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  • bic Book Industry Communication::J Society & social sciences::JP Politics & government  (157)
  • RC581-607  (126)
  • thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
  • Frontiers Media SA  (150)
  • Springer Nature  (94)
  • ANU Press  (71)
  • Bloomsbury Academic  (9)
  • English  (324)
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  • English  (324)
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  • German  (15)
Years
  • 1
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-14
    Description: This open access book by Nils Karlson explores the strategies used by left- and right-wing populists to make populism intelligible, recognizable, and contestable. It presents a synthesized explanatory model for how populists promote autocratization through the deliberate polarization of society. It traces the ideational roots of the core populist ideas and shows that these ideas form a collectivistic identity politics. Karlson argues that to fight back requires the revival of liberalism itself by defending and developing the liberal institutions, the liberal spirit, liberal narratives, and liberal statecraft.  The book also presents and discusses an extensive list of counterstrategies against populism.  Written within the tradition of political theory and institutional economics, this book uses a wide variety of sources, including results and analyses from social psychology, ethics, law, and history.
    Keywords: Classical Liberalism ; Populism ; Liberalism ; Liberal ; statecraft ; liberal politics ; identity politics ; political theory ; institutional economics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 2
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-14
    Description: This open access book uncovers the historical context and entrenched beliefs that have perpetuated exclusionary urban landscapes and disadvantage for marginalized groups. It offers an in-depth exploration of the intricate interplay of geographical space, recognizing its pivotal role in shaping our cities and exacerbating spatial injustice. The construction industry, a vital agent in forging accessible environments, often falls short in accommodating persons with disabilities and older individuals. This important book underscores the urgent need for integrated approaches woven into the fabric of cities, companies, and the construction industry itself, to ensure universal accessibility. Drawing upon practical strategies and compelling case studies, the book presents actionable frameworks such as the DisCo Policy Framework and the Iceberg of Inequality Model, facilitating the assessment of progress towards achieving radical inclusion. Inviting readers to embark on a journey into the cities of tomorrow, where inclusion and belonging are the norm, it concludes with a simple idea: the future is accessible.
    Keywords: Urban Studies ; Urban Affairs ; Urban Governance ; Disability Studies ; Urbanization ; Public Administration ; Sociology ; Development Studies ; Public Policy ; Smart Cities ; Inclusive Design ; Capability Based Planning ; Universal Design ; Environmental Design ; Urban Planning ; Covid-19 ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography
    Language: English
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  • 3
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This open access book is intended as an original contribution to the conversation on the role and challenges of education in Central Asia to promote social cohesion by looking at Kazakhstan, Tajikistan and Uzbekistan. Examining education challenges within the countries’ wider historical, social, political, and cultural context, the contributions explore existing discourses concerning national identity, religion, language, gender, inclusion, internationalisation of education, and non-state actors through a Political Economy Analysis (PEA) lens. With the understanding that education is both a powerful mechanism of social reproduction in societies and a driver of social change, the book attempts to promote political economy analysis of education as a helpful analytical tool for educational debates and reform agendas in the region and thus will be a valuable resource for policymakers, practitioners, and scholars in this region and beyond.
    Keywords: Political Economy Analysis ; Central Asia, Education ; Gender ; Religion ; National Identity ; Language policy ; Internationalisation of Education ; Inclusion ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: English
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  • 4
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-07
    Description: This open access book is the first to provide an analysis of the Dutch paper industry over a period encompassing six centuries. Responding to a trend of renewed scholarly interest in paper industries and production, the book seeks to illuminate the factors behind this relatively small national industry’s centuries-long survival. Previous historical research has shown that sets of colonial, trade, merchant and family networks, tightly interwoven through a dense web of capital, were crucial for paper production and trade in early modern Europe. This book situates the Dutch paper industry within these overlapping contexts and their shifting dynamics over time, and historicizes the challenges and obstacles it had to overcome through four phases of capitalism: the rise of Dutch capitalism (1580–1815), Dutch monarchic liberalism (1815–1914), Fordism (1914–1980), and post-Fordism (1980 until now). Each chapter covers not only technological advancements in the industry, but its development alongside further determining dimensions, such as state-industry relations (industry policies), labour-capital relations (unions) and competition and cooperation, overall painting a picture of how the industry adapted to and endured changes in national and global networks surrounding the industry. This book will be of broad interest to scholars of economic and business history, as well as industrial history, political economy, and management studies.
    Keywords: Dutch paper industry ; paper ; mechanic papermaking ; technological innovation ; Dutch business history ; natural resources ; pulp and paper industry ; raw materials for paper industry ; groundwood ; Dutch 'golden age' ; phases of capitalism ; industry survival ; industrialization ; Post-Fordism ; deregulation ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCZ Economic history ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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  • 5
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    ANU Press | ANU Press
    Publication Date: 2024-03-29
    Description: Nations appear and fall, but cities endure and rediscover how to succeed. In this meticulously defined and researched book, Glenn presents ideas for minimising suffering during urban catastrophes. His urgency identifies risks held in urban areas by 3.5 billion people. These people are many of us: as urban populations occupying 3 per cent of our planet's land area, drawing water from 41 per cent of the world’s ground surface, consuming 60 to 80 per cent of global energy and achieving 80 per cent of the world’s economic productivity. For Glenn, our resilience—through diversity in preparation, survival and recovery—includes comprehensive approaches that are sustained in duration, orchestrated in bringing all necessary capabilities to bear, layered in approach and early in application.’ —Major General Chris Field, Australian Army ‘The time to prepare for the inevitable is now. Dr Glenn has written a book that should be read by all leaders, planners and responders who may be called upon in an urban disaster, whether natural or man-made. Military leaders should give it particular attention, as the human race is increasingly concentrated in its cities. Understanding how to wage war in dense urban terrain is essential, especially if a nation also seeks to hold the moral high ground. The fruits of any victory won among people that fails to consider the lessons in Come Hell or High Fever are likely to be very bitter.’ —Lieutenant General Sean MacFarland, United States Army (retired)
    Keywords: Urban ; Disaster ; HADR ; Humanitarian ; Relief ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JW Warfare & defence ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RP Regional & area planning ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JW Warfare and defence ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RP Regional and area planning
    Language: English
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  • 6
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    Springer Nature | Springer Nature Switzerland
    Publication Date: 2024-03-29
    Description: This open access book explores some of the struggles and challenges that researchers and practitioners face when conducting research in the Central Asian research setting. Written for scholars still in the planning stages of their research, it addresses key questions, including: How shall we problematize and reconceptualize the concept of positionality through lenses of local voices from the region? How does practitioners’ and scholars’ positionality contribute to their experiences of inclusion, exclusion, and access to the field? How do scholars navigate issues of personal safety and mental well-being in the more closely monitored societies of Central Asia? The book includes contributors from both Central Asia and Western countries, paying particular attention to the ways researchers’ subjectivity shape how they are received in the region, which, in turn, influences how they write about and disseminate their research. In featuring an even greater variety of voices, this book fills an important gap in the literature on field research and knowledge production in and on Central Asia.
    Keywords: Central Asia ; Field Research ; Decolonization ; Positionality ; Reflexivity ; Researcher’s ethnicity ; Central Asia Barometer ; Kazakhstan ; Tajikistan ; Research in Central Asia ; Post-Soviet Societies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHM Anthropology::JHMC Social & cultural anthropology, ethnography ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHM Anthropology::JHMC Social and cultural anthropology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 7
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    Springer Nature | Springer Nature Singapore
    Publication Date: 2023-03-20
    Description: This Open Access book provides a comprehensive analysis of political reforms in Japan since the 1990s, emphasizing the role of ideas in shaping their goals and outcomes. For more than fifteen years following the collapse of Japan’s economic bubble, politicians, business people and academics tackled a range of institutional reforms. The sweeping changes they enacted—covering almost all facets of the public sphere, including elections, public administration, courts and the central bank—fundamentally altered Japanese political processes and policies. Taken together, they arguably represent the final touches of Japan’s political modernization, which had been unfolding since the mid-19th century. Throughout the reform process, advocates were inspired by a combination of liberal and modernist ideas. This book examines those guiding concepts and illustrates the often messy process of applying them to real-world institutions. While most reforms began from common goals, they ultimately produced different—and frequently unexpected—institutional outcomes, which continue to shape Japanese politics. By focusing on the relationship between the ideas and processes that shaped Japan’s reforms, this book presents a broad vision of institutional change in comparative politics.
    Keywords: Post-War Japan ; Bubble Economy ; Single-seat constituency ; Proportional representation ; Japan's Lower House ; Japan's Upper House ; Liberal Democratic Party (LDP) ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes::JPHL Political leaders & leadership ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes::JPHF Elections & referenda ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history
    Language: English
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  • 8
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This is an open access book. With the unprovoked Russian invasion of Ukraine, European security has been put on high alert. The implications of the Russian military invasion are many and difficult to grasp in full. However, the need for greater European strategic autonomy appears increasingly evident. The book argues that strategic autonomy may be reached—also in the short run—if differentiated integration is seen as an asset rather than a challenge. While the EU (together with NATO) remains the core in such a system, there is a multitude sub-regional integration processes that need to be taken into account to get the full idea of how European strategic autonomy can be achieved.
    Keywords: European Union Politics ; Actorness ; Differentiated Integration ; Strategic Autonomy ; EU Security Policy ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPP Public administration ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations
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  • 9
    Publication Date: 2023-11-16
    Description: This open access book explores the intersection of property law, relocation, and resettlement processes in the United States and among communities that grapple with migration as an adaptation strategy. As communities face the prospect of relocating because of rising seas, policy makers, disaster specialists, and community leaders are scrambling to understand what adaptation pathways are legally possible. While in its ideal application, law functions blindly and without variation, the authors find that legal contradictions come to bear on resettlement processes and place certain communities further in harm’s way. This book will unearth these contradictions in order to understand why successful community-based resettlement has presented such a challenge to communities that are experiencing increasing land deterioration as a result of climate change.
    Keywords: Environmental politics ; Property Law ; Migration ; United States ; Relocation ; Resettlement ; Climate Change ; Climate justice ; Adaptation ; Climate disaster ; Community-based resettlement ; Land deterioration ; Policy ; Emergency management ; Public administration ; Disaster ; Emergencies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues::LAF Systems of law::LAFD Civil codes / Civil law ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 10
    Publication Date: 2024-03-29
    Description: This open access book examines security and protection within Israel and Palestine, analyzing national and international security strategies that apply to the protection of civilians. The author examines the principles, practices and the perception of protection. Focusing on protection strategies and practices in the Israeli-Palestinian conflict, this book reveals some of the myths and enigmas of national and international protection of civilians. The book moves beyond the current lack of protection strategies to discuss more effective human security focused on prioritizing protection of civilians, use of alternative tools such as community policing and inclusive protection.
    Keywords: Israel ; Palestine ; Middle East ; International Protection ; National Protection ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
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  • 11
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    Springer Nature | Springer Nature Singapore
    Publication Date: 2023-04-18
    Description: This open access book, comprising thirty-nine chapters divided into social, cultural, economic, and political spheres, offers a unique opportunity to dive into the complex, dynamic, and sometimes contradictory transformation of Gulf societies in the last few decades. Whilst the Gulf region has at times been seen as impervious to this natural phenomenon of transformation—timeless, never changing, deeply rooted in its ancient tribal customs and traditions and able to blend past and present seamlessly without suffering the wrenching trauma of change—this is clearly not the case, and the region is not immune to the inevitable forces of social change. There is no doubt today that the social change sweeping the Gulf has been profound, affecting almost every aspect of life in the Gulf societies. This volume has an encyclopedic value as the chapters collectively offer multifaceted and multidisciplinary perspectives to understand social change in the Gulf region. Through these chapters, the role of economic and educational transformation, and the impact of social media, migration, and urbanization have in driving social change in the Gulf societies is examined in detail with a focus on their directions, magnitudes, and relevant policy options. It also considers how COVID-19 is affecting the lives of the people in the Gulf. This book bridges gaps in the understanding of the rapid pace of social change in the Gulf, offering practical solutions for policy interventions. It is of interest to scholars and students in Middle Eastern studies, specifically, as well as sociology, media studies, migration studies, and educational policy. ; This book focuses on the role of economic transformation, education, social media, migration, and urbanization in engaging social change in the Gulf societies, with a focus on their directions, magnitudes, and relevant policy options. It also takes into account how COVID-19 is affecting the lives of the people in the Gulf. Over the last few decades, the Gulf countries have undergone profound social change - generally understood as changes in human interactions and relationships that transform cultural and social institutions - affecting almost every aspect of life in GCC societies. The volume considers how the Gulf countries have achieved success in the education sector, and also examine the changes in conservative attitudes towards female education, as the enrolment of women in higher education is increasing steadily across the Gulf. It also unpacks the social impact of technology, as satellite television and the Internet have dramatically expanded exposure to outside views. Access to social media has similarly proved a powerful force for social transformation. The Gulf states now account for the world’s largest flow of South-South migration, and the growth of the non-national population, as well as rapid urbanization, have also had a profound impact on Gulf society. This volume thus attempts to bridge gaps in understanding the rapid social change in the Gulf, offering practical solutions for policy interventions. It is of interest to scholars and students in Middle Eastern studies, specifically, as well as sociology, media studies, migration studies and educational policy.
    Keywords: Gulf Societies ; Gulf Studies ; Social Change ; Middle East ; Economic Transformation ; Education and Social Change ; Migration and Social Change ; Media and Social Change ; Urbanization ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFN Migration, immigration & emigration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPQ Central government::JPQB Central government policies ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFD Media studies
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  • 12
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    Springer Nature | Springer International Publishing
    Publication Date: 2023-04-18
    Description: This open access IMISCOE Regional Reader explores the issues faced by migrant groups in Southeast Asia and the challenges of getting of their human rights recognized. It analyses the different responses, or lack thereof, of the Association of Southeast Asian Nations (ASEAN) to these highly complex situations which are shaped by contemporary debates around borders and concepts of states, migrants’ rights as well as access to citizenship and how these concepts and paradigms are intertwined with issues such as agency and resilience of migrants. Crucial attention is given to the region’s lesser known populations and issues such as the Vietnamese in Thailand, people of Indonesian descent (PIDs) in Southern Philippines, independent child migrants across the region, and the vulnerabilities of migrant workers facing the COVID-19 pandemic. With its unique regional focus, this book provides a valuable resource to those studying human rights and migration issues, policy makers and researchers and students.
    Keywords: Developments in migration studies in Southeast Asia ; The movement of migrants between vulnerability and victimhood ; The human rights of non-citizens in Southeast Asia ; Challenges of citizenship and borders for migrants ; Forced, irregular and mixed migratory flows in Southeast Asia ; Statelessness, refugees and asylum seekers in Southeast Asia ; Political sensitivities ; The Politics of Migration in Southeast Asia ; Legal identity of migrants and the stateless in Southeast Asia ; Situation of migrants amidst the trans-boundary pandemic Covid19 ; Forced & voluntary migration of Rohingya cross-border movements ; Stateless ethnic Vietnamese in Thailand ; Health systems and healthcare access of migrant populations ; People of Indonesian descent in the Philippines ; Independent Child Migration in Southeast Asia ; Vulnerability, agency and resilience of irregular migrants ; Trafficking and migrant smuggling in Southeast Asia ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFN Migration, immigration & emigration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPV Political control & freedoms::JPVH Human rights ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
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  • 13
    Publication Date: 2024-03-29
    Description: The articles in this collection were first published in the Canberra Times between 14 November 2005 and 22 April 2006 in a slightly different format. In some cases two articles were published on the one secretary. These have been combined into one and minor edits and corrections have been made. The articles have not been updated to take account of events since they were first published.
    Keywords: Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
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  • 14
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    ANU Press
    Publication Date: 2024-03-29
    Description: Fiducial Governance: An Australian republic for the new millennium represents an attempt to grapple with the challenges of designing governance regimes suited to the new millennium. Power's monograph asserts the need for the reform of Australian governance and charts Australia's fitful progress towards a republican future. Along the way he sketches a framework for constitutional reform, mindful of the strengths and weaknesses of the current system of government and the contest of ideas about the role and configuration of Australian Heads of State. Long a frustrated Australian republican, Power contends that the republican log jam is due in significant part to a lack of respect shown by the republican policy community to the contribution long made to good governance by monarchical heads of state. This monograph seeks to draw lessons from this experience, so as to make the republican venture one of substance for the Australian public. In so doing, Power draws on a range of republican, indigenous and feminist writings in order to develop a new framework of 'fiducial governance' aimed at enhancing the trustworthiness and integrity of our institutions of governance, thereby paving the way for the replacement of the monarch by a directly elected head of state. This is an erudite and thoughtful book that will be of interest to those with an interest in systems of governance and to constitutional scholars, whether they be republicans or monarchists.
    Keywords: Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 15
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    ANU Press
    Publication Date: 2024-03-29
    Description: 'Leadership' is routinely admired, vilified, ridiculed, invoked, trivialised, explained and speculated about in the media and in everyday conversation. Despite all this talk, there is surprisingly little consensus about how to answer basic questions about the nature, place, role and impact of leadership in contemporary society. This book brings together academics from a broad array of social science disciplines who are interested in contemporary understandings of leadership in the public domain. Their work on political, administrative and civil society leadership represents a stock-take of what we need to know and offers original examples of what we do know about public leadership. Although this volume connects scholars living in, and mostly working on, public leadership in Australia and New Zealand, their contributions have a much broader scope and relevance.
