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  • History
  • bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
  • Archaeopress Publishing Ltd  (28)
  • Frontiers Media SA  (27)
  • English  (53)
  • Spanish  (2)
  • Latin
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  • English  (53)
  • Spanish  (2)
  • Latin
  • Arabic  (1)
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  • 11
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    Function and Flexibility: Friend or Foe? (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-20
    Description: Louis Sullivan (1856 - 1924) revolutionized architecture by designing the first skyscraper and he became famous by proclaiming that “form follows function”. When x-ray crystallographers visualized the structures of proteins for the first time, the structural biology field embraced the view that “function follows form” as the 3D-architecture of proteins could unveil various aspects of their function. Despite the original “1 gene - 1 protein structure - 1 function” relationship, nowadays a far more complicated picture emerges where the flexibility and dynamics of a protein can play a central role in a multitude of functions. The ultimate form(s) that a protein adopt when interacting with (a) partner molecule(s) are the most biologically relevant and in this context Sullivan’s quote is still appropriate: the conformation that the protein adopts follows from the function of that protein. Despite the fact that many well-characterized proteins have a well-folded structure, there is a growing interest in the conformational flexibility within proteins. This flexibility is also a balanced phenomenon: excess of flexibility can be detrimental for protein behaviour, as well as the lack thereof. Notwithstanding its importance, studying intrinsically disordered protein regions or conformational rearrangements can be a very challenging. Therefore, flexibility can be perceived as a friend or a foe, depending on the context. This e-book showcases the impact of the study of protein flexibility on the structural biology field and presents protein flexibility in the context of disease as well as its benign aspects. As detailed knowledge of the structural aspects of polypeptides remains essential to comprehend protein function, one of the future challenges for structural biology also lies with large macromolecular protein complexes. Also there the dynamics and flexibility are essential for proper functioning and molecular movement, which is an important aspect of living matter. This challenge stimulated the development of advanced techniques to study protein flexibility and the use of those techniques to address fundamental biological and biomedical problems. Those innovations should help us to unravel the intimate link between protein function and flexibility and explore new horizons.
    Keywords: Q1-390 ; conformational selection and induced fit ; protein structure ; conformational ensemble ; Protein function ; protein dynamics ; Protein Conformation ; protein flexibility ; Protein Disorder ; intrinsically disordered proteins ; Structural transition ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 12
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    The Roman Lower Danube Frontier (2023)
    Archaeopress Publishing Ltd
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    Publication Date: 2024-04-02
    Description: Over the past few decades, there has been a significant amount of research on the Roman Lower Danube frontier by international teams focusing on individual forts or broader landscape survey work; collectively, this volume represents the best of this collaboration with the aim of elevating the Lower Danube within broader Roman frontier scholarship.The Lower Danube, running between Singidunum (modern Belgrade) and Halmyris in the Danube Delta, was one of the most densely fortified regions of the Roman Empire. The region has long been a border zone, today forming part of the border between Serbia and Romania, and the majority of the border between Romania and Bulgaria. Despite its importance for understanding both Roman frontier policy and the relationship between ancient and modern borderscapes, the region has not yet made its full contribution to international Roman scholarship. Bridging the theoretical divide that exists between different regional research traditions, chapters in this volume focus on sites like Ratiaria, in modern north-western Bulgaria, while other contributors examine the complex landscape from a wider perspective oriented around roads, temporary camps, or early Christian sites. The Roman Lower Danube Frontier emphasises the importance of engaging with Roman frontier landscapes, particularly in regions such as East-Central Europe, where they remain part of a contemporary borderscape.
    Keywords: History ; Ancient ; Rome ; Social Science ; Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history ; thema EDItEUR::N History and Archaeology::NK Archaeology
    Language: English
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  • 13
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    The Roman Cemetery at Lankhills (2022)
    Archaeopress Publishing | Archaeopress Publishing Ltd
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    Publication Date: 2024-04-02
    Description: Outside the north gate of Venta Belgarum, Roman Winchester, a great cemetary stretched for 500 yards along the road to Cirencester. Excavations at Lankhills from 1967 to 1972 uncovered 451 graves, many elaborately furnished, at the northern limits of this cemetery, and dating from the fourth century A.D. This book, the second in a two-part study of Venta Belgarum, which forms the third volume of Winchester Studies, describes the excavations of these burials and analyses in detail both the graves and their contents. There are detailed studies and important re-assessments of many categories of object, but it is the information about late Roman burial, religion, and society which is of special interest.
