TEC ; elderly patient ; artificial intelligence ; geriatric syndromes ; detection of the precursory signs of decompensation of geriatric syndromes ; renal cell cancer ; genomic landscape ; targeted therapy ; tumor evolution ; tumor heterogeneity ; allergic rhinitis ; quercetin ; human CD4+ T cells ; Th1/Th2 cytokine balance ; modulation ; in vitro ; intravascular catheter ; CRBSI ; biofilm ; CVC ; antifouling ; chromone ; tumor specificity ; QSAR analysis ; apoptosis ; cell cycle analysis ; contrast-enhanced ultrasound ; hepatocellular carcinoma ; LI-RADS ; chronic liver disease ; granuloma annulare ; granulomatous disorders of the skin ; inflammatory skin conditions ; medical dermatology ; biliary tract cancer ; cholangiocarcinoma ; PARP ; BRCA ; olaparib ; rucaparib ; liver cancer ; pancreatic adenocarcinoma ; pancreatic cancer ; sarcoidosis ; superior vena cava syndrome ; venous thrombosis ; RUCAM ; Roussel Uclaf Causality Assessment Method ; diagnostic algorithm ; iDILI ; iDrug induced liver injury ; DILI ; HILI ; herb induced liver injury ; Stachys L. ; traditional uses ; pharmacological activities ; phytochemicals ; bioactive compounds ; Kampo formulae ; alkaline extract of Sasa sp. ; pine cone extract ; povidone-iodine ; HSV ; HIV ; loss of infectivity ; solubilization method ; diaphragmatic breathing ; abdominal breathing ; breathing exercise ; systematic review ; randomized controlled trial ; respiratory function ; auricular acupuncture ; preoperative anxiety ; protocol ; randomized controlled trials ; meta-analysis ; boiogito ; knee osteoarthritis ; rat ; Yokukansan ; fentanyl ; transient receptor potential ankyrin 1 (TRPA1) channel ; phosphorylated extracellular signal-regulated kinase (pERK) ; whole-cell patch-clamp recording ; herbal medicine ; calcium metabolism ; bone metabolism ; protease ; osteoclast ; macrophage ; RANKL ; LPS ; TLR4 ; TREM2 ; bic Book Industry Communication::M Medicine
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    Global health issues of aflatoxins in food and agriculture: Challenges and opportunities (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Aflatoxins are a group of polyketide mycotoxins that are produced mainly by members of the genus Aspergillus. Production of these toxic secondary metabolites is closely related to fungal development (Keller et al., 2005; Jamali et al., 2012). Contamination of food, feed and agricultural commodities by aflatoxins poses enormous economic and serious health concerns because these chemicals are highly carcinogenic and can directly influence the structure of DNA. The resulting genetic defects can lead to fetal misdevelopment and miscarriages; aflatoxins are also known to suppress immune systems (Razzaghi-Abyaneh et al., 2013). In a global context, aflatoxin contamination is a constant concern between the 35N and 35S latitude where developing countries are mainly situated. With expanding boundaries of developing countries, aflatoxin contamination has become a persistent problem to those emerging areas (Shams-Ghahfarokhi et al., 2013). The continuing threat by aflatoxin contamination of food, feed and agricultural commodities to the world population has made aflatoxin research one of the most exciting and rapidly developing study areas of microbial toxins. The present research topic includes six review articles, three mini reviews and four original research articles. Contributors highlight current global health issues arising from aflatoxins and aflatoxigenic fungi and cover important aspects of aflatoxin research including contamination of crops, epidemiology, molecular biology and management strategies. Special attention is given to fungus-plant host interactions, biodiversity and biocontrol, sexual recombination in aflatoxigenic aspergilli, potential biomarkers for aflatoxin exposure in humans and safe storage programs.
    Keywords: R5-920 ; QR1-502 ; Q1-390 ; TX341-641 ; genetic diversity ; Public Health ; Aspergillus flavus ; Genomics ; MicroRNAs ; Fungus host interactions ; biological control ; aflatoxin ; agricultural crops ; bic Book Industry Communication::M Medicine
    Language: English
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    Emerging Materials for Additive Manufacturing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: In this reprint, state-of-the-art research and review articles on emerging material systems for additive manufacturing (AM) are collected, with a focus on the process–structure–properties relationships. Additive manufacturing (AM) has grown and evolved rapidly in recent years. There are many exciting research and translational works in many areas of application, such as biomedical, aerospace and electronics. These advancements are typically coupled with materials development, which has resulted in more functionalities added to 3D-printed parts, such as multi-material fabrications and integration with machine learning or digital twins. Such enhancements in functionalities have enabled the evolution of AM from a rapid prototyping tool to an actual manufacturing solution. In this reprint, two reviews and thirteen original research articles are included to highlight the latest development in the field of materials science for AM.
    Keywords: titanium scaffolds ; 3D printing ; pore design ; selective laser melting ; lattice structures ; torsion ; design ; additive manufacturing ; functionally gradient lattice ; torsional stiffness ; energy absorption ; failure behavior ; ferritic steel ; heat treatment ; SLM ; nuclear application ; laser powder bed fusion ; solidification crack ; hot crack ; aluminum alloy powder ; EN AW-5083 ; AA5083 ; AlSi10Mg ; powder bed fusion ; metal matrix composites ; laser powder-bed fusion ; aluminum alloys ; reinforcement ; ceramic particulates ; grain refinement ; crystallographic texture ; mechanical properties ; laser-directed energy deposition ; melt pool ; process maps ; multi-fidelity Gaussian process ; Bayesian Optimization ; uncertainty quantification ; K418 alloy ; orientation ; phase ; microhardness ; color 3D printing ; penetration depth ; chromaticity ; image-based metric ; color reproduction ; Ti-24Nb-4Zr-8Sn ; titanium alloy ; biomedical engineering ; microstructure ; X-ray diffraction ; directed energy deposition ; shape-memory alloys ; joining of metals ; elemental powders ; 3D concrete printing (3DCP) ; hybrids ; geopolymer ; frost resistance ; UV radiation ; thermal conductivity ; surface finishing ; physical vapor deposition ; composites ; recycling ; polymer-matrix composites (PMCs) ; direct ink writing ; liquid deposition modeling ; glass fibers ; stainless steel ; AISI 316L ; AISI 630 (17-4PH) ; AISI 420 ; AISI 440C ; carbon content ; online monitoring ; electron beam melting ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Spaces and Identities in Border Regions (2021)
    transcript Verlag
    Details
    Publication Date: 2024-03-29
    Description: Spatial and identity research operates with differentiations and relations. These are particularly useful heuristic tools when examining border regions where social and geopolitical demarcations diverge. Applying this approach, the authors of this volume investigate spatial and identity constructions in cross-border contexts as they appear in everyday, institutional and media practices. The results are discussed with a keen eye for obliquely aligned spaces and identities and relinked to governmental issues of normalization and subjectivation. The studies base upon empirical surveys conducted in Germany, France, Belgium and Luxembourg.
    Keywords: Sociology ; Identity ; Space ; Border ; Culture ; Europe ; Society ; Cultural Anthropology ; Sociology of Culture ; Interculturalism ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology
    Language: English
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    Marine Compounds and Cancer (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: In Western countries, cancer is among the most frequent causes of death. Despite striking advances in cancer therapy, especially by the so called “targeted agents”, there is still an urgent need for new drugs in oncology. Hope comes from the marine environment, which is a rich source of natural compounds showing anti-cancer activity. To date, four marine cytotoxic substances, namely cytarabine, trabectidine, eribulin, and monomethyl auristatin E (as a drug-antibody conjugate named vedotin) have made it into clinical routine. Many more are in all phases of clinical testing, and a plethora of substances has already been examined for in vitro and in vivo activity. Interestingly, more and more precise research tools allow the dissection of the molecular mode of action of these cytotoxic substances, thereby uncovering the specific drug targets in cancer cells. This development will blur the edges between “targeted” and “untargeted” therapy, and will hopefully lead to a more directed use of cancer medicine (based on a molecular rationale of activity) in the future. This Topical Collection will cover the whole scope from agents with cancer-preventive activity, to novel and previously characterized compounds with anti-cancer activity, both in vitro and in vivo, and the latest status of clinical development from drug trials. Of note, compounds possessing pro-carcinogenic activity or mediating cancer cell survival are also within the scope of this Topical Collection. In addition, a special focus will be placed on current shortfalls and possible strategies to overcome obstacles in the area of marine anti-cancer drug development.
    Keywords: R5-920 ; toxicology ; marine toxins ; drug discovery ; marine natural compounds and their derivatives ; xenograft models ; drug combination ; cancer ; drug resistance ; cancer-preventive activity ; molecular effects ; molecular targets ; bic Book Industry Communication::M Medicine
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    Personalized Medicine for Parkinson's Disease (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: Personalized medicine for Parkinson’s disease is a growing and emerging concept in light of recent recognition that Parkinson’s is a syndromic condition affecting multiple neurotransmitter systems, as well as brain and extracranial structures. The clinical expression is, thus, heterogeneous, and presentation age can range from the 30s to the 90s, with PD in older patients being associated with significant neuropathological comorbidity as well, involving not just misfolded alpha synuclein deposition but also amyloid and tau. Traditional and largely guideline-driven “one size fits all” management strategies adopted in clinical practice are, therefore, often inadequate in holistic management of a patient, particularly when aspects of motor and nonmotor symptoms are taken into consideration. In this supplement of JPM, we present a selection of papers which address several possible strands of personalized medicine in PD, ranging from genomic precision medicine to digital “checklists” to ensure delivery of holistic personalized medicine involving nonpharmacological strategies, as well. We are soliciting any papers addressing biomarkers, genetics and pharmacogenetics, treatment or complementary therapies for personalized or individualized treatment for PD.