    Keywords: Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 16
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    ANU Press
    Publication Date: 2024-03-29
    Description: While leadership is an over-used term today, how it is defined for women and the contexts in which it emerges remains elusive. Moreover, women are exhorted to exercise leadership, but occupying leadership positions has its challenges. Issues of access, acceptable behaviour and the development of skills to be successful leaders are just some of them.
    Keywords: Sociology ; Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups::JFSJ1 Gender studies: women ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls
    Language: English
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  • 17
    Publication Date: 2024-03-29
    Description: The main theme of this volume is a discussion of the ways in which legal mechanisms, such as the Land Groups Incorporation Act (1974) in PNG, and the Native Title Act (1993) in Australia, do not, as they purport, serve merely to identify and register already-existing customary indigenous landowning groups in these countries. Because the legislation is an integral part of the way in which indigenous people are defined and managed in relation to the State, it serves to elicit particular responses in landowner organisation and self-identification on the part of indigenous people. These pieces of legislation actively contour the progressive evolution of landowner social, territorial and political organisation at all levels in these nation states. The contributors to this volume provide in-depth anthropological case studies of social structural and cultural transformations engendered by the confrontation between states, developers and indigenous communities over rights to customarily owned land.
    Keywords: Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSL Ethnic studies::JFSL9 Indigenous peoples ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSL Ethnic studies::JBSL1 Ethnic groups and multicultural studies::JBSL11 Indigenous peoples ; thema EDItEUR::5 Interest qualifiers::5P Relating to specific groups and cultures or social and cultural interests::5PB Relating to peoples: ethnic groups, indigenous peoples, cultures and other groupings of people::5PBA Relating to Indigenous peoples
    Language: English
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  • 18
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    Springer Nature | Springer Nature Singapore
    Publication Date: 2024-03-29
    Description: This open access book examines Malaysian politics using a linguistic perspective. It explores how language serves to (de)legitimise governance, and its subsequent policies and activities in Malaysia. Grounded in discourse studies, this edited volume presents research on the discourses produced by and on Barisan Nasional, Pakatan Harapan and Perikatan Nasional from 2008 to 2020, studying how political actors (de)legitimise their governance through discursive means. The thirteen original chapters select spoken, print and digital texts in English, Malay, Mandarin and Tamil, and deploy varied theoretical and methodological approaches. Their linguistic analysis unearths the language features and strategies that facilitate (de)legitimation. It shows how political actors shape the discursive representation and evaluation of multiple concerns in Malaysia. Consequently, Discursive Approaches to Politics in Malaysia: Legitimising Governance improves our understanding of contemporary Malaysian political discourse. It is of interest to graduates and researchers in the field of discourse studies, seeking to understand the discursive contours of politics in this developing Asian country. ; This open access book examines Malaysian politics using a linguistic perspective. It explores how language serves to (de)legitimise governance, and its subsequent policies and activities in Malaysia. Grounded in discourse studies, this edited volume presents research on the discourses produced by and on Barisan Nasional, Pakatan Harapan and Perikatan Nasional from 2008 to 2020, studying how political actors (de)legitimise their governance through discursive means. The thirteen original chapters select spoken, print and digital texts in English, Malay, Mandarin and Tamil, and deploy varied theoretical and methodological approaches. Their linguistic analysis unearths the language features and strategies that facilitate (de)legitimation. It shows how political actors shape the discursive representation and evaluation of multiple concerns in Malaysia. Consequently, Discursive Approaches to Politics in Malaysia: Legitimising Governance improves our understanding of contemporary Malaysian political discourse. It is of interest to graduates and researchers in the field of discourse studies, seeking to understand the discursive contours of politics in this developing Asian country.
    Keywords: Politics in Malaysia ; Media in Malaysia ; Discourse Studies ; Political Discourse ; Language of Politics ; Legitimacy ; Governance ; Barisan Nasional ; Pakatan Harapan ; Perikatan Nasional ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFD Media studies ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCT Media studies ; thema EDItEUR::J Society and Social Sciences ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
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  • 19
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2023-11-17
    Description: The book provides a comprehensive and updated introduction to concept of territory in the study of democratic politics. Territory plays a rather marginal role in the traditional conceptions of democracy that in many ways still prevail today. Democratic politics is often analysed from the point of view of its institutions, citizens and voters, while little is said about the territory through which it is expressed – at most it provides a broader perimeter or context of political and institutional action. The book offers, instead, an introductory theoretically-oriented discussion of crucial issues such as the genesis of state-nation, the transformation of democratic citizenship, the current borders’ policies, the rising of territorial populism and the experience of 19-covid pandemic. This is an open access book.
    Keywords: Democracy ; Territorial Politics ; Populism ; Sociology ; Citizenship ; Covid 19 ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-02
    Description: In this open access book, Mikael Hård tells a story of how people around the world challenged the production techniques and products brought by globalization. Retaining their autonomy and freedom, creative individuals selectively adopted or rejected modern gadgets, tools, and machines. In standard historical narratives, globalization is portrayed as an unstoppable force that flattens all obstacles in its path. Modern technology is also seen as inexorable: in the nineteenth century, steamships, telegraph lines, and Gatling guns are said to have paved the way for colonialism and other forms of dominating people and societies. Later, shipping containers and computer networks purportedly pulled the planet deeper into a maelstrom of capitalism. Hård discusses instances that push back against these narratives. For example, in Soviet times, inhabitants of Samarkand, Uzbekistan, preferred to remain in—and expand—their own mud-brick houses rather than move into prefabricated, concrete residential buildings. Similarly, nineteenth-century Sumatran carpenters ignored the saws brought to them by missionaries—and chose to chop down trees with their arch-bladed adzes. And people in colonial India successfully competed with capitalist-run Caribbean sugar plantations, continuing to produce their own muscovado and sell it to local consumers. This book invites readers to view the history of technology and material culture through the lens of diversity. Based on research funded by the European Research Council and conducted in the Global South, Microhistories of Technology: Making the World shows that the spread of modern technologies did not erase artisanal production methods and traditional tools.
    Keywords: Global South ; History of technology ; Material culture ; Colonialism ; Microhistory ; Global history ; Skill ; thema EDItEUR::N History and Archaeology::NH History::NHB General and world history ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTQ Globalization ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTQ Colonialism and imperialism
    Language: English
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  • 21
    Publication Date: 2023-11-17
    Description: This open access book is a hands-on guide on doing qualitative research in parliaments, exploring achievements and drawbacks for all. From early-career scholars looking for an ‘in’ to start their research to senior academics interested in methodological details, the book offers a novel approach to discussing qualitative methodologies. It presents unique insights based on a large-scale qualitative study in the European Parliament using interview and ethnographic data. Comprehensive yet accessible, the book accounts the step-by-step process of qualitative research in parliaments, offering a reflexive and analytical perspective that moves beyond a textbook or theory-only format.
    Keywords: political science methods ; qualitative methodology ; European Parliament ; political institutions ; research ethics ; research methods ; research limitations ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes::JPHL Political leaders & leadership
    Language: English
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    Springer Nature | Springer International Publishing
    Publication Date: 2024-04-04
    Description: This open access book offers new insights into the Venetian physician Sanctorius Sanctorius (1561–1636) and into the origins of quantification in medicine. At the turn of the seventeenth century, Sanctorius developed instruments to measure and quantify physiological change. As trivial as the quantitative assessment of health issues might seem to us today – in times of fitness trackers and smart watches – it was highly innovative at that time. With his instruments, Sanctorius introduced quantitative research into the field of physiology. Historical accounts of Sanctorius and his work tend to tell the story of a genius who, almost out of the blue, invented a new medical science, based on measurement and quantification, that profoundly influenced modernity. Abandoning the “genius narrative,” this book examines Sanctorius and his work in the broader perspective of processes of knowledge transformation in early modern medicine. It is the first systematic study to include the entire range of the physician’s intellectual and practical activities. Adopting a material culture perspective, the research draws on the contemporary reconstruction of Sanctorius’s most famous instrument: the Sanctorian weighing chair. And here it departs from past studies that focus mainly on Sanctorius’s thinking rather than on his making and doing. The book also re-evaluates Sanctorius’s role in the wider process of the early transformation of medical culture in the early modern period, a process that ultimately led to the abandonment of Galenic medicine and to the introduction of a new medical science, based on the use of quantification and measurement in medical research. The book is therefore an important contribution to the history of medicine and historical epistemology aimed at historians of science and philosophy.
    Keywords: Early Modern History of Medicine ; Early Modern Dietetics ; Early Modern Galenism ; Early Modern Instrumentation ; History of Weighing ; Quantification in Physiology ; Replication Method ; Sanctorius Sanctorius ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDX History of science ; thema EDItEUR::P Mathematics and Science::PD Science: general issues::PDA Philosophy of science ; thema EDItEUR::M Medicine and Nursing::MB Medicine: general issues::MBX History of medicine ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::Q Philosophy and Religion::QD Philosophy::QDT Topics in philosophy::QDTK Philosophy: epistemology and theory of knowledge
    Language: English
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    ANU Press
    Publication Date: 2024-03-29
    Description: 'No nation can escape its geography', warned Percy Spender, Australia's Minister for External Affairs, in 1950. With the immediate turmoil of World War II over, communism and decolonisation had ended any possibility that Asia could continue to be ignored by Australia. In the early 1950s, Australia embarked on its most ambitious attempt to engage with Asia: the Colombo Plan. This book examines the public and private agendas behind Australia's foreign aid diplomacy and reveals the strategic, political and cultural aims that drove the Colombo Plan. It examines the legacy of WWII, how foreign aid was seen as crucial to achieving regional security, how the plan was sold to Australian and Asian audiences, and the changing nature of Australia's relationship with Britain and the United States. Above all this is the question of how Australia sought to project itself into the region, and how Asia was introduced into the Australian consciousness. In answering these questions, this book tells the story of how an insular society, deeply scarred by the turbulence of war, chose to face its regional future.
    Keywords: Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    ANU Press
    Publication Date: 2024-03-29
    Description: Papua New Guinea’s general election in 2007 attracted particular interest for several reasons. Not only did it follow what was widely acknowledged as the country’s worst election ever, in 2002 (in which elections in six of the country’s 109 electorates were declared to be ‘failed elections’), it was the first general election to be held under a new limited preferential voting system. It also followed the first full parliamentary term under the Organic Law on the Integrity of Political Parties and Candidates, which had been introduced in 2001 in an attempt to strengthen political parties and create a greater degree of stability in the national parliament, and was the first to embrace a ‘whole-of-government’ approach to electoral administration, through an Interdepartmental Electoral Committee. This volume provides an analysis of the 2007 election, drawing on the work of a domestic monitoring team organized through the National Research Institute, and several visiting scholars. It addresses key issues such as voter education, electoral administration, election security, the role of political parties, women as candidates and voters, the shift to limited preferential voting, and HIV transmission, and provides detailed accounts of the election in a number of open and provincial electorates. It is generally agreed that the election of 2007 was an improvement on that of 2002. But problems of electoral administration and voting behaviour remain. These are identified in this volume, and recommendations made for electoral reform.
    Keywords: Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This Open Access edited collection calls for a greater understanding of ‘the local’ within the ways the arts, culture and creative practices are governed, promoted, regulated, resourced and valued. Cultural policy studies tends to privilege the national (and international) as the primary site at which cultural policy is enacted, and focuses on the ‘local’ as a case study of practice, rather than a site of policy in its own right. While this may make global policy transfer manageable for national policy agencies, it ignores the contingent relationships, diverse geographies and distinct identities of localities. This volume addresses this gap and is structured around three themes: disciplining the local, which examines key concepts from different academic fields of study; managing the local, which identifies policy approaches that engage with the idea of ‘the local’ in different ways; and practising the local, which offers case studies of how ‘local’ cultural policies are being enacted in places of differing scale and geography.
    Keywords: local cultural policy ; critical cultural policy studies ; localism ; globalization ; cultural planning ; community development ; devolved UK ; arts management ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGC Human geography ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This Open Access textbook is a result of the work of ENTAN – the European Non-Territorial Autonomy Network. It provides students with a comprehensive analysis of the different aspects and issues around the concept of non-territorial autonomy (NTA). The themes of each chapter have been selected to ensure a multi- and interdisciplinary overview of an emerging research field and show both in theory and in practice the possibilities of NTA in addressing cultural, ethnic, religious and language differences in contemporary societies. This is an open access book.
    Keywords: Non-Territorial Autonomy ; Regional Development ; Language Rights ; Minority Rights ; Cultural Rights ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies
    Language: English
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  • 27
    Publication Date: 2024-03-29
    Description: Viet Nam has seen consistent rapid economic growth and impressive declines in poverty since it initiated its Doi Moi economic reforms in the late 1980s. Viet Nam has taken a selective, step-by-step approach to reform—an approach often criticised by proponents of the Washington Consensus. That this approach has been so successful has come as something of a surprise to much of the international community. Analysing closely aspects of Viet Nam's reform process, enterprise development, income growth and poverty alleviation, Viet Nam: a transition tiger? argues that Viet Nam's remarkable development is not readily explained by the more orthodox versions of the Washington Consensus. Successful policy is not built on mechanistic replication of some general reform blueprint, but on responding pragmatically to specific national circumstances. Government policy has had an impact on economic performance but economic experience has also guided the formulation of economic policy. Faced with increasingly complex economic conditions, Vietnamese policymakers will need to rely more than ever on their flexibility and pragmatism if Viet Nam's remarkable economic performance is to be sustained.
    Keywords: Political Science ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 28
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-03-16
    Description: This book discusses and analyses global policies and practices aimed at promoting equity in higher education participation and attainment. Although the massification of higher education systems has facilitated the participation of students from deprived backgrounds, socioeconomic inequalities persist in access to the most prestigious institutions and programmes. Privileged students benefit from a number of advantages in the competition for selective and scarce places: access to information, lower aversion to debt, higher expectations, better previous schooling and higher academic achievement. The chapters present a critical analysis of equity policies in different countries – with or without affirmative action policies, within a context of neoliberal policies or within a social democratic model – and the reasons why they have failed to promote equity and fairness, preventing students from achieving their full educational potential. This is an open access book.
    Keywords: equity in higher education ; access to higher education ; participation in higher education ; attainment and retention ; higher education policy ; Open Access ; bic Book Industry Communication::J Society & social sciences::JN Education::JNM Higher & further education, tertiary education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 29
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    Springer Nature | Springer
    Publication Date: 2022-03-16
    Description: This open access book focuses on Albanian internal and international female migration and places gender at the heart of postsocialist transformation. It explores the vulnerabilities that arise for female citizens from the contradictory policies produced by the Albanian state. By illuminating the intersection of gender and migration, it shows how Albanian women are likely to embed themselves in complex social relations and migration trajectories. By focusing on various cases – internal, international, return, economic and student female migrants – the book underlines that migration does not follow any kind of evolutionary development, according to which women go from 'traditional’ to ‘modern' gender relations. By providing a compelling account on the complex negotiations and tactics women employ to deal with gender inequalities, this book leads to a better understanding of gender and migration entanglements. It is a useful read to students, academics in migration and gender studies as well as social scientists and policy-makers in European countries.
    Keywords: Albanian female migration ; Gender relations and post-socialist transformations ; Internal and international female student migration ; Internal and international care chains ; Post-socialist migratory processes ; Tactics and strategies mobilised by women ; Informality and rudimentary welfare state ; Education as a platform for migration in Albania ; Invisibility of domestic care work sector in Albania ; Intersections of care, gender and migration regimes ; Gendered imaginaries of Albanian female migrants ; Albanian migrants filling the care gap in Italy and Greece ; Commercialization of care ; Social networks in post-socialist Albanian migration ; Open access ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFN Migration, immigration & emigration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-04-02
    Description: This open access book draws on conceptual resources ranging from medieval scholasticism to postmodern theory to propose a new understanding of secular time and its mediation in nineteenth-century technological networks. Untethering the concept of secularity from questions of ‘religion’ and ‘belief’, it offers an innovative rethinking of the history of secularisation that will appeal to students, scholars, and everyone interested in secularity, Victorian culture, the history of technology, and the temporalities of modernity.
    Keywords: Victorian secularisation ; modernity ; non-religion ; nineteenth-century history ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::Q Philosophy and Religion::QR Religion and beliefs::QRA Religion: general::QRAX History of religion ; thema EDItEUR::N History and Archaeology::NH History::NHT History: specific events and topics::NHTB Social and cultural history ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-02-15
    Description: This open access book examines why Japan discontinued its quarter-century history of troop contribution to UN Peacekeeping Operations (1992–2017). Japan had deployed its troops as UN peacekeepers since 1992, albeit under a constitutional limit on weapons use. Japan’s peacekeepers began to focus on engineering work as its strength, while also trying to relax the constraints on weapons use, although to a minimal extent. In 2017, however, Japan suddenly withdrew its engineering corps from South Sudan, and has contributed no troops since then. Why? The book argues that Japan could not match the increasing “robustness” of recent peacekeeping operations and has begun to seek a new direction, such as capacity-building support.