    Keywords: History ; Ancient ; Rome ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 14
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    Obsidian Across the Americas (2023)
    Archaeopress Publishing Ltd
    Details
    Publication Date: 2024-04-02
    Description: Obsidian Across the Americas draws attention to recent obsidian studies in the Americas and acts as a reference for archaeologists and scholars interested in material culture and exchange. Moreover, it provides a wide range of case studies in obsidian characterization, material application, and theoretical interpretations in the Americas. The limited geographic occurrence and relatively homogenous nature of obsidian have made the material ideal for archaeometric studies. Since Cann and Renfrew’s seminal paper in 1967 on the compositional analysis of obsidian in the Mediterranean, analytical techniques have improved, identification and characterization of sources have increased, and applications have broadened geographically and theoretically to address various socio-cultural activities and behaviours around the world. While many previous publications have focused on different aspects of obsidian characterization, this volume uniquely presents obsidian compositional studies from across the Americas that have relied on the instrumentation housed in the Elemental Analysis Facility at the Field Museum of Natural History. The case studies, which feature materials from North American, Mesoamerican, and South American geological sources, explore the ways in which obsidian analyses have been used to investigate interactions, socio-economic exchanges, and socio-cultural change at multiple scales in the past.
    Keywords: History ; North America ; History ; Latin America ; Pre-columbian Era ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: English
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  • 15
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    Stratton, Biggleswade (2022)
    Archaeopress Publishing | Archaeopress Publishing Ltd
    Details
    Publication Date: 2024-04-04
    Description: Stratton, Biggleswade: 1,300 years of village life in eastern Bedfordshire from the 5th century AD presents the results of 12 hectares of archaeological excavation undertaken between 1990 and 2001. As well as uncovering roughly half of the medieval village, the investigations revealed that Stratton’s origins stretched back to the early Anglo-Saxon period, with the settlement remaining in continuous use through to c. 1700. In contrast to many of the other major excavations of Anglo-Saxon settlements, the evidence from Stratton provides insights into the lives of a low-status rural community, whose development can be traced over the course of more than a millennium. This book presents a chronological account of Stratton’s development; evidence for its economy, trading relations, industrial activities and agricultural landscape; and a discussion of how people lived and died there before the village was finally extinguished by the creation of the classic estate landscape of Stratton Park.
    Keywords: Social Science ; Archaeology ; History ; Europe ; Great Britain ; Middle Ages (449-1066) ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHD European history
    Language: English
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  • 16
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    1982 Uncovered (2023)
    Archaeopress Publishing Ltd
    Details
    Publication Date: 2024-04-04
    Description: War and its legacy are traumatic to individuals, communities, and landscapes. The impacts last long beyond the events themselves and shape lives and generations. Archaeology has a part to play in the recording of, and recovery from, such trauma. The Falklands War Mapping Project delivers the first intensive archaeological survey of the battlefields of the Falklands War. The project is pioneering in its inclusion of military veterans as part of the core team and unique in being the first to take veterans back to the battlefields on which they fought. Forty years after the events of 1982, the project provides a detailed assessment of the character, location, and condition of structural features and artefacts. The project also develops understandings of the role played by conflict heritage – and of landscapes, finds, and past events – in the recall of personal and collective memories. This sumptuously illustrated book brings together the perspectives of team members, institutional partners and others. It showcases the varied and important contributions archaeology can make beyond understandings of distant events linked to therapeutic progress, coming to terms with traumatic experiences, living with the past in the present, and forging new memories, relations, and futures.
    Keywords: Social Science ; Archaeology ; History ; Military ; Wars & Conflicts (other) ; Medical ; Allied Health Services ; Occupational Therapy ; thema EDItEUR::N History and Archaeology::NK Archaeology ; thema EDItEUR::N History and Archaeology::NH History::NHW Military history ; thema EDItEUR::M Medicine and Nursing::MQ Nursing and ancillary services::MQT Occupational therapy
    Language: English
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  • 17
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    Contextualización del reconocimiento arqueológico de Eduard Seler en la Región de Chaculá, Departamento de Huehuetenango, Guatemala (2022)
    Archaeopress Publishing | Archaeopress Publishing Ltd
    Details
    Publication Date: 2024-04-02
    Description: This study re-examines and contextualises Eduard Seler's investigations in the Chaculá-Region (Department of Huehuetenango, Guatemala). Starting with a discussion of ethnohistory as well as the historical circumstances of Seler's research, his methods are critically examined in the context of archaeology in late 19th century Guatemala and the practice of collecting by European museums, specifically the Ethnological Museum Berlin. This is followed by the results of a reconnaissance of the different archaeological sites documented by Seler in the region, in which their current state of preservation is examined and Seler's excavation trenches are re-discovered. The core of the work is a new study of the materials from the region in the collection of the Ethnological Museum Berlin, including previously undocumented ceramic materials. Through typological cross-dating, a first ceramic chronology for the region is established, showing that the major settlements were occupied from the Late Classic (600-900) to the Early Postclassic (900-1250). These data and observations form the foundation for a re-examination of the interpretations put forth by Eduard Seler and later scholars, concerning topics such as architecture, burials and caches, the function of the Quen Santo caves, ritual and settlement continuity from the Late Classic to modern times and the ethnolinguistic identity of the ancient inhabitants of the region. The book concludes with a look at the postcolonial challenges that the collection in Berlin faces and ways to connect the archaeological past with the indigenous present in the Chaculá-Region.