    Keywords: Parkinson’s disease ; movement disorders ; periodontitis ; periodontal disease ; hematologic tests ; Vitamin D ; oral health ; Parkinson’s Disease ; cognition ; GABAergic signaling ; cerebellum ; MRS ; response inhibition ; non-motor symptoms ; carer stress ; older persons with Parkinson’s disease ; education ; lifestyle behaviours ; diet ; cross-sectional ; population study ; neurological disorders ; precision medicine ; genetics ; clinical trials ; Parkinson’s disease (PD) ; cognitive rehabilitation ; intervention ; deep brain stimulation ; levodopa-carbidopa intestinal gel ; apomorphine ; radiofrequency ; focused ultrasound ; induced pluripotent stem cells ; cell therapy ; gene therapy ; personalized medicine ; advanced Parkinson’s disease (APD) ; apomorphine subcutaneous infusion therapy ; pain ; intrajejunal ; levodopa ; motor and non-motor symptoms ; PKG (KinetiGrap) ; rehabilitation ; device-aided therapies ; personalised medicine ; Alzheimer’s disease ; clinical trial ; impulsive-compulsive disorders (ICD) ; dopaminergic therapy ; genetic markers ; pharmacogenetic ; polymorphisms ; insomnia ; sleep quality ; assessment ; young onset Parkinson’s (YOPD) ; Emiratis ; expatriate ; genetic ; epigenetics ; societal impact ; device aided therapies ; quality of life ; non motor symptoms ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJN Neurology & clinical neurophysiology
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    Urological Cancer 2022 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: In the urological sphere, the number of tumor malignancies caused by cancer is continuously growing in Western countries. Although this is mainly due to the contemporary increase in the life expectancy of people in these geographic areas, many other factors are also contributing to this growth. Urological cancer is a complex and varied disease which affects different organs and mainly affects the male population. In fact, in most statistics, kidney, prostate, and bladder cancer are regularly included in the top-ten list of the most frequent neoplasms in males. The female population, however, has also been increasingly affected by renal and bladder cancer in the last decade. From these facts, it is clear that urological cancer is a problem of major concern in developed societies. This Topic Issue of Cancers intends to shed some light on the complexity of this field and will consider all useful and appropriate contributions from scientists and clinicians in order to improve urological cancer knowledge for patients’ benefit.
    Keywords: high-risk prostate cancer ; androgen receptor axis ; castration resistance ; neuroendocrine carcinoma ; PARP inhibition ; immunotherapy ; cancer genome ; precision targeting ; robot-assisted partial nephrectomy ; renal cell carcinoma ; indocyanine green ; nephron sparing ; prostate cancer survivors ; follow-up care ; primary health care ; general practice ; process evaluation ; Consolidated Framework for Implementation Research ; prostate-specific membrane antigen positron-emission tomography ; multiparametric magnetic-resonance imaging ; primary diagnosis ; prostate cancer ; systematic review ; diagnosis ; PSMA ; PSA ; tumor ; PET scan ; bladder cancer ; bisphenol A ; bisphenol S ; energy metabolism ; migration ; proliferation ; carbon-ion radiotherapy ; elderly patients ; radiotherapy ; particle beam therapy ; life expectancy ; systemic immune-inflammation index ; Charlson comorbidity index ; CAPRA-S ; early survival ; male incontinence ; robotic prostatectomy ; clear cell renal cell carcinoma ; ferroptosis ; prognostic model ; TCGA ; E-MTAB-1980 ; GLS2 ; pazopanib ; real-world data ; non-interventional study ; time on drug ; nivolumab ; everolimus ; trial-eligibility ; ureteral neoplasms ; urinary bladder neoplasms ; ureteroscopy ; CNTF ; CNTFRα ; LNCaP ; 22Rv1 ; castration resistant ; castration sensitive ; STAT3 ; ERK ; MMP ; biomarker ; Gleason grade ; transforming growth factor-β family ; activin ; INHBA ; INHBB ; INHBC ; prostate-specific antigen ; false-positive results ; real world-data ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
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    Epigenetics of B Cells and Antibody Responses (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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    Experimental models of early exposure to alcohol: a way to unravel the neurobiology of mental retardation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Excessive alcohol drinking represents a major social and public health problem for several countries. Alcohol abuse during pregnancy leads to a complex syndrome referred to as fetal alcohol spectrum disorders (FASD), chiefly characterized by mental retardation. The effects of early exposure to ethanol can be reproduced in laboratory animals and this helped to answer several key questions concerning the human pathology. The interest of experimental models of FASD is twofold. First, they increase our knowledge about the dose and modality of alcohol consumption able to induce damaging effects on the developing brain. Second, experimental models of FASD can provide useful hints to elucidate the basic mechanisms leading to the intellectual disability. In fact, experimental exposure to alcohol can be carried out during discrete, often very restricted, time windows. As a consequence, FASD models, though depending on the multifaceted interference of alcohol with several molecular pathways, can provide valuable information about which specific developmental periods and brain areas are critically involved in the genesis of mental retardation. Putting together data obtained through several experimental paradigms of alcohol exposure and those deriving from other genetic and non-genetic models, one can figure out to what extent different types of mental retardation share common pathogenetic mechanisms. The present Research Topic is aimed at establishing the state of the art of the current research on experimental FASD, focusing on differences and homologies with other types of intellectual disability. The ultimate goal is to find out a common roadmap in view of future therapeutical approaches.
    Keywords: R5-920 ; RC435-571 ; RJ1-570 ; glial cells ; development ; Amygdala ; Fetal Alcohol Spectrum Disorders ; Cerebral Cortex ; Intellectual Disability ; epigenetics ; Apoptosis ; bic Book Industry Communication::M Medicine
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    Alegal (2023)
    Fordham University Press
    Details
    Publication Date: 2023-10-05
    Description: Okinawan life, at the crossroads of American militarism and Japanese capitalism, embodies a fundamental contradiction to the myth of the monoethnic state. Suspended in a state of exception, Okinawans have never been officially classified as colonial subjects of the Japanese empire or the United States, nor have they ever been treated as equal citizens of Japan. As a result, they live amid one of the densest concentrations of U.S. military bases in the world. By bringing Foucauldian biopolitics into conversation with Japanese Marxian theorizations of capitalism, Alegal uncovers Japan's determination to protect its middle class from the racialized sexual contact around its mainland bases by displacing them onto Okinawa, while simultaneously upholding Okinawa as a symbol of the infringement of Japanese sovereignty figured in terms of a patriarchal monoethnic state. This symbolism, however, has provoked ambivalence within Okinawa. In base towns that facilitated encounters between G.I.s and Okinawan women, the racial politics of the United States collided with the postcolonial politics of the Asia Pacific. Through close readings of poetry, reportage, film, and memoir on base-town life since 1945, Shimabuku traces a continuing failure to "become Japanese." What she discerns instead is a complex politics surrounding sex work, tipping with volatility along the razor's edge between insurgency and collaboration. At stake in sovereign power's attempt to secure Okinawa as a military fortress was the need to contain alegality itself-that is, a life force irreducible to the legal order. If biopolitics is the state's attempt to monopolize life, then Alegal is a story about how borderland actors reclaimed the power of life for themselves. In addition to scholars of Japan and Okinawa, this book is essential reading for anyone interested in postcolonialism, militarism, mixed-race studies, gender and sexuality, or the production of sovereignty in the modern world. Alegal is available from the publisher on an open-access basis.
    Keywords: Sociology ; History ; Asian Studies ; Political Science ; Language & Literature ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSL Ethnic studies ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history ; bic Book Industry Communication::H Humanities::HB History::HBT History: specific events & topics::HBTQ Colonialism & imperialism ; bic Book Industry Communication::D Literature & literary studies::DS Literature: history & criticism::DSA Literary theory
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    Bringing up the Young with Global Values (2021)
    Ergon
    Details
    Publication Date: 2023-02-02
    Description: In today's seemingly globalized world, but full of rivalry between nations, races, and religions; confronted with different worldviews, ideologies, values and interests; the chances of peaceful co-existence seem to be rare. This work however envisages possible coexistence through a pedagogical approach. Today's global challenges have prompted the call for global values despite the heterogeneity of humanity. The prospect for such values must begin with a kind of 'value-mental-set', aimed at uniting the different kinds of humanity irrespective of colour, race, language, culture, religion or nationality of the individual. The route to the "promised Land" calls for human solidarity based on sustainable justice, partnership and friendliness; which takes cognizance of gender as well as intergenerational solidarity.
    Keywords: Sociology
    Language: English
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    e-Science (2021)
    Springer Nature | Springer
    Details
    Publication Date: 2024-03-29
    Description: This open access book shows the breadth and various facets of e-Science, while also illustrating their shared core. Changes in scientific work are driven by the shift to grid-based worlds, the use of information and communication systems, and the existential infrastructure, which includes global collaboration. In this context, the book addresses emerging issues such as open access, collaboration and virtual communities and highlights the diverse range of developments associated with e-Science. As such, it will be of interest to researchers and scholars in the fields of information technology and knowledge management.