    Keywords: Open Access ; Japanese studies ; peacekeeping ; peacebuilding ; security policy ; United Nations ; Japanese foreign policy ; SDG 16 ; sustainable development goals ; peace operations ; Japan’s contribution to global peace ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::H Humanities::HB History::HBJ Regional & national history::HBJF Asian history
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-09-22
    Description: Europe’s future is contested between those who want to integrate further, those who prefer things to stay as they are, and those who would retreat into nationalism. These divisions impair the government of the European Union and weaken its ability to shoulder more responsibility for its unstable neighbourhood. This open access book analyses the EU’s evolving constitution, arguing that the lack of effective federal government lies at the heart of its problems. It recommends reforms for each EU institution, including those involving treaty change. It makes the case for a unified executive, a more legitimate legislature, and the introduction of a federal treasury and supreme court. It proposes a fresh category of affiliate membership underpinned by a new European security council that would overcome the historic division between the EU and NATO. The book is essential reading for practitioners and students of European integration.
    Keywords: EU ; Federal union ; EU treaty reform ; Security and defence ; European constitution ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-11-19
    Description: This open access book is the product of three years of academic research that has been carried out in the EU-funded Jean Monnet Network on “Post-Truth Politics, Nationalism and the Delegitimation of European Integration” since 2019. Drawing on the multidisciplinary expertise of the network’s members, the book explores the impact of the phenomenon of post-truth politics on European integration and the European Union. It places particular emphasis on how post-truth politics has played out in the public sphere and asks what impact the phenomenon has had on public deliberation, but reflects also on its implications for democracy in a wider sense. This book is primarily written for audiences with an interest in politics and policy making, including academics, policy makers and civil-society actors. Thanks to its accessible style, the book should however also be an asset to wider audiences.
    Keywords: Post-Truth Politics ; Public Sphere ; Deliberation ; European Integration ; Migration ; Media ; Populism ; Fake News ; Democracy ; Postmodernism ; Journalism ; Brexit ; Immigration ; Social Media ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory
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    Springer Nature | Springer Singapore
    Publication Date: 2022-03-16
    Description: This is an Open Access book. The primary objective of this book is to seek out insights into the concept of high-quality growth (HQG). It explores the essential attributes of HQG, such as inclusiveness, sustainability, and resilience, as well as its relationship with transformation, by drawing principally on illustrative cases and instances of international cooperation. The United Nations document on Sustainable Development Goals (SDGs) states that “We resolve to create conditions for sustainable, inclusive and sustained economic growth, shared prosperity and decent work for all.” As such, the concept of quality growth is inherent in many aspects of the SDGs. A similar approach can be seen in the Development Cooperation Charter announced by the Japanese government in 2015. According to the Charter, one of the most important challenges of development is quality growth and the reduction of poverty achieved through such growth. The approach in the Charter emphasizes inclusiveness, sustainability, and resilience. This volume is a pioneering study on quality growth as well as its relationship with SDGs and transformation. Comprehensive studies on quality growth are very few. The case study approach distinguishes the present volume from some previous literature that discussed quality growth within the framework of general policy. Instead, in this book, concrete cases and experiences provide insights into hands-on “ingredients”. Through the case studies, it can be seen more clearly that transformation and quality growth are phenomena that do not occur automatically but, rather, ones that require specific, properly designed strategies and approaches. Another unique feature of this book is that it aims to make explicit some of the consistent, but implicit, principles of Japan’s international cooperation.
    Keywords: Sustainable Development Goals (SDGs) ; quality growth ; inclusive growth ; industrial strategy ; environmental sustaimability ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCM Development economics & emerging economies ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCG Economic growth ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCL International economics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
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  • 35
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    Springer Nature | Springer
    Publication Date: 2024-03-29
    Description: This open access volume analyses the development of democracy at different levels of governance (from local to global). The Basque search for an institutional and democratic model that adapts to its social needs and solves its problems offers an interesting perspective for analyzing the way in which democracy is seeking new forms of materialization from the local to the global. The volume is divided into four parts. The chapters in Part I analyze the tensions between the neoliberal vision of democracy and the voices contesting it, with projections at different levels of government. The chapters in Part II focus on the emerging framework and scales of Western democracy. The chapters in Part III present new forms of citizen participation, paying special - though not exclusive - attention to new practical strategies for Basque society. The volume concludes with a block of chapters on the relevance of reviewing the methodological and epistemological frameworks from which knowledge about democracy and mechanisms of citizen participation is generated (Part IV). By delving deeper into the idea and practice of democratic governance, this volume will be of interest to researchers and students from all disciplines of politics, international relations, sociology and law.
    Keywords: Basque Country ; Basque society ; Western democracy ; neolibralism ; inequality ; citizen participation ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPH Political structure and processes ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPP Public administration
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This open access book gives insights into feminist methodologies in theory and practice. By foregrounding the experiential and embodied nature of doing feminist research, this book offers valuable tools for feminist research as a continuous praxis. Emerging from a rich collective learning process, the collection offers in-depth reflections on how feminists shape research questions, understand positionality, share research results beyond academe and produce feminist intersectional knowledges. This book reveals how the authors navigate theory and practice, candidly exploring the difficulty of producing knowledge on the edge of academia and activism. From different points of view, places and disciplinary positions, artistic and creative experiments and collaborations, the book provides a multi-layered analysis. This book will be a valuable resource and asset to early career researchers and interdisciplinary feminist students who can learn more about the doing of feminist research from realistic, accessible, and practical methodological tools and knowledge.
    Keywords: feminist ; development studies ; methodology ; feminist methodologies ; Gender studies ; social movements ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPA Political science & theory ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPA Political science and theory
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-11-19
    Description: This open access book responds to the need for a specifically African focus on public policy. It outlines the fundamental principles of public policy research, and engages with major issues in the study of public policy from an African perspective, covering essential topics such as the location and centrality of social sciences in relation to public policy, leadership, methodology, institutions, governance, and gender. This book is essential for understanding the various aspects and dimensions of policy making in Africa that underscore quality research and are at the core of excellence in teaching and learning.
    Keywords: public policy ; governance in Africa ; African politics ; policy research ; gender and diversity ; global policy ; public sector innovation ; political economy of public policy ; political leadership ; research communication ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes
    Language: English
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    Springer Nature | Springer
    Publication Date: 2024-03-29
    Description: This open access book presents an actor-centered study on Europeanization, based on the assumption that EU-driven reforms are highly dependent on the behavior and interests of the key domestic actors. Whether or not a state pursues a European and democratic agenda depends on domestic lawmakers. Further, political elites are pre-eminent in deciding on the nature, form and content of any law, and on the extent to which the rule of law is actually enforced. Elites can overcome structural or institutional barriers that stand in the way of achieving their goals. The empirical study on Romania presented here lends this observation a more profound meaning: it shows how, in contexts where high level corruption is the norm rather than the exception, self-serving political elites cannot be expected to genuinely commit to adopting sound anti-corruption reform. The book is an inquiry into the motivations that drive legislators to make particular decisions, but also into the structural characteristics and dynamics of the elite that invite a selfish rather than responsible and responsive behaviour. This publication was supported by funds from the Publication Fund for Open Access Monographs of the Federal State of Brandenburg, Germany.
    Keywords: Europeanization ; Romania ; European Union ; EU ; post-accession conditionality ; Central and Eastern Europe ; political elite ; corruption ; justice reform ; civil society empowerment ; European Union Politics ; Russian and Post-Soviet Politics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPB Comparative politics ; thema EDItEUR::J Society and Social Sciences::JH Sociology and anthropology::JHB Sociology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPP Public administration ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics
    Language: English
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2024-03-29
    Description: This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com. Barbara Wootton was one of the extraordinary public figures of the twentieth century. She was an outstanding social scientist, an architect of the welfare state, an iconoclast who challenged conventional wisdoms and the first woman to sit on the Woolsack in the House of Lords. Ann Oakley has written a fascinating and highly readable account of the life and work of this singular woman, but the book goes much further. It is an engaged account of the making of British social policy at a critical period seen through the lens of the life and work of a pivotal figure. Oakley tells a story about the intersections of the public and the private and about the way her subject's life unfolded within, was shaped by, and helped to shape a particular social and intellectual context.
    Keywords: Biography: historical, political and military ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology ; bic Book Industry Communication::H Humanities::HB History::HBL History: earliest times to present day::HBLW 20th century history: c 1900 to c 2000 ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups::JFSJ1 Gender studies: women ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology ; thema EDItEUR::N History and Archaeology ; thema EDItEUR::3 Time period qualifiers::3M c 1500 onwards to present day::3MP 20th century, c 1900 to c 1999 ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBS Social groups, communities and identities::JBSF Gender studies, gender groups::JBSF1 Gender studies: women and girls ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    Springer Nature | Springer Fachmedien Wiesbaden
    Publication Date: 2022-11-19
    Description: This Open-Access-Book covers different aspects of the low-carbon energy transformation in a unique manner, with a particular focus on two regions, South Asia and Sub-Saharan Africa. The first part of the book provides useful insights on changes and reforms in the energy sector of Bangladesh, while the second part illustrates the low-carbon energy transformation in South Asia and the third part covers lessons from Sub-Saharan Africa. In all of these regions, the energy sector is undergoing major changes, driven by the four D’s: Decarbonization, decentralization, digitization, and democratization. Major overhauls are taking place at all levels: The country level, where energy mixes are rapidly changing, the corporate level, where large state-owned and private companies are challenged and new actors are emerging, and the local level, where technical and regulatory change has made citizen engagement and community power an option to replace or at least complement centralized supply structures.
    Keywords: Energy Access ; Decarbonization ; Integration of Renewables ; Sub-Sahara Africa ; Bangladesh ; Decentralization ; Electricity Access ; Energy Transformation ; South Asia ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCN Environmental economics ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::T Technology, engineering, agriculture::TH Energy technology & engineering::THX Alternative & renewable energy sources & technology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: The book addresses the compelling questions concerning the ideals of African citizenship, the processes of learning to fulfill these ideals, and possibilities of education in fostering citizenship. Rather than advocating for one particular framework, the authors demonstrate the continuously contested nature of the concept of citizenship as both theoretically discussed by philosophers and practically experienced in daily lives. The monograph combines, in an unconventional way, selected philosophical accounts and everyday experiences from certain locations in Tanzania and Uganda. It provides contributions from philosophical ideas drawing on scholars such as Chantal Mouffe, Rosi Braidotti, Theodor Adorno and Étienne Balibar on one hand, and the conceptions articulated by groups of inhabitants of rural and urban settings in Africa, on the other hand. Therefore, the book offers fresh readings under the lenses of citizenship and learning. This is an open access book.
    Keywords: Citizenship ; Africa ; African Studies ; Development ; International development ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2022-10-15
    Description: This book is available as open access through the Bloomsbury Open Access programme and is available on bloomsburycollections.com. While good governance is a worthy goal, this book argues that it is not a prerequisite for economic growth or development. The book exposes the methodological shortcomings of the commonly-used governance indicators developed within the World Bank. The authors argue that donors should not impose onerous good governance conditions, expecting the developing world to simulate now-developed countries. They contend that most poor countries lack the administrative and financial capacity to achieve these reforms or institutions - so donor conditionality often becomes a recipe for failure. In place of grand government reforms aimed at enhancing market efficiency, the book's position is that the reform agenda should target strategic bottlenecks for development and enhance the state's capacity to deal with these disruptions. Bringing together contributions from leading political scientists, political economists and development practitioners, this is the first book to provide a systematic critical perspective on received notions of good governance.
    Keywords: Development economics and emerging economies ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCM Development economics & emerging economies ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCS Economic systems & structures ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2024-03-29
    Description: This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com. Having emerged from the end of the Cold War as a unified country, Germany has quickly become the second largest exporter in the world. Its economic might has made it the center of the Eurozone and the pivotal power of Europe. Like other geo-economic powers, Germany's foreign policy is characterized by a definition of the national interest in economic terms and the elevation of economic interests over non-economic values such as human rights or democracy promotion. This strategic paradigm is evident in German's relationship with China, the Gulf States and Europe, but it is most important in regard to its evolving policies towards Russia. In this book, Stephen F. Szabo provides a description and analysis of German policy towards Russia, revealing how unified Germany is finding its global role in which its interests do not always coincide with the United States or its European partners. He explores the role of German business and finance in the shaping of foreign policy and investigates how Germany's Russia policy effects its broader foreign policy in the region and at how it is perceived by key outside players such as the United States, Poland and the EU. With reference to public, opinion, the media and think tanks Szabo reveals how Germans perceive Russians, and he uncovers the ways in which its dealings with Russia affect Germany in terms of the importing of corruption and crime. Drawing on interviews with key opinion-shapers, business and financial players and policy makers and on a wide variety of public opinion surveys, media reports and archival sources, his will be a key resource for all those wishing to understand the new geo-economic balance of Europe.
    Keywords: Political economy ; International relations ; Central / national / federal government policies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations::JPSL Geopolitics ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations::JPSL Geopolitics ; thema EDItEUR::K Economics, Finance, Business and Management::KC Economics::KCP Political economy
    Language: English
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    Springer Nature | Springer Singapore
    Publication Date: 2024-03-29
    Description: This open access book consists of essays written by Kishore Mahbubani to explore the challenges and dilemmas faced by the West and Asia in an increasingly interdependent world village and intensifying geopolitical competition. The contents cover four parts: Part One The End of the Era of Western Domination. The major strategic error that the West is now making is to refuse to accept this reality. The West needs to learn how to act strategically in a world where they are no longer the number 1. Part Two The Return of Asia. From the years 1 to 1820, the largest economies in the world were Asian. After 1820 and the rise of the West, however, great Asian civilizations like China and India were dominated and humiliated. The twenty-first century will see the return of Asia to the center of the world stage. Part Three The Peaceful Rise of China. The shift in the balance of power to the East has been most pronounced in the rise of China. While this rise has been peaceful, many in the West have responded with considerable concern over the influence China will have on the world order. Part Four Globalization, Multilateralism and Cooperation. Many of the world’s pressing issues, such as COVID-19 and climate change, are global issues and will require global cooperation to deal with. In short, human beings now live in a global village. States must work with each other, and we need a world order that enables and facilitates cooperation in our global village.
    Keywords: US-China Relations ; Western Decline ; Asia Rising ; China in the 21st Century ; Plutocracy and Meritocracy ; International Institutions ; COVID-19 Pandemic ; Geopolitical Contest ; Globalization and Governance ; Competition or Coexistence ; Open Access ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-07-14
    Description: This open access book provides the first ever authoritative collection of scholarly insights, based upon original research, into the political groups of the EP tackling the fundamental changes since the Lisbon Treaty and the upsurge of radical right parties. It analyses political groups and their importance from multiple perspectives critically assessing their role and significance in EU politics. Each chapter is authored by leading scholars in the field, working on key topics in relation to political groups: political group formation and function, their role in parliamentary and EU policy-making, the way that Eurosceptic MEPs influence (or not) the Parliament, and the nature and form of interactions with external actors. In doing so, each chapter opens hitherto unexplored ‘black boxes’ in the political work of the EP, such as the internal practices of, and power relations within the political groups, and informal arenas of intra-group decision-making.
    Keywords: European Union Politics ; European Parliament ; Homogenous ; Policy-Making ; Democracy ; Organization ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes
    Language: English
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2022-10-15
    Description: This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com. Government communication is a curiously neglected area of discursive analysis. No considered examination of the subject exists which provides either an account of the contemporary governmental landscape or an explanation of the common and divergent themes on both a domestic and international basis. This volume aims to fill that gap, providing a concise and illuminating case-study based review of government communication. It will be divided into three sections to reflect differences in both geography and political allegiances, scrutinizing continental Europe, Anglo-American traditions and newly emerging democracies. Offering a global and thematic account, it is an indispensable resource for all students of political communication.
    Keywords: News media and journalism ; Politics and government ; Media studies ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTC Communication studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFD Media studies ; bic Book Industry Communication::K Economics, finance, business & management::KN Industry & industrial studies::KNT Media, information & communication industries::KNTJ Press & journalism ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
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    ANU Press | ANU Press
    Publication Date: 2022-10-26
    Description: In a previous volume, State and Society in Papua New Guinea: The First Twenty-Five Years (2001, reprinted by ANU E Press in 2004), a collection of papers by the author published between 1971 and 2001 was put together to mark Papua New Guinea's first 25 years as an independent state. This volume presents a collection of papers written between 2001 and 2021, which update the story of political and social development in Papua New Guinea in the first two decades of the twenty-first century. The chapters cover a range of topics, from an evaluation of proposals for political reform in the early 2000s, a review of the discussion of 'failing states’ in the island Pacific and the shift to limited preferential voting in 2007, to a detailed account of political developments from the move against Sir Michael Somare in 2011 to the election of Prime Minister Marape and his performance to 2022. There are also chapters on language policy, external and internal security, religious fundamentalism and national identity, and the sustainability of economic growth.
    Keywords: Papua New Guinea ; Melanesia ; development ; Political reform ; elections ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-11-19
    Description: This open access book provides the theoretical and pedagogical foundations for a promising new approach to civic education: using social media to teach civics. While many measures indicate that youth civic engagement has long been in decline, many of these measures fail to take into account all of the ways that youth can interact with civic life. One of these understudied ways is through social media, including platforms like Twitter, where young people have the opportunity to encounter the news, engage with people in power, and bring attention to the needs in their community. Throughout this volume, Chapman explores how and why teachers can use social media to teach civics, as well as how it might meet the needs of students in ways other approaches do not.