    Keywords: History ; Latin America ; Pre-columbian Era ; thema EDItEUR::N History and Archaeology::NH History::NHK History of the Americas
    Language: Spanish
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  • 18
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    The Role of Iron in Bacterial Pathogenesis (2021)
    Frontiers Media SA
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    Publication Date: 2023-12-20
    Description: The collection of articles published in this eBook represent different facets of the interactions between pathogens and their host concerning the battle for iron. Pathogens have developed different strategies to acquire iron from their host. These include the production of siderophores, heme acquisition and ferrous iron uptake.
    Keywords: Q1-390 ; RC109-216 ; Infection ; nutritional immunity ; Virulence ; Bacterial Pathogenesis ; bacterioferritin ; iron acquisition ; siderophore ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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  • 19
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    The pathogenic Yersiniae - advances in the understanding of physiology and virulence (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-20
    Description: For decades, pathogenic Yersinia have served as an inventive model organism for researchers seeking to understand the complexities of bacteria-host cell interactions. In fact, seminal studies on Yersinia virulence mechanisms contributed to the emergence and recognition of the research field - cellular microbiology. Researching Yersinia infection biology continues to identify and define fascinating virulence and survival mechanisms that advance and expand existing perceptions of bacterial-host encounters. This also includes research that defines how the pathogenic Yersiniae respond to diverse physicochemical stimuli to spatially and temporally control this armory of customized virulence and survival factors. Yet additional research demonstrates how the application of powerful whole genomic-based methodologies can open new frontiers that further facilitate understanding of bacterial evolution and pathogenicity. This Research Topic is therefore focused on presenting and summarizing new developments in Yersinia patho-physiology through highlighting cutting- edge studies on the Yersinia-host cell interaction and the network of regulatory control mechanisms that define this outcome.
    Keywords: Q1-390 ; RC109-216 ; stress ; pathogenicity ; secretion ; regulation ; immune response ; Yersinia ; Virulence ; evolution ; Survival ; Adhesion ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
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  • 20
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    Shiga toxin-producing Escherichia coli in human, cattle and foods. Strategies for detection and control (2021)
    Frontiers Media SA
    Details
    Publication Date: 2023-12-20
    Description: Shiga toxin-producing Escherichia coli (STEC) is an important foodborne pathogen associated with both outbreaks and sporadic cases of human disease, ranging from uncomplicated diarrhoea to haemorrhagic colitis (HC) and haemolytic uraemic syndrome (HUS). STEC affects children, elderly and immuno-compromised patients. STEC is capable of producing Shiga toxin type 1 (Stx1), type 2 (Stx2) or both, encoded by stx1 and stx2 genes, respectively. These strains are likely to produce putative accessory virulence factors such as intimin (encoded by eae), an enterohaemolysin (EhxA) and an autoagglutinating protein commonly associated with eae-negative strains (Saa), both encoded by an enterohaemorrhagic plasmid. Several studies have confirmed that cattle are the principal reservoir of STEC (O157 and non-O157:H7 serotypes) and many of these serotypes have been involved in HUS and HC outbreaks in other countries. Transmission of STEC to humans occurs through the consumption of undercooked meat, vegetables and water contaminated by faeces of carriers and by person-to-person contact. Diagnostic methods have evolved to avoid selective diagnostics, currently using molecular techniques for typing and subtyping of strains. Control is still a challenge, although there are animal vaccines directed against the serotype O157:H7.
    Keywords: Q1-390 ; RC109-216 ; environment ; Cattle ; STEC ; Virulence Factors ; Food ; bic Book Industry Communication::G Reference, information & interdisciplinary subjects::GP Research & information: general
    Language: English
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