    Keywords: Science and Technology Studies ; Media and Communication ; Business Information Systems ; Computer Applications ; Education, general ; Knowledge Management ; Science Communication ; Computer and Information Systems Applications ; Digital Education and Educational Technology ; Open Access ; Grid computing ; Science 2.0 ; Research network ; Education portal ; Virtual organization ; Governance ; Social control ; Science collaboration ; Digitization ; Digital research infrastructures ; Cyberinfrastructure software ; Sustainability ; Software sustainability ; Sociology ; Media studies ; Business mathematics & systems ; Information technology: general issues ; Education ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJQ Business mathematics and systems ; thema EDItEUR::U Computing and Information Technology::UB Information technology: general topics ; thema EDItEUR::J Society and Social Sciences::JN Education ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMK Knowledge management
    Language: English
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    Immune responses to AAV vectors, from bench to bedside (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
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    Marine Natural Products as Anticancer Agents 2.0 (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-07-14
    Description: Global cancer incidence and death are expected to increase in the next decades. Inappropriate therapeutic regimens and tumor recurrence due to the development of drug resistance are two major clinical challenges impacting poor patient outcomes, which is critical to the discovery and development of new anticancer drugs. Over the last few decades, the marine environment has proved to be a key source of molecules with potent anticancer properties. The Special Issue, “Marine Natural Products as Anticancer Agents 2.0”, gathered eleven publications, including two reviews and nine research articles, about the anticancer activities of marine natural and/or derived products on in vitro 2D and 3D cellular models, and/or in vivo models of colorectal, breast, lung, myeloma, liver, leukemia, and melanoma cancers. Altogether, the eleven scientific papers published in this Special Issue provide an exciting overview of marine natural products as potential anticancer agents.
    Keywords: Clavatadine C ; spirocyclic bromotyrosines ; cytotoxicity ; cancer selectivity ; marine compounds ; melanoma A-375 cell line ; Sarcophyton convolutum ; sarcoconvolutum A–E ; cembrenoids ; anti-angiogenesis ; bromophenols ; tube formation ; vasculogenic mimicry ; brefeldin A ; ester derivative ; chronic myelogenous leukemia ; BCR-ABL ; proliferation inhibition ; molecular modeling ; 5-O-(N-Boc-l-alanine)-renieramycin T ; Xestospongia sp. ; marine sponge ; lung cancer ; anti-cancer ; cancer stem cells ; apoptosis ; Akt ; c-Myc ; migrastatics ; cell migration ; cell invasion ; metastasis ; terpenes ; algae ; marine natural products ; mitochondrial dysfunction ; oxidative stress ; anticancer ; Sphaerococcus coronopifolius ; seaweed ; Laminaria japonica ; Laminaria japonica peptides ; cancer ; liver ; cell cycle ; porphyrin ; Isabela ; hemin ; X-ray diffraction ; NOESY NMR ; cytotoxic ; colorectal cancer ; 5-fluorouracil ; 7S,15R-dihydroxy-16S,17S-epoxy-docosapentaenoic acid ; tumor-associated macrophages ; chemoresistance ; fucoidan ; immunopotentiation ; immunomodulatory ; immunotherapy ; cancer treatment ; cytokines ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    CD4+ T cell differentiation in infection: amendments to the Th1/Th2 axiom (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
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    Chapter 32 The Roots and Ramifications of Narrative in Modern Medicine (2021)
    Edinburgh University Press
    Details
    Publication Date: 2024-04-01
    Description: In this landmark Companion, expert contributors from around the world map out the field of the critical medical humanities. This is the first volume to introduce comprehensively the ways in which interdisciplinary thinking across the humanities and social sciences might contribute to, critique and develop medical understanding of the human individually and collectively. The thirty-six newly commissioned chapters range widely within and across disciplinary fields, always alert to the intersections between medicine, as broadly defined, and critical thinking. Each chapter offers suggestions for further reading on the issues raised, and each section concludes with an Afterword, written by a leading critic, outlining future possibilities for cutting-edge work in this area. Topics covered in this volume include: the affective body, biomedicine, blindness, breath, disability, early modern medical practice, fatness, the genome, language, madness, narrative, race, systems biology, performance, the postcolonial, public health, touch, twins, voice and wonder. Together the chapters generate a body of new knowledge and make a decisive intervention into how health, medicine and clinical care might address questions of individual, subjective and embodied experience.
    Keywords: affect ; medical humanities ; experimentation ; mind ; body ; evidence ; imagination ; affect ; medical humanities ; experimentation ; mind ; body ; evidence ; imagination ; Case report ; Clinical psychology ; Disease ; Health care ; Medicine ; Narrative ; Narratology ; PatientsLikeMe ; Sociology ; thema EDItEUR::N History and Archaeology::NH History ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::M Medicine and Nursing ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBS Medical sociology
    Language: English
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    Communicating Medicine (2021)
    Ledizioni
    Details
    Publication Date: 2023-12-21
    Description: This study investigates eighteenth-century medical writing, particularly concerning the elaboration and the communication of medicine in such reference works as universal dictionaries of arts and sciences, medical dictionaries, and handbooks. Most of the vernacular texts under scrutiny here were issued in the second half of the century, a period in which the advancements in medical research, medical education and medical practice favoured the circulation of an expanding medical vocabulary and stimulated medical writing as a whole. A vast amount of reference works was produced for experts and non-experts alike: medical topics were common in social settings, in personal and communal letters, in specialised journals, in pamphlets and in magazines. All this unprecedented activity certainly contributed to the vernacularisation, and the dissemination of medicine in different kinds of works and different text types. The texts examined in the study are representative of their authors’ effort to expand medical knowledge and to define medicine as an independent science based on strict observation, as well as to establish intelligibility within and outside the disciplinary discourse community.
    Keywords: R5-920 ; english ; medicine ; language ; communication ; bic Book Industry Communication::M Medicine
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    The Rhythm of Strategy (2023)
    Amsterdam University Press
    Details
    Publication Date: 2024-03-30
    Description: This book provides a well-documented analysis of the strategy of the Salim Group, one of the largest family conglomerates in Southeast Asia. Using a multitude of sources, including interviews with the Salim family and Salim Group managers, the author provides a comprehensive corporate biography of this fascinating family firm. The Rhythm of Strategy: A Corporate Biography of the Salim Group of Indonesia criticises existing theories on ethnic Chinese firms and instead provides a more nuanced view of the evolution of a small migrant trading business into the largest family business group in Southeast Asia. It argues that the strategy of this group oscillated irregularly between a business model built on connections and a professional business model adapted to markets. Due to its size and closeness to the Suharto regime, the Salim Group has played an important role in shaping Indonesia's economy. This title is available in the OAPEN Library - http://www.oapen.org.
    Keywords: Sociology ; Economics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
    Language: English
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    Extracellular Vesicles: Biology and Potentials in Cancer Therapeutics (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-02-01
    Description: Extracellular vesicles (EVs) are particles wrapped in a lipid bilayer membrane and are naturally released from cells. This kind of cargo vessel is a nanostructure that mainly transfers lipids, proteins, various nucleic acid fragments, and metabolic components to neighboring cells or distant parts of the body through the circulatory system. EVs are of great significance to the communication mechanism between cells. This book collects feature articles to enhance our understanding of the biological characteristics of EVs and their potential applications.
    Keywords: extracellular vesicle ; precision oncology ; cancer biomarker ; prostate cancer ; drug delivery ; extracellular vesicles ; lysosome ; nanocarriers ; ultrasound ; size exclusion chromatography ; differential ultracentrifugation ; head and neck squamous cell carcinoma (HNSCC) ; exosomes ; cancer ; biomarker ; diagnostic ; therapy ; liquid biopsy ; small extracellular vesicles (sEV) ; tumor-derived exosomes (TEX) ; melanoma cell-derived exosomes (MTEX) ; proteomics ; tumor microenvironment ; biomarkers ; ectosomes ; neoplasia ; microvesicles ; small extracellular vesicles ; isolation ; purification ; size-exclusion chromatography ; ultracentrifugation ; sucrose density cushion ; lymph node ; spleen ; solid tissue ; microvesicle ; exosome ; cancer therapeutic ; drug carrier ; flow cytometry ; immunophenotyping ; swarm detection ; tumor-associated macrophages ; macrophage polarization ; mannose receptor ; HIV-1 Nef ; glioblastoma ; microRNA ; immunoprecipitation ; CD44 ; human milk ; nutrient ; microbiota ; microRNAs ; nanocommunicator ; diagnostic biomarker ; drug delivery vehicle ; personalized cancer immunotherapy ; therapeutic agents ; cell-to-cell communication ; ionising radiation ; non-targeted effects ; signalling ; imaging flow cytometry ; biomarker reservoirs ; cancer diagnostics ; disease monitoring ; large EVs ; ovarian cancer cells ; ES-2 ; OAW-42 ; adipose tissue origin mesenchymal stem cells ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Lipid Signaling in T Cell Development and Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
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    Foundations of Paleoparasitology (2021)
    SciELO Books - Editora FIOCRUZ
    Details
    Publication Date: 2023-12-21
    Description: Unprecedented initiative in the world, the book compiles the available knowledge on the subject and presents the state-of-the-art in paleoparasitology – term coined about 30 years ago by Brazilian Fiocruz researcher Luiz Fernando Ferreira, pioneer in this science which is concerned with the study of parasites in the past. Multidisciplinary by essence, paleoparasitology gathers contributions from social scientists, biologists, historians, archaeologists, pharmacists, doctors and many other professionals, either in biomedical or humanities fields. With varied applications such as in evolutionary or migration studies, their results often depend on the association between laboratory findings and cultural remains. The book is divided into four parts - Parasites, Hosts, and Human Environment; Parasites Remains Preserved in Various Materials and Techniques in Microscopy and Molecular Diagnostics; Parasite Findings in Archeological Remains: a paleographic view; and Special Studies and Perspectives. Signed by authors from various countries such as Argentina, USA, Germany and France, the book has chapters devoted to the discoveries of paleoparasitology on all continents.