    Keywords: civic education ; civic engagement ; social media ; civic participation ; social justice ; social media education ; youth democracy ; youth citizenship ; bic Book Industry Communication::J Society & social sciences::JN Education::JNF Educational strategies & policy ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies ; bic Book Industry Communication::J Society & social sciences::JN Education ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFD Media studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
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    Bloomsbury Academic | Bloomsbury Academic
    Publication Date: 2024-03-29
    Description: This book is available as open access through the Bloomsbury Open Access programme and is available on www.bloomsburycollections.com. Griffiths, Kippin and Stoker bring together many of the country’s leading academic and policy experts to explore the long-term challenges facing public services, and ask what the role of government, citizens and society should be in addressing them. The book sets out a new reform agenda, exploring possibilities for the future design and delivery of public services in the UK and beyond. Public Services: A New Reform Agenda is an important new contribution to the debate that will be invaluable for policymakers, practitioners and academics.
    Keywords: Social welfare and social services ; Central / national / federal government ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-11-19
    Description: This open access book offers a compelling account of everyday life, livelihoods, and governance in post-apartheid South Africa among the urban poor and marginalized, anchored in and through a critique of the concept of informality, or living outside of the state, its laws, services, and protection. Using a case study of the Zama Zama, loosely translated from the isiZulu as ‘to hustle, or to strive’ and colloquially used to refer to those working as informal artisanal miners on Johannesburg’s numerous disused and abandoned gold mines, the book documents an ethnography of this community’s everyday lives, struggles, and hopes. It provides an intimate account of a community, its social relations, and its political relationship to the state. The narratives of the Zama Zama are used to raise broader questions about precarity, belonging, and governance in post-apartheid South Africa, and suggest that pervasive informality could risk the country's democratic order.
    Keywords: Global South politics ; informal economies ; artisanal mining ; South Africa ; urban governance ; South African politics and governance ; migration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2022-09-22
    Description: This Open Access book explains ASEAN’s strategic role in managing great power politics in East Asia. Constructing a theory of institutional strategy, this book argues that the regional security institutions in Southeast Asia, ASEAN and ASEAN-led institutions have devised their own institutional strategies vis-à-vis the South China Sea and navigated the great-power politics since the 1990s. ASEAN proliferated new security institutions in the 1990s and 2000s that assumed a different functionality, a different geopolitical scope, and thus a different institutional strategy. In so doing, ASEAN formed a “strategic institutional web” that nurtured a quasi-division of labor among the institutions to maintain relative stability in the South China Sea. Unlike the conventional analysis on ASEAN, this study disaggregates “ASEAN” as a collective regional actor into specific individual institutions—ASEAN Foreign Ministers’ Meeting, ASEAN Summit, ASEAN-China dialogues, ASEAN Regional Forum, East Asia Summit, and ASEAN Defense Ministers Meeting and ASEAN Defense Ministers Meeting-Plus—and explains how each of these institutions has devised and/or shifted its institutional strategy to curb great powers’ ambition in dominating the South China Sea while navigating great power competition. The book sheds light on the strategic potential and limitations of ASEAN and ASEAN-led security institutions, offers implications for the future role of ASEAN in the Indo-Pacific region, and provides an alternative understanding of the strategic utilities of regional security institutions.
    Keywords: ASEAN ; Institutional Strategy in Southeast Asia ; Rise of China ; Balance of Power in Southeast Asia ; Secondary Power in Southeast Asia ; Great Power Politics in Southeast Asia ; East Asia ; Power Shift in Asia ; Regional Security Institution ; South China Sea ; ASEAN Regional Forum ; ASEAN Defense Ministers Meeting ; ADMM-Plus ; ASEAN+3 ; East Asia Summit ; ASEAN Ministerial Meeting ; ASEAN Summit ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations::JPSN International institutions ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations::JPSD Diplomacy
    Language: English
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This open access book provides insights into the everyday lives of long-term prisoners in Switzerland who are labelled as ‘dangerous’ and are preventatively held in indefinite, probably lifelong, incarceration. It explores prisoners’ manifold ways of inhabiting the prison which can be used to challenge well established notions about the experience of imprisonment, such as ‘adaptation’, ‘coping’, and ‘resistance’. Drawing on ethnographic data generated in two high-security prisons housing male offenders, this book explores how the various spaces of the prison affect prisoners’ sense of self and experience of time, and how, in particular, the indeterminate nature of their imprisonment affects their perceptions of place and space. It sheds light on prisoners’ subjective, emplaced and embodied perceptions of the prisons' various everyday time-spaces in the cell, at work, and during leisure time, and the forms of agency they express. It provides insight into prisoners’ everyday habits, practices, routines, and rhythms as well as the profoundly existential issues that are engendered, (re)arranged, and anchored in these everyday contexts. It also offers insights into the penal policies, norms, and practices developed and followed by prison authorities and staff.
    Keywords: Carceral Geography ; prison ; incarceration ; life sentence ; imprisonment ; rehabilitation ; ethnography ; forensic psychology ; prison cell ; prison sociology ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKV Crime & criminology::JKVP Penology & punishment ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPV Political control & freedoms::JPVH Human rights ; bic Book Industry Communication::J Society & social sciences::JK Social services & welfare, criminology::JKV Crime & criminology ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RG Geography::RGC Human geography ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JM Psychology::JMK Criminal or forensic psychology ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology::JKVP Penology and punishment ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPV Political control and freedoms::JPVH Human rights, civil rights ; thema EDItEUR::J Society and Social Sciences::JK Social services and welfare, criminology::JKV Crime and criminology ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RG Geography::RGC Human geography ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JM Psychology::JMK Criminal or forensic psychology
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    Publication Date: 2024-04-11
    Description: It has become more evident that many microalgae respond very differently than land plants to diverse stimuli. Therefore, we cannot reduce microalgae biology to what we have learned from land plants biology. However, we are still at the beginning of a comprehensive understanding of microalgae biology. Microalgae have been posited several times as prime candidates for the development of sustainable energy platforms, making thus the in-depth understanding of their biological features an important objective. Thus, the knowledge related to the basics of microalgae biology must be acquired and shared rapidly, fostering the development of potential applications. Microalgae biology has been studied for more than forty years now and more intensely since the 1970’s, when genetics and molecular biology approaches were integrated into the research programs. Recently, studies on the molecular physiology of microalgae have provided evidences on the particularities of these organisms, mainly in model species, such as Chlamydomonas reinhardtii. Of note, cellular responses in microalgae produce very interesting phenotypes, such as high lipid content in nitrogen deprived cells, increased protein content in cells under high CO2 concentrations, the modification of flagella structure and motility in basal body mutant strains, the different ancient proteins that microalgae uses to dissipate the harmful excess of light energy, the hydrogen production in cells under sulfur deprivation, to mention just a few. Moreover, several research groups are using high-throughput and data-driven technologies, including “omics” approaches to investigate microalgae cellular responses at a system-wide level, revealing new features of microalgae biology, highlighting differences between microalgae and land plants. It has been amazing to observe the efforts towards the development and optimization of new technologies required for the proper study of microalgae, including methods that opened new paths to the investigation of important processes such as regulatory mechanisms, signaling crosstalk, chemotactic mechanisms, light responses, chloroplast controlled mechanisms, among others. This is an exciting moment in microalgae research when novel data are been produced and applied by research groups from different areas, such as bioprocesses and biotechnology. Moreover, there has been an increased amount of research groups focused in the study of microalgae as a sustainable source for bioremediation, synthesis of bioproducts and development of bioenergy. Innovative strategies are combining the knowledge of basic sciences on microalgae into their applied processes, resulting in the progression of many applications that hopefully, will achieve the necessary degree of optimization for economically feasible large-scale applications. Advances on the areas of basic microalgae biology and novelties on the essential cellular processes were revealed. Progress in the applied science showed the use of the basic science knowledge into fostering translational research, proposing novel strategies for a sustainable world scenario. In this present e-book, articles presented by research groups from different scientific areas showed, successfully, the increased development of the microalgae research. Herewith, you will find articles ranging from bioprospecting regional microalgae species, through advances in microalgae molecular physiology to the development of techniques for characterization of biomass and the use of biomass into agriculture and bioenergy production. This e-book is an excellent source of knowledge for those working with microalgae basic and applied sciences, and a great opportunity for researchers from both areas to have an overview of the amazing possibilities we have for building an environmentally sustainable future once the knowledge is translated into novel applications.
    Keywords: TA1-2040 ; TP248.13-248.65 ; QK1-989 ; Q1-390 ; Biotechnology ; biomass ; Hydrogen ; bioenergy ; Nutrients ; Lipids ; Microalgae ; Biofuels ; sustainability ; Carbon Dioxide ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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    ANU Press
    Publication Date: 2022-04-28
    Description: Government policy; Social conditions; Aboriginal australians
    Keywords: government policy ; social conditions ; aboriginal australians ; Census ; Community Development Employment Projects ; Darwin ; Northern Territory ; Indigenous Australians ; Northern Territory ; Wadeye ; Northern Territory ; Workforce ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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    Publication Date: 2023-12-21
    Description: It is now well appreciated that the immune system, in addition to its traditional role in defending the organism against pathogens, communicate in a well-organized fashion with the brain to maintain homeostasis and regulate a set of neural functions. Perturbation in this brain-immune interactions due to inflammatory responses may lead to psychiatric and neurological disorders. Microglia are one of the essential cells involved in the brain-immune interactions. Microglial cells are now not simply regarded as resident tissue macrophages in the brain. These cells are derived from myeloid progenitor cells in the yolk sac in early gestation, travel to the brain parenchyma and interact actively with neurons during the critical period of neurogenesis. Microglia provide a trophic support to developing neurons and take part in the neural wiring through the activity-dependent synapse elimination via direct neuron-microglia interactions. Altered microglial functions including changes in the gene expression due to early life inflammatory events or psychological and environmental stressors can be causally related to neurodevelopmental diseases and mental health disorders. This type of alterations in the neural functions can occur in the absence of infiltration of inflammatory cells in the brain parenchyma or leptomeninges. In this sense, the pathogenetic state underlying a significant part of psychiatric and neurological diseases may be similar to “para-inflammation”, an intermediate state between homeostatic and classical inflammatory states as defined by Ruslan Medzhitov (Nature 454:428-35, 2008). Therefore, it is important to study how systemic inflammation affects brain health and how local peripheral inflammation induces changes in the brain microenvironment. Chronic pain is also induced by disturbance in otherwise well-organized multisystem interplay comprising of reciprocal neural, endocrine and immune interactions. Especially, early-life insults including exposure to immune challenges can alter the neuroanatomical components of nociception, which induces altered pain response later in life. Recently the discrete roles of microglia and blood monocyte-derived macrophages are being defined. The distinction may be further highlighted by disorders in which the brain parenchymal tissue is damaged. Therefore, studies investigating the dynamics of immune cells in traumatic brain injury and neurotropic viral infections including human immunodeficiency virus, etc. as well as neurodegenerative diseases such as amyotrophic lateral sclerosis are promising to clarify the interplay between the central nervous and immune systems. The understanding of the histological architecture providing the infrastructure of such neuro-immune interplay is also essential. This Frontiers research topic brings together fourteen articles and aims to create a platform for researchers in the field of psychoneuroimmunology to share the recent theories, hypotheses and future perspectives regarding open questions on the mechanisms of cell-cell interactions with chemical mediators among the nervous, immune and endocrine systems. We hope that this platform would reveal the relevance of the studies on multisystem interactions to enhance the understanding of the mechanisms underlying a wide variety of neurological and psychiatric disorders.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; brain-immune interaction ; fatigue ; pain ; HIV ; neuroinflammation ; traumatic brain injury ; depression ; microglia ; amyotrophic lateral sclerosis ; autism ; bic Book Industry Communication::M Medicine
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    Publication Date: 2023-12-21
    Description: Microglia are essential for the development and function of the adult brain. Their ontogeny, together with the absence of turnover from the periphery and the singular environment of the central nervous system (CNS), make microglia a unique cell population compared to other tissue-macrophages. The unique properties and functions of microglial cells, such as their role in synaptic pruning or the exceptional capacity to scan the brain parenchyma and rapidly react to its perturbations, have emerged in recent years. In the coming years, understanding how microglia acquire and maintain their unique profiles in order to fulfil distinct tasks in the healthy CNS and how these are altered in disease, will be essential to develop strategies to diagnose or treat CNS disorders with an immunological component. This Research Topic covers several aspects of microglial biology, ranging from their origin and the functional role of microglia during development and lifespan, their molecular properties compared with other brain and peripheral immune cells to microglial phenotypes and functional states in neurodegenerative diseases and brain tumours. In conclusion, the present Research Topic provides a comprehensive overview of our current understanding of several cellular and molecular mechanisms that make microglia a unique immune cell population within the healthy CNS as well as under inflammatory, neurodegenerative and tumorigenic processes.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; inflammation ; brain tumour ; neurodegeneration ; microglia ; ontogeny ; bic Book Industry Communication::M Medicine
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  • 57
    Publication Date: 2023-12-21
    Description: The non-classical HLA class I molecule HLA-G is different from classical HLA class I molecules because of the low polymorphism in the coding region, the fact that HLA-G primary transcript is alternatively spliced in seven isoforms, and the inhibitory action on immune cells. Although HLA-G is low polymorphic, variants in both promoter and 3’ un-translated region (UTR) of HLA-G locus regulate its expression. In healthy conditions, a basal level of HLA-G gene transcription is observed in most cells and tissues; however, translation into HLA-G protein is restricted to trophoblasts in the placenta, where it participates in promoting tolerance at the fetal-maternal interface. HLA-G is also expressed by thymic epitelial, cornea, mesenchymal stem cells, nail matrix, pancreatic beta cells, erythroid, and endothelial precursors. HLA-G can be neo-expressed in adult tissues in pathological conditions, and its expression has been documented autoimmune disorders, viral infections, and cancer. In the latter setting de novo HLA-G expression is associated with the capability of tumor cells to evade the immune control. In the last decade it has become evident that HLA-G expression on T cells and antigenpresenting cells confers to these cells tolerogenic properties. This Research Topic focused on i) summarizing updated clinical and immunological evidences that HLA-G expression is associate with beneficial or detrimental tolerance, ii) gathering new insights into the mechanisms governing the expression of HLA-G in healthy and pathological conditions, such as pre-eclampsia, and iii) examining the mechanisms underlying HLA-G mediated tolerance.
    Keywords: R5-920 ; RC581-607 ; Pregnancy ; Autoimmunity ; Immuno-modulation ; Pre-Eclampsia ; Infections ; Exosomes ; HLA-G ; polymorphisms ; tolerance ; Cancer ; bic Book Industry Communication::M Medicine
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  • 58
    Publication Date: 2023-12-21
    Description: Lymphocytes constantly survey the lymph nodes in search for potential infection by a pathogen. They enter the afferent lymphatic vessel that serves as a conduit to transport the motile lymphocytes to the draining lymph node. Lymphatic vessels (LVs) are present in most vascularized tissues. They are traditionally regarded as passive conduits for soluble antigens and leukocytes. Afferent LVs begin as blind ended capillaries, which give rise to collecting vessels that merge and connect with draining lymph nodes (dLNs). Initial lymphatic capillaries are composed of Lymphatic Endothelial Cells (LECs) connected by discontinuous cell junctions, which join to form larger collecting lymphatic vessels, and ultimately feed into the LN subcapsular sinus. Within the LN, LECs are localized to the subcapsular, cortical, and medullary sinuses, where they interact with incoming and exiting leukocytes. LECs, and in general LN stromal cells, have emerged in the recent years as active players in the immune response. In support to this,studies have shown that the immune response generated during inflammation and under pathologic conditions is accompanied by modeling of the LVs and generation of new lymphatics, a process known as lymphangiogenesis. These facts strongly suggest that LECs and stromal LN cells in general, are not inert players but rather are part of the immune response by organizing immune cells movement, exchanging information and supplying survival factors. The purpose of this research topic is to review the role of the LECs during immune homeostasis and cancer. Considering the critical role of lymphangiogenesis in many pathologies like chronic and acute inflammation, autoimmunity, wound healing, graft rejection, and tumor metastasis, it is important to understand the molecular mechanisms that govern the cross talks between the LECs and immune cells during homeostasis and inflammation.
    Keywords: R5-920 ; RC581-607 ; Liver Injury ; Lymphatic Vessels ; Lymphatic Vasculature ; Tumor Microenvironment ; PD-L1 ; Antigen Presenting Cells ; Lymphatic Endothelial Cells ; T cell trafficking ; T cells ; bic Book Industry Communication::M Medicine
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  • 59
    Publication Date: 2023-12-21
    Description: Allogeneic haematopoietic stem cell transplantation (allo-HSCT) is widely used in the treatment of haematological malignancies as a form of immunotherapy acting through a graft-versus-leukemia (GvL) reaction. This curative allogeneic response can be associated with severe drawbacks, such as frequent and severe graft-versus-host disease (GvHD) and a long-lasting immunodeficiency, especially now with the development of innovative strategies such as umbilical cord blood transplantation or transplants from haplo-identical family donors (Haplo-HSCT). In the long-term follow-up of these patients, severe post-transplant infections, relapse or secondary malignancies may be directly related to persistent immune defects.Reconstitution of the different lymphocyte populations (B, T, NK, NKT) and antigen presenting cells of myeloid origin (monocytes, macrophages and dendritic cells) should be considered not only quantitatively but especially qualitatively, in terms of functional subsets. Immune deficiency leading to an increased susceptibility to infections lasts for more than a year. Although infections that occur in the first month mostly result from a deficiency in both granulocytes and mononuclear cells (MNC), later post-engraftment infections are due to a deficiency in MNC subsets, primarily CD4 T-cells and B-cells. T-cell reconstitution has been extensively studied because of the central role of T-cells in mediating both GvHD, evidenced by the reduced incidence of this complication following T-Cell depletion, and a GvL effect as shown by DLI. In the recent years there has been renewed interest in the role of NK-cells, especially in the context of Haplo-HSCT, and in B-cell reconstitution.This Frontiers Research Topic will provide state of the art knowledge of the mechanisms of immune reconstitution in an allogeneic environment, in order to improve monitoring and therapeutic intervention in allo-HSCT patients.
