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  • Q1-390  (1,523)
  • bic Book Industry Communication::J Society & social sciences::JP Politics & government  (715)
  • English  (2,187)
  • Portuguese  (52)
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  • 11
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    Role of DNA Methyltransferases in the Epigenome (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: DNA methylation, a modification found in most species, regulates chromatin functions in conjunction with other epigenome modifications, such as histone post-translational modifications and non-coding RNAs. In mammals, DNA methylation has an essential role in development by orchestrating the generation and maintenance of the phenotypic diversity of human cell types. Recent years have brought spectacular advances in our understanding of the mechanism, function and regulation of DNA methyltransferases through their interaction with other epigenome modifications, chromatin factors and post-translational modifications, which are described in this Special Issue of Genes. Manuscripts are specifically addressing describing the targeting and regulation of DNA methyltransferases by interacting factors and their roles in cellular differentiation and the development of diseases. Prof. Dr. Albert Jeltsch and Prof. Dr. Humaira Gowher, Guest Editors
    Keywords: QH301-705.5 ; Q1-390 ; DNMTs ; n/a ; histone modification ; TBRS ; DNA methyltransferases ; autoinhibition ; epigenetics ; DNMT ; cell identity ; embryogenesis ; dwarfism ; DNMT3B ; germ cells ; HSAN1E ; USP7 ; DNMT3A ; DNA methyltransferase ; gene expression ; DNMT1 ; de novo DNA methylation ; DNA methyltransferase structure ; UHRF1 ; DNA methyltransferase mechanism ; allosteric regulation ; rare diseases ; DNA Methylation ; maintenance DNA methylation ; DNA methylation ; ADCA-DN ; PCC/PGL ; ubiquitination ; TETs ; DNA methyltransferase function ; molecular epigenetics ; DNA methyltransferase regulation ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences
    Language: English
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  • 12
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    Genome-wide view on the physiology of vitamin D (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-03-31
    Description: The main physiological actions of the biologically most active metabolite of vitamin D, 1a,25-dihydroxyvitamin D3(1a,25(OH)2D3), are calcium and phosphorus uptake and transport and thereby controlling bone formation. Other emergent areas of 1a,25(OH)2D3 action are in the control of immune functions, cellular growth and differentiation. This fits both with the widespread expression of the VDR and the above described consequences of vitamin D deficiency. Transcriptome-wide analysis indicated that per cell type between 200 and 600 genes are primary targets of vitamin D. Since most of these genes respond to vitamin D in a cell-specific fashion, the total number of vitamin D targets in the human genome is far higher than 1,000. This is supported by the genome-wide view on VDR binding sites in human lymphocytes, monocytes, colon and hepatic cells. All genomic actions of 1a,25(OH)2D3 are mediated by the transcription factor vitamin D receptor (VDR) that has been the subject of intense study since the 1980’s. Thus, vitamin D signaling primarily implies the molecular actions of the VDR. In this research topic, we present in 15 chapters different perspectives on the action of vitamin D and its receptor, such as the impact of the genomewide distribution of VDR binding loci, ii) the transcriptome- and proteome-wide effects of vitamin D, iii) the role of vitamin D in health, iv) tissue-specific functions of vitamin D and v) the involvement of vitamin D in different diseases, such as infections, autoimmune diseases, diabetes and different types of cancer.
    Keywords: QP1-981 ; Q1-390 ; Vitamin D ; Immune System ; Genomics ; vitamin D receptor ; Physiology ; thema EDItEUR::M Medicine and Nursing::MF Pre-clinical medicine: basic sciences::MFG Physiology
    Language: English
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  • 13
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    Equity Policies in Global Higher Education (2022)
    Springer Nature | Palgrave Macmillan
    Details
    Publication Date: 2022-03-16
    Description: This book discusses and analyses global policies and practices aimed at promoting equity in higher education participation and attainment. Although the massification of higher education systems has facilitated the participation of students from deprived backgrounds, socioeconomic inequalities persist in access to the most prestigious institutions and programmes. Privileged students benefit from a number of advantages in the competition for selective and scarce places: access to information, lower aversion to debt, higher expectations, better previous schooling and higher academic achievement. The chapters present a critical analysis of equity policies in different countries – with or without affirmative action policies, within a context of neoliberal policies or within a social democratic model – and the reasons why they have failed to promote equity and fairness, preventing students from achieving their full educational potential. This is an open access book.