    Keywords: R5-920 ; MEDICAL ; bic Book Industry Communication::M Medicine
    Language: English
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    Asian Literary Voices (2023)
    Amsterdam University Press
    Details
    Publication Date: 2024-03-23
    Description: Brings together some of the most exciting recent scholarship on Asian literature and culture, emphasising East Asia yet extending to South Asia Combines original findings of interest to specialists with a clear style of writing and argumentation that makes the volume accessible and appealing to the general reader Brings to life a wide range of Asian literary and scholarly figures important in their time and remain relevant and yet whose significance has been poorly understood This title is available in the OAPEN Library - http://www.oapen.org.
    Keywords: Art & Art History ; Sociology ; Language & Literature ; thema EDItEUR::A The Arts::AG The Arts: treatments and subjects::AGA History of art ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSA Literary theory ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies
    Language: English
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    Advances in the Diagnosis and Treatment of Thyroid Carcinoma (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-10-25
    Description: This reprint is related to the latest research in the field of thyroid surgery, including molecular and imaging diagnosis, surgical treatment, and the treatment of recurrent disease and advanced thyroid carcinoma.
    Keywords: thyroid carcinoma ; prophylactic central lymph node dissection ; lymph node metastases ; RET ; medullary thyroid carcinoma ; clinical management ; variants of uncertain significance ; differentiated thyroid cancer ; papillary thyroid cancer ; minimal extrathyroidal extension ; radioactive iodine therapy ; prognosis ; TNM ; histology ; multifocality ; lymph node metastasis ; vascular invasion ; autoimmune thyroid diseases ; radioiodine refractory ; Lenvatinib ; 18F-FDG-PET/CT ; cost-benefit analysis ; economics ; medical ; thyroid neoplasms ; radiomics ; ultrasound ; magnetic resonance imaging ; computer tomography ; prediction ; classification ; angiogenic microenvironment ; prognostic factors ; antiangiogenic therapy ; therapeutic target ; tumor microenvironment ; tumor behavior ; proliferation pathways ; cell cycle control pathways ; angiogenesis process ; thyroid cancer ; Gal-3 expression ; NIFTP ; EFVPTC ; lymphocytic thyroiditis (LT) ; immunohistochemical (IHC) analysis ; molecular imaging ; theranostics ; companion diagnostics ; immunoPET ; anaplastic thyroid cancer ; poorly thyroid cancer ; genetic landscape ; genetically guided therapy ; fluorodeoxyglucose F18 (18F-FDG) ; positron emission tomography (PET) ; magnetic resonance imaging (MRI) ; recurrence ; neoplasm metastasis ; thyroid surgery ; hypoparathyroidism ; fluorescence-guided surgery ; near-infrared autofluorescence ; PRKAR1A ; PKA ; Carney complex ; cAMP ; bone metastasis ; metastasectomy ; stereotactic radiosurgery ; ultrasound imaging ; thyroid nodule ; fine-needle aspiration ; papillary thyroid carcinoma ; lobectomy ; operative extent ; CONUT score ; tyrosine kinase inhibitors ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MJ Clinical & internal medicine::MJC Diseases & disorders::MJCL Oncology
    Language: English
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    The Role of Technology in Improving K-12 School Safety (2023)
    RAND Corporation
    Details
    Publication Date: 2024-03-29
    Description: The report categorizes school safety technologies, noting the lack of research about school safety technology and summarizing the existing research on school violence; presents six case studies of innovative technologies used in schools; and summarizes experts’ views of technologies and safety problems, determined through interviews; and presents experts’ rankings of technology needs to improve school safety, produced during two day-long panels.
    Keywords: Sociology ; Law ; Psychology ; Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LNF Criminal law & procedure::LNFQ Juvenile criminal law ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMC Child & developmental psychology ; thema EDItEUR::J Society and Social Sciences::JN Education::JNF Educational strategies and policy ; thema EDItEUR::L Law::LN Laws of specific jurisdictions and specific areas of law::LNF Criminal law: procedure and offences::LNFQ Juvenile criminal law ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMC Child, developmental and lifespan psychology
    Language: English
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    Biomedical Insights that Inform the Diagnosis of ME/CFS (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a severe chronic health condition that is often misunderstood or ignored by health establishments. The lack of definitive diagnostic markers to separate ME/CFS patients from the healthy population as well as from other chronic disorders is problematic for both health professionals and researchers. A consortium of Australian researchers gathered to systematically understand ME/CFS, ranging from a deep analysis of clinical and pathology data to metabolomic profiles and the investigation of mitochondrial function. From this broad collaboration, a number of compelling insights have arisen that may form the basis of specific serum, blood, and/or urinary biomarkers of ME/CFS. This Special Edition reports on a conference centred on these biomedical discoveries, with other contributions, with a translation focus for predictive markers for ME/CFS diagnosis. By supporting health professionals with developments in diagnostics for this condition, the patients and their families will hopefully benefit from an improved recognition of the biomedical underpinnings of the condition and will be better able to access the care that is urgently required. This Special Edition contains a mix of speaker submissions and other accepted manuscripts that contributed to our objective of advancing biomedical insights to enable the accurate diagnosis of ME/CFS.
    Keywords: R5-920 ; RM1-950 ; fatigue syndrome ; n/a ; work rehabilitation ; tryptophan metabolism ; substrate inhibition ; myalgic encephalomyelitis ; 3-dioxygenase ; ME (Myalgic Encephalomyelitis) ; assessment ; myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) ; muscles ; hypoacetylation ; circadian rhythm ; immune system ; chronic ; CFS (Chronic Fatigue Syndrome) ; energy metabolism ; ME/CFS ; immunological ; cytokine ; bistability ; diagnosis ; biomarker ; symptoms ; kynurenine pathway ; inflammation and immunity ; metabolism ; neuro-inflammation ; pathology ; signaling ; exercise ; Epstein Barr virus ; methylhistidine ; hypothalamic–pituitary–adrenal axis ; potential biomarkers ; critical point ; inflammation ; histone deacetylation ; participatory research ; neurology ; neuroimmune ; activin ; mitochondria ; patient-driven questionnaire ; medical retirement ; machine learning ; prognosis ; gut microbiota ; post-exertional malaise ; chronic fatigue syndrome ; mathematical model ; reference intervals ; diagnostic biomarker ; indoleamine-2 ; bic Book Industry Communication::M Medicine
    Language: English
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    Programming the HPA-axis by early life experience: Mechanisms of stress susceptibility and adaptation (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Experiences during early life program the central nervous- and endocrine-systems with consequences for susceptibility to physical and mental disorders. These programming effects depend on genetic and epigenetic factors, and their outcome leads to an adaptive or maladaptive phenotype to a given later environmental context. This Research Topic focused on the hypothalamus-pituitary-adrenal (HPA)-axis and stress-related phenotypes, and on how HPA-axis programming by the environment precisely occurs. We included original research, mini-review and review papers on a broad range of topics related to HPA-axis programming.
    Keywords: R5-920 ; RC648-665 ; RC321-571 ; Q1-390 ; HPA axis ; Vulnerability ; resilience ; early life stress ; materna ; bic Book Industry Communication::M Medicine
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    The Challenges of COVID-19 with Obesity-Related Cancers (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-05-11
    Description: This reprint emphasizes the perspectives and challenges surrounding COVID-19 and obesity-related cancers, including but not limited to the risk factors of severe COVID-19 in cancer patients; the complications of COVID-19 in cancer patients; the challenges in cancer treatment and surgery; guidelines for cancer care during COVID-19; delayed diagnosis and suboptimal cancer management; the impact of COVID-19 on cancer screening, early diagnosis and cancer presentation; immune response after SARS-CoV-2 infection and vaccination in cancer patients; psychological distress among cancer survivors; telehealth in cancer care; the role of diet and nutraceuticals in the prevention of severe COVID-19 and cancer; and the effects of COVID-19 pandemic on cancer research.
    Keywords: COVID-19 ; neutropenia ; G-CSF treatment ; respiratory failure ; colorectal neoplasms ; gastrointestinal neoplasms ; immune checkpoint inhibitors ; neoplasms ; oncogenic viruses ; oncolytic virotherapy ; post-acute COVID-19 syndrome ; reactive oxygen species ; tumor escape ; SARS-CoV-2 ; thyroid cancer ; differentiated thyroid cancer ; COVID-19 severity ; inflammation ; immunity ; oxidative stress ; obesity ; SARS-Cov-2 ; oncology ; cancer screening ; clinical trials ; melanoma ; management ; pandemic ; teledermatology ; diagnostic delay ; immunotherapy ; vaccination ; lymph adenopathy ; cancer ; nutraceuticals ; supplements ; colorectal ; meta-analysis ; gynecologic oncology ; malignancy ; blood cancer ; hematologic malignancy ; leukemia ; lymphoma ; multiple myeloma ; myelodysplasia ; breast cancer ; cancer care ; screening ; surgery ; psychological distress ; cancer therapies ; immunogenicity ; safety ; vaccine hesitancy ; tumor subtype ; mortality ; intensive care unit ; medico-administrative data ; France ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Class Matters (2023)
    Pluto Books
    Details
    Publication Date: 2024-03-29
    Description: Social class remains a fundamental presence in British life in the twenty-first century. It is woven into the very fabric of social and political discourse, undiminished by the end of mass industry; unaugmented despite the ascendancy of 'ordinary working people' and other substitute phrases. Absent from this landscape, however, is any compelling Marxist expression or analysis of class. In Class Matters, Charles Umney brings Marxist analysis out of the 19th century textiles mill, and into the call centres, office blocks and fast food chains of modern Britain. He shows how core Marxist concepts are vital to understanding increasing pay inequality, decreasing job security, increasing routinisation and managerial control of the labour process. Providing a critical analysis of competing perspectives, Umney argues that class must be understood as a dynamic and exploitative process integral to capitalism - rather than a descriptive categorisation - in order for us to better understand the gains capital has made at the expense of labour over the last four decades.