    Keywords: R5-920 ; RC581-607 ; cell therapy ; Immune reconstitution ; Haplo-SCT ; HSCT ; Thymic function ; bic Book Industry Communication::M Medicine
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  • 60
    Publication Date: 2023-12-21
    Description: Gamma/delta (γδ) T-cells are a small subset of T-lymphocytes in the peripheral circulation but constitute a major T-cell population at other anatomical localizations such as the epithelial tissues. In contrast to conventional a/ß T-cells, the available number of germline genes coding for T-cell receptor (TCR) variable elements of γδ T-cells is very small. Moreover, there is a prefential localization of γδ T-cells expressing given Vgamma and Vdelta genes in certain tissues. In humans, γδ T-cells expressing the Vg9Vd2-encoded TCR account for anywhere between 50 and 〉95% of peripheral blood γδ T-cells, whereas cells expressing non-Vd2 genes dominate in mucosal tissues. In mice, there is an ordered appearance of γδ T-cell „waves“ during embryonic development, resulting in preferential localization of γδ T-cells expressing distinct VgammaVdelta genes in the skin, the reproductive organs, or gut epithelia. The major function of γδ T-cells resides in local immunosurveillance and immune defense against infection and malignancy. This is supported by the identification of ligands that are selectively recognized by the γδ TCR. As an example, human Vgamma9Vdelta2 T-cells recognize phosphorylated metabolites („phosphoantigens“) that are secreted by many pathogens but can also be overproduced by tumor cells, providing a basis for a role of these γδ T-cells in both anti-infective and anti-tumor immunity. Similarly, the recognition of endothelial protein C receptor by human non-Vdelta2 γδ T-cells has recently been identified to provide a link for the role for such γδ T-cells in immunity against epithelial tumor cells and cytomegalovirus-infected endothelial cells. In addition to „classical“ functions such as cytokine production and cytotoxicity, recent studies suggest that subsets of γδ T-cells can exert additional functions such as regulatory activity and – quite surpisingly – „professional“ antigen-presenting capacity. It is currently not well known how this tremendous extent of functional plasticity is regulated and what is the extent of γδ TCR ligand diversity. Due to their non-MHC-restricted recognition of unusual stress-associated ligands, γδ T-cells have raised great interest as to their potential translational application in cell-based immunotherapy. Topics of this Research Focus include: Molecular insights into the activation and differentiation requirements of γδ T-cells, role of pyrophosphates and butyrophilin molecules for the activation of human γδ T-cells, role of γδ T-cells in tumor immunity and in other infectious and non-infectious diseases, and many others. We are most grateful to all colleagues who agreed to write a manuscript. Thanks to their contributions, this E-book presents an up-to-date overview on many facets of the still exciting γδ T-cells.
    Keywords: R5-920 ; RC581-607 ; Infection ; Butyrophilin 3A1 ; Tumor-infiltrating lymphocytes ; cancer immunotherapy ; IL-17 ; Pyrophosphates ; bic Book Industry Communication::M Medicine
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  • 61
    Publication Date: 2024-04-11
    Description: The specialty section Earthquake Engineering is one branch of Frontiers in Built Environment and welcomes critical and in-depth submissions on earthquake ground motions and their effects on buildings and infrastructures. Manuscripts should yield new insights and ultimately contribute to a safer and more reliable design of building structures and infrastructures. The scope includes the characterization of earthquake ground motions (e.g. near-fault, far-fault, short-period, long-period), their underlying properties, their intrinsic relationship with structural responses, and the true behaviors of building structures and infrastructures under risky and uncertain ground motions. More specific topics include recorded ground motions, generated ground motions, response spectra, stochastic modeling of ground motion, critical excitation, geotechnical aspects, soil mechanics, soil liquefaction, soil-structure interactions, pile foundations, earthquake input energy, structural control, passive control, active control, base-isolation, steel structures, reinforced concrete structures, wood structures, building retrofit, structural optimization, uncertainty analysis, robustness analysis, and redundancy analysis. This eBook includes four original research papers, in addition to the Specialty Grand Challenge article, on the critical earthquake response of elastic-plastic structures under near-fault or long-duration ground motions which were published in the specialty section Earthquake Engineering. In the early stage of dynamic nonlinear response analysis of structures around 1960s, a simple hysteretic structural model and a simple sinusoidal earthquake ground motion input were dealt with together with random inputs. The steady-state response was tackled by an equivalent linearization method developed by Caughey, Iwan and others. In fact, the resonance plays a key role in the earthquake-resistant design and it has a strong effect even in case of near-fault ground motions. In order to draw the steady-state response curve and investigate the resonant property, two kinds of repetition have to be introduced. One is a cycle, for one forced input frequency, of the initial guess of the steady-state response amplitude, the construction of the equivalent linear model, the analysis of the steady-state response amplitude using the equivalent linear model and the update of the equivalent linear model based on the computed steady-state response amplitude. The other is the sweeping over a range of forced input frequencies. This process is quite tedious. Four original research papers included in this eBook propose a new approach to overcome this difficulty. Kojima and Takewaki demonstrated that the elastic-plastic response as continuation of free-vibrations under impulse input can be derived in a closed form by a sophisticated energy approach without solving directly the equations of motion as differential equations. While, as pointed out above, the approach based on the equivalent linearization method requires the repetition of application of the linearized equations, the method by Kojima and Takewaki does not need any repetition. The double impulse, triple impulse and multiple impulses enable us to describe directly the critical timing of impulses (resonant frequency) which is not easy for the sinusoidal and other inputs without a repetitive procedure. It is important to note that, while most of the previous methods employ the equivalent linearization of the structural model with the input unchanged, the method treated in this eBook transforms the input into a series of impulses with the structural model unchanged. This characteristic guarantees high accuracy and reliability even in the large plastic deformation range. The approach presented in this eBook is an epoch-making accomplishment to open the door for simpler and deeper understanding of structural reliability of built environments in the elastic-plastic range.
    Keywords: TA1-2040 ; fling-step input ; Critical response ; Long-duration ground motion ; double impulse ; forward-directivity input ; triple impulse ; robustness ; Near-fault ground motion ; Ground motion ; Ductility factor ; uncertainty ; resonance ; Structural parameter ; Earthquake Response ; Elastic-plastic response ; Interval analysis ; Multiple impulse ; Earthquake input energy ; redundancy ; Upper bound of input energy ; earthquake engineering ; critical excitation method ; Energy transfer function ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology
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  • 62
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    Unknown
    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Epigenetics is the study of changes in gene activity that are heritable but not caused by changes in the DNA sequence. By modulating gene activities, epigenetic changes regulate cell functions. They include DNA methylation, histone posttranslational modifications and gene silencing by the action of non-coding RNAs, particularly microRNAs. It is now clear that epigenetic changes regulate B cell development. By acting in concert with networks of transcription factors, they modulate the activation of B cell lineage specific gene programs and repress inappropriate gene transcription in particular B cell differentiation states. A hallmark of B cell development in the bone marrow is the assembly of the B cell receptor (BCR) for antigen through rearrangement of immunoglobulin heavy (IgH) and light (IgL) chain V(D)J genes, as mediated by RAG1/RAG2 recombinases. Ig V(D)J rearrangement critically times the progression from pro-B cell to pre-B cell and, finally, mature B cell. Such progression is modulated by epigenetic marks, such as DNA methylation and histone posttranslational modifications, that increase chromatin accessibility and target RAG/RAG2 to V, D and J DNA. It is also dependent on the expression of multiple microRNAs. Mice deficient in Ago2, which is essential for microRNA biogenesis and function, have B cell development blocked at the pro-B cell stage. In agreement with this, B cell specific ablation of microRNA by B cell-specific knockout of Dicer virtually blocks B cell differentiation at the pro-B to pre-B cell transition. After mature B cells encounter antigen, changes of the epigenetic landscape are induced by the same stimuli that drive the antibody response; such epigenetic changes underpin the maturation of the antibody response itself. They instruct those B cell differentiation processes, somatic hypermutation (SHM), class switch DNA recombination (CSR) and plasma cell differentiation, that are central to the maturation of the antibody response as well as differentiation of memory B cells. Inducible histone modifications, together with DNA methylation and microRNAs modulate the transcriptome, particularly the expression of activation-induced cytidine deaminase (AID), central to SHM and CSR, and B lymphocyte-induced maturation protein-1 (Blimp-1), which is central to plasma cell differentiation. Combinatorial histone modifications also function as histone codes in the targeting of the CSR and, possibly, the SHM machinery to the Ig locus by recruiting specific adaptors (histone code readers) that can in turn target and/or stabilize CSR/SHM factors. Epigenetic alterations in memory B cells contribute to their functionally distinction from their naive counterparts. Memory B cells inherit epigenetic information from their precursors and acquire new epigenetic marks, which make these resting B cells poised to promptly respond to antigen. The cross/feedback regulation of different epigenetic modifications/elements further increases the complexity of the B cell epigenome, which interacts with the genetic information for precise modulation of gene expression. It is increasingly evident that epigenetic dysregulation in B cells, including aberrant expression of microRNAs, can result in aberrant antibody responses to microbial pathogens, emergence of pathogenic autoantibodies or B cell neoplastic transformation. Epigenetic marks are potential targets for new therapeutics in autoimmunity and B cell malignancy.
    Keywords: R5-920 ; RC581-607 ; BLIMP-1 ; CSR ; immunoglobulin ; memory B cell ; Plasma cell ; V(D)J Recombination ; microRNA ; SHM ; AID ; epigenetics ; bic Book Industry Communication::M Medicine
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  • 63
    Publication Date: 2022-04-28
    Description: Papua New Guinea has a complex ‘law and order’ problem and an entrenched epidemic of HIV. This book explores their interaction. It also probes their joint challenges and opportunities—most fundamentally for civic security, a condition that could offersome immunity to both. This book is a valuable and timely contribution to a limited but growing body of scholarship in the social and structural contexts of HIV epidemiology in Papua New Guinea. The volume offers a unique collection of interdisciplinary insights on the connections between law and order and the HIV epidemic and is presented in a manner accessible to a wide audience, scholars and lay people alike… Significantly, this is the first volume to critically examine the complex and inexorable links between HIV, gender, violence, and security within a theoretical framework thv at illuminates the challenges of the epidemic for PNG’s future cohesion and stability as a young nation…The importance of this courageous book cannot be overstated. While it communicates an urgent and potent message about the need for immediate action … it offers insightful reflections on the processes and possibilities of social transformation that undoubtedly will have enduring scholarly and practical value. Dr Katherine Lepani, Social Foundations of Medicine, The Australian National University.
    Keywords: politics and goverment ; law enforcement ; social conditions ; papua new guinea ; aids ; crime ; hiv infections ; Condom ; HIV/AIDS ; Portable Network Graphics ; Prostitution ; Rape ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::L Law::LA Jurisprudence & general issues::LAQ Law & society
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  • 64
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    Unknown
    Springer Nature | Palgrave Macmillan
    Publication Date: 2021-02-10
    Description: This open access book seeks to understand how politics is being made in a pluralistic sense, and explores how these political struggles are challenging and transforming gender, sexuality, and colonial norms. As researchers located in Sweden, a nation often cited as one of the most gender-equal and LGBTQ-tolerant nations, the contributions investigate political processes, decolonial struggles, and events beyond, nearby, and in between organizations, states, and national territories. The collection represents a variety of disciplines, and different theoretical conceptualizations of politics, feminist theory, and postcolonial and queer studies. Students and researchers with an interest of queer studies, gender studies, critical whiteness studies, and civil society studies will find this book an invaluable resource.
    Keywords: Gender and Sexuality ; Queer Theory ; Politics and Gender ; Culture and Gender ; Gender Studies ; Queer Studies ; Gender and Culture ; communities of belonging ; homonationalism ; femonationalism ; decoloniality ; intersectionality ; transnationalism ; Open Access ; Gender studies, gender groups ; Gay & Lesbian studies ; Politics & government ; Cultural studies ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFS Social groups::JFSJ Gender studies, gender groups ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies
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  • 65
    Publication Date: 2023-12-21
    Description: The recent wave of clinical studies demonstrating long-term therapeutic efficacy highlights the enormous potential of gene therapy as an approach to the treatment of inherited disorders and cancer. While in recent years lentiviral vectors have dominated the field of ex vivo gene therapy in man, adeno-associated virus (AAV) vectors have become the platform of choice for the in vivo gene delivery, both local and systemic.Despite the achievements in the clinic however, a number of hurdles remain to be overcome in gene therapy, these include availability of scalable vector production systems, potential issues associated with insertional mutagenesis, and concerns related to immunogenicity of gene therapeutics. For AAV vectors, clinical trials showed that immunity directed against the vector could either prevent transduction of a target tissue or limit the duration of therapeutic efficacy. Initial observations in the context of a gene therapy trial for hemophilia spurred over a decade efforts by gene therapists and immunologists to understand the mechanism and identify factors that contribute to AAV’s immunogenicity, including the prevalence of B cell and T cell immunity to wild type AAV in humans and the interaction of AAV vectors with the innate and adaptive immune system. Despite a number of important contributions in particular in the more recent past, our knowledge on the immunology of gene transfer is still rudimental; this is partly due to the fact that the basic understanding of the complex balance between tolerance and immunity to an antigen, key aspect of gene transfer with AAV, keeps evolving rapidly. However, continuing work towards a better definition of the interaction of viral vectors with the immune system has led to significant advances in the knowledge of the factors influencing the outcome of gene transfer, such as the vector dose, the immune privilege of certain tissues, and the induction of tolerance to an antigen. A better understanding of the structure-function relationship of the viral capsid has boosted the development of novel immune-escape vector variants. In addition, novel immunomodulatory strategies were established to prevent or reduce anti-capsid immunity have been developed and are being tested in preclinical models and in clinical trials. Together, these advances are bringing us closer to the goal of achieving safe and sustained therapeutic gene transfer in humans. In this research topic, a collection of Original Research and Review Articles highlights critical aspects of the interaction between gene AAV vectors and the immune system, discussing how these interactions can be either detrimental or constitute an advantage, depending on the context of gene transfer, and providing tools and resources to better understand the issue of immunogenicity of AAV vectors in gene transfer.
    Keywords: R5-920 ; RC581-607 ; antibody response ; Clinical Trial ; Gene Therapy ; Regulatory T Cell ; Immunomodulation ; Tolerance induction ; adaptive and innate immunity ; adeno-associated virus ; Vaccine ; Epitopes ; bic Book Industry Communication::M Medicine
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  • 66
    Publication Date: 2023-12-21
    Description: CD4+ T lymphocytes play an essential role in host defense against bacterial, parasitic and viral infections. During infection, under the influence of intrinsic signals received through peptide-MHC/TCR interactions and extrinsic signals provided by pathogen-conditioned dendritic and other accessory cells, CD4+ T cells proliferate and differentiate into specialized T helper (Th) effectors, which produce distinct sets of cytokines tailored to combat a specific class of microbes. The concept of CD4+ T cell multi-functionality was developed after the seminal discovery of Th1 and Th2 cells nearly 30 years ago. Although the Th1/Th2 paradigm has successfully withstood the test of time, in the past decade additional Th subsets (Th17, Tfh, Th22, Th9) have been identified. Similarly, single cell analyses of cytokines and master transcriptional factors have revealed that, at the population level, CD4+ T cell responses are far more heterogeneous than initially anticipated. While some of the checkpoints in Th cell specification have been identified, recent studies of transcriptional and epigenetic regulation have uncovered a significant flexibility during the course CD4+ T lymphocyte polarization. In addition, Th cells expressing cytokines with counteracting functions, as a measure of self-regulation, display yet another level of diversity. Understanding the mechanisms that control the balance between stability vs. plasticity of Th effectors both at the time of initiation of immune response and during development of CD4 T cell memory is critical for the rational design of better vaccines and new immunotherapeutic strategies. This research topic will cover current views on Th cell development, with a focus on the mechanisms that govern differentiation, function and regulation of effector Th cells in the context of microbial infections.