    Keywords: equity in higher education ; access to higher education ; participation in higher education ; attainment and retention ; higher education policy ; Open Access ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 14
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    Geoturismo e interpretação ambiental (2021)
    SciELO Books - Editora UEPG
    Details
    Publication Date: 2023-12-20
    Description: Dividido em três partes, este livro enfoca o turismo em áreas naurais, destacando o geoturismo, abrange aspectos ligados à geoconservação em áreas protegidas e os Geoparques e por fim aborda a educação e interpretação ambiental, incluindo diversos exemplos de atividades geoeducativas, interpretativas e turísticas.
    Keywords: Q1-390 ; SCIENCE ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: Portuguese
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  • 15
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    The Role of Glia in Plasticity and Behavior (2021)
    Frontiers Media SA
    Details
    Publication Date: 2024-04-05
    Description: Glial cells are no longer considered passive bystanders in neuronal brain circuits. Not only are they required for housekeeping and brain metabolism, they are active participants in regulating the physiological function and plasticity of brain circuits and the online control of behavior both in invertebrate and vertebrate model systems. In invertebrates, glial cells are essential for normal function of sensory organs (C. elegans) and necessary for the circadian regulation of locomotor activity (D. melanogaster). In the mamallian brain, astrocytes are implicated in the regulation of cortical brain rhythms and sleep homeostasis. Disruption of AMPA receptor function in a subset of glial cell types in mice shows behavioral deficits. Furthermore, genetic disruption of glial cell function can directly control behavioral output. Regulation of ionic gradients by glia can underlie bistability of neurons and can modulate the fidelity of synaptic transmission. Grafting of human glial progenitor cells in mouse forebrain results in human glial chimeric mice with enhanced plasticity and improved behavioral performance, suggesting that astrocytes have evolved to cope with information processing in more complex brains. Taken together, current evidence is strongly suggestive that glial cells are essential contributors to information processing in the brain. This Research Topic compiles recent research that shows how the molecular mechanisms underlying glial cell function can be dissected, reviews their impact on plasticity and behavior across species and presents novel approaches to further probe their function.
    Keywords: RC321-571 ; Q1-390 ; Cerebellum ; C. elegans ; Astrocytes ; DREADD ; Cortex ; plasticity ; Gq ; Behavior ; glia ; Hippocampus ; thema EDItEUR::P Mathematics and Science::PS Biology, life sciences::PSA Life sciences: general issues::PSAN Neurosciences
    Language: English
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  • 16
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    The Last Mile (2023)
    Taylor & Francis | Routledge India
    Details
    Publication Date: 2024-01-30
    Description: The Last Mile explores the gaps and dichotomy between drafted policies and their implementation, and the last mile challenges which often make public services inaccessible to the poorest and most vulnerable sections of society. It provides an in-depth overview of the dynamics between communities, research and consultation and the implementation of policies for development. Rich in empirical data and case studies from different government programmes and reports, this book examines the implementation of government service programmes for poverty reduction, women’s empowerment, and income generation for the poor, among others, from a people’s perspective. It highlights the need for policies and institutions to align their methods to community needs. Offering guidelines for redesigning as well as solutions to counter challenges related to lack of trust and effective communication, human resource management, capacity development, redressal mechanisms, and facilitating the last mile connection, the author delineates effective ways for integrating new technologies in policy implementation. The book also addresses legacy issues in institutions and re-orienting policy for better governance, transparency, and building trust. Part of the Innovations, Practice and the Future of Public Policy in India series, this book, by a senior practitioner, will be an essential resource for students and researchers of development studies, sociology, public policy and governance, economics, and South Asian studies. This book is freely available as a downloadable Open Access PDF at http://www.taylorfrancis.com under a Creative Commons (CC-BY-NC-ND) 4.0 license.