    Keywords: Sociology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
    Language: English
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    The European Union, Turkey and Islam (2023)
    Amsterdam University Press
    Details
    Publication Date: 2024-03-29
    Description: Does the fact that the majority of Turkey's population is Muslim form a hindrance to its EU membership? According to a recent policy advice by the Netherlands Scientific Council for Government Policy (WRR), the answer is an adamant 'no'. Why is this issue of Turkish Islam relevant? After all, Turkey should not be judged by standards other than the Copenhagen criteria. The answer is that the public debate outside 'Brussels' will not be limited to these official criteria. Many people in Europe are worried about Turkey's 'Islam factor'. They believe that Muslims are (potentially violent) fundamentalists who want to establish a theocracy. By explicitly examining the role of Turkish Islam and Muslims in Turkey, the WRR wants to contribute to a well-informed European public debate on Turkey's accession. This title is available in the OAPEN Library - http://www.oapen.org.
    Keywords: Political Science ; Sociology ; Religion ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics ; bic Book Industry Communication::H Humanities::HR Religion & beliefs::HRL Aspects of religion (non-Christian)::HRLB Theology ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRV Aspects of religion::QRVG Theology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
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    Transformations of Gender in Melanesia (2023)
    ANU Press
    Details
    Publication Date: 2024-03-28
    Description: Despite the plethora of research on gender and the many projects designed to improve their status in the Pacific region, women continue to be disadvantaged and marginalised in social, economic and political spheres. How are we to understand this and what does it mean for researchers, policy-makers and development practitioners? This book examines these questions, partly by looking back but also by continuing the effort to explain and understand gender inequities in the Pacific through reference to the concept of societies in transition. The contributors discuss emerging masculinities and femininities in the Pacific in order to chart the development of these in their contexts. Exploring how contemporary Pacific identities are shaped by local contexts and traditions, they focus on how these are remade through interaction with global ideas, images and practices, including new forms of Christianity and economic transformations. Grounded in recent, original research in both the villages and towns of Melanesia, the collection engages with the study of gender in Melanesia as well as scholarship on global modernities.
    Keywords: Sociology ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups
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    The Schistosomiasis Vaccine - It Is Time to Stand Up (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
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    Allergic Rhinosinusitis and Airway Diseases (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-20
    Description: This Book, entiled “Allergic Rhinosinusitis and Airway Diseases”, presents the concept of united airway disease interaction, which comprises chronic rhinosinusitis and other lower airway disorders such as asthma. This concept furthers a deeper comprehension on the pathophysiology and management of upper and lower airway diseases. In this Book, the published papers cover different interesting topics such as healthcare equality, advanced biomarkers, accurate diagnosis and treatment, occupational exposure-induced upper airway allergy and neoplastic disease mimicking chronic rhinosinusitis.
    Keywords: chronic rhinosinusitis ; B-cell lymphoproliferative disorder ; sinus ; nasal allergies ; tannery worker ; Kanpur ; asthma ; ovalbumin ; saffron ; salbutamol ; IL’s ; TNF-α ; allergic rhinitis ; bronchial asthma ; allergy ; Th17 cells ; IL-17 ; IL-33 ; microRNA ; miR ; airway mucosal inflammation ; united airway disease ; acute rhinosinusitis ; acute recurrent rhinosinusitis ; Mediterranean diet ; nutritional evaluation ; nutritional therapy ; olfactory dysfunction ; anosmia ; post-acute COVID-19 ; nitric oxide ; NO ; exhaled NO ; FENO ; nasal peak flow ; atopic status ; total IgE ; specific IgE ; childhood asthma ; immunoblot ; ImmunoCAP ; otolaryngology ; sinusitis ; ethnic groups ; patient-reported outcome measures ; quality of life ; social justice ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Chasing the Chinese Dream (2021)
    Springer Nature | Springer Singapore
    Details
    Publication Date: 2024-04-02
    Description: This open access book explores the historical, cultural and philosophical contexts that have made anti-poverty the core of Chinese society since Liberation in 1949, and why poverty alleviation measures evolved from the simplistic aid of the 1950s to Xi Jinping’s precision poverty alleviation and its goal of eliminating absolute poverty by 2020. The book also addresses the implications of China’s experience for other developing nations tackling not only poverty but such issues as pandemics, rampant urbanization and desertification exacerbated by global warming. The first of three parts draws upon interviews of rural and urban Chinese from diverse backgrounds and local and national leaders. These interviews, conducted in even the remotest areas of the country, offer candid insights into the challenges that have forced China to continually evolve its programs to resolve even the most intractable cases of poverty. The second part explores the historic, cultural and philosophical roots of old China’s meritocratic government and how its ancient Chinese ethics have led to modern Chinese socialism’s stance that “poverty amidst plenty is immoral”. Dr. Huang Chengwei, one of China’s foremost anti-poverty experts, explains the challenges faced at each stage as China’s anti-poverty measures evolved over 70 years to emphasize “enablement” over “aid” and to foster bottom-up initiative and entrepreneurialism, culminating in Xi Jinping’s precision poverty alleviation. The book also addresses why national economic development alone cannot reduce poverty; poverty alleviation programs must be people-centered, with measurable and accountable practices that reach even to household level, which China has done with its “First Secretary” program. The third part explores the potential for adopting China’s practices in other nations, including the potential for replicating China’s successes in developing countries through such measures as the Belt and Road Initiative. This book also addresses prevalent misperceptions about China’s growing global presence and why other developing nations must address historic, systemic causes of poverty and inequity before they can undertake sustainable poverty alleviation measures of their own.
    Keywords: History of China ; Urban Studies/Sociology ; Organizational Studies, Economic Sociology ; Contemporary Literature ; Urban Sociology ; Economic Sociology ; Open Access ; Precision Poverty Alleviation ; Minority Poverty in China ; Unequal Regional Development in China ; Xi Jinping Fights Poverty ; China and Sustainable Development Goals for 2030 ; Morality and Ethics of Poverty Alleviation ; Asian history ; Sociology ; Urban communities ; Sociology: work & labour ; Literary studies: c 1900 to c 2000 ; thema EDItEUR::N History and Archaeology::NH History::NHF Asian history ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology::JHBL Sociology: work and labour ; thema EDItEUR::D Biography, Literature and Literary studies::DS Literature: history and criticism::DSB Literary studies: general::DSBH Literary studies: c 1900 to c 2000
    Language: English
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    Less and Non-invasive Hemodynamic Monitoring Techniques (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: In the perioperative setting and in intensive care medicine, early and effective hemodynamic management including fluid therapy and administration of vasoactive drugs to maintain vital organ perfusion and oxygen delivery is mandatory. Understanding the different approaches in the management of critically ill patients during the resuscitation and further management is essential to initiate adequate context- and time-specific interventions. Optimization of hemodynamic variables to achieve a balance between organ oxygen delivery and consumption is a cornerstone. In general, cardiac output (i.e., the blood flow) is considered a major determinant of oxygen supply and thus its monitoring is regarded helpful. However, indicators of oxygen requirements are equally necessary to assess adequacy of oxygen supply. Currently, more and more less or even totally non-invasive monitoring systems have been developed and clinically introduced, but they require validation in particular clinical settings. Cardiac output monitors and surrogates of organ oxygenation only enable to adequately guide management, as patient’s outcome is determined by acquisition and interpretation of accurate measurements, and finally, suitable management decisions. This Research Topic focuses on the currently available techniques, especially the less and non-invasive ones, in the field of hemodynamic monitoring in the perioperative setting and in critically ill patients while summarizing their advantages and limitations.
    Keywords: R5-920 ; Blood Pressure ; Cardiovascular dynamics ; goal-directed therapy ; intensive care medicine ; Cardiac Output ; Anesthesiology ; bic Book Industry Communication::M Medicine
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    Clarity, Cut, and Culture (2024)
    New York University Press | NYU Press
    Details
    Publication Date: 2024-04-07
    Description: Images of diamonds appear everywhere in American culture. And everyone who has a diamond has a story to tell about it. Our stories about diamonds not only reveal what we do with these tiny stones, but also suggest how we create value, meaning, and identity through our interactions with material culture in general. Things become meaningful through our interactions with them, but how do people go about making meaning? What can we learn from an ethnography about the production of identity, creation of kinship, and use of diamonds in understanding selves and social relationships? By what means do people positioned within a globalized political-economy and a compelling universe of advertising interact locally with these tiny polished rocks? This book draws on 12 months of fieldwork with diamond consumers in New York City as well as an analysis of the iconic De Beers campaign that promised romance, status, and glamour to anyone who bought a diamond to show that this thematic pool is just one resource among many that diamond owners draw upon to engage with their own stones. The volume highlights the important roles that memory, context, and circumstance also play in shaping how people interpret and then use objects in making personal worlds. It shows that besides operating as subjects in an ad-burdened universe, consumers are highly creative, idiosyncratic, and theatrical agents.