    Keywords: R5-920 ; RC581-607 ; Infection ; Dendritic Cells ; Cytokines ; Immunoregulation ; CD4 lymphocytes ; Memory ; long noncoding RNA ; Macrophages ; Metabolism ; Th1 Th2 ; bic Book Industry Communication::M Medicine
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  • 67
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    Unknown
    Bloomsbury Academic
    Publication Date: 2024-02-15
    Description: Chapter 8 shows the connection between a certain vision of citizenship – in this context, ethnonationally defined – and violence, and how citizenship is crucial though under-researched trigger of violence. To examine why and how this violence happened, and what was the role of citizenship, the chapter examines the whole post-socialist post-partition European states. It argues that the fate of many citizens of the former socialist federations in the context of their imminent disintegration was determined by their answers to the following questions: Did the incipient states (republics) and the federal centre accept the separation and the existing borders? Did all groups and all regions accept independence and the authorities of the new states? The analysis of the possible answers to these questions across post-socialist Europe brings us to three decisive triggers of violence: citizenship, borders and territories, and, finally in the early 1990s, the role of the military apparatus of defunct federations. One could safely conclude that there is an intimate historic affinity between citizenship and war. From the antique city-states where full citizenship status was acquired by serving in war (Anderson 1996: 28, 33; Pocock 1998), via the traditional military draft for men (and in some places for women) to contemporary practices that enable immigrants and foreigners serving in the armed forces, such as the US army or in the Légion étrangère, an easier access to citizenship. There is a historic relationship between ‘blood’, either inherited or spilled (one’s own or of other people), and citizenship. However, violence related to citizenship is not only physical but often invisible. It is the violence of administrative decisions, hierarchy of different statuses, ‘wrong’ passports and ‘papers’ or deprivations of citizenship. In the following chapter, I will also tackle the issue of physically invisible but nonetheless effective violence caused by the post-Yugoslav citizenship regimes. In this chapter though, I will turn to the outbreak of that ‘visible’ violence that spread across almost all corners of the former Yugoslavia. To examine why and how this violence happened, and what was the role of citizenship, we need to cast the net more widely all over post-socialist post-partition European states.
    Keywords: citizenship ; post-socialist europe ; violence ; borders ; 1989 ; territories ; disintegration ; ethnic conflicts ; federal armies ; citizenship ; post-socialist europe ; violence ; borders ; 1989 ; territories ; disintegration ; ethnic conflicts ; federal armies ; Croatia ; Kosovo ; Russia ; Serbia ; Serbia and Montenegro ; Serbs ; Serbs of Bosnia and Herzegovina ; Transnistria ; Yugoslav People's Army ; bic Book Industry Communication::J Society & social sciences ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
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  • 68
    Publication Date: 2023-12-21
    Description: Lipids are best known as energy storing molecules and core-components of cellular membranes, but can also act as mediators of cellular signaling. This is most prominently illustrated by the paramount importance of the phospholipase C (PLC) and phosphoinositide 3-kinase (PI3K) signaling pathways in many cells, including T cells and cancer cells. Both of these enzymes use the lipid phosphatidylinositol(4,5)bisphosphate (PIP2) as their substrate. PLCs produce the lipid product diacylglycerol (DAG) and soluble inositol(1,4,5)trisphosphate (IP3). DAG acts as a membrane tether for protein kinase C and RasGRP proteins. IP3 is released into the cytosol and controls calcium release from internal stores. The PI3K lipid product phosphatidylinositol(3,4,5)trisphosphate (PIP3) controls signaling by binding and recruiting effector proteins such as Akt and Itk to cellular membranes. Recent research has unveiled important signaling roles for many additional phosphoinositides and other lipids. The articles in this volume highlight how multiple different lipids govern T cell development and function through diverse mechanisms and effectors. In T cells, lipids can orchestrate signaling by organizing membrane topology in rafts or microdomains, direct protein function through covalent lipid-modification or non-covalent lipid binding, act as intracellular or extracellular messenger molecules, or govern T cell function at the level of metabolic regulation. The cellular activity of certain lipid messengers is moreover controlled by soluble counterparts, exemplified by symmetric PIP3/inositol(1,3,4,5)tetrakisphosphate (IP4) signaling in developing T cells. Not surprisingly, lipid producing and metabolizing enzymes have gained attention as potential therapeutic targets for immune disorders, leukemias and lymphomas.
    Keywords: R5-920 ; RC581-607 ; eicosanoid ; Inositol ; diacylglyerol ; PI3K ; Vitamin D ; T cell ; SHIP ; Pten ; Adipokine ; Lipid ; bic Book Industry Communication::M Medicine
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  • 69
    Publication Date: 2024-03-30
    Description: Nuclear Engineering; Environmental Science and Engineering; Social Sciences, general
    Keywords: Nuclear Engineering ; Environmental Science and Engineering ; Social Sciences, general ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNR Natural disasters ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TN Civil engineering, surveying and building::TNK Building construction and materials::TNKX Conservation of buildings and building materials
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  • 70
    Publication Date: 2023-12-21
    Description: Schistosomiasis is a severe parasitic disease, endemic in 74 developing countries with up to 600 million people, including many children, infected and 800 million at risk of contracting the disease following infection with Schistosoma mansoni, S. haematobium or S. japonicum. Disease burden is estimated to exceed 70 million disability-adjusted life-years, and leads to remarkably high YLD (years lived with disability) rates. Even more importantly, people with schistosomiasis are highly susceptible to malaria, tuberculosis and hepatic and acquired immunodeficiency viruses. There is only one drug, praziquantel, currently available for treatment and it has high efficacy, low cost, and limited side effects. However, only 13% of the target population has received the drug, and those treated are at continuous risk of reinfection necessitating repeated drug administration and the emergence of drug resistant parasites is a constant threat. There currently is no vaccine. While the target of 〉40% protection has been achieved with some molecules such as excretory-secretory proteins including calpain, glyceraldehyde 3-phosphate dehydrogenase, and cysteine peptidases, very recent articles reiterate the findings published during the last 2 decades of the last century, contradicting the established data of the pioneers of schistosome biology. A consensus should be reached without delay, in order to propose collaborative independent experiments and proceed ahead to pre- and clinical trials with efficacious candidate vaccine molecules. The proposed plan aims to finally reach an objective and fruitful agreement , via inviting established and young researchers from the United States, Brazil, China, Australia, and Europe who are working with different vaccine antigens, adjuvants, and approaches for immunization against S. mansoni, S. haematobium, and S. japonicum. It is hoped that the forum will end with a very few candidate antigens and a consensus approach regarding target immune responses, thus leading to encouraging the World Health Organization and other international foundations to sponsor the development and implementation of the urgently required, yet still elusive, vaccine for preventing and eliminating the transmission of schistosomiasis.
    Keywords: R5-920 ; RC581-607 ; Schistosomiasis ; Schistosoma mansoni ; Schistosoma haematobium ; Type 2 cytokines ; Vaccine ; Immune responses ; Schistosoma japonicum ; Vaccine candidates ; bic Book Industry Communication::M Medicine
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  • 71
    Publication Date: 2022-04-28
    Description: This volume of the Peacebuilding Compared Project examines the sources of the armed conflict and coup in the Solomon Islands before and after the turn of the millennium. The Regional Assistance Mission to Solomon Islands (RAMSI) has been an intensive peacekeeping operation, concentrating on building ‘core pillars’ of the modern state. It did not take adequate notice of a variety of shadow sources of power in the Solomon Islands, for example logging and business interests, that continue to undermine the state’s democratic foundations. At first RAMSI’s statebuilding was neither very responsive to local voices nor to root causes of the conflict, but it slowly changed tack to a more responsive form of peacebuilding. The craft of peace as learned in the Solomon Islands is about enabling spaces for dialogue that define where the mission should pull back to allow local actors to expand the horizons of their peacebuilding ambition.
    Keywords: ethnic conflict ; politics and government ; solomon islands ; history ; peace building ; Guadalcanal ; Honiara ; Peacebuilding ; Regional Assistance Mission to Solomon Islands ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTJ Peace studies & conflict resolution ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 72
    Publication Date: 2023-12-21
    Description: Natural antibodies (NAbs) are found in normal individuals in the absence of exogenous antigenic stimulation. Natural antibodies rapidly recognize and protect against pathogens that have not been previously encountered. NAbs also cross-react with several self-antigens, which, besides their role as a first line of defense against pathogens, affords them the ability to perform important housekeeping functions in healthy organisms. Such housekeeping functions include the clearance of oxidized damaged structures and/or apoptotic cells, which prevents the induction of pro-inflammatory effects. In addition, NAbs play a role in preventing the expansion of specific auto-reactive clones, thereby behaving as regulatory elements in acute or chronic inflammation. To maintain the non-pathogenic balance between the dual pathogen/self-antigen cross-reactivities of NAbs, a strict regulation in NAb secretion and function is necessary to avoid autoimmune disease. Actually, some of the NAbs related auto-reactivities, such as anti-DNA and anti-MOG, have been associated with autoimmunity. Furthermore, NAbs have been shown to bind to ‘neo-self’ carbohydrate antigens on glycolipids and glycoproteins found on malignant but not normal cells, which suggests NAbs may take part in tumor immunosurveillance. Many aspects regarding NAbs have yet to be studied in more detail: the reactivity and function of NAbs in health and disease, the behavior of the NAb repertoire with increasing age, the regulation of natural antibody production and auto-reactivity, the ways to specifically activate NAbs producing cells with desired specificities, the characteristics of human NAbs, among others. This special topics eBook consists of a number of articles exploring the cells that produce NAbs as well as the characteristics, function, specificity, and/or the role of natural antibodies in health and disease.
    Keywords: R5-920 ; RC581-607 ; innate immunity ; immunoglobulin ; Antibodies ; B cells ; IgM ; natural antibodies ; B-1 cells ; bic Book Industry Communication::M Medicine
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  • 73
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: In the highly competitive world of biomedical science, often the rush to publish and to be recognized as "first" with a new discovery, concept or method, is lost in the hurly-burly of the moment, as "the maddening crowd" moves on to the next "new thing". One of the great things about immunology today is that it has only become mature as a science within the last half-century, and especially within the past 35 years as a consequence of the revolution of molecular immunology, which has taken place only since 1980. Consequently, most of those who have contributed to our new understanding of how the immune system functions are still alive and well, and still contributing. Thus, "A Living History of Immunology" collates many stories from the investigators who actually performed the experiments that have established the frontiers of immunology. Accordingly, this volume combats "revisionist science", by those who want to alter history by telling the stories a different way than actually happened. In this regard, one of the good things about science vs. other disciplines is that we have the written record of what was done, when it was done and by whom. Even so, we do not have the complete story or narrative of how and why experiments were done, and what made the differences that led to success. This volume captures and chronicles some of these stories from the past fifty years in immunology.
    Keywords: R5-920 ; RC581-607 ; cytotoxic T lymphocytes (CTL) ; antibody ; Interleukins ; immunology history ; B cells ; Macrophages ; T cells ; Antibody Forming Cells (AFC) ; Thymus ; T cell receptor (TCR) ; bic Book Industry Communication::M Medicine
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  • 74
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    Springer Nature | Springer
    Publication Date: 2021-02-10
    Description: This open access book assembles landmark studies on divorce and separation in European countries, and how this affects the life of parents and children. It focuses on four major areas of post-separation lives, namely (1) economic conditions, (2) parent-child relationships, (3) parent and child well-being, and (4) health. Through studies from several European countries, the book showcases how legal regulations and social policies influence parental and child well-being after divorce and separation. It also illustrates how social policies are interwoven with the normative fabric of a country. For example, it is shown that father-child contact after separation is more intense in those countries which have adopted policies that encourage shared parenting. Correspondingly, countries that have adopted these regulations are at the forefront of more egalitarian gender role attitudes. Apart from a strong emphasis on the legal and social policy context, the studies in this volume adopt a longitudinal perspective and situate post-separation behaviour and well-being in the life course. The longitudinal perspective opens up new avenues for research to understand how behaviour and conditions prior or at divorce and separation affect later behaviour and well-being. As such this book is of special appeal to scholars of family research as well as to anyone interested in the role of divorce and separation in Europe in the 21st century.
    Keywords: Life course ; Population Economics ; Quality of Life Research ; Sociology of Family, Youth and Aging ; European Politics ; Life Course ; Open access ; Separation ; Divorce ; Well-being ; Parent-child relationships ; post-separation families ; Parental and Child well-being ; economic conditions after divorce ; Sociology ; Political economy ; Population & demography ; Personal & public health ; Public health & preventive medicine ; Sociology: family & relationships ; Politics & government ; Europe ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology ; bic Book Industry Communication::K Economics, finance, business & management::KC Economics::KCP Political economy ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine::MBNH Personal & public health ; bic Book Industry Communication::J Society & social sciences::JH Sociology & anthropology::JHB Sociology::JHBK Sociology: family & relationships ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
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  • 75
    Publication Date: 2023-12-21
    Description: Immune molecules have evolved to distinguish “self “molecules from “non-self”, “altered self” and “danger” molecules. Recognition is mediated via interactions between pattern recognition receptor molecules (PPRs) and their ligands, which include hydrophobic and electrostatic interactions between amino acid residues on the PPRs and uncharged or charged groups on amino acid residues, sugar rings or DNA/RNA molecules. Recognition in innate immunity range from cases (C1q, mannin-binding protein etc) where recognition is orchestrated by interaction between many ligands with one receptor molecule, and density of interaction is necessary for strong specific recognition, distinct from weak non-specific binding, and cases such as TLRs and NLRs where recognition involves complexation of single receptor and ligand, followed by oligomerisation of the receptor molecule. The majority of PPR molecules bind and recognise a wide variety of ligands, e.g TLR4 recognises LPS (gram negative bacteria), Lipotechoic acid (gram positive bacteria), heat shock protein hsp60, respiratory syncytial virus fusion protein etc, molecules that are structurally dissimilar to each other. This indicates considerable flexibility in their binding domains (amino acid residue variations) and modes (hydrophobic and charged, direct or mediated via an adaptor molecule). However, in many cases there is a dearth of structural and molecular data available, required to delineate the mechanism of ligand binding underlining recognition in pathogen receptors in innate immunity. Insights into requirements of conformation, charge, surface etc in the recognition and function of innate immunity receptors and their activation pathways, based on current data can suggest valuable avenues for future work.
    Keywords: R5-920 ; RC581-607 ; HIV-1 ; host-pathogen interactions ; zebrafish model system ; innate immunity ; protein-protein interaction ; complement ; malaria ; pattern recognition ; bic Book Industry Communication::M Medicine
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  • 76
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2021-02-10
    Description: This open access book provides an in-depth look into the background of rule of law problems and the open defiance of EU law in East Central European countries. Current illiberal trends and anti-EU politics have the potential to undermine mutual trust between member states and fundamentally change the EU. It is therefore crucial to understand their domestic causes, context conditions, specific processes and consequences. This volume contributes to empirically informed theory-building and includes contributions from researchers from various disciplines and multiple perspectives on illiberal trends and anti-EU politics in the region. The qualitative case studies, comparative works and quantitative analyses provide a comprehensive picture of current societal, political and institutional developments in the Czech Republic, Hungary, Poland and Slovakia. Through studying similarities and differences between East Central European and other EU countries, the chapters also explore whether there are regional patterns of democracy- and EU-related problems.
    Keywords: European Politics ; Comparative Politics ; Constitutional Law ; Open Access ; European Union politics ; European integration ; illiberal politics ; backsliding ; democracy ; East Central Europe ; rule of law ; EU law violations ; EU enlargement ; Politics & government ; Europe ; Constitutional & administrative law: general ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPB Comparative politics ; bic Book Industry Communication::L Law::LN Laws of Specific jurisdictions::LND Constitutional & administrative law
    Language: English
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  • 77
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    Springer Nature | Springer
    Publication Date: 2021-02-10
    Description: This open access book features various studies on democratization, transformation, political and economic development, and security issues in the Organization for Security and Cooperation in Europe (OSCE) geographical region and beyond. Written by experts and academics in the fields of human rights, security, transformation and development, particularly in post-soviet and communist countries, it examines the status quo of regime development in various member states of the OSCE; their economic, security and human rights performance; institutional reforms and transformations and the challenges that these countries and their societies face, including the USA, Canada, Germany, Macedonia, Russia, Turkey, Kazakhstan, Kyrgyzstan and Mongolia. This is the 2019 edition of this Compilation Series of the OSCE Academy. The OSCE works to promote Minority Protection, Security, Democratic Development and Human Rights guided by the Office for Democratic Institutions and Human Rights (ODIHR), and to enhance securitization and development policies in Eurasia, Europe, Central Asia and North America. Since being founded in 1993, the OSCE and its agencies and departments have attracted a wealth of academic research in various fields and disciplines, ranging from economic development and election monitoring to enhancing global principles of human rights and securitization. About the OSCE Academy in Bishkek: Founded in 2004, the Academy offers post-Doc research fellowships and runs two Master Degrees, one in Economic Governance and Development and one in Politics and Security in Central Asia. The Academy"s regular academic programs and conference contributes to developing human professional capital in the sectors of particular importance for Central Asian states and societies. The Academy's graduates and visiting researchers contribute to economic development, governance and policy-making in Central Asia and beyond the OSCE region. Website: http://www.osce-academy.net/en/about/
    Keywords: Regional Development ; Social Justice, Equality and Human Rights ; International Security Studies ; Development Policy ; Democracy ; Organization for Security and Cooperation ; Regime transformation ; Securitization policies ; Democratization ; Human Rights ; Belt and Road Initiative ; Autocracies ; Transformation studies ; Open Access book ; New Silk Road ; Development studies ; Politics & government ; International relations ; Political structures: democracy ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPH Political structure & processes::JPHV Political structures: democracy
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  • 78
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    Springer Nature
    Publication Date: 2024-03-30
    Description: Emerging Markets/Globalization; Innovation/Technology Management; Business Strategy/Leadership; International Economics; Operations Management
    Keywords: Emerging Markets/Globalization ; Innovation/Technology Management ; Business Strategy/Leadership ; International Economics ; Operations Management ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJC Business strategy ; thema EDItEUR::K Economics, Finance, Business and Management::KJ Business and Management::KJM Management and management techniques::KJMV Management of specific areas ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KNB Energy industries and utilities ; thema EDItEUR::K Economics, Finance, Business and Management::KN Industry and industrial studies::KND Manufacturing industries ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TB Technology: general issues::TBX History of engineering and technology ; thema EDItEUR::T Technology, Engineering, Agriculture, Industrial processes::TC Biochemical engineering ; thema EDItEUR::W Lifestyle, Hobbies and Leisure::WC Antiques, vintage and collectables::WCF Collecting coins, banknotes, medals and other related items
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  • 79
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Signaling through the cell surface antigen receptor is a hallmark of various stages of lymphocyte development and adaptive immunity. Besides the adaptive immune system, the innate immunity is equally important for protection. However, the mechanistic connection between signaling, chromatin changes and downstream transcriptional pathways in both innate and adaptive immune system remains incompletely understood in hematopoiesis. A related issue is how the enhancers communicate to the promoters in a stage specific fashion and in the context of chromatin. Because the factors that regulate chromatin are generally present and active in most cell types, how could cell type and/or stage specific chromatin architecture is achieved in response to a particular immune signal?The genetic loci that encode lymphocyte cell surface receptors are in an "unrearranged” or “germline” configuration during the early stages of development. Thus, in addition to expressing lineage and/or stage specific transcription factors during each developmental stage, lymphocytes also need to rearrange their cognate receptor loci in a strictly ordered fashion. Hence, there must be a tightly coordinated communication between the recombination machinery and the transcriptional machinery (including chromatin regulators) at every developmental step. Mature B cells also undergo classswitch recombination and somatic hypermutation. Importantly, along the way, these cells must avoid autoimmune responses and only those cells capable of recognizing foreignantigens are preserved to reach peripheral organs where they must function. The exquisite regulation that govern chromatin accessibility, recombination and transcription regulation in response to the environmental signals in the immune system is discussed here is a series of articles.