    Keywords: community development ; governance ; public policy ; social programmes ; socioeconomic development ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKS Social welfare & social services ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCM Development economics & emerging economies ; bic Book Industry Communication::K Economics, finance, business & management::KJ Business & management ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSF Rural communities ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTB Regional studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general
    Language: English
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  • 17
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    Chapter 35 The extraterritorial application of international human rights law on civil and political rights (2021)
    Taylor & Francis | Routledge
    Details
    Publication Date: 2023-09-12
    Description: The Routledge Handbook of International Human Rights Law provides the definitive global survey of the discipline of international human rights law. Each chapter is written by a leading expert and provides a contemporary overview of a significant area within the field. As well as covering topics integral to the theory and practice of international human rights law the volume offers a broader perspective though examinations of the ways in which human rights law interacts with other legal regimes and other international institutions, and by addressing the current and future challenges facing human rights. Providing up-to-date and authoritative articles covering key aspects of international human rights law, this book work is an essential work of reference for scholars, practitioners and students alike. Chapter 35 of this book is freely available as a downloadable Open Access PDF under a Creative Commons Attribution-Non Commercial-No Derivatives 3.0 license. https://www.routledgehandbooks.com/doi/10.4324/9780203481417.ch35
    Keywords: books by Nigel Rodley ; counter-terrorism and human rights ; economic, social and cultural rights ; human rights enforcement ; International criminal law and human rights ; International trade and human rights ; international human rights ; international human rights law ; investment and human rights ; Nigel Rodley ; non-State actors and human rights ; UN and human rights ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics
    Language: English
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  • 18
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    Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies (2021)
    MDPI - Multidisciplinary Digital Publishing Institute
    Details
    Publication Date: 2024-04-05
    Description: Newborn Screening for Sickle Cell Disease and other Haemoglobinopathies is a Special Issue of the International Journal of Neonatal Screening. Sickle cell disease is one of the most common inherited blood disorders, with a huge impact on health care systems due to high morbidity and high mortality associated with the undiagnosed disease. Newborn screening helps to make the diagnosis early and to prevent fatal complications and diagnostic odysseys. This book gives an overview of diagnostic standards in newborn screening for sickle cell disease and examples of existing newborn screening programs.
    Keywords: QD1-999 ; Q1-390 ; glucose-6-phosphate dehydrogenase ; hydroxyurea/hydroxycarbamide ; n/a ; cord blood ; screening ; hemoglobin pattern ; capillary electrophoresis ; sickle cell disease ; (recommended) screening panel ; vaso-occlusive crisis ; Guthrie spots ; newborn screening) ; foetal haemoglobin ; harmonisation ; review ; birth prevalence ; G6PD deficiency ; prevention ; end-organ damage ; thalassemia ; MALDI-TOF ; IEF ; acute chest syndrome ; India ; sickle cell and thalassaemia screening programme ; ‘Getting to Outcomes’ ; newborn screening ; hemoglobinopathy ; service users ; public health engagement ; automated HPLC ; Kaduna State ; gene therapy for haemoglobinopathies ; ?-globin gene ; methods ; neonatal screening program ; malaria ; Plasmodium vivax ; sub-Saharan Africa ; patient organisations ; health policy ; pathophysiology ; Sickle Cell Disease ; mass spectrometry ; sickle cell disorder ; neonatal screening ; non-tribal ; Nigeria ; point-of-care ; HPLC ; laboratory methods ; registry ; patient advocacy ; bone marrow transplant ; anaemia ; hemoglobinopathies ; tribal ; newborn ; burden of disease ; patient representatives ; diagnostics ; policy making ; haemolysis ; Caribbean ; high performance liquid chromatography (HPLC) ; sickle cell disease (SCD) ; implementation science ; thema EDItEUR::P Mathematics and Science::PN Chemistry
    Language: English
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  • 19
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    Chapter 8 Unintended Consequences of EU Democracy Support in the European Neighbourhood (2019)
    Taylor & Francis | Unintended Consequences of EU External Action | Routledge
    Details
    Publication Date: 2023-09-12
    Description: "The European Union’s (EU) impact on the political governance of the European neighbourhood is varied and sometimes opposite to the declared objectives of its democracy support policies. The democracy promotion literature has to a large extent neglected the unintended consequences of EU democracy support in Eastern Europe and the Middle East and North Africa. The EU has left multiple imprints on the political trajectories of the countries in the neighbourhood and yet the dominant explanation, highlighting the EU’s security and economic interests in the two regions, cannot fully account for the unintended consequences of its policies. The literature on the ‘pathologies’ of international organisations offers an explanation, emphasizing the failures of the EU bureaucracy to anticipate, prevent or reverse the undesired effects of its democracy support in the neighbourhood."
    Keywords: Democracy promotion ; ENP ; unintended consequence ; bureaucracy ; Eastern Europe ; MENA ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 20
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    A Continent Moving West? (2023)
    Amsterdam University Press
    Details
    Publication Date: 2024-03-29
    Description: A Continent Moving West? argues that the conceptualization of migration as a one-way or long-term process is becoming increasingly wide of the mark. Rather, east-west labor migration in Europe, in common perhaps with other flows in and from other parts of the world, is diverse, fluid, and influenced by the dynamics of local and sector-specific labor markets and migration-related political regulations. The papers in this book contribute to critical understanding of the east-west migration within the European Union after the 2004 enlargement, from the new to the old member states.
    Keywords: Sociology ; Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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