    Keywords: Anthropology ; Sociology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology
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    Model-Informed Precision Dosing (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-04-05
    Description: Model-informed precision dosing (MIPD) is an advanced quantitative approach focusing on individualized treatment optimization. MIPD integrates mathematical models of drugs and diseases combined with individual patient characteristics (e.g., genotype, anthropometric factors, and organ function). MIPD has been highlighted as a useful tool for drug dosage selection in both the drug development process and clinical practice and it is a rapidly growing discipline that is supported by the main drug regulatory agencies. Despite the potential benefits of this methodology toward personalized medicine, its application is still limited. The Special Issue presented here includes several PKPD and PBPK models focused on improving the current state of art regarding the PK behaviour of different drugs with the aim of improving the efficacy/safety balance of these treatments and their clinical outcome; the Special Issue is intended to be of particular interest for clinical pharmacologists, pharmacometricians, and specific clinicians who routinely use the considered drugs.
    Keywords: model-informed precision dosing (MIPD) ; efficacy PKPD indexes ; pharmacokinetics ; pharmacodynamics ; PKPD modeling and simulation ; dosing algorithms ; nomograms ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries
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    Ionizing Radiation, Antioxidant Response and Oxidative Damage: Radiomodulators (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-09-11
    Description: Ionizing radiation (IR) exposure can be deleterious for living tissues and eventually lead to illness or even death. DNA breakdown and the overproduction of highly reactive free radicals, reactive oxygen species (ROS) and reactive nitrogen species (RNS) are considered initiators of IR-induced molecular and cellular damages, whereas NO, TGF-β and other pro-inflammatory cytokines are the primary effectors involved in radiation bystander effects (RIBE). Radiomodulators can reduce (radioprotectors and radiomitigators) or increase (radiosensitizers) IR damage. Past world events have highlighted the urgent need to develop predictive biomarkers of the IR absorbed dose and radiation countermeasures to reduce IR damage. Despite the strong economic and scientific efforts over the last decades, at present, drugs for effective protection against lethal IRs remain an unmet need. Moreover, the development of radiosensitizers that selectively increase IR damage in cancer cells but protecting, or at least do not affect, healthy tissues is also of unquestionable importance to improving patient survival and quality of life. It includes contributions that will help to understand the mechanisms involved in radiation-derived cellular responses and damage, the importance of free radical scavengers and antioxidant cellular defenses in preventing harm, and the relevance of the antiinflammatory response to improve recovery. In accordance, the mechanism of action and effectiveness of relevant radiomodulators are described and discussed, and novel clinical models and IR biomarker technologies are presented.
    Keywords: ferulic acid ; total body irradiation ; bone marrow microenvironment ; stem cell senescence ; bone marrow injury ; reactive oxygen species ; antioxidant defense system ; planarians ; model animal ; irradiation ; regeneration ; radioprotection ; radiation ; melatonin ; nDNA-repair ; mtDNA-mutations ; oxidation stress ; protection ; mitigation ; H2O2 ; ATP ; MDA ; GSH ; X-ray radiation ; 3T3 fibroblasts ; proliferation ; apoptosis ; cellular stress ; senescence ; peroxiredoxin 6 ; Prdx6 ; radioprotector ; pharmacologic ascorbate ; vitamin C ; pancreatic cancer ; Auranofin ; thioredoxin ; thioredoxin reductase ; peroxiredoxin ; nuclear and radiological emergencies ; radioprotectors ; radiomitigators ; radionuclide scavengers ; radiation biodosimetry ; Olea europaea L. cv. Caiazzana ; oleacein ; ionising radiation ; cancer ; radiotherapy ; normal tissue ; radiosensitization ; radiomodulation ; proteomic analysis ; oxidative modification profiling ; serum albumin ; amino acid sequences ; radiation biomarker ; human lactoferrin ; acute gamma irradiation ; C57Bl/6 mice ; survival rate ; open field test ; spleen ; serum homeostasis ; leukocytes ; stilbenoid ; electron paramagnetic resonance (EPR) ; FT-IR ; electron beam radiation ; radioresistance ; oxidative phosphorylation ; oncometabolites ; radiation response ; bioinformatics ; oxidative stress ; transcriptomics ; radiobiology database ; gene signature ; ionizing radiation ; intestine ; mucositis ; microbiome ; microbiota ; dysbiosis ; bacterial dietary supplement ; radiomitigator ; hyperthermia ; combination therapy ; synergistic effect ; oxygenation ; hypoxia ; immune response ; Tameron ; antioxidant ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology
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    Civic Insecurity (2023)
    ANU Press
    Details
    Publication Date: 2023-10-05
    Description: Papua New Guinea has a complex 'law and order' problem and an entrenched epidemic of HIV. This book explores their interaction. It also probes their joint challenges and opportunities—most fundamentally for civic security, a condition that could offersome immunity to both. This book is a valuable and timely contribution to a limited but growing body of scholarship in the social and structural contexts of HIV epidemiology in Papua New Guinea. The volume offers a unique collection of interdisciplinary insights on the connections between law and order and the HIV epidemic and is presented in a manner accessible to a wide audience, scholars and lay people alike… Significantly, this is the first volume to critically examine the complex and inexorable links between HIV, gender, violence, and security within a theoretical framework thv at illuminates the challenges of the epidemic for PNG's future cohesion and stability as a young nation…The importance of this courageous book cannot be overstated. While it communicates an urgent and potent message about the need for immediate action … it offers insightful reflections on the processes and possibilities of social transformation that undoubtedly will have enduring scholarly and practical value. Dr Katherine Lepani, Social Foundations of Medicine, The Australian National University.
    Keywords: Sociology ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFH Illness & addiction: social aspects
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    Personalized medicine, individual choice and the common good (2022)
    Cambridge University Press
    Details
    Publication Date: 2022-02-11
    Description: law; medicine; medico legal; bioethics and health law; ethics; philosophy
    Keywords: law; medicine; medico legal; bioethics and health law; ethics; philosophy ; bic Book Industry Communication::L Law ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::P Mathematics & science::PS Biology, life sciences::PSA Life sciences: general issues::PSAD Bio-ethics ; bic Book Industry Communication::H Humanities::HP Philosophy
    Language: English
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    Cemeteries Gravemarkers (2023)
    University Press of Colorado | Utah State University Press
    Details
    Publication Date: 2023-10-05
    Description: Cemeteries house the dead, but gravemarkers are fashioned by the living, who record on them not only their pleasures, sorrows, and hopes for an afterlife, but also more than they realize of their history, ethnicity, and culture. Richard Meyer has gathered twelve original essays examining burial grounds through the centuries and across the land to give a broad understanding of the history and cultural values of communities, regions, and American society at large.
    Keywords: Sociology ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFH Popular beliefs & controversial knowledge::JFHF Folklore, myths & legends
    Language: English
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    Blood-Derived Products for Tissue Repair/Regeneration (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-12-21
    Description: This Special Issue on “Blood-Derived Products for Tissue Repair and Regeneration” reveals the evolution and diversity of platelet rich plasma (PRP) technologies, which includes experimental research on novel formulations, the creation of combination therapies, and the exploration of potential modifiers of PRPs, as well as efficacy of PRP therapies in clinical veterinary and human applications. Scientist and clinicians are now starting to develop different treatments based on their reinterpretation of the traditional roles of platelets and plasma, and the current Issue has provided a forum for sharing research and ways of understanding the associated medicinal benefits from different points of view. The research interest in this area has covered different medical disciplines, such as ophthalmology, dentistry, orthopedics, and sports medicine.
    Keywords: R5-920 ; RM1-950 ; n/a ; biomaterial ; redifferentiation ; regenerative medicine ; skeletal muscle regeneration ; furcation defects ; Platelet-Rich Plasma (PRP) ; PRP ; fracture ; fibrin sealant ; periodontal surgery ; bone regeneration ; serum derived from plasma rich in growth factors (s-PRGF) ; cartilage repair ; myofibroblasts ; autologous platelet concentrates ; burns ; satellite cells ; articular cartilage ; stem cell niche ; wound healing ; quantification ; growth factors ; biologics ; platelet rich plasma ; meniscus ; adipose tissue ; Carprofen ; platelet-rich fibrin ; platelets ; hyperacute serum ; bone defects ; serum eye drops ; corneal epithelial defect ; fibrosis ; dog ; myoblasts ; differentiation ; chronic meniscal lesion ; horizontal meniscal tear ; PRGF ; collagen hydrogels ; periodontal defects ; bone grafting material ; composition ; cell therapy ; bone healing ; tissue healing ; trephination ; plasma rich plasma (PRP) ; bone repair ; plasma rich in growth factors ; knee arthrosis ; meniscus tear ; cornea regeneration ; wrist osteoarthritis ; periosteal sheet ; Platelet-Poor Plasma (PPP) ; platelet-rich plasma ; microfat ; bone grafting ; hyaluronic acid (NaHA) ; periodontal regeneration ; meniscus repair ; photobiomodulation therapy ; growth ; myogenesis ; blood derived products ; low-level laser therapy ; bic Book Industry Communication::M Medicine
    Language: English
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    Ventricular Mechanics in Congenital Heart Disease (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Looking at "Horse in Motion", the iconic photograph by E. Muybridge, it is almost possible to hear the horse galloping. The pounding sound of the hoofs hitting the ground -like a drum- can also echo the rythmic beating of the human heart. That sound, that visceral rhythm, reminds us of the link between motion and performance: the perfectly executed stride of the horse, the incredible coordination of multiscale phenomena behind a heart beat. Furthermore, the decomposed sequence in Muybridge's photograph has become a well-known example of breaking motion into its components over time, and as such is reminiscent of those images that are routinely acquired in clinical practice, where the heart appears dilating and shirnking in a sequence of snapshots. The investigation of this motion and its subtleties is essential for refining our understanding of cardiac function, and the appreciation of how and when this motion is no longer perfectly executed can lead us to understand functional impairments and provide insight into the unfolding of pathology. In the presence of congenital heart disease (CHD), cardiac mechanics are altered: from single ventricle physiology to conduction abnormalities to different cardiomyopathies, it is important to both capture and interpret biomechanical changes that occur in the presence of a congenital defect. This special issue in Frontiers in Pediatrics, now an e-book, focuses on 'Ventricular mechanics in congenital heart disease' and looks at current knowledge of phenomena such as systolic/diastolic dysfuction and current methods (chiefly in cardiovascular magnetic resonance imaging and echocardiography) to evaluate cardiac function in the presence of CHD, and then presents a series of original studies that employ both medical imaging and computational modelling techniques to study specific CHD scenarios.