    Keywords: R5-920 ; RC581-607 ; Promoter ; Chromatin ; transcription ; Enhancer ; immune response ; bic Book Industry Communication::M Medicine
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  • 80
    Publication Date: 2023-12-21
    Description: More than 90% of diseases possess immunological abnormalities. Disorders such as inflammation, hypersensitivity, autoimmunity and immunodeficiency are simple examples of how the immune system misinterprets its surroundings and goes awry. Multiple sclerosis, rheumatoid arthritis, systemic lupus erythematosus, inflammatory bowel diseases, among many others are manifestations of immune cells attacking normal tissues. On the other hand, damping the immune system leads to diseases such as cancer, AIDS, and severe combined immunodeficiency. The last ten years witnessed an explosion in developing drugs that target the immune system. Several novel monoclonal antibodies have been approved for treatment of various diseases confirming that personalized medicine approach is robust in combating diseases. Hence, the future holds great promise for using personalized and targeted medicine rather than generalized medications that, in most circumstances, proven to be ineffective and characteristically exert side effects. Approaches such as generating novel adjuvants that can stimulate the immune system without harmful side effects, targeting inflammatory cytokines and chemokines, harnessing and activating innate immune cells such as natural killer cells or dendritic cells, are examples of future approaches to treat autoimmune diseases, AIDS, and various forms of cancer resulting from chronic inflammation. More recently, targeting immune checkpoint molecules have shown therapeutic response against lung cancer and melanoma. Identifying molecules involved in autophagy is another example of how personalized medicine might help treat patients with refractory asthma and autoimmune diseases. This topic introduces the reader to these novel approaches of manipulating the immune system and developing targeted therapeutic strategies for treatment of various diseases.
    Keywords: R5-920 ; RC581-607 ; Drugs ; Multiple sclerosis ; NK cells ; Leukemia ; AIDS ; Adjuvants ; Lymphoma ; Autophagy ; Chemokines ; Cancer ; bic Book Industry Communication::M Medicine
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  • 81
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    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.
    Keywords: R5-920 ; RC581-607 ; B cell ; PI3K/AKT/mTOR ; Signal Transduction ; T cell ; PI3K pathway inhibitors ; bic Book Industry Communication::M Medicine
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  • 82
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    Springer Nature | Springer
    Publication Date: 2021-02-10
    Description: This Open Access book is about the development of a common understanding of environmental citizenship. It conceptualizes and frames environmental citizenship taking an educational perspective. Organized in four complementary parts, the book first explains the political, economic and societal dimensions of the concept. Next, it examines environmental citizenship as a psychological concept with a specific focus on knowledge, values, beliefs and attitudes. It then explores environmental citizenship within the context of environmental education and education for sustainability. It elaborates responsible environmental behaviour, youth activism and education for sustainability through the lens of environmental citizenship. Finally, it discusses the concept within the context of different educational levels, such as primary and secondary education in formal and non-formal settings. Environmental citizenship is a key factor in sustainability, green and cycle economy, and low-carbon society, and an important aspect in addressing global environmental problems. It has been an influential concept in many different arenas such as economy, policy, philosophy, and organizational marketing. In the field of education, the concept could be better exploited and established, however. Education and, especially, environmental discourses in science education have a great deal to contribute to the adoption and promotion of environmental citizenship.
    Keywords: Science Education ; Sustainable Development ; Social Justice, Equality and Human Rights ; Environmental and Sustainability Education ; Environmental Social Sciences ; Human Rights ; Sustainability / sustainable development ; Environmental citizenship ; Environmental citizen ; Environmental education ; Education for environmental citizenship ; Education for sustainability ; ENEC ; EU Horizon 2020 ; EU-roadmap 2050 ; European Network for Environmental Citizenship ; Environmental Behavior ; Environmental citizenship from educational perspective ; Open Access ; Teaching of a specific subject ; Science: general issues ; Sustainability ; Politics & government ; Education ; bic Book Industry Communication::J Society & social sciences::JN Education::JNU Teaching of a specific subject ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNU Sustainability ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JN Education
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  • 83
    Publication Date: 2023-12-21
    Description: The immune system employs TLOs to elicit highly localized and forceful responses to unresolvable peripheral tissue inflammation. Current data indicate that TLOs are protective but they may also lead to collateral tissue injury and serve as nesting places to generate autoreactive lymphocytes. A better comprehension of these powerhouses of disease immunity will likely facilitate development to unprecedented and specific therapies to fight chronic inflammatory diseases.
    Keywords: R5-920 ; RC581-607 ; Autoimmunity ; nonresolving peripheral tissue inflammation ; Autoinflammation ; Tertiary lymphoid organs ; dichotomies of immune responses ; disease immunity ; Immune Tolerance ; antigen ; bic Book Industry Communication::M Medicine
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  • 84
    Publication Date: 2023-12-21
    Description: The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies.
    Keywords: R5-920 ; RC581-607 ; cytoskeleton dynamics ; intracellular signalling ; Immunological Synapse ; endosomal dynamics ; bic Book Industry Communication::M Medicine
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  • 85
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    Springer Nature | Springer Fachmedien Wiesbaden
    Publication Date: 2024-03-29
    Description: This edited volume is an open access title and assembles both the historical consciousness and transformation of the MENA region in various disciplinary and topical facets. At the same time, it aims to go beyond the MENA region, contributing to critical debates on area studies while pointing out transregional and cultural references in a broad and comparative manner.
    Keywords: Middle Eastern Politics ; African Politics ; International Relations ; Middle Eastern Culture ; Peace and Conflict Studies ; Middle East ; North Africa ; Middle East and North Africa ; Cultures ; Revolution ; Transregional ; Politics ; Reconfigurations ; MENA Region ; Open Access ; Politics & government ; Africa ; Cultural studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPS International relations ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFC Cultural studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government::JPS International relations ; thema EDItEUR::J Society and Social Sciences::JB Society and culture: general::JBC Cultural and media studies::JBCC Cultural studies
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  • 86
    Publication Date: 2023-12-21
    Description: The pathogenic mechanisms underlying primary T-cell disorders are mainly related to molecular alterations of genes whose expression is intrinsic to hematopoietic cells. However, since the differentiation process requires a crosstalk among thymocytes and the thymic microenvironment, molecular alterations of genes, involved in the differentiation and functionality of the stromal component of the thymus, may lead to a severe T-cell defect or failure of central tolerance, as well. The first example of severe combined immunodeficiency (SCID) not related to an intrinsic alteration of the hematopoietic cell but rather of the thymic epithelial component is the Nude/SCID phenotype, inherited as an autosomal recessive disorder, whose hallmarks are the T-cell defect and the absence of the thymus. The clinical and immunological phenotype is the human equivalent of the murine Nude/SCID syndrome, which represents the first spontaneous SCID identified in nude mice in 1966. For over 3 decades studies of immune system in these mice enormously contributed to the overall knowledge of cell mediated immunity, in the assumption that the athymia of these mice was solely responsible for the T-cell immunological defect. This syndrome is due to mutations of the transcription factor FOXN1, belonging to the forkhead-box gene family, which is mainly expressed in the thymus and skin epithelial cells, where it plays a critical role in differentiation and survival. An alteration of the thymic structure is also a feature of the DiGeorge syndrome (DGS), which has been long considered the human counterpart of the nude mice phenotype. This syndrome is frequently associated to a deletion of the 22q11 region, which contains approximately 30 genes, including the TBX1 gene, which is responsible for most of the clinical features of DGS in humans and mice. In this syndrome common manifestations are cardiac malformations, speech delay, hypoparathyrodism and immunodeficiency, even though the immunological hallmarks of the T-cell defect in DiGeorge syndrome are profoundly different from those reported in human Nude/SCID. The divergence of the phenotype among these 2 entities raised the possibility that the FOXN1 transcription factor represents the real key stromal molecule implicated in directing the hematopoietic stem cell toward a proper T-cell fate. Thymic stromal component of the primary lymphoid organ is also required to negatively select the autoreactive clones, a process driven by the expression of tissue specific antigens (TSA) by medullary thymic epithelial cells (mTECs). The expression of genes encoding TSA antigens is mediated by autoimmune regulator (AIRE) gene, encoding a transcription factor expressed in mTECs. Molecular alterations of this gene are associated to autoimmune polyendocrinopathy candidiasis ectodermal dystrophy (APECED), a rare autosomal disorder, which may be considered the prototype of an autoimmune disease due to the failure of central tolerance homeostasis. All these "experiments of nature" led to unravel novel pathogenic mechanisms underlying inherited disorders of immune system and, of note, to clarify the pivotal role of epithelial cells in the maturation and education process of T-cell precursors.
    Keywords: R5-920 ; RC581-607 ; Central Tolerance ; Rag defects ; Combined immunodeficiency ; DiGeorge Syndrome ; Foxn1 ; medullary thymic epithelial cells ; APECED ; bic Book Industry Communication::M Medicine
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  • 87
    Publication Date: 2023-12-21
    Description: In multicellular organisms, states with a high degree of tissue turnover like embryogenesis, development, and adult tissue homeostasis need an instantaneous, tightly regulated and immunologically silent clearance of these dying cells to ensure appropriate development of the embryo and adult tissue remodelling. The proper and swift clearance of apoptotic cells is essential to prevent cellular leakage of damage associated molecular patterns (DAMPs) which would lead to the stimulation of inflammatory cytokine responses. In addition to the clearance of apoptotic cells (efferocytosis), backup mechanisms are required to cope with DAMPs (HMGB-1, DNA, RNA, S100 molecules, ATP and adenosine) and other intracellular material (uric acid, intracellular proteins and their aggregates) released from cells, that were not properly cleared and have entered the stage of secondary necrosis. Furthermore, under certain pathologic conditions (e.g. gout, cancer, diabetes) non-apoptotic cell death may transiently occur (NETosis, necroptosis, pyroptosis) which generates material that also has to be cleared to avoid overloading tissues with non-functional cellular waste. Efficient efferocytosis is therefore indispensable for normal tissue turnover and homeostasis. The characterization of various signalling pathways that regulate this complex and evolutionary conserved process has shed light on new pathogenetic mechanisms of many diseases. Impaired clearance promotes initiation of autoimmunity as well as the perpetuation of chronic inflammation, but may also foster anti-tumor immunity under certain microenvironmental conditions. Immunological tolerance is continuously being challenged by the presence of post-apoptotic remnants in peripheral lymphoid tissues. Besides the autoimmune phenotype of chronic inflammatory rheumatoid disorders a plethora of pathologies have been associated with defects in genes involved in clearance, e.g. atherosclerosis, cancer, gout, diabetes, some forms of blindness, neuropathy, schizophrenia and Alzheimer’s disease. The main goal of this research topic is to collect contributions from various disciplines committed to studying pathogenetic mechanisms of the aforementioned disorders and dealing with alterations in the clearance of dying and dead cells, their remnants, and their constituents that leak out after membrane rupture. Integrating the combined collection of knowledge on efferocytosis and clearance of dead cells and their derived waste from different fields of research in physiology and pathophysiology could improve the molecular understanding of these increasingly prevalent diseases and may ultimately result in new therapeutic strategies.
    Keywords: R5-920 ; RC581-607 ; Autoimmunity ; NETs ; Efferocytosis ; Inflammation ; cell-remnants ; Phagocytosis ; Apoptosis ; Cancer ; Asthma ; bic Book Industry Communication::M Medicine
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  • 88
    Publication Date: 2024-03-31
    Description: Recognition and killing of aberrant, infected or tumor targets by Natural Killer (NK) cells is mediated by positive signals transduced by activating receptors upon engagement of ligands on target surface. These stimulatory pathways are counterbalanced by inhibitory receptors that raise NK cell activation threshold through negative antagonist signals. While regulatory effects are necessary for physiologic control of autoimmune aggression, they may restrain the ability of NK cells to activate against disease. Overcoming this barrier to immune surveillance, multiple approaches to enhance NK-mediated responses are being investigated since two decades. Propelled by considerable advances in the understanding of NK cell biology, these studies are critical for effective translation of NK-based immunotherapy principles into the clinic. In humans, dominant inhibitory signals are transduced by Killer Immunoglobulin Like Receptors (KIR) recognizing cognate HLA class I on target cells. Conversely, KIR recognition of “missing self-HLA” - due to HLA loss or HLA/ KIR mismatch - triggers NK-mediated tumor rejection. Initially observed in murine transplant models, these antitumor effects were later found to have important implications for the clinical outcome of haplotype-mismatched stemcell transplantation. Here, donor NK subsets protect against acute myeloid leukemia (AML) relapse through missing self recognition of donor HLA-C allele groups (C1 or C2) and/or Bw4 epitope. These studies were subsequently extended by trials investigating the antileukemia effects of adoptively transferred haplotype-mismatched NK cells in non-transplant settings. Other mechanisms have been found to induce clinically relevant NK cell alloreactivity in transplantation, e.g., post-reconstitution functional reversal of anergic NK cells. More recently, activating KIR came into the spotlight for their potential ability to directly activate donor NK cells through in vivo recognition of HLA or other ligands. Novel therapeutic monoclonal antibodies (mAb) may optimize NK-mediated effects. Examples include obinutuzumab (GA101), a glyco-engineered anti-CD20 mAb with increased affinity for the FcγRIIIA receptor, enhancing antibody-dependent cellular cytotoxicity; lirilumab (IPH2102), a first-in-class NK-specific checkpoint inhibitor, blocking the interaction between the major KIR and cognate HLA-C antigens; and elotuzumab (HuLuc63), a humanized monoclonal antibody specific for SLAMF7, whose anti-myeloma therapeutic effects are partly due to direct activation of SLAMF7-expressing NK cells. In addition to conventional antibodies, NK cell-targeted bispecific (BiKEs) and trispecific (TriKEs) killer engagers have also been developed. These proteins elicit potent effector functions by binding target ligands (e.g., CD19, CD22, CD30, CD133, HLA class II, EGFR) on one arm and NK receptors on the other. An additional innovative approach to direct NK cell activity is genetic reprogramming with chimeric antigen receptors (CAR). To date, primary NK cells and the NK92 cell line have been engineered with CAR specific for antigens expressed on multiple tumors. Encouraging preclinical results warrant further development of this approach. This Research Topic welcomes contributions addressing mechanisms of NK-mediated activation in response to disease as well as past and contemporary strategies to enhance NK mediated reactivity through control of the interactions between NK receptors and their ligands.
    Keywords: R5-920 ; RC581-607 ; Natural Killer cells ; Checkpoint inhibitors ; Immune Evasion ; Immunotherapy ; Transplantation ; chimeric antigen receptors ; Nk receptors ; bispecific antibodies ; Cancer ; thema EDItEUR::M Medicine and Nursing
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  • 89
    Publication Date: 2023-12-21
    Description: Successful containment of an infection is dependent on both innate and adaptive immune response. Cytokines are essential effectors of both of these systems. In particular, type I interferons (IFN-I) are important components of early innate immunity against an infection. However, the production of IFN-I could serve as a double edge sword, either containing an infection or enhancing susceptibility. For example, IFN-I, which is essential for early containment of viral infections, has been shown to be detrimental to the host during bacterial infections. In fact, recent significant reports have shown that influenza virus induced IFN-I responses can enhance the host susceptibility to secondary bacterial infections. These recent reports highlight the expanding immunoregulatory role of IFN-I in the host immunity. With these recent findings in mind, the aim of this research topic is to welcome novel data, opinion and literature reviews on the newly identified dual functions of IFN-I. This research topic wills focus on the following areas of IFN-I: 1) a detrimental role of IFN-I during primary bacterial infection; 2) a detrimental role of viral infection induced IFN-I during secondary bacterial infections; 3) evolutionary pressure that drove detrimental IFN-I response during primary bacterial infection; and 4) does benefit of IFN-I responses during primary viral infections outweigh the adverse consequences of IFN-I mediated enhanced susceptibility to secondary bacterial infections.
    Keywords: R5-920 ; RC581-607 ; Autoimmunity ; adjuvant ; bacterial and viral infections ; Vaccine ; type I IFN ; bic Book Industry Communication::M Medicine
    Language: English
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  • 90
    Publication Date: 2024-03-29
    Description: In the ‘broad church’ of the Australian Liberal Party, rarely has there been a maverick so unrelenting in his commitment to personal principles as Senator Peter Baume. Over a parliamentary career spanning 17 years, three ministerial portfolios and five party leaders, Baume was increasingly pitted against his own party room. In A Dissident Liberal: The Political Writings of Peter Baume, we learn of personal threats, crises, constitutional confrontation and the tension between conservatism and classical liberalism—and between ideology and toeing the party line. This collection of personal observations, speeches and commentaries on contentious policy issues presents a valuable resource for students of Australian political history.
    Keywords: australia ; political history ; australian liberal party ; peter baume ; Australia ; Australian Senate ; Liberalism ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 91
    Publication Date: 2023-12-21
    Description: Plasticity is the hallmark of stem cells. At the same time, stem cells, like any other cell type, are influenced by their microenvironment and respond to it accordingly. A specific microenvironment is defined by a variety of factors, including biological and chemical factors, cell-cell interactions, but also metabolic and mechanical cues. Such dynamic and specialized microenvironment where the stem cells reside is considered a stem cell niche. Tissue injury as well as malignant tissue alterations lead to changes in the niche influencing the plasticity and biology of residing stem cells. Similarly, the niche changes upon tissue damage, which eventually induces differentiation of stem cells and ultimately regeneration of the tissue.
    Keywords: R5-920 ; QH301-705.5 ; RC581-607 ; Q1-390 ; microenvironment ; stem cells ; tissue regeneration ; immunomodulation ; extracellular vesicles (EVs) ; oxygen tension ; plasticity ; imaging ; bic Book Industry Communication::M Medicine
    Language: English
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  • 92
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    Springer Nature | Palgrave Macmillan
    Publication Date: 2024-03-29
    Description: This open access book outlines development theory and practice over time as well as critically interrogates the “cultural turn” in development policy in Latin American indigenous communities, specifically, in Guatemala, Honduras, Ecuador, and Bolivia. It becomes apparent that culturally sustainable development is both a new and old idea, which is simultaneously traditional and modern, and that it is a necessary iteration in thinking on development. This new strain of thought could inform not only the work of development practitioners, graduate students, and theorists working in the Global South, but in the Global North as well.
    Keywords: Latin American Politics ; Development and Sustainability ; Regional Development ; Development and Social Change ; Development Policy ; Latin America ; Sustainable Development ; NEOLIBERAL MULTICULTURALISM ; Development movements ; DEVELOPMENT THEORY ; Politics & government ; South & Central America (including Mexico), Latin America ; Sustainability ; Development studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::R Earth sciences, geography, environment, planning::RN The environment::RNU Sustainability ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; thema EDItEUR::J Society and Social Sciences::JP Politics and government ; thema EDItEUR::R Earth Sciences, Geography, Environment, Planning::RN The environment::RNU Sustainability ; thema EDItEUR::G Reference, Information and Interdisciplinary subjects::GT Interdisciplinary studies::GTP Development studies
    Language: English
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  • 93
    Publication Date: 2023-12-21
    Description: NETosis, a form of cell death that manifests by the release of decondensed chromatin to the extracellular space, provides valuable insights into mechanisms and consequences of cellular demise. Because extracellular chromatin can immobilize microbes, the extended nucleohistone network was called a neutrophil extracellular trap (NET), and the process of chromatin release was proposed to serve an innate immune defense function. Extracellular chromatin NETs were initially observed in studies of neutrophils and are most prominent in these types of granulocytes. Subsequent studies showed that other granulocytes and, in a limited way, other cells of the innate immune response may also release nuclear chromatin following certain kinds of stimulation. Variations of NETosis were noted with cells that remain temporarily motile after the release of chromatin. Numerous stimuli for NETosis were discovered, including bacterial breakdown products, inflammatory stimuli, particulate matter, certain crystals, immune complexes and activated thrombocytes. Fundamental explorations into the mechanisms of NETosis observed that neutrophil enzyme activity (PAD4, neutrophil elastase, proteinase 3 and myeloperoxidase) and signal transduction pathways contribute to the regulation of NETosis. Histones in NET chromatin become modified by peptidylarginine deiminase 4 (PAD4) and cleaved at specific sites by proteases, leading to extensive chromatin externalization. In addition, NETs serve for attachment of bactericidal enzymes including myeloperoxidase, leukocyte proteases, and the cathelicidin LL-37. NETs are decorated with proteases and may thus contribute to tissue destruction. However, the attachment of these enzymes to NET-associated supramolecular structures restricts systemic spread of the proteolytic activity. While the benefit of NETs in an infection appears obvious, NETs also participate as key protagonists in various pathologic states. Therefore, it is essential for NETs to be efficiently cleared; otherwise digestive enzymes may gain access to tissues where inflammation takes place. Persistent NET exposure at sites of inflammation may lead to a further complication: NET antigens may provoke acquired immune responses and, over time, could initiate autoimmune reactions, serve as antigen for nuclear autoantibodies and foster DNA immune complex-related inflammation. Neutrophil products and deiminated proteins comprise an important group of autoantigens in musculoskeletal disorders. Aberrant NET synthesis and/or clearance are often associated with inflammatory and autoimmune conditions. Recent evidence also implicates aberrant NET formation in the development of endothelial damage, atherosclerosis and thrombosis. Intravital microscopy provides evidence for conditions that induce NETosis in vivo. Furthermore, NETs can easily be detected in synovial fluid and tissue sections of patients with arthritis and gout. NETosis is thus of interest to researchers who investigate innate immune responses, host-pathogen interactions, chronic inflammatory disorders, cell and vascular biology, biochemistry, and autoimmunity. As we enter the second decade of research on NETosis, it is useful and timely to review the mechanisms and pathways of NET formation, their role in bacterial and fungal defense and their importance as inducers of autoimmune responses.
    Keywords: R5-920 ; RC581-607 ; Infection ; Autoimmunity ; Microscopy ; Immune Cell Interactions ; Neutrophil Extracellular Traps ; Inflammation ; Mechanisms of Cell Death ; Chronic Disease ; bic Book Industry Communication::M Medicine
    Language: English
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  • 94
    Publication Date: 2023-12-21
    Description: Early studies recognized the unique phenotype and attributes of T cells found in mucosal tissues, such as the intestines, skin, lung and female reproductive tract. This special topic issue will cover many aspects of mucosal-resident T cell biology during infection and disease and is dedicated to Leo Lefrancois, a pioneer in this field who recently passed away. A major proportion of these mucosal T cells are memory T cells, now recognized as a major constituent of memory T cells referred to as tissue-resident memory T cells. Unlike central and effector memory T cell subsets, tissue-resident memory T cells exhibit tissue specificity with minimal systemic migration. Nonetheless, tissue-resident memory T cells share a similar origin and display some overlapping phenotypes with their other memory T cell counterparts. Articles in this issue will describe the different types of memory T cells residing in mucosal tissues, their origins and functions as well as how they vary among discrete mucosal sites. Manuscripts will consider the unique physiological environments and cellular constituents which facilitate tissue residency while preserving tissue function. Additionally, there will be descriptions of the various mechanisms responsible for the migration and segregation of tissue resident memory CD8 T cells from the peripheral T cell pool. Although the mechanisms facilitating the sequestration of tissue-resident memory T cells within a respective tissue has not well characterized, various theories will also be discussed. Lastly, how these T cells contribute to immunity to pathogens, cancer, and autoimmunity and could be modified through vaccination or therapeutic intervention will be described. As mucosal tissues are the major portals of pathogen entry and frequent transformation, the activities and persistence of tissue resident memory T cells is crucial for mediating protection at these sites.
    Keywords: R5-920 ; RC581-607 ; pathogens ; Microscopy ; Migration ; Mucosa ; T cell differentiation ; Vaccination ; Inflammation ; Epithelium ; CD103 ; bic Book Industry Communication::M Medicine
    Language: English
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  • 95
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    Unknown
    Frontiers Media SA
    Publication Date: 2023-12-21
    Description: Trypanosoma cruzi is a pathogenic protozoan of the Trypanosomatidade Family, which is the etiological agent of Chagas’ disease. Chagas’ disease stands out for being endemic among countries in Latin America, affecting about 15 million people. Recently, Chagas has become remarkable in European countries as well due to cases of transmission via infected blood transfusion. An important factor that has exacerbated the epidemiological picture in Brazil, Colombia and Venezuela is infection after the oral intake of contaminated foods such as sugar cane, açai and bacaba juices. Trypanosoma cruzi is an intracellular protozoan that exhibits a complex life cycle, involving multiple developmental stages found in both vertebrate and invertebrate hosts. In vertebrate hosts, the trypomastigote form invades a large variety of nucleated cells using multiple mechanisms. The invasion process involves several steps: (a) attraction of the protozoan to interact with the host cell surface; (b) parasite-host cell recognition; (c) adhesion of the parasite to the host cell surface; (d) cell signalling events that culminate in the internalization of the parasite through endocytic processes; (e) biogenesis of a large vacuole where the parasite is initially located, and is also known as parasitophorous vacuole (PV); (f) participation of endocytic pathway components in the internalization process; (g) participation of cytoskeleton components in the internalization process; (h) transformation of the trypomastigote into the amastigote form within the PV; (i) lysis of the membrane of the PV; (j) multiplication of amastigotes within the host cell in direct contact with cell structures and organelles; (k) transformation of amastigotes into trypomastigotes, and (l) rupture of the host cell releasing trypomastigotes into the extracellular space. The kinetics of the interaction process and even the fate of the parasite within the cell vary according to the nature of the host cell and its state of immunological activation.
    Keywords: R5-920 ; RC581-607 ; QR1-502 ; Q1-390 ; Chagas Disease ; Parasite-host cell interaction ; cell-to-cell recognition ; Parasitic protozoa ; Trypanosoma cruzi ; bic Book Industry Communication::M Medicine
    Language: English
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  • 96
    Publication Date: 2021-02-10
    Description: ‘The Maternal Sepsis Intervention has had a profound impact on maternal mortality and antibiotic use whilst also reducing hospital costs. The Ministry of Health is keen to explore opportunities to extending the lessons learnt and integrate them in national policy-making.' -Dr. Richard Mugahi, Ministry of Health, Uganda. This open access book provides an accessible introduction to the mechanics of international development and global health text for policy-makers and students across a wide range of disciplines. Antimicrobial resistance is a major threat to the well-being of patients and health systems the world over. In fragile health systems so challenged, on a day-today basis, by the overwhelming burden of both infectious and non-communicable disease, it is easy to overlook the impacts of AMR. The Maternal Sepsis Intervention, focusing on a primary cause of maternal death in Uganda, demonstrates the systemic nature of AMR and the gains that can be made through improved Infection Prevention Control and direct engagement of laboratory testing in antibiotic prescribing.
    Keywords: Development and Health ; Public Policy ; African Politics ; Public Health ; Globalization ; Development Studies ; AMR ; global health ; Uganda ; antibiotics ; Infection Prevention Control ; health worker behavior ; midwives ; Global Point Prevalence Survey ; public health facilities ; public health policy ; Open Access ; Public administration ; Politics & government ; Africa ; Public health & preventive medicine ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GT Interdisciplinary studies::GTF Development studies ; bic Book Industry Communication::J Society & social sciences::JP Politics & government::JPP Public administration ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; bic Book Industry Communication::M Medicine::MB Medicine: general issues::MBN Public health & preventive medicine ; bic Book Industry Communication::J Society & social sciences::JF Society & culture: general::JFF Social issues & processes::JFFS Globalization
    Language: English
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  • 97
    Publication Date: 2024-03-13
    Description: Indonesia suffered an explosion of religious violence, ethnic violence, separatist violence, terrorism, and violence by criminal gangs, the security forces and militias in the late 1990s and early 2000s. By 2002 Indonesia had the worst terrorism problem of any nation. All these forms of violence have now fallen dramatically. How was this accomplished? What drove the rise and the fall of violence? Anomie theory is deployed to explain these developments. Sudden institutional change at the time of the Asian financial crisis and the fall of President Suharto meant the rules of the game were up for grabs. Valerie Braithwaite’s motivational postures theory is used to explain the gaming of the rules and the disengagement from authority that occurred in that era. Ultimately resistance to Suharto laid a foundation for commitment to a revised, more democratic, institutional order. The peacebuilding that occurred was not based on the high-integrity truth-seeking and reconciliation that was the normative preference of these authors. Rather it was based on non-truth, sometimes lies, and yet substantial reconciliation. This poses a challenge to restorative justice theories of peacebuilding.
    Keywords: politics and government ; conflictmanagement ; social conditions ; social conflict ; indonesia ; political violence ; Aceh ; Dayak people ; Indigenous people of New Guinea ; Madurese people ; Maluku Islands ; Papua (province) ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 98
    Publication Date: 2022-04-28
    Description: May 19, 2000. Fiji’s democratically elected multiracial government is hijacked by a group of armed gunmen led by George Speight, and held hostage for fifty days. Suva, the capital, is torched and looted as Speight’s supporters gather on the lawns of the parliamentary complex, dancing, cooking food, celebrating the purported abrogation of the constitution that brought the People’s Coalition government to power. The country is plunged into darkness yet again, enduring the pain of three coups in a period of just thirteen years. The process of healing and reconciliation, symbolised by the enactment of a new Constitution, unanimously approved by Parliament and blessed by the powerful Great Council of Chiefs, lies discarded, as winds of ethnic chauvinism sweep through the countryside, damaging the fragile fabric of multiculturalism that was carefully constructed by so many over many years. The economy is on the brink of collapse, investor confidence has vanished, and the best and the brightest are seeking succour on other shores. Fiji falls victim, yet again, to the prejudice and greed of a section of its people. This book gathers together a handful of memoirs of those tragic events in Fiji. They were written while the gun was still smoking; personal, anguished reactions of people from all walks of life, concerned about a country they all love but deeply distressed by the developments there. They are first reactions. They will in time become essential building blocks for a larger interpretive framework of academic analysis about origins, processes and impacts. Straight from the heart, these memoirs will be remembered as the people of Fiji and their friends elsewhere contemplate the wreckage and ruin brought about by that act of madness in the month of May 2000.
    Keywords: politics and goverment ; fiji ; 2000 Fijian coup d'état ; Fijians ; George Speight ; Indo-Fijians ; Mahendra Chaudhry ; Sitiveni Rabuka ; bic Book Industry Communication::J Society & social sciences::JP Politics & government
    Language: English
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  • 99
    Publication Date: 2024-03-29
    Description: This book explores the factors behind – and the implications of – the 2006 coup. It brings together contributions from leading scholars, local personalities, civil society activists, union leaders, journalists, lawyers, soldiers and politicians – including deposed Prime Ministers Laisenia Qarase and Mahendra Chaudhry. The 2006 Military Takeover in Fiji: A Coup to End All Coups? is essential reading for those with an interest in the contemporary history of Fiji, politics in deeply divided societies, or in military intervention in civilian politics.
    Keywords: politics and government ; government ; history ; 21th century ; fiji ; Democracy ; Fijians ; Frank Bainimarama ; Laisenia Qarase ; Mahendra Chaudhry ; Republic of Fiji Military Forces ; bic Book Industry Communication::J Society & social sciences::JP Politics & government ; thema EDItEUR::J Society and Social Sciences::JP Politics and government
    Language: English
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  • 100
    Publication Date: 2023-12-21
    Description: Over the last years it has become evident that many neurological diseases of the central nervous system (CNS) are induced by a specific adaptive immune response directed against molecules expressed on CNS-resident cells. Well-recognized examples are anti-N-Methyl-D-Aspartate Receptor (NMDAR) encephalitis which is characterized by the presence of antibodies against neuron-expressed NMDAR, or neuromyelitis optica (NMO), induced by antibodies to astrocyte-expressed aquaporin-4. Many more examples exist, and antibodies, and T or/and B cells have increasingly been associated with CNS disease. Often the symptoms of these diseases have not been typically reported to have an immune aetiology. Beside classical neurological symptoms like ataxia, vision disturbance, and motor or sensory symptoms, these can include cognitive disturbances, behavioral abnormalities, or/and epileptic seizures. Although much has been learned regarding the pathophysiology of prototypic examples of these disorders, there are still major gaps in our understanding of their biology. This may be due to the fact that they are rare diseases, and their therapies are still very limited. This research topic includes contributions addressing the analysis of the adaptive immune response driving disease including target antigens, molecular epitope mapping, and factors involved in the disease pathogenesis such as complement activation cascades, genetic and genomic regulation, as well as environmental triggers. Diagnostic criteria and methods, and treatment are also discussed. The overall aim of the volume is to review progress in our pathophysiological understanding of immune-mediated CNS disorders in order to advance diagnostic and therapeutic approaches, and ultimately improve outcomes for patients.
    Keywords: R5-920 ; RC346-429 ; RC581-607 ; autoimmune encephalitis ; autophagy ; aquaporin-4 ; multiple sclerosis ; neuromyelitis optica spectrum disorder ; T cell ; thyroid gland ; B cells ; NMDA receptor ; myelin oligodendrocyte glycoprotein ; bic Book Industry Communication::M Medicine
    Language: English
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