    Keywords: R5-920 ; RJ1-570 ; cardiovascular magnetic resonance imaging ; ventricular mechanics ; Congenital Heart Diseases ; hypoplastic left heart syndrome ; diastolic function ; computational modelling ; systolic function ; haemodynamics ; bic Book Industry Communication::M Medicine
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    Clinical Advances in Chronic Intestinal Diseases Treatment (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-05-06
    Description: Chronic intestinal diseases are increasing around the world. With poor quality of life and expensive healthcare costs, the patients demand novel approaches and treatments for better clinical outcomes. This book illustrates the state of the art and the envisaged near future in the management of these pathologies.
    Keywords: chronic intestinal pseudo-obstruction ; parenteral nutrition ; pediatrics ; myopathy ; neuropathy ; IBS ; microbiota ; visceral hypersensitivity ; colorectal motility ; inflammatory bowel disease ; Crohn’s disease ; ulcerative colitis ; anti-TNF ; ustekinumab ; vedolizumab ; postoperative complications ; surgery ; preoperative therapy ; biologic therapy ; bio-naïve ; IBD ; pro-inflammatory cytokines ; lymphocyte migration ; treatment ; inflammatory bowel diseases ; biologic treatment ; combination ; n/a ; bic Book Industry Communication::M Medicine
    Language: English
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    Assessing Atmospheric Pollution and Its Impacts on the Human Health (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-02-02
    Description: This reprint contains articles published in the Special Issue entitled "Assessing Atmospheric Pollution and Its Impacts on the Human Health" in the journal Atmosphere. The research focuses on the evaluation of atmospheric pollution by statistical methods on the one hand, and on the other hand, on the evaluation of the relationship between the level of pollution and the extent of its effect on the population's health, especially on pulmonary diseases.
    Keywords: household air pollution ; fine particulate matter ; international environmental health ; cookstove ; respiratory disease ; brick worker ; particulate matter ; heavy metals ; Sulfate-Nitrate-Ammonium ; pollution levels ; mobile sources ; aerosols ; PAHs ; OC and EC ; transport sources ; urbanized coastal station ; grain dust ; health risk assessment ; Monte Carlo simulation ; disability adjusted life year ; multi-media exposure ; health risk ; probabilistic risk assessment ; Lake Chaohu ; PM10 ; health risks ; extreme learning machine ; echo state network ; neural networks ; pollution ; concentration ; indicators ; aberrant values ; nitrogen oxides ; ARIMA ; GRNN ; ARIMA–GRNN ; isolation forest ; LOF ; AOD ; classification ; dendrogram ; PCA ; air quality index ; polluting agents ; respiratory diseases ; monitoring stations ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MM Other branches of medicine::MMG Pharmacology::MMGT Medical toxicology
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    Technology in Rehabilitative Interventions for Children (2022)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2022-06-21
    Description: This Special Issue is aimed to offer an overview of studies presenting new rehabilitation approaches addressed to children with neurodevelopmental disorders, designed to enhance the effects of learning processes through the use of new technologies. The contributions of this Special Issue, authored by researchers and clinicians from some of the most valued Italian scientific institutions in the field of neurodevelopmental disorders, can offer some useful data and advice on the use of technology in rehabilitation and telerehabilitation to researchers, rehabilitators, clinicians and pratictioners (psychologists, neuropsychologists, speech therapists, etc.).
    Keywords: neurorehabilitation ; cognitive enhancement in children ; tech mediated rehabilitation ; developmental coordination disorders ; virtual reality ; telerehabilitation ; specific learning disorders ; cerebral palsy ; well-being ; dyslexia ; rhythm ; music therapy ; intervention ; developmental dyslexia ; new technologies ; augmented reality ; good practices ; Delphi method ; rehabilitation ; remote intervention ; children ; age ; severity ; improvement ; follow-up ; n/a ; bic Book Industry Communication::M Medicine
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    Personalized Nursing and Health Care (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-05-11
    Description: There has been a rapid development in the academic literature over the last ten years on papers relating to individualization, personalization, patient-, client-, consumer- and person-centredness, with work on conceptual, instrumental, observational, and experimental levels. This Special Issue presents papers that can further establish the current state of science on these topics relating to personalized nursing and health care. We collected papers that highlight and further the knowledge base conceptually, instrumentally, observationally, and experimentally with sound theoretical and methodological underpinnings and implications for research, theory, and clinical work in the disciplines of nursing, medicine, allied health, and beyond.
    Keywords: anxiety ; life satisfaction ; life–work concerns ; melatonin ; cortisol ; biopsychosocial model ; obstetric complications ; patients’ rights ; student ; nursing ; personalized medicine ; HIV ; mobile health ; smartphone application ; symptom management ; nurse practitioners ; nursing home ; COVID-19 ; palliative care ; end-of-life ; dignified death ; older adults ; accidental falls ; fall prevention ; barriers ; patient compliance ; music therapy ; dementia ; caregiver ; RCT ; patient-centred care ; competence ; assessment ; instrument ; measurement ; validity ; reliability ; individual care ; nurses ; older diabetes patients ; physicians ; support ; Parkinson’s disease ; nursing training ; integrated care ; Parkinson nurse ; personalized care ; multidisciplinary care ; patient-centered ; arthritis ; autoimmune disease ; sociopsychological factors ; emotion ; depression ; self-identity ; qualitative study ; observational study ; dysmenorrhea ; kinesio tape ; auricular acupressure ; pain ; nursing care ; patient care planning ; quality of health care ; conditional inference trees ; education ; distance ; learning ; digital ; drawings ; Nigeria ; perinatal loss ; social networks ; stillbirth ; stillborn ; functional status ; health care ; hospitalization ; activities of daily living ; pelvic floor muscle exercises ; pelvic floor dysfunction ; qualitative research ; therapeutic exercise ; therapeutic adherence ; women’s health physiotherapy ; diabetes mellitus type 2 ; prediction model ; LogicRegression ; interpretability ; pelvic organ prolapse ; lifestyle changes ; women’s experience ; n/a ; foot ; foot self-care ; methodological review ; bic Book Industry Communication::M Medicine
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    Innovative Pasta with High Nutritional and Health Potential (2023)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2023-03-07
    Description: Dry pasta is one of the most popular staple foods worldwide due to its convenience in terms of affordability, versatility, long shelf life, as well as sensory and nutritional value. As such, it represents a suitable carrier for health-promoting substances providing specific physiological functions. This Special Issue deals with the continuum aspects, “from seed to fork”, that could have an impact on the nutritional, sensory, and technological aspects of pasta. In this Special Issue, we aimed to publish innovative research and review papers on physico-chemical and sensorial characteristics, nutritional value, functional and technological properties of pasta, and pasta-making processes. New raw materials, new functional ingredients, up-cycling of waste materials, in vivo experiments to test the effect of assumption of the supplemented pasta, and innovative packaging systems will also be addressed in this Special Issue. Predictions of pasta quality adopting chemometrics as well as multi-variate and statistical data analysis approaches were welcomed. Finally, in the medium term, the international pasta market is expected to stay negative unless tangible product innovations are introduced, particularly regarding the technological innovations aimed at improving the products’ health benefits. This Special Issue aimed to provide a fundamental understanding and present the current strategies to improve the technological, nutritional, and sensory properties of pasta.
    Keywords: innovative pasta raw materials ; durum ; emmer ; spelt ; pasta ; brewers’ spent grain ; dietary fiber ; einkorn ; functional pasta ; tritordeum ; upcycling ; unconventional ingredients ; nutritional value ; cooking quality ; legumes ; Spirulina Platensis ; resistant starch ; hydrolysis index ; dietary fibre ; annealing ; slowly digestible starch ; carbohydrates ; fiber ; in vitro digestion ; micronization ; brown rice ; air fractionation ; parboiling ; rice pasta ; enriched pasta ; bioactive compound ; tuna ; sea bass ; Ω-3 fatty acids ; sensometrics ; TPA (texture profile analysis) ; glycemic index ; glycemic response ; durum wheat ; landraces ; starch ; available carbohydrates ; glycemic load ; texture profile analysis ; gluten-free ; celiac disease ; fish ; allergy ; pear, date, and apple by-products ; wheat flour ; sensorial properties ; scanning electron microscopy ; multiple factor analysis ; n/a ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBP Health systems & services::MBPK Mental health services
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    Self-Reported Population Health: An International Perspective based on EQ-5D (2021)
    Springer Nature
    Details
    Publication Date: 2023-01-13
    Description: Biomedicine general; Public Health; Quality of Life Research; Population Health; EQ-5D; Quality-of-Life; Utilities
    Keywords: Biomedicine general ; Public Health ; Quality of Life Research ; Population Health ; EQ-5D ; Quality-of-Life ; Utilities ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KND Manufacturing industries::KNDP Pharmaceutical industries ; bic Book Industry Communication::M Medicine ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine ; bic Book Industry Communication::T Technology, engineering, agriculture::TC Biochemical engineering
    Language: English
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    The Good Drone (2022)
    The MIT Press | The MIT Press
    Details
    Publication Date: 2022-02-21
    Description: How small-scale drones, satellites, kites, and balloons are used by social movements for the greater good. Drones are famous for doing bad things: weaponized, they implement remote-control war; used for surveillance, they threaten civil liberties and violate privacy. In The Good Drone, Austin Choi-Fitzpatrick examines a different range of uses: the deployment of drones for the greater good. Choi-Fitzpatrick analyzes the way small-scale drones—as well as satellites, kites, and balloons—are used for a great many things, including documenting human rights abuses, estimating demonstration crowd size, supporting anti-poaching advocacy, and advancing climate change research. In fact, he finds, small drones are used disproportionately for good; nonviolent prosocial uses predominate. Choi-Fitzpatrick's broader point is that the use of technology by social movements goes beyond social media—and began before social media. From the barricades in Les Misérables to hacking attacks on corporate servers to the spread of #MeToo on Twitter, technology is used to raise awareness, but is also crucial in raising the cost of the status quo. New technology in the air changes politics on the ground, and raises provocative questions along the way. What is the nature and future of the camera, when it is taken out of human hands? How will our ideas about privacy evolve when the altitude of a penthouse suite no longer guarantees it? Working at the leading edge of an emerging technology, Choi-Fitzpatrick takes a broad view, suggesting social change efforts rely on technology in new and unexpected ways.
    Keywords: Impact of science and technology on society ; Sociology ; Warfare and defence ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBK Sociology: family & relationships::JHBK5 Sociology: sexual relations ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::P Mathematics & science::PD Science: general issues::PDR Impact of science & technology on society
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    Standards-Based Accountability Under No Child Left Behind (2023)
    RAND Corporation
    Details
    Publication Date: 2023-10-05
    Description: Since 2001-2002, standards-based accountability provisions of the No Child Left Behind Act of 2001 have shaped the work of public school teachers and administrators in the United States. This book sheds light on how accountability policies have been translated into actions at the district, school, and classroom levels in three states.
    Keywords: Sociology ; Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSP Age groups::JFSP1 Age groups: children
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    Natural Antibodies in Health and Disease (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.
    Keywords: R5-920 ; RC581-607 ; innate immunity ; immunoglobulin ; Antibodies ; B cells ; IgM ; natural antibodies ; B-1 cells ; bic Book Industry Communication::M Medicine
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    Dimensions of Locality (2021)
    transcript Verlag
    Details
    Publication Date: 2024-03-24
    Description: As a world religion Islam is based on a highly abstract and absolute notion of the transcendent, which its followers establish and celebrate - in a seemingly contradictory fashion - at very specific sites: Mecca, Medina, Jerusalem, and the vast and complex landscapes of mosques and Muslim saints' shrines around the world. Sacred locality has thus become a paradigm for the relationship between the human and the transcendent, a model for urban planning, regional networks, imaginary spaces, and spiritual hierarchies alike. This importance of saintly places has, however, become increasingly complicated and troubled by reformist currents within Islam, on the one hand, and the emergence of modern archeology and anthropology, on the other. While they have often tended to posit 'the local' in opposition to 'the universal', in this volume islamologists, anthropologists, and sociologists offer new ways of thinking about the local, the place, and the conceptual landscapes and spaces of saints. In this, its eighth volume, the Yearbook for the Sociology of Islam looks at different sites and regions around the Muslim world (notably Burkina Faso, Egypt, Ethiopia, and Southeast Asia) not as 'localized' versions of a universal Islam, but as constitutive of one particular outlook of the universalizing order of a world religion.
    Keywords: Modern Islam ; Islamic Shrines ; Egypt ; Ethiopia ; South-East Asia ; Burkina Faso ; Islam ; Space ; Islamic Studies ; Sociology of Religion ; Religious Studies ; Sociology ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRP Islam
    Language: English
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    Homeostasis and Allostasis of Thyroid Function (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: The discovery of the negative feedback of thyroid hormones on pituitary thyroid-stimulating hormone (TSH) secretion, a classical endocrine feedback control system, has shaped diagnosis and treatment of thyroid disease for the last decades. Based on this concept, a unique diagnostic category of subclinical thyroid disorders was introduced, being defined exclusively by an abnormal TSH response in the presence of thyroid hormone concentrations within the reference range. Although this approach was able to deliver a conceptually straightforward disease definition problems surfaced in clinical practice as neither the diagnostic reference range nor the appropriate threshold for initiating substitution treatment are universally agreed upon for subclinical thyroid disorders. The situation is further aggravated by the so-called syndrome T, which comprises a substantial but heterogeneous group of L-T4 treated patients with hypothyroidism with reduced quality of life despite “normal” TSH values.〈/p〉〈p〉A limited understanding of the physiological relationships between TSH and thyroid hormones may be a main reason for clinical difficulties in dealing with the causes of syndrome T and tailoring substitution therapy for hypothyroid patients with subclinical thyroid disorders. 〈/p〉〈p〉Feedback regulation has recently been shown to be much more complex than previously assumed. The concept of homeostatic control has also been extended to include the lesser known but equally important allostatic thyroid regulation.The latter aims at adaptive homeostasis or stability through changing setpoints and modulating structural parameters of feedback control, as may be appropriate to adapt to a vast array of conditions spanning from fetal life, aging, pregnancy, exercise, starvation, obesity, psychiatric disorders to the severe non-thyroidal illness syndrome.〈/p〉〈p〉A better understanding of homeostatic and allostatic mechanisms, which govern the behaviour of pituitary-thyroid feedback control, is on the horizon. This promises to improve the diagnostic utility of laboratory methods, laying the foundation for personalised methods to optimise dosage and modality of substitution therapy. The emerging new world of thyroid physiology is reflected on the side of clinical medicine in a new, relational paradigm for diagnosis and treatment.〈/p〉〈p〉Considerable progress has been made in this respect in the following key areas:〈/p〉〈p〉• the significance of complementary information processing structures within the feedback loop, in particular ultrashort feedback of TSH on its own secretion and the action of a TSH-T3 shunt unburdening the thyroid from T4 synthesis in imminent thyroid failure,〈/p〉〈p〉• the unravelling of spatio-temporal dynamics of hormone concentrations ranging from ultradian to circannual rhythms and including hysteresis effects,〈/p〉〈p〉• the emergence of “non-canonical” mechanisms of thyroid hormone signalling beyond transcriptional control of gene expression,〈/p〉〈p〉• the physiological actions of thyronine metabolites, which have been previously regarded as biologically inactive, such as thyronamines and iodothyroacetates,〈/p〉〈p〉• the characterisation of distinct patterns in the adaptive processes to stress and strain and their conclusive explanation through reactions to type 1 and type 2 allostatic load.〈/p〉〈p〉This collective volume contains the contributions to the Research Topic “Homeostasis and Allostasis of Thyroid Function”, which was originally published by the journal Frontiers in Endocrinology. Authored by an international team of experts from three continents ,the book provides a comprehensive overview on thyroid control from recent research in basic, computational and clinical thyroidology. Many aspects addressed here can be expected to stimulate future research. A more comprehensive view and better integration of in-vitro, in-silico and in-vivo investigations will be invaluable in paving the way to this new world of thyroidology.
    Keywords: R5-920 ; RC648-665 ; relational stability ; Thyronamines ; TSH-T3 Shunt ; thyroid allostasis ; precision medicine ; Stratified Medicine ; 3-T1AM ; Hypothyroidism ; Thyroid homeostasis ; Hysteresis ; bic Book Industry Communication::M Medicine
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    New treatment perspectives in autism spectrum disorders (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-21
    Description: Developing novel and more effective treatments that improve quality of life for individuals with autism spectrum disorders is urgently needed. To date a wide range of behavioral interventions have been shown to be safe and effective for improving language and cognition and adaptive behavior in children and adolescents with ASD. However many people with ASD can receive additional benefit from targeted pharmacological interventions. One of the major drawback in setting up therapeutics intervention is the remarkable individual differences found across individuals with ASD. As a matter of fact the medications that are currently available address only symptoms associated with ASD and not the core domains of social and communication dysfunction. The pathogenesis paradigm shift of ASD towards synaptic abnormalities moved the research to pathway to disease that involve multiple systems and that are becoming the forefront of ASD treatment and are pointing toward the development of new targeted treatments. Some new therapeutics have been tested and others are being studied. In this context single gene disorders frequently associated with ASD such as Rett Syndrome, Fragile X and Tuberous Sclerosis have been of significant aid as neurobiology of these disorders is more clear and has a potential to shed light on the altered signaling in ASD. However much research is needed to further understand the basic mechanisms of disease and the relationship to idiopathic ASD. Clinical trials in children are underway with agents directed to core symptoms and to the associated disorders in the search of new therapeutics and progress are expected with possible new option for therapeutics in ASD in the upcoming future. Children and Adolescents with ASD and their families can provide important information about their experience with new treatments and this should be a priority for future research. In addition, research performed on genetic mouse models of ASD will keep on providing useful information on the molecular pathways disrupted in the disease, thus contributing to identify novel drug targets.
    Keywords: R5-920 ; RJ1-570 ; Clinical Trial ; mouse model ; neurodevelopmental disorder ; Genetics ; autism ; bic Book Industry Communication::M Medicine
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